CDK9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.35090001
2translational termination (GO:0006415)5.06566017
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60738010
4negative regulation of cell killing (GO:0031342)4.60738010
5ribosomal small subunit biogenesis (GO:0042274)4.29478624
6translational elongation (GO:0006414)4.26244048
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.16964583
8response to peptidoglycan (GO:0032494)4.01849650
9viral life cycle (GO:0019058)4.01478367
10ribosomal small subunit assembly (GO:0000028)3.96090074
11mannose metabolic process (GO:0006013)3.95844518
12maturation of SSU-rRNA (GO:0030490)3.84593331
13translational initiation (GO:0006413)3.83585038
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.81124974
15cellular protein complex disassembly (GO:0043624)3.80224825
16positive regulation of gamma-delta T cell activation (GO:0046645)3.79968040
17negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78852553
18protein targeting to ER (GO:0045047)3.75397348
19cotranslational protein targeting to membrane (GO:0006613)3.71701660
20regulation of B cell receptor signaling pathway (GO:0050855)3.66445293
21NIK/NF-kappaB signaling (GO:0038061)3.61436576
22negative regulation of RNA splicing (GO:0033119)3.59841313
23establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56845794
24positive regulation by symbiont of host defense response (GO:0052509)3.53037960
25modulation by symbiont of host defense response (GO:0052031)3.53037960
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.53037960
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.53037960
28Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52132125
29protein complex disassembly (GO:0043241)3.52008785
30protein localization to endoplasmic reticulum (GO:0070972)3.45225795
31DNA unwinding involved in DNA replication (GO:0006268)3.39320680
32negative regulation of mRNA processing (GO:0050686)3.39158986
33positive thymic T cell selection (GO:0045059)3.38537615
34B cell receptor signaling pathway (GO:0050853)3.38038381
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33045340
36germinal center formation (GO:0002467)3.29685004
37macrophage activation involved in immune response (GO:0002281)3.28183579
38protein localization to endosome (GO:0036010)3.27213934
39macromolecular complex disassembly (GO:0032984)3.24369081
40ribosomal large subunit biogenesis (GO:0042273)3.24245250
41activation of MAPKKK activity (GO:0000185)3.19831210
42regulation of gamma-delta T cell differentiation (GO:0045586)3.16413893
43detection of other organism (GO:0098543)3.12488167
44lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08783762
453-UTR-mediated mRNA stabilization (GO:0070935)3.08555640
46detection of bacterium (GO:0016045)3.04597980
47nuclear-transcribed mRNA catabolic process (GO:0000956)3.02902247
48negative regulation of mRNA metabolic process (GO:1903312)3.01912138
49heterochromatin organization (GO:0070828)3.00198274
50regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00185443
51modulation by symbiont of host cellular process (GO:0044068)2.96457209
52negative regulation of phagocytosis (GO:0050765)2.94623124
53neutrophil activation involved in immune response (GO:0002283)2.94234163
54positive regulation of Rap GTPase activity (GO:0032854)2.93780667
55leukocyte aggregation (GO:0070486)2.93213932
56mRNA catabolic process (GO:0006402)2.91039067
57regulation of gamma-delta T cell activation (GO:0046643)2.90616136
58regulation of leukocyte degranulation (GO:0043300)2.87990257
59RNA catabolic process (GO:0006401)2.84675993
60pinocytosis (GO:0006907)2.84572523
61positive regulation of Cdc42 GTPase activity (GO:0043089)2.83581114
62negative regulation of erythrocyte differentiation (GO:0045647)2.81343061
63DNA strand elongation involved in DNA replication (GO:0006271)2.76160921
64regulation of T-helper 2 cell differentiation (GO:0045628)2.75987578
65regulation of B cell differentiation (GO:0045577)2.75836831
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74145298
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74145298
68antigen processing and presentation of endogenous antigen (GO:0019883)2.72105123
69type I interferon signaling pathway (GO:0060337)2.71913819
70cellular response to type I interferon (GO:0071357)2.71913819
71response to type I interferon (GO:0034340)2.71877818
72protein localization to kinetochore (GO:0034501)2.71677730
73barbed-end actin filament capping (GO:0051016)2.71025939
74DNA replication initiation (GO:0006270)2.70334527
75negative regulation of cytokine production involved in immune response (GO:0002719)2.69136571
76mature B cell differentiation (GO:0002335)2.68465505
77negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.68183622
78stress fiber assembly (GO:0043149)2.67489171
79regulation of monocyte differentiation (GO:0045655)2.67109870
80regulation of myeloid leukocyte mediated immunity (GO:0002886)2.66216299
81thymic T cell selection (GO:0045061)2.64317716
82modulation by virus of host process (GO:0019054)2.61957048
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.61126598
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.61031034
85regulation of ARF protein signal transduction (GO:0032012)2.59213464
86DNA strand elongation (GO:0022616)2.59167715
87positive regulation of lamellipodium assembly (GO:0010592)2.58988942
88telomere maintenance via semi-conservative replication (GO:0032201)2.57438957
89ribonucleoprotein complex biogenesis (GO:0022613)2.56320721
90actin nucleation (GO:0045010)2.56106574
91RNA stabilization (GO:0043489)2.56028685
92mRNA stabilization (GO:0048255)2.56028685
93regulation of interferon-beta biosynthetic process (GO:0045357)2.54220657
94regulation of mast cell degranulation (GO:0043304)2.53592327
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.53474211
96positive regulation of protein homooligomerization (GO:0032464)2.52903934
97positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51918666
98regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51605183
99protein targeting to membrane (GO:0006612)2.51503000
100alternative mRNA splicing, via spliceosome (GO:0000380)2.51494835
101positive regulation of B cell differentiation (GO:0045579)2.51331455
102positive T cell selection (GO:0043368)2.51065526
103regulation of vitamin D biosynthetic process (GO:0060556)2.50891845
104detection of external biotic stimulus (GO:0098581)2.50831535
105positive regulation of cellular amide metabolic process (GO:0034250)2.50458032
106cellular response to zinc ion (GO:0071294)2.50380115
107ncRNA 3-end processing (GO:0043628)2.49856878
108termination of RNA polymerase II transcription (GO:0006369)2.49637606
109immunoglobulin mediated immune response (GO:0016064)2.49439021
110epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49005399
111regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48576658
112response to muramyl dipeptide (GO:0032495)2.47985114
113CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.46378240
114protein localization to chromosome, centromeric region (GO:0071459)2.45472781
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.45398040
116cellular extravasation (GO:0045123)2.45098450
117cellular response to thyroid hormone stimulus (GO:0097067)2.43956969
118B cell mediated immunity (GO:0019724)2.43479603
119regulation of superoxide anion generation (GO:0032928)2.43228718
120glycosphingolipid catabolic process (GO:0046479)2.42241392
121negative regulation of interleukin-12 production (GO:0032695)2.41852781
122formation of translation preinitiation complex (GO:0001731)2.40906956
123regulation of macrophage cytokine production (GO:0010935)2.40261815
124negative regulation of innate immune response (GO:0045824)2.39901057
125regulation of necroptotic process (GO:0060544)2.39612652
126myeloid dendritic cell differentiation (GO:0043011)2.39422646
127positive regulation of protein dephosphorylation (GO:0035307)2.39318287
128response to protozoan (GO:0001562)2.39304006
129regulation of protein heterodimerization activity (GO:0043497)2.37563409
130signal complex assembly (GO:0007172)2.37039377
131defense response to protozoan (GO:0042832)2.36538283
132negative regulation of leukocyte mediated immunity (GO:0002704)2.34995404
133negative regulation of histone methylation (GO:0031061)2.34948298
134negative thymic T cell selection (GO:0045060)2.34747865
135DNA replication checkpoint (GO:0000076)2.34375085
136JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.32817445
137positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.32548923
138T cell homeostasis (GO:0043029)2.31933899
139negative regulation of granulocyte differentiation (GO:0030853)2.31929358
140negative T cell selection (GO:0043383)2.31582627
141pentose-phosphate shunt (GO:0006098)2.31576557
142negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31439893
143negative regulation of type 2 immune response (GO:0002829)2.31385958
144interferon-gamma-mediated signaling pathway (GO:0060333)2.31356411
145regulation of regulated secretory pathway (GO:1903305)2.31250488
146respiratory burst (GO:0045730)2.30414021
147activation of JUN kinase activity (GO:0007257)2.30100937
148response to laminar fluid shear stress (GO:0034616)2.30077001
149natural killer cell differentiation (GO:0001779)2.29367771
150mature B cell differentiation involved in immune response (GO:0002313)2.29140352
151positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29046044
152T cell selection (GO:0045058)2.28864254
153positive regulation of extracellular matrix organization (GO:1903055)2.28400148
154regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.28300093
155positive regulation of mast cell activation (GO:0033005)2.28045864
156dosage compensation (GO:0007549)2.27628676
157regulation of histone H3-K9 methylation (GO:0051570)2.27105862
158intracellular estrogen receptor signaling pathway (GO:0030520)2.26808963
159adenosine receptor signaling pathway (GO:0001973)2.26399176
160regulation of necrotic cell death (GO:0010939)2.26394218
161macrophage activation (GO:0042116)2.26369074
162embryonic process involved in female pregnancy (GO:0060136)2.26356134
163T cell apoptotic process (GO:0070231)2.26166791
164regulation of lipid kinase activity (GO:0043550)2.26085330
165regulation of early endosome to late endosome transport (GO:2000641)2.25749089
166antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25727203
167negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.25573460
168antigen receptor-mediated signaling pathway (GO:0050851)2.23861635
169regulation of erythrocyte differentiation (GO:0045646)2.23132170
170regulation of T-helper 1 cell differentiation (GO:0045625)2.21517781
171negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.20891721
172megakaryocyte development (GO:0035855)2.20321732
173rRNA processing (GO:0006364)2.19839581
174modulation by symbiont of host immune response (GO:0052553)2.19202958
175modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.19202958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.81503223
2MYC_22102868_ChIP-Seq_BL_Human3.71282604
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.68682870
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.60739176
5VDR_21846776_ChIP-Seq_THP-1_Human3.35675053
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.78646334
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64771843
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.56002419
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41988609
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32377137
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27824902
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.25986934
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21329736
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18765691
15* MAF_26560356_Chip-Seq_TH1_Human2.11672986
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05140679
17VDR_24763502_ChIP-Seq_THP-1_Human2.04125899
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01504992
19* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98448419
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97652709
21* KDM2B_26808549_Chip-Seq_DND41_Human1.97435390
22* UTX_26944678_Chip-Seq_JUKART_Human1.97073550
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93163567
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92679197
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92607010
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.91337754
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85597838
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.84332372
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80133940
30* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78944635
31SPI1_23547873_ChIP-Seq_NB4_Human1.78615862
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75181344
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74692494
34KDM2B_26808549_Chip-Seq_K562_Human1.74236376
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72079298
36SCL_19346495_ChIP-Seq_HPC-7_Human1.71516576
37XRN2_22483619_ChIP-Seq_HELA_Human1.70740958
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70117041
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69273745
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68777648
41* RUNX1_22412390_ChIP-Seq_EML_Mouse1.68077786
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.66190576
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65824507
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62673403
45* MYB_26560356_Chip-Seq_TH1_Human1.62425110
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61823171
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60919144
48MYB_26560356_Chip-Seq_TH2_Human1.58701400
49MAF_26560356_Chip-Seq_TH2_Human1.58360354
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53503469
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.53298636
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51365133
53* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51239796
54LXR_22292898_ChIP-Seq_THP-1_Human1.50822417
55* IRF8_27001747_Chip-Seq_BMDM_Mouse1.50816800
56* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48506131
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48304002
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48304002
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48304002
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46952750
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.45964798
62* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41922447
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39249203
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.39094276
65CIITA_25753668_ChIP-Seq_RAJI_Human1.37889947
66CLOCK_20551151_ChIP-Seq_293T_Human1.37784851
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.36492813
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36460190
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35048465
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34089980
71* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32061671
72* P68_20966046_ChIP-Seq_HELA_Human1.31384498
73* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31125478
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30977596
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.30771457
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.30430576
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30119344
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30069164
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29533452
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28054715
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27440474
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26729509
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26546975
84TTF2_22483619_ChIP-Seq_HELA_Human1.25893244
85SPI1_23127762_ChIP-Seq_K562_Human1.24909868
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22443708
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22212943
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.22158371
89NCOR1_26117541_ChIP-Seq_K562_Human1.21030814
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19955713
91SMC4_20622854_ChIP-Seq_HELA_Human1.19622783
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.19456126
93GATA1_19941826_ChIP-Seq_K562_Human1.19308829
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19066143
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18752753
96RACK7_27058665_Chip-Seq_MCF-7_Human1.18638142
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16679252
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16544440
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15177176
100KDM5A_27292631_Chip-Seq_BREAST_Human1.13634258
101CREB1_26743006_Chip-Seq_LNCaP_Human1.13218054
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12984170
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11952906
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11811130
105ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11599742
106BCOR_27268052_Chip-Seq_Bcells_Human1.11410998
107* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11386146
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10764556
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09422776
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08715261
111ETS1_20019798_ChIP-Seq_JURKAT_Human1.08454016
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08095076
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07601367
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07388415
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05984960
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05814161
117DCP1A_22483619_ChIP-Seq_HELA_Human1.05793138
118TFEB_21752829_ChIP-Seq_HELA_Human1.05543786
119FOXP3_21729870_ChIP-Seq_TREG_Human1.04627544
120* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03854712
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03577932
122VDR_23849224_ChIP-Seq_CD4+_Human1.03078828
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02751305
124* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02129537
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01772049
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01225057
127SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01003169
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00397611
129SA1_27219007_Chip-Seq_ERYTHROID_Human0.99390710
130TP63_17297297_ChIP-ChIP_HaCaT_Human0.98091465
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97901460
132RUNX_20019798_ChIP-Seq_JUKART_Human0.97836856
133* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97145641
134NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96208750
135NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95033562
136ATF3_27146783_Chip-Seq_COLON_Human0.94706869
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94229917
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93418895
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90244667
140* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89564809
141PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89360484
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.88656595
143* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87975245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.12509309
2MP0009278_abnormal_bone_marrow3.31713496
3MP0005058_abnormal_lysosome_morphology3.31180834
4MP0003172_abnormal_lysosome_physiology2.71438372
5MP0000685_abnormal_immune_system2.58413121
6MP0008260_abnormal_autophagy2.54402650
7MP0009840_abnormal_foam_cell2.47431814
8MP0001800_abnormal_humoral_immune2.42207551
9MP0008057_abnormal_DNA_replication2.40212704
10MP0005397_hematopoietic_system_phenotyp2.30500329
11MP0001545_abnormal_hematopoietic_system2.30500329
12MP0005451_abnormal_body_composition2.29854789
13MP0005174_abnormal_tail_pigmentation2.29581155
14MP0003763_abnormal_thymus_physiology2.26758331
15MP0009379_abnormal_foot_pigmentation2.26698627
16MP0002396_abnormal_hematopoietic_system2.23422956
17MP0003436_decreased_susceptibility_to2.22966401
18MP0003693_abnormal_embryo_hatching2.21725059
19MP0003111_abnormal_nucleus_morphology2.21636228
20MP0003191_abnormal_cellular_cholesterol2.20816136
21MP0002398_abnormal_bone_marrow2.16552619
22MP0002452_abnormal_antigen_presenting2.16182846
23MP0004808_abnormal_hematopoietic_stem2.10291001
24MP0002420_abnormal_adaptive_immunity2.05760454
25MP0001790_abnormal_immune_system2.05100299
26MP0005387_immune_system_phenotype2.05100299
27MP0001819_abnormal_immune_cell2.03313326
28MP0004957_abnormal_blastocyst_morpholog2.01960129
29MP0010094_abnormal_chromosome_stability2.00410709
30MP0001835_abnormal_antigen_presentation1.97275041
31MP0005000_abnormal_immune_tolerance1.96706027
32MP0009333_abnormal_splenocyte_physiolog1.95914411
33MP0002723_abnormal_immune_serum1.95389193
34MP0005076_abnormal_cell_differentiation1.91386718
35MP0000689_abnormal_spleen_morphology1.82643975
36MP0003300_gastrointestinal_ulcer1.82396398
37MP0001849_ear_inflammation1.81697859
38MP0000490_abnormal_crypts_of1.81107046
39MP0005671_abnormal_response_to1.79958539
40MP0002405_respiratory_system_inflammati1.78743266
41MP0003077_abnormal_cell_cycle1.77511789
42MP0000716_abnormal_immune_system1.76208515
43MP0002722_abnormal_immune_system1.75197183
44MP0000703_abnormal_thymus_morphology1.74798903
45MP0005025_abnormal_response_to1.73253868
46MP0003091_abnormal_cell_migration1.71437928
47MP0003329_amyloid_beta_deposits1.62841131
48MP0002419_abnormal_innate_immunity1.60295293
49MP0000604_amyloidosis1.60282434
50MP0002429_abnormal_blood_cell1.56466475
51MP0005464_abnormal_platelet_physiology1.52394773
52MP0009785_altered_susceptibility_to1.51885547
53MP0010352_gastrointestinal_tract_polyps1.49191555
54MP0001873_stomach_inflammation1.47103630
55MP0002148_abnormal_hypersensitivity_rea1.45546967
56MP0001853_heart_inflammation1.44581120
57MP0003448_altered_tumor_morphology1.44132440
58MP0002998_abnormal_bone_remodeling1.43687406
59MP0010307_abnormal_tumor_latency1.43530763
60MP0003690_abnormal_glial_cell1.41186898
61MP0003724_increased_susceptibility_to1.40290893
62MP0000858_altered_metastatic_potential1.39559983
63MP0008007_abnormal_cellular_replicative1.37780251
64MP0010155_abnormal_intestine_physiology1.34893531
65MP0005666_abnormal_adipose_tissue1.34690992
66MP0003866_abnormal_defecation1.33597551
67MP0000350_abnormal_cell_proliferation1.32025321
68MP0002019_abnormal_tumor_incidence1.27250736
69MP0004510_myositis1.24060407
70MP0004947_skin_inflammation1.22264915
71MP0002166_altered_tumor_susceptibility1.19086920
72MP0005409_darkened_coat_color1.18536488
73MP0001730_embryonic_growth_arrest1.17105149
74MP0002138_abnormal_hepatobiliary_system1.15118941
75MP0003453_abnormal_keratinocyte_physiol1.14876639
76MP0003566_abnormal_cell_adhesion1.11837868
77MP0006082_CNS_inflammation1.11762237
78MP0005166_decreased_susceptibility_to1.08373997
79MP0000465_gastrointestinal_hemorrhage1.07612386
80MP0001845_abnormal_inflammatory_respons1.06240828
81MP0003279_aneurysm1.06005259
82MP0005375_adipose_tissue_phenotype1.04136753
83MP0008469_abnormal_protein_level1.03259117
84MP0004185_abnormal_adipocyte_glucose1.02263079
85MP0002006_tumorigenesis0.99538428
86MP0002933_joint_inflammation0.99014856
87MP0000313_abnormal_cell_death0.97018594
88MP0003828_pulmonary_edema0.96993716
89MP0000343_altered_response_to0.95562301
90MP0001851_eye_inflammation0.95514586
91MP0008874_decreased_physiological_sensi0.93280469
92MP0002254_reproductive_system_inflammat0.92922172
93MP0005023_abnormal_wound_healing0.92746384
94MP0005310_abnormal_salivary_gland0.91850318
95MP0003183_abnormal_peptide_metabolism0.91809927
96MP0002877_abnormal_melanocyte_morpholog0.90553275
97MP0005390_skeleton_phenotype0.89958872
98MP0003656_abnormal_erythrocyte_physiolo0.89258477
99MP0008058_abnormal_DNA_repair0.88466612
100MP0002086_abnormal_extraembryonic_tissu0.88449335
101MP0000015_abnormal_ear_pigmentation0.87644493
102MP0001533_abnormal_skeleton_physiology0.87109410
103MP0005621_abnormal_cell_physiology0.86834981
104MP0005501_abnormal_skin_physiology0.84888030
105MP0005167_abnormal_blood-brain_barrier0.84827806
106MP0005165_increased_susceptibility_to0.84674501
107MP0000767_abnormal_smooth_muscle0.83201877
108MP0002080_prenatal_lethality0.81834054
109MP0008995_early_reproductive_senescence0.81705252
110MP0000249_abnormal_blood_vessel0.80318380
111MP0008004_abnormal_stomach_pH0.79405888
112MP0008932_abnormal_embryonic_tissue0.78373226
113MP0001697_abnormal_embryo_size0.78066946
114MP0002085_abnormal_embryonic_tissue0.75317087
115MP0008877_abnormal_DNA_methylation0.74666203
116MP0002796_impaired_skin_barrier0.73882672
117MP0002084_abnormal_developmental_patter0.72268705
118MP0009764_decreased_sensitivity_to0.71690761
119MP0000477_abnormal_intestine_morphology0.71465810
120MP0004858_abnormal_nervous_system0.70992055
121MP0003075_altered_response_to0.70193547
122MP0008770_decreased_survivor_rate0.69723481
123MP0005380_embryogenesis_phenotype0.69526790
124MP0001672_abnormal_embryogenesis/_devel0.69526790
125MP0000003_abnormal_adipose_tissue0.69520252
126MP0005164_abnormal_response_to0.68880866
127MP0000920_abnormal_myelination0.68106389
128MP0003795_abnormal_bone_structure0.67463099
129MP0003705_abnormal_hypodermis_morpholog0.67417651
130MP0002089_abnormal_postnatal_growth/wei0.67283222
131MP0004197_abnormal_fetal_growth/weight/0.67049254
132MP0003786_premature_aging0.66019799
133MP0003123_paternal_imprinting0.65930917
134MP0003984_embryonic_growth_retardation0.64792616
135MP0003634_abnormal_glial_cell0.64408732
136MP0002088_abnormal_embryonic_growth/wei0.63390492
137MP0001663_abnormal_digestive_system0.62271259
138MP0003136_yellow_coat_color0.62228893
139MP0009931_abnormal_skin_appearance0.62103077

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.92626656
2Recurrent abscess formation (HP:0002722)3.79445377
3Cellulitis (HP:0100658)3.60257443
4Abnormality of cells of the erythroid lineage (HP:0012130)3.54112344
5Eczematoid dermatitis (HP:0000976)3.50195912
6Chronic obstructive pulmonary disease (HP:0006510)3.43013544
7Obstructive lung disease (HP:0006536)3.43013544
8Abnormal number of erythroid precursors (HP:0012131)3.25247058
9Recurrent fungal infections (HP:0002841)3.24706651
10Dysostosis multiplex (HP:0000943)3.24337815
11Abnormality of glycolipid metabolism (HP:0010969)3.10498367
12Abnormality of liposaccharide metabolism (HP:0010968)3.10498367
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.10498367
14Recurrent bacterial skin infections (HP:0005406)3.05912559
15Mediastinal lymphadenopathy (HP:0100721)3.03537376
16Polygenic inheritance (HP:0010982)3.01835919
17Spontaneous hematomas (HP:0007420)2.92565828
18Recurrent viral infections (HP:0004429)2.91382410
19Hematochezia (HP:0002573)2.91191247
20Abnormal delayed hypersensitivity skin test (HP:0002963)2.90451265
21Loss of speech (HP:0002371)2.79779877
22Gastrointestinal inflammation (HP:0004386)2.79385506
23Chronic otitis media (HP:0000389)2.77712080
24Pustule (HP:0200039)2.77537535
25Inflammation of the large intestine (HP:0002037)2.74017203
26Pallor (HP:0000980)2.73746699
27Abnormality of the nasal mucosa (HP:0000433)2.71046104
28Obstructive sleep apnea (HP:0002870)2.69249672
29Increased IgE level (HP:0003212)2.65090889
30Neurofibrillary tangles (HP:0002185)2.64650454
31Systemic lupus erythematosus (HP:0002725)2.64322951
32Panhypogammaglobulinemia (HP:0003139)2.62102555
33Meningitis (HP:0001287)2.61925318
34Nasal polyposis (HP:0100582)2.59435677
35Nuclear cataract (HP:0100018)2.55924158
36Colitis (HP:0002583)2.52093165
37Basal cell carcinoma (HP:0002671)2.51073700
38Broad face (HP:0000283)2.48412352
39Chronic mucocutaneous candidiasis (HP:0002728)2.44834645
40Recurrent cutaneous fungal infections (HP:0011370)2.44834645
41Elevated erythrocyte sedimentation rate (HP:0003565)2.44235581
42Stomatitis (HP:0010280)2.40881247
43Neuronal loss in central nervous system (HP:0002529)2.40508296
44Agammaglobulinemia (HP:0004432)2.38942691
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38566190
46Abnormality of polysaccharide metabolism (HP:0011012)2.38566190
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38566190
48Selective tooth agenesis (HP:0001592)2.38201380
49Thrombocytosis (HP:0001894)2.36300452
50Mucopolysacchariduria (HP:0008155)2.35571985
51Urinary glycosaminoglycan excretion (HP:0003541)2.35571985
52Cerebral inclusion bodies (HP:0100314)2.34712537
53Gastrointestinal stroma tumor (HP:0100723)2.34559252
54Prolonged bleeding time (HP:0003010)2.32064184
55Macrocytic anemia (HP:0001972)2.31719458
56IgM deficiency (HP:0002850)2.30954484
57Absent thumb (HP:0009777)2.28611076
58Distal lower limb amyotrophy (HP:0008944)2.27440384
59Fatigue (HP:0012378)2.27214685
60Verrucae (HP:0200043)2.26834624
61Papilloma (HP:0012740)2.26834624
62Supranuclear gaze palsy (HP:0000605)2.26330782
63Thin bony cortex (HP:0002753)2.24069187
64Vertebral compression fractures (HP:0002953)2.21441594
65Hypochromic anemia (HP:0001931)2.21430414
66Orchitis (HP:0100796)2.19560121
67Myocardial infarction (HP:0001658)2.16758632
68Amyloidosis (HP:0011034)2.15886548
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14423935
70Recurrent skin infections (HP:0001581)2.12109251
71T lymphocytopenia (HP:0005403)2.11002719
72Cerebral aneurysm (HP:0004944)2.08147426
73Abnormality of T cells (HP:0002843)2.07329942
74Abnormality of T cell number (HP:0011839)2.07088836
75Abnormality of the thoracic spine (HP:0100711)2.07071525
76Recurrent bronchitis (HP:0002837)2.06895752
77Slow saccadic eye movements (HP:0000514)2.05316387
78Abnormality of the fingertips (HP:0001211)2.03565667
79Chronic sinusitis (HP:0011109)2.03445938
80Annular pancreas (HP:0001734)2.02053721
81Long palpebral fissure (HP:0000637)2.01623294
82Thoracic kyphosis (HP:0002942)2.01069319
83Purpura (HP:0000979)2.00621151
84Distal lower limb muscle weakness (HP:0009053)2.00408233
85Myositis (HP:0100614)1.99894223
86Peripheral hypomyelination (HP:0007182)1.99713205
87Abnormality of cells of the lymphoid lineage (HP:0012140)1.99474345
88Acute lymphatic leukemia (HP:0006721)1.97360653
89Sparse lateral eyebrow (HP:0005338)1.95538426
90Emphysema (HP:0002097)1.94976335
91Breast hypoplasia (HP:0003187)1.94870614
92Concave nail (HP:0001598)1.94477810
93Increased connective tissue (HP:0009025)1.91528829
94Genu recurvatum (HP:0002816)1.91422090
95Petechiae (HP:0000967)1.90828657
96Apathy (HP:0000741)1.90142307
97Vasculitis (HP:0002633)1.88820428
98Centrally nucleated skeletal muscle fibers (HP:0003687)1.88703195
99Agnosia (HP:0010524)1.88394043
100Facial hemangioma (HP:0000329)1.87500709
101Asplenia (HP:0001746)1.87141052
102Increased cerebral lipofuscin (HP:0011813)1.86975806
103Myelodysplasia (HP:0002863)1.86251419
104Abnormality of T cell physiology (HP:0011840)1.85364032
105Hypertensive crisis (HP:0100735)1.85289589
106Leukocytosis (HP:0001974)1.84801501
107Increased serum ferritin (HP:0003281)1.84769769
108Increased density of long bones (HP:0006392)1.84195812
109Vacuolated lymphocytes (HP:0001922)1.82928764
110Abnormality of macrophages (HP:0004311)1.81323180
111Lymphoma (HP:0002665)1.81205325
112Difficulty climbing stairs (HP:0003551)1.80927887
113Thyroiditis (HP:0100646)1.80248637
114Hepatosplenomegaly (HP:0001433)1.79472487
115Lymphopenia (HP:0001888)1.79464138
116Segmental peripheral demyelination/remyelination (HP:0003481)1.79244215
117Axonal loss (HP:0003447)1.78721514
118Restrictive lung disease (HP:0002091)1.78136758
119Lower limb amyotrophy (HP:0007210)1.77816385
120Optic neuritis (HP:0100653)1.77069247
121Retrobulbar optic neuritis (HP:0100654)1.77069247
122Interstitial pulmonary disease (HP:0006530)1.76855588
123Hypertriglyceridemia (HP:0002155)1.76177562
124Abnormality of complement system (HP:0005339)1.75476294
125Hyperacusis (HP:0010780)1.74660133
126Esophageal varix (HP:0002040)1.74653175
127Urticaria (HP:0001025)1.73819204
128Polycythemia (HP:0001901)1.73460685
129Gingivitis (HP:0000230)1.72462168
130Hypergammaglobulinemia (HP:0010702)1.71557610
131Recurrent gram-negative bacterial infections (HP:0005420)1.71091656
132Epistaxis (HP:0000421)1.70929250
133Cervical subluxation (HP:0003308)1.70813797
134Osteomyelitis (HP:0002754)1.70789650
135High pitched voice (HP:0001620)1.70701067
136Upper motor neuron abnormality (HP:0002127)1.70238984
137Impaired platelet aggregation (HP:0003540)1.70043313
138Abnormal platelet function (HP:0011869)1.70043313
139Cheilitis (HP:0100825)1.68863168
140Deep palmar crease (HP:0006191)1.68749565
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.68012675
142Protrusio acetabuli (HP:0003179)1.67684687
143Achilles tendon contracture (HP:0001771)1.66659614
144Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66403411
145Abnormality of DNA repair (HP:0003254)1.65740187
146Autoimmune thrombocytopenia (HP:0001973)1.64789992
147Ankle clonus (HP:0011448)1.64293115
148Abnormality of the columella (HP:0009929)1.63332271
149Eosinophilia (HP:0001880)1.63016933
150Distal upper limb amyotrophy (HP:0007149)1.61706421
151Diminished motivation (HP:0000745)1.61667519
152Patellar aplasia (HP:0006443)1.60880995
153Tracheoesophageal fistula (HP:0002575)1.60458908
154Increased neuronal autofluorescent lipopigment (HP:0002074)1.60380646
155Squamous cell carcinoma (HP:0002860)1.60317336
156Basal ganglia calcification (HP:0002135)1.59310955
157Abnormal platelet volume (HP:0011876)1.58712928
158Porencephaly (HP:0002132)1.58452801
159Aplasia/Hypoplasia of the thymus (HP:0010515)1.58362933
160Rectal prolapse (HP:0002035)1.57080216
161Bicuspid aortic valve (HP:0001647)1.56763937
162Recurrent sinusitis (HP:0011108)1.56355326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.38438673
2MAP4K12.96761706
3EEF2K2.87462116
4TRIB32.84575418
5SMG12.74305257
6PKN22.57518072
7BLK2.55665043
8FES2.43887515
9RIPK12.23522641
10RIPK42.16258858
11SIK12.13978950
12GRK61.92379506
13NME21.91114755
14MAP3K111.86473668
15CSK1.78991515
16NEK21.78964473
17STK101.74975419
18TAOK21.74408818
19CDK121.73324755
20MAP3K141.65313546
21SIK21.64257769
22RPS6KA41.64113508
23CDC71.59064763
24MAP3K31.57559707
25ALK1.50642293
26TLK11.49083131
27PRKD21.46998690
28FGFR41.44463245
29FGR1.42159391
30MARK21.40259968
31ZAP701.39278702
32LRRK21.39169131
33BTK1.38981666
34MAP3K131.38001729
35CDK41.37697830
36MAP3K11.35780530
37CLK11.33949824
38HCK1.33431183
39DYRK31.31343964
40MAP2K31.31017212
41IRAK41.30247632
42TBK11.25883461
43SIK31.20432266
44MKNK21.13414277
45PIM11.13170291
46TAOK11.11098219
47CDK61.10527250
48CDK71.09267764
49PAK41.08622395
50TYK21.07492652
51MAP3K61.05708425
52WEE11.03614372
53RPS6KB21.02147778
54ERN11.00391687
55CDC42BPA1.00172240
56MAP3K80.99594731
57PIM20.98605789
58IRAK30.98027324
59LCK0.97878495
60BRD40.97805598
61SYK0.97028144
62JAK30.93297935
63PDGFRA0.92855077
64PTK60.91502094
65ARAF0.90035072
66PRPF4B0.89206904
67NLK0.89194169
68KIT0.86747100
69TTN0.85515549
70BMX0.80423517
71IKBKB0.80001060
72MAPK120.79769652
73TGFBR20.79760744
74JAK10.79673569
75TYRO30.79218191
76LYN0.77711452
77PDPK10.76509166
78IRAK20.76199205
79DDR20.75602268
80TEC0.74654421
81CDK190.73936126
82MTOR0.71387660
83BUB10.71384997
84ITK0.70433849
85MATK0.69192380
86KSR20.68704195
87MAPK150.68554510
88CSF1R0.68141558
89MELK0.66548010
90HIPK20.65315339
91MAPK110.64986585
92TNK20.64640567
93LATS20.61963497
94MAPKAPK30.61613911
95NTRK10.61406684
96MAP3K90.60727847
97RPS6KA20.60528081
98KDR0.60327148
99PDK10.59758642
100DAPK10.59540380
101MAP2K20.58755061
102STK110.57986413
103TESK10.57323123
104MARK30.56466648
105RET0.56139987
106MAPK70.55937888
107EIF2AK10.55460771
108PRKD30.54570126
109TESK20.54082393
110MKNK10.52029480
111TIE10.51579464
112RAF10.51529429
113IKBKE0.51430130
114MAPKAPK20.51289976
115MAPK40.49215664
116FGFR30.49181039
117TGFBR10.49166723
118CDK80.47775164
119MAP3K70.47519102
120CAMKK10.46500683
121EPHB10.46475452
122MOS0.46408003
123DMPK0.46067425
124ATR0.44477366
125YES10.43914682
126JAK20.43680528
127CDK20.42462237
128ICK0.41826599
129RPS6KC10.39376319
130RPS6KL10.39376319
131PLK10.37723173
132ILK0.36980261
133PRKD10.36950852
134SGK30.36438981
135CHEK10.36292843
136CHUK0.36205632
137IRAK10.35951136
138RPS6KA60.35782583

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.90571248
2DNA replication_Homo sapiens_hsa030302.39561043
3B cell receptor signaling pathway_Homo sapiens_hsa046622.23454177
4Primary immunodeficiency_Homo sapiens_hsa053402.18830775
5Spliceosome_Homo sapiens_hsa030401.96150462
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92805857
7Mismatch repair_Homo sapiens_hsa034301.89964259
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.78505525
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77955756
10Base excision repair_Homo sapiens_hsa034101.74682446
11Leishmaniasis_Homo sapiens_hsa051401.63972021
12Osteoclast differentiation_Homo sapiens_hsa043801.62214554
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55018910
14Prion diseases_Homo sapiens_hsa050201.53356519
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49711992
16Chronic myeloid leukemia_Homo sapiens_hsa052201.46422771
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44404395
18Acute myeloid leukemia_Homo sapiens_hsa052211.43067476
19Shigellosis_Homo sapiens_hsa051311.40834715
20Staphylococcus aureus infection_Homo sapiens_hsa051501.36261994
21Antigen processing and presentation_Homo sapiens_hsa046121.35964156
22Lysosome_Homo sapiens_hsa041421.34173812
23Herpes simplex infection_Homo sapiens_hsa051681.34107928
24VEGF signaling pathway_Homo sapiens_hsa043701.32595377
25Homologous recombination_Homo sapiens_hsa034401.32215177
26T cell receptor signaling pathway_Homo sapiens_hsa046601.28149233
27mRNA surveillance pathway_Homo sapiens_hsa030151.25972178
28Cell cycle_Homo sapiens_hsa041101.25771310
29RNA transport_Homo sapiens_hsa030131.23709823
30Measles_Homo sapiens_hsa051621.21955867
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.19259659
32Allograft rejection_Homo sapiens_hsa053301.19166561
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17810509
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.17667952
35Hepatitis B_Homo sapiens_hsa051611.16110348
36p53 signaling pathway_Homo sapiens_hsa041151.12975512
37Hematopoietic cell lineage_Homo sapiens_hsa046401.12323326
38Sulfur relay system_Homo sapiens_hsa041221.10394028
39Renal cell carcinoma_Homo sapiens_hsa052111.10339734
40Nucleotide excision repair_Homo sapiens_hsa034201.07323924
41* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04876474
42HTLV-I infection_Homo sapiens_hsa051661.04312275
43Notch signaling pathway_Homo sapiens_hsa043301.04182430
44Chemokine signaling pathway_Homo sapiens_hsa040621.02914724
45Epstein-Barr virus infection_Homo sapiens_hsa051691.02904738
46Non-small cell lung cancer_Homo sapiens_hsa052231.02317379
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01635281
48Tuberculosis_Homo sapiens_hsa051521.01507674
49Bladder cancer_Homo sapiens_hsa052191.00641348
50Platelet activation_Homo sapiens_hsa046110.99650403
51Amoebiasis_Homo sapiens_hsa051460.99527237
52Apoptosis_Homo sapiens_hsa042100.99420559
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99038641
54Graft-versus-host disease_Homo sapiens_hsa053320.97192756
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.96653143
56Pancreatic cancer_Homo sapiens_hsa052120.96250332
57Colorectal cancer_Homo sapiens_hsa052100.95689341
58Fanconi anemia pathway_Homo sapiens_hsa034600.95640494
59Autoimmune thyroid disease_Homo sapiens_hsa053200.95323130
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94585403
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94439164
62African trypanosomiasis_Homo sapiens_hsa051430.92799208
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92333888
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.91550495
65MicroRNAs in cancer_Homo sapiens_hsa052060.91221057
66Legionellosis_Homo sapiens_hsa051340.90929032
67Endometrial cancer_Homo sapiens_hsa052130.90871052
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88722506
69Glioma_Homo sapiens_hsa052140.87692462
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87428707
71Influenza A_Homo sapiens_hsa051640.86679597
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.86030935
73Small cell lung cancer_Homo sapiens_hsa052220.84558236
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.83785629
75Rheumatoid arthritis_Homo sapiens_hsa053230.83629326
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82914181
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82814263
78Toxoplasmosis_Homo sapiens_hsa051450.82585586
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82296317
80ErbB signaling pathway_Homo sapiens_hsa040120.81826655
81Thyroid cancer_Homo sapiens_hsa052160.79407595
82Pertussis_Homo sapiens_hsa051330.79112271
83Other glycan degradation_Homo sapiens_hsa005110.78023399
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77386796
85Salmonella infection_Homo sapiens_hsa051320.77100969
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76619549
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.75690038
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75499477
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75218645
90Phagosome_Homo sapiens_hsa041450.74856431
91RNA polymerase_Homo sapiens_hsa030200.73547663
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.73032990
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72107583
94One carbon pool by folate_Homo sapiens_hsa006700.71032058
95Viral carcinogenesis_Homo sapiens_hsa052030.70784231
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70065363
97Choline metabolism in cancer_Homo sapiens_hsa052310.68975329
98Type I diabetes mellitus_Homo sapiens_hsa049400.68797230
99TNF signaling pathway_Homo sapiens_hsa046680.68082557
100Inositol phosphate metabolism_Homo sapiens_hsa005620.67438086
101Asthma_Homo sapiens_hsa053100.66528945
102Proteoglycans in cancer_Homo sapiens_hsa052050.64416159
103Viral myocarditis_Homo sapiens_hsa054160.63889467
104Insulin signaling pathway_Homo sapiens_hsa049100.63597751
105Long-term potentiation_Homo sapiens_hsa047200.62846811
106Prolactin signaling pathway_Homo sapiens_hsa049170.62436833
107Pentose phosphate pathway_Homo sapiens_hsa000300.62176655
108GnRH signaling pathway_Homo sapiens_hsa049120.61926921
109mTOR signaling pathway_Homo sapiens_hsa041500.61762374
110Fructose and mannose metabolism_Homo sapiens_hsa000510.61699396
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61187812
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60920979
113Estrogen signaling pathway_Homo sapiens_hsa049150.60465196
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59440784
115MAPK signaling pathway_Homo sapiens_hsa040100.59139018
116Pyrimidine metabolism_Homo sapiens_hsa002400.58438694
117HIF-1 signaling pathway_Homo sapiens_hsa040660.58384178
118Insulin resistance_Homo sapiens_hsa049310.58333088
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57915565
120Oocyte meiosis_Homo sapiens_hsa041140.57721474
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57597163
122Dorso-ventral axis formation_Homo sapiens_hsa043200.57280027
123Long-term depression_Homo sapiens_hsa047300.57103012
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.56787372
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55825921
126Olfactory transduction_Homo sapiens_hsa047400.55433385
127FoxO signaling pathway_Homo sapiens_hsa040680.55406186
128TGF-beta signaling pathway_Homo sapiens_hsa043500.55222144
129Pathways in cancer_Homo sapiens_hsa052000.54848002
130Prostate cancer_Homo sapiens_hsa052150.53955022
131Hepatitis C_Homo sapiens_hsa051600.52290979
132Rap1 signaling pathway_Homo sapiens_hsa040150.51511655
133Endocytosis_Homo sapiens_hsa041440.51392956
134Malaria_Homo sapiens_hsa051440.51092300
135Adherens junction_Homo sapiens_hsa045200.50860992

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