CDRT15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synaptic transmission, dopaminergic (GO:0032226)7.39738042
2regulation of phosphoprotein phosphatase activity (GO:0043666)6.73414847
3regulation of oxidative stress-induced neuron death (GO:1903203)6.24873971
4positive regulation of catecholamine secretion (GO:0033605)5.96349771
5nucleosome disassembly (GO:0006337)4.99415771
6protein-DNA complex disassembly (GO:0032986)4.99415771
7L-serine transport (GO:0015825)4.96060171
8binding of sperm to zona pellucida (GO:0007339)4.92730827
9acrosome reaction (GO:0007340)4.88732686
10tongue development (GO:0043586)4.53565111
11serine transport (GO:0032329)4.43821689
12negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.40368560
13regulation of autophagic vacuole assembly (GO:2000785)4.39293979
14male meiosis (GO:0007140)4.29493859
15spermatid development (GO:0007286)4.22595861
16histone H3-K36 demethylation (GO:0070544)4.22251369
17TOR signaling (GO:0031929)4.16777452
18mitochondrion distribution (GO:0048311)4.04315838
19regulation of oxidative phosphorylation (GO:0002082)4.04289034
20negative regulation of activin receptor signaling pathway (GO:0032926)3.96981098
21male sex determination (GO:0030238)3.82173614
22motile cilium assembly (GO:0044458)3.77953037
23histone-serine phosphorylation (GO:0035404)3.67911602
24multicellular organism reproduction (GO:0032504)3.66591901
25coenzyme catabolic process (GO:0009109)3.56570317
26potassium ion export (GO:0071435)3.56326042
27acrosome assembly (GO:0001675)3.51761077
28regulation of vacuole organization (GO:0044088)3.45796769
29Leydig cell differentiation (GO:0033327)3.45268213
30negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.42025804
31negative thymic T cell selection (GO:0045060)3.38540866
32positive regulation of DNA-dependent DNA replication (GO:2000105)3.35445581
33glycogen metabolic process (GO:0005977)3.35111389
34N-terminal protein amino acid acetylation (GO:0006474)3.34231209
35negative regulation of striated muscle cell apoptotic process (GO:0010664)3.33888615
36sperm-egg recognition (GO:0035036)3.31877934
37cellular glucan metabolic process (GO:0006073)3.31795003
38glucan metabolic process (GO:0044042)3.31795003
39activation of protein kinase B activity (GO:0032148)3.25917755
40negative regulation of macroautophagy (GO:0016242)3.22366045
41diacylglycerol metabolic process (GO:0046339)3.19520369
42negative T cell selection (GO:0043383)3.18256995
43mannose metabolic process (GO:0006013)3.16986063
44androgen biosynthetic process (GO:0006702)3.10898856
45DNA synthesis involved in DNA repair (GO:0000731)3.09578201
46heterochromatin organization (GO:0070828)3.09114855
47polyamine biosynthetic process (GO:0006596)3.08928081
48negative regulation of response to reactive oxygen species (GO:1901032)3.08812974
49phospholipid scrambling (GO:0017121)3.07102670
50cell-cell recognition (GO:0009988)3.05682181
51relaxation of smooth muscle (GO:0044557)3.01187874
52cellular response to epidermal growth factor stimulus (GO:0071364)3.00813777
53peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.00793928
54thymic T cell selection (GO:0045061)3.00599985
55signal peptide processing (GO:0006465)2.99486775
56sperm motility (GO:0030317)2.96612196
57regulation of spindle organization (GO:0090224)2.96586653
58regulation of hydrogen peroxide-induced cell death (GO:1903205)2.96224597
59regulation of ARF GTPase activity (GO:0032312)2.91099955
60protein polymerization (GO:0051258)2.89917177
61glutamine family amino acid catabolic process (GO:0009065)2.89249123
62fusion of sperm to egg plasma membrane (GO:0007342)2.87617509
63negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.86397147
64histone exchange (GO:0043486)2.86194514
65single fertilization (GO:0007338)2.85620459
66synapsis (GO:0007129)2.85430820
67cellular response to lithium ion (GO:0071285)2.83374976
68rRNA methylation (GO:0031167)2.79408532
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.79161149
70histone phosphorylation (GO:0016572)2.75721109
71cortical actin cytoskeleton organization (GO:0030866)2.73260645
72regulation of macrophage cytokine production (GO:0010935)2.73119170
73response to acidic pH (GO:0010447)2.72468328
74positive regulation of gamma-delta T cell activation (GO:0046645)2.70179736
753-UTR-mediated mRNA stabilization (GO:0070935)2.66011849
76cytoplasmic mRNA processing body assembly (GO:0033962)2.63079202
77mesenchymal-epithelial cell signaling (GO:0060638)2.62966023
78mRNA cleavage (GO:0006379)2.61288611
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61078900
80positive regulation of glycolytic process (GO:0045821)2.60845115
81organic cation transport (GO:0015695)2.60222511
82cGMP-mediated signaling (GO:0019934)2.59469294
83positive regulation of protein homooligomerization (GO:0032464)2.59194182
84reproduction (GO:0000003)2.57451962
85regulation of protein localization to cell surface (GO:2000008)2.57420748
86T cell selection (GO:0045058)2.56234471
87germ cell development (GO:0007281)2.52801119
88detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.50935273
89histone H3-K9 demethylation (GO:0033169)2.50819994
90poly(A)+ mRNA export from nucleus (GO:0016973)2.50738958
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48730832
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45864260
93negative regulation of cell killing (GO:0031342)2.45864260
94antigen processing and presentation of endogenous antigen (GO:0019883)2.45644173
95protein localization to kinetochore (GO:0034501)2.45237243
96histone lysine demethylation (GO:0070076)2.42973217
97positive regulation of granulocyte differentiation (GO:0030854)2.42835990
98regulation of dopamine secretion (GO:0014059)2.41857788
99protein localization to cell surface (GO:0034394)2.41669735
100positive regulation of protein kinase C signaling (GO:0090037)2.41502896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.84741449
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.94107310
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.79757307
4AR_21909140_ChIP-Seq_LNCAP_Human3.39712427
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.23004630
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.05607434
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.82527343
8E2F7_22180533_ChIP-Seq_HELA_Human2.78137928
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.77627810
10GATA1_22025678_ChIP-Seq_K562_Human2.31770468
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31759027
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.31045676
13MYB_26560356_Chip-Seq_TH1_Human2.24369873
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20521112
15VDR_21846776_ChIP-Seq_THP-1_Human2.07613601
16UTX_26944678_Chip-Seq_JUKART_Human2.05465174
17MYC_22102868_ChIP-Seq_BL_Human2.03307956
18KDM2B_26808549_Chip-Seq_DND41_Human1.93019281
19MAF_26560356_Chip-Seq_TH2_Human1.89318980
20SPI1_23127762_ChIP-Seq_K562_Human1.73930517
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72349119
22VDR_24763502_ChIP-Seq_THP-1_Human1.63893470
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61522226
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.57441135
25IGF1R_20145208_ChIP-Seq_DFB_Human1.56690729
26SPI1_23547873_ChIP-Seq_NB4_Human1.56435779
27MYB_26560356_Chip-Seq_TH2_Human1.55173140
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54455415
29MAF_26560356_Chip-Seq_TH1_Human1.54252422
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53132486
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52617011
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50031822
33LXR_22292898_ChIP-Seq_THP-1_Human1.49705254
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48970042
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.45146737
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44564728
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42670383
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40756933
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37509203
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34069733
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30138986
42SCL_19346495_ChIP-Seq_HPC-7_Human1.29983892
43SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.28939114
44TCF7_22412390_ChIP-Seq_EML_Mouse1.27273849
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27255483
46SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25736539
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.25352535
48SMC4_20622854_ChIP-Seq_HELA_Human1.24177461
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.23133542
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.21913143
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19791617
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15604820
53* RUNX_20019798_ChIP-Seq_JUKART_Human1.14380851
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14091747
55CHD1_26751641_Chip-Seq_LNCaP_Human1.13946815
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.12265127
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.12024476
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11675263
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09095412
60WDR5_24793694_ChIP-Seq_LNCAP_Human1.08710348
61MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06873477
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06610407
63CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05512600
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05406941
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04916245
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04149772
67SPI1_20517297_ChIP-Seq_HL60_Human1.03480643
68CTCF_21964334_Chip-Seq_Bcells_Human1.02661430
69AR_21572438_ChIP-Seq_LNCaP_Human1.02608625
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.01265702
71AHR_22903824_ChIP-Seq_MCF-7_Human1.00837058
72ZNF263_19887448_ChIP-Seq_K562_Human1.00734967
73VDR_24787735_ChIP-Seq_THP-1_Human0.99901898
74NANOG_20526341_ChIP-Seq_ESCs_Human0.99101100
75ELF1_20517297_ChIP-Seq_JURKAT_Human0.98741712
76UBF1/2_26484160_Chip-Seq_HMECs_Human0.98540359
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98130529
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97745758
79TFEB_21752829_ChIP-Seq_HELA_Human0.97423714
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97063153
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96325783
82NCOR1_26117541_ChIP-Seq_K562_Human0.96221955
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94871245
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94549237
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93505424
86P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90894335
87CIITA_25753668_ChIP-Seq_RAJI_Human0.88891006
88GATA3_27048872_Chip-Seq_THYMUS_Human0.88817236
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88565220
90GATA3_26560356_Chip-Seq_TH2_Human0.88306054
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88023907
92BCAT_22108803_ChIP-Seq_LS180_Human0.87794311
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86747506
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85449564
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85190755
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84521460
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84227734
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82185488
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82012050
100P68_20966046_ChIP-Seq_HELA_Human0.81508843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003315_abnormal_perineum_morphology5.11532860
2MP0008057_abnormal_DNA_replication4.88895951
3MP0008004_abnormal_stomach_pH4.81946786
4MP0005410_abnormal_fertilization4.32237806
5MP0002132_abnormal_respiratory_system3.07024237
6MP0003763_abnormal_thymus_physiology2.71422860
7MP0000537_abnormal_urethra_morphology2.66452147
8MP0010368_abnormal_lymphatic_system2.61100527
9MP0003693_abnormal_embryo_hatching2.24496618
10MP0005647_abnormal_sex_gland2.15890202
11MP0005058_abnormal_lysosome_morphology2.13592267
12MP0003077_abnormal_cell_cycle1.85869115
13MP0005499_abnormal_olfactory_system1.85558229
14MP0005394_taste/olfaction_phenotype1.85558229
15MP0003705_abnormal_hypodermis_morpholog1.82798132
16MP0005360_urolithiasis1.77202593
17MP0001849_ear_inflammation1.73072747
18MP0008438_abnormal_cutaneous_collagen1.68559778
19MP0001929_abnormal_gametogenesis1.58627608
20MP0002254_reproductive_system_inflammat1.56906359
21MP0000685_abnormal_immune_system1.53559709
22MP0010094_abnormal_chromosome_stability1.51716586
23MP0001661_extended_life_span1.50519845
24MP0003436_decreased_susceptibility_to1.47906634
25MP0003566_abnormal_cell_adhesion1.46581639
26MP0004264_abnormal_extraembryonic_tissu1.41819629
27MP0002160_abnormal_reproductive_system1.38828882
28MP0003091_abnormal_cell_migration1.38746143
29MP0001348_abnormal_lacrimal_gland1.38478985
30MP0008260_abnormal_autophagy1.34869185
31MP0001790_abnormal_immune_system1.34861401
32MP0005387_immune_system_phenotype1.34861401
33MP0001835_abnormal_antigen_presentation1.31658815
34MP0003111_abnormal_nucleus_morphology1.30265379
35MP0003828_pulmonary_edema1.29931639
36MP0003698_abnormal_male_reproductive1.29801007
37MP0009697_abnormal_copulation1.29171446
38MP0002398_abnormal_bone_marrow1.21835893
39MP0002127_abnormal_cardiovascular_syste1.21374612
40MP0000703_abnormal_thymus_morphology1.13463756
41MP0004272_abnormal_basement_membrane1.13076278
42MP0000749_muscle_degeneration1.12403739
43MP0002420_abnormal_adaptive_immunity1.08603831
44MP0000465_gastrointestinal_hemorrhage1.07962364
45MP0002163_abnormal_gland_morphology1.07693082
46MP0000767_abnormal_smooth_muscle1.06084133
47MP0003300_gastrointestinal_ulcer1.06065004
48MP0001819_abnormal_immune_cell1.05967713
49MP0009053_abnormal_anal_canal1.05941479
50MP0005671_abnormal_response_to1.02135843
51MP0003806_abnormal_nucleotide_metabolis1.00743904
52MP0009840_abnormal_foam_cell1.00219544
53MP0003045_fibrosis0.99912134
54MP0002405_respiratory_system_inflammati0.98090065
55MP0001853_heart_inflammation0.97823100
56MP0001800_abnormal_humoral_immune0.97803457
57MP0005000_abnormal_immune_tolerance0.96388754
58MP0003279_aneurysm0.95971209
59MP0002876_abnormal_thyroid_physiology0.95298984
60MP0010155_abnormal_intestine_physiology0.94606419
61MP0000716_abnormal_immune_system0.93054025
62MP0000490_abnormal_crypts_of0.92157739
63MP0002419_abnormal_innate_immunity0.91208982
64MP0001730_embryonic_growth_arrest0.90875839
65MP0002723_abnormal_immune_serum0.90784500
66MP0005187_abnormal_penis_morphology0.89299199
67MP0002722_abnormal_immune_system0.89287703
68MP0000538_abnormal_urinary_bladder0.88428009
69MP0004808_abnormal_hematopoietic_stem0.87857289
70MP0005409_darkened_coat_color0.85766656
71MP0005076_abnormal_cell_differentiation0.85048988
72MP0002429_abnormal_blood_cell0.84845102
73MP0005025_abnormal_response_to0.84538773
74MP0000350_abnormal_cell_proliferation0.84174166
75MP0001984_abnormal_olfaction0.83693900
76MP0005621_abnormal_cell_physiology0.83032848
77MP0002108_abnormal_muscle_morphology0.82509408
78MP0002166_altered_tumor_susceptibility0.82427972
79MP0002452_abnormal_antigen_presenting0.81093897
80MP0001145_abnormal_male_reproductive0.80520943
81MP0002396_abnormal_hematopoietic_system0.80072493
82MP0004084_abnormal_cardiac_muscle0.77620539
83MP0004381_abnormal_hair_follicle0.75941557
84MP0005464_abnormal_platelet_physiology0.75380098
85MP0004947_skin_inflammation0.74871907
86MP0005330_cardiomyopathy0.74212728
87MP0005451_abnormal_body_composition0.73627655
88MP0008007_abnormal_cellular_replicative0.70865209
89MP0004957_abnormal_blastocyst_morpholog0.68960991
90MP0002210_abnormal_sex_determination0.68886401
91MP0009115_abnormal_fat_cell0.68515833
92MP0003868_abnormal_feces_composition0.66870137
93MP0002822_catalepsy0.65723675
94MP0004484_altered_response_of0.65501374
95MP0002086_abnormal_extraembryonic_tissu0.65195434
96MP0002998_abnormal_bone_remodeling0.64691520
97MP0001346_abnormal_lacrimal_gland0.64597259
98MP0002161_abnormal_fertility/fecundity0.63465059
99MP0000689_abnormal_spleen_morphology0.62519639
100MP0001845_abnormal_inflammatory_respons0.61198008

Predicted human phenotypes

RankGene SetZ-score
1Upper motor neuron abnormality (HP:0002127)6.90607760
2Abnormality of the anterior horn cell (HP:0006802)5.52758073
3Degeneration of anterior horn cells (HP:0002398)5.52758073
4Abnormality of the lower motor neuron (HP:0002366)5.31067747
5Abnormality of the columella (HP:0009929)4.76951551
6Amyotrophic lateral sclerosis (HP:0007354)4.57717965
7Conjunctival telangiectasia (HP:0000524)4.55440159
8Abnormal sex determination (HP:0012244)4.49566345
9Sex reversal (HP:0012245)4.49566345
10Reduced antithrombin III activity (HP:0001976)4.45159868
11Resting tremor (HP:0002322)4.31262398
12Impaired proprioception (HP:0010831)4.04481492
13Colitis (HP:0002583)4.02020536
14Abnormality of the vasculature of the conjunctiva (HP:0008054)3.89455115
15Gonadal dysgenesis (HP:0000133)3.43117885
16Eosinophilia (HP:0001880)3.32658469
17Granulocytopenia (HP:0001913)3.24266538
18Inflammation of the large intestine (HP:0002037)3.24249759
19Gastrointestinal inflammation (HP:0004386)3.20456519
20Gastrointestinal infarctions (HP:0005244)3.17832359
21Self-mutilation (HP:0000742)3.04505168
22Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.01201641
23Thoracic kyphosis (HP:0002942)2.93850491
24Hypergammaglobulinemia (HP:0010702)2.86375083
25Polyneuropathy (HP:0001271)2.78448354
26Facial hemangioma (HP:0000329)2.75432153
27Abnormal hair whorl (HP:0010721)2.74806191
28Centrally nucleated skeletal muscle fibers (HP:0003687)2.66448315
29Spinal rigidity (HP:0003306)2.65677034
30Abnormality of the intrinsic pathway (HP:0010989)2.64891280
31Aortic dissection (HP:0002647)2.58961613
32Germ cell neoplasia (HP:0100728)2.57861998
33Increased IgM level (HP:0003496)2.55931009
34Autoimmune hemolytic anemia (HP:0001890)2.54164029
35Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.48050208
36Spondylolisthesis (HP:0003302)2.47609626
37Prolonged partial thromboplastin time (HP:0003645)2.47104684
38Thoracolumbar scoliosis (HP:0002944)2.39481999
39Deep venous thrombosis (HP:0002625)2.39022649
40Atonic seizures (HP:0010819)2.38275220
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.34276851
42Postural instability (HP:0002172)2.31821261
43Difficulty walking (HP:0002355)2.29649444
44Decreased motor nerve conduction velocity (HP:0003431)2.26951909
45Hypoplasia of the uterus (HP:0000013)2.22971367
46Eczematoid dermatitis (HP:0000976)2.17462810
47Autoimmune thrombocytopenia (HP:0001973)2.17215551
48Cerebral aneurysm (HP:0004944)2.16987984
49Aplasia cutis congenita (HP:0001057)2.16408765
50Abnormality of the frontal sinuses (HP:0002687)2.13231055
51Abnormality of eosinophils (HP:0001879)2.13056192
52Nasal polyposis (HP:0100582)2.12266807
53Clonus (HP:0002169)2.07230844
54Bicuspid aortic valve (HP:0001647)2.05327001
55Intestinal fistula (HP:0100819)2.04528361
56Abnormality of the thoracic spine (HP:0100711)2.04261612
57Rectal fistula (HP:0100590)2.02999331
58Rectovaginal fistula (HP:0000143)2.02999331
59Mucosal telangiectasiae (HP:0100579)2.00100527
60Peritonitis (HP:0002586)1.97068897
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96840559
62Vaginal fistula (HP:0004320)1.96650789
63Infertility (HP:0000789)1.96477031
64Hypoalphalipoproteinemia (HP:0003233)1.96239953
65Abnormality of the nasal mucosa (HP:0000433)1.96184977
66Prolonged bleeding time (HP:0003010)1.95716346
67Capillary hemangiomas (HP:0005306)1.94585328
68Ventricular fibrillation (HP:0001663)1.90558370
69Syringomyelia (HP:0003396)1.90303146
70Spinal cord lesions (HP:0100561)1.90303146
71Ankyloglossia (HP:0010296)1.89961811
72Menorrhagia (HP:0000132)1.84406992
73Atrophy/Degeneration involving motor neurons (HP:0007373)1.83626140
74Urinary urgency (HP:0000012)1.82787015
75Long eyelashes (HP:0000527)1.81474791
76Hyporeflexia of lower limbs (HP:0002600)1.81038662
77Easy fatigability (HP:0003388)1.81012377
78Asymmetry of the thorax (HP:0001555)1.80988009
79Recurrent viral infections (HP:0004429)1.79724272
80Gaze-evoked nystagmus (HP:0000640)1.79653674
81Limb ataxia (HP:0002070)1.76860978
82Pustule (HP:0200039)1.76724650
83Arterial tortuosity (HP:0005116)1.76501344
84Male pseudohermaphroditism (HP:0000037)1.72837588
85Aortic aneurysm (HP:0004942)1.72101140
86Abnormality of the lumbar spine (HP:0100712)1.70616522
87Panhypogammaglobulinemia (HP:0003139)1.70364358
88Hemorrhage of the eye (HP:0011885)1.70204502
89Leukocytosis (HP:0001974)1.68240318
90Prominent nose (HP:0000448)1.67448296
91Abnormal protein glycosylation (HP:0012346)1.67272848
92Abnormal glycosylation (HP:0012345)1.67272848
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67272848
94Abnormal protein N-linked glycosylation (HP:0012347)1.67272848
95Facial diplegia (HP:0001349)1.64743197
96Coxa valga (HP:0002673)1.63782499
97Basal cell carcinoma (HP:0002671)1.63049578
98Premature rupture of membranes (HP:0001788)1.62568851
99Increased variability in muscle fiber diameter (HP:0003557)1.62366165
100Anal stenosis (HP:0002025)1.62039556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK19.35170830
2MARK35.04531410
3INSRR2.82375749
4MAP3K102.64009568
5CDK62.56011210
6PKN22.38898930
7NEK22.11490062
8LATS22.00647887
9CDK41.96415603
10MAP3K131.91462207
11MAP4K11.72260826
12IRAK31.71266556
13GRK61.70459931
14TLK11.62146807
15PRKD31.60385113
16MYLK1.57351663
17EEF2K1.45307691
18ZAK1.39957546
19SIK31.36045463
20TRIB31.31338489
21BCR1.28062517
22RPS6KA51.20853666
23PRKD21.18496484
24PRPF4B1.16352453
25MAP3K11.16081675
26LATS11.14075954
27FGFR41.13893258
28NEK91.13082427
29NME21.08824232
30BTK1.04877765
31ICK1.04340355
32CDK121.03855243
33KSR21.02532500
34STK101.02015737
35BLK0.95316381
36ERN10.95205489
37PAK10.93285270
38HCK0.88814880
39MAP3K30.88036432
40RIPK40.87106413
41CDC42BPA0.86809019
42ARAF0.79047400
43EPHB10.78759006
44RET0.76038504
45SIK10.72572436
46PRKCQ0.70128108
47MELK0.69782705
48TYK20.69458867
49STK380.69386956
50SGK2230.68769396
51SGK4940.68769396
52SMG10.67552193
53MAP3K80.66692032
54CCNB10.66566942
55TTK0.64993857
56BRSK20.61881459
57MOS0.61396097
58NLK0.61311334
59WEE10.61274256
60STK38L0.60793049
61MAPK110.60386542
62PTK2B0.58704912
63STK40.57533434
64BUB10.56789925
65IRAK20.56700305
66PAK20.56663861
67ITK0.53244072
68BRAF0.52489707
69MTOR0.51898873
70FGFR20.51635437
71FES0.51152397
72DYRK30.50854575
73JAK10.50160810
74ZAP700.49514525
75FGFR30.49015117
76TNK20.48038066
77MAPK120.46413068
78SGK30.45527684
79FGR0.45380216
80CDK30.44405557
81PDGFRA0.42723446
82SIK20.41393313
83GRK10.39882888
84SGK20.39526214
85FLT30.36564314
86MAPKAPK20.35112174
87PBK0.34883710
88SYK0.31447811
89MAP3K20.30796741
90ERBB40.29909576
91MAP2K30.29573683
92RPS6KB10.29428303
93RAF10.28192438
94PLK10.28146621
95PRKG20.27272520
96IRAK40.25231767
97CDK140.25012711
98CAMK1D0.24323120
99PDK10.23597331
100JAK20.21975867

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051305.59059078
2Gap junction_Homo sapiens_hsa045403.10549769
3Apoptosis_Homo sapiens_hsa042102.75653072
4Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.15116876
5Hedgehog signaling pathway_Homo sapiens_hsa043402.14172807
6B cell receptor signaling pathway_Homo sapiens_hsa046622.00066787
7Phagosome_Homo sapiens_hsa041451.77008664
8Non-small cell lung cancer_Homo sapiens_hsa052231.63030183
9T cell receptor signaling pathway_Homo sapiens_hsa046601.55303175
10Hepatitis B_Homo sapiens_hsa051611.50333484
11Olfactory transduction_Homo sapiens_hsa047401.48705020
12Prostate cancer_Homo sapiens_hsa052151.44659406
13Systemic lupus erythematosus_Homo sapiens_hsa053221.43978377
14Cell cycle_Homo sapiens_hsa041101.39694862
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38628414
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36352384
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34572239
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25529624
19Measles_Homo sapiens_hsa051621.24435692
20Herpes simplex infection_Homo sapiens_hsa051681.22846715
21Malaria_Homo sapiens_hsa051441.21727732
22Acute myeloid leukemia_Homo sapiens_hsa052211.21661110
23Endometrial cancer_Homo sapiens_hsa052131.19559835
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18332018
25Osteoclast differentiation_Homo sapiens_hsa043801.16394836
26Dorso-ventral axis formation_Homo sapiens_hsa043201.10782078
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.10386130
28Oocyte meiosis_Homo sapiens_hsa041141.09278397
29Primary immunodeficiency_Homo sapiens_hsa053401.07926110
30Alcoholism_Homo sapiens_hsa050341.04912022
31Chronic myeloid leukemia_Homo sapiens_hsa052201.03397277
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.03172686
33Thyroid cancer_Homo sapiens_hsa052160.99921957
34Pancreatic cancer_Homo sapiens_hsa052120.98214149
35mTOR signaling pathway_Homo sapiens_hsa041500.95487806
36FoxO signaling pathway_Homo sapiens_hsa040680.93208506
37Glucagon signaling pathway_Homo sapiens_hsa049220.92001029
38Influenza A_Homo sapiens_hsa051640.90146738
39Leishmaniasis_Homo sapiens_hsa051400.90024311
40Viral carcinogenesis_Homo sapiens_hsa052030.90013361
41Basal transcription factors_Homo sapiens_hsa030220.89727471
42mRNA surveillance pathway_Homo sapiens_hsa030150.89441182
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88866004
44Choline metabolism in cancer_Homo sapiens_hsa052310.87777897
45Other glycan degradation_Homo sapiens_hsa005110.87636289
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86167838
47Glioma_Homo sapiens_hsa052140.84296829
48Nitrogen metabolism_Homo sapiens_hsa009100.83839755
49Arginine biosynthesis_Homo sapiens_hsa002200.81975725
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80823851
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80702358
52TGF-beta signaling pathway_Homo sapiens_hsa043500.78646287
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.76832253
54Tuberculosis_Homo sapiens_hsa051520.75313212
55DNA replication_Homo sapiens_hsa030300.74937378
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72717574
57Colorectal cancer_Homo sapiens_hsa052100.71401505
58Toxoplasmosis_Homo sapiens_hsa051450.70899348
59HTLV-I infection_Homo sapiens_hsa051660.70097169
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69666954
61Glutathione metabolism_Homo sapiens_hsa004800.68748791
62Platelet activation_Homo sapiens_hsa046110.68610051
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67864054
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.67646229
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66751393
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66488504
67Graft-versus-host disease_Homo sapiens_hsa053320.65819078
68TNF signaling pathway_Homo sapiens_hsa046680.64843240
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.63683109
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63334451
71Focal adhesion_Homo sapiens_hsa045100.63324080
72Allograft rejection_Homo sapiens_hsa053300.62816828
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.62452288
74N-Glycan biosynthesis_Homo sapiens_hsa005100.62381707
75Pentose phosphate pathway_Homo sapiens_hsa000300.62242025
76HIF-1 signaling pathway_Homo sapiens_hsa040660.60983460
77MicroRNAs in cancer_Homo sapiens_hsa052060.60845834
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.60474196
79Proteoglycans in cancer_Homo sapiens_hsa052050.60203727
80Autoimmune thyroid disease_Homo sapiens_hsa053200.58915645
81Insulin signaling pathway_Homo sapiens_hsa049100.58826492
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57922659
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57066391
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56335512
85Propanoate metabolism_Homo sapiens_hsa006400.55537060
86Renal cell carcinoma_Homo sapiens_hsa052110.54831992
87Small cell lung cancer_Homo sapiens_hsa052220.53595900
88Complement and coagulation cascades_Homo sapiens_hsa046100.53508482
89PPAR signaling pathway_Homo sapiens_hsa033200.52839197
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.52317028
91VEGF signaling pathway_Homo sapiens_hsa043700.52252526
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51795530
93Legionellosis_Homo sapiens_hsa051340.51643085
94Melanoma_Homo sapiens_hsa052180.51468776
95African trypanosomiasis_Homo sapiens_hsa051430.50661307
96Insulin resistance_Homo sapiens_hsa049310.50516577
97Amoebiasis_Homo sapiens_hsa051460.49077522
98MAPK signaling pathway_Homo sapiens_hsa040100.48638124
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47096031
100Pyruvate metabolism_Homo sapiens_hsa006200.43524268

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