CDHR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the cadherin superfamily of calcium-dependent cell adhesion molecules. The encoded protein is a photoreceptor-specific cadherin that plays a role in outer segment disc morphogenesis. Mutations in this gene are associated with inherited retinal dystrophies. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* photoreceptor cell maintenance (GO:0045494)9.97171720
2establishment of skin barrier (GO:0061436)9.79519878
3retinal rod cell development (GO:0046548)9.67835229
4detection of light stimulus involved in sensory perception (GO:0050962)9.47648902
5detection of light stimulus involved in visual perception (GO:0050908)9.47648902
6desmosome organization (GO:0002934)8.99445503
7regulation of water loss via skin (GO:0033561)8.75123940
8phototransduction (GO:0007602)8.39292520
9detection of light stimulus (GO:0009583)8.09350754
10phototransduction, visible light (GO:0007603)8.07066546
11detection of visible light (GO:0009584)7.90330476
12keratinization (GO:0031424)7.81037598
13GMP metabolic process (GO:0046037)7.66795064
14visual perception (GO:0007601)7.44643938
15sensory perception of light stimulus (GO:0050953)7.37883776
16protein-chromophore linkage (GO:0018298)7.25798006
17multicellular organismal water homeostasis (GO:0050891)6.78939364
18photoreceptor cell differentiation (GO:0046530)6.19796341
19eye photoreceptor cell differentiation (GO:0001754)6.19796341
20positive regulation of guanylate cyclase activity (GO:0031284)6.16737420
21retina development in camera-type eye (GO:0060041)5.95900968
22keratinocyte proliferation (GO:0043616)5.86824352
23detection of external stimulus (GO:0009581)5.65839490
24detection of abiotic stimulus (GO:0009582)5.53381240
25regulation of guanylate cyclase activity (GO:0031282)5.52149186
26cellular response to light stimulus (GO:0071482)5.51226756
27water homeostasis (GO:0030104)5.48041192
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47571033
29bundle of His cell to Purkinje myocyte communication (GO:0086069)5.46024391
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.06662719
31intermediate filament organization (GO:0045109)4.93923412
32regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70035643
33hemidesmosome assembly (GO:0031581)4.66490227
34renal system process involved in regulation of blood volume (GO:0001977)4.57450109
35angiotensin maturation (GO:0002003)4.55610188
36nonmotile primary cilium assembly (GO:0035058)4.42567678
37peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.41648928
38regulation of clathrin-mediated endocytosis (GO:2000369)4.27763563
39synaptic vesicle maturation (GO:0016188)4.23842862
40keratinocyte differentiation (GO:0030216)4.23387428
41regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.13833584
42regulation of cGMP metabolic process (GO:0030823)4.12967876
43regulation of cholesterol homeostasis (GO:2000188)4.02231868
44epidermal cell differentiation (GO:0009913)3.96472280
45long-chain fatty acid biosynthetic process (GO:0042759)3.85588425
46positive regulation of cGMP biosynthetic process (GO:0030828)3.83060879
47sensory perception (GO:0007600)3.72391608
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.71910115
49linoleic acid metabolic process (GO:0043651)3.70337406
50adaptation of signaling pathway (GO:0023058)3.64435185
51response to pheromone (GO:0019236)3.60490376
52fat-soluble vitamin biosynthetic process (GO:0042362)3.56665039
53regulation of cGMP biosynthetic process (GO:0030826)3.56572322
54neuron development (GO:0048666)3.54361078
55phosphatidylserine acyl-chain remodeling (GO:0036150)3.53951162
56epidermis development (GO:0008544)3.51400547
57NADH metabolic process (GO:0006734)3.50717729
58molting cycle (GO:0042303)3.50431754
59hair cycle (GO:0042633)3.50431754
60sodium ion export (GO:0071436)3.49917702
61cellular response to radiation (GO:0071478)3.41170068
62regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.36481397
63protein localization to synapse (GO:0035418)3.33746696
64cellular potassium ion homeostasis (GO:0030007)3.32492531
65cell communication involved in cardiac conduction (GO:0086065)3.32455445
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.31319370
67positive regulation of cGMP metabolic process (GO:0030825)3.31019501
68L-amino acid import (GO:0043092)3.27913599
69regulation of synaptic vesicle exocytosis (GO:2000300)3.27525019
70epoxygenase P450 pathway (GO:0019373)3.24902218
71estrogen biosynthetic process (GO:0006703)3.24814652
72intestinal absorption (GO:0050892)3.21286397
73response to light stimulus (GO:0009416)3.20533686
74auditory receptor cell differentiation (GO:0042491)3.19765185
75regulation of type B pancreatic cell apoptotic process (GO:2000674)3.17315516
76renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.14983548
77regulation of voltage-gated calcium channel activity (GO:1901385)3.14305042
78peptidyl-tyrosine autophosphorylation (GO:0038083)3.14122036
79axon ensheathment in central nervous system (GO:0032291)3.13395320
80central nervous system myelination (GO:0022010)3.13395320
81retina layer formation (GO:0010842)3.12772310
82positive regulation of gastrulation (GO:2000543)3.12591644
83synaptic vesicle exocytosis (GO:0016079)3.12109989
84ventricular cardiac muscle cell action potential (GO:0086005)3.11726988
85postsynaptic membrane organization (GO:0001941)3.10888621
86innervation (GO:0060384)3.10841910
87potassium ion homeostasis (GO:0055075)3.09612067
88cytoskeletal anchoring at plasma membrane (GO:0007016)3.08623920
89positive regulation of vesicle fusion (GO:0031340)3.08578167
90detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.04739788
91membrane hyperpolarization (GO:0060081)3.03903222
92labyrinthine layer development (GO:0060711)3.03537946
93intermediate filament cytoskeleton organization (GO:0045104)3.02602348
94sodium ion homeostasis (GO:0055078)3.01436552
95chemosensory behavior (GO:0007635)3.00101071
96negative regulation of keratinocyte proliferation (GO:0010839)2.97198558
97regulation of bile acid biosynthetic process (GO:0070857)2.96929121
98axoneme assembly (GO:0035082)2.94276199
99regulation of heart rate by cardiac conduction (GO:0086091)2.93862515
100amino acid import (GO:0043090)2.90454871
101hair cell differentiation (GO:0035315)2.89731599
102positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.89650242
103phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.88986216
104lactate metabolic process (GO:0006089)2.87573704
105intermediate filament-based process (GO:0045103)2.87522505
106cGMP-mediated signaling (GO:0019934)2.85789732
107cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85308234
108lipid translocation (GO:0034204)2.85223409
109phospholipid translocation (GO:0045332)2.85223409
110very long-chain fatty acid metabolic process (GO:0000038)2.84989254
111phosphatidylinositol acyl-chain remodeling (GO:0036149)2.84079626
112epithelial cell-cell adhesion (GO:0090136)2.83105970
113receptor guanylyl cyclase signaling pathway (GO:0007168)2.82608026
114peptide cross-linking (GO:0018149)2.82229209
115negative regulation of receptor-mediated endocytosis (GO:0048261)2.81974829
116sulfate transmembrane transport (GO:1902358)2.81324858
117receptor recycling (GO:0001881)2.80745535
118trophectodermal cell differentiation (GO:0001829)2.79127966
119positive regulation of neurotransmitter transport (GO:0051590)2.78884732
120cell morphogenesis involved in neuron differentiation (GO:0048667)2.77313632
121inner ear receptor cell differentiation (GO:0060113)2.76901421
122cell-cell junction maintenance (GO:0045217)2.75419176
123phosphatidylcholine acyl-chain remodeling (GO:0036151)2.74819460
124regulation of systemic arterial blood pressure by hormone (GO:0001990)2.74459188
125regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.74459188
126endocrine process (GO:0050886)2.74459188
127regulation of synaptic vesicle transport (GO:1902803)2.73721237
128phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.72974010
129positive regulation of sodium ion transmembrane transport (GO:1902307)2.72629072
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72172653
131presynaptic membrane assembly (GO:0097105)2.69562584
132calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.69533896
133urea cycle (GO:0000050)2.68407999
134cardiac conduction (GO:0061337)2.68336766
135vitamin A metabolic process (GO:0006776)2.67699425
136cellular response to nitric oxide (GO:0071732)2.67071625
137positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.65160021
138potassium ion import (GO:0010107)2.65123304
139regulation of systemic arterial blood pressure (GO:0003073)2.64028726
140epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63691435
141behavioral response to ethanol (GO:0048149)2.60963361
142negative regulation of epidermal cell differentiation (GO:0045605)2.60956226
143regulation of vesicle fusion (GO:0031338)2.60420836
144protein prenylation (GO:0018342)2.59672491
145prenylation (GO:0097354)2.59672491
146appendage development (GO:0048736)2.58704210
147limb development (GO:0060173)2.58704210
148insulin secretion (GO:0030073)2.58132294
149glutamate secretion (GO:0014047)2.57819467
150response to histamine (GO:0034776)2.55835636
151intestinal epithelial cell development (GO:0060576)2.55428866
152negative regulation of myotube differentiation (GO:0010832)2.55374829
153COPI coating of Golgi vesicle (GO:0048205)2.52723040
154Golgi transport vesicle coating (GO:0048200)2.52723040
155vocalization behavior (GO:0071625)2.52560635
156regulation of calcium ion-dependent exocytosis (GO:0017158)2.52506930
157mitochondrion transport along microtubule (GO:0047497)2.51927477
158establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51927477
159long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.51260248
160synaptic vesicle endocytosis (GO:0048488)2.50552419
161fructose metabolic process (GO:0006000)2.49550292
162urea metabolic process (GO:0019627)2.49504664
163cell junction maintenance (GO:0034331)2.48674493
164embryonic process involved in female pregnancy (GO:0060136)2.47825426
165positive regulation of exocytosis (GO:0045921)2.47478646
166lipoprotein transport (GO:0042953)2.47437785
167negative regulation of epidermis development (GO:0045683)2.46784300
168diacylglycerol metabolic process (GO:0046339)2.46300112
169hormone catabolic process (GO:0042447)2.45957638
170epithelial cell fate commitment (GO:0072148)2.45652208
171cell communication by electrical coupling (GO:0010644)2.45401942
172macroautophagy (GO:0016236)2.44390314
173glandular epithelial cell differentiation (GO:0002067)2.43148775
174cellular sodium ion homeostasis (GO:0006883)2.42692169
175drug metabolic process (GO:0017144)2.42462627
176nitric oxide mediated signal transduction (GO:0007263)2.42365945
177sensory perception of smell (GO:0007608)2.41653569
178calcium ion import (GO:0070509)2.41497221
179apical protein localization (GO:0045176)2.41260407
180retinoid metabolic process (GO:0001523)2.41079328
181virion attachment to host cell (GO:0019062)2.39942342
182adhesion of symbiont to host cell (GO:0044650)2.39942342
183lateral sprouting from an epithelium (GO:0060601)2.39786947
184acidic amino acid transport (GO:0015800)2.38973961
185regulation of rhodopsin mediated signaling pathway (GO:0022400)12.9452265
186rhodopsin mediated signaling pathway (GO:0016056)12.6670602
187retinal cone cell development (GO:0046549)11.5779324
188photoreceptor cell development (GO:0042461)10.7257508
189eye photoreceptor cell development (GO:0042462)10.2317637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.57604352
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.23202230
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.04886248
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.70680938
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.59089161
6GBX2_23144817_ChIP-Seq_PC3_Human2.54525149
7DROSHA_22980978_ChIP-Seq_HELA_Human2.51317414
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.45524948
9REST_21632747_ChIP-Seq_MESCs_Mouse2.22835872
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.17317092
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07749317
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00620910
13EZH2_27294783_Chip-Seq_ESCs_Mouse1.96664404
14REST_18959480_ChIP-ChIP_MESCs_Mouse1.96270866
15SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96245320
16P63_26484246_Chip-Seq_KERATINOCYTES_Human1.94276454
17LXR_22292898_ChIP-Seq_THP-1_Human1.84554978
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84532867
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83567549
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.83131001
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82120702
22KDM2B_26808549_Chip-Seq_K562_Human1.79939271
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78961414
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74842032
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72402700
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.70054609
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68277842
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68277842
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.65976542
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64660389
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64568133
32P53_22127205_ChIP-Seq_FIBROBLAST_Human1.62017276
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.61394858
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61391641
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58408630
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57860353
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56997907
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55560206
39AR_19668381_ChIP-Seq_PC3_Human1.50602466
40* TP63_22573176_ChIP-Seq_HFKS_Human1.50379811
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.47947593
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47608451
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47240296
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.46392047
45EZH2_22144423_ChIP-Seq_EOC_Human1.45660757
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45255172
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41233404
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40420164
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38902362
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38346844
51SMAD3_21741376_ChIP-Seq_HESCs_Human1.38108877
52SMAD4_21799915_ChIP-Seq_A2780_Human1.37177051
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35765411
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34521271
55CTCF_27219007_Chip-Seq_Bcells_Human1.34304221
56RACK7_27058665_Chip-Seq_MCF-7_Human1.33145419
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.32829950
58IGF1R_20145208_ChIP-Seq_DFB_Human1.32803642
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31385193
60STAT3_23295773_ChIP-Seq_U87_Human1.31192945
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30023408
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29556333
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28016936
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28002607
65BCAT_22108803_ChIP-Seq_LS180_Human1.27790154
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26947593
67ZNF263_19887448_ChIP-Seq_K562_Human1.25828187
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25238161
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24817068
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24674551
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24238622
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23070888
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22348022
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21565246
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21320475
76VDR_22108803_ChIP-Seq_LS180_Human1.20127163
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18723781
78SMC4_20622854_ChIP-Seq_HELA_Human1.18355238
79KLF5_25053715_ChIP-Seq_YYC3_Human1.17798522
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.17526217
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17494188
82RXR_22108803_ChIP-Seq_LS180_Human1.17334144
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16969338
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15996396
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15738937
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15103184
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13883975
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.12955277
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12685576
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12402958
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12018178
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11846954
93SMAD4_21741376_ChIP-Seq_HESCs_Human1.10840387
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.10696384
95* GATA6_25053715_ChIP-Seq_YYC3_Human1.09770361
96AHR_22903824_ChIP-Seq_MCF-7_Human1.09115289
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09108132
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08239069
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08035437
100TBL1_22424771_ChIP-Seq_293T_Human1.07304537
101TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07011699
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.06751441
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.06657303
104JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06274933
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06164871
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05749782
107SMAD3_21741376_ChIP-Seq_ESCs_Human1.05182469
108SA1_27219007_Chip-Seq_Bcells_Human1.05163852
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04399362
110AR_21572438_ChIP-Seq_LNCaP_Human1.04002994
111WDR5_24793694_ChIP-Seq_LNCAP_Human1.03939622
112BCOR_27268052_Chip-Seq_Bcells_Human1.03828734
113P68_20966046_ChIP-Seq_HELA_Human1.03518374
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03172053
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.02591053
116SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01977599
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01658524
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01198252
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01145925
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00810248
121NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00510871
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99343715
123NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99203075
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99088736
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99032188
126EED_16625203_ChIP-ChIP_MESCs_Mouse0.98691852
127* GATA4_25053715_ChIP-Seq_YYC3_Human0.98571075
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98285143
129SA1_27219007_Chip-Seq_ERYTHROID_Human0.98230290
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.98049427
131TCF4_23295773_ChIP-Seq_U87_Human0.97975757
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97970310
133* CREB1_26743006_Chip-Seq_LNCaP_Human0.97321462
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.96643729
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96488860
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95612619
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.95458201
138OCT4_19829295_ChIP-Seq_ESCs_Human0.95367899
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94946040
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94819537
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94322074
142CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93382396
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.92919776
144* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91988918
145FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91616492
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91542047
147SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91208435
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91138122
149ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91098290
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90560309
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90372545
152BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90187794
153* CTCF_20526341_ChIP-Seq_ESCs_Human0.89786779
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88773761
155PIAS1_25552417_ChIP-Seq_VCAP_Human0.88563520
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88440051
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87822422
158KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87187428
159POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86088090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog8.59586215
2MP0003011_delayed_dark_adaptation8.41913346
3MP0006072_abnormal_retinal_apoptosis6.96191571
4MP0009379_abnormal_foot_pigmentation6.64018504
5MP0005253_abnormal_eye_physiology6.24386004
6MP0002796_impaired_skin_barrier6.05248607
7MP0010234_abnormal_vibrissa_follicle5.43127744
8MP0005275_abnormal_skin_tensile3.86536888
9* MP0005195_abnormal_posterior_eye3.64562834
10MP0000579_abnormal_nail_morphology3.62121317
11MP0000566_synostosis3.45820542
12MP0001324_abnormal_eye_pigmentation3.37844492
13MP0001188_hyperpigmentation3.35388612
14MP0005501_abnormal_skin_physiology3.34916426
15MP0005391_vision/eye_phenotype3.13620711
16MP0002822_catalepsy2.92520847
17MP0002090_abnormal_vision2.85478892
18MP0005409_darkened_coat_color2.79115924
19MP0002638_abnormal_pupillary_reflex2.64776003
20MP0003950_abnormal_plasma_membrane2.64756712
21MP0002653_abnormal_ependyma_morphology2.64110608
22MP0002229_neurodegeneration2.61974795
23MP0006292_abnormal_olfactory_placode2.47490798
24MP0002098_abnormal_vibrissa_morphology2.46923250
25MP0005360_urolithiasis2.45165890
26MP0003453_abnormal_keratinocyte_physiol2.23908148
27MP0001502_abnormal_circadian_rhythm2.18921357
28MP0001216_abnormal_epidermal_layer2.07290201
29MP0005499_abnormal_olfactory_system2.05411609
30MP0005394_taste/olfaction_phenotype2.05411609
31MP0004264_abnormal_extraembryonic_tissu2.04582284
32MP0008789_abnormal_olfactory_epithelium2.03067652
33MP0010678_abnormal_skin_adnexa1.97459138
34MP0002752_abnormal_somatic_nervous1.95548956
35MP0005423_abnormal_somatic_nervous1.94137592
36MP0001984_abnormal_olfaction1.86511529
37MP0003705_abnormal_hypodermis_morpholog1.81356793
38MP0000377_abnormal_hair_follicle1.74999990
39MP0000462_abnormal_digestive_system1.74669462
40MP0000383_abnormal_hair_follicle1.69566174
41MP0010771_integument_phenotype1.67356216
42MP0000537_abnormal_urethra_morphology1.65310951
43MP0001986_abnormal_taste_sensitivity1.62964195
44MP0002882_abnormal_neuron_morphology1.55374161
45MP0004947_skin_inflammation1.49811102
46MP0004270_analgesia1.49201475
47MP0004885_abnormal_endolymph1.48798893
48MP0001666_abnormal_nutrient_absorption1.45201360
49MP0000647_abnormal_sebaceous_gland1.43656054
50MP0000015_abnormal_ear_pigmentation1.41093726
51MP0004233_abnormal_muscle_weight1.34775196
52MP0002234_abnormal_pharynx_morphology1.34029994
53MP0004381_abnormal_hair_follicle1.33351874
54MP0000467_abnormal_esophagus_morphology1.28416301
55MP0010030_abnormal_orbit_morphology1.27735172
56MP0001764_abnormal_homeostasis1.24464171
57MP0003890_abnormal_embryonic-extraembry1.22115898
58MP0001485_abnormal_pinna_reflex1.21608085
59MP0009780_abnormal_chondrocyte_physiolo1.21052568
60MP0003941_abnormal_skin_development1.19852050
61MP0005085_abnormal_gallbladder_physiolo1.19804296
62MP0005174_abnormal_tail_pigmentation1.18859881
63MP0010352_gastrointestinal_tract_polyps1.17821148
64MP0002060_abnormal_skin_morphology1.17286138
65MP0002095_abnormal_skin_pigmentation1.16697820
66MP0005248_abnormal_Harderian_gland1.11272886
67MP0004043_abnormal_pH_regulation1.07308360
68MP0003123_paternal_imprinting1.06290706
69MP0010386_abnormal_urinary_bladder1.05915944
70MP0009931_abnormal_skin_appearance1.05541531
71MP0003283_abnormal_digestive_organ1.02815224
72MP0002909_abnormal_adrenal_gland1.02081548
73MP0002877_abnormal_melanocyte_morpholog1.01801475
74MP0003329_amyloid_beta_deposits0.98382925
75MP0005670_abnormal_white_adipose0.97629995
76MP0001664_abnormal_digestion0.97309956
77MP0000477_abnormal_intestine_morphology0.92465833
78MP0001486_abnormal_startle_reflex0.91745180
79MP0005365_abnormal_bile_salt0.91579800
80MP0003635_abnormal_synaptic_transmissio0.90555464
81MP0001765_abnormal_ion_homeostasis0.89989890
82MP0001346_abnormal_lacrimal_gland0.89754488
83MP0005187_abnormal_penis_morphology0.89359660
84MP0002734_abnormal_mechanical_nocicepti0.89048679
85MP0004019_abnormal_vitamin_homeostasis0.88870944
86MP0005197_abnormal_uvea_morphology0.88344710
87MP0003634_abnormal_glial_cell0.87673291
88MP0001944_abnormal_pancreas_morphology0.87126949
89MP0002127_abnormal_cardiovascular_syste0.86055698
90MP0000367_abnormal_coat/_hair0.85658174
91MP0000631_abnormal_neuroendocrine_gland0.85260294
92MP0000762_abnormal_tongue_morphology0.85194674
93MP0002139_abnormal_hepatobiliary_system0.84782578
94MP0002272_abnormal_nervous_system0.83967441
95MP0004859_abnormal_synaptic_plasticity0.82241698
96MP0004147_increased_porphyrin_level0.78172652
97MP0002089_abnormal_postnatal_growth/wei0.77869544
98MP0001849_ear_inflammation0.76541841
99MP0002693_abnormal_pancreas_physiology0.76272613
100MP0003866_abnormal_defecation0.76087582
101MP0002009_preneoplasia0.74429121
102MP0005220_abnormal_exocrine_pancreas0.74230238
103MP0002249_abnormal_larynx_morphology0.71352556
104MP0002064_seizures0.71007828
105MP0000427_abnormal_hair_cycle0.70817763
106MP0009840_abnormal_foam_cell0.69855869
107MP0003119_abnormal_digestive_system0.69676504
108MP0004782_abnormal_surfactant_physiolog0.68524073
109MP0002184_abnormal_innervation0.67961786
110MP0000490_abnormal_crypts_of0.67637080
111MP0005377_hearing/vestibular/ear_phenot0.65392281
112MP0003878_abnormal_ear_physiology0.65392281
113MP0001286_abnormal_eye_development0.65376054
114MP0002063_abnormal_learning/memory/cond0.65305431
115MP0002697_abnormal_eye_size0.64173990
116MP0005645_abnormal_hypothalamus_physiol0.64108996
117MP0005666_abnormal_adipose_tissue0.62279101
118MP0001293_anophthalmia0.61306172
119MP0003868_abnormal_feces_composition0.60778138
120MP0000013_abnormal_adipose_tissue0.60061469
121MP0003183_abnormal_peptide_metabolism0.59328473
122MP0001501_abnormal_sleep_pattern0.59191308
123MP0002067_abnormal_sensory_capabilities0.58344897
124MP0001191_abnormal_skin_condition0.56948287
125MP0000778_abnormal_nervous_system0.54213135
126MP0004858_abnormal_nervous_system0.54148213
127MP0001963_abnormal_hearing_physiology0.53574768
128MP0000538_abnormal_urinary_bladder0.53282888
129MP0003690_abnormal_glial_cell0.53149758
130MP0002928_abnormal_bile_duct0.52471395
131MP0002111_abnormal_tail_morphology0.52208948
132MP0002078_abnormal_glucose_homeostasis0.52165621
133MP0002572_abnormal_emotion/affect_behav0.50977726
134MP0003315_abnormal_perineum_morphology0.50464673
135MP0004215_abnormal_myocardial_fiber0.49752849
136MP0001440_abnormal_grooming_behavior0.49745082
137MP0004811_abnormal_neuron_physiology0.48925688
138MP0009046_muscle_twitch0.47228466
139MP0002152_abnormal_brain_morphology0.47132164
140MP0000003_abnormal_adipose_tissue0.46223422
141MP0003880_abnormal_central_pattern0.45511359
142MP0003045_fibrosis0.44831830
143MP0005386_behavior/neurological_phenoty0.44813080
144MP0004924_abnormal_behavior0.44813080
145MP0008569_lethality_at_weaning0.44352493
146MP0002332_abnormal_exercise_endurance0.43801420
147MP0009745_abnormal_behavioral_response0.43373859
148MP0000955_abnormal_spinal_cord0.42017327
149MP0002557_abnormal_social/conspecific_i0.41587924
150MP0005646_abnormal_pituitary_gland0.40838511
151MP0008961_abnormal_basal_metabolism0.39599231
152MP0004145_abnormal_muscle_electrophysio0.38585596
153MP0003787_abnormal_imprinting0.38264025
154MP0003633_abnormal_nervous_system0.36755675
155MP0004085_abnormal_heartbeat0.36459869
156MP0002066_abnormal_motor_capabilities/c0.36390871
157MP0002751_abnormal_autonomic_nervous0.35831259
158MP0005257_abnormal_intraocular_pressure0.35819985
159MP0002069_abnormal_eating/drinking_beha0.35615188
160MP0003879_abnormal_hair_cell0.33087429
161MP0004742_abnormal_vestibular_system0.31583770
162MP0000678_abnormal_parathyroid_gland0.30576534
163MP0001970_abnormal_pain_threshold0.30495859
164MP0003861_abnormal_nervous_system0.30463790
165MP0008775_abnormal_heart_ventricle0.30375951
166MP0003953_abnormal_hormone_level0.28680399
167MP0000428_abnormal_craniofacial_morphol0.28675450
168MP0005076_abnormal_cell_differentiation0.27662649

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.91556849
2Abnormal rod and cone electroretinograms (HP:0008323)9.85875598
3Central scotoma (HP:0000603)9.14171596
4Pendular nystagmus (HP:0012043)8.40872805
5Chorioretinal atrophy (HP:0000533)7.88243097
6Abnormality of macular pigmentation (HP:0008002)7.79868498
7Abolished electroretinogram (ERG) (HP:0000550)7.63702305
8Scotoma (HP:0000575)7.54732007
9Pigmentary retinal degeneration (HP:0001146)7.34699141
10Dyschromatopsia (HP:0007641)7.12000925
11Attenuation of retinal blood vessels (HP:0007843)6.51530075
12Decreased central vision (HP:0007663)6.41250769
13Severe visual impairment (HP:0001141)6.33488395
14Posterior subcapsular cataract (HP:0007787)6.24089117
15Palmoplantar hyperkeratosis (HP:0000972)5.71069663
16Increased IgE level (HP:0003212)5.69731650
17Palmar hyperkeratosis (HP:0010765)5.43030679
18Plantar hyperkeratosis (HP:0007556)5.25343194
19* Type II diabetes mellitus (HP:0005978)5.17949609
20Cone-rod dystrophy (HP:0000548)5.09928745
21Increased corneal curvature (HP:0100692)5.06285224
22Keratoconus (HP:0000563)5.06285224
23Macular degeneration (HP:0000608)5.03562434
24* Photophobia (HP:0000613)4.94370233
25Hypotrichosis (HP:0001006)4.58874269
26Constricted visual fields (HP:0001133)4.58785066
27Abnormality of nail color (HP:0100643)4.52413325
28Erythroderma (HP:0001019)4.51119013
29Right ventricular cardiomyopathy (HP:0011663)4.46625207
30Congenital ichthyosiform erythroderma (HP:0007431)4.40310238
31Vitreoretinal degeneration (HP:0000655)4.39933502
32Alopecia of scalp (HP:0002293)4.39278478
33Pili torti (HP:0003777)4.26883602
34Woolly hair (HP:0002224)4.13337995
35Conjunctival hamartoma (HP:0100780)4.03629819
36Erythema (HP:0010783)3.98840522
37Fragile nails (HP:0001808)3.96444511
38Retinitis pigmentosa (HP:0000510)3.76958854
39Subcapsular cataract (HP:0000523)3.75315846
40Abnormality of secondary sexual hair (HP:0009888)3.74591684
41Abnormality of the axillary hair (HP:0100134)3.74591684
42Onycholysis (HP:0001806)3.65037785
43Abnormality of glutamine family amino acid metabolism (HP:0010902)3.62350555
44Abnormal hair laboratory examination (HP:0003328)3.58841519
45Choroideremia (HP:0001139)3.52679217
46Thick nail (HP:0001805)3.48988885
47Split foot (HP:0001839)3.42933508
48Hyperactive renin-angiotensin system (HP:0000841)3.42780200
49Abnormality of the salivary glands (HP:0010286)3.16493733
50Metabolic alkalosis (HP:0200114)3.08168718
51Malnutrition (HP:0004395)3.07787988
52Hamartoma of the eye (HP:0010568)2.96324940
53Congenital sensorineural hearing impairment (HP:0008527)2.94483437
54Abnormal blistering of the skin (HP:0008066)2.91973444
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.90146677
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.89560678
57Abnormality of renin-angiotensin system (HP:0000847)2.86286275
58Milia (HP:0001056)2.85941685
59Corneal erosion (HP:0200020)2.81822559
60Aplasia involving bones of the extremities (HP:0009825)2.79275490
61Aplasia involving bones of the upper limbs (HP:0009823)2.79275490
62Aplasia of the phalanges of the hand (HP:0009802)2.79275490
63Hydroxyprolinuria (HP:0003080)2.67595455
64Abnormality of proline metabolism (HP:0010907)2.67595455
65Palmoplantar keratoderma (HP:0000982)2.61965575
66Depressed nasal tip (HP:0000437)2.61086547
67Decreased circulating renin level (HP:0003351)2.57987517
68Retinal atrophy (HP:0001105)2.52156996
69Abnormality of the distal phalanx of the thumb (HP:0009617)2.51060278
70* Progressive visual loss (HP:0000529)2.49625646
71Ankle clonus (HP:0011448)2.47580753
72Ileus (HP:0002595)2.35162364
73Megalencephaly (HP:0001355)2.34580461
74Eczematoid dermatitis (HP:0000976)2.31333532
75Gait imbalance (HP:0002141)2.30186538
76Confusion (HP:0001289)2.29485132
77Congenital primary aphakia (HP:0007707)2.25903976
78Sparse scalp hair (HP:0002209)2.25685018
79Absent eyelashes (HP:0000561)2.18868479
80* Wide nasal bridge (HP:0000431)2.17783619
81Abnormality of the dental root (HP:0006486)2.15771642
82Taurodontia (HP:0000679)2.15771642
83Abnormality of permanent molar morphology (HP:0011071)2.15771642
84Germ cell neoplasia (HP:0100728)2.15181669
85Hypoplastic labia majora (HP:0000059)2.14832201
86Myokymia (HP:0002411)2.12451361
87Nasolacrimal duct obstruction (HP:0000579)2.10019858
88Hamartoma (HP:0010566)2.09527813
89Nail dystrophy (HP:0008404)2.08546954
90Ventricular fibrillation (HP:0001663)2.07026401
91Pancreatic fibrosis (HP:0100732)2.03686105
92Widely patent fontanelles and sutures (HP:0004492)2.02936144
93Curly hair (HP:0002212)2.02545000
94Abnormality of the gastric mucosa (HP:0004295)2.02164853
95Bronchomalacia (HP:0002780)2.01781404
96Hyperparathyroidism (HP:0000843)2.01102043
97Polar cataract (HP:0010696)2.00367748
98Congenital stationary night blindness (HP:0007642)11.8369882
99Absent rod-and cone-mediated responses on ERG (HP:0007688)10.3392937
100Hyperaldosteronism (HP:0000859)1.99421395
101Nephrogenic diabetes insipidus (HP:0009806)1.98997947
102Abnormality of the vitamin B12 metabolism (HP:0004341)1.98827541
103Neonatal short-limb short stature (HP:0008921)1.98627159
104Hypohidrosis (HP:0000966)1.97808286
105Optic disc pallor (HP:0000543)1.95639815
106Medial flaring of the eyebrow (HP:0010747)1.95561582
107Partial duplication of thumb phalanx (HP:0009944)1.95486264
108Septate vagina (HP:0001153)1.94624720
109Abnormality of molar (HP:0011077)1.94365570
110Abnormality of molar morphology (HP:0011070)1.94365570
111True hermaphroditism (HP:0010459)1.94357655
112Hyperglycinuria (HP:0003108)1.93640798
113Abnormality of the dental pulp (HP:0006479)1.93006424
114Ridged nail (HP:0001807)1.92565381
115Hypoplasia of the fovea (HP:0007750)1.92035210
116Aplasia/Hypoplasia of the fovea (HP:0008060)1.92035210
117Hypoplasia of dental enamel (HP:0006297)1.90570508
118Advanced eruption of teeth (HP:0006288)1.89487710
119Lip pit (HP:0100267)1.89037471
120Abnormality of the fovea (HP:0000493)1.89035434
121Dehydration (HP:0001944)1.88864623
122Abnormality of chloride homeostasis (HP:0011422)1.88792481
123Sparse eyelashes (HP:0000653)1.88726369
124Xerostomia (HP:0000217)1.88115940
125Abnormality of the labia majora (HP:0012881)1.87599907
126Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.87394034
127Alacrima (HP:0000522)1.85967610
128Cystic liver disease (HP:0006706)1.83358911
129Slow-growing hair (HP:0002217)1.82903263
130Abnormality of hair growth rate (HP:0011363)1.82903263
131Abnormality of the lacrimal duct (HP:0011481)1.81262292
132Esophageal atresia (HP:0002032)1.79512226
133Alkalosis (HP:0001948)1.78876471
134Visceral angiomatosis (HP:0100761)1.77503638
135Melanocytic nevus (HP:0000995)1.75942852
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.75556743
137Abnormality of vitamin B metabolism (HP:0004340)1.72810615
138Acanthosis nigricans (HP:0000956)1.72433096
139Laryngomalacia (HP:0001601)1.70886924
140Poor coordination (HP:0002370)1.70016889
141Neonatal death (HP:0003811)1.69842938
142Visual hallucinations (HP:0002367)1.69462789
143Syncope (HP:0001279)1.67441900
144Pancreatic cysts (HP:0001737)1.62510710
145Vaginal atresia (HP:0000148)1.57485007
146Severe Myopia (HP:0011003)1.55198227
147Genital tract atresia (HP:0001827)1.54931711
148Interstitial pulmonary disease (HP:0006530)1.54019764
149Epileptic encephalopathy (HP:0200134)1.53765214
150Septo-optic dysplasia (HP:0100842)1.53696379
151* Optic atrophy (HP:0000648)1.47621817
152Aplasia/Hypoplasia of the lens (HP:0008063)1.47605409
153Horizontal nystagmus (HP:0000666)1.46694669
154Aplasia/Hypoplasia of the macula (HP:0008059)1.44416861
155Sclerocornea (HP:0000647)1.43662724
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.40266113
157Aplasia/Hypoplasia affecting the retina (HP:0008061)1.38434032
158Macroorchidism (HP:0000053)1.36650422
159Febrile seizures (HP:0002373)1.28117130
160Dysdiadochokinesis (HP:0002075)1.19265910
161Genetic anticipation (HP:0003743)1.18604360
162Furrowed tongue (HP:0000221)1.18186223
163Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.15612543
164Hyperinsulinemic hypoglycemia (HP:0000825)1.12782701
165Abdominal situs inversus (HP:0003363)1.10250707
166Abnormality of abdominal situs (HP:0011620)1.10250707
167Insomnia (HP:0100785)1.09129461
168Abnormality of midbrain morphology (HP:0002418)1.08633377
169Molar tooth sign on MRI (HP:0002419)1.08633377
170Progressive cerebellar ataxia (HP:0002073)1.06478498
171Chorioretinal coloboma (HP:0000567)1.05561222
172Prolonged QT interval (HP:0001657)1.04088993
173Left ventricular hypertrophy (HP:0001712)1.03682596
174Hypoglycemic seizures (HP:0002173)1.03287768
175Truncal ataxia (HP:0002078)1.02669706
176Hypermetropia (HP:0000540)1.01821774
177Abnormality of the parathyroid morphology (HP:0011766)1.00687052
178Depression (HP:0000716)1.00360332
179Astigmatism (HP:0000483)0.98746554
180Specific learning disability (HP:0001328)0.96636636
181Retinal detachment (HP:0000541)0.93395110
182Supranuclear gaze palsy (HP:0000605)0.93087498
183Congenital hepatic fibrosis (HP:0002612)0.91631857
184Anencephaly (HP:0002323)0.91430817
185Insulin-resistant diabetes mellitus (HP:0000831)0.90712598
186Abnormality of the pancreatic islet cells (HP:0006476)0.88377181
187Abnormality of endocrine pancreas physiology (HP:0012093)0.88377181
188Postaxial hand polydactyly (HP:0001162)0.87362151
189Anophthalmia (HP:0000528)0.87144522
190Elfin facies (HP:0004428)0.86218722
191Abnormality of dental color (HP:0011073)0.86070958
192Abnormality of the lower motor neuron (HP:0002366)0.85415813
193Decreased testicular size (HP:0008734)0.85345761
194Broad foot (HP:0001769)0.84774093
195EEG with generalized epileptiform discharges (HP:0011198)0.83643155
196Abnormal EKG (HP:0003115)0.83508588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK17.29062326
2LMTK24.91251796
3INSRR3.78242481
4EEF2K3.60341559
5MST1R3.10564475
6IRAK23.01057126
7EPHA42.79803410
8MAP3K102.70115965
9HIPK22.65522013
10ACVR1B2.48871665
11EPHB22.32995404
12CASK2.22148997
13STK242.11851169
14SMG12.06699456
15EPHA22.03546518
16PINK12.02227276
17CAMK1G1.94958324
18PAK61.91848328
19SCYL21.80560070
20PRKD31.80028695
21MARK11.75837196
22MAP3K21.69980481
23FGFR21.64648584
24MAP3K61.62543320
25BRD41.61179242
26SGK2231.61113801
27SGK4941.61113801
28MET1.60560350
29TGFBR11.56511687
30ICK1.55715213
31CAMK1D1.55260589
32DYRK1B1.52412841
33MAP3K41.49540473
34DYRK1A1.48599754
35PRKG21.48535109
36STK391.47312565
37SIK21.43975882
38NTRK31.43389160
39FGFR11.41396719
40ERBB21.41281066
41MAPK151.40346585
42FGFR41.40256993
43PASK1.39624212
44TYRO31.38595521
45TAOK31.37400839
46PBK1.36284481
47STK381.28911052
48PRKCH1.27112514
49FRK1.25580253
50NEK11.24345397
51ERBB31.16227875
52AKT31.15006981
53PIK3CA1.14068751
54CDC42BPA1.13916968
55ADRBK11.13554999
56CDK121.12527093
57MAPKAPK31.11809778
58MARK21.09310434
59SGK21.05545709
60WNK11.04022638
61FGFR31.01919870
62PNCK0.97049298
63SIK10.95363813
64SGK30.94992676
65OXSR10.92143910
66PRPF4B0.89497159
67MAPK70.88758595
68PRKAA10.88437816
69DMPK0.87982350
70PTK60.86609105
71PRKD20.85992004
72CDK30.85769055
73KSR20.85296936
74CAMK2D0.83419008
75BMX0.82546451
76CDK50.81715418
77RET0.81419435
78GRK50.80879400
79TRIB30.80859679
80ERN10.80688218
81PHKG10.80166813
82PHKG20.80166813
83LATS10.79713691
84CDK90.79377467
85CAMKK10.78432063
86WNK40.77808031
87CSNK1D0.76974180
88MAP3K90.76432484
89PRKCB0.74674246
90UHMK10.74425377
91PDGFRA0.74096766
92PRKCZ0.73607461
93PAK30.72474608
94RPS6KB10.70694773
95MAPK120.70063972
96MINK10.69687536
97GSK3B0.68086927
98MAPK140.66127158
99SGK10.64805913
100MAPK100.64731225
101NTRK20.64429858
102RPS6KA30.64016027
103PTK20.62433250
104MAPKAPK50.61298283
105MAPK90.59736219
106MTOR0.59529501
107KSR10.58434935
108RIPK10.56056067
109DAPK20.55661490
110PRKDC0.55482831
111NTRK10.55448436
112MAP3K10.55338563
113PRKACG0.54898818
114MAPK110.53880868
115CSNK1A1L0.53440569
116CDK190.53264346
117MAP3K70.51064473
118PRKAA20.50729286
119ALK0.50389075
120RPS6KA20.48900773
121EPHA30.48498506
122MAP2K20.47940427
123PRKD10.47274168
124LATS20.47122189
125MAP2K70.44602958
126CDK10.43507772
127CAMK40.42268988
128PRKCG0.41181404
129MAP2K60.40974186
130MAPK80.40136217
131SRC0.40050801
132CAMK10.39862973
133NEK60.39407184
134STK110.38745673
135MAP2K40.37663016
136PRKACA0.37334310
137TAOK10.37017319
138CAMK2A0.36874640
139FYN0.36126697
140CSNK1A10.35359761
141FER0.35343440
142CSNK1G20.34416168
143PLK30.34158484
144NEK20.34146968
145RPS6KC10.33383632
146RPS6KL10.33383632
147CSNK1E0.32871481
148PDPK10.29067311

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.26341226
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.85622631
3Vitamin digestion and absorption_Homo sapiens_hsa049772.68751443
4Fat digestion and absorption_Homo sapiens_hsa049752.64519353
5Synaptic vesicle cycle_Homo sapiens_hsa047212.43959919
6Histidine metabolism_Homo sapiens_hsa003402.40914980
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.36684537
8Linoleic acid metabolism_Homo sapiens_hsa005912.19874210
9Renin-angiotensin system_Homo sapiens_hsa046142.11503694
10Olfactory transduction_Homo sapiens_hsa047402.02980153
11Phototransduction_Homo sapiens_hsa0474413.3510010
12GABAergic synapse_Homo sapiens_hsa047271.88439532
13Insulin secretion_Homo sapiens_hsa049111.70115114
14Protein digestion and absorption_Homo sapiens_hsa049741.62805744
15Arginine biosynthesis_Homo sapiens_hsa002201.55618104
16Circadian entrainment_Homo sapiens_hsa047131.46116390
17PPAR signaling pathway_Homo sapiens_hsa033201.40216201
18Arachidonic acid metabolism_Homo sapiens_hsa005901.40132953
19Ether lipid metabolism_Homo sapiens_hsa005651.38993092
20Cholinergic synapse_Homo sapiens_hsa047251.38736791
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35294005
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33483813
23Morphine addiction_Homo sapiens_hsa050321.31651354
24Circadian rhythm_Homo sapiens_hsa047101.25111359
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22287574
26Dopaminergic synapse_Homo sapiens_hsa047281.21683689
27Arginine and proline metabolism_Homo sapiens_hsa003301.19597026
28Glutamatergic synapse_Homo sapiens_hsa047241.17420964
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16102448
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07495302
31Type II diabetes mellitus_Homo sapiens_hsa049301.07397062
32Starch and sucrose metabolism_Homo sapiens_hsa005001.07141193
33Serotonergic synapse_Homo sapiens_hsa047261.06760730
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01409954
35Sphingolipid metabolism_Homo sapiens_hsa006001.01140583
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94278424
37Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92067586
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91636628
39Nicotine addiction_Homo sapiens_hsa050330.91213229
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90325498
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89294149
42Fatty acid biosynthesis_Homo sapiens_hsa000610.88823244
43Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88267729
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87818668
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85939892
46Notch signaling pathway_Homo sapiens_hsa043300.85800829
47ABC transporters_Homo sapiens_hsa020100.84232924
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81335475
49VEGF signaling pathway_Homo sapiens_hsa043700.78873420
50mTOR signaling pathway_Homo sapiens_hsa041500.78241549
51Sulfur metabolism_Homo sapiens_hsa009200.78130764
52Cocaine addiction_Homo sapiens_hsa050300.76954188
53Fatty acid degradation_Homo sapiens_hsa000710.75142251
54Amphetamine addiction_Homo sapiens_hsa050310.72584052
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72439934
56Renin secretion_Homo sapiens_hsa049240.71025677
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70840076
58Oxytocin signaling pathway_Homo sapiens_hsa049210.70451283
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70212664
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70157875
61Caffeine metabolism_Homo sapiens_hsa002320.68926028
62cAMP signaling pathway_Homo sapiens_hsa040240.66394960
63Long-term potentiation_Homo sapiens_hsa047200.66128963
64Salivary secretion_Homo sapiens_hsa049700.65176562
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64535183
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62267750
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62067864
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61049217
69Vibrio cholerae infection_Homo sapiens_hsa051100.59547316
70Fructose and mannose metabolism_Homo sapiens_hsa000510.57660040
71Phenylalanine metabolism_Homo sapiens_hsa003600.57057022
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57021845
73Glucagon signaling pathway_Homo sapiens_hsa049220.56128305
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.55990604
75Dilated cardiomyopathy_Homo sapiens_hsa054140.55457270
76Chemical carcinogenesis_Homo sapiens_hsa052040.55118626
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54819780
78Gastric acid secretion_Homo sapiens_hsa049710.54089628
79Fatty acid elongation_Homo sapiens_hsa000620.53424625
80Adherens junction_Homo sapiens_hsa045200.52305304
81Inositol phosphate metabolism_Homo sapiens_hsa005620.51939495
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51336429
83Taste transduction_Homo sapiens_hsa047420.50255066
84Ovarian steroidogenesis_Homo sapiens_hsa049130.49407173
85Fatty acid metabolism_Homo sapiens_hsa012120.49223593
86Retinol metabolism_Homo sapiens_hsa008300.48839293
87Folate biosynthesis_Homo sapiens_hsa007900.47956580
88Dorso-ventral axis formation_Homo sapiens_hsa043200.47480361
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47311915
90Thyroid hormone synthesis_Homo sapiens_hsa049180.46725718
91Lysine degradation_Homo sapiens_hsa003100.45985105
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44984591
93Cardiac muscle contraction_Homo sapiens_hsa042600.44806721
94Pancreatic secretion_Homo sapiens_hsa049720.44556847
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43604339
96Galactose metabolism_Homo sapiens_hsa000520.42999706
97Alcoholism_Homo sapiens_hsa050340.42866992
98GnRH signaling pathway_Homo sapiens_hsa049120.42268419
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40986534
100Nitrogen metabolism_Homo sapiens_hsa009100.39425397
101Endometrial cancer_Homo sapiens_hsa052130.39281427
102N-Glycan biosynthesis_Homo sapiens_hsa005100.38193220
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37421328
104Insulin resistance_Homo sapiens_hsa049310.37156711
105Renal cell carcinoma_Homo sapiens_hsa052110.36684767
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36041916
107Collecting duct acid secretion_Homo sapiens_hsa049660.35684179
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.35257568
109AMPK signaling pathway_Homo sapiens_hsa041520.35189090
110Glioma_Homo sapiens_hsa052140.32881851
111Calcium signaling pathway_Homo sapiens_hsa040200.32590923
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32465910
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31751476
114MAPK signaling pathway_Homo sapiens_hsa040100.30127860
115Bile secretion_Homo sapiens_hsa049760.26735178
116Gap junction_Homo sapiens_hsa045400.26026863
117Mineral absorption_Homo sapiens_hsa049780.25786890
118Estrogen signaling pathway_Homo sapiens_hsa049150.25497719
119Chemokine signaling pathway_Homo sapiens_hsa040620.25370720
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.25259094
121Lysosome_Homo sapiens_hsa041420.25116927
122Ras signaling pathway_Homo sapiens_hsa040140.25111856
123Insulin signaling pathway_Homo sapiens_hsa049100.24711802
124HIF-1 signaling pathway_Homo sapiens_hsa040660.24683001
125mRNA surveillance pathway_Homo sapiens_hsa030150.23024013
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22345173
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21750721
128ErbB signaling pathway_Homo sapiens_hsa040120.21277989
129Type I diabetes mellitus_Homo sapiens_hsa049400.21194918
130Melanogenesis_Homo sapiens_hsa049160.21124030
131Choline metabolism in cancer_Homo sapiens_hsa052310.20251725
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19488723
133Axon guidance_Homo sapiens_hsa043600.18784232
134Tight junction_Homo sapiens_hsa045300.18276092
135Wnt signaling pathway_Homo sapiens_hsa043100.17068854
136Prolactin signaling pathway_Homo sapiens_hsa049170.16936221
137Glycerolipid metabolism_Homo sapiens_hsa005610.16449232
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.16298150
139Protein export_Homo sapiens_hsa030600.15509024
140Long-term depression_Homo sapiens_hsa047300.15358839
141Non-small cell lung cancer_Homo sapiens_hsa052230.14576612

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