CDK16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.50774040
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91050010
3locomotory exploration behavior (GO:0035641)4.88888259
4Golgi transport vesicle coating (GO:0048200)4.82814780
5COPI coating of Golgi vesicle (GO:0048205)4.82814780
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.72152165
7sodium ion export (GO:0071436)4.69877130
8layer formation in cerebral cortex (GO:0021819)4.55287608
9cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.45992880
10protein retention in ER lumen (GO:0006621)4.30217427
11cell communication by electrical coupling (GO:0010644)4.27223722
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.26188819
13glutamate secretion (GO:0014047)4.10068383
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.07426369
15synaptic vesicle exocytosis (GO:0016079)4.04726474
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.02070330
17regulation of synapse structural plasticity (GO:0051823)3.86489207
18positive regulation of synapse maturation (GO:0090129)3.85914633
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.85357578
20regulation of synaptic vesicle exocytosis (GO:2000300)3.84883450
21cellular potassium ion homeostasis (GO:0030007)3.81229395
22regulation of mammary gland epithelial cell proliferation (GO:0033599)3.80599259
23vocalization behavior (GO:0071625)3.76824141
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67590441
25establishment of nucleus localization (GO:0040023)3.67532608
26activation of protein kinase A activity (GO:0034199)3.63936991
27adherens junction assembly (GO:0034333)3.58170905
28plasma membrane repair (GO:0001778)3.57100917
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.56672874
30cytoskeletal anchoring at plasma membrane (GO:0007016)3.53056059
31dendritic spine morphogenesis (GO:0060997)3.51219472
32proline transport (GO:0015824)3.48950416
33proline biosynthetic process (GO:0006561)3.45329771
34peptidyl-arginine omega-N-methylation (GO:0035247)3.41501723
35neurotransmitter secretion (GO:0007269)3.39917515
36negative regulation of potassium ion transmembrane transport (GO:1901380)3.39065389
37cell communication involved in cardiac conduction (GO:0086065)3.38659132
38exploration behavior (GO:0035640)3.36989367
39regulation of synaptic vesicle transport (GO:1902803)3.36291090
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.34765387
41cerebellar Purkinje cell layer development (GO:0021680)3.33722317
42regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.24987659
43cell migration in hindbrain (GO:0021535)3.22827859
44neuromuscular process controlling balance (GO:0050885)3.22340897
45cell-substrate adherens junction assembly (GO:0007045)3.19395670
46focal adhesion assembly (GO:0048041)3.19395670
47neuronal action potential propagation (GO:0019227)3.14768201
48response to pheromone (GO:0019236)3.13280679
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12442527
50negative regulation of cell size (GO:0045792)3.12360243
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10446077
52regulation of translational fidelity (GO:0006450)3.10276149
53negative regulation of microtubule polymerization (GO:0031115)3.08280055
54regulation of neuronal synaptic plasticity (GO:0048168)3.05498625
55regulation of glutamate receptor signaling pathway (GO:1900449)3.05349238
56membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.03868870
57regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03837476
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.03214556
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03182557
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98840644
61membrane repolarization (GO:0086009)2.98522746
62dendrite morphogenesis (GO:0048813)2.98129343
63potassium ion import (GO:0010107)2.96192861
64glycine transport (GO:0015816)2.95992418
65regulation of ARF protein signal transduction (GO:0032012)2.94884617
66negative regulation of catenin import into nucleus (GO:0035414)2.92758469
67positive regulation of potassium ion transmembrane transport (GO:1901381)2.92707884
68nuclear envelope reassembly (GO:0031468)2.91511816
69mitotic nuclear envelope reassembly (GO:0007084)2.91511816
70cellular sodium ion homeostasis (GO:0006883)2.88959376
71peptidyl-arginine methylation (GO:0018216)2.88455096
72peptidyl-arginine N-methylation (GO:0035246)2.88455096
73cerebellar granule cell differentiation (GO:0021707)2.87666502
74mitotic chromosome condensation (GO:0007076)2.87022582
75protein localization to endosome (GO:0036010)2.86893284
76potassium ion homeostasis (GO:0055075)2.85304932
77positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.83330875
78cerebellar Purkinje cell differentiation (GO:0021702)2.82486965
79regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.82482159
80regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82247982
81regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.80988738
82regulation of membrane repolarization (GO:0060306)2.80612225
83DNA unwinding involved in DNA replication (GO:0006268)2.80448531
84regulation of clathrin-mediated endocytosis (GO:2000369)2.80145347
85protein complex localization (GO:0031503)2.78107131
86protein localization to synapse (GO:0035418)2.76249112
87regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74554618
88apoptotic process involved in morphogenesis (GO:0060561)2.73757581
89glycolytic process (GO:0006096)2.73149363
90spliceosomal tri-snRNP complex assembly (GO:0000244)2.72237680
91cell-cell junction maintenance (GO:0045217)2.71972555
92gamma-aminobutyric acid transport (GO:0015812)2.71811080
93histone arginine methylation (GO:0034969)2.71407603
94membrane depolarization during action potential (GO:0086010)2.70340972
95cellular protein complex localization (GO:0034629)2.70058836
96positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.70041199
97regulation of cardioblast differentiation (GO:0051890)2.69151722
98basement membrane organization (GO:0071711)2.68953887
99gluconeogenesis (GO:0006094)2.68893578
100maternal placenta development (GO:0001893)2.68735236
101membrane repolarization during action potential (GO:0086011)2.68410165
102innervation (GO:0060384)2.67176452
103convergent extension (GO:0060026)2.66784217
104cochlea morphogenesis (GO:0090103)2.66396874
105neuromuscular process controlling posture (GO:0050884)2.66392862
106protein targeting to plasma membrane (GO:0072661)2.62544255
107dendritic spine organization (GO:0097061)2.61812407
108regulation of early endosome to late endosome transport (GO:2000641)2.61482278
109synaptic vesicle endocytosis (GO:0048488)2.60371900
110semaphorin-plexin signaling pathway (GO:0071526)2.60326441
111epithelial cell-cell adhesion (GO:0090136)2.59731307
112paraxial mesoderm development (GO:0048339)2.59095818
113positive regulation of sodium ion transport (GO:0010765)2.57888552
114establishment of mitochondrion localization (GO:0051654)2.56336672
115mitochondrion transport along microtubule (GO:0047497)2.56252604
116establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.56252604
117protein maturation by protein folding (GO:0022417)2.55915222
118synaptic transmission, glutamatergic (GO:0035249)2.55504220
119cell-substrate junction assembly (GO:0007044)2.54979875
120nucleosome disassembly (GO:0006337)2.54750955
121protein-DNA complex disassembly (GO:0032986)2.54750955
122heterochromatin organization (GO:0070828)2.54433128
123vesicle transport along microtubule (GO:0047496)2.54309637
124activation of Rac GTPase activity (GO:0032863)2.53686692
125long-term memory (GO:0007616)2.53266627
126peptidyl-lysine dimethylation (GO:0018027)2.52972112
127negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.52922439
128regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.51413646
129auditory behavior (GO:0031223)2.50772211
130regulation of NFAT protein import into nucleus (GO:0051532)2.50544224
131organelle transport along microtubule (GO:0072384)2.50416685
132Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.49321930
133glucose 6-phosphate metabolic process (GO:0051156)2.49318362
134respiratory system process (GO:0003016)2.49178811
135negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48578945
136neurotransmitter transport (GO:0006836)2.48519972
137intracellular estrogen receptor signaling pathway (GO:0030520)2.47746076
138positive regulation of potassium ion transport (GO:0043268)2.47641098
139hexose biosynthetic process (GO:0019319)2.46903061
140protein insertion into membrane (GO:0051205)2.46692585
141ionotropic glutamate receptor signaling pathway (GO:0035235)2.46161303
142protein localization to microtubule (GO:0035372)2.46019366
143stress fiber assembly (GO:0043149)2.45198221
144axon cargo transport (GO:0008088)2.44742560
145cardiac myofibril assembly (GO:0055003)2.44666432
146peptidyl-proline hydroxylation (GO:0019511)2.43522756
147negative regulation of organelle assembly (GO:1902116)2.43015118
148regulation of synapse maturation (GO:0090128)2.42792217
149regulation of calcium ion transmembrane transport (GO:1903169)2.42725753
150regulation of calcium ion transmembrane transporter activity (GO:1901019)2.42725753
151activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42679143
152cardiac muscle contraction (GO:0060048)2.42257781
153neuromuscular process (GO:0050905)2.41801752
154regulation of potassium ion transmembrane transport (GO:1901379)2.41473133
155alanine transport (GO:0032328)2.41254782
1564-hydroxyproline metabolic process (GO:0019471)2.40541996
157positive regulation of axon extension (GO:0045773)2.40270805
158regulation of dendritic spine morphogenesis (GO:0061001)2.39251271
159regulation of potassium ion transmembrane transporter activity (GO:1901016)2.38571691
160mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.37981379
161regulation of establishment of planar polarity (GO:0090175)2.37776269
162monosaccharide biosynthetic process (GO:0046364)2.35707736
163positive regulation of nuclease activity (GO:0032075)2.34516700
164vesicle coating (GO:0006901)2.32751860
165mitochondrial fusion (GO:0008053)2.31590715
166outflow tract septum morphogenesis (GO:0003148)2.30134837
167proline metabolic process (GO:0006560)2.28472911
168amyloid precursor protein catabolic process (GO:0042987)2.25867425
169protein hydroxylation (GO:0018126)2.25013859
170regulation of glucose import in response to insulin stimulus (GO:2001273)2.24755185
171axon extension (GO:0048675)2.24422057
172regulation of mitotic spindle organization (GO:0060236)2.24129977
173creatine metabolic process (GO:0006600)2.20088575
174regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.20026934
175positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.20026934
176RNA stabilization (GO:0043489)2.19939613
177mRNA stabilization (GO:0048255)2.19939613
1783-UTR-mediated mRNA stabilization (GO:0070935)2.19627195
179RNA localization (GO:0006403)2.18427010
180NADH metabolic process (GO:0006734)2.17744701
181embryonic skeletal joint morphogenesis (GO:0060272)2.17652077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.93213403
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.17669509
3ZFP281_18757296_ChIP-ChIP_E14_Mouse2.64702484
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.50960283
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.42506044
6DROSHA_22980978_ChIP-Seq_HELA_Human2.38868540
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36382823
8KDM2B_26808549_Chip-Seq_K562_Human2.29434612
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23874587
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22669611
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22669611
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18864979
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16873794
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.12541903
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10982569
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.07065453
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.01492632
18CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.00779595
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99349615
20ZNF263_19887448_ChIP-Seq_K562_Human1.97970968
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95578656
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94810001
23ZFP281_27345836_Chip-Seq_ESCs_Mouse1.93550529
24EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.93529753
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93436806
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92772188
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91539049
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91029952
29REST_21632747_ChIP-Seq_MESCs_Mouse1.90344904
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89337994
31E2F7_22180533_ChIP-Seq_HELA_Human1.88449560
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.86916275
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.86838465
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85959977
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82937862
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81495590
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80531746
38KDM2B_26808549_Chip-Seq_DND41_Human1.80444903
39LXR_22292898_ChIP-Seq_THP-1_Human1.78016446
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77699748
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77289388
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.76310157
43CLOCK_20551151_ChIP-Seq_293T_Human1.76308537
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.75517940
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.73019201
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72262861
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68120089
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67330341
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65822180
50* XRN2_22483619_ChIP-Seq_HELA_Human1.63193808
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.63144110
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.63030061
53VDR_21846776_ChIP-Seq_THP-1_Human1.62961683
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.61650969
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61046228
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58937697
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55943109
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53349865
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52957594
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52884319
61CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.51790332
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51770017
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50373457
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49798672
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49655764
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48379866
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45767110
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43858278
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41481934
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41423131
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39928121
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.39780467
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37451287
74SMC4_20622854_ChIP-Seq_HELA_Human1.37325171
75TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.36945815
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.36721736
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36454786
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35089512
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34842434
80* CREB1_26743006_Chip-Seq_LNCaP_Human1.34624390
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31505185
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.31121372
83TET1_21490601_ChIP-Seq_MESCs_Mouse1.31008539
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30767929
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30650555
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30316181
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.29857097
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29493173
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27651151
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.27293098
91CTCF_27219007_Chip-Seq_Bcells_Human1.27013274
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27002990
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26591201
94ZNF274_21170338_ChIP-Seq_K562_Hela1.26417492
95RACK7_27058665_Chip-Seq_MCF-7_Human1.25343254
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23702483
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21923616
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21000534
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20660228
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20434436
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20306057
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19955538
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19518863
104TRIM28_21343339_ChIP-Seq_HEK293_Human1.18558092
105P68_20966046_ChIP-Seq_HELA_Human1.17078390
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16319281
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.15937271
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15382619
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13080022
110TP53_22127205_ChIP-Seq_IMR90_Human1.12510967
111AR_19668381_ChIP-Seq_PC3_Human1.11101476
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10789574
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10742094
114NANOG_21062744_ChIP-ChIP_HESCs_Human1.09914015
115OCT4_19829295_ChIP-Seq_ESCs_Human1.08940002
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08897638
117NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08128921
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07680193
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06501321
120MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05752108
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05222337
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04906277
123ELK3_25401928_ChIP-Seq_HUVEC_Human1.04693342
124OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04142275
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04138847
126RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04061016
127TP53_20018659_ChIP-ChIP_R1E_Mouse1.03967055
128KLF4_19829295_ChIP-Seq_ESCs_Human1.03916926
129EGR1_19374776_ChIP-ChIP_THP-1_Human1.03060003
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02710312
131TP53_23651856_ChIP-Seq_MEFs_Mouse1.01739900
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00809917
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.99643356
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99234622
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98714411
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96377186
137TP63_22573176_ChIP-Seq_HFKS_Human0.96215542
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.96034746
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.96034746
140TCF7_22412390_ChIP-Seq_EML_Mouse0.96033984
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.94625288
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.93089839
143ATF3_27146783_Chip-Seq_COLON_Human0.93050905
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92067493
145ISL1_27105846_Chip-Seq_CPCs_Mouse0.91125403
146NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90096047
147MYC_22102868_ChIP-Seq_BL_Human0.89848832
148MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89254136
149SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86807032
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86186435
151SOX2_21211035_ChIP-Seq_LN229_Gbm0.85879529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.20356964
2MP0004270_analgesia3.00987708
3MP0003635_abnormal_synaptic_transmissio2.87730772
4MP0004858_abnormal_nervous_system2.66132697
5MP0010030_abnormal_orbit_morphology2.64090749
6MP0000751_myopathy2.55697840
7MP0003283_abnormal_digestive_organ2.34669556
8MP0005451_abnormal_body_composition2.29921257
9MP0002837_dystrophic_cardiac_calcinosis2.27314557
10MP0004145_abnormal_muscle_electrophysio2.25413358
11MP0002909_abnormal_adrenal_gland2.21712761
12MP0009780_abnormal_chondrocyte_physiolo2.14483877
13MP0003705_abnormal_hypodermis_morpholog2.14427415
14MP0002249_abnormal_larynx_morphology2.11674114
15MP0002063_abnormal_learning/memory/cond2.10394777
16MP0004084_abnormal_cardiac_muscle2.03066197
17MP0009046_muscle_twitch2.01540101
18MP0004233_abnormal_muscle_weight1.99809132
19MP0002734_abnormal_mechanical_nocicepti1.94228923
20MP0008438_abnormal_cutaneous_collagen1.89312899
21MP0001346_abnormal_lacrimal_gland1.84209423
22MP0002064_seizures1.78429942
23MP0000678_abnormal_parathyroid_gland1.78176394
24MP0003566_abnormal_cell_adhesion1.76702304
25MP0008569_lethality_at_weaning1.75829634
26MP0004215_abnormal_myocardial_fiber1.74832598
27MP0003329_amyloid_beta_deposits1.73401277
28MP0008961_abnormal_basal_metabolism1.72462617
29MP0004272_abnormal_basement_membrane1.72181715
30MP0009745_abnormal_behavioral_response1.70497108
31MP0005257_abnormal_intraocular_pressure1.67632244
32MP0005623_abnormal_meninges_morphology1.67457183
33MP0003646_muscle_fatigue1.66403462
34MP0000566_synostosis1.60707853
35MP0002733_abnormal_thermal_nociception1.55836220
36MP0004811_abnormal_neuron_physiology1.53474206
37MP0000013_abnormal_adipose_tissue1.53137741
38MP0001968_abnormal_touch/_nociception1.52629391
39MP0002184_abnormal_innervation1.52198752
40MP0002572_abnormal_emotion/affect_behav1.48102824
41MP0004087_abnormal_muscle_fiber1.47619962
42MP0009672_abnormal_birth_weight1.47275062
43MP0002653_abnormal_ependyma_morphology1.44616360
44MP0004036_abnormal_muscle_relaxation1.44105066
45MP0000747_muscle_weakness1.44055620
46MP0000955_abnormal_spinal_cord1.43191809
47MP0002272_abnormal_nervous_system1.41711924
48MP0003137_abnormal_impulse_conducting1.41698598
49MP0003111_abnormal_nucleus_morphology1.41134765
50MP0003942_abnormal_urinary_system1.40678549
51MP0005409_darkened_coat_color1.38731590
52MP0004885_abnormal_endolymph1.36836112
53MP0003385_abnormal_body_wall1.35620278
54MP0002269_muscular_atrophy1.35194275
55MP0008932_abnormal_embryonic_tissue1.34549591
56MP0001970_abnormal_pain_threshold1.33210758
57MP0000778_abnormal_nervous_system1.31503928
58MP0005058_abnormal_lysosome_morphology1.30716746
59MP0003880_abnormal_central_pattern1.30429926
60MP0005423_abnormal_somatic_nervous1.29781240
61MP0004130_abnormal_muscle_cell1.28515367
62MP0001730_embryonic_growth_arrest1.28383776
63MP0001440_abnormal_grooming_behavior1.26461464
64MP0003879_abnormal_hair_cell1.26122761
65MP0003122_maternal_imprinting1.25721393
66MP0000762_abnormal_tongue_morphology1.25594850
67MP0008260_abnormal_autophagy1.25198095
68MP0000749_muscle_degeneration1.23054742
69MP0001486_abnormal_startle_reflex1.22484964
70MP0000759_abnormal_skeletal_muscle1.20689437
71MP0002735_abnormal_chemical_nociception1.18839938
72MP0000003_abnormal_adipose_tissue1.17794679
73MP0002067_abnormal_sensory_capabilities1.17437950
74MP0000579_abnormal_nail_morphology1.17067237
75MP0002234_abnormal_pharynx_morphology1.15316173
76MP0001299_abnormal_eye_distance/1.14142026
77MP0005187_abnormal_penis_morphology1.13990468
78MP0000537_abnormal_urethra_morphology1.12422525
79MP0002697_abnormal_eye_size1.12168011
80MP0004085_abnormal_heartbeat1.11955064
81MP0000750_abnormal_muscle_regeneration1.11360117
82MP0002106_abnormal_muscle_physiology1.11215300
83MP0000049_abnormal_middle_ear1.10799260
84MP0005620_abnormal_muscle_contractility1.10702098
85MP0004185_abnormal_adipocyte_glucose1.09381837
86MP0009053_abnormal_anal_canal1.07126714
87MP0002882_abnormal_neuron_morphology1.07103518
88MP0005330_cardiomyopathy1.07094259
89MP0005501_abnormal_skin_physiology1.05249461
90MP0003119_abnormal_digestive_system1.04986768
91MP0001849_ear_inflammation1.04840679
92MP0000534_abnormal_ureter_morphology1.04677748
93MP0002066_abnormal_motor_capabilities/c1.02881260
94MP0002089_abnormal_postnatal_growth/wei1.02647058
95MP0002152_abnormal_brain_morphology1.01143436
96MP0004043_abnormal_pH_regulation1.01019428
97MP0004924_abnormal_behavior1.00648361
98MP0005386_behavior/neurological_phenoty1.00648361
99MP0002972_abnormal_cardiac_muscle1.00603122
100MP0002557_abnormal_social/conspecific_i0.99462515
101MP0003453_abnormal_keratinocyte_physiol0.98225314
102MP0003115_abnormal_respiratory_system0.98099749
103MP0002085_abnormal_embryonic_tissue0.98045593
104MP0001672_abnormal_embryogenesis/_devel0.97640165
105MP0005380_embryogenesis_phenotype0.97640165
106MP0005369_muscle_phenotype0.97528822
107MP0002736_abnormal_nociception_after0.97047110
108MP0008775_abnormal_heart_ventricle0.96459211
109MP0002080_prenatal_lethality0.95597495
110MP0004484_altered_response_of0.93347455
111MP0003091_abnormal_cell_migration0.92876799
112MP0003984_embryonic_growth_retardation0.92609721
113MP0000462_abnormal_digestive_system0.91562678
114MP0002114_abnormal_axial_skeleton0.91158650
115MP0005375_adipose_tissue_phenotype0.90822452
116MP0003693_abnormal_embryo_hatching0.90610435
117MP0000350_abnormal_cell_proliferation0.90130221
118MP0010630_abnormal_cardiac_muscle0.89975088
119MP0002116_abnormal_craniofacial_bone0.89456065
120MP0003123_paternal_imprinting0.89096729
121MP0002084_abnormal_developmental_patter0.88958629
122MP0000467_abnormal_esophagus_morphology0.86960481
123MP0003077_abnormal_cell_cycle0.86608654
124MP0006138_congestive_heart_failure0.86116959
125MP0010234_abnormal_vibrissa_follicle0.85978139
126MP0002796_impaired_skin_barrier0.85252034
127MP0002088_abnormal_embryonic_growth/wei0.85242769
128MP0003861_abnormal_nervous_system0.84520093
129MP0004957_abnormal_blastocyst_morpholog0.84131166
130MP0003633_abnormal_nervous_system0.82869995
131MP0002896_abnormal_bone_mineralization0.82470087
132MP0003315_abnormal_perineum_morphology0.82151620
133MP0000733_abnormal_muscle_development0.81760987
134MP0005666_abnormal_adipose_tissue0.81508372
135MP0002092_abnormal_eye_morphology0.80182880
136MP0002877_abnormal_melanocyte_morpholog0.79630595
137MP0002081_perinatal_lethality0.79596121
138MP0004197_abnormal_fetal_growth/weight/0.78713593
139MP0005508_abnormal_skeleton_morphology0.78337856
140MP0001348_abnormal_lacrimal_gland0.78305888
141MP0000569_abnormal_digit_pigmentation0.77952620
142MP0002932_abnormal_joint_morphology0.77399306
143MP0000428_abnormal_craniofacial_morphol0.76787814
144MP0003935_abnormal_craniofacial_develop0.76416910
145MP0010352_gastrointestinal_tract_polyps0.76390318
146MP0005499_abnormal_olfactory_system0.76243407
147MP0005394_taste/olfaction_phenotype0.76243407
148MP0009250_abnormal_appendicular_skeleto0.76218242
149MP0001501_abnormal_sleep_pattern0.75637288
150MP0005076_abnormal_cell_differentiation0.74638641
151MP0003045_fibrosis0.74293020
152MP0002822_catalepsy0.73701402
153MP0001544_abnormal_cardiovascular_syste0.73670697
154MP0005385_cardiovascular_system_phenoty0.73670697
155MP0003634_abnormal_glial_cell0.73137552

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)4.22416457
2Myokymia (HP:0002411)3.96707494
3Abnormality of the lower motor neuron (HP:0002366)3.51698538
4Focal seizures (HP:0007359)3.34989628
5Action tremor (HP:0002345)3.22139206
6Ventricular fibrillation (HP:0001663)3.18595537
7Focal motor seizures (HP:0011153)3.08927548
8Bundle branch block (HP:0011710)3.07198657
9Distal lower limb amyotrophy (HP:0008944)3.00421047
10Premature rupture of membranes (HP:0001788)2.89978955
11Ulnar bowing (HP:0003031)2.88992651
12Sudden death (HP:0001699)2.79733920
13Ankle clonus (HP:0011448)2.71401925
14Difficulty running (HP:0009046)2.70141625
15Insomnia (HP:0100785)2.68488944
16Hyperacusis (HP:0010780)2.63173289
17Lower limb amyotrophy (HP:0007210)2.62462646
18Centrally nucleated skeletal muscle fibers (HP:0003687)2.61799352
19Distal upper limb amyotrophy (HP:0007149)2.55445406
20Upper limb amyotrophy (HP:0009129)2.55445406
21Shallow orbits (HP:0000586)2.55281820
22Dysmetric saccades (HP:0000641)2.54006359
23Hand muscle atrophy (HP:0009130)2.51331824
24Neoplasm of the heart (HP:0100544)2.48515673
25Pointed chin (HP:0000307)2.47368806
26Depression (HP:0000716)2.45637488
27Progressive cerebellar ataxia (HP:0002073)2.45223161
28Exercise-induced myalgia (HP:0003738)2.43467563
29Supranuclear gaze palsy (HP:0000605)2.42191837
30Spinal rigidity (HP:0003306)2.40303715
31Impaired social interactions (HP:0000735)2.31073480
32Abnormal social behavior (HP:0012433)2.31073480
33Absence seizures (HP:0002121)2.27538763
34Genetic anticipation (HP:0003743)2.27426595
35Abnormality of the calcaneus (HP:0008364)2.26170501
36Obstructive sleep apnea (HP:0002870)2.26154297
37Broad face (HP:0000283)2.26070448
38Poor eye contact (HP:0000817)2.25970456
39Myotonia (HP:0002486)2.23205824
40Long palpebral fissure (HP:0000637)2.22403272
41Cholecystitis (HP:0001082)2.20813724
42Abnormal gallbladder physiology (HP:0012438)2.20813724
43Annular pancreas (HP:0001734)2.19732436
44Achilles tendon contracture (HP:0001771)2.18530989
45Renal duplication (HP:0000075)2.17276224
46Hemiplegia (HP:0002301)2.15258194
47Vertebral compression fractures (HP:0002953)2.15223815
48Amyotrophic lateral sclerosis (HP:0007354)2.14166821
49Broad distal phalanx of finger (HP:0009836)2.13152474
50Difficulty climbing stairs (HP:0003551)2.10819861
51Broad metatarsal (HP:0001783)2.10543375
52Increased variability in muscle fiber diameter (HP:0003557)2.10024116
53Exercise-induced muscle cramps (HP:0003710)2.09413246
54Dysdiadochokinesis (HP:0002075)2.08802163
55Astrocytoma (HP:0009592)2.08699559
56Abnormality of the astrocytes (HP:0100707)2.08699559
57Megalencephaly (HP:0001355)2.07640974
58Hyporeflexia of lower limbs (HP:0002600)2.07577929
59Elfin facies (HP:0004428)2.06060129
60Macroorchidism (HP:0000053)2.05548703
61Disproportionate tall stature (HP:0001519)2.02575432
62Cerebral aneurysm (HP:0004944)2.02511862
63Hypercortisolism (HP:0001578)2.01056556
64Rapidly progressive (HP:0003678)1.99934325
65Distal lower limb muscle weakness (HP:0009053)1.99834865
66Epileptic encephalopathy (HP:0200134)1.99773478
67Generalized tonic-clonic seizures (HP:0002069)1.96980195
68Prolonged QT interval (HP:0001657)1.96867498
69Urinary urgency (HP:0000012)1.96648456
70Enlarged penis (HP:0000040)1.95765051
71Abnormality of the aortic arch (HP:0012303)1.95397934
72Ventricular arrhythmia (HP:0004308)1.93681902
73Calcaneovalgus deformity (HP:0001848)1.92476393
74Atonic seizures (HP:0010819)1.92236229
75Hammertoe (HP:0001765)1.91684521
76Dialeptic seizures (HP:0011146)1.91584907
77Protrusio acetabuli (HP:0003179)1.91541256
78Impaired smooth pursuit (HP:0007772)1.89973257
79Lymphangioma (HP:0100764)1.89259130
80Truncus arteriosus (HP:0001660)1.89164778
81Bowel diverticulosis (HP:0005222)1.88042499
82Papilledema (HP:0001085)1.87868264
83Transposition of the great arteries (HP:0001669)1.87729482
84Abnormal connection of the cardiac segments (HP:0011545)1.87729482
85Abnormal ventriculo-arterial connection (HP:0011563)1.87729482
86Short nail (HP:0001799)1.87606882
87Mitral regurgitation (HP:0001653)1.86589197
88Thin ribs (HP:0000883)1.86515617
89Cervical subluxation (HP:0003308)1.85719463
90Progressive muscle weakness (HP:0003323)1.85437087
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.85366438
92Abnormality of the Achilles tendon (HP:0005109)1.85288630
93EMG: neuropathic changes (HP:0003445)1.84382229
94Overriding aorta (HP:0002623)1.84355070
95Stridor (HP:0010307)1.84061401
96Resting tremor (HP:0002322)1.83959414
97Postural instability (HP:0002172)1.83455107
98Pheochromocytoma (HP:0002666)1.83100553
99Increased connective tissue (HP:0009025)1.82079813
100Urinary bladder sphincter dysfunction (HP:0002839)1.81657678
101Abnormal EKG (HP:0003115)1.81557584
102Mildly elevated creatine phosphokinase (HP:0008180)1.80258972
103Bladder diverticulum (HP:0000015)1.80146755
104Ragged-red muscle fibers (HP:0003200)1.80083218
105Heart block (HP:0012722)1.78532763
106Ependymoma (HP:0002888)1.78017234
107Cerebral inclusion bodies (HP:0100314)1.76995890
108Turricephaly (HP:0000262)1.76612108
109Abnormality of the phalanges of the hallux (HP:0010057)1.76587977
110Flat acetabular roof (HP:0003180)1.76578466
111Muscle fiber splitting (HP:0003555)1.76479055
112Precocious puberty (HP:0000826)1.76371579
113Arnold-Chiari malformation (HP:0002308)1.76277024
114Syncope (HP:0001279)1.76125785
115Type 1 muscle fiber predominance (HP:0003803)1.75774070
116Deviation of the thumb (HP:0009603)1.75706054
117Termporal pattern (HP:0011008)1.75427029
118Insidious onset (HP:0003587)1.75427029
119Trismus (HP:0000211)1.74899963
120Mutism (HP:0002300)1.74418107
121Impaired vibration sensation in the lower limbs (HP:0002166)1.73622048
122Abnormality of skeletal muscle fiber size (HP:0012084)1.73338011
123Intention tremor (HP:0002080)1.72585474
124Myoglobinuria (HP:0002913)1.72318797
125Genu recurvatum (HP:0002816)1.72175041
126Adducted thumb (HP:0001181)1.71949660
127Abnormality of ocular smooth pursuit (HP:0000617)1.71918525
128Back pain (HP:0003418)1.71878539
129Patellar dislocation (HP:0002999)1.71729907
130Abnormality of the distal phalanges of the toes (HP:0010182)1.71664917
131Primary atrial arrhythmia (HP:0001692)1.71386085
132Proximal placement of thumb (HP:0009623)1.71075727
133Abnormal atrioventricular conduction (HP:0005150)1.70867679
134Myopathic facies (HP:0002058)1.70606368
135Renovascular hypertension (HP:0100817)1.70446837
136Truncal ataxia (HP:0002078)1.70200690
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70010444
138Increased nuchal translucency (HP:0010880)1.69845443
139Long toe (HP:0010511)1.69170126
140Deformed tarsal bones (HP:0008119)1.68736244
141Congenital malformation of the right heart (HP:0011723)1.67620711
142Double outlet right ventricle (HP:0001719)1.67620711
143Neoplasm of the peripheral nervous system (HP:0100007)1.67390313
144Atrial fibrillation (HP:0005110)1.66575724
145Abnormality of the umbilical cord (HP:0010881)1.66510521
146Abnormality of dentin (HP:0010299)1.66372156
147Bronchomalacia (HP:0002780)1.66351372
148Tetraplegia (HP:0002445)1.65449167
149Hemiparesis (HP:0001269)1.65426425
150Foot dorsiflexor weakness (HP:0009027)1.63049642
151Fragile skin (HP:0001030)1.61787740
152Aplasia involving bones of the extremities (HP:0009825)1.61480312
153Aplasia involving bones of the upper limbs (HP:0009823)1.61480312
154Aplasia of the phalanges of the hand (HP:0009802)1.61480312
155Vertebral arch anomaly (HP:0008438)1.60996073
156Biconcave vertebral bodies (HP:0004586)1.58336275
157High anterior hairline (HP:0009890)1.54540647
158Hyperparathyroidism (HP:0000843)1.54200389
159Ankle contracture (HP:0006466)1.54074442
160Generalized amyotrophy (HP:0003700)1.52891909
161Advanced eruption of teeth (HP:0006288)1.52741277
162Pterygium (HP:0001059)1.52485942
163Wormian bones (HP:0002645)1.52236759
164Neurofibrillary tangles (HP:0002185)1.51836284
165Muscle fiber inclusion bodies (HP:0100299)1.51551993
166Rhizomelia (HP:0008905)1.51270545
167Asymmetry of the thorax (HP:0001555)1.51163636
168Premature skin wrinkling (HP:0100678)1.50868038
169Flattened epiphyses (HP:0003071)1.50346216
170Distal sensory impairment (HP:0002936)1.50029120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.33803064
2MAP3K93.25565046
3SMG12.90467016
4PRKD32.84980049
5MARK12.55482958
6RIPK12.54889125
7PAK62.52842367
8LATS22.32567735
9IRAK32.28842852
10NEK12.28600138
11NTRK32.28386207
12KSR22.26056235
13MINK12.12971510
14NTRK12.01530823
15MAP3K42.00676627
16CAMKK11.95143613
17TYRO31.93279098
18PHKG21.92108671
19PHKG11.92108671
20LMTK21.90322927
21PKN21.89442182
22TAOK11.81551503
23DAPK21.79875383
24STK381.74886692
25EPHA21.71471612
26KSR11.70172275
27PDGFRA1.64453977
28NME21.64119666
29ARAF1.58369634
30MAP2K41.47787581
31NTRK21.46646484
32TAOK21.45957895
33EPHA41.41126671
34TTN1.37954687
35SCYL21.37669462
36ICK1.31224290
37RET1.23940496
38ALK1.21333576
39PAK31.20192642
40BRAF1.15992637
41CAMKK21.14744451
42DMPK1.14658043
43DDR21.14036977
44UHMK11.09593875
45PDK31.03267118
46PDK41.03267118
47MAP3K21.02035089
48EEF2K1.01630048
49FGFR41.01537759
50TESK20.99732047
51WNK10.97690774
52CDC42BPA0.95737014
53* CDK50.95587252
54CAMK1G0.94811784
55GRK50.93467062
56MST1R0.89372783
57MARK20.88195199
58PTK20.86192486
59PRKCH0.83829740
60EPHB20.83680476
61CDK120.81972882
62ERN10.81892274
63STK110.79910701
64FER0.78027478
65CDK190.77650280
66DAPK10.76397159
67CDK70.75801735
68MAP3K100.75346459
69MAP3K110.74042973
70BUB10.73430307
71MET0.71754998
72AKT20.71300300
73MAP3K70.70680222
74MTOR0.68979236
75PRKCG0.67780741
76BMX0.67364152
77LIMK10.67132185
78CAMK10.66989913
79PTK60.66934541
80AURKA0.65852590
81MAP2K70.65194279
82PIM20.63506115
83PINK10.61096713
84* CDK140.61078674
85CAMK40.60278566
86MAP3K80.60232473
87* CDK150.60070458
88EPHB10.59946992
89BRSK10.59893859
90* CDK180.59868006
91SIK20.59284126
92IRAK20.59258230
93CAMK1D0.58973969
94PRKAA10.55926388
95PDPK10.55790580
96DYRK1B0.55458917
97MAP3K10.55281707
98MOS0.54862115
99TESK10.52239336
100* CDK11A0.52022801
101MAPK110.50834203
102PAK20.50649988
103PDK10.49890892
104SGK30.48817718
105LATS10.48791502
106MAP2K10.48719783
107RPS6KA20.48367628
108MAPKAPK30.48347277
109PRKD10.47567502
110SRPK10.47336171
111ERBB20.46209353
112MAP3K60.45536799
113MAP2K30.45373561
114CDK80.45333073
115CSNK1A1L0.45099097
116DAPK30.44325134
117MAPK100.44287793
118RPS6KA30.44076800
119CHEK20.43962464
120FGFR10.43515672
121CAMK2G0.42414306
122ILK0.41995305
123TTK0.41784851
124LRRK20.41439388
125ROCK10.41161216
126PRPF4B0.40959227
127CSNK1G30.40246640
128SIK10.40166875
129RPS6KL10.40147167
130RPS6KC10.40147167
131CHEK10.40137101
132SIK30.39858142
133PTK2B0.39662492
134MAPK130.38437464
135PAK40.37205590
136PRKD20.34530373
137SGK4940.34503875
138SGK2230.34503875

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.60574313
2Synaptic vesicle cycle_Homo sapiens_hsa047212.40783589
3Biosynthesis of amino acids_Homo sapiens_hsa012302.09164004
4Long-term potentiation_Homo sapiens_hsa047202.04997806
5Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.94679091
6Circadian entrainment_Homo sapiens_hsa047131.90007677
7Insulin secretion_Homo sapiens_hsa049111.81863551
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75489450
9GABAergic synapse_Homo sapiens_hsa047271.72566401
10Olfactory transduction_Homo sapiens_hsa047401.71983254
11Nicotine addiction_Homo sapiens_hsa050331.71574143
12Glutamatergic synapse_Homo sapiens_hsa047241.70519601
13Sulfur relay system_Homo sapiens_hsa041221.70518736
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65536651
15Gastric acid secretion_Homo sapiens_hsa049711.64273409
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63857923
17Pentose phosphate pathway_Homo sapiens_hsa000301.62720307
18Dopaminergic synapse_Homo sapiens_hsa047281.61732166
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58486222
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54632043
21Salivary secretion_Homo sapiens_hsa049701.54487386
22Amphetamine addiction_Homo sapiens_hsa050311.53048532
23Fructose and mannose metabolism_Homo sapiens_hsa000511.51775657
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49084997
25Dilated cardiomyopathy_Homo sapiens_hsa054141.48006428
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47912024
27Type II diabetes mellitus_Homo sapiens_hsa049301.47357680
28Oxytocin signaling pathway_Homo sapiens_hsa049211.45152749
29Cholinergic synapse_Homo sapiens_hsa047251.43281841
30GnRH signaling pathway_Homo sapiens_hsa049121.42789786
31Morphine addiction_Homo sapiens_hsa050321.40951212
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40926966
33Vibrio cholerae infection_Homo sapiens_hsa051101.40111283
34mTOR signaling pathway_Homo sapiens_hsa041501.38730373
35Glioma_Homo sapiens_hsa052141.37791231
36Carbon metabolism_Homo sapiens_hsa012001.36082340
37Nitrogen metabolism_Homo sapiens_hsa009101.35902038
38Gap junction_Homo sapiens_hsa045401.35776260
39Notch signaling pathway_Homo sapiens_hsa043301.34128825
40Prion diseases_Homo sapiens_hsa050201.34051344
41Estrogen signaling pathway_Homo sapiens_hsa049151.33836029
42Galactose metabolism_Homo sapiens_hsa000521.32127928
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28337797
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27218714
45Long-term depression_Homo sapiens_hsa047301.24278649
46Thyroid cancer_Homo sapiens_hsa052161.24037215
47Oocyte meiosis_Homo sapiens_hsa041141.20458426
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18728685
49Vitamin B6 metabolism_Homo sapiens_hsa007501.15392547
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15355079
51Cardiac muscle contraction_Homo sapiens_hsa042601.14273419
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12652933
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12636581
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11667096
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11654906
56Renin secretion_Homo sapiens_hsa049241.11321249
57Cocaine addiction_Homo sapiens_hsa050301.11056781
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09455257
59VEGF signaling pathway_Homo sapiens_hsa043701.09346177
60Endometrial cancer_Homo sapiens_hsa052131.08793657
61cAMP signaling pathway_Homo sapiens_hsa040241.08353066
62Neurotrophin signaling pathway_Homo sapiens_hsa047221.05307425
63ErbB signaling pathway_Homo sapiens_hsa040121.05058620
64Melanogenesis_Homo sapiens_hsa049161.03394019
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.03105304
66Calcium signaling pathway_Homo sapiens_hsa040201.03048586
67Insulin signaling pathway_Homo sapiens_hsa049101.02077204
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01846738
69Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01557948
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01408933
71Arginine and proline metabolism_Homo sapiens_hsa003300.99826032
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.99108376
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98979722
74Dorso-ventral axis formation_Homo sapiens_hsa043200.98889609
75Taste transduction_Homo sapiens_hsa047420.98725669
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98475451
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97555514
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.97401617
79Axon guidance_Homo sapiens_hsa043600.96810656
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96001163
81Glucagon signaling pathway_Homo sapiens_hsa049220.94101891
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92465619
83Pancreatic cancer_Homo sapiens_hsa052120.90785656
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90205278
85Lysine degradation_Homo sapiens_hsa003100.89105288
86Pancreatic secretion_Homo sapiens_hsa049720.88303766
87mRNA surveillance pathway_Homo sapiens_hsa030150.87748730
88Arginine biosynthesis_Homo sapiens_hsa002200.87111523
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86176311
90Thyroid hormone synthesis_Homo sapiens_hsa049180.83940294
91Renal cell carcinoma_Homo sapiens_hsa052110.83803888
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.82428239
93AMPK signaling pathway_Homo sapiens_hsa041520.82123953
94Hippo signaling pathway_Homo sapiens_hsa043900.81894078
95Non-small cell lung cancer_Homo sapiens_hsa052230.81082055
96MicroRNAs in cancer_Homo sapiens_hsa052060.80779402
97Tight junction_Homo sapiens_hsa045300.79403432
98DNA replication_Homo sapiens_hsa030300.78423942
99Acute myeloid leukemia_Homo sapiens_hsa052210.75883801
100Cell cycle_Homo sapiens_hsa041100.75323565
101Choline metabolism in cancer_Homo sapiens_hsa052310.75261432
102Endocytosis_Homo sapiens_hsa041440.74735850
103Focal adhesion_Homo sapiens_hsa045100.74426772
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74362681
105Proteoglycans in cancer_Homo sapiens_hsa052050.73909969
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72851525
107Small cell lung cancer_Homo sapiens_hsa052220.71058935
108ECM-receptor interaction_Homo sapiens_hsa045120.70711402
109Insulin resistance_Homo sapiens_hsa049310.70281322
110Other glycan degradation_Homo sapiens_hsa005110.68780507
111Hedgehog signaling pathway_Homo sapiens_hsa043400.68702291
112Colorectal cancer_Homo sapiens_hsa052100.66229245
113Base excision repair_Homo sapiens_hsa034100.66063169
114Rap1 signaling pathway_Homo sapiens_hsa040150.65023033
115MAPK signaling pathway_Homo sapiens_hsa040100.63550164
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.63072067
117HIF-1 signaling pathway_Homo sapiens_hsa040660.63011158
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62847024
119Serotonergic synapse_Homo sapiens_hsa047260.62838866
120Bladder cancer_Homo sapiens_hsa052190.60871703
121Chronic myeloid leukemia_Homo sapiens_hsa052200.60545789
122Wnt signaling pathway_Homo sapiens_hsa043100.60527417
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58530721
124Bile secretion_Homo sapiens_hsa049760.57596667
125Pyruvate metabolism_Homo sapiens_hsa006200.57588326
126Inositol phosphate metabolism_Homo sapiens_hsa005620.57477698
127Prostate cancer_Homo sapiens_hsa052150.57346220
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56805575
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56332909
130Circadian rhythm_Homo sapiens_hsa047100.54224084
131Phenylalanine metabolism_Homo sapiens_hsa003600.53176009
132Fatty acid biosynthesis_Homo sapiens_hsa000610.53140087
133Steroid biosynthesis_Homo sapiens_hsa001000.52106217
134N-Glycan biosynthesis_Homo sapiens_hsa005100.51882383
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.51424885
136Prolactin signaling pathway_Homo sapiens_hsa049170.51297591
137Spliceosome_Homo sapiens_hsa030400.51110306
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.50981418
139Amoebiasis_Homo sapiens_hsa051460.50709256
140Basal cell carcinoma_Homo sapiens_hsa052170.50402415
141Adherens junction_Homo sapiens_hsa045200.48685675
142Protein digestion and absorption_Homo sapiens_hsa049740.46911745
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46303378
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46023003

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