CDKL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.80636491
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.79608018
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.70909529
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.62176884
5locomotory exploration behavior (GO:0035641)5.39390916
6synaptic vesicle exocytosis (GO:0016079)5.25947460
7protein localization to synapse (GO:0035418)5.21521047
8neuron cell-cell adhesion (GO:0007158)5.20650065
9regulation of glutamate receptor signaling pathway (GO:1900449)5.16043320
10glutamate secretion (GO:0014047)5.08781291
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.01856005
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89609875
13synaptic vesicle maturation (GO:0016188)4.89391149
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.81937689
15regulation of synaptic vesicle exocytosis (GO:2000300)4.78642813
16glutamate receptor signaling pathway (GO:0007215)4.70422102
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.70078015
18neuronal action potential propagation (GO:0019227)4.59512502
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.55424822
20exploration behavior (GO:0035640)4.46403712
21synaptic transmission, glutamatergic (GO:0035249)4.41878503
22neuron-neuron synaptic transmission (GO:0007270)4.39098478
23behavioral response to nicotine (GO:0035095)4.32782250
24presynaptic membrane assembly (GO:0097105)4.32108775
25regulation of synaptic vesicle transport (GO:1902803)4.28126178
26neurotransmitter-gated ion channel clustering (GO:0072578)4.25667170
27regulation of neuronal synaptic plasticity (GO:0048168)4.24296137
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.15353394
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.13951030
30dendritic spine morphogenesis (GO:0060997)4.10864957
31postsynaptic membrane organization (GO:0001941)4.07203694
32neuron recognition (GO:0008038)4.00829444
33neurotransmitter secretion (GO:0007269)4.00220949
34long-term memory (GO:0007616)3.96763742
35regulation of postsynaptic membrane potential (GO:0060078)3.95494204
36long-term synaptic potentiation (GO:0060291)3.93084835
37presynaptic membrane organization (GO:0097090)3.90645037
38positive regulation of membrane potential (GO:0045838)3.90317328
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.86102483
40regulation of dendritic spine morphogenesis (GO:0061001)3.85352552
41regulation of synapse structural plasticity (GO:0051823)3.83400818
42layer formation in cerebral cortex (GO:0021819)3.80987675
43positive regulation of synapse maturation (GO:0090129)3.78724603
44regulation of synaptic plasticity (GO:0048167)3.76484287
45gamma-aminobutyric acid transport (GO:0015812)3.71363396
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.68858340
47response to histamine (GO:0034776)3.67406054
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66705321
49axonal fasciculation (GO:0007413)3.65704322
50serotonin metabolic process (GO:0042428)3.64652282
51membrane depolarization during action potential (GO:0086010)3.61423568
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.60103760
53positive regulation of neurotransmitter secretion (GO:0001956)3.54920438
54neuronal action potential (GO:0019228)3.52396371
55primary amino compound metabolic process (GO:1901160)3.50159101
56regulation of dendritic spine development (GO:0060998)3.48485924
57transmission of nerve impulse (GO:0019226)3.48264880
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44508785
59synaptic vesicle endocytosis (GO:0048488)3.42023652
60behavioral defense response (GO:0002209)3.39140482
61behavioral fear response (GO:0001662)3.39140482
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.37946764
63regulation of neurotransmitter secretion (GO:0046928)3.37764698
64behavioral response to cocaine (GO:0048148)3.36628794
65startle response (GO:0001964)3.34624488
66cellular potassium ion homeostasis (GO:0030007)3.34191764
67cerebellar granule cell differentiation (GO:0021707)3.32641783
68neurotransmitter transport (GO:0006836)3.32545505
69auditory behavior (GO:0031223)3.29474813
70proline transport (GO:0015824)3.29162370
71membrane depolarization (GO:0051899)3.24696077
72learning (GO:0007612)3.23360544
73fear response (GO:0042596)3.23047892
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.22526240
75synapse assembly (GO:0007416)3.20766680
76regulation of vesicle fusion (GO:0031338)3.20671773
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18700324
78cerebellar Purkinje cell differentiation (GO:0021702)3.18656384
79dendritic spine organization (GO:0097061)3.18382260
80positive regulation of neurotransmitter transport (GO:0051590)3.18319174
81negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17600574
82positive regulation of dendritic spine development (GO:0060999)3.15128412
83long term synaptic depression (GO:0060292)3.14826106
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13745451
85detection of light stimulus involved in sensory perception (GO:0050962)3.11414770
86detection of light stimulus involved in visual perception (GO:0050908)3.11414770
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10712996
88regulation of hippo signaling (GO:0035330)3.10679367
89regulation of synapse maturation (GO:0090128)3.10364266
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08369776
91positive regulation of dendritic spine morphogenesis (GO:0061003)3.08246932
92mechanosensory behavior (GO:0007638)3.08144861
93innervation (GO:0060384)3.07609097
94regulation of neurotransmitter transport (GO:0051588)3.06537381
95membrane hyperpolarization (GO:0060081)3.05544286
96positive regulation of synaptic transmission (GO:0050806)3.04459331
97central nervous system projection neuron axonogenesis (GO:0021952)3.04058477
98response to auditory stimulus (GO:0010996)3.03567914
99regulation of glutamate secretion (GO:0014048)3.02755887
100L-fucose catabolic process (GO:0042355)3.02560131
101fucose catabolic process (GO:0019317)3.02560131
102L-fucose metabolic process (GO:0042354)3.02560131
103regulation of neurotransmitter levels (GO:0001505)3.02494090
104regulation of synaptic transmission (GO:0050804)3.00650608
105social behavior (GO:0035176)3.00504396
106intraspecies interaction between organisms (GO:0051703)3.00504396
107regulation of translation, ncRNA-mediated (GO:0045974)3.00294647
108negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00294647
109negative regulation of translation, ncRNA-mediated (GO:0040033)3.00294647
110neuromuscular process controlling balance (GO:0050885)2.98618331
111detection of calcium ion (GO:0005513)2.98436173
112regulation of voltage-gated calcium channel activity (GO:1901385)2.97769979
113synaptic transmission (GO:0007268)2.96730684
114cochlea development (GO:0090102)2.96726700
115dendrite morphogenesis (GO:0048813)2.95876312
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95792017
117indole-containing compound metabolic process (GO:0042430)2.91270184
118behavioral response to ethanol (GO:0048149)2.89956142
119atrial cardiac muscle cell action potential (GO:0086014)2.89171189
120tryptophan catabolic process (GO:0006569)2.87428049
121indole-containing compound catabolic process (GO:0042436)2.87428049
122indolalkylamine catabolic process (GO:0046218)2.87428049
123action potential (GO:0001508)2.86469942
124regulation of action potential (GO:0098900)2.84775990
125kynurenine metabolic process (GO:0070189)2.83440072
126positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.83136017
127reflex (GO:0060004)2.80474001
128retinal cone cell development (GO:0046549)2.73494635
129positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.72987212
130urinary tract smooth muscle contraction (GO:0014848)2.72843256
131indolalkylamine metabolic process (GO:0006586)2.69538646
132cAMP catabolic process (GO:0006198)2.68933228
133regulation of neurotransmitter uptake (GO:0051580)2.68170471
134detection of mechanical stimulus involved in sensory perception (GO:0050974)2.66534337
135regulation of gene silencing by RNA (GO:0060966)2.66207682
136regulation of posttranscriptional gene silencing (GO:0060147)2.66207682
137regulation of gene silencing by miRNA (GO:0060964)2.66207682
138axon ensheathment in central nervous system (GO:0032291)2.65615272
139central nervous system myelination (GO:0022010)2.65615272
140peristalsis (GO:0030432)2.65491034
141regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62965103
142potassium ion transmembrane transport (GO:0071805)2.61775878
143cellular potassium ion transport (GO:0071804)2.61775878
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61749387
145adult walking behavior (GO:0007628)2.60760113
146positive regulation of sodium ion transmembrane transport (GO:1902307)2.59157961
147cyclic nucleotide catabolic process (GO:0009214)2.58125836
148neuromuscular synaptic transmission (GO:0007274)2.57110102
149C4-dicarboxylate transport (GO:0015740)2.57075518
150multicellular organismal signaling (GO:0035637)2.57045953
151regulation of calcium ion-dependent exocytosis (GO:0017158)2.56204454
152inner ear receptor stereocilium organization (GO:0060122)2.53293762
153auditory receptor cell stereocilium organization (GO:0060088)2.52796443
154sulfation (GO:0051923)2.50876833
155central nervous system neuron axonogenesis (GO:0021955)2.49042790
156potassium ion transport (GO:0006813)2.47391138
157neural tube formation (GO:0001841)2.46989188
158kidney morphogenesis (GO:0060993)2.46897568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94199149
2GBX2_23144817_ChIP-Seq_PC3_Human4.12474909
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07266532
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04038217
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94502295
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59599821
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56926990
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56926990
9REST_21632747_ChIP-Seq_MESCs_Mouse2.47096915
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45043396
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43689465
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.42090535
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38758587
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34915364
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31450607
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.27529579
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.25819262
18TAF15_26573619_Chip-Seq_HEK293_Human2.20505193
19DROSHA_22980978_ChIP-Seq_HELA_Human2.20189519
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09472478
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.08879755
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06827974
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06157449
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.05674979
25AR_21572438_ChIP-Seq_LNCaP_Human2.03301658
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96719865
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96571305
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92657195
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87932309
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.87887009
31SMAD4_21799915_ChIP-Seq_A2780_Human1.84773591
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74177588
33P300_19829295_ChIP-Seq_ESCs_Human1.71099735
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.68454232
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67675580
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64192104
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63174553
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.59012655
39EWS_26573619_Chip-Seq_HEK293_Human1.57737343
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54048428
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.53597124
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53141824
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53116523
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51581516
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47257110
46FUS_26573619_Chip-Seq_HEK293_Human1.46309528
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45678757
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.45656342
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.44939221
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.41818104
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40570175
52AR_25329375_ChIP-Seq_VCAP_Human1.37715270
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37553829
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.36743874
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36572118
56STAT3_23295773_ChIP-Seq_U87_Human1.35730232
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34899836
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34462518
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34422885
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34406049
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33095304
62IGF1R_20145208_ChIP-Seq_DFB_Human1.32605408
63ZNF274_21170338_ChIP-Seq_K562_Hela1.29934549
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29387225
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28616638
66CBP_20019798_ChIP-Seq_JUKART_Human1.28616638
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27028364
68VDR_22108803_ChIP-Seq_LS180_Human1.24447473
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23770585
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23549161
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23532328
72TP53_16413492_ChIP-PET_HCT116_Human1.23267761
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.22990667
74TCF4_23295773_ChIP-Seq_U87_Human1.22516312
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.21531159
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21316245
77TCF4_22108803_ChIP-Seq_LS180_Human1.20486290
78RNF2_27304074_Chip-Seq_NSC_Mouse1.19452474
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.19281767
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17793309
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17524390
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16871432
83AHR_22903824_ChIP-Seq_MCF-7_Human1.16522297
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.16170242
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.16022921
86AR_19668381_ChIP-Seq_PC3_Human1.16001630
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14568203
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14291372
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.13407177
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.11665841
91KDM2B_26808549_Chip-Seq_REH_Human1.10904570
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.10531252
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09807126
94RXR_22108803_ChIP-Seq_LS180_Human1.09048724
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08983015
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08983015
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08163981
98ER_23166858_ChIP-Seq_MCF-7_Human1.07960578
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07932407
100TP53_18474530_ChIP-ChIP_U2OS_Human1.07749316
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07460829
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06731032
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.05092702
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04870908
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04480117
106SMAD3_21741376_ChIP-Seq_ESCs_Human1.03538522
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03535200
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.02323309
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01980594
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01808675
111NANOG_19829295_ChIP-Seq_ESCs_Human1.01462956
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01147565
113JUN_21703547_ChIP-Seq_K562_Human1.00898551
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.00372359
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00350518
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99846587
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95816727
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95555369
119BCAT_22108803_ChIP-Seq_LS180_Human0.95488271
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94604060
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.93915862
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92671460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.54201447
2MP0003880_abnormal_central_pattern5.45488466
3MP0003635_abnormal_synaptic_transmissio4.25803789
4MP0004270_analgesia3.83623286
5MP0009745_abnormal_behavioral_response3.60188590
6MP0002063_abnormal_learning/memory/cond3.48501376
7MP0002064_seizures3.19246251
8MP0001968_abnormal_touch/_nociception3.09975924
9MP0009046_muscle_twitch3.06034750
10MP0002572_abnormal_emotion/affect_behav2.97967604
11MP0001486_abnormal_startle_reflex2.70132391
12MP0002822_catalepsy2.65734302
13MP0002272_abnormal_nervous_system2.63300941
14MP0002734_abnormal_mechanical_nocicepti2.55630433
15MP0008877_abnormal_DNA_methylation2.42588157
16MP0005423_abnormal_somatic_nervous2.38830469
17MP0002736_abnormal_nociception_after2.33799127
18MP0001501_abnormal_sleep_pattern2.33796932
19MP0002735_abnormal_chemical_nociception2.23330382
20MP0001440_abnormal_grooming_behavior2.17675839
21MP0009780_abnormal_chondrocyte_physiolo2.12353870
22MP0002067_abnormal_sensory_capabilities2.06373544
23MP0000778_abnormal_nervous_system1.99245241
24MP0003195_calcinosis1.89123456
25MP0002733_abnormal_thermal_nociception1.87366726
26MP0001970_abnormal_pain_threshold1.84503274
27MP0004924_abnormal_behavior1.82849228
28MP0005386_behavior/neurological_phenoty1.82849228
29MP0002557_abnormal_social/conspecific_i1.81719765
30MP0002184_abnormal_innervation1.81670723
31MP0001984_abnormal_olfaction1.81276743
32MP0001188_hyperpigmentation1.79773531
33MP0004043_abnormal_pH_regulation1.78689006
34MP0005646_abnormal_pituitary_gland1.75167133
35MP0003329_amyloid_beta_deposits1.72466165
36MP0003646_muscle_fatigue1.68706181
37MP0008569_lethality_at_weaning1.68331506
38MP0003879_abnormal_hair_cell1.66425599
39MP0004147_increased_porphyrin_level1.65044374
40MP0004811_abnormal_neuron_physiology1.62350876
41MP0006276_abnormal_autonomic_nervous1.55196934
42MP0001529_abnormal_vocalization1.54444366
43MP0001986_abnormal_taste_sensitivity1.53664889
44MP0003787_abnormal_imprinting1.53457413
45MP0002909_abnormal_adrenal_gland1.44771958
46MP0000955_abnormal_spinal_cord1.43846950
47MP0000427_abnormal_hair_cycle1.39245370
48MP0002066_abnormal_motor_capabilities/c1.39207441
49MP0002882_abnormal_neuron_morphology1.39119577
50MP0003890_abnormal_embryonic-extraembry1.36046876
51MP0001905_abnormal_dopamine_level1.31117559
52MP0003633_abnormal_nervous_system1.31016288
53MP0004885_abnormal_endolymph1.27887157
54MP0004858_abnormal_nervous_system1.27818759
55MP0001502_abnormal_circadian_rhythm1.23547710
56MP0005645_abnormal_hypothalamus_physiol1.19258225
57MP0004133_heterotaxia1.17088975
58MP0005174_abnormal_tail_pigmentation1.16140792
59MP0005409_darkened_coat_color1.14369870
60MP0005253_abnormal_eye_physiology1.14107905
61MP0003631_nervous_system_phenotype1.12880744
62MP0002152_abnormal_brain_morphology1.10664703
63MP0005551_abnormal_eye_electrophysiolog1.09125538
64MP0004742_abnormal_vestibular_system1.08401050
65MP0003136_yellow_coat_color1.06498013
66MP0004145_abnormal_muscle_electrophysio1.05009745
67MP0004142_abnormal_muscle_tone1.03650243
68MP0004130_abnormal_muscle_cell1.03332916
69MP0010386_abnormal_urinary_bladder1.02918719
70MP0000569_abnormal_digit_pigmentation0.99541607
71MP0003119_abnormal_digestive_system0.99296879
72MP0002837_dystrophic_cardiac_calcinosis0.95714892
73MP0008874_decreased_physiological_sensi0.94921871
74MP0001963_abnormal_hearing_physiology0.93169372
75MP0008872_abnormal_physiological_respon0.92172524
76MP0002928_abnormal_bile_duct0.91953773
77MP0002876_abnormal_thyroid_physiology0.91613722
78MP0002229_neurodegeneration0.91235691
79MP0000383_abnormal_hair_follicle0.91225662
80MP0006072_abnormal_retinal_apoptosis0.89210221
81MP0001177_atelectasis0.88677463
82MP0002234_abnormal_pharynx_morphology0.88592245
83MP0003121_genomic_imprinting0.87639632
84MP0002069_abnormal_eating/drinking_beha0.86883380
85MP0002653_abnormal_ependyma_morphology0.86313718
86MP0004085_abnormal_heartbeat0.85659314
87MP0000631_abnormal_neuroendocrine_gland0.84788714
88MP0004484_altered_response_of0.84296051
89MP0005167_abnormal_blood-brain_barrier0.81731286
90MP0005499_abnormal_olfactory_system0.81165156
91MP0005394_taste/olfaction_phenotype0.81165156
92MP0002938_white_spotting0.80936853
93MP0000230_abnormal_systemic_arterial0.80715364
94MP0002160_abnormal_reproductive_system0.80316816
95MP0003122_maternal_imprinting0.79540946
96MP0003283_abnormal_digestive_organ0.78503505
97MP0002752_abnormal_somatic_nervous0.77071256
98MP0003632_abnormal_nervous_system0.76672445
99MP0005187_abnormal_penis_morphology0.76483411
100MP0003878_abnormal_ear_physiology0.75382612
101MP0005377_hearing/vestibular/ear_phenot0.75382612
102MP0005195_abnormal_posterior_eye0.75148205
103MP0005171_absent_coat_pigmentation0.75093561
104MP0001485_abnormal_pinna_reflex0.74996191
105MP0008875_abnormal_xenobiotic_pharmacok0.74977438
106MP0000920_abnormal_myelination0.74297874
107MP0004215_abnormal_myocardial_fiber0.74155589
108MP0000751_myopathy0.73638823
109MP0005535_abnormal_body_temperature0.73033682
110MP0002751_abnormal_autonomic_nervous0.69712704
111MP0000604_amyloidosis0.69603216
112MP0003634_abnormal_glial_cell0.68028880
113MP0001664_abnormal_digestion0.67015696
114MP0000013_abnormal_adipose_tissue0.66025003
115MP0006292_abnormal_olfactory_placode0.64311846
116MP0002090_abnormal_vision0.62457830
117MP0003075_altered_response_to0.62428729
118MP0004510_myositis0.60657337
119MP0000026_abnormal_inner_ear0.60213545
120MP0003690_abnormal_glial_cell0.59098969
121MP0003861_abnormal_nervous_system0.56605786
122MP0002102_abnormal_ear_morphology0.56245195
123MP0003137_abnormal_impulse_conducting0.55708745
124MP0001943_abnormal_respiration0.54031136
125MP0004233_abnormal_muscle_weight0.51651071
126MP0005623_abnormal_meninges_morphology0.51479378
127MP0002638_abnormal_pupillary_reflex0.50538708
128MP0010770_preweaning_lethality0.50022879
129MP0002082_postnatal_lethality0.50022879
130MP0010769_abnormal_survival0.49649321

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.39925022
2Focal seizures (HP:0007359)6.32752907
3Myokymia (HP:0002411)6.17257306
4Epileptic encephalopathy (HP:0200134)6.05440064
5Febrile seizures (HP:0002373)5.15949332
6Atonic seizures (HP:0010819)5.10468797
7Visual hallucinations (HP:0002367)5.09375176
8Absence seizures (HP:0002121)4.72383551
9Dialeptic seizures (HP:0011146)4.39909191
10Progressive cerebellar ataxia (HP:0002073)4.29541987
11Generalized tonic-clonic seizures (HP:0002069)4.26935670
12Pancreatic cysts (HP:0001737)3.94712916
13Gaze-evoked nystagmus (HP:0000640)3.83675911
14* Broad-based gait (HP:0002136)3.83204693
15Pancreatic fibrosis (HP:0100732)3.59965106
16* Hyperventilation (HP:0002883)3.42570713
17Amblyopia (HP:0000646)3.40361262
18Molar tooth sign on MRI (HP:0002419)3.39175080
19Abnormality of midbrain morphology (HP:0002418)3.39175080
20Congenital stationary night blindness (HP:0007642)3.36693986
21True hermaphroditism (HP:0010459)3.32828341
22Action tremor (HP:0002345)3.32543485
23Dysdiadochokinesis (HP:0002075)3.29394104
24Supranuclear gaze palsy (HP:0000605)3.26751229
25Nephronophthisis (HP:0000090)3.22210628
26* Poor eye contact (HP:0000817)3.22009299
27Impaired vibration sensation in the lower limbs (HP:0002166)3.21194378
28Dysmetria (HP:0001310)3.17166194
29Truncal ataxia (HP:0002078)3.10086849
30Urinary bladder sphincter dysfunction (HP:0002839)3.08246985
31Cerebral inclusion bodies (HP:0100314)3.07822566
32Progressive inability to walk (HP:0002505)3.00093723
33* Excessive salivation (HP:0003781)2.95049764
34* Drooling (HP:0002307)2.95049764
35Anxiety (HP:0000739)2.89450189
36Mutism (HP:0002300)2.89294605
37Neurofibrillary tangles (HP:0002185)2.88808373
38Scanning speech (HP:0002168)2.87765482
39Birth length less than 3rd percentile (HP:0003561)2.86941566
40Abnormality of the renal medulla (HP:0100957)2.85922241
41Depression (HP:0000716)2.84552617
42* Impaired social interactions (HP:0000735)2.82952120
43* Abnormal social behavior (HP:0012433)2.82952120
44Type II lissencephaly (HP:0007260)2.81269752
45Genetic anticipation (HP:0003743)2.80939643
46Abnormality of the renal cortex (HP:0011035)2.78202657
47Impaired smooth pursuit (HP:0007772)2.73329429
48Ankle clonus (HP:0011448)2.72690312
49Papilledema (HP:0001085)2.63936178
50Hemiparesis (HP:0001269)2.63462028
51Abnormality of binocular vision (HP:0011514)2.63312239
52Diplopia (HP:0000651)2.63312239
53* Epileptiform EEG discharges (HP:0011182)2.63177647
54Cystic liver disease (HP:0006706)2.59374049
55Abnormal eating behavior (HP:0100738)2.59088723
56Fetal akinesia sequence (HP:0001989)2.57645361
57Attenuation of retinal blood vessels (HP:0007843)2.57627628
58Tubular atrophy (HP:0000092)2.56975472
59Postural instability (HP:0002172)2.55894547
60Termporal pattern (HP:0011008)2.53833023
61Insidious onset (HP:0003587)2.53833023
62Abnormality of the corticospinal tract (HP:0002492)2.53509415
63Abnormal drinking behavior (HP:0030082)2.53384289
64Polydipsia (HP:0001959)2.53384289
65Chronic hepatic failure (HP:0100626)2.47705118
66* Stereotypic behavior (HP:0000733)2.46529363
67Urinary urgency (HP:0000012)2.42421305
68* Absent speech (HP:0001344)2.41183233
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.36784413
70Spastic gait (HP:0002064)2.36692856
71* Inability to walk (HP:0002540)2.35827961
72* EEG with generalized epileptiform discharges (HP:0011198)2.35680523
73Status epilepticus (HP:0002133)2.34357127
74Torticollis (HP:0000473)2.33016009
75Abolished electroretinogram (ERG) (HP:0000550)2.32080564
76Intention tremor (HP:0002080)2.30656800
77Lissencephaly (HP:0001339)2.29409956
78Abnormality of ocular smooth pursuit (HP:0000617)2.28429645
79Dysmetric saccades (HP:0000641)2.27489916
80Genital tract atresia (HP:0001827)2.25197632
81Impaired vibratory sensation (HP:0002495)2.24913996
82Decreased circulating renin level (HP:0003351)2.24226436
83Increased corneal curvature (HP:0100692)2.23990276
84Keratoconus (HP:0000563)2.23990276
85Bradykinesia (HP:0002067)2.23155229
86Optic nerve hypoplasia (HP:0000609)2.21214205
87Gait imbalance (HP:0002141)2.18601470
88Vaginal atresia (HP:0000148)2.17466244
89Decreased central vision (HP:0007663)2.17458476
90Focal dystonia (HP:0004373)2.17040658
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14583137
92Thickened helices (HP:0000391)2.14035955
93Hyperalaninemia (HP:0003348)2.12959936
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12959936
95Abnormality of alanine metabolism (HP:0010916)2.12959936
96Patellar aplasia (HP:0006443)2.12948238
97* Hypsarrhythmia (HP:0002521)2.08729430
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07813712
99Furrowed tongue (HP:0000221)2.06355480
100Obstructive sleep apnea (HP:0002870)2.06118984
101* Abnormality of salivation (HP:0100755)2.05857904
102Degeneration of the lateral corticospinal tracts (HP:0002314)2.05795921
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05795921
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.03635154
105Absent/shortened dynein arms (HP:0200106)2.03635154
106Stomach cancer (HP:0012126)2.02924037
107Lower limb muscle weakness (HP:0007340)2.02432133
108Polyphagia (HP:0002591)2.02144393
109Megalencephaly (HP:0001355)2.02135386
110Pendular nystagmus (HP:0012043)2.01283428
111Large for gestational age (HP:0001520)1.99389943
112Nephrogenic diabetes insipidus (HP:0009806)1.98407905
113Chorioretinal atrophy (HP:0000533)1.98393567
114Incomplete penetrance (HP:0003829)1.98261885
115Aplasia/Hypoplasia of the patella (HP:0006498)1.97219767
116Prolonged QT interval (HP:0001657)1.97084115
117Lower limb amyotrophy (HP:0007210)1.95008593
118Cerebellar dysplasia (HP:0007033)1.93206863
119Poor coordination (HP:0002370)1.91247304
120Amyotrophic lateral sclerosis (HP:0007354)1.91157582
121* Generalized myoclonic seizures (HP:0002123)1.90461237
122Sclerocornea (HP:0000647)1.90405946
123Polyuria (HP:0000103)1.89183912
124Hypoplastic labia majora (HP:0000059)1.88823953
125Hyperthyroidism (HP:0000836)1.87760125
126Craniofacial dystonia (HP:0012179)1.87553915
127Abnormality of the labia minora (HP:0012880)1.85623775
128Congenital hepatic fibrosis (HP:0002612)1.84742643
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.83422969
130Limb dystonia (HP:0002451)1.83046154
131Abnormality of the lower motor neuron (HP:0002366)1.81658209
132Oligodactyly (hands) (HP:0001180)1.81321092
133Congenital sensorineural hearing impairment (HP:0008527)1.79984813
134Aqueductal stenosis (HP:0002410)1.79525398
135Hemiplegia (HP:0002301)1.79484362
136* Protruding tongue (HP:0010808)1.77913400
137Akinesia (HP:0002304)1.77858910
138Bulbous nose (HP:0000414)1.77632369
139Long nose (HP:0003189)1.77602846
140Abnormality of the pubic bones (HP:0003172)1.76771442
141Delusions (HP:0000746)1.76173548
142Psychosis (HP:0000709)1.75387876
143Specific learning disability (HP:0001328)1.75270889
144Syncope (HP:0001279)1.74945083
145* Gait ataxia (HP:0002066)1.74714464
146Bony spicule pigmentary retinopathy (HP:0007737)1.73514859
147Abnormality of the labia majora (HP:0012881)1.73497626
148Partial agenesis of the corpus callosum (HP:0001338)1.73483856
149Retinal dysplasia (HP:0007973)1.73267113
150Anencephaly (HP:0002323)1.72985701
151Agitation (HP:0000713)1.72921413
152Hypoplastic ischia (HP:0003175)1.72896838
153Pachygyria (HP:0001302)1.72356597
154Abnormality of the ischium (HP:0003174)1.72240754
155* Blue irides (HP:0000635)1.72195561
156Congenital primary aphakia (HP:0007707)1.70103305
157Medial flaring of the eyebrow (HP:0010747)1.68815388
158Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67022656
159Dyskinesia (HP:0100660)1.66965867
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66858417
161Pheochromocytoma (HP:0002666)1.65386234
162Lower limb asymmetry (HP:0100559)1.60608130
163Sleep apnea (HP:0010535)1.58744511
164* Deeply set eye (HP:0000490)1.58399487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.99566497
2EPHA45.08165191
3NTRK34.46090523
4MAP3K93.36959516
5MAP3K43.06670361
6MARK13.04773091
7CASK3.03797952
8BMPR1B3.01809650
9ACVR1B2.91750527
10MAP2K72.86133664
11RIPK42.79403290
12DAPK22.54740028
13MINK12.33618557
14ADRBK22.32131007
15MAP3K122.18722483
16PLK21.97980525
17INSRR1.91499593
18MAP2K41.90493619
19GRK11.88030391
20PAK61.84471060
21DAPK11.80410352
22NTRK21.77349261
23TNIK1.73082623
24WNK41.70608395
25CDK191.70209848
26PNCK1.65801554
27KSR21.65291244
28KSR11.59964810
29BMPR21.53629935
30NTRK11.52309355
31MAP4K21.49899478
32SIK21.49536939
33CAMKK11.47877762
34ZAK1.47759503
35CDK51.45784394
36PRPF4B1.44500848
37MAPK131.33132544
38CAMKK21.28183662
39GRK51.28087711
40TLK11.26859609
41PRKD31.26792338
42STK391.25908930
43CAMK1D1.24628994
44MAP3K131.22778825
45FES1.21213580
46TAOK31.19174275
47MKNK21.18962430
48PRKCG1.16449098
49PIK3CA1.14314169
50CAMK2A1.13330635
51OXSR11.12578767
52CCNB11.11321406
53STK38L1.08503753
54NUAK11.07751417
55ADRBK11.06607808
56ARAF1.03378047
57PTK2B1.00322864
58CAMK2B0.97081503
59MAP3K20.95997587
60STK380.90582942
61WNK10.89103546
62CAMK10.88051073
63TGFBR10.85540232
64RAF10.82353723
65SGK4940.81845020
66SGK2230.81845020
67STK110.80553441
68SGK10.77550547
69AKT30.77336297
70CDK180.76698108
71UHMK10.76557361
72FGR0.76225752
73CDK140.75380088
74SGK20.74319596
75CDK150.73104109
76DYRK1A0.71560736
77LATS20.70287972
78PHKG10.67753651
79PHKG20.67753651
80TYRO30.67691999
81PRKCE0.67233518
82PAK30.66692663
83CAMK40.64743996
84TAOK10.63233592
85CDK11A0.62709006
86CSNK1G20.62252426
87SIK30.58698196
88MUSK0.58395187
89PDPK10.58217527
90MAP3K60.57427822
91PDK10.56979242
92RET0.56718173
93NME10.56561591
94NEK60.56420823
95MARK20.55187571
96DYRK20.53220442
97CAMK1G0.52545315
98CAMK2D0.52308196
99TNK20.51243592
100SGK30.51228491
101FER0.51022822
102MAPK150.50176986
103TIE10.49801357
104MAPKAPK50.49331381
105MAPK120.48344098
106PRKCZ0.47847219
107PRKCH0.47106960
108BCR0.46333211
109PKN10.44879946
110DMPK0.44747416
111MAP2K60.44470507
112CSNK1D0.43501011
113CSNK1A1L0.43340702
114MAP3K10.43088955
115FYN0.42692463
116WNK30.41432805
117PRKAA20.41103481
118PRKACA0.40283950
119PRKAA10.40099730
120PRKG10.39861290
121PINK10.39611672
122CAMK2G0.39316546
123RPS6KA30.39279663
124ERBB30.39243814
125CSNK1G10.39164931
126CSNK1A10.39006576
127LATS10.38933652
128FGFR20.38019037
129BRAF0.37250991
130TXK0.37121031
131MAP3K70.37035230
132MAPK100.36939516
133OBSCN0.36297421
134ERBB20.35053570
135STK30.34809803
136PRKCA0.34785365
137MAPK70.33276591
138PRKCQ0.32634761
139MAP2K10.32422237
140DAPK30.32022257
141NLK0.31908042
142ROCK20.31448772
143PRKACB0.29174986
144TRPM70.27683601
145TRIM280.27603260

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08882441
2Synaptic vesicle cycle_Homo sapiens_hsa047213.00593159
3Long-term potentiation_Homo sapiens_hsa047202.93573345
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90533877
5Circadian entrainment_Homo sapiens_hsa047132.78547836
6Glutamatergic synapse_Homo sapiens_hsa047242.73074849
7GABAergic synapse_Homo sapiens_hsa047272.66060404
8Morphine addiction_Homo sapiens_hsa050322.65445985
9Olfactory transduction_Homo sapiens_hsa047402.63348221
10Amphetamine addiction_Homo sapiens_hsa050312.60120057
11Salivary secretion_Homo sapiens_hsa049702.29676305
12Dopaminergic synapse_Homo sapiens_hsa047282.20684691
13Nitrogen metabolism_Homo sapiens_hsa009101.98026498
14Linoleic acid metabolism_Homo sapiens_hsa005911.97153551
15Renin secretion_Homo sapiens_hsa049241.96412562
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94582622
17Taste transduction_Homo sapiens_hsa047421.91528365
18Insulin secretion_Homo sapiens_hsa049111.91215795
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88628934
20Long-term depression_Homo sapiens_hsa047301.88577839
21Cholinergic synapse_Homo sapiens_hsa047251.87853699
22Serotonergic synapse_Homo sapiens_hsa047261.87423119
23Gastric acid secretion_Homo sapiens_hsa049711.84568444
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81842524
25Oxytocin signaling pathway_Homo sapiens_hsa049211.76290386
26Butanoate metabolism_Homo sapiens_hsa006501.72484200
27Calcium signaling pathway_Homo sapiens_hsa040201.69590648
28Ether lipid metabolism_Homo sapiens_hsa005651.66561724
29Collecting duct acid secretion_Homo sapiens_hsa049661.64622218
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56224921
31Cocaine addiction_Homo sapiens_hsa050301.56117183
32GnRH signaling pathway_Homo sapiens_hsa049121.44169955
33Selenocompound metabolism_Homo sapiens_hsa004501.40014907
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.38431205
35Gap junction_Homo sapiens_hsa045401.34761424
36ABC transporters_Homo sapiens_hsa020101.32019327
37cAMP signaling pathway_Homo sapiens_hsa040241.31087031
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30373338
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29467838
40Axon guidance_Homo sapiens_hsa043601.25765272
41Phototransduction_Homo sapiens_hsa047441.25063175
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22791741
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17360089
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16133962
45Estrogen signaling pathway_Homo sapiens_hsa049151.14040600
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13550797
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12726596
48Tryptophan metabolism_Homo sapiens_hsa003801.11464843
49Glioma_Homo sapiens_hsa052141.11033436
50ErbB signaling pathway_Homo sapiens_hsa040121.08323785
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08024629
52Type II diabetes mellitus_Homo sapiens_hsa049301.07885752
53Melanogenesis_Homo sapiens_hsa049161.07323586
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.01473402
55Vibrio cholerae infection_Homo sapiens_hsa051100.94592212
56Cardiac muscle contraction_Homo sapiens_hsa042600.89038038
57Histidine metabolism_Homo sapiens_hsa003400.86934531
58Caffeine metabolism_Homo sapiens_hsa002320.86372389
59Pancreatic secretion_Homo sapiens_hsa049720.85989328
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84724863
61Dorso-ventral axis formation_Homo sapiens_hsa043200.82944378
62Oocyte meiosis_Homo sapiens_hsa041140.82276622
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81262985
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.79730031
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78222380
66Choline metabolism in cancer_Homo sapiens_hsa052310.76173387
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74554161
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.74461215
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74108871
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.74035510
71MAPK signaling pathway_Homo sapiens_hsa040100.73757507
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73641567
73Glycerolipid metabolism_Homo sapiens_hsa005610.71579689
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70959193
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70165265
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69105133
77Dilated cardiomyopathy_Homo sapiens_hsa054140.68763925
78Fatty acid biosynthesis_Homo sapiens_hsa000610.67147238
79Ras signaling pathway_Homo sapiens_hsa040140.66936503
80Thyroid hormone synthesis_Homo sapiens_hsa049180.66411761
81Mineral absorption_Homo sapiens_hsa049780.65986099
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65869524
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65237480
84African trypanosomiasis_Homo sapiens_hsa051430.65209487
85VEGF signaling pathway_Homo sapiens_hsa043700.63401887
86Regulation of autophagy_Homo sapiens_hsa041400.62528890
87beta-Alanine metabolism_Homo sapiens_hsa004100.60559802
88Rap1 signaling pathway_Homo sapiens_hsa040150.56944427
89Circadian rhythm_Homo sapiens_hsa047100.56883864
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.56299700
91Glucagon signaling pathway_Homo sapiens_hsa049220.56135865
92Arachidonic acid metabolism_Homo sapiens_hsa005900.56128297
93Alzheimers disease_Homo sapiens_hsa050100.54667214
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53636831
95Chemical carcinogenesis_Homo sapiens_hsa052040.51847282
96Inositol phosphate metabolism_Homo sapiens_hsa005620.51692521
97Wnt signaling pathway_Homo sapiens_hsa043100.51467831
98Type I diabetes mellitus_Homo sapiens_hsa049400.51301956
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.49272373
100Retinol metabolism_Homo sapiens_hsa008300.48216959
101Hippo signaling pathway_Homo sapiens_hsa043900.47808618
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46720686
103Alcoholism_Homo sapiens_hsa050340.45720122
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44382673
105Propanoate metabolism_Homo sapiens_hsa006400.44275788
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43010330
107Basal transcription factors_Homo sapiens_hsa030220.42998324
108Renal cell carcinoma_Homo sapiens_hsa052110.42075713
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40626824
110Ovarian steroidogenesis_Homo sapiens_hsa049130.39191457
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39132169
112Hedgehog signaling pathway_Homo sapiens_hsa043400.37194730
113Endometrial cancer_Homo sapiens_hsa052130.37140558
114Non-small cell lung cancer_Homo sapiens_hsa052230.36681378
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.36409072
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35955379
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35543948
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35453864
119mTOR signaling pathway_Homo sapiens_hsa041500.34897470
120Rheumatoid arthritis_Homo sapiens_hsa053230.33535212
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33237769
122Chemokine signaling pathway_Homo sapiens_hsa040620.33021831
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32935889
124Peroxisome_Homo sapiens_hsa041460.31989432
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31639871
126Fanconi anemia pathway_Homo sapiens_hsa034600.31396491
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31256768
128Prion diseases_Homo sapiens_hsa050200.30102268
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28928630
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28632287
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28571977
132Endocytosis_Homo sapiens_hsa041440.28003881
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27772710
134Insulin signaling pathway_Homo sapiens_hsa049100.26523212
135Oxidative phosphorylation_Homo sapiens_hsa001900.26274216
136Bile secretion_Homo sapiens_hsa049760.21923192

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