CDKN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.90254753
2protein localization to chromosome, centromeric region (GO:0071459)5.60301332
3protein localization to kinetochore (GO:0034501)5.49467415
4mitotic sister chromatid segregation (GO:0000070)5.44169736
5kinetochore assembly (GO:0051382)5.22010361
6mitotic metaphase plate congression (GO:0007080)5.15065924
7CENP-A containing nucleosome assembly (GO:0034080)5.09973165
8attachment of spindle microtubules to kinetochore (GO:0008608)4.98525446
9chromatin remodeling at centromere (GO:0031055)4.97729857
10sister chromatid segregation (GO:0000819)4.97439975
11establishment of chromosome localization (GO:0051303)4.91842204
12proteasome assembly (GO:0043248)4.81469117
13ribosomal small subunit assembly (GO:0000028)4.80918801
14establishment of integrated proviral latency (GO:0075713)4.76737515
15metaphase plate congression (GO:0051310)4.76664299
16microtubule depolymerization (GO:0007019)4.71895234
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.65291741
18mitotic chromosome condensation (GO:0007076)4.60928710
19histone exchange (GO:0043486)4.49691853
20DNA replication-independent nucleosome organization (GO:0034724)4.40687312
21DNA replication-independent nucleosome assembly (GO:0006336)4.40687312
22meiotic chromosome segregation (GO:0045132)4.39442195
23regulation of spindle organization (GO:0090224)4.20050728
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.11751613
25negative regulation of ligase activity (GO:0051352)4.11751613
26chromosome condensation (GO:0030261)4.05193977
27telomere maintenance via semi-conservative replication (GO:0032201)3.92894074
28acrosome assembly (GO:0001675)3.89618715
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.89089741
30DNA strand elongation involved in DNA replication (GO:0006271)3.88372118
31establishment of viral latency (GO:0019043)3.87861485
32viral transcription (GO:0019083)3.81097370
33chromosome segregation (GO:0007059)3.79455440
34spindle checkpoint (GO:0031577)3.77806826
35translational termination (GO:0006415)3.74548532
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.72209366
37telomere maintenance via recombination (GO:0000722)3.70871214
38DNA strand elongation (GO:0022616)3.69774155
39DNA topological change (GO:0006265)3.68733336
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.67206385
41mitotic recombination (GO:0006312)3.65824441
42DNA packaging (GO:0006323)3.65609581
43regulation of chromosome segregation (GO:0051983)3.63173930
44protein localization to chromosome (GO:0034502)3.60123404
45regulation of mitotic spindle organization (GO:0060236)3.58978040
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.58531221
47DNA ligation (GO:0006266)3.56001751
48mitotic nuclear envelope disassembly (GO:0007077)3.55492762
49maturation of SSU-rRNA (GO:0030490)3.55244486
50sperm-egg recognition (GO:0035036)3.54741324
51DNA replication-dependent nucleosome organization (GO:0034723)3.51922013
52DNA replication-dependent nucleosome assembly (GO:0006335)3.51922013
53ventricular cardiac muscle cell development (GO:0055015)3.51350603
54regulation of ubiquitin-protein transferase activity (GO:0051438)3.50354184
55positive regulation of ligase activity (GO:0051351)3.50186934
56ribosomal small subunit biogenesis (GO:0042274)3.49882839
57negative regulation of mitosis (GO:0045839)3.45557557
58ribosomal large subunit biogenesis (GO:0042273)3.43628357
59spindle assembly checkpoint (GO:0071173)3.42130770
60binding of sperm to zona pellucida (GO:0007339)3.38730075
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37365921
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37365921
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37365921
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36723719
65regulation of ligase activity (GO:0051340)3.36667184
66negative regulation of sister chromatid segregation (GO:0033046)3.35564953
67negative regulation of mitotic sister chromatid separation (GO:2000816)3.35564953
68negative regulation of mitotic sister chromatid segregation (GO:0033048)3.35564953
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.35564953
70regulation of cellular amino acid metabolic process (GO:0006521)3.35542100
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.35438504
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.35438504
73negative regulation of chromosome segregation (GO:0051985)3.34179088
74DNA replication checkpoint (GO:0000076)3.33929767
75translational elongation (GO:0006414)3.32520183
76chaperone-mediated protein transport (GO:0072321)3.32514502
77signal transduction involved in DNA damage checkpoint (GO:0072422)3.31272890
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.31272890
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30417859
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.30384703
81ribosome assembly (GO:0042255)3.29838334
82deoxyribonucleotide biosynthetic process (GO:0009263)3.28818193
83cotranslational protein targeting to membrane (GO:0006613)3.27078821
84DNA replication initiation (GO:0006270)3.26870590
85membrane disassembly (GO:0030397)3.26096698
86nuclear envelope disassembly (GO:0051081)3.26096698
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.25401785
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24482208
89fusion of sperm to egg plasma membrane (GO:0007342)3.24252540
90positive regulation of chromosome segregation (GO:0051984)3.22394852
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.21938497
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.21616196
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.21616196
94positive regulation of mitotic sister chromatid separation (GO:1901970)3.21616196
95ATP synthesis coupled proton transport (GO:0015986)3.20329148
96energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20329148
97protein targeting to ER (GO:0045047)3.20279917
98mitotic spindle assembly checkpoint (GO:0007094)3.20123492
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19727693
100regulation of mitotic sister chromatid separation (GO:0010965)3.19199792
101regulation of mitotic sister chromatid segregation (GO:0033047)3.19199792
102regulation of sister chromatid segregation (GO:0033045)3.19199792
103purine nucleobase biosynthetic process (GO:0009113)3.19126068
104mitotic spindle checkpoint (GO:0071174)3.18363937
105telomere maintenance via telomere lengthening (GO:0010833)3.16150484
106cell-cell recognition (GO:0009988)3.15888949
107chromatin assembly or disassembly (GO:0006333)3.14985700
108regulation of mitochondrial translation (GO:0070129)3.13931615
109ATP-dependent chromatin remodeling (GO:0043044)3.13811840
110cellular protein complex disassembly (GO:0043624)3.13524548
111protein K6-linked ubiquitination (GO:0085020)3.13478341
112cell wall macromolecule metabolic process (GO:0044036)3.12849706
113cell wall macromolecule catabolic process (GO:0016998)3.12849706
114nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11764558
115regulation of centriole replication (GO:0046599)3.11223352
116* cell cycle G1/S phase transition (GO:0044843)3.10003230
117* G1/S transition of mitotic cell cycle (GO:0000082)3.10003230
118translational initiation (GO:0006413)3.08523912
119nucleobase-containing small molecule interconversion (GO:0015949)3.07569172
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05927340
121histone-serine phosphorylation (GO:0035404)3.05483515
122regulation of centrosome cycle (GO:0046605)3.04283237
123nuclear pore complex assembly (GO:0051292)3.03784180
124mitotic G2/M transition checkpoint (GO:0044818)3.03742960
125regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02422762
126regulation of mitotic spindle checkpoint (GO:1903504)3.02422762
127negative regulation of nuclear division (GO:0051784)3.01963407
128establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01826754
129protein localization to endoplasmic reticulum (GO:0070972)3.01542981
130DNA unwinding involved in DNA replication (GO:0006268)3.00498891
131regulation of spindle checkpoint (GO:0090231)2.99986671
132nucleotide-excision repair, DNA gap filling (GO:0006297)2.98388566
133mitotic cell cycle (GO:0000278)2.96714215
134regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96114692
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92891726
136viral life cycle (GO:0019058)2.89821842
137regulation of exit from mitosis (GO:0007096)2.88292950
138mitotic sister chromatid cohesion (GO:0007064)2.85805437
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85678208
140protein complex disassembly (GO:0043241)2.85429783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.46203540
2* FOXM1_23109430_ChIP-Seq_U2OS_Human7.33148069
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.53205160
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.43789145
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.18090232
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43190472
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.38138882
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36219690
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.72645162
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.53448035
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50387822
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44683015
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37019356
14AR_21909140_ChIP-Seq_LNCAP_Human2.36743689
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33314165
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30359390
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27969218
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.26394293
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25819911
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23283333
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15363208
22XRN2_22483619_ChIP-Seq_HELA_Human2.10612117
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10463241
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07624894
25VDR_23849224_ChIP-Seq_CD4+_Human2.06247196
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04086810
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92496070
28FOXP3_21729870_ChIP-Seq_TREG_Human1.91876153
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91754103
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89604267
31DCP1A_22483619_ChIP-Seq_HELA_Human1.87661578
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.87309040
33TTF2_22483619_ChIP-Seq_HELA_Human1.71002681
34ELK1_19687146_ChIP-ChIP_HELA_Human1.67188540
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66189971
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64310521
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62063777
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60206612
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59824760
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58632340
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49102583
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48655407
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.47265489
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46501620
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45865610
46GABP_19822575_ChIP-Seq_HepG2_Human1.45148090
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43818010
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40664286
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39305413
50CIITA_25753668_ChIP-Seq_RAJI_Human1.31402693
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31043795
52SPI1_23547873_ChIP-Seq_NB4_Human1.26480934
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26183280
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.24482113
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.23201420
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22908953
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19786826
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.19672659
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18889488
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15833516
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15484158
62KDM5A_27292631_Chip-Seq_BREAST_Human1.14863584
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14396417
64* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13668063
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13604468
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09506595
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08030890
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.06882388
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05366032
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04402509
71* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03142456
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.02443061
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01711101
74VDR_21846776_ChIP-Seq_THP-1_Human1.01674324
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00837652
76MYC_18940864_ChIP-ChIP_HL60_Human1.00072490
77MYC_22102868_ChIP-Seq_BL_Human0.97018745
78NANOG_16153702_ChIP-ChIP_HESCs_Human0.96821242
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96777273
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95943681
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94076558
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93663818
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90580729
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88966212
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88498408
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87527756
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87451714
88KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86866372
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86146217
90* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85610710
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85031514
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84269095
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.84206614
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83957766
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83542766
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.83074446
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81494234
98BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81446157
99MYB_26560356_Chip-Seq_TH2_Human0.81060355
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80765473
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78414901
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78087967
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77923618
104IRF8_22096565_ChIP-ChIP_GC-B_Human0.76843916
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75438195
106RUNX1_22412390_ChIP-Seq_EML_Mouse0.74673316
107TFEB_21752829_ChIP-Seq_HELA_Human0.74097954
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72501080
109SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71569925
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69865161
111* MYB_26560356_Chip-Seq_TH1_Human0.69761642
112* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69720165
113POU5F1_16153702_ChIP-ChIP_HESCs_Human0.68812673
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.68722789
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68335237
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.67752956
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67633872
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67333501
119UTX_26944678_Chip-Seq_JUKART_Human0.66462779
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.66158576
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.65021256
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.64633158
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.62855067
124* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.62620244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.82873370
2MP0003111_abnormal_nucleus_morphology4.68608131
3MP0010094_abnormal_chromosome_stability4.47555257
4MP0004957_abnormal_blastocyst_morpholog3.98589660
5MP0003077_abnormal_cell_cycle3.97505249
6MP0005410_abnormal_fertilization3.80635350
7MP0003806_abnormal_nucleotide_metabolis3.68979489
8MP0008057_abnormal_DNA_replication3.49100741
9MP0008058_abnormal_DNA_repair2.97327977
10MP0008007_abnormal_cellular_replicative2.77629938
11MP0009697_abnormal_copulation2.72817430
12MP0000372_irregular_coat_pigmentation2.41876602
13MP0002396_abnormal_hematopoietic_system2.27698439
14MP0008877_abnormal_DNA_methylation2.25706353
15MP0008932_abnormal_embryonic_tissue2.24048955
16MP0005408_hypopigmentation2.08021202
17MP0001929_abnormal_gametogenesis2.06443035
18MP0003941_abnormal_skin_development1.94796384
19MP0001835_abnormal_antigen_presentation1.91106215
20MP0003656_abnormal_erythrocyte_physiolo1.85637095
21MP0002938_white_spotting1.85103196
22MP0010307_abnormal_tumor_latency1.82378735
23MP0003136_yellow_coat_color1.78305464
24MP0010030_abnormal_orbit_morphology1.77294209
25MP0000490_abnormal_crypts_of1.75142494
26MP0004808_abnormal_hematopoietic_stem1.72157315
27MP0001730_embryonic_growth_arrest1.69928967
28MP0003786_premature_aging1.69664465
29MP0005397_hematopoietic_system_phenotyp1.67288103
30MP0001545_abnormal_hematopoietic_system1.67288103
31MP0003698_abnormal_male_reproductive1.66446492
32MP0009379_abnormal_foot_pigmentation1.66431620
33MP0002210_abnormal_sex_determination1.66273572
34MP0000350_abnormal_cell_proliferation1.65359080
35MP0001293_anophthalmia1.64941251
36MP0006035_abnormal_mitochondrial_morpho1.60550042
37MP0006292_abnormal_olfactory_placode1.58462584
38MP0002398_abnormal_bone_marrow1.56342919
39MP0002132_abnormal_respiratory_system1.54112109
40MP0002019_abnormal_tumor_incidence1.51877024
41MP0000313_abnormal_cell_death1.47793555
42MP0001145_abnormal_male_reproductive1.45695746
43MP0003436_decreased_susceptibility_to1.45214629
44MP0003763_abnormal_thymus_physiology1.43147870
45MP0003186_abnormal_redox_activity1.43031259
46MP0009785_altered_susceptibility_to1.38939619
47MP0000858_altered_metastatic_potential1.38182904
48MP0009333_abnormal_splenocyte_physiolog1.36546398
49MP0002722_abnormal_immune_system1.36543980
50MP0005171_absent_coat_pigmentation1.33210579
51MP0000689_abnormal_spleen_morphology1.31228394
52MP0001529_abnormal_vocalization1.31077630
53MP0001853_heart_inflammation1.29440088
54MP0002405_respiratory_system_inflammati1.26813406
55MP0001800_abnormal_humoral_immune1.25811648
56MP0002452_abnormal_antigen_presenting1.25699122
57MP0002877_abnormal_melanocyte_morpholog1.25482513
58MP0000703_abnormal_thymus_morphology1.25240152
59MP0000653_abnormal_sex_gland1.25135457
60MP0002429_abnormal_blood_cell1.24286744
61MP0002420_abnormal_adaptive_immunity1.24219476
62MP0001819_abnormal_immune_cell1.22899862
63MP0003937_abnormal_limbs/digits/tail_de1.22372836
64MP0005025_abnormal_response_to1.21921409
65MP0002148_abnormal_hypersensitivity_rea1.21844603
66MP0001697_abnormal_embryo_size1.21193839
67MP0005000_abnormal_immune_tolerance1.18803450
68MP0003123_paternal_imprinting1.18654900
69MP0000716_abnormal_immune_system1.17595973
70MP0005671_abnormal_response_to1.15777059
71MP0002080_prenatal_lethality1.13140903
72MP0000685_abnormal_immune_system1.12420680
73MP0002419_abnormal_innate_immunity1.11987371
74MP0002084_abnormal_developmental_patter1.10401067
75MP0006054_spinal_hemorrhage1.09569378
76MP0004147_increased_porphyrin_level1.09536610
77MP0002723_abnormal_immune_serum1.07540060
78MP0005380_embryogenesis_phenotype1.07397680
79MP0001672_abnormal_embryogenesis/_devel1.07397680
80MP0005464_abnormal_platelet_physiology1.03755310
81MP0002161_abnormal_fertility/fecundity1.01148674
82MP0003315_abnormal_perineum_morphology0.99354794
83MP0003984_embryonic_growth_retardation0.97728637
84MP0003890_abnormal_embryonic-extraembry0.97504559
85MP0002088_abnormal_embryonic_growth/wei0.92723771
86MP0005075_abnormal_melanosome_morpholog0.92514731
87MP0002086_abnormal_extraembryonic_tissu0.90932996
88MP0003718_maternal_effect0.90810037
89MP0010155_abnormal_intestine_physiology0.89101453
90MP0005174_abnormal_tail_pigmentation0.89045468
91MP0002095_abnormal_skin_pigmentation0.88144736
92MP0009672_abnormal_birth_weight0.86957983
93MP0002697_abnormal_eye_size0.86414562
94MP0008789_abnormal_olfactory_epithelium0.85161571
95MP0000749_muscle_degeneration0.84385405
96MP0002111_abnormal_tail_morphology0.83730515
97MP0001286_abnormal_eye_development0.82875319
98MP0005395_other_phenotype0.82410941
99MP0006036_abnormal_mitochondrial_physio0.82234801
100MP0010352_gastrointestinal_tract_polyps0.81547518
101MP0002085_abnormal_embryonic_tissue0.80701095
102MP0001119_abnormal_female_reproductive0.79870599
103MP0002166_altered_tumor_susceptibility0.79720116
104MP0005501_abnormal_skin_physiology0.79705033
105MP0002006_tumorigenesis0.78862114
106MP0003567_abnormal_fetal_cardiomyocyte0.76037089
107MP0005076_abnormal_cell_differentiation0.75506974
108MP0001845_abnormal_inflammatory_respons0.74992293
109MP0003448_altered_tumor_morphology0.73565787
110MP0001790_abnormal_immune_system0.72405774
111MP0005387_immune_system_phenotype0.72405774
112MP0002090_abnormal_vision0.72382607
113MP0006072_abnormal_retinal_apoptosis0.72322020
114MP0005384_cellular_phenotype0.70905495
115MP0005389_reproductive_system_phenotype0.70218856
116MP0002233_abnormal_nose_morphology0.70075681
117MP0000647_abnormal_sebaceous_gland0.68007817
118MP0001764_abnormal_homeostasis0.67238020
119MP0005023_abnormal_wound_healing0.66966615
120MP0000537_abnormal_urethra_morphology0.66494386
121MP0000465_gastrointestinal_hemorrhage0.64669993
122MP0002282_abnormal_trachea_morphology0.64164393
123MP0004197_abnormal_fetal_growth/weight/0.63766840
124MP0000358_abnormal_cell_content/0.63411977
125MP0002177_abnormal_outer_ear0.63329153
126MP0009278_abnormal_bone_marrow0.62979316
127MP0002163_abnormal_gland_morphology0.62833557
128MP0002092_abnormal_eye_morphology0.62185292
129MP0001727_abnormal_embryo_implantation0.62007278
130MP0002102_abnormal_ear_morphology0.61180423
131MP0001186_pigmentation_phenotype0.61053195
132MP0001346_abnormal_lacrimal_gland0.59919837
133MP0001919_abnormal_reproductive_system0.58723503
134MP0000015_abnormal_ear_pigmentation0.57481182
135MP0002160_abnormal_reproductive_system0.57215568
136MP0003950_abnormal_plasma_membrane0.57139626
137MP0003303_peritoneal_inflammation0.56215930
138MP0005197_abnormal_uvea_morphology0.54889655
139MP0002234_abnormal_pharynx_morphology0.54821525
140MP0001324_abnormal_eye_pigmentation0.53634983
141MP0005621_abnormal_cell_physiology0.53233998
142MP0005391_vision/eye_phenotype0.53053624
143MP0000579_abnormal_nail_morphology0.53050130
144MP0003699_abnormal_female_reproductive0.53020009
145MP0001881_abnormal_mammary_gland0.52691908
146MP0003755_abnormal_palate_morphology0.51029841
147MP0005330_cardiomyopathy0.50245563
148MP0005084_abnormal_gallbladder_morpholo0.49502955

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.18936573
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.33649509
3Abnormality of cells of the erythroid lineage (HP:0012130)4.24627533
4Abnormal number of erythroid precursors (HP:0012131)4.20218709
5Acute necrotizing encephalopathy (HP:0006965)4.11487112
6Chromsome breakage (HP:0040012)4.09095510
7Abnormal mitochondria in muscle tissue (HP:0008316)3.87209871
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84517381
9Acute encephalopathy (HP:0006846)3.83737508
10Absent/shortened dynein arms (HP:0200106)3.76856441
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.76856441
1211 pairs of ribs (HP:0000878)3.73314146
13Mitochondrial inheritance (HP:0001427)3.53437344
14Increased CSF lactate (HP:0002490)3.43510391
15Hepatocellular necrosis (HP:0001404)3.27769585
16Progressive macrocephaly (HP:0004481)3.25372158
17Pallor (HP:0000980)3.13651425
18Abnormality of the preputium (HP:0100587)3.12443049
19Abnormality of chromosome stability (HP:0003220)3.12316184
20Increased serum pyruvate (HP:0003542)3.02579896
21Lipid accumulation in hepatocytes (HP:0006561)2.98355630
22Abnormality of glycolysis (HP:0004366)2.98170485
23Abnormal spermatogenesis (HP:0008669)2.97337088
24Aplastic anemia (HP:0001915)2.96444878
25Meckel diverticulum (HP:0002245)2.95054802
26Thrombocytosis (HP:0001894)2.94879814
27Hepatic necrosis (HP:0002605)2.93217574
28Cerebral edema (HP:0002181)2.92403033
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90043909
30Small intestinal stenosis (HP:0012848)2.89127207
31Duodenal stenosis (HP:0100867)2.89127207
32Oral leukoplakia (HP:0002745)2.88827577
33Breast hypoplasia (HP:0003187)2.86692001
34Impulsivity (HP:0100710)2.83958109
35Abnormal respiratory epithelium morphology (HP:0012253)2.83724987
36Abnormal respiratory motile cilium morphology (HP:0005938)2.83724987
37Abnormality of the ileum (HP:0001549)2.82784902
38Abnormal lung lobation (HP:0002101)2.80134685
39Birth length less than 3rd percentile (HP:0003561)2.79952043
40Degeneration of anterior horn cells (HP:0002398)2.77251248
41Abnormality of the anterior horn cell (HP:0006802)2.77251248
42Duplicated collecting system (HP:0000081)2.77081800
43Myelodysplasia (HP:0002863)2.76733296
44Macrocytic anemia (HP:0001972)2.76659295
45Nasal polyposis (HP:0100582)2.76218072
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.67316533
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.65524631
48Recurrent abscess formation (HP:0002722)2.64728806
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.62873021
50Renal Fanconi syndrome (HP:0001994)2.61290157
51Abnormal respiratory motile cilium physiology (HP:0012261)2.61058647
52Volvulus (HP:0002580)2.59078546
53Type I transferrin isoform profile (HP:0003642)2.56888783
54Elevated erythrocyte sedimentation rate (HP:0003565)2.56520603
55Recurrent bronchitis (HP:0002837)2.56266277
56Increased serum lactate (HP:0002151)2.56209259
57Absent thumb (HP:0009777)2.53452760
58Abnormality of reticulocytes (HP:0004312)2.52676432
59Carpal bone hypoplasia (HP:0001498)2.50631963
60Sloping forehead (HP:0000340)2.49689785
61Nephroblastoma (Wilms tumor) (HP:0002667)2.48748383
62Cortical dysplasia (HP:0002539)2.47273635
63Reduced antithrombin III activity (HP:0001976)2.42369081
64Recurrent sinusitis (HP:0011108)2.41483924
65Bone marrow hypocellularity (HP:0005528)2.41081887
66Hypoplastic pelvis (HP:0008839)2.41073760
67Abnormality of methionine metabolism (HP:0010901)2.35409610
68Microvesicular hepatic steatosis (HP:0001414)2.32607016
69Obstructive lung disease (HP:0006536)2.32361262
70Chronic obstructive pulmonary disease (HP:0006510)2.32361262
71Colon cancer (HP:0003003)2.31143256
72Abnormality of the renal collecting system (HP:0004742)2.30647552
73Selective tooth agenesis (HP:0001592)2.29421328
74Embryonal renal neoplasm (HP:0011794)2.29174221
75Lactic acidosis (HP:0003128)2.28823857
76Abnormality of the carotid arteries (HP:0005344)2.28132265
77Exercise intolerance (HP:0003546)2.27356429
78Neoplasm of the colon (HP:0100273)2.25661095
79Myositis (HP:0100614)2.24129194
80Recurrent bacterial skin infections (HP:0005406)2.22814371
81Bronchitis (HP:0012387)2.19425831
82Rhinitis (HP:0012384)2.18207194
83Increased intramyocellular lipid droplets (HP:0012240)2.17467404
84Patellar aplasia (HP:0006443)2.16602647
85Abnormality of the labia minora (HP:0012880)2.16132478
86Abnormality of the duodenum (HP:0002246)2.16090129
87Respiratory failure (HP:0002878)2.14249259
88Leukodystrophy (HP:0002415)2.12167029
89Abnormal protein glycosylation (HP:0012346)2.10064776
90Abnormal glycosylation (HP:0012345)2.10064776
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10064776
92Abnormal protein N-linked glycosylation (HP:0012347)2.10064776
93Cleft eyelid (HP:0000625)2.09931643
94Abnormal ciliary motility (HP:0012262)2.09727366
95Facial cleft (HP:0002006)2.07920517
96Abnormality of the nasal mucosa (HP:0000433)2.05764425
97Multiple enchondromatosis (HP:0005701)2.05511897
98Sparse eyelashes (HP:0000653)2.04716967
99Rough bone trabeculation (HP:0100670)2.03982457
100Poikilocytosis (HP:0004447)2.03813460
101Abnormality of the fetal cardiovascular system (HP:0010948)2.03625586
102Abnormal umbilical cord blood vessels (HP:0011403)2.03625586
103Single umbilical artery (HP:0001195)2.03625586
104Abnormality of the umbilical cord (HP:0010881)2.03561293
105Respiratory difficulties (HP:0002880)2.03461018
106Rhabdomyosarcoma (HP:0002859)2.03395107
107Keratoconjunctivitis sicca (HP:0001097)2.03376212
108Clubbing of toes (HP:0100760)2.02641705
109Absent radius (HP:0003974)2.01554256
110Absent epiphyses (HP:0010577)1.99909237
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99909237
112Pancytopenia (HP:0001876)1.99745348
113Retrobulbar optic neuritis (HP:0100654)1.99281731
114Optic neuritis (HP:0100653)1.99281731
115Abnormal auditory evoked potentials (HP:0006958)1.97861493
116Aplasia/Hypoplasia of the patella (HP:0006498)1.97688000
117Exertional dyspnea (HP:0002875)1.96845726
118Poikiloderma (HP:0001029)1.96679756
119Ectopic kidney (HP:0000086)1.94428064
120Cellulitis (HP:0100658)1.93806452
121Tracheoesophageal fistula (HP:0002575)1.92538202
122Increased hepatocellular lipid droplets (HP:0006565)1.92482198
123Ependymoma (HP:0002888)1.91723046
124Proximal placement of thumb (HP:0009623)1.91635813
125Triphalangeal thumb (HP:0001199)1.90345994
126Aplasia involving forearm bones (HP:0009822)1.88935590
127Absent forearm bone (HP:0003953)1.88935590
128Premature graying of hair (HP:0002216)1.88546883
129IgM deficiency (HP:0002850)1.88397325
130High pitched voice (HP:0001620)1.87590535
131Petechiae (HP:0000967)1.85994135
132Pulmonary fibrosis (HP:0002206)1.85498935
133Horseshoe kidney (HP:0000085)1.83775321
134Recurrent otitis media (HP:0000403)1.83587104
135Keratoconjunctivitis (HP:0001096)1.82396351
136Lymphoma (HP:0002665)1.81316456
137Trismus (HP:0000211)1.80700700
138Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80267606
139Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80267606
140Abnormality of B cell number (HP:0010975)1.79761298
141B lymphocytopenia (HP:0010976)1.79761298
142Abnormality of DNA repair (HP:0003254)1.79737327
143Medulloblastoma (HP:0002885)1.79536605
144Bronchiectasis (HP:0002110)1.79168403
145Cafe-au-lait spot (HP:0000957)1.79100944
146Abnormalities of placenta or umbilical cord (HP:0001194)1.78907147
147Agnosia (HP:0010524)1.78824146
148Squamous cell carcinoma (HP:0002860)1.78333842
149Meningitis (HP:0001287)1.76517288
150Abnormality of the prostate (HP:0008775)1.75903087
151Deviation of the thumb (HP:0009603)1.75900153
152Abnormal number of incisors (HP:0011064)1.75664108
153Increased nuchal translucency (HP:0010880)1.75475341
154Megaloblastic anemia (HP:0001889)1.74373343
155Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74206471
156Choanal atresia (HP:0000453)1.72842300
157Adrenal hypoplasia (HP:0000835)1.71789099
158Abnormality of serum amino acid levels (HP:0003112)1.68508332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.53270521
2WEE14.22957300
3EIF2AK14.11989316
4BRSK23.61066391
5VRK23.33759963
6CDC73.30615589
7NEK23.21885792
8BRSK12.62388304
9TESK12.32096314
10TTK2.28773987
11PBK2.09425853
12STK162.03540185
13CCNB12.03479434
14PLK12.01003176
15EIF2AK32.00750620
16AURKB1.91080183
17SRPK11.89156463
18TESK21.88990351
19NME21.88625441
20VRK11.86304394
21NEK11.82740949
22PLK41.76684227
23TRIM281.66825018
24STK41.64158832
25TLK11.62090725
26PDK41.58340523
27PDK31.58340523
28STK101.57440040
29MAP4K11.52189385
30RPS6KA41.48058713
31EIF2AK21.45516191
32MST1R1.42395574
33ACVR1B1.36099446
34PLK31.35940602
35AURKA1.33519327
36ZAK1.32466963
37ATR1.29556077
38TAF11.22102887
39CHEK21.19716042
40MAP3K81.16418604
41CDK71.16125621
42CLK11.12560747
43BLK1.04702099
44MKNK10.96508722
45CHEK10.94370400
46IRAK40.94282111
47CDK40.93683553
48DYRK30.88956319
49PAK40.82167133
50MST40.81893618
51RPS6KB20.79494178
52MAP3K120.79426304
53MAP3K110.79277666
54MARK30.78892459
55PASK0.74641560
56TXK0.73581861
57PIM10.72598268
58PDK20.72318143
59TEC0.72095892
60PIM20.69370958
61ATM0.67462342
62PAK10.66228423
63BTK0.66165245
64KDR0.65598488
65ERBB30.65275820
66LIMK10.64176740
67PLK20.62539881
68EPHA20.61653119
69ERBB40.61460075
70MELK0.59611422
71ZAP700.58839184
72TNIK0.57405111
73CSNK2A10.55672956
74CDK60.54915757
75PNCK0.54255115
76STK30.53098881
77SYK0.52386078
78MET0.52056286
79BRAF0.51862969
80BCR0.51626642
81BMPR1B0.51428318
82MKNK20.51038059
83BCKDK0.50194037
84MAP3K140.46620985
85LRRK20.45848689
86NEK90.45846421
87NUAK10.45409742
88CDK10.45243926
89RPS6KA50.44881118
90LYN0.44800913
91CDK20.44625786
92PRKCI0.43092688
93WNK30.42991385
94NME10.41168515
95ARAF0.41117953
96GRK60.41030513
97CDK120.40336259
98DAPK10.40209822
99CDK80.39398683
100MAPKAPK20.38990821
101CSNK2A20.36954035
102CDK180.36642596
103MINK10.34695284
104UHMK10.33869154
105CDK140.32982396
106SCYL20.32572760
107SIK30.32440080
108KIT0.31403422
109CDK150.30981408
110RPS6KC10.30916685
111RPS6KL10.30916685
112RPS6KA60.30348110
113CDK11A0.29876141
114CSNK1G30.29781910
115MAP2K70.29678934
116ALK0.29162700
117MAP2K30.28471718
118EEF2K0.28280938
119CSNK1G10.27322879
120ABL20.26900509
121STK38L0.26074159
122PTK2B0.24950956
123ILK0.24924024
124CSF1R0.24319314
125MYLK0.23341437
126TBK10.23209563
127IKBKB0.22321202
128TSSK60.21664657
129TRPM70.21451957
130AKT20.21080136
131MAP3K100.20449624
132TGFBR10.19706507
133RIPK40.19307381
134FGFR10.18095810
135DAPK30.15745646
136CSNK1G20.15510935

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.50499374
2Ribosome_Homo sapiens_hsa030104.05979822
3Mismatch repair_Homo sapiens_hsa034303.64751465
4Proteasome_Homo sapiens_hsa030503.45069468
5Homologous recombination_Homo sapiens_hsa034403.15213057
6Base excision repair_Homo sapiens_hsa034103.01118526
7Spliceosome_Homo sapiens_hsa030402.94423204
8Cell cycle_Homo sapiens_hsa041102.93958412
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82469619
10Fanconi anemia pathway_Homo sapiens_hsa034602.62460642
11RNA transport_Homo sapiens_hsa030132.60007358
12Nucleotide excision repair_Homo sapiens_hsa034202.56100078
13RNA polymerase_Homo sapiens_hsa030202.48917130
14Pyrimidine metabolism_Homo sapiens_hsa002402.32236976
15Non-homologous end-joining_Homo sapiens_hsa034502.13034016
16Basal transcription factors_Homo sapiens_hsa030221.98351570
17Systemic lupus erythematosus_Homo sapiens_hsa053221.92464648
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83013101
19p53 signaling pathway_Homo sapiens_hsa041151.79950468
20RNA degradation_Homo sapiens_hsa030181.76579008
21One carbon pool by folate_Homo sapiens_hsa006701.54201397
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48707118
23mRNA surveillance pathway_Homo sapiens_hsa030151.48351813
24Pentose phosphate pathway_Homo sapiens_hsa000301.44715086
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41195108
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38990733
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38331485
28Folate biosynthesis_Homo sapiens_hsa007901.37701570
29Oocyte meiosis_Homo sapiens_hsa041141.33828554
30Huntingtons disease_Homo sapiens_hsa050161.30080574
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29612087
32Purine metabolism_Homo sapiens_hsa002301.29183848
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28041922
34Fatty acid elongation_Homo sapiens_hsa000621.26530498
35Antigen processing and presentation_Homo sapiens_hsa046121.24213095
36Protein export_Homo sapiens_hsa030601.23688828
37Epstein-Barr virus infection_Homo sapiens_hsa051691.20807129
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19253162
39Herpes simplex infection_Homo sapiens_hsa051681.16101811
40Parkinsons disease_Homo sapiens_hsa050121.15179596
41Vitamin B6 metabolism_Homo sapiens_hsa007501.14917056
42Primary immunodeficiency_Homo sapiens_hsa053401.12250931
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08639263
44Propanoate metabolism_Homo sapiens_hsa006401.05103022
45Viral carcinogenesis_Homo sapiens_hsa052031.03201081
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98367571
47Legionellosis_Homo sapiens_hsa051340.92875712
48Oxidative phosphorylation_Homo sapiens_hsa001900.90867515
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86791474
50Steroid biosynthesis_Homo sapiens_hsa001000.84202844
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.78620566
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77715639
53Measles_Homo sapiens_hsa051620.76901339
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74855837
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70574344
56HTLV-I infection_Homo sapiens_hsa051660.70091728
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69725487
58Glutathione metabolism_Homo sapiens_hsa004800.66385069
59Hematopoietic cell lineage_Homo sapiens_hsa046400.66071271
60Apoptosis_Homo sapiens_hsa042100.65879571
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65843830
62Leishmaniasis_Homo sapiens_hsa051400.65498134
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.64173545
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63735770
65Graft-versus-host disease_Homo sapiens_hsa053320.62279654
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61936665
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61905280
68Alcoholism_Homo sapiens_hsa050340.61709390
69Shigellosis_Homo sapiens_hsa051310.61116382
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59910634
71Cardiac muscle contraction_Homo sapiens_hsa042600.59215465
72Asthma_Homo sapiens_hsa053100.57925833
73Small cell lung cancer_Homo sapiens_hsa052220.57239942
74Influenza A_Homo sapiens_hsa051640.56354845
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55398167
76Allograft rejection_Homo sapiens_hsa053300.53593471
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52349441
78Sulfur metabolism_Homo sapiens_hsa009200.51475367
79Alzheimers disease_Homo sapiens_hsa050100.50320881
80Renin-angiotensin system_Homo sapiens_hsa046140.47600033
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47552404
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46949427
83Hepatitis B_Homo sapiens_hsa051610.46948724
84Arachidonic acid metabolism_Homo sapiens_hsa005900.44752429
85Selenocompound metabolism_Homo sapiens_hsa004500.44020975
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42639142
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41939152
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41637993
89Viral myocarditis_Homo sapiens_hsa054160.40567173
90B cell receptor signaling pathway_Homo sapiens_hsa046620.39547168
91Malaria_Homo sapiens_hsa051440.38848928
92Carbon metabolism_Homo sapiens_hsa012000.38630380
93Tyrosine metabolism_Homo sapiens_hsa003500.35981510
94MicroRNAs in cancer_Homo sapiens_hsa052060.35605460
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35166655
96Fatty acid metabolism_Homo sapiens_hsa012120.34293844
97N-Glycan biosynthesis_Homo sapiens_hsa005100.34118542
98Biosynthesis of amino acids_Homo sapiens_hsa012300.33077759
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.33040518
100Arginine and proline metabolism_Homo sapiens_hsa003300.31645774
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.31590301
102Galactose metabolism_Homo sapiens_hsa000520.30853282
103Fructose and mannose metabolism_Homo sapiens_hsa000510.26885986
104Peroxisome_Homo sapiens_hsa041460.26567089
105Sulfur relay system_Homo sapiens_hsa041220.26263798
106Hippo signaling pathway_Homo sapiens_hsa043900.24859886
107TGF-beta signaling pathway_Homo sapiens_hsa043500.24691262
108Pertussis_Homo sapiens_hsa051330.23865158
109Salmonella infection_Homo sapiens_hsa051320.23264183
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.22806592
111Metabolic pathways_Homo sapiens_hsa011000.22742118
112Tuberculosis_Homo sapiens_hsa051520.22323147
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21591278
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.21587487
115Fatty acid degradation_Homo sapiens_hsa000710.21131808
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20765965
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.20662009
118Autoimmune thyroid disease_Homo sapiens_hsa053200.20365835
119Thyroid cancer_Homo sapiens_hsa052160.19481792
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19198074
121Phagosome_Homo sapiens_hsa041450.19166446
122Osteoclast differentiation_Homo sapiens_hsa043800.18377195
123beta-Alanine metabolism_Homo sapiens_hsa004100.18286893
124Pyruvate metabolism_Homo sapiens_hsa006200.17583885
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17506183
126HIF-1 signaling pathway_Homo sapiens_hsa040660.16986931
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16591459
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16185345
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15489939
130Phenylalanine metabolism_Homo sapiens_hsa003600.15142478
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14781858
132Basal cell carcinoma_Homo sapiens_hsa052170.14445128
133Wnt signaling pathway_Homo sapiens_hsa043100.11854398
134Butanoate metabolism_Homo sapiens_hsa006500.10939928
135Lysine degradation_Homo sapiens_hsa003100.07969034
136Adherens junction_Homo sapiens_hsa045200.07847014
137Tryptophan metabolism_Homo sapiens_hsa003800.05520011
138Chemical carcinogenesis_Homo sapiens_hsa052040.04569871
139Colorectal cancer_Homo sapiens_hsa052100.02734218
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.01459871

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