CDV3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.11983696
2nuclear pore organization (GO:0006999)4.97107104
3membrane raft organization (GO:0031579)4.43523062
4protein localization to kinetochore (GO:0034501)4.38184437
5DNA replication initiation (GO:0006270)4.33345305
6DNA unwinding involved in DNA replication (GO:0006268)4.26121146
7mitotic metaphase plate congression (GO:0007080)4.17379255
8IMP biosynthetic process (GO:0006188)4.17247610
9mitotic nuclear envelope disassembly (GO:0007077)4.09291818
10DNA strand elongation involved in DNA replication (GO:0006271)4.04250799
11pore complex assembly (GO:0046931)3.96253718
12nucleobase biosynthetic process (GO:0046112)3.94639888
13DNA replication-dependent nucleosome assembly (GO:0006335)3.91488601
14DNA replication-dependent nucleosome organization (GO:0034723)3.91488601
15DNA strand elongation (GO:0022616)3.84933749
16membrane disassembly (GO:0030397)3.80491865
17nuclear envelope disassembly (GO:0051081)3.80491865
18telomere maintenance via semi-conservative replication (GO:0032201)3.80153454
19IMP metabolic process (GO:0046040)3.78635189
20DNA replication checkpoint (GO:0000076)3.77715061
21protein localization to chromosome, centromeric region (GO:0071459)3.77153094
22folic acid-containing compound biosynthetic process (GO:0009396)3.73574398
23ribosome assembly (GO:0042255)3.67909121
24mitotic chromosome condensation (GO:0007076)3.67574402
25metaphase plate congression (GO:0051310)3.64949594
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.54879516
27chromatin remodeling at centromere (GO:0031055)3.54272477
28CENP-A containing nucleosome assembly (GO:0034080)3.53439398
29kinetochore organization (GO:0051383)3.53382314
30purine nucleobase biosynthetic process (GO:0009113)3.49926906
31telomere maintenance via recombination (GO:0000722)3.49428729
32maturation of SSU-rRNA (GO:0030490)3.47991283
33mitotic recombination (GO:0006312)3.45713937
34formation of translation preinitiation complex (GO:0001731)3.42416492
35ribosome biogenesis (GO:0042254)3.41507177
36regulation of spindle organization (GO:0090224)3.37868112
37DNA replication-independent nucleosome organization (GO:0034724)3.32832368
38DNA replication-independent nucleosome assembly (GO:0006336)3.32832368
39protein K6-linked ubiquitination (GO:0085020)3.30366262
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29648113
41mitotic sister chromatid segregation (GO:0000070)3.27402884
42DNA duplex unwinding (GO:0032508)3.25114882
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24944393
44DNA geometric change (GO:0032392)3.23794927
45regulation of histone H3-K9 methylation (GO:0051570)3.23748634
46mitotic sister chromatid cohesion (GO:0007064)3.22765468
47sister chromatid segregation (GO:0000819)3.22192927
48negative regulation of DNA repair (GO:0045738)3.19347682
49ribosomal small subunit assembly (GO:0000028)3.18435989
50histone exchange (GO:0043486)3.18370039
51hepatocyte apoptotic process (GO:0097284)3.17859372
52establishment of chromosome localization (GO:0051303)3.17379773
53positive regulation of chromosome segregation (GO:0051984)3.14111962
54telomere maintenance via telomere lengthening (GO:0010833)3.12688742
55meiotic chromosome segregation (GO:0045132)3.09674462
56regulation of posttranscriptional gene silencing (GO:0060147)3.07480173
57regulation of gene silencing by miRNA (GO:0060964)3.07480173
58regulation of gene silencing by RNA (GO:0060966)3.07480173
59ribonucleoprotein complex biogenesis (GO:0022613)3.06350866
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.01908132
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01908132
62chromatin assembly or disassembly (GO:0006333)3.01880206
63attachment of spindle microtubules to kinetochore (GO:0008608)2.97264876
64kinetochore assembly (GO:0051382)2.97143794
65nucleotide-excision repair, DNA gap filling (GO:0006297)2.96169454
66COPII vesicle coating (GO:0048208)2.95844331
67nuclear envelope organization (GO:0006998)2.95401130
68histone H2A monoubiquitination (GO:0035518)2.93974081
69ribosomal large subunit biogenesis (GO:0042273)2.92787782
70chromatin assembly (GO:0031497)2.92160943
71Golgi transport vesicle coating (GO:0048200)2.91855626
72COPI coating of Golgi vesicle (GO:0048205)2.91855626
73necroptotic process (GO:0070266)2.89917011
74spindle checkpoint (GO:0031577)2.89524847
75protein localization to chromosome (GO:0034502)2.88585774
76protein localization to endosome (GO:0036010)2.87857462
77regulation of centrosome cycle (GO:0046605)2.87346965
78ATP-dependent chromatin remodeling (GO:0043044)2.87005632
79regulation of mitotic spindle organization (GO:0060236)2.86385464
80regulation of double-strand break repair via homologous recombination (GO:0010569)2.83664994
81DNA conformation change (GO:0071103)2.82074246
82monoubiquitinated protein deubiquitination (GO:0035520)2.81637313
83regulation of histone H3-K27 methylation (GO:0061085)2.80325891
84negative regulation of histone methylation (GO:0031061)2.79673786
85regulation of chromosome segregation (GO:0051983)2.77740912
86regulation of RNA export from nucleus (GO:0046831)2.77738617
87regulation of helicase activity (GO:0051095)2.76795276
88regulation of translational termination (GO:0006449)2.75594855
89heterochromatin organization (GO:0070828)2.75199802
90rRNA processing (GO:0006364)2.74984096
91pinocytosis (GO:0006907)2.72899013
92dosage compensation (GO:0007549)2.72775715
93chromosome segregation (GO:0007059)2.70211461
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69286019
95mitotic spindle checkpoint (GO:0071174)2.69163808
96rRNA metabolic process (GO:0016072)2.68933031
97regulation of sister chromatid cohesion (GO:0007063)2.68769734
98negative regulation of chromosome segregation (GO:0051985)2.68187746
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66974083
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66974083
101positive regulation of mitotic sister chromatid separation (GO:1901970)2.66974083
102translational initiation (GO:0006413)2.66959773
103translesion synthesis (GO:0019985)2.66095198
104mRNA transport (GO:0051028)2.65651770
105regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.65463116
106maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64407819
107chromosome condensation (GO:0030261)2.63753447
108negative regulation of mitotic sister chromatid separation (GO:2000816)2.62361585
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62361585
110negative regulation of sister chromatid segregation (GO:0033046)2.62361585
111activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.53891509
112negative regulation of fibroblast apoptotic process (GO:2000270)2.48164588
113B cell proliferation (GO:0042100)2.48061649
114negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.46106818
115ER overload response (GO:0006983)2.40549878
116intestinal epithelial cell development (GO:0060576)2.39918020
117regulation of vitamin D biosynthetic process (GO:0060556)2.39330733
118regulation of fibroblast apoptotic process (GO:2000269)2.39052305
119hippo signaling (GO:0035329)2.38145885
120positive regulation of interferon-alpha production (GO:0032727)2.37078672
121NLS-bearing protein import into nucleus (GO:0006607)2.33298414
122NIK/NF-kappaB signaling (GO:0038061)2.32171372
123regulation of transforming growth factor beta2 production (GO:0032909)2.31679362
124regulation of centriole replication (GO:0046599)2.27654096
125regulation of interferon-alpha production (GO:0032647)2.27162251
126positive regulation of keratinocyte differentiation (GO:0045618)2.26864471
127negative regulation of B cell proliferation (GO:0030889)2.24189667
128B cell homeostasis (GO:0001782)2.23675297
129cellular protein complex localization (GO:0034629)2.23279823
130Rap protein signal transduction (GO:0032486)2.22171643
131mRNA modification (GO:0016556)2.21727479
132negative regulation of protein localization to plasma membrane (GO:1903077)2.19342247
133positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.18630444
134iron ion import (GO:0097286)2.18333329
135germinal center formation (GO:0002467)2.16883890
136muscle cell cellular homeostasis (GO:0046716)2.16722775
137UDP-N-acetylglucosamine metabolic process (GO:0006047)2.15427403
138regulation of response to interferon-gamma (GO:0060330)2.14751125
139cellular response to interferon-alpha (GO:0035457)2.14215135
140protein export from nucleus (GO:0006611)2.14036523
141regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.13759359
142regulation of translation in response to stress (GO:0043555)2.10432958
143regulation of nucleobase-containing compound transport (GO:0032239)2.10125653
144cell adhesion mediated by integrin (GO:0033627)2.09902395
145CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.09352824
146regulation of translational initiation (GO:0006446)2.07076400
147positive regulation of protein oligomerization (GO:0032461)2.06952074
148heart contraction (GO:0060047)2.06897870
149heart process (GO:0003015)2.06897870
150trophoblast giant cell differentiation (GO:0060707)2.06655755
151non-recombinational repair (GO:0000726)2.05937758
152double-strand break repair via nonhomologous end joining (GO:0006303)2.05937758
153regulation of type I interferon-mediated signaling pathway (GO:0060338)2.04219182
154regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.03563965
155programmed necrotic cell death (GO:0097300)2.02635430
156positive regulation of myotube differentiation (GO:0010831)2.02439370
157nucleotide-sugar biosynthetic process (GO:0009226)2.02081124
158plasma membrane repair (GO:0001778)1.99595373
159negative regulation of anoikis (GO:2000811)1.99457772
160regulation of interferon-beta biosynthetic process (GO:0045357)1.98139655
161regulation of glucose import in response to insulin stimulus (GO:2001273)1.98123596
162nucleobase-containing small molecule interconversion (GO:0015949)1.97901624
163negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)1.97775799
164positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.97049685
165response to peptidoglycan (GO:0032494)1.94318359
166somatic recombination of immunoglobulin gene segments (GO:0016447)1.94046228
167negative regulation of potassium ion transmembrane transport (GO:1901380)1.92836540
168positive regulation of glycoprotein metabolic process (GO:1903020)1.92798861
169endoplasmic reticulum unfolded protein response (GO:0030968)1.92737066
170striated muscle atrophy (GO:0014891)1.92690895
171ER-nucleus signaling pathway (GO:0006984)1.92672692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.97991560
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.67974717
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08560469
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.07442024
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58603078
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.42426692
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96923903
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84905994
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72906129
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.65353327
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54535027
12AR_21909140_ChIP-Seq_LNCAP_Human2.53077665
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.41232293
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41216459
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39155335
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36379011
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34246572
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.32376567
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.27097519
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.23430278
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22275374
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20152626
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14989700
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05582877
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.05205324
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01936459
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.01828489
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01265572
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99509553
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96235069
31XRN2_22483619_ChIP-Seq_HELA_Human1.95761591
32CLOCK_20551151_ChIP-Seq_293T_Human1.85970564
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.85594390
34* VDR_23849224_ChIP-Seq_CD4+_Human1.84392428
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81054593
36MYC_22102868_ChIP-Seq_BL_Human1.79789878
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78140590
38GATA1_22025678_ChIP-Seq_K562_Human1.72835952
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71527126
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69917497
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68621888
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68593327
43ELK1_19687146_ChIP-ChIP_HELA_Human1.67286951
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66214545
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63135707
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63074939
47* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62214068
48* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62214068
49FOXP3_21729870_ChIP-Seq_TREG_Human1.61575930
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.57309964
51TTF2_22483619_ChIP-Seq_HELA_Human1.56429599
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55953460
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55287170
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54364110
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.52548125
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.52471635
57DCP1A_22483619_ChIP-Seq_HELA_Human1.52428318
58* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.51576132
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48917506
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48873986
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46826076
62BRD4_25478319_ChIP-Seq_HGPS_Human1.46433103
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46111297
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.45596001
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45373344
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44161930
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43810042
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.42440760
69KDM5A_27292631_Chip-Seq_BREAST_Human1.42339018
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41299161
71GABP_19822575_ChIP-Seq_HepG2_Human1.40883038
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38744475
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38463447
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.38173068
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37995316
76* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37798439
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37302186
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34736504
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33693579
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32893650
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32772274
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32528840
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30574127
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30230880
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29706549
86CIITA_25753668_ChIP-Seq_RAJI_Human1.29129748
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28172191
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24885986
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23909122
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22696034
91MYB_26560356_Chip-Seq_TH1_Human1.22031079
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21269207
93MYB_26560356_Chip-Seq_TH2_Human1.21000697
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16273269
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16091569
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15826309
97ELF5_23300383_ChIP-Seq_T47D_Human1.15249389
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15060604
99* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14761630
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12082798
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11797512
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09098376
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08854468
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.08229336
105FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07467729
106* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06969739
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06575288
108* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06413950
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06140332
110TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06030848
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05963905
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.05664310
113GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05378362
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04675791
115TP63_17297297_ChIP-ChIP_HaCaT_Human1.03914215
116NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03607222
117PU_27001747_Chip-Seq_BMDM_Mouse1.02500997
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01947595
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01251792
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00092164
121* ATF3_27146783_Chip-Seq_COLON_Human0.99547236
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99208804
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98949188
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98416963
125* TFEB_21752829_ChIP-Seq_HELA_Human0.97942020
126MYC_18940864_ChIP-ChIP_HL60_Human0.97024246
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96511741
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.96178586
129STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95610225
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.94618753
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94041087
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93142207
133KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93142207
134KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93142207
135TCF7_22412390_ChIP-Seq_EML_Mouse0.92383981
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90300624
137TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90158309
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89441633
139* UBF1/2_26484160_Chip-Seq_HMECs_Human0.89399746
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89143150
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87495722
142GATA6_25053715_ChIP-Seq_YYC3_Human0.87431400
143* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87375029
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86902280
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85717972
146* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84604272
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84273613
148BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82724508
149CHD1_26751641_Chip-Seq_LNCaP_Human0.81238375
150VDR_21846776_ChIP-Seq_THP-1_Human0.80574673
151NANOG_16153702_ChIP-ChIP_HESCs_Human0.79234274
152NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79112777
153SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77939405
154SPI1_23547873_ChIP-Seq_NB4_Human0.77620483
155GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77500132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.46636313
2MP0010094_abnormal_chromosome_stability4.02366926
3MP0003950_abnormal_plasma_membrane3.83087764
4MP0003111_abnormal_nucleus_morphology3.63099686
5MP0004957_abnormal_blastocyst_morpholog3.56922292
6MP0008057_abnormal_DNA_replication3.45218253
7MP0003077_abnormal_cell_cycle3.39606098
8MP0010234_abnormal_vibrissa_follicle3.10920753
9MP0008007_abnormal_cellular_replicative2.68851337
10MP0008058_abnormal_DNA_repair2.52817539
11MP0010352_gastrointestinal_tract_polyps2.42543924
12MP0002396_abnormal_hematopoietic_system2.31948192
13MP0001730_embryonic_growth_arrest2.16679774
14MP0008932_abnormal_embryonic_tissue2.11885724
15MP0000350_abnormal_cell_proliferation2.09740723
16MP0002166_altered_tumor_susceptibility2.00797259
17MP0001835_abnormal_antigen_presentation1.95621229
18MP0003123_paternal_imprinting1.95389952
19MP0010307_abnormal_tumor_latency1.92450863
20MP0003300_gastrointestinal_ulcer1.84903005
21MP0003191_abnormal_cellular_cholesterol1.84165809
22MP0001672_abnormal_embryogenesis/_devel1.81353547
23MP0005380_embryogenesis_phenotype1.81353547
24MP0000490_abnormal_crypts_of1.74016134
25MP0002254_reproductive_system_inflammat1.73890852
26MP0009053_abnormal_anal_canal1.70938549
27MP0003567_abnormal_fetal_cardiomyocyte1.69700933
28MP0003984_embryonic_growth_retardation1.65945696
29MP0003091_abnormal_cell_migration1.65650590
30MP0004197_abnormal_fetal_growth/weight/1.65599336
31MP0000685_abnormal_immune_system1.64749376
32MP0003705_abnormal_hypodermis_morpholog1.64560789
33MP0001697_abnormal_embryo_size1.62966280
34MP0002088_abnormal_embryonic_growth/wei1.62730499
35MP0001853_heart_inflammation1.62347312
36MP0000749_muscle_degeneration1.61461426
37MP0002009_preneoplasia1.60229231
38MP0002085_abnormal_embryonic_tissue1.53730590
39MP0003786_premature_aging1.52445063
40MP0005076_abnormal_cell_differentiation1.52214367
41MP0002084_abnormal_developmental_patter1.50029662
42MP0003303_peritoneal_inflammation1.49748798
43MP0002086_abnormal_extraembryonic_tissu1.48433086
44MP0008877_abnormal_DNA_methylation1.46490481
45MP0002080_prenatal_lethality1.42125316
46MP0004808_abnormal_hematopoietic_stem1.41882073
47MP0000537_abnormal_urethra_morphology1.40196112
48MP0003718_maternal_effect1.39041321
49MP0008438_abnormal_cutaneous_collagen1.36616991
50MP0001873_stomach_inflammation1.36215625
51MP0003453_abnormal_keratinocyte_physiol1.32424682
52MP0002019_abnormal_tumor_incidence1.30927537
53MP0004233_abnormal_muscle_weight1.26486789
54MP0010030_abnormal_orbit_morphology1.24983205
55MP0003806_abnormal_nucleotide_metabolis1.24774588
56MP0003937_abnormal_limbs/digits/tail_de1.23560271
57MP0010678_abnormal_skin_adnexa1.21102636
58MP0005000_abnormal_immune_tolerance1.20436968
59MP0004084_abnormal_cardiac_muscle1.16907017
60MP0009333_abnormal_splenocyte_physiolog1.16774434
61MP0003448_altered_tumor_morphology1.14250636
62MP0003121_genomic_imprinting1.13648185
63MP0004782_abnormal_surfactant_physiolog1.13235415
64MP0005451_abnormal_body_composition1.12623703
65MP0000313_abnormal_cell_death1.12468071
66MP0005387_immune_system_phenotype1.12439027
67MP0001790_abnormal_immune_system1.12439027
68MP0001293_anophthalmia1.10926324
69MP0001800_abnormal_humoral_immune1.10160037
70MP0002210_abnormal_sex_determination1.10051736
71MP0003315_abnormal_perineum_morphology1.08960003
72MP0003890_abnormal_embryonic-extraembry1.08783451
73MP0001545_abnormal_hematopoietic_system1.08150028
74MP0005397_hematopoietic_system_phenotyp1.08150028
75MP0002452_abnormal_antigen_presenting1.07521314
76MP0003763_abnormal_thymus_physiology1.06143139
77MP0009785_altered_susceptibility_to1.05528785
78MP0002148_abnormal_hypersensitivity_rea1.05131761
79MP0004087_abnormal_muscle_fiber1.02715227
80MP0005310_abnormal_salivary_gland1.02078632
81MP0001915_intracranial_hemorrhage0.98047849
82MP0004185_abnormal_adipocyte_glucose0.97050536
83MP0005023_abnormal_wound_healing0.96971302
84MP0006054_spinal_hemorrhage0.96969294
85MP0002060_abnormal_skin_morphology0.96163172
86MP0000767_abnormal_smooth_muscle0.93530064
87MP0002269_muscular_atrophy0.93001764
88MP0002877_abnormal_melanocyte_morpholog0.92652291
89MP0003941_abnormal_skin_development0.92291144
90MP0000733_abnormal_muscle_development0.92036729
91MP0002111_abnormal_tail_morphology0.91771690
92MP0004947_skin_inflammation0.91190322
93MP0009672_abnormal_birth_weight0.91053654
94MP0001216_abnormal_epidermal_layer0.90863084
95MP0009780_abnormal_chondrocyte_physiolo0.89989605
96MP0002796_impaired_skin_barrier0.89968676
97MP0001145_abnormal_male_reproductive0.89434636
98MP0003436_decreased_susceptibility_to0.88514106
99MP0001119_abnormal_female_reproductive0.88229391
100MP0004272_abnormal_basement_membrane0.87870357
101MP0002405_respiratory_system_inflammati0.87374019
102MP0004036_abnormal_muscle_relaxation0.86742983
103MP0005408_hypopigmentation0.86716407
104MP0003566_abnormal_cell_adhesion0.84373136
105MP0002723_abnormal_immune_serum0.84344970
106MP0010155_abnormal_intestine_physiology0.84198981
107MP0001286_abnormal_eye_development0.84103127
108MP0002420_abnormal_adaptive_immunity0.83771126
109MP0000703_abnormal_thymus_morphology0.83757509
110MP0002697_abnormal_eye_size0.83363656
111MP0000428_abnormal_craniofacial_morphol0.83098282
112MP0000759_abnormal_skeletal_muscle0.82414638
113MP0003136_yellow_coat_color0.82129427
114MP0001819_abnormal_immune_cell0.82081450
115MP0000432_abnormal_head_morphology0.81889548
116MP0001929_abnormal_gametogenesis0.81472769
117MP0002398_abnormal_bone_marrow0.81436099
118MP0001661_extended_life_span0.81080396
119MP0010630_abnormal_cardiac_muscle0.81046096
120MP0004264_abnormal_extraembryonic_tissu0.80381207
121MP0002092_abnormal_eye_morphology0.79506832
122MP0000653_abnormal_sex_gland0.79284864
123MP0003119_abnormal_digestive_system0.78962543
124MP0003221_abnormal_cardiomyocyte_apopto0.78675954
125MP0004883_abnormal_blood_vessel0.77729099
126MP0000716_abnormal_immune_system0.77058242
127MP0002160_abnormal_reproductive_system0.75687250
128MP0003868_abnormal_feces_composition0.75676604
129MP0002722_abnormal_immune_system0.75343149
130MP0000750_abnormal_muscle_regeneration0.75162307
131MP0002896_abnormal_bone_mineralization0.75120615
132MP0000858_altered_metastatic_potential0.75071513
133MP0000689_abnormal_spleen_morphology0.75049551
134MP0005501_abnormal_skin_physiology0.75042781
135MP0002419_abnormal_innate_immunity0.74704550
136MP0009703_decreased_birth_body0.73799221
137MP0001849_ear_inflammation0.71556306
138MP0000477_abnormal_intestine_morphology0.70290309
139MP0003935_abnormal_craniofacial_develop0.69915429
140MP0009278_abnormal_bone_marrow0.68061128
141MP0006292_abnormal_olfactory_placode0.67666695
142MP0002925_abnormal_cardiovascular_devel0.64963413
143MP0003755_abnormal_palate_morphology0.63366686
144MP0005389_reproductive_system_phenotype0.61887341
145MP0005621_abnormal_cell_physiology0.61871059
146MP0005384_cellular_phenotype0.59926843
147MP0000627_abnormal_mammary_gland0.59540933
148MP0002095_abnormal_skin_pigmentation0.59270564
149MP0003828_pulmonary_edema0.58927854
150MP0002006_tumorigenesis0.58258175
151MP0005367_renal/urinary_system_phenotyp0.58210653
152MP0000516_abnormal_urinary_system0.58210653
153MP0003115_abnormal_respiratory_system0.58114786
154MP0003936_abnormal_reproductive_system0.57787929
155MP0002429_abnormal_blood_cell0.57711416
156MP0002075_abnormal_coat/hair_pigmentati0.57082442
157MP0001919_abnormal_reproductive_system0.56564209

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.03265735
2Chromsome breakage (HP:0040012)3.74407957
3Asymmetry of the thorax (HP:0001555)3.67087654
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35919451
5Popliteal pterygium (HP:0009756)3.17159967
6Nemaline bodies (HP:0003798)3.17012797
7Impulsivity (HP:0100710)3.15787911
8Subaortic stenosis (HP:0001682)3.13976716
9Abnormality of the left ventricular outflow tract (HP:0011103)3.13976716
10Abnormality of chromosome stability (HP:0003220)3.10671172
11Selective tooth agenesis (HP:0001592)3.08165518
12Breast hypoplasia (HP:0003187)3.01902818
13Patellar aplasia (HP:0006443)2.91829641
14Meckel diverticulum (HP:0002245)2.89675266
15Arterial tortuosity (HP:0005116)2.88153792
16Colon cancer (HP:0003003)2.87604086
17Abnormality of placental membranes (HP:0011409)2.87530617
18Amniotic constriction ring (HP:0009775)2.87530617
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.85943504
20Reticulocytopenia (HP:0001896)2.85263306
21Aplasia/Hypoplasia of the patella (HP:0006498)2.78343725
22Muscle fiber inclusion bodies (HP:0100299)2.71467921
23Microglossia (HP:0000171)2.71353942
24Abnormality of the preputium (HP:0100587)2.70988320
25Abnormality of the ileum (HP:0001549)2.70849325
26Cystic hygroma (HP:0000476)2.69779794
27Medulloblastoma (HP:0002885)2.67826733
28Ependymoma (HP:0002888)2.64864780
29Deviation of the thumb (HP:0009603)2.63701117
30Curly hair (HP:0002212)2.63228749
31Vascular tortuosity (HP:0004948)2.61333205
32Ectopic kidney (HP:0000086)2.60653797
33Exercise-induced myalgia (HP:0003738)2.58476352
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.58151945
35Degeneration of anterior horn cells (HP:0002398)2.57972687
36Abnormality of the anterior horn cell (HP:0006802)2.57972687
37Abnormality of cells of the erythroid lineage (HP:0012130)2.57954160
38Deep philtrum (HP:0002002)2.54810270
39Myelodysplasia (HP:0002863)2.53745272
40Proximal placement of thumb (HP:0009623)2.53563252
41Rhabdomyosarcoma (HP:0002859)2.52234244
42Type 2 muscle fiber atrophy (HP:0003554)2.49140541
43Spondylolisthesis (HP:0003302)2.48414764
44Hyporeflexia of lower limbs (HP:0002600)2.47393893
45Calf muscle hypertrophy (HP:0008981)2.45541925
46Osteolytic defects of the hand bones (HP:0009699)2.44580678
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.44580678
48Muscle hypertrophy of the lower extremities (HP:0008968)2.44300104
49Absent thumb (HP:0009777)2.44104170
50Abnormal number of erythroid precursors (HP:0012131)2.42749606
51Syringomyelia (HP:0003396)2.39788752
52Spinal cord lesions (HP:0100561)2.39788752
53Asymmetric septal hypertrophy (HP:0001670)2.39579469
54Abnormal foot bone ossification (HP:0010675)2.35859559
55Abnormal lung lobation (HP:0002101)2.34599571
56Small intestinal stenosis (HP:0012848)2.31167669
57Duodenal stenosis (HP:0100867)2.31167669
58Insidious onset (HP:0003587)2.28074865
59Termporal pattern (HP:0011008)2.28074865
60Distal lower limb muscle weakness (HP:0009053)2.27053472
61Acute myeloid leukemia (HP:0004808)2.26497657
62Muscle fiber atrophy (HP:0100295)2.26417460
63Carpal bone hypoplasia (HP:0001498)2.26080203
64Subacute progressive viral hepatitis (HP:0006572)2.26065408
65Abnormality of the calcaneus (HP:0008364)2.25843784
66Recurrent viral infections (HP:0004429)2.25532882
67Facial hemangioma (HP:0000329)2.23916394
6811 pairs of ribs (HP:0000878)2.22842514
69Aplasia/hypoplasia of the humerus (HP:0006507)2.22496930
70Absent radius (HP:0003974)2.21133585
71Autoimmune hemolytic anemia (HP:0001890)2.19758803
72Abnormality of the neuromuscular junction (HP:0003398)2.15500919
73Fatigable weakness (HP:0003473)2.15500919
74Ankle contracture (HP:0006466)2.15376354
75Cutaneous melanoma (HP:0012056)2.14692438
76Progressive external ophthalmoplegia (HP:0000590)2.13081194
77Oral leukoplakia (HP:0002745)2.12958251
78Posterior subcapsular cataract (HP:0007787)2.12948944
79Transitional cell carcinoma of the bladder (HP:0006740)2.11303439
80Agnosia (HP:0010524)2.09741975
81Fatigue (HP:0012378)2.09535711
82Supernumerary spleens (HP:0009799)2.09187754
83Exercise-induced muscle cramps (HP:0003710)2.08462325
84Sloping forehead (HP:0000340)2.08439371
85Abnormality of the labia minora (HP:0012880)2.08094550
86Bladder carcinoma (HP:0002862)2.08077074
87Bladder neoplasm (HP:0009725)2.08077074
88Aplasia/Hypoplasia of the sternum (HP:0006714)2.08074778
89Short thumb (HP:0009778)2.06311152
90Neck muscle weakness (HP:0000467)2.06034498
91IgA deficiency (HP:0002720)2.05194679
92Easy fatigability (HP:0003388)2.05167565
93Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04949650
94Short 4th metacarpal (HP:0010044)2.04949650
95Short humerus (HP:0005792)2.04599877
96Aortic aneurysm (HP:0004942)2.02954170
97Atresia of the external auditory canal (HP:0000413)2.02286580
98Neoplasm of the pancreas (HP:0002894)2.01672655
99Squamous cell carcinoma (HP:0002860)2.01579159
100Aplasia involving forearm bones (HP:0009822)2.01052012
101Absent forearm bone (HP:0003953)2.01052012
102Tetraparesis (HP:0002273)2.01007426
103Missing ribs (HP:0000921)1.99902689
104Weak cry (HP:0001612)1.98893245
105Aortic dissection (HP:0002647)1.96589113
106Nephroblastoma (Wilms tumor) (HP:0002667)1.96519425
107Micronodular cirrhosis (HP:0001413)1.92597061
108Ulnar deviation of the wrist (HP:0003049)1.91981443
109Abnormality of the duodenum (HP:0002246)1.91320636
110Gastrointestinal stroma tumor (HP:0100723)1.90946528
111Viral hepatitis (HP:0006562)1.89278061
112Bone marrow hypocellularity (HP:0005528)1.88741947
113Breast carcinoma (HP:0003002)1.88156651
114Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87649664
115Thrombocytosis (HP:0001894)1.87620003
116Amaurosis fugax (HP:0100576)1.86923451
117Embryonal renal neoplasm (HP:0011794)1.85564811
118Calcaneovalgus deformity (HP:0001848)1.84563249
119Capillary hemangiomas (HP:0005306)1.84452460
120Cafe-au-lait spot (HP:0000957)1.83537107
121Increased nuchal translucency (HP:0010880)1.83485796
122Abnormal tarsal ossification (HP:0008369)1.83018308
123Pterygium (HP:0001059)1.82174625
124Premature rupture of membranes (HP:0001788)1.82171907
125Gowers sign (HP:0003391)1.81730324
126Abnormalities of placenta or umbilical cord (HP:0001194)1.81653293
127Reduced subcutaneous adipose tissue (HP:0003758)1.81523475
128Papillary thyroid carcinoma (HP:0002895)1.81424398
129Biliary tract neoplasm (HP:0100574)1.81167400
130Long clavicles (HP:0000890)1.80898471
131Basal cell carcinoma (HP:0002671)1.80757423
132Tracheoesophageal fistula (HP:0002575)1.79812326
133Short 1st metacarpal (HP:0010034)1.78298254
134Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.78298254
135Volvulus (HP:0002580)1.78073624
136Aplastic anemia (HP:0001915)1.76161335
137Multiple enchondromatosis (HP:0005701)1.75438270
138Vacuolated lymphocytes (HP:0001922)1.75020573
139Deformed tarsal bones (HP:0008119)1.73931499
140Type I transferrin isoform profile (HP:0003642)1.73849554
141Rib fusion (HP:0000902)1.73561091
142Macrocytic anemia (HP:0001972)1.73449656
143Leiomyosarcoma (HP:0100243)1.73349036
144Uterine leiomyosarcoma (HP:0002891)1.73349036
145Gastrointestinal carcinoma (HP:0002672)1.72315638
146Malignant gastrointestinal tract tumors (HP:0006749)1.72315638
147Overlapping toe (HP:0001845)1.71071049
148Abnormal number of incisors (HP:0011064)1.71011722
149Abnormality of the astrocytes (HP:0100707)1.70905176
150Astrocytoma (HP:0009592)1.70905176
151Slender long bone (HP:0003100)1.70710895
152Osteomyelitis (HP:0002754)1.70452739
153Trismus (HP:0000211)1.70405604
154Abnormality of the fingertips (HP:0001211)1.70278566
155Uterine neoplasm (HP:0010784)1.69583605
156Abnormality of the carotid arteries (HP:0005344)1.69564250
157Pelvic girdle muscle weakness (HP:0003749)1.68506166
158T lymphocytopenia (HP:0005403)1.68009052
159Premature graying of hair (HP:0002216)1.67383772
160Fused cervical vertebrae (HP:0002949)1.67356590
161Malignant hyperthermia (HP:0002047)1.67195537
162Short palpebral fissure (HP:0012745)1.66580539
163Abnormality of the umbilical cord (HP:0010881)1.66520963
164Stillbirth (HP:0003826)1.66473907
165Bilateral sensorineural hearing impairment (HP:0008619)1.66410986
166Neoplasm of striated muscle (HP:0009728)1.65889978
167Sparse lateral eyebrow (HP:0005338)1.65864973
168Protrusio acetabuli (HP:0003179)1.64533073
169Prominent nose (HP:0000448)1.64263348
170Triphalangeal thumb (HP:0001199)1.64125288
171Lymphoma (HP:0002665)1.64035902
172Clubbing of toes (HP:0100760)1.62953016
173Abnormality of pyrimidine metabolism (HP:0004353)1.62691182
174High pitched voice (HP:0001620)1.62256684
175Cubitus valgus (HP:0002967)1.61692708
176Pili torti (HP:0003777)1.61005929
177Thyroid carcinoma (HP:0002890)1.60811615
178Absent frontal sinuses (HP:0002688)1.57562415
179Dilatation of the ascending aorta (HP:0005111)1.57224481
180Abnormality of T cell number (HP:0011839)1.56214016
181Myocardial infarction (HP:0001658)1.55038382
182Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.53817523
183Resting tremor (HP:0002322)1.53607804
184Mucosal telangiectasiae (HP:0100579)1.53312844
185Conjunctival hamartoma (HP:0100780)1.52008216
186Thin ribs (HP:0000883)1.51657316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.02864530
2WEE13.45698184
3SRPK12.77412571
4MKNK12.75032348
5MKNK22.72052674
6BUB12.60551056
7MST42.56257378
8NEK22.42778653
9EIF2AK12.41873110
10IRAK32.41341933
11CDK122.34233699
12SIK32.28836933
13TTK2.20022083
14LATS12.18415862
15EEF2K2.04921533
16EIF2AK32.03618545
17MAP3K142.00019672
18BRSK21.99588844
19PLK41.87625246
20PIK3CG1.87294513
21PRPF4B1.83660873
22RPS6KB21.83232003
23MAP3K121.72629003
24PLK11.68835681
25CDK71.68452794
26ZAK1.67349390
27ACVR1B1.67327687
28PLK31.66229957
29NME21.62130705
30RPS6KA41.60093263
31SMG11.59651261
32STK31.58414529
33CDK41.57997288
34NEK11.57028277
35TSSK61.55632191
36STK38L1.54378468
37FLT31.54341696
38AURKB1.53874268
39STK101.50388396
40EPHA21.44927192
41PKN21.43587107
42BMPR21.39943931
43TLK11.39942861
44CHEK21.39556499
45ATR1.37668045
46MAP3K81.35736957
47DYRK31.33433203
48TRIB31.31991552
49TRIM281.30522144
50NLK1.30030790
51PIM11.22732643
52VRK11.21336322
53CHEK11.20440818
54PASK1.19492222
55JAK11.18345677
56TGFBR11.16763051
57JAK31.16449675
58STK41.12609884
59TGFBR21.09625508
60STK391.08359343
61LATS21.07190987
62SCYL21.02861795
63CDK61.02641287
64MAP2K31.02286697
65ATM1.00073893
66PIK3CA0.97529080
67MAP3K100.95786480
68FGFR30.94653930
69PDGFRA0.93844910
70AURKA0.91666061
71DMPK0.91595416
72MOS0.89137070
73MELK0.85375317
74NEK90.85135235
75CDK20.81385382
76EIF2AK20.81308230
77TYK20.81110075
78IKBKE0.77097992
79BRD40.76243909
80SIK10.76173981
81TTN0.75387688
82IRAK40.74490611
83MST1R0.69255158
84TAF10.69153153
85CDK80.66662756
86LRRK20.66318302
87BRSK10.66289514
88PDK20.64372381
89PAK20.63925725
90MAP3K130.63533490
91TRPM70.62841370
92CSNK2A20.62776021
93IKBKB0.62479189
94MYLK0.60864381
95CLK10.60798312
96ILK0.60778365
97MTOR0.60712585
98CDK10.60548426
99ROCK20.58953977
100STK240.57344267
101PAK40.56806404
102MARK30.56792603
103TESK20.56528160
104ALK0.56459318
105FGFR40.55835078
106YES10.53476620
107CSNK2A10.52244048
108PIM20.48311825
109FGR0.48272415
110OBSCN0.47572568
111MAP3K30.47087199
112MUSK0.46028990
113FGFR10.45075536
114RPS6KA50.44884317
115PTK20.44534601
116ITK0.43207682
117NUAK10.43160222
118ERBB40.43077041
119TEC0.42886284
120PAK10.42541500
121AKT20.41138521
122CDK90.40618509
123MAP4K10.40352799
124SGK30.39553607
125TNIK0.39029948
126ERBB30.38738833
127CHUK0.37690488
128MAPKAPK30.37285465
129KIT0.36842163
130PDK30.36766544
131PDK40.36766544
132CSF1R0.34482831
133PRKDC0.34376613
134STK160.33135869
135BTK0.32621635
136PBK0.31733745
137MAP3K60.31705995
138MAPK140.31510727
139TAOK20.30737866

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35423256
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63788864
3Mismatch repair_Homo sapiens_hsa034303.63108346
4RNA transport_Homo sapiens_hsa030133.07585284
5One carbon pool by folate_Homo sapiens_hsa006702.99060907
6Spliceosome_Homo sapiens_hsa030402.87302152
7Cell cycle_Homo sapiens_hsa041102.78618731
8Homologous recombination_Homo sapiens_hsa034402.71822006
9Base excision repair_Homo sapiens_hsa034102.63027239
10Nucleotide excision repair_Homo sapiens_hsa034202.54001688
11RNA polymerase_Homo sapiens_hsa030202.52216571
12Non-homologous end-joining_Homo sapiens_hsa034502.26267964
13Ribosome_Homo sapiens_hsa030102.24910858
14Fanconi anemia pathway_Homo sapiens_hsa034602.18661792
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16887942
16Pyrimidine metabolism_Homo sapiens_hsa002401.96248767
17RNA degradation_Homo sapiens_hsa030181.87107071
18mRNA surveillance pathway_Homo sapiens_hsa030151.86966415
19Proteasome_Homo sapiens_hsa030501.86180241
20B cell receptor signaling pathway_Homo sapiens_hsa046621.81776492
21Basal transcription factors_Homo sapiens_hsa030221.80118773
22p53 signaling pathway_Homo sapiens_hsa041151.76716485
23Systemic lupus erythematosus_Homo sapiens_hsa053221.64827490
24Thyroid cancer_Homo sapiens_hsa052161.46028598
25Non-small cell lung cancer_Homo sapiens_hsa052231.36036427
26Renal cell carcinoma_Homo sapiens_hsa052111.34684569
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30220061
28Other glycan degradation_Homo sapiens_hsa005111.29948720
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24348558
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20917528
31Viral carcinogenesis_Homo sapiens_hsa052031.19603835
32Herpes simplex infection_Homo sapiens_hsa051681.19552968
33T cell receptor signaling pathway_Homo sapiens_hsa046601.15936645
34TNF signaling pathway_Homo sapiens_hsa046681.12874685
35MicroRNAs in cancer_Homo sapiens_hsa052061.12580575
36Epstein-Barr virus infection_Homo sapiens_hsa051691.11264477
37Selenocompound metabolism_Homo sapiens_hsa004501.09999619
38Small cell lung cancer_Homo sapiens_hsa052221.07777619
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07361393
40Focal adhesion_Homo sapiens_hsa045101.06850958
41Osteoclast differentiation_Homo sapiens_hsa043801.02104270
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00740490
43Hepatitis C_Homo sapiens_hsa051600.99875901
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.99664945
45Antigen processing and presentation_Homo sapiens_hsa046120.96966263
46Purine metabolism_Homo sapiens_hsa002300.96405149
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95916196
48HTLV-I infection_Homo sapiens_hsa051660.90897982
49TGF-beta signaling pathway_Homo sapiens_hsa043500.87934374
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85838321
51Tuberculosis_Homo sapiens_hsa051520.84728123
52Pentose phosphate pathway_Homo sapiens_hsa000300.81400867
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80279302
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78623840
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77761181
56Prolactin signaling pathway_Homo sapiens_hsa049170.77515643
57Adherens junction_Homo sapiens_hsa045200.77160929
58Basal cell carcinoma_Homo sapiens_hsa052170.75799081
59Hippo signaling pathway_Homo sapiens_hsa043900.75452896
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.74299243
61Vitamin B6 metabolism_Homo sapiens_hsa007500.73914873
62Biosynthesis of amino acids_Homo sapiens_hsa012300.73335149
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.73273539
64Autoimmune thyroid disease_Homo sapiens_hsa053200.73005530
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72141903
66Legionellosis_Homo sapiens_hsa051340.71247574
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.70635321
68Sphingolipid metabolism_Homo sapiens_hsa006000.70395465
69Insulin resistance_Homo sapiens_hsa049310.68381144
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68263760
71Measles_Homo sapiens_hsa051620.67386328
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.66060653
73Malaria_Homo sapiens_hsa051440.65849995
74Oocyte meiosis_Homo sapiens_hsa041140.65748157
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65486484
76Chronic myeloid leukemia_Homo sapiens_hsa052200.65356408
77Viral myocarditis_Homo sapiens_hsa054160.65246173
78Graft-versus-host disease_Homo sapiens_hsa053320.64971460
79Amoebiasis_Homo sapiens_hsa051460.64773989
80VEGF signaling pathway_Homo sapiens_hsa043700.64728755
81Acute myeloid leukemia_Homo sapiens_hsa052210.64158695
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63739097
83Prostate cancer_Homo sapiens_hsa052150.62679389
84Colorectal cancer_Homo sapiens_hsa052100.60952637
85Salmonella infection_Homo sapiens_hsa051320.60882347
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60308625
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.60148240
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60096912
89Inositol phosphate metabolism_Homo sapiens_hsa005620.60025591
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59540622
91Glioma_Homo sapiens_hsa052140.59246219
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58991557
93Primary immunodeficiency_Homo sapiens_hsa053400.56708341
94Type I diabetes mellitus_Homo sapiens_hsa049400.55570317
95Apoptosis_Homo sapiens_hsa042100.55437079
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54452423
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54416785
98Hepatitis B_Homo sapiens_hsa051610.52657600
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.50989503
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49783098
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.48639343
102Hematopoietic cell lineage_Homo sapiens_hsa046400.46299709
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46158047
104Pathways in cancer_Homo sapiens_hsa052000.45282485
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43252007
106Influenza A_Homo sapiens_hsa051640.43100120
107Glutathione metabolism_Homo sapiens_hsa004800.41480630
108Lysine degradation_Homo sapiens_hsa003100.37929021
109Notch signaling pathway_Homo sapiens_hsa043300.37682331
110N-Glycan biosynthesis_Homo sapiens_hsa005100.36953510
111Alcoholism_Homo sapiens_hsa050340.36812384
112Bladder cancer_Homo sapiens_hsa052190.36302471
113HIF-1 signaling pathway_Homo sapiens_hsa040660.36070750
114Endometrial cancer_Homo sapiens_hsa052130.35759365
115Proteoglycans in cancer_Homo sapiens_hsa052050.35206210
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34891049
117Sulfur relay system_Homo sapiens_hsa041220.34286091
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34045169
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.33500843
120Folate biosynthesis_Homo sapiens_hsa007900.32398063
121Shigellosis_Homo sapiens_hsa051310.32308758
122Pancreatic cancer_Homo sapiens_hsa052120.32307381
123Leishmaniasis_Homo sapiens_hsa051400.31991038
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.31799801
125Carbon metabolism_Homo sapiens_hsa012000.31571805
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30165132
127Tight junction_Homo sapiens_hsa045300.29963551
128Hedgehog signaling pathway_Homo sapiens_hsa043400.29775713
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29696301
130mTOR signaling pathway_Homo sapiens_hsa041500.29555948
131Toxoplasmosis_Homo sapiens_hsa051450.27389334
132Wnt signaling pathway_Homo sapiens_hsa043100.27190590
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25867530
134Protein export_Homo sapiens_hsa030600.25014443
135Allograft rejection_Homo sapiens_hsa053300.24546357
136FoxO signaling pathway_Homo sapiens_hsa040680.24492180
137Melanoma_Homo sapiens_hsa052180.24348941

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