CDR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)9.14465711
2porphyrin-containing compound biosynthetic process (GO:0006779)6.54480382
3heme biosynthetic process (GO:0006783)5.90382112
4tetrapyrrole biosynthetic process (GO:0033014)5.79220352
5erythrocyte maturation (GO:0043249)5.28023589
6nuclear pore organization (GO:0006999)4.98866965
7porphyrin-containing compound metabolic process (GO:0006778)4.80021687
8microtubule depolymerization (GO:0007019)4.64283495
9response to insecticide (GO:0017085)4.56568067
10regulation of rhodopsin mediated signaling pathway (GO:0022400)4.53318254
11rhodopsin mediated signaling pathway (GO:0016056)4.45057842
12iron ion import (GO:0097286)4.44549937
13protein-chromophore linkage (GO:0018298)4.43704764
14hemoglobin metabolic process (GO:0020027)4.41515533
15erythrocyte development (GO:0048821)4.32841131
16heme metabolic process (GO:0042168)4.20089781
17bicarbonate transport (GO:0015701)4.18449328
18COPI coating of Golgi vesicle (GO:0048205)4.13457089
19Golgi transport vesicle coating (GO:0048200)4.13457089
20histone H3-K36 demethylation (GO:0070544)4.10865046
21glomerular visceral epithelial cell development (GO:0072015)4.06642621
22histone H3-K9 demethylation (GO:0033169)3.71455573
23regulation of RNA export from nucleus (GO:0046831)3.66647172
24regulation of telomere maintenance via telomerase (GO:0032210)3.65748839
25response to lead ion (GO:0010288)3.60756907
26retinal cone cell development (GO:0046549)3.60220833
27photoreceptor cell maintenance (GO:0045494)3.48779112
28positive regulation of neurological system process (GO:0031646)3.45568599
29regulation of nucleobase-containing compound transport (GO:0032239)3.44034479
30COPII vesicle coating (GO:0048208)3.42448383
31mitotic sister chromatid cohesion (GO:0007064)3.41282773
32pore complex assembly (GO:0046931)3.37786548
33glomerular epithelial cell development (GO:0072310)3.35896849
34protein K6-linked ubiquitination (GO:0085020)3.30523938
35DNA synthesis involved in DNA repair (GO:0000731)3.28395844
36negative regulation of fibrinolysis (GO:0051918)3.28174249
37positive regulation of extracellular matrix organization (GO:1903055)3.26356042
38DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.25427392
39positive regulation of hormone biosynthetic process (GO:0046886)3.21937898
40regulation of response to osmotic stress (GO:0047484)3.20722008
41tetrapyrrole metabolic process (GO:0033013)3.18604158
42response to methylmercury (GO:0051597)3.15792432
43embryonic process involved in female pregnancy (GO:0060136)3.15064764
44regulation of histone H3-K9 methylation (GO:0051570)3.12616630
45skin morphogenesis (GO:0043589)3.10725633
46negative regulation of histone methylation (GO:0031061)3.10563263
47cellular response to epidermal growth factor stimulus (GO:0071364)3.07707313
48one-carbon compound transport (GO:0019755)3.06469232
49ovulation from ovarian follicle (GO:0001542)3.05741822
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.05171814
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.05171814
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.05171814
53import into cell (GO:0098657)3.04010649
54microtubule polymerization or depolymerization (GO:0031109)3.03995588
55peptidyl-glutamic acid carboxylation (GO:0017187)3.03799958
56protein carboxylation (GO:0018214)3.03799958
57proline biosynthetic process (GO:0006561)3.03178047
58positive regulation of nuclease activity (GO:0032075)3.00977909
59activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.98914675
60phototransduction (GO:0007602)2.97784525
61regulation of sister chromatid cohesion (GO:0007063)2.97188940
62GDP-mannose metabolic process (GO:0019673)2.96724606
63chondrocyte proliferation (GO:0035988)2.96174501
64mitotic sister chromatid segregation (GO:0000070)2.93933961
65pinocytosis (GO:0006907)2.91424545
66detection of light stimulus (GO:0009583)2.90497671
67nucleotide-sugar biosynthetic process (GO:0009226)2.89577297
68regulation of transcription from RNA polymerase I promoter (GO:0006356)2.89349581
69meiotic chromosome segregation (GO:0045132)2.89057679
70photoreceptor cell development (GO:0042461)2.88019799
71phototransduction, visible light (GO:0007603)2.87311675
72regulation of integrin-mediated signaling pathway (GO:2001044)2.86132068
73regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85650298
74DNA damage induced protein phosphorylation (GO:0006975)2.85126492
75DNA damage response, signal transduction resulting in transcription (GO:0042772)2.84594667
76negative regulation of keratinocyte proliferation (GO:0010839)2.81463259
77protein export from nucleus (GO:0006611)2.80077460
78interleukin-6-mediated signaling pathway (GO:0070102)2.78527426
79vitamin A metabolic process (GO:0006776)2.78433867
80notochord development (GO:0030903)2.75855897
81eye photoreceptor cell development (GO:0042462)2.75078541
82regulation of nuclease activity (GO:0032069)2.74981452
83regulation of cholesterol homeostasis (GO:2000188)2.74625203
84monoubiquitinated protein deubiquitination (GO:0035520)2.70190333
85response to epidermal growth factor (GO:0070849)2.70118897
86UDP-N-acetylglucosamine metabolic process (GO:0006047)2.69797338
87endoplasmic reticulum unfolded protein response (GO:0030968)2.69634403
88myoblast migration (GO:0051451)2.67982275
89negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.67388244
90actin filament capping (GO:0051693)2.66394918
91oocyte maturation (GO:0001556)2.66183482
92cellular protein complex localization (GO:0034629)2.64831056
93erythrocyte differentiation (GO:0030218)2.64472279
94response to arsenic-containing substance (GO:0046685)2.64335841
95mitotic metaphase plate congression (GO:0007080)2.62652472
96sister chromatid segregation (GO:0000819)2.62162094
97cellular response to gamma radiation (GO:0071480)2.61344537
98detection of visible light (GO:0009584)2.60867572
99embryonic camera-type eye morphogenesis (GO:0048596)2.60766652
100piRNA metabolic process (GO:0034587)2.58644856
101very-low-density lipoprotein particle assembly (GO:0034379)2.58336102
102negative regulation of DNA repair (GO:0045738)2.57418225
103mitotic chromosome condensation (GO:0007076)2.55991939
104protein localization to chromosome, centromeric region (GO:0071459)2.54902526
105replicative senescence (GO:0090399)2.54810015
106nuclear envelope disassembly (GO:0051081)2.54164899
107membrane disassembly (GO:0030397)2.54164899
108negative regulation of gluconeogenesis (GO:0045721)2.53601205
109synapsis (GO:0007129)2.53273094
110positive regulation of p38MAPK cascade (GO:1900745)2.52267475
111positive regulation of hormone metabolic process (GO:0032352)2.52063017
112regulation of extracellular matrix disassembly (GO:0010715)2.51311437
113ER-nucleus signaling pathway (GO:0006984)2.50498073
114adherens junction assembly (GO:0034333)2.50264815
115protein N-linked glycosylation via asparagine (GO:0018279)2.50115084
116histone lysine demethylation (GO:0070076)2.48319337
117cellular response to unfolded protein (GO:0034620)2.47755424
118peptidyl-asparagine modification (GO:0018196)2.47510161
119focal adhesion assembly (GO:0048041)2.47246564
120cell-substrate adherens junction assembly (GO:0007045)2.47246564
121vesicle coating (GO:0006901)2.46574348
122dopamine biosynthetic process (GO:0042416)2.45312937
123pigment biosynthetic process (GO:0046148)2.45217146
124myeloid cell development (GO:0061515)2.44431202
125regulation of chromatin binding (GO:0035561)2.44253871
126nuclear pore complex assembly (GO:0051292)2.44070867
127RNA stabilization (GO:0043489)2.43307531
128mRNA stabilization (GO:0048255)2.43307531
129negative regulation of actin filament depolymerization (GO:0030835)2.43114585
130tight junction assembly (GO:0070830)2.42005195
131negative regulation of JUN kinase activity (GO:0043508)2.41927190
132regulation of fibrinolysis (GO:0051917)2.41584106
133dorsal/ventral axis specification (GO:0009950)2.41083162
134regulation of mitotic spindle organization (GO:0060236)2.40998274
135response to laminar fluid shear stress (GO:0034616)2.40964547
136histone demethylation (GO:0016577)2.40611614
137negative regulation of viral release from host cell (GO:1902187)2.40480548
138negative regulation of hormone biosynthetic process (GO:0032353)2.39936756
139negative regulation of hormone metabolic process (GO:0032351)2.39936756
140regulation of translation in response to stress (GO:0043555)2.39600243
141protein-lipid complex assembly (GO:0065005)2.38714902
142kinetochore organization (GO:0051383)2.38714507
143regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.38349207
144positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.38349207
145positive regulation of protein import into nucleus, translocation (GO:0033160)2.38345950
146protein dealkylation (GO:0008214)2.38299042
147protein demethylation (GO:0006482)2.38299042
148cellular response to light stimulus (GO:0071482)2.38123085
149metaphase plate congression (GO:0051310)2.38041338
150regulation of hippo signaling (GO:0035330)2.37917358
151detection of light stimulus involved in sensory perception (GO:0050962)2.37543379
152detection of light stimulus involved in visual perception (GO:0050908)2.37543379
153hyaluronan catabolic process (GO:0030214)2.37393540
154regulation of mammary gland epithelial cell proliferation (GO:0033599)2.36849142
155chromatin assembly (GO:0031497)2.36638031
156regulation of apoptotic cell clearance (GO:2000425)2.36604494
157regulation of early endosome to late endosome transport (GO:2000641)2.36574755
158intestinal cholesterol absorption (GO:0030299)2.35637778
159hypotonic response (GO:0006971)2.35410060
160female gonad development (GO:0008585)2.35360773
161mitotic nuclear envelope disassembly (GO:0007077)2.34776902
162regulation of extracellular matrix organization (GO:1903053)2.34282747
163organ or tissue specific immune response (GO:0002251)2.34236827
164basement membrane organization (GO:0071711)2.33830809
165regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.33424428
166regulation of guanylate cyclase activity (GO:0031282)2.32700003
167protein N-linked glycosylation (GO:0006487)2.32313106
168protein localization to chromosome (GO:0034502)2.31254982
169chromosome condensation (GO:0030261)2.31108138
170endodermal cell differentiation (GO:0035987)2.31036519
171regulation of establishment of cell polarity (GO:2000114)2.30646855
172cell-substrate junction assembly (GO:0007044)2.30440981
173paraxial mesoderm development (GO:0048339)2.30371924
174plasma lipoprotein particle assembly (GO:0034377)2.29944869
175positive regulation of insulin receptor signaling pathway (GO:0046628)2.29516258
176positive regulation of chromosome segregation (GO:0051984)2.27057271
177positive regulation of endothelial cell apoptotic process (GO:2000353)2.26958239
178cellular response to topologically incorrect protein (GO:0035967)2.26096332
179nuclear envelope organization (GO:0006998)2.24838193
180negative regulation of fibroblast apoptotic process (GO:2000270)2.23454680
181regulation of histone H3-K27 methylation (GO:0061085)2.22414968
182chromosome organization involved in meiosis (GO:0070192)2.21844355
183stress fiber assembly (GO:0043149)2.21251895
184maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.21052079
185synaptonemal complex assembly (GO:0007130)2.19107377
186proline metabolic process (GO:0006560)2.18693054
187negative regulation of fatty acid transport (GO:2000192)2.18347559
188protein localization to endosome (GO:0036010)2.18346291
189retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.17683425
190cell adhesion mediated by integrin (GO:0033627)2.17526367
191protoporphyrinogen IX metabolic process (GO:0046501)10.2771930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.62692834
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.40921367
3E2F7_22180533_ChIP-Seq_HELA_Human4.11199314
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.93979391
5GATA1_19941826_ChIP-Seq_K562_Human3.43666265
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.28025249
7* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.01456455
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99862634
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.96911526
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.95270007
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.92340801
12GATA1_22025678_ChIP-Seq_K562_Human2.87843403
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.77408229
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.63323049
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.58643316
16MYC_22102868_ChIP-Seq_BL_Human2.48292278
17CLOCK_20551151_ChIP-Seq_293T_Human2.29628139
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28414959
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.27902508
20TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.27292848
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13148779
22GATA2_19941826_ChIP-Seq_K562_Human2.10016517
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07847153
24VDR_22108803_ChIP-Seq_LS180_Human1.98528452
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.97507183
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92653285
27ZNF263_19887448_ChIP-Seq_K562_Human1.88120490
28GATA1_19941827_ChIP-Seq_MEL_Mouse1.78767157
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77035025
30AR_21909140_ChIP-Seq_LNCAP_Human1.75747327
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71636698
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71538593
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.70906641
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.67743751
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61485647
36TCF7_22412390_ChIP-Seq_EML_Mouse1.61271540
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61046026
38* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59032614
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.56510324
40CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.55063100
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.54899272
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.54899272
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.54899272
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54304975
45CJUN_26792858_Chip-Seq_BT549_Human1.54187317
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53859756
47* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53613139
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.53574416
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53342861
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53113185
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51735305
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.50152776
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.49295322
54* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47763810
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47271865
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47236007
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46866879
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45361921
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44181172
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43796102
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42623288
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41740442
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41509764
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41338036
65* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39993541
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39090828
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38194116
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37145822
69IGF1R_20145208_ChIP-Seq_DFB_Human1.33537750
70* MYB_26560356_Chip-Seq_TH1_Human1.33430637
71ATF3_27146783_Chip-Seq_COLON_Human1.32624344
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32448259
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.32346587
74VDR_21846776_ChIP-Seq_THP-1_Human1.31812100
75TBL1_22424771_ChIP-Seq_293T_Human1.31367294
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.30780901
77* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30405421
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.29673928
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28231386
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26719311
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25891859
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.25771538
83TFEB_21752829_ChIP-Seq_HELA_Human1.25195375
84GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.24951913
85CDX2_22108803_ChIP-Seq_LS180_Human1.24143148
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24121585
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23713238
88* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23444256
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22987491
90* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22658188
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22421971
92NFYA_21822215_ChIP-Seq_K562_Human1.21540388
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21496730
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21100157
95MAF_26560356_Chip-Seq_TH1_Human1.21056174
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20995833
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20321292
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20270859
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20067988
100NFYB_21822215_ChIP-Seq_K562_Human1.19946917
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.19813016
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18856348
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18726271
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17458726
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16345157
106RXR_22158963_ChIP-Seq_LIVER_Mouse1.16296271
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15453876
108GATA6_25053715_ChIP-Seq_YYC3_Human1.15260031
109TCF4_18268006_ChIP-ChIP_LS174T_Human1.14326804
110ISL1_27105846_Chip-Seq_CPCs_Mouse1.13741322
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13727472
112HNFA_21074721_ChIP-Seq_CACO-2_Human1.13362973
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12277998
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12206397
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.12168395
116NCOR1_26117541_ChIP-Seq_K562_Human1.11692840
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11178465
118WT1_19549856_ChIP-ChIP_CCG9911_Human1.10821930
119UTX_26944678_Chip-Seq_JUKART_Human1.10544616
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09924851
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09352826
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09204311
123* KDM2B_26808549_Chip-Seq_K562_Human1.08970679
124RACK7_27058665_Chip-Seq_MCF-7_Human1.08199098
125SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08020067
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07790130
127FOXO3_23340844_ChIP-Seq_DLD1_Human1.07570313
128KDM2B_26808549_Chip-Seq_DND41_Human1.07472086
129TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07432178
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07369276
131MYB_26560356_Chip-Seq_TH2_Human1.07066096
132RUNX1_22412390_ChIP-Seq_EML_Mouse1.07001253
133PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06918691
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06792165
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06738819
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06704424
137BRD4_25478319_ChIP-Seq_HGPS_Human1.06558807
138* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06502976
139STAT3_23295773_ChIP-Seq_U87_Human1.05848969
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05744198
141STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05249876
142DCP1A_22483619_ChIP-Seq_HELA_Human1.05141798
143NOTCH1_21737748_ChIP-Seq_TLL_Human1.04692856
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04664918
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02914144
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02704594
147PIAS1_25552417_ChIP-Seq_VCAP_Human1.01581497
148KLF5_25053715_ChIP-Seq_YYC3_Human0.99209609
149ETV1_20927104_ChIP-Seq_GIST48_Human0.97384921
150OCT1_27270436_Chip-Seq_PROSTATE_Human0.96113712
151E2F1_21310950_ChIP-Seq_MCF-7_Human0.95700498
152* GATA4_25053715_ChIP-Seq_YYC3_Human0.95393478
153EZH2_27294783_Chip-Seq_NPCs_Mouse0.95278223
154GF1B_26923725_Chip-Seq_HPCs_Mouse0.95270220
155PHF8_20622853_ChIP-Seq_HELA_Human0.94911123
156GF1_26923725_Chip-Seq_HPCs_Mouse0.93923203
157RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93212988
158CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92744685
159PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92731915
160JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92574905
161* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91859568
162* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91751205
163TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91630692
164NANOG_18555785_Chip-Seq_ESCs_Mouse0.91568164
165NFE2_27457419_Chip-Seq_LIVER_Mouse0.90003800
166TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89371542
167SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89231362
168SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89231362
169PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88141414
170SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87830447
171SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87358943
172TP53_18474530_ChIP-ChIP_U2OS_Human0.86871510
173PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86711965
174YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86711325
175SMAD3_21741376_ChIP-Seq_HESCs_Human0.86542792
176GBX2_23144817_ChIP-Seq_PC3_Human0.86481809
177* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85639864
178ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84522644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level6.45712307
2MP0003656_abnormal_erythrocyte_physiolo5.86154164
3MP0003011_delayed_dark_adaptation3.56106468
4MP0002877_abnormal_melanocyte_morpholog3.11948297
5MP0003111_abnormal_nucleus_morphology2.56613058
6MP0005551_abnormal_eye_electrophysiolog2.47426970
7MP0009840_abnormal_foam_cell2.17243326
8MP0010030_abnormal_orbit_morphology2.05260168
9MP0008438_abnormal_cutaneous_collagen2.02113223
10MP0006072_abnormal_retinal_apoptosis1.95293391
11MP0001730_embryonic_growth_arrest1.90841160
12MP0003950_abnormal_plasma_membrane1.89422130
13MP0005171_absent_coat_pigmentation1.87239911
14MP0004233_abnormal_muscle_weight1.84979133
15MP0003763_abnormal_thymus_physiology1.82695969
16MP0003091_abnormal_cell_migration1.81274401
17MP0005253_abnormal_eye_physiology1.81075016
18MP0004264_abnormal_extraembryonic_tissu1.79495160
19MP0002396_abnormal_hematopoietic_system1.79243660
20MP0009333_abnormal_splenocyte_physiolog1.77367194
21MP0010352_gastrointestinal_tract_polyps1.76146886
22MP0005409_darkened_coat_color1.75244861
23MP0005503_abnormal_tendon_morphology1.71527425
24MP0004957_abnormal_blastocyst_morpholog1.70150053
25MP0005275_abnormal_skin_tensile1.69858858
26MP0005257_abnormal_intraocular_pressure1.69377069
27MP0005360_urolithiasis1.69025658
28MP0002653_abnormal_ependyma_morphology1.62757053
29MP0004134_abnormal_chest_morphology1.60940104
30MP0003693_abnormal_embryo_hatching1.60401173
31MP0006292_abnormal_olfactory_placode1.59572762
32MP0005023_abnormal_wound_healing1.59152728
33MP0004272_abnormal_basement_membrane1.58647357
34MP0005248_abnormal_Harderian_gland1.55033525
35MP0009250_abnormal_appendicular_skeleto1.46483387
36MP0001666_abnormal_nutrient_absorption1.43789223
37MP0005380_embryogenesis_phenotype1.40143160
38MP0001672_abnormal_embryogenesis/_devel1.40143160
39MP0002638_abnormal_pupillary_reflex1.38580932
40MP0003878_abnormal_ear_physiology1.37744424
41MP0005377_hearing/vestibular/ear_phenot1.37744424
42MP0005076_abnormal_cell_differentiation1.37000901
43MP0008995_early_reproductive_senescence1.36968172
44MP0005621_abnormal_cell_physiology1.36132929
45MP0003943_abnormal_hepatobiliary_system1.35556391
46MP0003385_abnormal_body_wall1.35247554
47MP0008260_abnormal_autophagy1.34900057
48MP0003984_embryonic_growth_retardation1.34594661
49MP0002166_altered_tumor_susceptibility1.30412151
50MP0003868_abnormal_feces_composition1.30237413
51MP0003077_abnormal_cell_cycle1.29894635
52MP0003941_abnormal_skin_development1.29850525
53MP0000566_synostosis1.29046706
54MP0003705_abnormal_hypodermis_morpholog1.26552079
55MP0003937_abnormal_limbs/digits/tail_de1.26548231
56MP0002088_abnormal_embryonic_growth/wei1.26376233
57MP0000767_abnormal_smooth_muscle1.25405885
58MP0005058_abnormal_lysosome_morphology1.24865019
59MP0004043_abnormal_pH_regulation1.21909540
60MP0005501_abnormal_skin_physiology1.21152151
61MP0002089_abnormal_postnatal_growth/wei1.17911802
62MP0005623_abnormal_meninges_morphology1.17831928
63MP0010368_abnormal_lymphatic_system1.17797139
64MP0004185_abnormal_adipocyte_glucose1.16515032
65MP0004808_abnormal_hematopoietic_stem1.16052986
66MP0010307_abnormal_tumor_latency1.13642896
67MP0001697_abnormal_embryo_size1.13452121
68MP0003453_abnormal_keratinocyte_physiol1.11960128
69MP0005508_abnormal_skeleton_morphology1.11655747
70MP0006054_spinal_hemorrhage1.11548679
71MP0002080_prenatal_lethality1.11365536
72MP0002009_preneoplasia1.08350510
73MP0000703_abnormal_thymus_morphology1.07157555
74MP0000462_abnormal_digestive_system1.06068888
75MP0000858_altered_metastatic_potential1.05085515
76MP0005195_abnormal_posterior_eye1.05047278
77MP0003566_abnormal_cell_adhesion1.04798865
78MP0000490_abnormal_crypts_of1.04432679
79MP0008877_abnormal_DNA_methylation1.04326686
80MP0003786_premature_aging1.02507907
81MP0005384_cellular_phenotype1.02472470
82MP0000003_abnormal_adipose_tissue1.01749458
83MP0010094_abnormal_chromosome_stability0.99887755
84MP0005187_abnormal_penis_morphology0.97813139
85MP0001879_abnormal_lymphatic_vessel0.97421969
86MP0001849_ear_inflammation0.96119467
87MP0002210_abnormal_sex_determination0.96034404
88MP0005391_vision/eye_phenotype0.96003415
89MP0005464_abnormal_platelet_physiology0.95334442
90MP0001661_extended_life_span0.95216792
91MP0002060_abnormal_skin_morphology0.95169789
92MP0002006_tumorigenesis0.93118682
93MP0008007_abnormal_cellular_replicative0.92717902
94MP0002084_abnormal_developmental_patter0.92533052
95MP0003448_altered_tumor_morphology0.91762743
96MP0002139_abnormal_hepatobiliary_system0.90286224
97MP0005451_abnormal_body_composition0.89111536
98MP0008058_abnormal_DNA_repair0.88791712
99MP0001324_abnormal_eye_pigmentation0.88412200
100MP0005408_hypopigmentation0.88324068
101MP0008789_abnormal_olfactory_epithelium0.88038619
102MP0000613_abnormal_salivary_gland0.88033727
103MP0002116_abnormal_craniofacial_bone0.87307402
104MP0003787_abnormal_imprinting0.87252741
105MP0005636_abnormal_mineral_homeostasis0.87184807
106MP0004019_abnormal_vitamin_homeostasis0.86708822
107MP0000163_abnormal_cartilage_morphology0.85805872
108MP0005083_abnormal_biliary_tract0.85784681
109MP0001299_abnormal_eye_distance/0.84921887
110MP0003172_abnormal_lysosome_physiology0.84531768
111MP0001851_eye_inflammation0.83537063
112MP0001915_intracranial_hemorrhage0.83197290
113MP0003755_abnormal_palate_morphology0.82340549
114MP0000432_abnormal_head_morphology0.81753456
115MP0002398_abnormal_bone_marrow0.81502422
116MP0000685_abnormal_immune_system0.81327869
117MP0008057_abnormal_DNA_replication0.81327338
118MP0001243_abnormal_dermal_layer0.80527506
119MP0009384_cardiac_valve_regurgitation0.80373339
120MP0000350_abnormal_cell_proliferation0.79922870
121MP0000678_abnormal_parathyroid_gland0.79325631
122MP0003123_paternal_imprinting0.78946831
123MP0003890_abnormal_embryonic-extraembry0.78580414
124MP0002102_abnormal_ear_morphology0.78107591
125MP0008932_abnormal_embryonic_tissue0.77864340
126MP0000598_abnormal_liver_morphology0.77544948
127MP0001346_abnormal_lacrimal_gland0.77320835
128MP0001958_emphysema0.77176813
129MP0002896_abnormal_bone_mineralization0.76772843
130MP0003121_genomic_imprinting0.76431218
131MP0000653_abnormal_sex_gland0.76362180
132MP0001929_abnormal_gametogenesis0.75506785
133MP0002019_abnormal_tumor_incidence0.75098946
134MP0001216_abnormal_epidermal_layer0.72967604
135MP0002113_abnormal_skeleton_development0.72661391
136MP0002098_abnormal_vibrissa_morphology0.72508149
137MP0003300_gastrointestinal_ulcer0.72208098
138MP0003283_abnormal_digestive_organ0.72155797
139MP0002086_abnormal_extraembryonic_tissu0.72042757
140MP0000313_abnormal_cell_death0.72006363
141MP0004947_skin_inflammation0.71899328
142MP0002405_respiratory_system_inflammati0.71298251
143MP0002085_abnormal_embryonic_tissue0.70920835
144MP0000477_abnormal_intestine_morphology0.70435151
145MP0002128_abnormal_blood_circulation0.70409417
146MP0000762_abnormal_tongue_morphology0.70167193
147MP0003115_abnormal_respiratory_system0.69996079
148MP0010155_abnormal_intestine_physiology0.69969956
149MP0001191_abnormal_skin_condition0.69927630
150MP0009672_abnormal_birth_weight0.69489465
151MP0002697_abnormal_eye_size0.68679488
152MP0010234_abnormal_vibrissa_follicle0.68472973
153MP0001614_abnormal_blood_vessel0.68225059
154MP0001286_abnormal_eye_development0.68175691
155MP0003279_aneurysm0.67932481
156MP0001784_abnormal_fluid_regulation0.67730521
157MP0000049_abnormal_middle_ear0.67250761
158MP0002925_abnormal_cardiovascular_devel0.66769539
159MP0004197_abnormal_fetal_growth/weight/0.66489102
160MP0001119_abnormal_female_reproductive0.64672599
161MP0005375_adipose_tissue_phenotype0.64558400

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)7.31021733
2Abnormality of the heme biosynthetic pathway (HP:0010472)5.91467000
3Acanthocytosis (HP:0001927)5.48225633
4Protrusio acetabuli (HP:0003179)5.23256401
5Congenital stationary night blindness (HP:0007642)4.99703261
6Bony spicule pigmentary retinopathy (HP:0007737)4.48871238
7Hypochromic microcytic anemia (HP:0004840)4.40798010
8Osteomalacia (HP:0002749)4.40542453
9Pigmentary retinal degeneration (HP:0001146)3.90628159
10Reticulocytosis (HP:0001923)3.84715666
11Deep venous thrombosis (HP:0002625)3.44928818
12Vascular tortuosity (HP:0004948)3.33413168
13Arterial tortuosity (HP:0005116)3.30930496
14Papillary thyroid carcinoma (HP:0002895)3.23125320
15Diaphragmatic weakness (HP:0009113)3.19608291
16Premature rupture of membranes (HP:0001788)3.16671146
17Small epiphyses (HP:0010585)3.15852804
18Chorioretinal atrophy (HP:0000533)3.11673456
19Reduced antithrombin III activity (HP:0001976)3.08959896
20Ileus (HP:0002595)3.04587905
21Ankle contracture (HP:0006466)3.03218847
22Abnormality of macular pigmentation (HP:0008002)3.03083742
23Abnormal rod and cone electroretinograms (HP:0008323)3.00081099
24Vitreoretinal degeneration (HP:0000655)2.97403926
25Pendular nystagmus (HP:0012043)2.94160120
26Scotoma (HP:0000575)2.89800383
27Aortic dissection (HP:0002647)2.89537747
28Upper limb muscle weakness (HP:0003484)2.87897958
29Aortic aneurysm (HP:0004942)2.87879522
30Dyschromatopsia (HP:0007641)2.86337633
31Cupped ribs (HP:0000887)2.86111621
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.76782883
33Attenuation of retinal blood vessels (HP:0007843)2.66743655
34Cholelithiasis (HP:0001081)2.64231260
35Wormian bones (HP:0002645)2.62988523
36Urethral obstruction (HP:0000796)2.61400661
37Central scotoma (HP:0000603)2.55071629
38Vertebral compression fractures (HP:0002953)2.51174333
39Abnormal gallbladder morphology (HP:0012437)2.51016268
40Spinal rigidity (HP:0003306)2.49433742
41Spondylolisthesis (HP:0003302)2.45996392
42Chromsome breakage (HP:0040012)2.45937956
43Syringomyelia (HP:0003396)2.45802202
44Spinal cord lesions (HP:0100561)2.45802202
45Abnormality of chloride homeostasis (HP:0011422)2.44279496
46Abnormality of DNA repair (HP:0003254)2.37831383
47Abnormal tarsal ossification (HP:0008369)2.37356691
48Retinal atrophy (HP:0001105)2.37101256
49Nonimmune hydrops fetalis (HP:0001790)2.35762570
50Cerebellar dysplasia (HP:0007033)2.35394113
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34994105
52Thin bony cortex (HP:0002753)2.34848432
53Abnormality of the acetabulum (HP:0003170)2.32752732
54Abnormal foot bone ossification (HP:0010675)2.32699158
55Abnormality of the thoracic spine (HP:0100711)2.31735872
56Keratoconus (HP:0000563)2.31160716
57Increased corneal curvature (HP:0100692)2.31160716
58Congenital sensorineural hearing impairment (HP:0008527)2.30890205
59Mitral valve prolapse (HP:0001634)2.30131413
60Dilatation of the ascending aorta (HP:0005111)2.29314316
61Abnormality of reticulocytes (HP:0004312)2.27829964
62Prostate neoplasm (HP:0100787)2.26960192
63Heterotopia (HP:0002282)2.24360977
64Type II diabetes mellitus (HP:0005978)2.23877537
65Paralysis (HP:0003470)2.23634444
66Entropion (HP:0000621)2.22267139
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.21459521
68Osteolytic defects of the hand bones (HP:0009699)2.21459521
69Abnormality of the fingertips (HP:0001211)2.18863836
70Biconcave vertebral bodies (HP:0004586)2.18134433
71Abnormality of the common coagulation pathway (HP:0010990)2.17703929
72Prolonged partial thromboplastin time (HP:0003645)2.15786184
73Neoplasm of the adrenal cortex (HP:0100641)2.13517442
74Overlapping toe (HP:0001845)2.13140243
75Broad palm (HP:0001169)2.12447020
76Follicular hyperkeratosis (HP:0007502)2.11276541
77Photophobia (HP:0000613)2.08307421
78Blue sclerae (HP:0000592)2.07332003
79Anterior segment dysgenesis (HP:0007700)2.06616560
80Flat acetabular roof (HP:0003180)2.05208649
81Elbow flexion contracture (HP:0002987)2.04957319
82Delayed closure of the anterior fontanelle (HP:0001476)2.00703890
83Cone-rod dystrophy (HP:0000548)2.00545149
84Subacute progressive viral hepatitis (HP:0006572)2.00527554
85Breast aplasia (HP:0100783)2.00174092
86Flat capital femoral epiphysis (HP:0003370)1.98826155
87Disproportionate tall stature (HP:0001519)1.98765834
88Renal tubular acidosis (HP:0001947)1.98664732
89Hypoplasia of the fovea (HP:0007750)1.98488844
90Aplasia/Hypoplasia of the fovea (HP:0008060)1.98488844
91Hemorrhage of the eye (HP:0011885)1.96120060
92Insomnia (HP:0100785)1.95989567
93Shallow orbits (HP:0000586)1.95203400
94Abnormality of the fovea (HP:0000493)1.93283845
95Dislocated radial head (HP:0003083)1.93229502
96Mitral regurgitation (HP:0001653)1.92597004
97Abnormal ossification of hand bones (HP:0005921)1.92381167
98Ulnar bowing (HP:0003031)1.92352413
99Epiphyseal dysplasia (HP:0002656)1.90322897
100Type I transferrin isoform profile (HP:0003642)1.90102018
101Poikiloderma (HP:0001029)1.89584394
102Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88985649
103Thyroid carcinoma (HP:0002890)1.88954610
104Stillbirth (HP:0003826)1.88819661
105Aplasia/Hypoplasia of the breasts (HP:0010311)1.88705881
106Cerebral aneurysm (HP:0004944)1.87720657
107Menorrhagia (HP:0000132)1.87436491
108Aneurysm (HP:0002617)1.87110410
109Atrophic scars (HP:0001075)1.86184731
110Metabolic alkalosis (HP:0200114)1.85867829
111Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84405317
112Soft skin (HP:0000977)1.83789031
113Adrenal hypoplasia (HP:0000835)1.82906563
114Joint laxity (HP:0001388)1.82368871
115Basal cell carcinoma (HP:0002671)1.81818055
116Fragile skin (HP:0001030)1.81213391
117Asymmetry of the thorax (HP:0001555)1.80805432
118Progressive external ophthalmoplegia (HP:0000590)1.80803314
119Shoulder girdle muscle weakness (HP:0003547)1.80794325
120Delayed epiphyseal ossification (HP:0002663)1.80696058
121Abnormal delivery (HP:0001787)1.79991601
122Abnormality of carpal bone ossification (HP:0006257)1.79592752
123Decreased central vision (HP:0007663)1.79420885
124Thoracic kyphosis (HP:0002942)1.78548920
125Peritonitis (HP:0002586)1.77792131
126Stomach cancer (HP:0012126)1.77250843
127Hepatoblastoma (HP:0002884)1.77169056
128Distal lower limb muscle weakness (HP:0009053)1.76078920
129Difficulty climbing stairs (HP:0003551)1.75796303
130Abnormality of the radial head (HP:0003995)1.75238861
131Metaphyseal irregularity (HP:0003025)1.75141067
132Hypomagnesemia (HP:0002917)1.75074335
133Hypokalemic alkalosis (HP:0001949)1.74478865
134Long eyelashes (HP:0000527)1.73901629
135Lip pit (HP:0100267)1.73191931
136Back pain (HP:0003418)1.72028454
137Limited elbow extension (HP:0001377)1.71563542
138Hyperactive renin-angiotensin system (HP:0000841)1.70981426
139Ectopic kidney (HP:0000086)1.69083363
140Mildly elevated creatine phosphokinase (HP:0008180)1.68258209
141Mitral stenosis (HP:0001718)1.65991017
142Transitional cell carcinoma of the bladder (HP:0006740)1.65878514
143Abnormality of dentin (HP:0010299)1.64744998
144Abnormality of the gallbladder (HP:0005264)1.63900941
145Abnormality of the peritoneum (HP:0002585)1.63605229
146Renal cell carcinoma (HP:0005584)1.63450941
147Aplasia of the phalanges of the hand (HP:0009802)1.62994412
148Aplasia involving bones of the extremities (HP:0009825)1.62994412
149Aplasia involving bones of the upper limbs (HP:0009823)1.62994412
150Choroideremia (HP:0001139)1.62846167
151Subcapsular cataract (HP:0000523)1.62308919
152Autoimmune hemolytic anemia (HP:0001890)1.61993747
153Cardiovascular calcification (HP:0011915)1.61886509
154Hydroxyprolinuria (HP:0003080)1.61564945
155Abnormality of proline metabolism (HP:0010907)1.61564945
156Bladder carcinoma (HP:0002862)1.61543661
157Bladder neoplasm (HP:0009725)1.61543661
158Metaphyseal cupping (HP:0003021)1.61306955
159Fatigue (HP:0012378)1.60745896
160Hypochromic anemia (HP:0001931)1.60622278
161Genu recurvatum (HP:0002816)1.60314816
162Abnormality of the Achilles tendon (HP:0005109)1.60280595
163Nephroblastoma (Wilms tumor) (HP:0002667)1.59988063
164Abnormal hand bone ossification (HP:0010660)1.59561033
165Tetraparesis (HP:0002273)1.59361621
166Insulin-resistant diabetes mellitus (HP:0000831)1.59042271
167Hypobetalipoproteinemia (HP:0003563)1.58483071
168Myocardial infarction (HP:0001658)1.57819200
169Cervical subluxation (HP:0003308)1.57769766
170Embryonal renal neoplasm (HP:0011794)1.57649589
171Bladder diverticulum (HP:0000015)1.57175175
172Hepatocellular carcinoma (HP:0001402)1.57048556
173Abnormal glycosylation (HP:0012345)1.56605235
174Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.56605235
175Abnormal protein N-linked glycosylation (HP:0012347)1.56605235
176Abnormal protein glycosylation (HP:0012346)1.56605235
177Neonatal short-limb short stature (HP:0008921)1.56362579
178Capillary hemangiomas (HP:0005306)1.56058125
179Abnormal urine output (HP:0012590)1.55927457
180Irregular epiphyses (HP:0010582)1.54952114
181Premature skin wrinkling (HP:0100678)1.54371131
182Distal upper limb amyotrophy (HP:0007149)1.54317122
183Upper limb amyotrophy (HP:0009129)1.54317122
184Submucous cleft hard palate (HP:0000176)1.53963038
185Joint hemorrhage (HP:0005261)1.53736961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.44917379
2STK38L3.51011380
3CDK123.05396403
4EIF2AK13.03254304
5ZAK2.98219021
6NEK92.88280171
7PRPF4B2.75073181
8FGFR42.72852170
9FRK2.62572995
10LATS22.52315147
11TSSK62.51313761
12NUAK12.36590932
13WNK42.35632868
14ERN12.31033053
15PBK2.26959498
16GRK12.25283776
17CDC72.24001995
18MAP3K132.22274459
19STK32.20300277
20TTK2.19261599
21TRIB32.09139822
22MAP3K102.05489124
23SMG11.81611681
24CHEK21.80572734
25CDK91.79509693
26PRKD31.69843742
27FGFR31.61626292
28EEF2K1.54007705
29WNK11.52525076
30CAMK1D1.51061097
31STK41.47918127
32MAP3K61.47230605
33ICK1.43486968
34TRPM71.41777677
35CAMK1G1.41351804
36NEK21.40821577
37INSRR1.39418021
38PNCK1.38313653
39EIF2AK31.35855766
40PLK41.31928446
41JAK31.27402834
42ERBB41.27393679
43WNK31.27280883
44TLK11.27173706
45MST1R1.23967016
46MST41.23044052
47SIK11.22904098
48KSR21.22573403
49MELK1.19363275
50MAP2K31.15963391
51PRKAA11.15777871
52SCYL21.15566166
53BRSK11.13728022
54PTK21.12561327
55CDK41.11496056
56IKBKE1.09529920
57PINK11.07507046
58CDK81.06542541
59MAP3K141.06493456
60HIPK21.04462061
61TAOK31.03942178
62TAOK11.03056585
63CSNK1A1L1.03052380
64ARAF1.02866014
65PDGFRB1.02841738
66MET1.01350071
67EPHB21.00989346
68DDR21.00709750
69MAPKAPK50.97202178
70AURKB0.95308894
71CHEK10.92752766
72BRSK20.92159633
73STK100.90808485
74PAK20.90738614
75RIPK10.90679438
76MAP3K90.90250597
77SGK4940.88620809
78SGK2230.88620809
79EPHA20.88306764
80PIM10.87050163
81TIE10.85631630
82YES10.84061273
83ZAP700.83838870
84SGK20.83235073
85STK390.83034770
86ATM0.82841741
87PRKAA20.82725018
88PRKD20.82315889
89DYRK30.81344428
90PKN20.76581461
91TAOK20.75837847
92CSNK1G10.75545401
93PAK40.74900489
94PASK0.74843175
95PLK10.74428540
96AKT30.73664806
97ERBB20.73096606
98TYRO30.72920924
99OXSR10.72127112
100NLK0.71320725
101CLK10.70808456
102AURKA0.70417232
103SGK30.70410508
104PLK30.70408601
105MAP3K30.70368353
106MAP3K10.69510186
107MAP3K20.68614869
108CDC42BPA0.68148803
109RET0.66620790
110TTN0.66472436
111FER0.66095624
112MAP4K10.64942436
113STK380.64910762
114MAP3K80.64817924
115BRD40.64049788
116RPS6KA50.61332175
117NTRK10.60988840
118IRAK30.60401501
119PRKG20.60381376
120MYLK0.59686322
121CDK30.59095581
122MAPK100.56756111
123TYK20.55926454
124CDK60.55832935
125CDK70.55785675
126CSNK1D0.55569893
127BRAF0.53963039
128CSNK1G30.53403115
129WEE10.53044714
130PDK20.52965389
131BMX0.51607041
132ATR0.51209519
133SRPK10.50879244
134TNK20.49803039
135PDGFRA0.49717799
136VRK10.48208607
137NEK60.48153534
138SIK30.47670317
139MAPK110.46264769
140MARK30.45972141
141MOS0.43981556
142MAP3K50.43533197
143ITK0.42668103
144MKNK20.42286582
145AKT10.41988657
146CSNK1G20.41715238
147SGK10.41635630
148CDK10.41487657
149RAF10.41125740
150FGFR10.40733752
151DYRK1B0.39398675
152STK240.39128998
153IKBKB0.37970251
154PTK60.37905241
155CSNK1A10.37051835
156BMPR1B0.36714412
157ABL20.36505089
158MTOR0.36107255

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.98164324
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.79530244
3Vitamin B6 metabolism_Homo sapiens_hsa007502.66223317
4N-Glycan biosynthesis_Homo sapiens_hsa005102.38096095
5Protein digestion and absorption_Homo sapiens_hsa049742.24674354
6Cell cycle_Homo sapiens_hsa041102.22960253
7Systemic lupus erythematosus_Homo sapiens_hsa053222.18858521
8ECM-receptor interaction_Homo sapiens_hsa045121.91183956
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.72969490
10Mineral absorption_Homo sapiens_hsa049781.63692110
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.61725154
12Bladder cancer_Homo sapiens_hsa052191.60057875
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59459644
14Acute myeloid leukemia_Homo sapiens_hsa052211.55499197
15Vitamin digestion and absorption_Homo sapiens_hsa049771.54497260
16p53 signaling pathway_Homo sapiens_hsa041151.53052905
17Fanconi anemia pathway_Homo sapiens_hsa034601.46791065
18Alcoholism_Homo sapiens_hsa050341.46256626
19ABC transporters_Homo sapiens_hsa020101.41572948
20MicroRNAs in cancer_Homo sapiens_hsa052061.39117711
21TGF-beta signaling pathway_Homo sapiens_hsa043501.39065699
22T cell receptor signaling pathway_Homo sapiens_hsa046601.34876180
23Basal transcription factors_Homo sapiens_hsa030221.29126406
24Malaria_Homo sapiens_hsa051441.28264574
25Measles_Homo sapiens_hsa051621.26332517
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24200254
27B cell receptor signaling pathway_Homo sapiens_hsa046621.23909816
28Hippo signaling pathway_Homo sapiens_hsa043901.23348126
29Adherens junction_Homo sapiens_hsa045201.22758649
30Complement and coagulation cascades_Homo sapiens_hsa046101.20673050
31Sphingolipid metabolism_Homo sapiens_hsa006001.19680039
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.19137688
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19027903
34Prostate cancer_Homo sapiens_hsa052151.18225347
35Small cell lung cancer_Homo sapiens_hsa052221.17311753
36DNA replication_Homo sapiens_hsa030301.10848115
37Circadian rhythm_Homo sapiens_hsa047101.10124105
38Renin-angiotensin system_Homo sapiens_hsa046141.10064175
39Pancreatic cancer_Homo sapiens_hsa052121.08843831
40Endometrial cancer_Homo sapiens_hsa052131.08418203
41Galactose metabolism_Homo sapiens_hsa000521.05668398
42mTOR signaling pathway_Homo sapiens_hsa041501.04647335
43Hematopoietic cell lineage_Homo sapiens_hsa046401.04321735
44VEGF signaling pathway_Homo sapiens_hsa043701.03494195
45Melanoma_Homo sapiens_hsa052181.02851293
46Arachidonic acid metabolism_Homo sapiens_hsa005901.00935065
47Tight junction_Homo sapiens_hsa045301.00815471
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99617733
49Other glycan degradation_Homo sapiens_hsa005110.99219370
50ErbB signaling pathway_Homo sapiens_hsa040120.99196709
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.98474796
52Viral carcinogenesis_Homo sapiens_hsa052030.98093798
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97504182
54Focal adhesion_Homo sapiens_hsa045100.97490128
55Dorso-ventral axis formation_Homo sapiens_hsa043200.94780049
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93909060
57Hepatitis C_Homo sapiens_hsa051600.92372512
58Fat digestion and absorption_Homo sapiens_hsa049750.92024794
59Shigellosis_Homo sapiens_hsa051310.90869611
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89440875
61Influenza A_Homo sapiens_hsa051640.88398318
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86671465
63FoxO signaling pathway_Homo sapiens_hsa040680.86200067
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85622225
65Fructose and mannose metabolism_Homo sapiens_hsa000510.84786719
66Base excision repair_Homo sapiens_hsa034100.84725329
67Mismatch repair_Homo sapiens_hsa034300.83616637
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83588564
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82593831
70mRNA surveillance pathway_Homo sapiens_hsa030150.82318009
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82152997
72RNA degradation_Homo sapiens_hsa030180.81861370
73Chronic myeloid leukemia_Homo sapiens_hsa052200.80643929
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80053983
75Sulfur metabolism_Homo sapiens_hsa009200.79933139
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79668508
77Basal cell carcinoma_Homo sapiens_hsa052170.79393562
78TNF signaling pathway_Homo sapiens_hsa046680.77411440
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.76494049
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76027288
81Spliceosome_Homo sapiens_hsa030400.75690721
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75515677
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.75312630
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75117341
85Selenocompound metabolism_Homo sapiens_hsa004500.72782375
86Prion diseases_Homo sapiens_hsa050200.70254749
87One carbon pool by folate_Homo sapiens_hsa006700.69927322
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69054315
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68607897
90HIF-1 signaling pathway_Homo sapiens_hsa040660.68104493
91Linoleic acid metabolism_Homo sapiens_hsa005910.67780700
92Ether lipid metabolism_Homo sapiens_hsa005650.66431251
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66381102
94Nucleotide excision repair_Homo sapiens_hsa034200.65969629
95Thyroid cancer_Homo sapiens_hsa052160.65791301
96Epstein-Barr virus infection_Homo sapiens_hsa051690.64986193
97Glutathione metabolism_Homo sapiens_hsa004800.62566642
98Insulin signaling pathway_Homo sapiens_hsa049100.59544752
99Choline metabolism in cancer_Homo sapiens_hsa052310.59443612
100Estrogen signaling pathway_Homo sapiens_hsa049150.59204502
101HTLV-I infection_Homo sapiens_hsa051660.58976418
102Pathways in cancer_Homo sapiens_hsa052000.58825404
103Toxoplasmosis_Homo sapiens_hsa051450.58601897
104Proteoglycans in cancer_Homo sapiens_hsa052050.58563699
105Ovarian steroidogenesis_Homo sapiens_hsa049130.58484292
106Hepatitis B_Homo sapiens_hsa051610.57547408
107Wnt signaling pathway_Homo sapiens_hsa043100.56893382
108Prolactin signaling pathway_Homo sapiens_hsa049170.56848839
109Lysine degradation_Homo sapiens_hsa003100.55649676
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54874376
111Apoptosis_Homo sapiens_hsa042100.54579120
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54392581
113Homologous recombination_Homo sapiens_hsa034400.54276256
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.54066076
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53759152
116Insulin resistance_Homo sapiens_hsa049310.53354714
117Collecting duct acid secretion_Homo sapiens_hsa049660.53328589
118Inositol phosphate metabolism_Homo sapiens_hsa005620.53208246
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.53176180
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52387522
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52376418
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51817592
123Oocyte meiosis_Homo sapiens_hsa041140.51642360
124AMPK signaling pathway_Homo sapiens_hsa041520.50839361
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50805345
126Endocytosis_Homo sapiens_hsa041440.50790099
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.50159869
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49833767
129Glioma_Homo sapiens_hsa052140.49540904
130Non-small cell lung cancer_Homo sapiens_hsa052230.46560251
131Renal cell carcinoma_Homo sapiens_hsa052110.46559427
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46444024
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46369550
134Thyroid hormone synthesis_Homo sapiens_hsa049180.45835494
135Colorectal cancer_Homo sapiens_hsa052100.45265354
136Herpes simplex infection_Homo sapiens_hsa051680.44171813
137MAPK signaling pathway_Homo sapiens_hsa040100.43106352
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41831155
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40831335
140Purine metabolism_Homo sapiens_hsa002300.39674107
141Hedgehog signaling pathway_Homo sapiens_hsa043400.39058232
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39051851
143Amoebiasis_Homo sapiens_hsa051460.38602048
144RNA transport_Homo sapiens_hsa030130.34845468
145Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34588623

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