CDK17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.62826785
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.40306451
3locomotory exploration behavior (GO:0035641)5.31975315
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30790724
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.17419606
6synaptic vesicle maturation (GO:0016188)5.14520793
7vocalization behavior (GO:0071625)5.10290956
8regulation of glutamate receptor signaling pathway (GO:1900449)4.99796030
9synaptic vesicle exocytosis (GO:0016079)4.87622450
10regulation of long-term neuronal synaptic plasticity (GO:0048169)4.83120058
11glutamate secretion (GO:0014047)4.61063371
12glutamate receptor signaling pathway (GO:0007215)4.60085843
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.51806117
14protein localization to synapse (GO:0035418)4.49655376
15regulation of synaptic vesicle exocytosis (GO:2000300)4.46405618
16regulation of neuronal synaptic plasticity (GO:0048168)4.45762014
17regulation of synapse structural plasticity (GO:0051823)4.44802564
18synaptic transmission, glutamatergic (GO:0035249)4.40759879
19neuron cell-cell adhesion (GO:0007158)4.38190472
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.31609118
21exploration behavior (GO:0035640)4.30112127
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.29210491
23neuron-neuron synaptic transmission (GO:0007270)4.24138682
24regulation of dendritic spine morphogenesis (GO:0061001)4.23712787
25neuronal action potential propagation (GO:0019227)4.22045811
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19387654
27negative regulation of cell killing (GO:0031342)4.19387654
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.15458085
29endothelium development (GO:0003158)4.14207413
30regulation of synaptic vesicle transport (GO:1902803)4.01450280
31G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.00053765
32long-term memory (GO:0007616)3.97342773
33Notch signaling involved in heart development (GO:0061314)3.96796111
34blood vessel maturation (GO:0001955)3.89131963
35regulation of postsynaptic membrane potential (GO:0060078)3.85197481
36regulation of synaptic plasticity (GO:0048167)3.81901999
37long-term synaptic potentiation (GO:0060291)3.80492020
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.79673063
39neurotransmitter-gated ion channel clustering (GO:0072578)3.75883271
40positive regulation of membrane potential (GO:0045838)3.75098584
41neurotransmitter secretion (GO:0007269)3.74836580
42positive regulation of neurotransmitter secretion (GO:0001956)3.69998147
43regulation of dendritic spine development (GO:0060998)3.68867695
44dendritic spine morphogenesis (GO:0060997)3.66778226
45layer formation in cerebral cortex (GO:0021819)3.66577889
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56112625
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.55953097
48behavioral fear response (GO:0001662)3.53584102
49behavioral defense response (GO:0002209)3.53584102
50neuron recognition (GO:0008038)3.52928305
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.52768106
52transmission of nerve impulse (GO:0019226)3.52070711
53regulation of glutamate secretion (GO:0014048)3.50501041
54prepulse inhibition (GO:0060134)3.48415097
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48316625
56response to histamine (GO:0034776)3.48256305
57positive regulation of synapse maturation (GO:0090129)3.39885685
58positive regulation of neurotransmitter transport (GO:0051590)3.39684472
59gamma-aminobutyric acid transport (GO:0015812)3.37094999
60cellular potassium ion homeostasis (GO:0030007)3.30588545
61presynaptic membrane assembly (GO:0097105)3.28140922
62neuromuscular process controlling balance (GO:0050885)3.27333183
63synaptic transmission, dopaminergic (GO:0001963)3.26665332
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26645301
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.25469364
66phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.24536079
67learning (GO:0007612)3.23458095
68positive regulation of dendritic spine morphogenesis (GO:0061003)3.22968454
69fear response (GO:0042596)3.22817981
70vesicle transport along microtubule (GO:0047496)3.22115661
71positive regulation of dendritic spine development (GO:0060999)3.20450199
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19484748
73response to amphetamine (GO:0001975)3.18297822
74regulation of vesicle fusion (GO:0031338)3.15841792
75regulation of neurotransmitter secretion (GO:0046928)3.14334354
76activation of protein kinase A activity (GO:0034199)3.12960943
77membrane depolarization (GO:0051899)3.12733486
78axonal fasciculation (GO:0007413)3.11637709
79positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08945548
80behavioral response to cocaine (GO:0048148)3.08532402
81presynaptic membrane organization (GO:0097090)3.07560100
82regulation of Rap GTPase activity (GO:0032317)3.04258466
83nerve growth factor signaling pathway (GO:0038180)3.03046955
84negative regulation of amino acid transport (GO:0051956)3.02603402
85cerebellar Purkinje cell differentiation (GO:0021702)3.02463020
86synaptic vesicle endocytosis (GO:0048488)3.01707654
87regulation of voltage-gated calcium channel activity (GO:1901385)3.01618994
88postsynaptic membrane organization (GO:0001941)3.01566195
89auditory behavior (GO:0031223)3.00968997
90positive regulation of synaptic transmission (GO:0050806)2.97403024
91neurotransmitter transport (GO:0006836)2.96145252
92regulation of neurotransmitter transport (GO:0051588)2.94324802
93sprouting angiogenesis (GO:0002040)2.94122656
94dendritic spine organization (GO:0097061)2.93874793
95morphogenesis of an endothelium (GO:0003159)2.92841210
96endothelial tube morphogenesis (GO:0061154)2.92841210
97regulation of synaptic transmission (GO:0050804)2.90837068
98Rap protein signal transduction (GO:0032486)2.90678533
99visual learning (GO:0008542)2.90652510
100long term synaptic depression (GO:0060292)2.90553435
101regulation of female receptivity (GO:0045924)2.90093349
102dopamine receptor signaling pathway (GO:0007212)2.90031223
103proline transport (GO:0015824)2.88538600
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88420752
105regulation of neurotransmitter levels (GO:0001505)2.85785003
106regulation of synaptic transmission, GABAergic (GO:0032228)2.85332278
107protein localization to endosome (GO:0036010)2.84843992
108mechanosensory behavior (GO:0007638)2.82402359
109adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.81539818
110retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77346758
111positive regulation of fibroblast migration (GO:0010763)2.75088218
112regulation of cAMP-dependent protein kinase activity (GO:2000479)2.72670393
113interkinetic nuclear migration (GO:0022027)2.72203168
114organelle transport along microtubule (GO:0072384)2.68366684
115positive regulation of vasculogenesis (GO:2001214)2.57472613
116negative regulation of dendrite morphogenesis (GO:0050774)2.53628965
117lipid translocation (GO:0034204)2.52748458
118phospholipid translocation (GO:0045332)2.52748458
119cell adhesion mediated by integrin (GO:0033627)2.50089019
120cellular response to ethanol (GO:0071361)2.42780055
121response to nerve growth factor (GO:1990089)2.42367834
122cellular response to nerve growth factor stimulus (GO:1990090)2.42367834
123negative regulation of blood vessel endothelial cell migration (GO:0043537)2.41891952
124establishment of mitochondrion localization (GO:0051654)2.41762560
125regulation of protein polyubiquitination (GO:1902914)2.41568236
126wound healing, spreading of epidermal cells (GO:0035313)2.40687958
127negative regulation of neurotransmitter secretion (GO:0046929)2.39129423
128positive regulation of Rap GTPase activity (GO:0032854)2.37218489
129definitive hemopoiesis (GO:0060216)2.36327199
130neural tube formation (GO:0001841)2.36214438
131positive regulation of T cell cytokine production (GO:0002726)2.34114200
132regulation of clathrin-mediated endocytosis (GO:2000369)2.33784330
133regulation of Rac protein signal transduction (GO:0035020)2.31725883
134positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.31559114
135negative regulation of neurotransmitter transport (GO:0051589)2.28340327
136heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.26901428
137clathrin coat assembly (GO:0048268)2.22107621
138T cell migration (GO:0072678)2.21857250
139protein targeting to vacuole (GO:0006623)2.20870565
140protein targeting to lysosome (GO:0006622)2.20870565
141establishment of protein localization to vacuole (GO:0072666)2.20870565
142protein targeting to Golgi (GO:0000042)2.20338067
143negative regulation of anoikis (GO:2000811)2.19609108
144establishment of nucleus localization (GO:0040023)2.18078239
145lymphangiogenesis (GO:0001946)2.18061959
146central nervous system projection neuron axonogenesis (GO:0021952)2.15588445
147nucleus localization (GO:0051647)2.15512962
148signal complex assembly (GO:0007172)2.15434786
149establishment of protein localization to Golgi (GO:0072600)2.12904095
150regulation of sarcomere organization (GO:0060297)2.12372780
151positive regulation of cardiac muscle cell differentiation (GO:2000727)2.11317509
152mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.10903780
153positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.10903780
154regulation of pigment cell differentiation (GO:0050932)2.08265836
155heart trabecula morphogenesis (GO:0061384)2.07974274
156regulation of chemokine-mediated signaling pathway (GO:0070099)2.07755937
157regulation of establishment of cell polarity (GO:2000114)2.06958549
158interleukin-6-mediated signaling pathway (GO:0070102)2.05735907
159regulation of B cell receptor signaling pathway (GO:0050855)2.04378505
160retrograde transport, vesicle recycling within Golgi (GO:0000301)2.03997557
161embryonic process involved in female pregnancy (GO:0060136)2.03887688
162membrane assembly (GO:0071709)2.02852768
163positive regulation of endothelial cell differentiation (GO:0045603)2.02339255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77354351
2GBX2_23144817_ChIP-Seq_PC3_Human3.71818496
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.08010031
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97374359
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95200455
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80026575
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53246795
8REST_21632747_ChIP-Seq_MESCs_Mouse2.51682740
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41498050
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41498050
11DROSHA_22980978_ChIP-Seq_HELA_Human2.39838592
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36014019
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.35014766
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29793599
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26892803
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26344561
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23292324
18AR_21572438_ChIP-Seq_LNCaP_Human2.18649262
19* TAF15_26573619_Chip-Seq_HEK293_Human2.10455202
20GATA2_21666600_ChIP-Seq_HMVEC_Human2.09321633
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.06979093
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04386974
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03390326
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02384865
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01386884
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.01064996
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95648628
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.93413527
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.88889495
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.87452230
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86341145
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.81101262
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78711152
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.78151396
35SMAD4_21799915_ChIP-Seq_A2780_Human1.75921420
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75762706
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74871505
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.73933725
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72382250
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69894887
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60379260
42* P300_19829295_ChIP-Seq_ESCs_Human1.60306476
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60299897
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60299897
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58417020
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56827936
47* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55355178
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49217943
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47622683
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46651868
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.46004994
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45748689
53ZNF274_21170338_ChIP-Seq_K562_Hela1.44214887
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44157886
55* SMAD3_21741376_ChIP-Seq_EPCs_Human1.42490739
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41378556
57TP53_16413492_ChIP-PET_HCT116_Human1.41178202
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41164052
59* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38210088
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36202820
61FUS_26573619_Chip-Seq_HEK293_Human1.35735164
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35576893
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35509020
64* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33994131
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33295438
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.33022378
67STAT3_23295773_ChIP-Seq_U87_Human1.31788866
68AR_25329375_ChIP-Seq_VCAP_Human1.30939452
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.30812431
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30037304
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30001197
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29944705
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27970812
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27834846
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27518914
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26990793
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26745786
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24414476
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22368287
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22144672
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.22096672
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21155626
83* FLI1_21867929_ChIP-Seq_TH2_Mouse1.20717411
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19980989
85SCL_19346495_ChIP-Seq_HPC-7_Human1.19349508
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18848822
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.17564057
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17066972
89* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16800904
90TCF4_23295773_ChIP-Seq_U87_Human1.16262518
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15454361
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14768276
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14682701
94RUNX_20019798_ChIP-Seq_JUKART_Human1.13829696
95AR_19668381_ChIP-Seq_PC3_Human1.13228430
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.13212793
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12562973
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12392329
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12150830
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11809513
101BRD4_25478319_ChIP-Seq_HGPS_Human1.11732179
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.09468978
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08218645
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07452553
105RXR_22108803_ChIP-Seq_LS180_Human1.07185155
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07084560
107* EZH2_27294783_Chip-Seq_NPCs_Mouse1.06850496
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06609038
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.06373850
110KDM2B_26808549_Chip-Seq_REH_Human1.06203680
111* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06050574
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05738634
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.05536545
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03366076
115VDR_24787735_ChIP-Seq_THP-1_Human1.02926513
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02214391
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02078330
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01704132
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.01639898
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01184487
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00909020
122RING1B_27294783_Chip-Seq_NPCs_Mouse1.00607497
123RUNX2_22187159_ChIP-Seq_PCA_Human1.00143695
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99852598
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99582266
126* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99528770
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99525911
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98889247
129* CJUN_26792858_Chip-Seq_BT549_Human0.98349406
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98042365
131TP53_18474530_ChIP-ChIP_U2OS_Human0.98015217
132CMYC_18555785_Chip-Seq_ESCs_Mouse0.97961104
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.97693025
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97482384
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97320027
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97320027
137RNF2_27304074_Chip-Seq_NSC_Mouse0.97190187
138EWS_26573619_Chip-Seq_HEK293_Human0.96388685
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.96022568
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.95892422
141JUN_21703547_ChIP-Seq_K562_Human0.95736202
142BCAT_22108803_ChIP-Seq_LS180_Human0.95272462
143AHR_22903824_ChIP-Seq_MCF-7_Human0.94674454
144IGF1R_20145208_ChIP-Seq_DFB_Human0.94553554
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.93569445
146ER_23166858_ChIP-Seq_MCF-7_Human0.92445221
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90796885
148* KDM2B_26808549_Chip-Seq_K562_Human0.88950135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.13204060
2MP0003880_abnormal_central_pattern5.77453148
3MP0003635_abnormal_synaptic_transmissio4.36063232
4MP0010368_abnormal_lymphatic_system4.14010805
5MP0002822_catalepsy3.92065716
6MP0009745_abnormal_behavioral_response3.80611340
7MP0002063_abnormal_learning/memory/cond3.59492234
8MP0004270_analgesia3.49653923
9MP0001879_abnormal_lymphatic_vessel3.29777879
10MP0002064_seizures3.20779807
11MP0000465_gastrointestinal_hemorrhage3.10399351
12MP0001968_abnormal_touch/_nociception3.05535496
13MP0002572_abnormal_emotion/affect_behav2.92786841
14MP0003724_increased_susceptibility_to2.83612416
15MP0009046_muscle_twitch2.74907519
16MP0006054_spinal_hemorrhage2.66977628
17MP0001501_abnormal_sleep_pattern2.59018376
18MP0002272_abnormal_nervous_system2.55902862
19MP0005423_abnormal_somatic_nervous2.53590131
20MP0001486_abnormal_startle_reflex2.50498092
21MP0002736_abnormal_nociception_after2.49055841
22MP0003091_abnormal_cell_migration2.15651430
23MP0001440_abnormal_grooming_behavior2.11650157
24MP0002734_abnormal_mechanical_nocicepti2.06921341
25MP0003828_pulmonary_edema2.02490590
26MP0002735_abnormal_chemical_nociception1.96969442
27MP0008569_lethality_at_weaning1.90540453
28MP0003221_abnormal_cardiomyocyte_apopto1.84515729
29MP0004924_abnormal_behavior1.82607840
30MP0005386_behavior/neurological_phenoty1.82607840
31MP0002067_abnormal_sensory_capabilities1.81973469
32MP0003329_amyloid_beta_deposits1.79556256
33MP0002877_abnormal_melanocyte_morpholog1.79117416
34MP0008057_abnormal_DNA_replication1.73420062
35MP0001970_abnormal_pain_threshold1.69472576
36MP0004811_abnormal_neuron_physiology1.68504875
37MP0002557_abnormal_social/conspecific_i1.62440797
38MP0000778_abnormal_nervous_system1.62316243
39MP0002733_abnormal_thermal_nociception1.61667005
40MP0001529_abnormal_vocalization1.61492063
41MP0001188_hyperpigmentation1.61066656
42MP0002009_preneoplasia1.60921469
43MP0004272_abnormal_basement_membrane1.58786116
44MP0002332_abnormal_exercise_endurance1.58450750
45MP0003787_abnormal_imprinting1.58240086
46MP0005646_abnormal_pituitary_gland1.53817185
47MP0005409_darkened_coat_color1.52293950
48MP0002909_abnormal_adrenal_gland1.49981761
49MP0002184_abnormal_innervation1.49377543
50MP0001915_intracranial_hemorrhage1.48265179
51MP0003633_abnormal_nervous_system1.45483579
52MP0004510_myositis1.44438385
53MP0001905_abnormal_dopamine_level1.42439272
54MP0008260_abnormal_autophagy1.38200402
55MP0000767_abnormal_smooth_muscle1.37230752
56MP0004084_abnormal_cardiac_muscle1.34810740
57MP0000955_abnormal_spinal_cord1.33852944
58MP0002066_abnormal_motor_capabilities/c1.30669771
59MP0009780_abnormal_chondrocyte_physiolo1.29530465
60MP0004885_abnormal_endolymph1.29171802
61MP0003279_aneurysm1.26753890
62MP0005187_abnormal_penis_morphology1.24465662
63MP0003879_abnormal_hair_cell1.23720250
64MP0008874_decreased_physiological_sensi1.21737170
65MP0005595_abnormal_vascular_smooth1.19955583
66MP0003631_nervous_system_phenotype1.19705511
67MP0002138_abnormal_hepatobiliary_system1.19510482
68MP0003075_altered_response_to1.18991182
69MP0003045_fibrosis1.16844323
70MP0001984_abnormal_olfaction1.16326658
71MP0002882_abnormal_neuron_morphology1.15825427
72MP0003566_abnormal_cell_adhesion1.13763285
73MP0004858_abnormal_nervous_system1.09770845
74MP0008872_abnormal_physiological_respon1.08807660
75MP0001502_abnormal_circadian_rhythm1.08572968
76MP0000604_amyloidosis1.06116684
77MP0005388_respiratory_system_phenotype1.05672227
78MP0002133_abnormal_respiratory_system1.05672227
79MP0000920_abnormal_myelination1.05252373
80MP0006276_abnormal_autonomic_nervous1.02870081
81MP0002152_abnormal_brain_morphology1.00781046
82MP0001958_emphysema0.98237609
83MP0000569_abnormal_digit_pigmentation0.95147606
84MP0010234_abnormal_vibrissa_follicle0.94263510
85MP0001299_abnormal_eye_distance/0.94212709
86MP0004808_abnormal_hematopoietic_stem0.91952744
87MP0001851_eye_inflammation0.91669976
88MP0005167_abnormal_blood-brain_barrier0.89226274
89MP0005621_abnormal_cell_physiology0.88965548
90MP0004742_abnormal_vestibular_system0.88539063
91MP0000249_abnormal_blood_vessel0.88505839
92MP0004142_abnormal_muscle_tone0.87417105
93MP0008961_abnormal_basal_metabolism0.87150503
94MP0002925_abnormal_cardiovascular_devel0.86929511
95MP0003303_peritoneal_inflammation0.85603889
96MP0004484_altered_response_of0.84881379
97MP0003191_abnormal_cellular_cholesterol0.83640520
98MP0010352_gastrointestinal_tract_polyps0.83294037
99MP0005645_abnormal_hypothalamus_physiol0.83085491
100MP0001177_atelectasis0.82606450
101MP0005076_abnormal_cell_differentiation0.82564188
102MP0005171_absent_coat_pigmentation0.79857258
103MP0003690_abnormal_glial_cell0.77503710
104MP0003632_abnormal_nervous_system0.77268606
105MP0002069_abnormal_eating/drinking_beha0.76882275
106MP0004883_abnormal_blood_vessel0.76133600
107MP0005535_abnormal_body_temperature0.74800867
108MP0003448_altered_tumor_morphology0.74644024
109MP0004085_abnormal_heartbeat0.74576619
110MP0001784_abnormal_fluid_regulation0.72970152
111MP0005623_abnormal_meninges_morphology0.71861664
112MP0002128_abnormal_blood_circulation0.70981151
113MP0001191_abnormal_skin_condition0.70525082
114MP0001614_abnormal_blood_vessel0.69956576
115MP0002127_abnormal_cardiovascular_syste0.69754413
116MP0003950_abnormal_plasma_membrane0.69524083
117MP0003436_decreased_susceptibility_to0.67845458
118MP0003634_abnormal_glial_cell0.66707736
119MP0005166_decreased_susceptibility_to0.66573173
120MP0009764_decreased_sensitivity_to0.66018343
121MP0003385_abnormal_body_wall0.65014143
122MP0004134_abnormal_chest_morphology0.64992419
123MP0005000_abnormal_immune_tolerance0.64688611
124MP0002229_neurodegeneration0.63662122
125MP0005464_abnormal_platelet_physiology0.63440030
126MP0000733_abnormal_muscle_development0.61679213
127MP0001963_abnormal_hearing_physiology0.60420094
128MP0000015_abnormal_ear_pigmentation0.59982441
129MP0000013_abnormal_adipose_tissue0.58679844
130MP0006138_congestive_heart_failure0.58625283
131MP0004947_skin_inflammation0.58501563
132MP0005671_abnormal_response_to0.58453336
133MP0002405_respiratory_system_inflammati0.58449336
134MP0001485_abnormal_pinna_reflex0.56499146
135MP0005174_abnormal_tail_pigmentation0.53851436
136MP0000631_abnormal_neuroendocrine_gland0.53622310
137MP0001943_abnormal_respiration0.52203259
138MP0008877_abnormal_DNA_methylation0.51093302
139MP0010769_abnormal_survival0.50984925
140MP0001664_abnormal_digestion0.50539245
141MP0002082_postnatal_lethality0.48452809
142MP0010770_preweaning_lethality0.48452809
143MP0010768_mortality/aging0.47811760
144MP0003956_abnormal_body_size0.46954252
145MP0004215_abnormal_myocardial_fiber0.46542859
146MP0000751_myopathy0.46162751
147MP0003861_abnormal_nervous_system0.45152826
148MP0003300_gastrointestinal_ulcer0.44744713
149MP0003122_maternal_imprinting0.44638167
150MP0004145_abnormal_muscle_electrophysio0.43264986
151MP0003763_abnormal_thymus_physiology0.41016176
152MP0002752_abnormal_somatic_nervous0.40053323
153MP0002090_abnormal_vision0.40044491

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.09631976
2Myokymia (HP:0002411)6.33775109
3Focal seizures (HP:0007359)5.92526930
4Visual hallucinations (HP:0002367)4.99338065
5Epileptic encephalopathy (HP:0200134)4.84801671
6Atonic seizures (HP:0010819)4.59965798
7Febrile seizures (HP:0002373)4.20652811
8Papillary thyroid carcinoma (HP:0002895)4.18796590
9Broad-based gait (HP:0002136)4.02044759
10Absence seizures (HP:0002121)4.00997056
11Hyperventilation (HP:0002883)3.87393382
12Dialeptic seizures (HP:0011146)3.86749022
13Progressive cerebellar ataxia (HP:0002073)3.86397044
14Poor eye contact (HP:0000817)3.81866405
15Gaze-evoked nystagmus (HP:0000640)3.72343389
16Action tremor (HP:0002345)3.58772228
17Amblyopia (HP:0000646)3.37734691
18Generalized tonic-clonic seizures (HP:0002069)3.37694344
19Impaired vibration sensation in the lower limbs (HP:0002166)3.35758291
20Abnormality of binocular vision (HP:0011514)3.33502425
21Diplopia (HP:0000651)3.33502425
22Truncal ataxia (HP:0002078)3.33498670
23Abnormal social behavior (HP:0012433)3.29735172
24Impaired social interactions (HP:0000735)3.29735172
25Scanning speech (HP:0002168)3.24673460
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.23757752
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.23757752
28Dysmetria (HP:0001310)3.22443670
29Impaired smooth pursuit (HP:0007772)3.16126876
30Papilledema (HP:0001085)3.12623668
31Supranuclear gaze palsy (HP:0000605)3.09101228
32Drooling (HP:0002307)3.00768668
33Excessive salivation (HP:0003781)3.00768668
34Stereotypic behavior (HP:0000733)3.00540633
35Spontaneous hematomas (HP:0007420)3.00132628
36Anxiety (HP:0000739)2.99543511
37Urinary bladder sphincter dysfunction (HP:0002839)2.98702902
38Urinary urgency (HP:0000012)2.95151300
39Depression (HP:0000716)2.94381969
40Dysdiadochokinesis (HP:0002075)2.93505418
41Progressive inability to walk (HP:0002505)2.88563458
42Cerebral inclusion bodies (HP:0100314)2.86637738
43Genetic anticipation (HP:0003743)2.78069399
44Ankle clonus (HP:0011448)2.70568988
45Annular pancreas (HP:0001734)2.69897573
46Postural instability (HP:0002172)2.68963897
47Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.67371876
48Thyroid carcinoma (HP:0002890)2.66422364
49Abnormality of ocular smooth pursuit (HP:0000617)2.63427549
50Dysmetric saccades (HP:0000641)2.60636582
51Neurofibrillary tangles (HP:0002185)2.53385848
52Arterial tortuosity (HP:0005116)2.52190100
53Hemiparesis (HP:0001269)2.44576381
54Absent speech (HP:0001344)2.43339068
55Bradykinesia (HP:0002067)2.42834791
56Mutism (HP:0002300)2.42381414
57Amyotrophic lateral sclerosis (HP:0007354)2.41971190
58Protruding tongue (HP:0010808)2.39777800
59Inability to walk (HP:0002540)2.38140213
60Subacute progressive viral hepatitis (HP:0006572)2.37795971
61Hemiplegia (HP:0002301)2.37537388
62Spastic gait (HP:0002064)2.35637627
63T lymphocytopenia (HP:0005403)2.34113530
64Intention tremor (HP:0002080)2.32075760
65Insidious onset (HP:0003587)2.32054274
66Termporal pattern (HP:0011008)2.32054274
67Inappropriate behavior (HP:0000719)2.31891478
68Blue irides (HP:0000635)2.31840008
69Abnormality of the musculature of the pelvis (HP:0001469)2.27484071
70Abnormality of the hip-girdle musculature (HP:0001445)2.27484071
71Torticollis (HP:0000473)2.26623143
72Vascular tortuosity (HP:0004948)2.25381657
73Abnormal eating behavior (HP:0100738)2.22663553
74Megalencephaly (HP:0001355)2.21296116
75Absent hand (HP:0004050)2.20989956
76Impaired vibratory sensation (HP:0002495)2.18128885
77Focal dystonia (HP:0004373)2.16967574
78Overgrowth (HP:0001548)2.16883359
79Pointed chin (HP:0000307)2.16852776
80Pelvic girdle muscle weakness (HP:0003749)2.15465076
81Lower limb amyotrophy (HP:0007210)2.14746808
82Abnormality of the lower motor neuron (HP:0002366)2.14527005
83Thickened helices (HP:0000391)2.13736974
84Lower limb asymmetry (HP:0100559)2.13569253
85Epileptiform EEG discharges (HP:0011182)2.12302914
86Aortic aneurysm (HP:0004942)2.10440412
87Abnormality of T cell number (HP:0011839)2.10347364
88Resting tremor (HP:0002322)2.08327581
89Dyskinesia (HP:0100660)2.07746918
90Autoamputation (HP:0001218)2.07444109
91Ankyloglossia (HP:0010296)2.06749369
92Hematochezia (HP:0002573)2.04121457
93Abnormality of the periventricular white matter (HP:0002518)2.02775663
94Cortical dysplasia (HP:0002539)2.00894634
95Lower limb muscle weakness (HP:0007340)2.00428483
96Abnormality of salivation (HP:0100755)1.99983628
97Abnormality of oral frenula (HP:0000190)1.99103833
98Deeply set eye (HP:0000490)1.97831166
99Abnormality of the corticospinal tract (HP:0002492)1.97633495
100Large earlobe (HP:0009748)1.96858231
101Shoulder girdle muscle weakness (HP:0003547)1.92103015
102Incomplete penetrance (HP:0003829)1.92069799
103Heterochromia iridis (HP:0001100)1.91469719
104Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91415955
105Adactyly (HP:0009776)1.91046514
106Craniofacial dystonia (HP:0012179)1.91003835
107Portal hypertension (HP:0001409)1.90982898
108Widely spaced teeth (HP:0000687)1.90514809
109Generalized hypopigmentation of hair (HP:0011358)1.90097202
110EEG with generalized epileptiform discharges (HP:0011198)1.89371938
111Vertebral arch anomaly (HP:0008438)1.89167494
112Type II lissencephaly (HP:0007260)1.88270082
113Apathy (HP:0000741)1.87952573
114Tetraparesis (HP:0002273)1.87698928
115Status epilepticus (HP:0002133)1.86507303
116Wrist flexion contracture (HP:0001239)1.86297798
117Gait ataxia (HP:0002066)1.84745327
118Peripheral hypomyelination (HP:0007182)1.84149518
119Deep palmar crease (HP:0006191)1.83509090
120Slow saccadic eye movements (HP:0000514)1.83467769
121Obstructive sleep apnea (HP:0002870)1.82838937
122Skull defect (HP:0001362)1.82353101
123Fetal akinesia sequence (HP:0001989)1.81951307
124Generalized myoclonic seizures (HP:0002123)1.81526935
125Psychosis (HP:0000709)1.81396706
126Bladder carcinoma (HP:0002862)1.81328738
127Bladder neoplasm (HP:0009725)1.81328738
128Difficulty running (HP:0009046)1.80797126
129Heterotopia (HP:0002282)1.80567697
130Disinhibition (HP:0000734)1.80148221
131Fair hair (HP:0002286)1.80024642
132Split foot (HP:0001839)1.79352662
133Abnormality of saccadic eye movements (HP:0000570)1.78033162
134Spastic paraplegia (HP:0001258)1.77750516
135Hypoplasia of the iris (HP:0007676)1.76894887
136Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76449254
137Absent frontal sinuses (HP:0002688)1.75959042
138Clumsiness (HP:0002312)1.75773616
139Transitional cell carcinoma of the bladder (HP:0006740)1.75745554
140Hypsarrhythmia (HP:0002521)1.75631311
141Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.75039940
142Conjunctival telangiectasia (HP:0000524)1.74762014
143Neuronal loss in central nervous system (HP:0002529)1.73927727
144Curly hair (HP:0002212)1.72633089
145Paraplegia (HP:0010550)1.72469937
146Medulloblastoma (HP:0002885)1.71937892
147Clonus (HP:0002169)1.71663806
148Esophageal varix (HP:0002040)1.70711837
149Diminished motivation (HP:0000745)1.67733612
150Hammertoe (HP:0001765)1.66795966
151Decreased motor nerve conduction velocity (HP:0003431)1.64910610
152Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.63578528
153Abnormality of the hepatic vasculature (HP:0006707)1.63288898
154Exotropia (HP:0000577)1.62838710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.14918841
2TIE15.83044275
3NTRK34.46645419
4RIPK43.50688282
5MAP3K93.35404582
6MAP3K42.73543524
7MAP3K132.68387057
8BCR2.57783131
9DAPK22.45827315
10KSR22.37976845
11MAP2K72.35952965
12MINK12.20195482
13MAP3K122.09704593
14MARK12.03935804
15KSR11.99267198
16FES1.94977071
17TNIK1.93541065
18NTRK21.90504445
19DAPK11.84247715
20SIK21.83309174
21PAK61.78120290
22CAMKK11.75458536
23EPHA31.70364798
24RAF11.60294931
25NEK91.59084834
26MAP2K41.55592960
27CDK191.54711043
28CDK51.49405594
29PNCK1.48498310
30PLK21.43698084
31PRKD31.42647489
32BMPR21.41814293
33CAMKK21.39643942
34BRD41.39373978
35NTRK11.39121884
36ERBB31.35873178
37TGFBR21.33783281
38TYRO31.31844021
39TEC1.29928011
40JAK11.22449454
41ARAF1.20052010
42CASK1.15595507
43PTK2B1.14873934
44CSK1.14013927
45PRPF4B1.11990044
46FER1.10994935
47PDGFRA1.09409284
48MAP3K51.07796330
49MAP3K141.05605847
50PINK11.05098537
51CDK61.03552710
52MAPK130.98002005
53IKBKE0.96460921
54STK110.93949452
55PRKCH0.93671392
56MAP3K20.93384949
57KDR0.93148035
58YES10.90771821
59PIK3CG0.89411740
60PDK10.88770869
61CAMK2B0.88716562
62CAMK2A0.87891172
63TXK0.87885735
64FGR0.87272232
65PRKCG0.85337424
66TAOK10.84985296
67GRK60.84645508
68GRK50.82731779
69RET0.81815226
70SGK10.81279545
71DMPK0.80829185
72SGK20.77807795
73MARK20.76751639
74CAMK10.76575482
75TNK20.76330542
76EPHB10.72895379
77SGK4940.72714766
78SGK2230.72714766
79CSNK1A1L0.70048682
80MAP3K70.69558867
81PDPK10.68340607
82ZAP700.67249357
83PRKCQ0.66611796
84LATS10.66074447
85AKT30.65820616
86CDK180.65786397
87LATS20.65066335
88UHMK10.64898762
89STK380.64553947
90CDK150.63778715
91SGK30.63667941
92SYK0.63494557
93MAP3K10.63293091
94FGFR30.62353421
95CSNK1G20.62257424
96EGFR0.61370173
97CLK10.61218623
98DYRK1B0.60630689
99CDK140.60571102
100JAK20.57096450
101DYRK1A0.56950240
102BTK0.56890162
103TGFBR10.56814786
104ALK0.56771613
105CDK11A0.55249318
106MAP3K60.54913818
107LCK0.54865822
108FYN0.51708967
109RIPK10.50818481
110INSRR0.48776182
111FGFR20.48667767
112CDK120.48665502
113OXSR10.45312939
114RPS6KB10.44996641
115HCK0.44736532
116TRIM280.43510180
117SIK30.43163535
118MAPK100.41597245
119PAK30.41547978
120MAPK120.40879831
121RPS6KA30.39560554
122ROCK20.37155697
123MOS0.36286113
124SCYL20.34916499
125CCNB10.31784012
126CAMK40.31422749
127DAPK30.30177740
128NEK60.29623104
129PRKCE0.29369278
130MAP2K10.28390182
131PRKCZ0.27673040
132PRKCB0.27589444
133PDGFRB0.27397393
134CAMK1G0.26924967
135PRKD20.26320871
136CAMK2D0.25657009
137MAP4K10.25129108
138MAPK70.25019260
139JAK30.22900670

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35773398
2Long-term potentiation_Homo sapiens_hsa047203.00947620
3Olfactory transduction_Homo sapiens_hsa047402.62059510
4Circadian entrainment_Homo sapiens_hsa047132.57349344
5Amphetamine addiction_Homo sapiens_hsa050312.54197601
6Glutamatergic synapse_Homo sapiens_hsa047242.52150889
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48199254
8Morphine addiction_Homo sapiens_hsa050322.44630653
9GABAergic synapse_Homo sapiens_hsa047272.31481354
10Synaptic vesicle cycle_Homo sapiens_hsa047212.23783169
11Dopaminergic synapse_Homo sapiens_hsa047282.11618899
12Salivary secretion_Homo sapiens_hsa049702.07399800
13Renin secretion_Homo sapiens_hsa049241.87379538
14Long-term depression_Homo sapiens_hsa047301.85583901
15Cholinergic synapse_Homo sapiens_hsa047251.79889360
16Gastric acid secretion_Homo sapiens_hsa049711.75987708
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75897179
18Oxytocin signaling pathway_Homo sapiens_hsa049211.75203413
19Cocaine addiction_Homo sapiens_hsa050301.69439644
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66838707
21Calcium signaling pathway_Homo sapiens_hsa040201.59054392
22Serotonergic synapse_Homo sapiens_hsa047261.53526199
23Taste transduction_Homo sapiens_hsa047421.49730488
24Insulin secretion_Homo sapiens_hsa049111.49086559
25GnRH signaling pathway_Homo sapiens_hsa049121.44544318
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44043717
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42349126
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33437849
29cAMP signaling pathway_Homo sapiens_hsa040241.31673269
30Gap junction_Homo sapiens_hsa045401.31393275
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30760255
32Pancreatic cancer_Homo sapiens_hsa052121.30202585
33Glioma_Homo sapiens_hsa052141.30040027
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22476873
35Chronic myeloid leukemia_Homo sapiens_hsa052201.20683096
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17268178
37Estrogen signaling pathway_Homo sapiens_hsa049151.16970787
38Shigellosis_Homo sapiens_hsa051311.15834422
39Adherens junction_Homo sapiens_hsa045201.13188714
40ErbB signaling pathway_Homo sapiens_hsa040121.12155399
41TNF signaling pathway_Homo sapiens_hsa046681.10587406
42T cell receptor signaling pathway_Homo sapiens_hsa046601.10497126
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09807739
44Hepatitis B_Homo sapiens_hsa051611.08517446
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07979548
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04524550
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.03166722
48Axon guidance_Homo sapiens_hsa043601.02885630
49VEGF signaling pathway_Homo sapiens_hsa043701.02287488
50Melanogenesis_Homo sapiens_hsa049161.01434072
51Focal adhesion_Homo sapiens_hsa045101.00907016
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99744059
53Measles_Homo sapiens_hsa051620.99065598
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98806906
55Dorso-ventral axis formation_Homo sapiens_hsa043200.98550342
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.95535689
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95255427
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.93386271
59Malaria_Homo sapiens_hsa051440.93276446
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92205373
61MAPK signaling pathway_Homo sapiens_hsa040100.91983953
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91462930
63Choline metabolism in cancer_Homo sapiens_hsa052310.89460279
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89266461
65Type II diabetes mellitus_Homo sapiens_hsa049300.87638884
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.87353221
67Non-small cell lung cancer_Homo sapiens_hsa052230.86618279
68B cell receptor signaling pathway_Homo sapiens_hsa046620.86078371
69Viral carcinogenesis_Homo sapiens_hsa052030.85873129
70Acute myeloid leukemia_Homo sapiens_hsa052210.85092657
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84498982
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83949243
73Small cell lung cancer_Homo sapiens_hsa052220.83835506
74FoxO signaling pathway_Homo sapiens_hsa040680.83707142
75Oocyte meiosis_Homo sapiens_hsa041140.83293698
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.83114459
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80799493
78Proteoglycans in cancer_Homo sapiens_hsa052050.80388338
79Chemokine signaling pathway_Homo sapiens_hsa040620.80265023
80African trypanosomiasis_Homo sapiens_hsa051430.80123991
81Amoebiasis_Homo sapiens_hsa051460.79463433
82Collecting duct acid secretion_Homo sapiens_hsa049660.78608703
83Toxoplasmosis_Homo sapiens_hsa051450.77216884
84MicroRNAs in cancer_Homo sapiens_hsa052060.77046311
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.76403630
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75572309
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75464472
88Rap1 signaling pathway_Homo sapiens_hsa040150.75343841
89HIF-1 signaling pathway_Homo sapiens_hsa040660.75230274
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73268976
91Type I diabetes mellitus_Homo sapiens_hsa049400.73168293
92ECM-receptor interaction_Homo sapiens_hsa045120.73054323
93Pancreatic secretion_Homo sapiens_hsa049720.72544346
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.72066973
95Ras signaling pathway_Homo sapiens_hsa040140.71246295
96Hepatitis C_Homo sapiens_hsa051600.67456412
97Platelet activation_Homo sapiens_hsa046110.66427106
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65929462
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65348701
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65265862
101Renal cell carcinoma_Homo sapiens_hsa052110.65053551
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64431902
103Pathways in cancer_Homo sapiens_hsa052000.64014671
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63306414
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62190561
106Inositol phosphate metabolism_Homo sapiens_hsa005620.61102565
107Alcoholism_Homo sapiens_hsa050340.60824872
108Thyroid hormone synthesis_Homo sapiens_hsa049180.60352039
109mTOR signaling pathway_Homo sapiens_hsa041500.59493970
110Osteoclast differentiation_Homo sapiens_hsa043800.53918293
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53689563
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53518240
113Dilated cardiomyopathy_Homo sapiens_hsa054140.53143220
114Colorectal cancer_Homo sapiens_hsa052100.52781368
115Endocytosis_Homo sapiens_hsa041440.50841668
116Endometrial cancer_Homo sapiens_hsa052130.49808352
117Vibrio cholerae infection_Homo sapiens_hsa051100.48309585
118Nitrogen metabolism_Homo sapiens_hsa009100.48159853
119Wnt signaling pathway_Homo sapiens_hsa043100.47838048
120Glucagon signaling pathway_Homo sapiens_hsa049220.46880060
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45071292
122Primary immunodeficiency_Homo sapiens_hsa053400.44142009
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42746052
124Phototransduction_Homo sapiens_hsa047440.42033617
125Prolactin signaling pathway_Homo sapiens_hsa049170.41593597
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40328172
127Salmonella infection_Homo sapiens_hsa051320.40281143
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39743384
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39600855
130Circadian rhythm_Homo sapiens_hsa047100.39502536
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36897811
132Cardiac muscle contraction_Homo sapiens_hsa042600.36106935

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