CDK8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.80790750
2nuclear pore organization (GO:0006999)4.59512136
3mitotic sister chromatid cohesion (GO:0007064)4.58804100
4synapsis (GO:0007129)4.27841901
5monoubiquitinated protein deubiquitination (GO:0035520)4.26012376
6mitotic metaphase plate congression (GO:0007080)4.25672952
7histone H2A monoubiquitination (GO:0035518)4.19080119
8regulation of sister chromatid cohesion (GO:0007063)4.17223356
9pre-miRNA processing (GO:0031054)3.91137274
10regulation of RNA export from nucleus (GO:0046831)3.82626162
11metaphase plate congression (GO:0051310)3.80772741
12pore complex assembly (GO:0046931)3.75466758
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73239787
14positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.63207319
15positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.63207319
16positive regulation of mitotic sister chromatid separation (GO:1901970)3.63207319
17regulation of centriole replication (GO:0046599)3.56605633
18thyroid hormone generation (GO:0006590)3.56559999
19regulation of NFAT protein import into nucleus (GO:0051532)3.49439345
20protein K6-linked ubiquitination (GO:0085020)3.48202129
21regulation of spindle organization (GO:0090224)3.44677384
22paraxial mesoderm development (GO:0048339)3.43837990
23positive regulation of DNA-templated transcription, initiation (GO:2000144)3.42339797
24meiotic chromosome segregation (GO:0045132)3.34437874
25intestinal epithelial cell development (GO:0060576)3.32035552
26folic acid-containing compound biosynthetic process (GO:0009396)3.26574805
27embryonic body morphogenesis (GO:0010172)3.25549804
28mitotic nuclear envelope disassembly (GO:0007077)3.25166870
29mitotic chromosome condensation (GO:0007076)3.23031484
30regulation of hexokinase activity (GO:1903299)3.22059526
31regulation of glucokinase activity (GO:0033131)3.22059526
32DNA synthesis involved in DNA repair (GO:0000731)3.22025368
33histone H2A ubiquitination (GO:0033522)3.21219739
34kinetochore organization (GO:0051383)3.20530539
35sister chromatid cohesion (GO:0007062)3.20488425
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.13207378
37establishment of chromosome localization (GO:0051303)3.10285739
38attachment of spindle microtubules to kinetochore (GO:0008608)3.09125664
39body morphogenesis (GO:0010171)3.06736141
40positive regulation of chromosome segregation (GO:0051984)3.05684430
41thyroid hormone metabolic process (GO:0042403)3.05316031
42DNA unwinding involved in DNA replication (GO:0006268)3.04612178
43protein localization to kinetochore (GO:0034501)3.01905389
44histone H3-K36 demethylation (GO:0070544)3.01615147
45chromosome organization involved in meiosis (GO:0070192)3.01599112
46regulation of DNA endoreduplication (GO:0032875)3.00965890
47positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.00800158
48regulation of nuclear cell cycle DNA replication (GO:0033262)2.99836098
49regulation of centrosome cycle (GO:0046605)2.99195351
50nuclear envelope disassembly (GO:0051081)2.98666391
51membrane disassembly (GO:0030397)2.98666391
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96884332
53heterochromatin organization (GO:0070828)2.94133817
54poly(A)+ mRNA export from nucleus (GO:0016973)2.92620250
55folic acid metabolic process (GO:0046655)2.91442875
56mitotic cytokinesis (GO:0000281)2.90617169
57spindle checkpoint (GO:0031577)2.90251099
58type B pancreatic cell development (GO:0003323)2.90184341
59kinetochore assembly (GO:0051382)2.90103337
60regulation of mitotic spindle organization (GO:0060236)2.89957404
61histone demethylation (GO:0016577)2.88701422
62regulation of centrosome duplication (GO:0010824)2.86833285
63CENP-A containing nucleosome assembly (GO:0034080)2.86813262
64protein localization to chromosome, centromeric region (GO:0071459)2.86750393
65negative regulation of DNA repair (GO:0045738)2.86134318
66negative regulation of histone methylation (GO:0031061)2.83956416
67male meiosis I (GO:0007141)2.83784546
68regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83533314
69histone lysine demethylation (GO:0070076)2.83440685
70positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.83190529
71N-terminal protein amino acid acetylation (GO:0006474)2.81661103
72regulation of histone H3-K9 methylation (GO:0051570)2.81034517
73sister chromatid segregation (GO:0000819)2.79560656
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.78652697
75NLS-bearing protein import into nucleus (GO:0006607)2.78132450
76resolution of meiotic recombination intermediates (GO:0000712)2.77430082
77regulation of chromosome segregation (GO:0051983)2.76207412
78spindle assembly involved in mitosis (GO:0090307)2.76136683
79regulation of nucleobase-containing compound transport (GO:0032239)2.75271373
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74134831
81protein localization to chromosome (GO:0034502)2.73157691
82columnar/cuboidal epithelial cell development (GO:0002066)2.72956485
83protein localization to microtubule (GO:0035372)2.70948080
84mitotic spindle checkpoint (GO:0071174)2.70854068
85DNA damage response, signal transduction resulting in transcription (GO:0042772)2.70491119
86regulation of sister chromatid segregation (GO:0033045)2.69917708
87regulation of mitotic sister chromatid separation (GO:0010965)2.69917708
88regulation of mitotic sister chromatid segregation (GO:0033047)2.69917708
89mRNA stabilization (GO:0048255)2.67706535
90RNA stabilization (GO:0043489)2.67706535
91DNA replication-independent nucleosome assembly (GO:0006336)2.66891122
92DNA replication-independent nucleosome organization (GO:0034724)2.66891122
93chromatin assembly or disassembly (GO:0006333)2.65334889
94spindle assembly checkpoint (GO:0071173)2.65217656
95histone mRNA catabolic process (GO:0071044)2.65063379
96histone H3-K9 demethylation (GO:0033169)2.65042788
97histone exchange (GO:0043486)2.64422152
98DNA topological change (GO:0006265)2.63727871
99histone-serine phosphorylation (GO:0035404)2.63462907
100anterior/posterior axis specification, embryo (GO:0008595)2.63209932
101DNA replication checkpoint (GO:0000076)2.62911405
102microtubule depolymerization (GO:0007019)2.62453396
103chromatin assembly (GO:0031497)2.61264014
104mitotic spindle organization (GO:0007052)2.61029437
105mitotic spindle assembly checkpoint (GO:0007094)2.60642092
106regulation of DNA-dependent DNA replication (GO:0090329)2.60180310
107histone H3-K9 methylation (GO:0051567)2.59820551
108negative regulation of chromosome segregation (GO:0051985)2.59015508
109mitotic sister chromatid segregation (GO:0000070)2.58945911
110centriole replication (GO:0007099)2.58828655
111spermatid nucleus differentiation (GO:0007289)2.58563609
112regulation of hippo signaling (GO:0035330)2.57653281
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57554641
114negative regulation of sister chromatid segregation (GO:0033046)2.57554641
115negative regulation of mitotic sister chromatid separation (GO:2000816)2.57554641
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57554641
117nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.57553108
118gene silencing by RNA (GO:0031047)2.56577487
119ribosomal large subunit biogenesis (GO:0042273)2.56408435
120ATP-dependent chromatin remodeling (GO:0043044)2.56388675
121negative regulation of cell aging (GO:0090344)2.55135723
122mRNA transport (GO:0051028)2.54559147
123DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54435095
124chromosome segregation (GO:0007059)2.53885629
125cytoskeleton-dependent cytokinesis (GO:0061640)2.53589593
126negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.52002627
127regulation of double-strand break repair via homologous recombination (GO:0010569)2.51608337
128histone H3-K4 methylation (GO:0051568)2.50414131
129chromatin remodeling at centromere (GO:0031055)2.50260144
130histone monoubiquitination (GO:0010390)2.50255760
131dopaminergic neuron differentiation (GO:0071542)2.50092278
132negative regulation of gene silencing (GO:0060969)2.49908915
133DNA duplex unwinding (GO:0032508)2.49835523
134replicative senescence (GO:0090399)2.48999441
135microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.45666855
136neuron fate determination (GO:0048664)2.45171638
137embryonic foregut morphogenesis (GO:0048617)2.45143298
138regulation of growth hormone secretion (GO:0060123)2.41401908
139chromosome condensation (GO:0030261)2.40653991
140DNA packaging (GO:0006323)2.38659378
141ectodermal placode formation (GO:0060788)2.37269574
142N-terminal protein amino acid modification (GO:0031365)2.35114509
143meiotic cell cycle process (GO:1903046)2.34656373
144cytoplasmic mRNA processing body assembly (GO:0033962)2.34487883
145translational termination (GO:0006415)2.33849840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.44913733
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.36857781
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.09434608
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.88108200
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82424326
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56914072
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.42166753
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.31769996
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.03370088
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.97462771
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.86899826
12AR_21909140_ChIP-Seq_LNCAP_Human2.48685652
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15750649
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12613347
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.06920884
16* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98963141
17PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.98799516
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91353149
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83259938
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.81085042
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75963583
22TAF15_26573619_Chip-Seq_HEK293_Human1.75803707
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65743250
24* CBX2_27304074_Chip-Seq_ESCs_Mouse1.63253107
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60047758
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57968895
27* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56072746
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53251949
29PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52230926
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52152925
31SOX2_16153702_ChIP-ChIP_HESCs_Human1.50049955
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.49605824
33FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.49315748
34IGF1R_20145208_ChIP-Seq_DFB_Human1.49077114
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47755437
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45973597
37* KDM5A_27292631_Chip-Seq_BREAST_Human1.45320617
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43582496
39GATA1_22025678_ChIP-Seq_K562_Human1.42916309
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42187860
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40249539
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38959665
43* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38725665
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37992174
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36412235
46* RNF2_27304074_Chip-Seq_NSC_Mouse1.31978638
47* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.30294159
48MYC_22102868_ChIP-Seq_BL_Human1.30064331
49CIITA_25753668_ChIP-Seq_RAJI_Human1.29593228
50* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27865351
51VDR_23849224_ChIP-Seq_CD4+_Human1.27687558
52P300_19829295_ChIP-Seq_ESCs_Human1.26635881
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.24225728
54TTF2_22483619_ChIP-Seq_HELA_Human1.23057942
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22524388
56* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.22367606
57TFEB_21752829_ChIP-Seq_HELA_Human1.22228472
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21889671
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17753483
60ELK1_19687146_ChIP-ChIP_HELA_Human1.16389361
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16220178
62EWS_26573619_Chip-Seq_HEK293_Human1.16136303
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14436897
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13766304
65* CHD1_26751641_Chip-Seq_LNCaP_Human1.13416504
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13068810
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12298130
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11215569
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09482083
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07000215
71BRD4_25478319_ChIP-Seq_HGPS_Human1.05904154
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.03525638
73FOXP3_21729870_ChIP-Seq_TREG_Human1.03486651
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03009489
75GABP_19822575_ChIP-Seq_HepG2_Human1.02471825
76VDR_22108803_ChIP-Seq_LS180_Human1.01517760
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01432204
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00977451
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00755845
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.00580325
81* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99604226
82* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99227762
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98914632
84SMAD3_21741376_ChIP-Seq_EPCs_Human0.97669693
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97312226
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96591289
87FLI1_27457419_Chip-Seq_LIVER_Mouse0.96023237
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95482941
89NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94743993
90* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93566973
91ZNF274_21170338_ChIP-Seq_K562_Hela0.93152137
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92823490
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92220493
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92107610
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92107610
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91377624
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91220214
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90990043
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.90731862
100GF1B_26923725_Chip-Seq_HPCs_Mouse0.90554033
101DCP1A_22483619_ChIP-Seq_HELA_Human0.90102571
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89601700
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89571439
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89262887
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89232151
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89076623
107SOX9_26525672_Chip-Seq_HEART_Mouse0.88507205
108GATA1_26923725_Chip-Seq_HPCs_Mouse0.88143093
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87968411
110GATA6_25053715_ChIP-Seq_YYC3_Human0.87793813
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.86577391
112ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86365123
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.85352190
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85302182
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85059994
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84967492
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84905373
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84802155
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84792359
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84618496
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84212069
122TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83868072
123EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83836642
124KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83076866
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82253096
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81791885
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.80997731
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.80692073
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78819845
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78619164
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76641714
132* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76309556
133* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76237257
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76222501
135FUS_26573619_Chip-Seq_HEK293_Human0.75641642
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75014327
137* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.74162449
138TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73585150
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73512766
140MYC_18940864_ChIP-ChIP_HL60_Human0.73283117
141FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72056832
142GATA4_25053715_ChIP-Seq_YYC3_Human0.72033160
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.71546247
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70735009
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.70610664
146* UBF1/2_26484160_Chip-Seq_HMECs_Human0.69603730
147* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.69102556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.60709536
2MP0003111_abnormal_nucleus_morphology3.09802836
3MP0008789_abnormal_olfactory_epithelium2.74817006
4MP0005394_taste/olfaction_phenotype2.72252262
5MP0005499_abnormal_olfactory_system2.72252262
6MP0010094_abnormal_chromosome_stability2.60581640
7MP0003077_abnormal_cell_cycle2.55523058
8MP0002877_abnormal_melanocyte_morpholog2.55364364
9MP0004957_abnormal_blastocyst_morpholog2.36363763
10MP0003890_abnormal_embryonic-extraembry2.29385212
11MP0003123_paternal_imprinting2.24084267
12MP0008057_abnormal_DNA_replication2.22644040
13MP0003121_genomic_imprinting2.18923374
14MP0004264_abnormal_extraembryonic_tissu2.18151853
15MP0008058_abnormal_DNA_repair2.07836480
16MP0005076_abnormal_cell_differentiation2.04613928
17MP0000569_abnormal_digit_pigmentation1.90710992
18MP0010307_abnormal_tumor_latency1.89802790
19MP0003787_abnormal_imprinting1.80668649
20MP0008007_abnormal_cellular_replicative1.77943803
21MP0010234_abnormal_vibrissa_follicle1.76510084
22MP0008877_abnormal_DNA_methylation1.72112446
23MP0002138_abnormal_hepatobiliary_system1.71672991
24MP0003252_abnormal_bile_duct1.69019969
25MP0010352_gastrointestinal_tract_polyps1.64538234
26MP0002233_abnormal_nose_morphology1.62223153
27MP0002234_abnormal_pharynx_morphology1.61844454
28MP0000778_abnormal_nervous_system1.61686198
29MP0006292_abnormal_olfactory_placode1.60160606
30MP0005220_abnormal_exocrine_pancreas1.59332356
31* MP0001672_abnormal_embryogenesis/_devel1.56707916
32* MP0005380_embryogenesis_phenotype1.56707916
33MP0001730_embryonic_growth_arrest1.56634545
34MP0002139_abnormal_hepatobiliary_system1.53767960
35MP0005365_abnormal_bile_salt1.52990364
36MP0009053_abnormal_anal_canal1.51034304
37MP0009672_abnormal_birth_weight1.49431744
38MP0000566_synostosis1.48325278
39MP0000350_abnormal_cell_proliferation1.47604287
40MP0008995_early_reproductive_senescence1.44380565
41MP0009703_decreased_birth_body1.42791982
42MP0003984_embryonic_growth_retardation1.40885811
43MP0002088_abnormal_embryonic_growth/wei1.40166252
44MP0004197_abnormal_fetal_growth/weight/1.40059484
45MP0003937_abnormal_limbs/digits/tail_de1.40010998
46MP0005451_abnormal_body_composition1.39884561
47MP0010030_abnormal_orbit_morphology1.39848467
48MP0002086_abnormal_extraembryonic_tissu1.38829903
49MP0002084_abnormal_developmental_patter1.38425252
50MP0003861_abnormal_nervous_system1.37828718
51MP0002085_abnormal_embryonic_tissue1.33619311
52MP0003119_abnormal_digestive_system1.31410958
53MP0009379_abnormal_foot_pigmentation1.31029229
54MP0002160_abnormal_reproductive_system1.30511629
55MP0005257_abnormal_intraocular_pressure1.30058906
56MP0001697_abnormal_embryo_size1.30035493
57MP0003567_abnormal_fetal_cardiomyocyte1.27919025
58MP0003868_abnormal_feces_composition1.25612882
59MP0002837_dystrophic_cardiac_calcinosis1.23904761
60MP0002009_preneoplasia1.22910468
61MP0001944_abnormal_pancreas_morphology1.22274570
62MP0000678_abnormal_parathyroid_gland1.22211870
63MP0003705_abnormal_hypodermis_morpholog1.21513743
64MP0010678_abnormal_skin_adnexa1.20301422
65MP0003385_abnormal_body_wall1.18678383
66MP0005248_abnormal_Harderian_gland1.18022375
67MP0003122_maternal_imprinting1.17938097
68MP0000490_abnormal_crypts_of1.17646818
69MP0000383_abnormal_hair_follicle1.17255298
70MP0008932_abnormal_embryonic_tissue1.16435018
71MP0003315_abnormal_perineum_morphology1.15144888
72MP0001286_abnormal_eye_development1.14880586
73MP0003718_maternal_effect1.14683364
74MP0000462_abnormal_digestive_system1.14503898
75MP0003935_abnormal_craniofacial_develop1.13698453
76MP0002928_abnormal_bile_duct1.11983054
77MP0001849_ear_inflammation1.11447426
78MP0003942_abnormal_urinary_system1.10220064
79MP0002693_abnormal_pancreas_physiology1.09302836
80MP0002751_abnormal_autonomic_nervous1.09016693
81MP0000432_abnormal_head_morphology1.08199924
82MP0000537_abnormal_urethra_morphology1.07880428
83MP0000631_abnormal_neuroendocrine_gland1.07188058
84MP0003136_yellow_coat_color1.05540399
85MP0001929_abnormal_gametogenesis1.02638608
86MP0001293_anophthalmia1.02591591
87MP0002822_catalepsy1.00646066
88MP0003755_abnormal_palate_morphology1.00408924
89MP0001299_abnormal_eye_distance/1.00182469
90* MP0002080_prenatal_lethality0.99962578
91MP0000428_abnormal_craniofacial_morphol0.99266190
92MP0001915_intracranial_hemorrhage0.98452491
93MP0001119_abnormal_female_reproductive0.97627242
94MP0004808_abnormal_hematopoietic_stem0.95899025
95MP0000955_abnormal_spinal_cord0.95883584
96MP0001145_abnormal_male_reproductive0.93702869
97MP0002163_abnormal_gland_morphology0.93494053
98MP0004185_abnormal_adipocyte_glucose0.93209810
99MP0003115_abnormal_respiratory_system0.92916837
100MP0003786_premature_aging0.92126134
101MP0005391_vision/eye_phenotype0.91505817
102MP0000647_abnormal_sebaceous_gland0.91347354
103MP0003941_abnormal_skin_development0.91246323
104MP0001984_abnormal_olfaction0.90734330
105MP0001529_abnormal_vocalization0.90367583
106MP0002697_abnormal_eye_size0.89855574
107MP0002184_abnormal_innervation0.87974071
108MP0009250_abnormal_appendicular_skeleto0.87860817
109MP0002081_perinatal_lethality0.85731250
110MP0000427_abnormal_hair_cycle0.84846639
111MP0006054_spinal_hemorrhage0.84298603
112MP0003938_abnormal_ear_development0.83582040
113MP0002092_abnormal_eye_morphology0.82986795
114MP0005085_abnormal_gallbladder_physiolo0.82975447
115MP0005367_renal/urinary_system_phenotyp0.82491087
116MP0000516_abnormal_urinary_system0.82491087
117MP0001340_abnormal_eyelid_morphology0.80860278
118MP0002102_abnormal_ear_morphology0.79860457
119MP0003283_abnormal_digestive_organ0.79747204
120MP0002396_abnormal_hematopoietic_system0.79175848
121MP0005187_abnormal_penis_morphology0.78976639
122MP0000613_abnormal_salivary_gland0.77656390
123MP0002938_white_spotting0.76683443
124MP0005395_other_phenotype0.76637326
125MP0002116_abnormal_craniofacial_bone0.76181351
126MP0000627_abnormal_mammary_gland0.75400568
127MP0009697_abnormal_copulation0.74279366
128MP0002210_abnormal_sex_determination0.73568005
129MP0001186_pigmentation_phenotype0.71158594
130MP0002111_abnormal_tail_morphology0.67997099
131MP0002019_abnormal_tumor_incidence0.67967215
132MP0004782_abnormal_surfactant_physiolog0.66855869
133MP0000653_abnormal_sex_gland0.66747508
134MP0005379_endocrine/exocrine_gland_phen0.66712728
135MP0000313_abnormal_cell_death0.66239461

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.02119487
2Volvulus (HP:0002580)3.94000745
3Chromsome breakage (HP:0040012)3.71341673
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67866529
5Nephroblastoma (Wilms tumor) (HP:0002667)3.07223118
6Cortical dysplasia (HP:0002539)2.98605515
7Embryonal renal neoplasm (HP:0011794)2.91107218
8Ectopic kidney (HP:0000086)2.87927746
9Hepatoblastoma (HP:0002884)2.80971687
10Insidious onset (HP:0003587)2.77746715
11Termporal pattern (HP:0011008)2.77746715
12Abnormal lung lobation (HP:0002101)2.76244884
13Diastasis recti (HP:0001540)2.72250001
14Intestinal atresia (HP:0011100)2.72163408
15Hyperglycemia (HP:0003074)2.70982793
16Papillary thyroid carcinoma (HP:0002895)2.62233973
17High anterior hairline (HP:0009890)2.58876816
18Subacute progressive viral hepatitis (HP:0006572)2.57769091
19Myelomeningocele (HP:0002475)2.56812295
20Abnormality of chromosome stability (HP:0003220)2.55276680
21Deviation of the thumb (HP:0009603)2.52337577
22Impulsivity (HP:0100710)2.51557269
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51309082
24Birth length less than 3rd percentile (HP:0003561)2.51289045
25Long eyelashes (HP:0000527)2.47065210
26Hypoplastic labia majora (HP:0000059)2.44630471
27Proximal placement of thumb (HP:0009623)2.42561724
28Maternal diabetes (HP:0009800)2.36485646
29Anal stenosis (HP:0002025)2.33463981
30Abnormal biliary tract morphology (HP:0012440)2.28639276
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.26773437
32Facial hemangioma (HP:0000329)2.24275237
33Impaired vibration sensation in the lower limbs (HP:0002166)2.23807346
34Chronic hepatic failure (HP:0100626)2.23097012
35Lip pit (HP:0100267)2.21689308
36Embryonal neoplasm (HP:0002898)2.21232420
37Septo-optic dysplasia (HP:0100842)2.20961309
38Deep philtrum (HP:0002002)2.17867968
39Abnormality of the labia majora (HP:0012881)2.17751820
40Biliary tract neoplasm (HP:0100574)2.17487925
41Truncal obesity (HP:0001956)2.13656742
42Gastrointestinal carcinoma (HP:0002672)2.12182360
43Malignant gastrointestinal tract tumors (HP:0006749)2.12182360
44Patellar aplasia (HP:0006443)2.11170536
45Drooling (HP:0002307)2.09884805
46Abnormality of the corticospinal tract (HP:0002492)2.09685272
47Meckel diverticulum (HP:0002245)2.09329009
48Asymmetry of the thorax (HP:0001555)2.09129455
49Increased nuchal translucency (HP:0010880)2.08785658
50Abnormality of the nasal septum (HP:0000419)2.08064783
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.08005156
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08005156
53Abnormality of the intrinsic pathway (HP:0010989)2.05209075
54Hypoglycemic seizures (HP:0002173)2.04909146
55Prominent nose (HP:0000448)2.04836366
56Missing ribs (HP:0000921)2.04267497
57Anophthalmia (HP:0000528)2.03309658
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.00666965
59Hyperinsulinemic hypoglycemia (HP:0000825)2.00243962
60Oligodactyly (hands) (HP:0001180)1.98932246
61Medulloblastoma (HP:0002885)1.98396829
62Optic nerve coloboma (HP:0000588)1.98136709
63Thyroid carcinoma (HP:0002890)1.97146789
64Transitional cell carcinoma of the bladder (HP:0006740)1.96681229
65Neoplasm of the adrenal cortex (HP:0100641)1.96518822
66Capillary hemangiomas (HP:0005306)1.96474650
67Urethral obstruction (HP:0000796)1.94007958
68Osteomalacia (HP:0002749)1.92432705
69Labial hypoplasia (HP:0000066)1.92277820
70Abnormal pancreas size (HP:0012094)1.91127279
71Aplasia/Hypoplasia of the patella (HP:0006498)1.90597779
72Shawl scrotum (HP:0000049)1.89232012
73Hypochromic microcytic anemia (HP:0004840)1.88639622
74Overlapping toe (HP:0001845)1.88503618
75Multiple enchondromatosis (HP:0005701)1.88134711
76Hypoplastic female external genitalia (HP:0012815)1.87855568
77Abnormality of the carotid arteries (HP:0005344)1.87460952
78Acute myeloid leukemia (HP:0004808)1.87284119
79Abnormality of the preputium (HP:0100587)1.86418103
80Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86058568
81Abnormality of chromosome segregation (HP:0002916)1.85880339
82Oligodactyly (HP:0012165)1.85810359
83Short 4th metacarpal (HP:0010044)1.85585782
84Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85585782
85Esophageal atresia (HP:0002032)1.85535636
86Rhabdomyosarcoma (HP:0002859)1.84643513
87Hypoglycemic coma (HP:0001325)1.83928460
88Hypoplastic pelvis (HP:0008839)1.83903677
89Curly hair (HP:0002212)1.83731349
90Abnormality of the ileum (HP:0001549)1.82787157
91Myelodysplasia (HP:0002863)1.82170331
92Neoplasm of striated muscle (HP:0009728)1.81471514
93Scotoma (HP:0000575)1.81331368
94Bladder carcinoma (HP:0002862)1.81018210
95Bladder neoplasm (HP:0009725)1.81018210
96Midline defect of the nose (HP:0004122)1.79310523
97Excessive salivation (HP:0003781)1.78831940
98Uterine neoplasm (HP:0010784)1.77919295
99Abnormal number of incisors (HP:0011064)1.77852997
100Short middle phalanx of the 5th finger (HP:0004220)1.77764233
101Double outlet right ventricle (HP:0001719)1.77754250
102Congenital malformation of the right heart (HP:0011723)1.77754250
103Insulin-resistant diabetes mellitus (HP:0000831)1.76498268
104Gastrointestinal atresia (HP:0002589)1.75587377
105Absent radius (HP:0003974)1.75527119
106Facial cleft (HP:0002006)1.74293568
107Bilateral microphthalmos (HP:0007633)1.73991848
108Abnormality of the astrocytes (HP:0100707)1.73517859
109Astrocytoma (HP:0009592)1.73517859
110Leiomyosarcoma (HP:0100243)1.72875208
111Uterine leiomyosarcoma (HP:0002891)1.72875208
112Intellectual disability, moderate (HP:0002342)1.71707022
113Abnormality of pyrimidine metabolism (HP:0004353)1.71404607
114Abnormality of the intervertebral disk (HP:0005108)1.71266619
115Bifid tongue (HP:0010297)1.71262418
116Ureteral duplication (HP:0000073)1.71213451
117Abnormality of abdominal situs (HP:0011620)1.70757131
118Abdominal situs inversus (HP:0003363)1.70757131
119Abnormality of the septum pellucidum (HP:0007375)1.69351619
120Horizontal nystagmus (HP:0000666)1.68557148
121Gonadotropin excess (HP:0000837)1.67931101
122Unilateral renal agenesis (HP:0000122)1.67265308
123Small intestinal stenosis (HP:0012848)1.67178390
124Duodenal stenosis (HP:0100867)1.67178390
125Breast carcinoma (HP:0003002)1.66883239
126Cafe-au-lait spot (HP:0000957)1.66483798
12711 pairs of ribs (HP:0000878)1.66226694
128Central scotoma (HP:0000603)1.65237132
129Absent eyebrow (HP:0002223)1.64890775
130Triphalangeal thumb (HP:0001199)1.64770387
131Partial agenesis of the corpus callosum (HP:0001338)1.64509474
132Increased number of teeth (HP:0011069)1.64436485
133Neoplasm of the oral cavity (HP:0100649)1.64089379
134Abnormality of the labia minora (HP:0012880)1.63442031
135Glioma (HP:0009733)1.63328442
136Abnormality of the duodenum (HP:0002246)1.62404894
137Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.62378146
138Renal cortical cysts (HP:0000803)1.61610184
139Supernumerary spleens (HP:0009799)1.61492461
140Shoulder girdle muscle weakness (HP:0003547)1.61451514
141Arteriovenous malformation (HP:0100026)1.61101890
142Rectal prolapse (HP:0002035)1.60699244
143Breast hypoplasia (HP:0003187)1.60679705
144Neoplasm of the tracheobronchial system (HP:0100552)1.59827891
145Skull defect (HP:0001362)1.58719151
146Ependymoma (HP:0002888)1.58557190
147Entropion (HP:0000621)1.58455638
148Aplasia involving forearm bones (HP:0009822)1.58105918
149Absent forearm bone (HP:0003953)1.58105918
150Blepharitis (HP:0000498)1.57928038
151Limb hypertonia (HP:0002509)1.56744733
152Atresia of the external auditory canal (HP:0000413)1.56722241
153Clubbing of toes (HP:0100760)1.56428090
154Heterotopia (HP:0002282)1.55651612
155Neoplasm of the colon (HP:0100273)1.55004335
156Broad thumb (HP:0011304)1.54430817
157Symptomatic seizures (HP:0011145)1.54263431
158Duplicated collecting system (HP:0000081)1.53309931
159Low anterior hairline (HP:0000294)1.53285814
160Viral hepatitis (HP:0006562)1.53226607
161Abnormality of DNA repair (HP:0003254)1.52889856
162Horseshoe kidney (HP:0000085)1.52489435
163Macroorchidism (HP:0000053)1.51938129
164Cystic liver disease (HP:0006706)1.51875603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.85720621
2PNCK4.05481598
3CDK123.77799242
4STK38L3.24523684
5CDC72.94049498
6CASK2.79995557
7NEK22.53186725
8BUB12.38564506
9FRK2.37794540
10EEF2K2.27679300
11TAOK32.18925486
12SRPK12.11495197
13STK32.09619784
14NUAK12.08514459
15TTK2.00696925
16MKNK21.92291249
17EIF2AK11.89024885
18MAP3K41.86008035
19ZAK1.83502407
20TSSK61.78270256
21NEK91.76655361
22CDK81.73319081
23RPS6KA41.69961804
24PASK1.67909756
25STK391.65975868
26PRKD31.65691889
27BRD41.63031700
28PBK1.59740603
29MET1.58751691
30BRSK11.58045875
31INSRR1.54836589
32PLK41.54636596
33CDK91.49474969
34CHEK21.49190982
35CDK61.48634518
36ACVR1B1.48456200
37KSR11.47118114
38MKNK11.39766654
39TNIK1.35673165
40CDK41.34103884
41LATS21.33335986
42IRAK31.30511992
43CAMK1D1.26320018
44PLK31.26224982
45DYRK31.22404815
46ATM1.22091365
47CHEK11.20386994
48MELK1.19823833
49AURKB1.19333479
50MARK11.18814242
51BRSK21.17609563
52MAP3K101.17012564
53MAP3K21.16836221
54AKT31.16296599
55CDK71.14858785
56ATR1.14842713
57PLK11.09734800
58TAF11.08807564
59PTK61.05581935
60MTOR1.02629240
61MAPKAPK30.98923531
62SGK20.97678339
63TYRO30.95590512
64BCR0.92722165
65MAP3K90.92517029
66CDK30.91611650
67EPHA20.91539951
68KSR20.91297417
69JAK30.87824643
70CHUK0.87231696
71CAMK1G0.85406812
72EPHB20.85197137
73WNK40.83718227
74MAP3K60.83433415
75ERBB40.81959682
76WNK10.77415720
77TRPM70.76588440
78NLK0.76564250
79TRIM280.75900591
80CDK20.74781739
81PIM10.74567157
82FLT30.72837752
83MAP2K10.72520523
84PDGFRA0.71921107
85SGK30.70454682
86WEE10.70352247
87HIPK20.67060142
88DYRK20.66660661
89DYRK1A0.66652383
90RPS6KB20.65856611
91NEK10.65511840
92FGFR10.62694853
93PRKAA20.62645343
94MAP3K30.60711465
95FGFR20.60497419
96CDK10.60296766
97RPS6KB10.59450374
98STK40.59385649
99CDK190.59043356
100PRKCI0.58473489
101SGK4940.58436867
102SGK2230.58436867
103FGFR30.57891222
104ICK0.57811416
105PDGFRB0.57612737
106MAP3K80.57431601
107PLK20.56995949
108ERBB30.56568844
109AURKA0.55277703
110OXSR10.54391971
111MAPK140.54260807
112PRKAA10.53912263
113EIF2AK30.53384113
114AKT10.52448150
115STK100.51972784
116WNK30.51798461
117RAF10.51165486
118PRKDC0.50777173
119CSNK1G10.50613474
120BRAF0.50081310
121MAPK110.49925538
122ALK0.49298384
123EIF2AK20.48611561
124RPS6KA50.48526175
125TAOK20.48430556
126CSNK1A1L0.47487454
127YES10.45980493
128MAP3K50.45553127
129PKN20.45416501
130CDC42BPA0.45415074
131PIK3CG0.44407705
132STK240.41724396
133MINK10.41107771
134MAP3K140.40217843
135CSNK1E0.40105965
136MST1R0.39889126
137AKT20.39156470
138CSNK1D0.38988446
139MAPK130.38414300
140GSK3B0.37740049
141NTRK30.37178618
142LRRK20.36892636
143STK110.36818926
144CSNK2A20.36124730
145PRKCZ0.35745627

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.98209315
2Cell cycle_Homo sapiens_hsa041102.84240553
3One carbon pool by folate_Homo sapiens_hsa006702.69008533
4RNA transport_Homo sapiens_hsa030132.50981455
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50527919
6Fanconi anemia pathway_Homo sapiens_hsa034602.25797457
7Lysine degradation_Homo sapiens_hsa003102.23524828
8mRNA surveillance pathway_Homo sapiens_hsa030152.16678646
9Basal transcription factors_Homo sapiens_hsa030222.10199776
10Ribosome_Homo sapiens_hsa030102.09579381
11Non-homologous end-joining_Homo sapiens_hsa034501.94637179
12Mismatch repair_Homo sapiens_hsa034301.87575907
13Vitamin B6 metabolism_Homo sapiens_hsa007501.86388496
14Selenocompound metabolism_Homo sapiens_hsa004501.85145201
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80993916
16RNA degradation_Homo sapiens_hsa030181.70198415
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.68821823
18p53 signaling pathway_Homo sapiens_hsa041151.68034883
19Spliceosome_Homo sapiens_hsa030401.67915981
20Steroid biosynthesis_Homo sapiens_hsa001001.67467523
21RNA polymerase_Homo sapiens_hsa030201.67032070
22MicroRNAs in cancer_Homo sapiens_hsa052061.50424086
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48959255
24Homologous recombination_Homo sapiens_hsa034401.48666703
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41955688
26Nucleotide excision repair_Homo sapiens_hsa034201.40635572
27Adherens junction_Homo sapiens_hsa045201.40573351
28DNA replication_Homo sapiens_hsa030301.40365292
29Prostate cancer_Homo sapiens_hsa052151.36944447
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33158504
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30586710
32TGF-beta signaling pathway_Homo sapiens_hsa043501.29819344
33Base excision repair_Homo sapiens_hsa034101.27874282
34Circadian rhythm_Homo sapiens_hsa047101.25294906
35Small cell lung cancer_Homo sapiens_hsa052221.24370755
36Axon guidance_Homo sapiens_hsa043601.23213694
37ErbB signaling pathway_Homo sapiens_hsa040121.20456172
38Herpes simplex infection_Homo sapiens_hsa051681.20432599
39Endometrial cancer_Homo sapiens_hsa052131.18701287
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14974111
41Propanoate metabolism_Homo sapiens_hsa006401.11463631
42Thyroid cancer_Homo sapiens_hsa052161.11185510
43Basal cell carcinoma_Homo sapiens_hsa052171.10206796
44Hippo signaling pathway_Homo sapiens_hsa043901.05259867
45Chronic myeloid leukemia_Homo sapiens_hsa052201.02268254
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01461850
47mTOR signaling pathway_Homo sapiens_hsa041501.00783919
48Pyrimidine metabolism_Homo sapiens_hsa002400.99781540
49Pyruvate metabolism_Homo sapiens_hsa006200.99189717
50Protein export_Homo sapiens_hsa030600.97457673
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.97101461
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.96699301
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96059323
54FoxO signaling pathway_Homo sapiens_hsa040680.95140161
55Vitamin digestion and absorption_Homo sapiens_hsa049770.94402544
56Viral carcinogenesis_Homo sapiens_hsa052030.92641359
57Tight junction_Homo sapiens_hsa045300.91463354
58HTLV-I infection_Homo sapiens_hsa051660.91026657
59Melanogenesis_Homo sapiens_hsa049160.89558139
60Renal cell carcinoma_Homo sapiens_hsa052110.89394723
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89102815
62Bladder cancer_Homo sapiens_hsa052190.88934637
63Insulin resistance_Homo sapiens_hsa049310.88235511
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.85899032
65Alcoholism_Homo sapiens_hsa050340.83178751
66Pancreatic cancer_Homo sapiens_hsa052120.82140352
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82094544
68Prolactin signaling pathway_Homo sapiens_hsa049170.76444482
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74605616
70Colorectal cancer_Homo sapiens_hsa052100.73559506
71Fatty acid biosynthesis_Homo sapiens_hsa000610.73181518
72VEGF signaling pathway_Homo sapiens_hsa043700.70484318
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69526170
74Autoimmune thyroid disease_Homo sapiens_hsa053200.68647421
75Systemic lupus erythematosus_Homo sapiens_hsa053220.67573006
76Non-small cell lung cancer_Homo sapiens_hsa052230.67470182
77Glioma_Homo sapiens_hsa052140.65797987
78Antigen processing and presentation_Homo sapiens_hsa046120.62902985
79Tryptophan metabolism_Homo sapiens_hsa003800.62564515
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.62464125
81Hedgehog signaling pathway_Homo sapiens_hsa043400.62417519
82Nicotine addiction_Homo sapiens_hsa050330.62160467
83Hepatitis B_Homo sapiens_hsa051610.60922344
84Epstein-Barr virus infection_Homo sapiens_hsa051690.60130714
85Wnt signaling pathway_Homo sapiens_hsa043100.58797911
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58652183
87Dorso-ventral axis formation_Homo sapiens_hsa043200.58231623
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57770387
89Thyroid hormone synthesis_Homo sapiens_hsa049180.57677681
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57452392
91Melanoma_Homo sapiens_hsa052180.57157636
92Type II diabetes mellitus_Homo sapiens_hsa049300.55960962
93Cocaine addiction_Homo sapiens_hsa050300.55812533
94Folate biosynthesis_Homo sapiens_hsa007900.55288590
95Choline metabolism in cancer_Homo sapiens_hsa052310.54560216
96Dopaminergic synapse_Homo sapiens_hsa047280.54017136
97AMPK signaling pathway_Homo sapiens_hsa041520.53852088
98Glucagon signaling pathway_Homo sapiens_hsa049220.53608186
99Pathways in cancer_Homo sapiens_hsa052000.52826868
100Acute myeloid leukemia_Homo sapiens_hsa052210.52468667
101Inositol phosphate metabolism_Homo sapiens_hsa005620.51867784
102Regulation of autophagy_Homo sapiens_hsa041400.50094463
103Measles_Homo sapiens_hsa051620.49181443
104Gap junction_Homo sapiens_hsa045400.48450628
105Purine metabolism_Homo sapiens_hsa002300.47254677
106Notch signaling pathway_Homo sapiens_hsa043300.46707237
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46506776
108Sulfur metabolism_Homo sapiens_hsa009200.45641243
109ABC transporters_Homo sapiens_hsa020100.45565274
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45558687
111Amphetamine addiction_Homo sapiens_hsa050310.45495397
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45416050
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44632919
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.43343190
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42520538
116Oocyte meiosis_Homo sapiens_hsa041140.41729708
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41642941
118Taste transduction_Homo sapiens_hsa047420.39967557
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38894711
120Insulin signaling pathway_Homo sapiens_hsa049100.38484278
121Proteoglycans in cancer_Homo sapiens_hsa052050.38128116
122Complement and coagulation cascades_Homo sapiens_hsa046100.37384177
123Carbon metabolism_Homo sapiens_hsa012000.37226451
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36355794
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36222227
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.35385450
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.34907797
128Fat digestion and absorption_Homo sapiens_hsa049750.33441914
129Influenza A_Homo sapiens_hsa051640.32109458
130Estrogen signaling pathway_Homo sapiens_hsa049150.31719845
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31348131
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31334657
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31085817
134N-Glycan biosynthesis_Homo sapiens_hsa005100.27807905
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.26737213
136Apoptosis_Homo sapiens_hsa042100.25894280

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