CDK15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in heart development (GO:0060973)5.62106886
2kidney mesenchyme development (GO:0072074)5.29031361
3regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.06064685
4collagen fibril organization (GO:0030199)5.05572015
5endocardial cushion development (GO:0003197)4.91930070
6metanephric mesenchyme development (GO:0072075)4.85567829
7positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.59644698
8protein heterotrimerization (GO:0070208)4.54102377
9regulation of timing of cell differentiation (GO:0048505)4.31145428
10regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.29892620
11pericardium development (GO:0060039)4.29853933
12chondrocyte proliferation (GO:0035988)4.28814463
13central nervous system myelination (GO:0022010)4.02655024
14axon ensheathment in central nervous system (GO:0032291)4.02655024
15limb bud formation (GO:0060174)4.01500702
16presynaptic membrane assembly (GO:0097105)3.92824877
17tachykinin receptor signaling pathway (GO:0007217)3.87093132
18mesenchymal-epithelial cell signaling (GO:0060638)3.86445471
19regulation of inositol phosphate biosynthetic process (GO:0010919)3.84944026
20bone trabecula formation (GO:0060346)3.81966927
21endodermal cell differentiation (GO:0035987)3.76878497
22inner ear receptor cell development (GO:0060119)3.70923207
23sequestering of extracellular ligand from receptor (GO:0035581)3.69494866
24negative regulation of homotypic cell-cell adhesion (GO:0034111)3.66463144
25regulation of development, heterochronic (GO:0040034)3.63394651
26skin morphogenesis (GO:0043589)3.63347324
27smooth muscle tissue development (GO:0048745)3.62207949
28presynaptic membrane organization (GO:0097090)3.57906774
29lymphangiogenesis (GO:0001946)3.56524440
30negative regulation of axon extension involved in axon guidance (GO:0048843)3.52102945
31embryonic forelimb morphogenesis (GO:0035115)3.51260853
32mesenchymal cell differentiation involved in renal system development (GO:2001012)3.50182014
33mesenchymal cell differentiation involved in kidney development (GO:0072161)3.50182014
34righting reflex (GO:0060013)3.47560295
35type B pancreatic cell proliferation (GO:0044342)3.43576486
36import into cell (GO:0098657)3.39785962
37regulation of platelet aggregation (GO:0090330)3.38330488
38L-amino acid import (GO:0043092)3.34423668
39endothelial cell morphogenesis (GO:0001886)3.34147345
40cell adhesion mediated by integrin (GO:0033627)3.33354899
41cellular response to vitamin (GO:0071295)3.32756471
42anterior/posterior axis specification, embryo (GO:0008595)3.32476937
43dermatan sulfate biosynthetic process (GO:0030208)3.31226208
44negative regulation of smooth muscle cell migration (GO:0014912)3.29805079
45keratinocyte development (GO:0003334)3.27900657
46retina layer formation (GO:0010842)3.26629243
47long-chain fatty acid biosynthetic process (GO:0042759)3.26537457
48cerebral cortex radially oriented cell migration (GO:0021799)3.26398821
49regulation of integrin-mediated signaling pathway (GO:2001044)3.25680681
50heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.24537556
51regulation of pigment cell differentiation (GO:0050932)3.22394949
52peptidyl-proline hydroxylation (GO:0019511)3.20696885
53neuron cell-cell adhesion (GO:0007158)3.19676582
54regulation of hippo signaling (GO:0035330)3.19048733
55cranial nerve morphogenesis (GO:0021602)3.18658278
56extracellular matrix assembly (GO:0085029)3.17983942
57cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.17036887
58postsynaptic membrane organization (GO:0001941)3.16399916
59positive regulation of protein kinase C signaling (GO:0090037)3.15672683
60protein hydroxylation (GO:0018126)3.14742350
61neuronal action potential propagation (GO:0019227)3.14336148
62positive regulation of blood vessel endothelial cell migration (GO:0043536)3.13687373
63chondrocyte development (GO:0002063)3.13498546
64substrate-dependent cell migration (GO:0006929)3.12768073
65regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.12247673
66negative regulation of axon guidance (GO:1902668)3.09937020
67forelimb morphogenesis (GO:0035136)3.09273236
68dermatan sulfate metabolic process (GO:0030205)3.08381669
69cellular response to vitamin D (GO:0071305)3.07808015
70embryonic cranial skeleton morphogenesis (GO:0048701)3.07525488
71negative regulation of stem cell proliferation (GO:2000647)3.05053156
72neural crest cell development (GO:0014032)3.04766214
73sprouting angiogenesis (GO:0002040)2.99259679
74cranial nerve development (GO:0021545)2.99045748
75negative regulation of osteoblast proliferation (GO:0033689)2.98699202
76cornea development in camera-type eye (GO:0061303)2.98135192
77positive regulation of fibroblast migration (GO:0010763)2.96229783
78ventricular septum development (GO:0003281)2.96133129
79substrate adhesion-dependent cell spreading (GO:0034446)2.93690921
80positive regulation of protein autophosphorylation (GO:0031954)2.92792482
81cell migration involved in sprouting angiogenesis (GO:0002042)2.91234851
82regulation of apoptotic process involved in morphogenesis (GO:1902337)2.89974418
83regulation of organ formation (GO:0003156)2.86888710
84virion attachment to host cell (GO:0019062)2.85616546
85adhesion of symbiont to host cell (GO:0044650)2.85616546
86positive regulation of cartilage development (GO:0061036)2.85287749
87G-protein coupled receptor internalization (GO:0002031)2.83924898
88fibroblast migration (GO:0010761)2.80301316
89negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.80171434
90regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.79198537
91male sex determination (GO:0030238)2.78885073
92short-term memory (GO:0007614)2.78516244
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78032075
94regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.77248775
95negative regulation of chondrocyte differentiation (GO:0032331)2.76360886
96negative regulation of protein localization to cell surface (GO:2000009)2.76236801
97ionotropic glutamate receptor signaling pathway (GO:0035235)2.75848381
98wound healing, spreading of epidermal cells (GO:0035313)2.75682347
99outer ear morphogenesis (GO:0042473)2.75265228
100hypotonic response (GO:0006971)2.75002434
101cochlea morphogenesis (GO:0090103)2.73739729
102reflex (GO:0060004)2.73330971
103actin filament depolymerization (GO:0030042)2.72585696
104developmental pigmentation (GO:0048066)2.71137667
105tooth mineralization (GO:0034505)2.70703241
106paraxial mesoderm development (GO:0048339)2.69910848
107activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.69817230
108positive regulation of fatty acid beta-oxidation (GO:0032000)2.69801681
109proteoglycan biosynthetic process (GO:0030166)2.69438148
110superoxide anion generation (GO:0042554)2.69377831
111positive regulation of axon extension (GO:0045773)2.66855033
112negative regulation of BMP signaling pathway (GO:0030514)2.65666505
113calcium ion import (GO:0070509)2.64164216
114response to magnesium ion (GO:0032026)2.64137129
115sympathetic nervous system development (GO:0048485)2.63872060
116organ growth (GO:0035265)2.63734194
117vascular endothelial growth factor signaling pathway (GO:0038084)2.62362939
118head development (GO:0060322)2.62022756
119amino acid import (GO:0043090)2.61817692
120neuron remodeling (GO:0016322)2.61062773
121protein heterotetramerization (GO:0051290)2.60378128
122positive regulation of uterine smooth muscle contraction (GO:0070474)2.59851622
123adenosine metabolic process (GO:0046085)2.59552572
124artery development (GO:0060840)2.58651235
125regulation of chondrocyte differentiation (GO:0032330)2.58461197
126mesodermal cell differentiation (GO:0048333)2.58431268
127regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.58014477
128opioid receptor signaling pathway (GO:0038003)2.57492562
129cellular response to epinephrine stimulus (GO:0071872)2.57270521
130positive regulation of action potential (GO:0045760)2.57090976
131regulation of axon extension involved in axon guidance (GO:0048841)2.56057965
132eyelid development in camera-type eye (GO:0061029)2.55712268
133glutamate receptor signaling pathway (GO:0007215)2.54991184
134retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54752579
135polyol transport (GO:0015791)2.54579496
136membrane raft organization (GO:0031579)2.53111572
137outflow tract septum morphogenesis (GO:0003148)2.52838471
138lateral sprouting from an epithelium (GO:0060601)2.52356503
139negative regulation of execution phase of apoptosis (GO:1900118)2.52267989
140glycoprotein biosynthetic process (GO:0009101)2.51652520
141photoreceptor cell differentiation (GO:0046530)2.51393330
142eye photoreceptor cell differentiation (GO:0001754)2.51393330
143face morphogenesis (GO:0060325)2.51334032
144protein retention in ER lumen (GO:0006621)2.50602002
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.50495530
146histone H2B ubiquitination (GO:0033523)2.48956216
147amino sugar catabolic process (GO:0046348)2.48589441
148collagen metabolic process (GO:0032963)2.48414295
149regulation of cartilage development (GO:0061035)2.47798014
150positive regulation of male gonad development (GO:2000020)2.46804534
151positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.45877920
152organ induction (GO:0001759)2.45867019
153photoreceptor cell maintenance (GO:0045494)2.44081464
154protein localization to synapse (GO:0035418)2.43198404
155spinal cord motor neuron differentiation (GO:0021522)2.42961322
156response to epinephrine (GO:0071871)2.42068273
157transmission of nerve impulse (GO:0019226)2.41281655
158cell proliferation in forebrain (GO:0021846)2.40320142
159cranial nerve structural organization (GO:0021604)2.39809628
160mesenchymal cell differentiation (GO:0048762)2.38757738
161mesonephros development (GO:0001823)2.38343942
162cerebral cortex cell migration (GO:0021795)2.37548964
163G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37339603
164cell morphogenesis involved in neuron differentiation (GO:0048667)2.36208526
165gamma-aminobutyric acid signaling pathway (GO:0007214)2.35187244
166startle response (GO:0001964)2.34056783
167otic vesicle formation (GO:0030916)2.33636452
168positive regulation of alcohol biosynthetic process (GO:1902932)2.33310761
169L-fucose catabolic process (GO:0042355)2.33223079
170fucose catabolic process (GO:0019317)2.33223079
171L-fucose metabolic process (GO:0042354)2.33223079
172peripheral nervous system neuron development (GO:0048935)2.32540384
173response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.30016258
174female gonad development (GO:0008585)2.27243280
175positive regulation of cellular amine metabolic process (GO:0033240)2.26294309
176cell-cell signaling involved in cell fate commitment (GO:0045168)2.25533505
177regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.25240680
178negative regulation of leukocyte chemotaxis (GO:0002689)2.24682217
179regulation of collateral sprouting (GO:0048670)2.24514480
180developmental induction (GO:0031128)2.24433629
181regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.24065250
182negative regulation of nitric-oxide synthase activity (GO:0051001)2.23991892
183regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.23030582
184regulation of homotypic cell-cell adhesion (GO:0034110)2.23024963
185positive regulation of meiosis (GO:0045836)2.21594834
186negative regulation of keratinocyte proliferation (GO:0010839)2.21404603
187negative regulation of platelet activation (GO:0010544)2.18720849
188thyroid gland development (GO:0030878)2.18687149
189positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.18069734
190neuronal action potential (GO:0019228)2.17872582
191oligodendrocyte differentiation (GO:0048709)2.17564876
192inner ear morphogenesis (GO:0042472)2.17540207
193cyclic nucleotide catabolic process (GO:0009214)2.17408667
194adult feeding behavior (GO:0008343)2.17272952
195forebrain neuron development (GO:0021884)2.16458946
196behavioral response to pain (GO:0048266)2.15527661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.89412669
2GBX2_23144817_ChIP-Seq_PC3_Human3.67194436
3EZH2_22144423_ChIP-Seq_EOC_Human3.66403764
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.25914865
5* BRD4_25478319_ChIP-Seq_HGPS_Human3.19346422
6CJUN_26792858_Chip-Seq_BT549_Human2.84625873
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74635773
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.55699844
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.51410486
10CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.50488844
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49970068
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.48915878
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46085535
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.34727197
15TAF15_26573619_Chip-Seq_HEK293_Human2.34012179
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31779052
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30047556
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25092267
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20721732
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.20519047
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19157492
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18903691
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18828544
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18828544
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.15878872
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15499619
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13755589
28VDR_22108803_ChIP-Seq_LS180_Human2.13673566
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05918722
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99086338
31* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93861737
32* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87257724
33* FLI1_27457419_Chip-Seq_LIVER_Mouse1.87066214
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86863723
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85230834
36JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83803300
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82861407
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82285016
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.81148576
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78853201
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78853201
42P300_19829295_ChIP-Seq_ESCs_Human1.78597644
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77972513
44IGF1R_20145208_ChIP-Seq_DFB_Human1.77134210
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.76599568
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75297700
47RNF2_27304074_Chip-Seq_NSC_Mouse1.74982690
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74711578
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74704368
50* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73847677
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73729643
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73281648
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71223440
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71209802
55AR_21572438_ChIP-Seq_LNCaP_Human1.67543374
56* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66912231
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66536880
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61320022
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.60546985
60* NFE2_27457419_Chip-Seq_LIVER_Mouse1.60460828
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.59942994
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59211626
63* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57395285
64* NANOG_18555785_Chip-Seq_ESCs_Mouse1.55499138
65* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55062854
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54952954
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52502544
68SMAD4_21799915_ChIP-Seq_A2780_Human1.51430758
69* E2F1_18555785_Chip-Seq_ESCs_Mouse1.47945393
70* EZH2_27294783_Chip-Seq_NPCs_Mouse1.47130910
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46365467
72* SMAD3_21741376_ChIP-Seq_EPCs_Human1.46065439
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45268417
74* P53_22387025_ChIP-Seq_ESCs_Mouse1.42799579
75* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.42105418
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40073709
77* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40024099
78* CMYC_18555785_Chip-Seq_ESCs_Mouse1.39618989
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35884055
80* STAT3_18555785_Chip-Seq_ESCs_Mouse1.35396705
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.35351165
82ER_23166858_ChIP-Seq_MCF-7_Human1.35323375
83TP53_18474530_ChIP-ChIP_U2OS_Human1.33257709
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33083326
85* P300_18555785_Chip-Seq_ESCs_Mouse1.32788469
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32097178
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.31960899
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30854198
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30381258
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30293323
91* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29987052
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29938524
93* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29012537
94TP53_20018659_ChIP-ChIP_R1E_Mouse1.27997865
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27172839
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26676949
97* NMYC_18555785_Chip-Seq_ESCs_Mouse1.25739933
98* OCT4_18555785_Chip-Seq_ESCs_Mouse1.23548270
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23466132
100REST_21632747_ChIP-Seq_MESCs_Mouse1.23188371
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23142746
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22980551
103BP1_19119308_ChIP-ChIP_Hs578T_Human1.22718140
104* SOX2_18555785_Chip-Seq_ESCs_Mouse1.22218189
105* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21676198
106ZNF274_21170338_ChIP-Seq_K562_Hela1.21363007
107TP53_16413492_ChIP-PET_HCT116_Human1.18812569
108JUN_21703547_ChIP-Seq_K562_Human1.18658487
109FUS_26573619_Chip-Seq_HEK293_Human1.18444407
110MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18403918
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18336074
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18225872
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18225872
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17089186
115* PU1_27457419_Chip-Seq_LIVER_Mouse1.17067404
116* KDM2B_26808549_Chip-Seq_REH_Human1.16976046
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.16132132
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14867682
119STAT3_23295773_ChIP-Seq_U87_Human1.13985145
120* KLF4_18555785_Chip-Seq_ESCs_Mouse1.13737711
121WT1_19549856_ChIP-ChIP_CCG9911_Human1.13067665
122TP53_23651856_ChIP-Seq_MEFs_Mouse1.12640506
123* RUNX2_22187159_ChIP-Seq_PCA_Human1.12198148
124* ZFX_18555785_Chip-Seq_ESCs_Mouse1.12091173
125SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11524109
126* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.11516070
127DROSHA_22980978_ChIP-Seq_HELA_Human1.11372350
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11151043
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.11092248
130SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10857973
131* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10479213
132RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10266584
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09917802
134TP63_23658742_ChIP-Seq_EP156T_Human1.09285316
135AHR_22903824_ChIP-Seq_MCF-7_Human1.09260506
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08785715
137AR_25329375_ChIP-Seq_VCAP_Human1.08654069
138* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07503123
139TCF4_23295773_ChIP-Seq_U87_Human1.05801686
140* CTCF_18555785_Chip-Seq_ESCs_Mouse1.05774159
141* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05362324
142* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05339614
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05060321
144NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02463316
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.99566307
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.96826500
147* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96261870
148RXR_22108803_ChIP-Seq_LS180_Human0.95912779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.81374233
2MP0003136_yellow_coat_color4.90152005
3MP0005503_abnormal_tendon_morphology4.81811787
4MP0002102_abnormal_ear_morphology3.87586479
5MP0001188_hyperpigmentation3.84350978
6MP0003705_abnormal_hypodermis_morpholog3.78562363
7MP0004272_abnormal_basement_membrane3.69167033
8MP0000566_synostosis3.63438082
9MP0001958_emphysema3.43221553
10MP0003279_aneurysm3.42456651
11MP0005409_darkened_coat_color3.37609009
12MP0006292_abnormal_olfactory_placode3.28448045
13MP0005275_abnormal_skin_tensile3.01358708
14MP0004381_abnormal_hair_follicle2.83827832
15MP0009780_abnormal_chondrocyte_physiolo2.78135254
16MP0003880_abnormal_central_pattern2.62895131
17MP0001968_abnormal_touch/_nociception2.53150103
18MP0009384_cardiac_valve_regurgitation2.52566092
19MP0001986_abnormal_taste_sensitivity2.47715441
20MP0002735_abnormal_chemical_nociception2.41249357
21MP0001542_abnormal_bone_strength2.38274008
22MP0005171_absent_coat_pigmentation2.35116544
23MP0008260_abnormal_autophagy2.31099086
24MP0004742_abnormal_vestibular_system2.24286395
25MP0010368_abnormal_lymphatic_system2.22339614
26MP0003566_abnormal_cell_adhesion2.22170651
27MP0001486_abnormal_startle_reflex2.14379381
28MP0006054_spinal_hemorrhage2.13350390
29MP0000534_abnormal_ureter_morphology2.10271015
30MP0000015_abnormal_ear_pigmentation2.03152244
31MP0005623_abnormal_meninges_morphology2.00654422
32MP0002277_abnormal_respiratory_mucosa2.00215964
33MP0005508_abnormal_skeleton_morphology2.00106344
34MP0002249_abnormal_larynx_morphology1.98274609
35MP0002736_abnormal_nociception_after1.96756387
36MP0005023_abnormal_wound_healing1.92721486
37MP0000569_abnormal_digit_pigmentation1.92012757
38MP0010030_abnormal_orbit_morphology1.77462965
39MP0000767_abnormal_smooth_muscle1.76169516
40MP0000751_myopathy1.72431811
41MP0003938_abnormal_ear_development1.67357544
42MP0003091_abnormal_cell_migration1.65996590
43MP0001661_extended_life_span1.62712531
44MP0009046_muscle_twitch1.57842209
45MP0000026_abnormal_inner_ear1.55121174
46MP0005645_abnormal_hypothalamus_physiol1.53489074
47MP0009745_abnormal_behavioral_response1.53115379
48MP0002272_abnormal_nervous_system1.52734144
49MP0000749_muscle_degeneration1.51575047
50MP0000049_abnormal_middle_ear1.51116415
51MP0009053_abnormal_anal_canal1.50563891
52MP0000733_abnormal_muscle_development1.50532613
53MP0002067_abnormal_sensory_capabilities1.50237667
54MP0001299_abnormal_eye_distance/1.49983447
55MP0003942_abnormal_urinary_system1.49948774
56MP0002734_abnormal_mechanical_nocicepti1.49823957
57MP0004142_abnormal_muscle_tone1.49474270
58MP0002108_abnormal_muscle_morphology1.48892344
59MP0005174_abnormal_tail_pigmentation1.45438985
60MP0005379_endocrine/exocrine_gland_phen1.44125535
61MP0001970_abnormal_pain_threshold1.44111789
62MP0001348_abnormal_lacrimal_gland1.41903376
63MP0006276_abnormal_autonomic_nervous1.40466681
64MP0000920_abnormal_myelination1.39830699
65MP0000013_abnormal_adipose_tissue1.39482721
66MP0005423_abnormal_somatic_nervous1.39129971
67MP0002896_abnormal_bone_mineralization1.39038856
68MP0009250_abnormal_appendicular_skeleto1.37495266
69MP0004270_analgesia1.35532529
70MP0002295_abnormal_pulmonary_circulatio1.34897219
71MP0001963_abnormal_hearing_physiology1.33699168
72MP0000631_abnormal_neuroendocrine_gland1.33561324
73MP0009379_abnormal_foot_pigmentation1.33508911
74MP0003950_abnormal_plasma_membrane1.33309971
75MP0005451_abnormal_body_composition1.31895543
76MP0008995_early_reproductive_senescence1.31057716
77MP0006072_abnormal_retinal_apoptosis1.30941347
78MP0002876_abnormal_thyroid_physiology1.30412448
79MP0005551_abnormal_eye_electrophysiolog1.29431376
80MP0003635_abnormal_synaptic_transmissio1.27977520
81MP0002733_abnormal_thermal_nociception1.26383544
82MP0005595_abnormal_vascular_smooth1.25782388
83MP0002060_abnormal_skin_morphology1.24409737
84MP0005197_abnormal_uvea_morphology1.22407305
85MP0003787_abnormal_imprinting1.21734770
86MP0000778_abnormal_nervous_system1.21508034
87MP0002064_seizures1.21149262
88MP0002184_abnormal_innervation1.20795472
89MP0002572_abnormal_emotion/affect_behav1.20562373
90MP0000759_abnormal_skeletal_muscle1.19740189
91MP0003724_increased_susceptibility_to1.19388489
92MP0002115_abnormal_skeleton_extremities1.18418338
93MP0001440_abnormal_grooming_behavior1.17547247
94MP0000003_abnormal_adipose_tissue1.15567309
95MP0002557_abnormal_social/conspecific_i1.14153492
96MP0001346_abnormal_lacrimal_gland1.13404674
97MP0010352_gastrointestinal_tract_polyps1.13247871
98MP0000163_abnormal_cartilage_morphology1.11606529
99MP0004859_abnormal_synaptic_plasticity1.11560185
100MP0000372_irregular_coat_pigmentation1.11271240
101MP0000428_abnormal_craniofacial_morphol1.10079102
102MP0003315_abnormal_perineum_morphology1.08261076
103MP0000538_abnormal_urinary_bladder1.07554317
104MP0002177_abnormal_outer_ear1.07002244
105MP0001485_abnormal_pinna_reflex1.06809078
106MP0001905_abnormal_dopamine_level1.06425841
107MP0002752_abnormal_somatic_nervous1.06071993
108MP0005646_abnormal_pituitary_gland1.02407515
109MP0004145_abnormal_muscle_electrophysio1.01993906
110MP0001984_abnormal_olfaction1.01000941
111MP0005257_abnormal_intraocular_pressure1.00188006
112MP0001243_abnormal_dermal_layer1.00063279
113MP0005390_skeleton_phenotype0.99829615
114MP0001501_abnormal_sleep_pattern0.98915982
115MP0001879_abnormal_lymphatic_vessel0.98487493
116MP0000681_abnormal_thyroid_gland0.98448948
117MP0005253_abnormal_eye_physiology0.97911657
118MP0000427_abnormal_hair_cycle0.97724402
119MP0005670_abnormal_white_adipose0.94632088
120MP0000383_abnormal_hair_follicle0.94628566
121MP0002751_abnormal_autonomic_nervous0.94460646
122MP0004134_abnormal_chest_morphology0.93008024
123MP0002109_abnormal_limb_morphology0.92494321
124MP0002168_other_aberrant_phenotype0.92367381
125MP0000762_abnormal_tongue_morphology0.91800286
126MP0005187_abnormal_penis_morphology0.90012064
127MP0002877_abnormal_melanocyte_morpholog0.89684492
128MP0003941_abnormal_skin_development0.89111157
129MP0002638_abnormal_pupillary_reflex0.88159135
130MP0002063_abnormal_learning/memory/cond0.87122404
131MP0002233_abnormal_nose_morphology0.85322541
132MP0002938_white_spotting0.84731807
133MP0001727_abnormal_embryo_implantation0.84482019
134MP0002882_abnormal_neuron_morphology0.84451974
135MP0002160_abnormal_reproductive_system0.83744933
136MP0003937_abnormal_limbs/digits/tail_de0.83010776
137MP0001664_abnormal_digestion0.82310004
138MP0002113_abnormal_skeleton_development0.81604691
139MP0010386_abnormal_urinary_bladder0.81230364
140MP0000432_abnormal_head_morphology0.80954076
141MP0005620_abnormal_muscle_contractility0.78355471
142MP0000579_abnormal_nail_morphology0.77786787
143MP0002098_abnormal_vibrissa_morphology0.77021328
144MP0002116_abnormal_craniofacial_bone0.76097238
145MP0003690_abnormal_glial_cell0.76015740
146MP0004233_abnormal_muscle_weight0.74721817
147MP0002114_abnormal_axial_skeleton0.74293779
148MP0001270_distended_abdomen0.73767281
149MP0000462_abnormal_digestive_system0.73679916
150MP0004084_abnormal_cardiac_muscle0.73341581
151MP0004036_abnormal_muscle_relaxation0.72766787
152MP0002932_abnormal_joint_morphology0.71872365
153MP0002128_abnormal_blood_circulation0.71760185
154MP0002837_dystrophic_cardiac_calcinosis0.71153485
155MP0002269_muscular_atrophy0.70926687
156MP0002163_abnormal_gland_morphology0.70643719
157MP0003385_abnormal_body_wall0.69826840
158MP0005395_other_phenotype0.69492791
159MP0000613_abnormal_salivary_gland0.68982421
160MP0002229_neurodegeneration0.68349586
161MP0002095_abnormal_skin_pigmentation0.68307603
162MP0003755_abnormal_palate_morphology0.67841222
163MP0003045_fibrosis0.65653367
164MP0003935_abnormal_craniofacial_develop0.65049968
165MP0001502_abnormal_circadian_rhythm0.65008503
166MP0003283_abnormal_digestive_organ0.64572252
167MP0005369_muscle_phenotype0.64049801
168MP0005193_abnormal_anterior_eye0.63756790
169MP0002332_abnormal_exercise_endurance0.63464752
170MP0005360_urolithiasis0.61940288
171MP0005195_abnormal_posterior_eye0.61485620
172MP0000230_abnormal_systemic_arterial0.61307183
173MP0002066_abnormal_motor_capabilities/c0.60509885
174MP0001614_abnormal_blood_vessel0.59100137
175MP0000371_diluted_coat_color0.56873438
176MP0005164_abnormal_response_to0.56460699
177MP0003718_maternal_effect0.55626519
178MP0000750_abnormal_muscle_regeneration0.54635274
179MP0006138_congestive_heart_failure0.51925774
180MP0003646_muscle_fatigue0.51896500
181MP0003252_abnormal_bile_duct0.50973074

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.00904515
2Protrusio acetabuli (HP:0003179)6.25698991
3Aortic dissection (HP:0002647)4.86853854
4Aortic aneurysm (HP:0004942)4.78049255
5Septo-optic dysplasia (HP:0100842)4.74827616
6Follicular hyperkeratosis (HP:0007502)4.58640870
7Soft skin (HP:0000977)4.52605144
8Type 1 muscle fiber predominance (HP:0003803)4.16798589
9Vascular tortuosity (HP:0004948)4.08884302
10Ankle contracture (HP:0006466)4.07684019
11Abnormality of dentin (HP:0010299)3.86753093
12Aplasia cutis congenita (HP:0001057)3.78906226
13Upper limb muscle weakness (HP:0003484)3.73906747
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.68044462
15Absent/shortened dynein arms (HP:0200106)3.68044462
16Arterial tortuosity (HP:0005116)3.54421597
17Bladder diverticulum (HP:0000015)3.52274892
18Spinal rigidity (HP:0003306)3.41864865
19Absent septum pellucidum (HP:0001331)3.38186023
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37724392
21White forelock (HP:0002211)3.35340911
22Spondylolisthesis (HP:0003302)3.30997028
23Focal motor seizures (HP:0011153)3.29686361
24Slender build (HP:0001533)3.28054609
25Wormian bones (HP:0002645)3.27878836
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.27678499
27Patchy hypopigmentation of hair (HP:0011365)3.23524158
28Shallow orbits (HP:0000586)3.21429655
29Abnormal ciliary motility (HP:0012262)3.20749117
30Coronal craniosynostosis (HP:0004440)3.14547522
31Nasolacrimal duct obstruction (HP:0000579)3.13821228
32Atrophic scars (HP:0001075)3.12457791
33Abnormality of the septum pellucidum (HP:0007375)3.04523011
34Neonatal short-limb short stature (HP:0008921)3.03972582
35Cervical subluxation (HP:0003308)3.00846518
36Mesomelia (HP:0003027)2.98582032
37Febrile seizures (HP:0002373)2.98033038
38Optic nerve hypoplasia (HP:0000609)2.94535641
39Parakeratosis (HP:0001036)2.92487889
40Abnormality of the lacrimal duct (HP:0011481)2.91520400
41Aplasia of the musculature (HP:0100854)2.90860633
42Fragile skin (HP:0001030)2.87679153
43Wrist flexion contracture (HP:0001239)2.86184859
44Broad metatarsal (HP:0001783)2.82839085
45Genu recurvatum (HP:0002816)2.80358823
46Syringomyelia (HP:0003396)2.79113584
47Spinal cord lesions (HP:0100561)2.79113584
48Popliteal pterygium (HP:0009756)2.77515282
49Elbow flexion contracture (HP:0002987)2.76933933
50Round ear (HP:0100830)2.73143132
51Chromsome breakage (HP:0040012)2.73124861
52Bowel diverticulosis (HP:0005222)2.73064164
53Blue sclerae (HP:0000592)2.72962845
54Congenital sensorineural hearing impairment (HP:0008527)2.71661402
55Mitral stenosis (HP:0001718)2.68568772
56Abnormal respiratory motile cilium physiology (HP:0012261)2.68293686
57Ulnar claw (HP:0001178)2.60802744
58Abnormality of the nasolacrimal system (HP:0000614)2.60187110
59Cardiovascular calcification (HP:0011915)2.59766954
60Decreased central vision (HP:0007663)2.59470981
61Tubulointerstitial nephritis (HP:0001970)2.58481678
62Hypoventilation (HP:0002791)2.56518970
63Prostate neoplasm (HP:0100787)2.55497891
64Prolonged neonatal jaundice (HP:0006579)2.53630898
65Abnormal respiratory epithelium morphology (HP:0012253)2.52949200
66Abnormal respiratory motile cilium morphology (HP:0005938)2.52949200
67Joint laxity (HP:0001388)2.52621025
68Morphological abnormality of the middle ear (HP:0008609)2.50156523
69Abnormality of incisor morphology (HP:0011063)2.49584720
70Conical tooth (HP:0000698)2.48618390
71Aortic regurgitation (HP:0001659)2.43180469
72Peritonitis (HP:0002586)2.42787272
73Duplicated collecting system (HP:0000081)2.42350137
74Wide anterior fontanel (HP:0000260)2.40546563
75Chin dimple (HP:0010751)2.37515398
76Short tibia (HP:0005736)2.36043855
77Attenuation of retinal blood vessels (HP:0007843)2.35918619
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34605881
79Overfolded helix (HP:0000396)2.32540711
80Osteomalacia (HP:0002749)2.32031791
81Abnormality of the renal collecting system (HP:0004742)2.30066326
82Lip pit (HP:0100267)2.29000635
83Hyperextensible skin (HP:0000974)2.28501344
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.27946460
85Dilatation of the ascending aorta (HP:0005111)2.27353349
86Aortic valve stenosis (HP:0001650)2.26769953
87Absent frontal sinuses (HP:0002688)2.26361998
88Hypophosphatemic rickets (HP:0004912)2.23527829
89Mildly elevated creatine phosphokinase (HP:0008180)2.23215116
90Congenital stationary night blindness (HP:0007642)2.22938742
91Long toe (HP:0010511)2.22733213
92Abnormality of the nasal septum (HP:0000419)2.22634332
93Mitral valve prolapse (HP:0001634)2.21618314
94Sex reversal (HP:0012245)2.20277305
95Abnormal sex determination (HP:0012244)2.20277305
96Metabolic alkalosis (HP:0200114)2.19286621
97Increased variability in muscle fiber diameter (HP:0003557)2.18492746
98Ulnar bowing (HP:0003031)2.17925263
99Abnormality of the axillary hair (HP:0100134)2.16061658
100Abnormality of secondary sexual hair (HP:0009888)2.16061658
101Duplication of thumb phalanx (HP:0009942)2.16061011
102Humeroradial synostosis (HP:0003041)2.16041827
103Synostosis involving the elbow (HP:0003938)2.16041827
104Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14333588
105Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.14267626
106Abnormality of the acetabulum (HP:0003170)2.13194516
107Hypomagnesemia (HP:0002917)2.13102116
108Mitral regurgitation (HP:0001653)2.12357290
109Hypoplastic scapulae (HP:0000882)2.11734047
110Aplasia/Hypoplasia of the scapulae (HP:0006713)2.11734047
111Aplasia involving bones of the upper limbs (HP:0009823)2.11540416
112Aplasia of the phalanges of the hand (HP:0009802)2.11540416
113Aplasia involving bones of the extremities (HP:0009825)2.11540416
114Abnormality of the phalanges of the hallux (HP:0010057)2.08182258
115Submucous cleft hard palate (HP:0000176)2.06418542
116Absent speech (HP:0001344)2.04581441
117Abnormal delivery (HP:0001787)2.03263940
118Short clavicles (HP:0000894)2.02272889
119Pulmonary artery stenosis (HP:0004415)2.01570813
120Nemaline bodies (HP:0003798)2.01090972
121Vertebral compression fractures (HP:0002953)2.00924558
122Fibular hypoplasia (HP:0003038)1.98647739
123Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97094169
124Biconcave vertebral bodies (HP:0004586)1.95915492
125Alacrima (HP:0000522)1.95862221
126Knee flexion contracture (HP:0006380)1.95539506
127Muscle fiber inclusion bodies (HP:0100299)1.94125702
128Xerostomia (HP:0000217)1.93709021
129Abnormality of the renal medulla (HP:0100957)1.93503929
130Cutaneous finger syndactyly (HP:0010554)1.93439794
131Abnormally folded helix (HP:0008544)1.93260782
132Atelectasis (HP:0100750)1.93206200
133Renal agenesis (HP:0000104)1.93008319
134Abnormality of the 2nd finger (HP:0004100)1.91977618
135Increased number of teeth (HP:0011069)1.91245321
136Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90868884
137Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87655917
138Partial duplication of thumb phalanx (HP:0009944)1.86479451
139Osteolytic defects of the hand bones (HP:0009699)1.86260896
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.86260896
141Progressive cerebellar ataxia (HP:0002073)1.85808006
142Ulnar deviation of the wrist (HP:0003049)1.85761370
143Craniofacial hyperostosis (HP:0004493)1.85670945
144Reduced subcutaneous adipose tissue (HP:0003758)1.84962440
145Abnormality of carpal bone ossification (HP:0006257)1.84711481
146Abnormality of proline metabolism (HP:0010907)1.84401145
147Hydroxyprolinuria (HP:0003080)1.84401145
148Abnormality of skeletal muscle fiber size (HP:0012084)1.83434276
149Short nail (HP:0001799)1.83292716
150Delayed gross motor development (HP:0002194)1.83227873
151Decreased lacrimation (HP:0000633)1.82533163
152Male pseudohermaphroditism (HP:0000037)1.82451192
153Neonatal respiratory distress (HP:0002643)1.82442404
154Ovoid vertebral bodies (HP:0003300)1.82218290
155Mild short stature (HP:0003502)1.82160917
156Vascular calcification (HP:0004934)1.81933120
157Hypothermia (HP:0002045)1.81546114
158Striae distensae (HP:0001065)1.80749165
159Abnormality of the parietal bone (HP:0002696)1.80551664
160Bell-shaped thorax (HP:0001591)1.80022085
161Renal duplication (HP:0000075)1.80014514
162Delayed closure of the anterior fontanelle (HP:0001476)1.79194755
163Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.78470669
164Deviation of the hallux (HP:0010051)1.77623831
165Mixed hearing impairment (HP:0000410)1.77510013
166Recurrent corneal erosions (HP:0000495)1.77264885
167Abnormality of calcium-phosphate metabolism (HP:0100530)1.77095407
168Onion bulb formation (HP:0003383)1.76948164
169Bradycardia (HP:0001662)1.76905199
170Deformed tarsal bones (HP:0008119)1.76115354
171Inguinal hernia (HP:0000023)1.75900477
172Aneurysm (HP:0002617)1.75214923
173Partial duplication of the phalanx of hand (HP:0009999)1.74947315
174Hypoplasia of the iris (HP:0007676)1.74778948
175Cupped ear (HP:0000378)1.74752083
176Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74578713
177Keratoconus (HP:0000563)1.74560241
178Increased corneal curvature (HP:0100692)1.74560241
179Limb-girdle muscle weakness (HP:0003325)1.74099594
180Overgrowth (HP:0001548)1.73230319
181Aplasia/Hypoplasia of the clavicles (HP:0006710)1.72906166
182Peripheral hypomyelination (HP:0007182)1.72687851
183Corneal dystrophy (HP:0001131)1.72160564
184Anomalous pulmonary venous return (HP:0010772)1.72122904
185Retinal dysplasia (HP:0007973)1.71792651
186Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71553018
187Degeneration of the lateral corticospinal tracts (HP:0002314)1.71553018
188Entropion (HP:0000621)1.71293432
189Cutaneous syndactyly (HP:0012725)1.71181471
190Amelogenesis imperfecta (HP:0000705)1.70735314
191Symphalangism affecting the phalanges of the hand (HP:0009773)1.70523365
192Hypoplasia of the fovea (HP:0007750)1.70414094
193Aplasia/Hypoplasia of the fovea (HP:0008060)1.70414094
194Camptodactyly of toe (HP:0001836)1.69471634
195Upper limb amyotrophy (HP:0009129)1.68859482
196Distal upper limb amyotrophy (HP:0007149)1.68859482
197Redundant skin (HP:0001582)1.68815781
198Delayed cranial suture closure (HP:0000270)1.66520496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.93280187
2MYLK4.86965512
3AKT34.49126436
4BLK4.30756284
5DDR23.63004106
6TTN3.38777955
7LATS13.36794385
8MKNK23.14322981
9FRK3.06646405
10TNIK2.87292733
11INSRR2.84414490
12PDGFRA2.73038537
13PTK22.69844268
14NEK92.46678915
15PIK3CG2.42890597
16LIMK12.42659163
17PAK22.38242929
18LATS22.34259290
19ADRBK22.16551464
20STK382.13326633
21NTRK12.12805551
22NTRK32.07659885
23GRK12.06156573
24ERBB41.96135960
25MAP3K131.84443575
26MOS1.81788008
27MAP3K141.81548519
28RIPK41.79244084
29ICK1.76607872
30PKN11.76467527
31IRAK11.65176137
32PTK2B1.63595554
33MUSK1.63148207
34GRK71.63100402
35MKNK11.57726308
36FLT31.52847563
37MET1.51691434
38BMPR1B1.43203375
39STK391.42642860
40NEK61.37589077
41BMPR21.35013546
42IRAK41.33008574
43IRAK21.32300469
44STK31.31661875
45FES1.27228702
46MAPK131.26082678
47EIF2AK21.25106695
48YES11.21657703
49IRAK31.21537255
50TXK1.21488056
51EPHA41.21468097
52PRPF4B1.16332250
53MAP3K31.13769684
54TGFBR21.12399297
55OXSR11.11872127
56FGR1.11082085
57MAP2K71.10383694
58MELK1.08786449
59ROCK11.05486212
60STK161.04176262
61STK38L1.03812504
62GRK51.02703359
63CLK11.01699618
64PBK1.01255650
65KIT1.00545958
66MAPKAPK30.99494770
67PAK60.95867482
68EPHA30.95554182
69PDGFRB0.93534053
70BCR0.93362012
71ILK0.93014822
72NEK20.91913653
73SIK10.90609039
74MAP2K10.90210034
75PAK30.89468121
76PRKG20.89033985
77MAPK150.88882816
78PRKCE0.87742233
79CDK30.85737396
80TNK20.85690740
81CSNK1A1L0.81919184
82TESK10.81474159
83EPHB20.81300323
84FER0.78997885
85CAMK2A0.78171793
86GSK3A0.78106355
87EPHB10.76005126
88CAMK2B0.73418899
89WNK10.72504207
90CDC42BPA0.72057736
91PNCK0.70462933
92PIK3CA0.69209183
93SIK20.68782003
94MST40.67887593
95CAMK1G0.66233569
96TAOK30.65078141
97NLK0.64935081
98MAP3K70.64269068
99TRIB30.62001610
100PRKD20.60493815
101PINK10.60471459
102ABL20.59784678
103CAMK2D0.59485157
104PRKCQ0.59249488
105CDK90.58591538
106CAMK10.57154655
107MST1R0.56683292
108CDK190.56257048
109PRKG10.56233049
110CHEK20.56213625
111MAPKAPK50.56114149
112CSNK1G10.55179088
113PAK40.54881900
114PHKG10.54863109
115PHKG20.54863109
116DYRK1A0.54198780
117NUAK10.54101294
118NTRK20.53347697
119MARK10.53308897
120MARK20.53278352
121PRKAA20.53074300
122PLK20.53060622
123ADRBK10.51568262
124WNK40.51499500
125MAP3K60.51468966
126CDK120.51442541
127CSNK1G30.51143288
128SRPK10.51076800
129TEC0.50931142
130PAK10.50523758
131MTOR0.49892140
132DYRK20.49468081
133MAPK70.49455223
134ARAF0.49434095
135ZAK0.49279282
136PRKD10.48902942
137CDK80.46282858
138AURKA0.45830934
139CSK0.45744411
140PRKACA0.45549011
141SGK4940.45384753
142SGK2230.45384753
143BUB10.45099023
144SIK30.45006942
145FYN0.44844052
146SGK10.43576543
147DMPK0.42168746
148TGFBR10.41361944
149TRPM70.41178187
150CDK70.40311603
151LYN0.40277676
152CAMK2G0.39386362
153CSNK1G20.39090879
154ROCK20.38425663
155ERBB30.37811405
156MAPK120.37295485
157RPS6KA20.37194477
158MAPK110.36519578
159MAP3K40.36497360
160PRKCH0.33565236
161MAPKAPK20.32189482
162UHMK10.32186641
163RIPK10.31970076
164TLK10.31750016
165PRKD30.30571681
166ABL10.29427745
167ACVR1B0.28918812
168INSR0.27933693
169DAPK30.26978844
170BRSK20.21971470

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.57273148
2Focal adhesion_Homo sapiens_hsa045102.94213670
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.86205768
4Nicotine addiction_Homo sapiens_hsa050332.85139696
5Phototransduction_Homo sapiens_hsa047442.77191362
6Taste transduction_Homo sapiens_hsa047422.31770697
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.31012955
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.18757941
9Morphine addiction_Homo sapiens_hsa050321.96841852
10Serotonergic synapse_Homo sapiens_hsa047261.96359798
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95934257
12Hippo signaling pathway_Homo sapiens_hsa043901.90499239
13Glutamatergic synapse_Homo sapiens_hsa047241.89702272
14Sphingolipid metabolism_Homo sapiens_hsa006001.82164352
15Proteoglycans in cancer_Homo sapiens_hsa052051.81903508
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79764799
17Ether lipid metabolism_Homo sapiens_hsa005651.74155348
18Protein digestion and absorption_Homo sapiens_hsa049741.71347474
19Amoebiasis_Homo sapiens_hsa051461.67577413
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62364387
21Adherens junction_Homo sapiens_hsa045201.56049417
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53900497
23TGF-beta signaling pathway_Homo sapiens_hsa043501.50754471
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48811859
25Axon guidance_Homo sapiens_hsa043601.46926325
26GABAergic synapse_Homo sapiens_hsa047271.43683430
27Calcium signaling pathway_Homo sapiens_hsa040201.40508257
28Salivary secretion_Homo sapiens_hsa049701.37802255
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.36738026
30Arachidonic acid metabolism_Homo sapiens_hsa005901.36643304
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.35687691
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35226992
33Graft-versus-host disease_Homo sapiens_hsa053321.28914960
34Small cell lung cancer_Homo sapiens_hsa052221.28383340
35Long-term depression_Homo sapiens_hsa047301.26034229
36Circadian entrainment_Homo sapiens_hsa047131.25616317
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24459107
38Rheumatoid arthritis_Homo sapiens_hsa053231.24227999
39Olfactory transduction_Homo sapiens_hsa047401.20739623
40Hedgehog signaling pathway_Homo sapiens_hsa043401.20024410
41Melanoma_Homo sapiens_hsa052181.19952885
42Basal cell carcinoma_Homo sapiens_hsa052171.19662672
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16224313
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14522998
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13625675
46Autoimmune thyroid disease_Homo sapiens_hsa053201.12445615
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11603888
48Fanconi anemia pathway_Homo sapiens_hsa034601.11382183
49Linoleic acid metabolism_Homo sapiens_hsa005911.11111866
50Gap junction_Homo sapiens_hsa045401.10144105
51MicroRNAs in cancer_Homo sapiens_hsa052061.07821174
52African trypanosomiasis_Homo sapiens_hsa051431.06315370
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06051407
54p53 signaling pathway_Homo sapiens_hsa041151.05129475
55Pathways in cancer_Homo sapiens_hsa052001.02504918
56Sulfur metabolism_Homo sapiens_hsa009201.01928115
57Collecting duct acid secretion_Homo sapiens_hsa049661.01504646
58Ras signaling pathway_Homo sapiens_hsa040140.99561728
59Fatty acid elongation_Homo sapiens_hsa000620.99008089
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98537181
61Insulin secretion_Homo sapiens_hsa049110.98397901
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98306644
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.96535595
64Cholinergic synapse_Homo sapiens_hsa047250.96506515
65Renin secretion_Homo sapiens_hsa049240.96177505
66Hematopoietic cell lineage_Homo sapiens_hsa046400.92979506
67Steroid biosynthesis_Homo sapiens_hsa001000.92816241
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92207061
69Allograft rejection_Homo sapiens_hsa053300.89466017
70Other glycan degradation_Homo sapiens_hsa005110.88536073
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88283942
72Basal transcription factors_Homo sapiens_hsa030220.86746642
73Oxytocin signaling pathway_Homo sapiens_hsa049210.85944965
74cAMP signaling pathway_Homo sapiens_hsa040240.85423218
75Thyroid hormone synthesis_Homo sapiens_hsa049180.84960329
76Platelet activation_Homo sapiens_hsa046110.84718281
77Gastric acid secretion_Homo sapiens_hsa049710.84575502
78Renin-angiotensin system_Homo sapiens_hsa046140.83802164
79Asthma_Homo sapiens_hsa053100.83672326
80Oxidative phosphorylation_Homo sapiens_hsa001900.83619214
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83528652
82Dorso-ventral axis formation_Homo sapiens_hsa043200.82957651
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82765740
84Mineral absorption_Homo sapiens_hsa049780.82472451
85Staphylococcus aureus infection_Homo sapiens_hsa051500.82309657
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80903876
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.80526963
88Ovarian steroidogenesis_Homo sapiens_hsa049130.79931536
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79036769
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.77757631
91Malaria_Homo sapiens_hsa051440.77493415
92Tight junction_Homo sapiens_hsa045300.77415095
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76306205
94Amphetamine addiction_Homo sapiens_hsa050310.75998417
95Glioma_Homo sapiens_hsa052140.75868508
96Dopaminergic synapse_Homo sapiens_hsa047280.73802773
97Pancreatic secretion_Homo sapiens_hsa049720.73531075
98Cardiac muscle contraction_Homo sapiens_hsa042600.72215394
99Selenocompound metabolism_Homo sapiens_hsa004500.71551826
100Lysine degradation_Homo sapiens_hsa003100.71278302
101Histidine metabolism_Homo sapiens_hsa003400.71105568
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70726784
103Phagosome_Homo sapiens_hsa041450.70368265
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70313095
105Retinol metabolism_Homo sapiens_hsa008300.69318500
106Bladder cancer_Homo sapiens_hsa052190.69075556
107Vitamin digestion and absorption_Homo sapiens_hsa049770.68641643
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68107075
109Thyroid cancer_Homo sapiens_hsa052160.68072743
110Wnt signaling pathway_Homo sapiens_hsa043100.67686016
111MAPK signaling pathway_Homo sapiens_hsa040100.66898273
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65637452
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64704680
114N-Glycan biosynthesis_Homo sapiens_hsa005100.64327088
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64009757
116Rap1 signaling pathway_Homo sapiens_hsa040150.63429519
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.60996031
118Prostate cancer_Homo sapiens_hsa052150.60313077
119Chemokine signaling pathway_Homo sapiens_hsa040620.60176389
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59167278
121Alzheimers disease_Homo sapiens_hsa050100.59026653
122Circadian rhythm_Homo sapiens_hsa047100.58609385
123Endocytosis_Homo sapiens_hsa041440.58084532
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.57564398
125Cocaine addiction_Homo sapiens_hsa050300.57508431
126Synaptic vesicle cycle_Homo sapiens_hsa047210.56378346
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55807943
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54992074
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.54508272
130Choline metabolism in cancer_Homo sapiens_hsa052310.53929866
131Type II diabetes mellitus_Homo sapiens_hsa049300.53377577
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53188455
133Melanogenesis_Homo sapiens_hsa049160.53088584
134Non-homologous end-joining_Homo sapiens_hsa034500.52672095
135ABC transporters_Homo sapiens_hsa020100.51957774
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50988353
137Dilated cardiomyopathy_Homo sapiens_hsa054140.50929490
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50142271
139Estrogen signaling pathway_Homo sapiens_hsa049150.49829035
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49194626
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48948161
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.46154750
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.46112842
144FoxO signaling pathway_Homo sapiens_hsa040680.44329178
145Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43322048
146GnRH signaling pathway_Homo sapiens_hsa049120.43213528
147Vibrio cholerae infection_Homo sapiens_hsa051100.42602791
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42473753
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41894042
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.40583709
151Homologous recombination_Homo sapiens_hsa034400.40343797
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40321713
153TNF signaling pathway_Homo sapiens_hsa046680.40277910
154Shigellosis_Homo sapiens_hsa051310.40257166

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