CDH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1wound healing, spreading of epidermal cells (GO:0035313)6.82801971
2lymph vessel development (GO:0001945)6.50416393
3vascular endothelial growth factor signaling pathway (GO:0038084)6.45553346
4positive regulation of vasculogenesis (GO:2001214)5.98954962
5retina vasculature morphogenesis in camera-type eye (GO:0061299)5.54138667
6endothelium development (GO:0003158)5.43770650
7cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.27071008
8regulation of vasculogenesis (GO:2001212)5.22295833
9surfactant homeostasis (GO:0043129)5.21477952
10lymphangiogenesis (GO:0001946)5.19856847
11regulation of endothelial cell differentiation (GO:0045601)4.98874470
12basement membrane organization (GO:0071711)4.91567901
13morphogenesis of an endothelium (GO:0003159)4.87465112
14endothelial tube morphogenesis (GO:0061154)4.87465112
15artery development (GO:0060840)4.80545903
16bundle of His cell to Purkinje myocyte communication (GO:0086069)4.71504825
17glomerular filtration (GO:0003094)4.69363412
18renal filtration (GO:0097205)4.57326675
19ovulation from ovarian follicle (GO:0001542)4.53200364
20heart trabecula formation (GO:0060347)4.52609385
21wound healing, spreading of cells (GO:0044319)4.49736275
22endothelial cell morphogenesis (GO:0001886)4.48688245
23regulation of blood vessel endothelial cell migration (GO:0043535)4.40905687
24patterning of blood vessels (GO:0001569)4.39655625
25Notch signaling involved in heart development (GO:0061314)4.37746390
26negative regulation of focal adhesion assembly (GO:0051895)4.30607868
27negative regulation of cell junction assembly (GO:1901889)4.30607868
28negative regulation of adherens junction organization (GO:1903392)4.30607868
29chemical homeostasis within a tissue (GO:0048875)4.20869583
30positive regulation of urine volume (GO:0035810)4.13466673
31cell migration involved in sprouting angiogenesis (GO:0002042)4.08066910
32vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.01057669
33blood vessel endothelial cell migration (GO:0043534)3.97348864
34plasma membrane repair (GO:0001778)3.97021392
35cardiac myofibril assembly (GO:0055003)3.93149089
36endothelial cell differentiation (GO:0045446)3.84875808
37venous blood vessel morphogenesis (GO:0048845)3.81773151
38vasculogenesis (GO:0001570)3.73206781
39positive regulation of endothelial cell migration (GO:0010595)3.69802642
40cell adhesion mediated by integrin (GO:0033627)3.69780245
41angiogenesis (GO:0001525)3.69170403
42negative regulation of vascular permeability (GO:0043116)3.65640283
43neuron remodeling (GO:0016322)3.61296730
44sarcomere organization (GO:0045214)3.59189924
45embryonic heart tube development (GO:0035050)3.58975126
46positive regulation of receptor recycling (GO:0001921)3.53184399
47hyaluronan catabolic process (GO:0030214)3.41791203
48negative regulation of DNA biosynthetic process (GO:2000279)3.40879726
49angiogenesis involved in wound healing (GO:0060055)3.35833036
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.35659671
51axon extension involved in axon guidance (GO:0048846)3.35659671
52sprouting angiogenesis (GO:0002040)3.34822926
53negative regulation of blood vessel morphogenesis (GO:2000181)3.31917288
54dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31577462
55negative regulation of blood vessel endothelial cell migration (GO:0043537)3.30475665
56cAMP biosynthetic process (GO:0006171)3.29952609
57positive regulation of endothelial cell differentiation (GO:0045603)3.29701445
58positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.29355237
59positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.28225902
60myofibril assembly (GO:0030239)3.26985082
61transcytosis (GO:0045056)3.26293379
62regulation of cardioblast differentiation (GO:0051890)3.25972763
63gap junction assembly (GO:0016264)3.24586840
64low-density lipoprotein particle clearance (GO:0034383)3.24550201
65positive regulation of odontogenesis (GO:0042482)3.24123917
66regulation of vascular permeability (GO:0043114)3.20486342
67negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.20148822
68fatty acid transmembrane transport (GO:1902001)3.19469897
69nephron epithelium development (GO:0072009)3.18622314
70positive regulation of endothelial cell proliferation (GO:0001938)3.18391608
71coronary vasculature morphogenesis (GO:0060977)3.15060944
72negative regulation of vasculature development (GO:1901343)3.14484185
73regulation of focal adhesion assembly (GO:0051893)3.12966862
74regulation of cell-substrate junction assembly (GO:0090109)3.12966862
75regulation of glomerular filtration (GO:0003093)3.11543862
76negative regulation of endothelial cell migration (GO:0010596)3.11144967
77negative regulation of Rho protein signal transduction (GO:0035024)3.10153957
78regulation of adherens junction organization (GO:1903391)3.09753123
79regulation of epithelial cell migration (GO:0010632)3.08793887
80regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.07739664
81positive regulation of epithelial cell migration (GO:0010634)3.06760783
82positive regulation of blood vessel endothelial cell migration (GO:0043536)3.05855637
83positive regulation of focal adhesion assembly (GO:0051894)3.05816935
84positive regulation of cell junction assembly (GO:1901890)3.05816935
85endothelial cell migration (GO:0043542)3.05779095
86ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.04919075
87negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.03852925
88regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.02737835
89establishment of endothelial barrier (GO:0061028)3.01407123
90positive regulation of adherens junction organization (GO:1903393)2.99934914
91negative regulation of anoikis (GO:2000811)2.97953266
92regulation of urine volume (GO:0035809)2.96398482
93plasma membrane fusion (GO:0045026)2.95990674
94ganglion development (GO:0061548)2.95772964
95regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.95075448
96endocrine process (GO:0050886)2.95075448
97regulation of systemic arterial blood pressure by hormone (GO:0001990)2.95075448
98blood vessel remodeling (GO:0001974)2.93796425
99trabecula formation (GO:0060343)2.92311340
100regulation of endothelial cell proliferation (GO:0001936)2.89402914
101regulation of tight junction assembly (GO:2000810)2.88607578
102negative regulation of endothelial cell apoptotic process (GO:2000352)2.88465208
103regulation of p38MAPK cascade (GO:1900744)2.88121625
104endodermal cell differentiation (GO:0035987)2.87442138
105regulation of the force of heart contraction (GO:0002026)2.86953543
106negative regulation of nitric-oxide synthase activity (GO:0051001)2.85633923
107regulation of endothelial cell apoptotic process (GO:2000351)2.84842851
108* blood vessel maturation (GO:0001955)2.84680895
109positive regulation of interleukin-8 secretion (GO:2000484)2.84595933
110semaphorin-plexin signaling pathway (GO:0071526)2.83496308
111protein localization to endosome (GO:0036010)2.83495686
112substrate-dependent cell migration (GO:0006929)2.83415208
113cyclic purine nucleotide metabolic process (GO:0052652)2.81673525
114cardiac muscle tissue morphogenesis (GO:0055008)2.79321095
115negative regulation of platelet activation (GO:0010544)2.79265929
116substrate adhesion-dependent cell spreading (GO:0034446)2.78481057
117positive regulation of endothelial cell apoptotic process (GO:2000353)2.78256748
118endothelial cell proliferation (GO:0001935)2.78047702
119trabecula morphogenesis (GO:0061383)2.76251597
120regulation of actin filament-based movement (GO:1903115)2.75298741
121ventricular trabecula myocardium morphogenesis (GO:0003222)2.75106218
122regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.72515812
123carnitine shuttle (GO:0006853)2.71611106
124peptidyl-tyrosine autophosphorylation (GO:0038083)2.71080541
125protein kinase C signaling (GO:0070528)2.70813622
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69177814
127endothelial cell chemotaxis (GO:0035767)2.69174331
128actomyosin structure organization (GO:0031032)2.68739659
129negative regulation of potassium ion transmembrane transport (GO:1901380)2.68557647
130ventricular cardiac muscle cell action potential (GO:0086005)2.66123512
131cyclic nucleotide biosynthetic process (GO:0009190)2.65993342
132glomerular basement membrane development (GO:0032836)2.65197794
133cell-substrate junction assembly (GO:0007044)2.64850265
134ovulation (GO:0030728)2.63952272
135regulation of endothelial cell migration (GO:0010594)2.60811840
136muscle filament sliding (GO:0030049)2.60683877
137actin-myosin filament sliding (GO:0033275)2.60683877
138heart trabecula morphogenesis (GO:0061384)2.60379645
139negative regulation of endothelial cell proliferation (GO:0001937)2.59988133
140regulation of sarcomere organization (GO:0060297)2.59827517
141cell migration involved in heart development (GO:0060973)2.58712896
142cGMP biosynthetic process (GO:0006182)2.57746204
143negative regulation of epithelial cell migration (GO:0010633)2.56436664
144adherens junction assembly (GO:0034333)2.56272776
145negative regulation of angiogenesis (GO:0016525)2.55196519
146cardiac muscle cell proliferation (GO:0060038)2.54669598
147cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54641975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.98364387
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.65167122
3CLOCK_20551151_ChIP-Seq_293T_Human3.48926750
4* GATA2_21666600_ChIP-Seq_HMVEC_Human3.10576788
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.86883850
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.85263347
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.69562684
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66786600
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60124018
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.46272045
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.30222731
12TBX20_22328084_ChIP-Seq_HEART_Mouse2.30222731
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.13196870
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.12216113
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12044265
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07280131
17GATA1_22025678_ChIP-Seq_K562_Human2.04932744
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03221776
19* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.03182477
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.02334121
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.01523479
22ZNF263_19887448_ChIP-Seq_K562_Human1.93914018
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93474289
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88558165
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.87476018
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84966922
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.84507050
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83565415
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83355038
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.75258919
31* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73965505
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73912070
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73208454
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.66286402
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61881061
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61094364
37GATA1_19941826_ChIP-Seq_K562_Human1.53693193
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.51512959
39CJUN_26792858_Chip-Seq_BT549_Human1.50852124
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.49792714
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46270357
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42455620
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41040063
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36696138
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35852130
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35833233
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32909399
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29903790
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28968126
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26627588
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25918442
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25454062
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.25446499
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23863721
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23504747
56KDM2B_26808549_Chip-Seq_K562_Human1.23341705
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21894060
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20746119
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.19591595
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18947367
61AHR_22903824_ChIP-Seq_MCF-7_Human1.18229810
62RACK7_27058665_Chip-Seq_MCF-7_Human1.17779192
63SOX2_20726797_ChIP-Seq_SW620_Human1.16579124
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15479737
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15479737
66MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14646596
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14541909
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14056888
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13682855
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.12678079
71KDM2B_26808549_Chip-Seq_DND41_Human1.12653992
72* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11973379
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.11842284
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.06930078
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06108553
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06108553
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03853154
78TP53_23651856_ChIP-Seq_MEFs_Mouse1.03707523
79FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03114596
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02856537
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02824190
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02315061
83BRD4_25478319_ChIP-Seq_HGPS_Human1.02013809
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01716563
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00635475
86WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99174594
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98783824
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98346543
89LXR_22292898_ChIP-Seq_THP-1_Human0.98336872
90* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98094862
91* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98053503
92P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97962317
93SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96287883
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96190453
95* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94928670
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94562091
97GATA2_19941826_ChIP-Seq_K562_Human0.92739362
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.92715373
99RNF2_27304074_Chip-Seq_ESCs_Mouse0.91513906
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90712580
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90317918
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90289241
103EED_16625203_ChIP-ChIP_MESCs_Mouse0.89920266
104* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88668708
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88350915
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88152736
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87623563
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87155075
109* UBF1/2_26484160_Chip-Seq_HMECs_Human0.86648568
110JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85987646
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85892634
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85892634
113* RUNX1_27514584_Chip-Seq_MCF-7_Human0.85695367
114RUNX_20019798_ChIP-Seq_JUKART_Human0.85184202
115ARNT_22903824_ChIP-Seq_MCF-7_Human0.85153572
116EZH2_27294783_Chip-Seq_ESCs_Mouse0.84871590
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84311908
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81320572
119RXR_22108803_ChIP-Seq_LS180_Human0.80636349
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79282103
121SCL_19346495_ChIP-Seq_HPC-7_Human0.79204420
122TCF7_22412390_ChIP-Seq_EML_Mouse0.77973857
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77836903
124DROSHA_22980978_ChIP-Seq_HELA_Human0.77801148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.85484651
2MP0004272_abnormal_basement_membrane5.06413628
3MP0001879_abnormal_lymphatic_vessel4.90177178
4MP0004084_abnormal_cardiac_muscle4.02819115
5MP0005167_abnormal_blood-brain_barrier3.98871548
6MP0003828_pulmonary_edema2.82683369
7MP0003705_abnormal_hypodermis_morpholog2.75344433
8MP0004036_abnormal_muscle_relaxation2.63493907
9MP0004215_abnormal_myocardial_fiber2.55226231
10MP0002837_dystrophic_cardiac_calcinosis2.53051940
11MP0000751_myopathy2.42605901
12MP0006054_spinal_hemorrhage2.38230608
13MP0006138_congestive_heart_failure2.31134862
14MP0008775_abnormal_heart_ventricle2.23325686
15MP0003279_aneurysm2.18785734
16MP0005330_cardiomyopathy2.05267909
17MP0003566_abnormal_cell_adhesion2.00209428
18MP0001544_abnormal_cardiovascular_syste1.99866103
19MP0005385_cardiovascular_system_phenoty1.99866103
20MP0003724_increased_susceptibility_to1.98398170
21MP0005409_darkened_coat_color1.93595613
22MP0000767_abnormal_smooth_muscle1.92335504
23MP0008438_abnormal_cutaneous_collagen1.91629299
24MP0002877_abnormal_melanocyte_morpholog1.88524151
25MP0002972_abnormal_cardiac_muscle1.81675584
26MP0000013_abnormal_adipose_tissue1.79373979
27MP0010630_abnormal_cardiac_muscle1.79139088
28MP0010030_abnormal_orbit_morphology1.79034829
29MP0005623_abnormal_meninges_morphology1.76383805
30MP0001958_emphysema1.68751352
31MP0004130_abnormal_muscle_cell1.62602191
32MP0004484_altered_response_of1.60403600
33MP0000343_altered_response_to1.58499565
34MP0004087_abnormal_muscle_fiber1.56850125
35MP0003567_abnormal_fetal_cardiomyocyte1.55106455
36MP0002127_abnormal_cardiovascular_syste1.52211691
37MP0005165_increased_susceptibility_to1.51645459
38MP0005620_abnormal_muscle_contractility1.50941110
39MP0000750_abnormal_muscle_regeneration1.50207616
40MP0003950_abnormal_plasma_membrane1.49202510
41MP0002128_abnormal_blood_circulation1.45937521
42MP0004510_myositis1.45324654
43MP0000749_muscle_degeneration1.44613166
44MP0005670_abnormal_white_adipose1.44046859
45MP0000249_abnormal_blood_vessel1.42046865
46MP0002933_joint_inflammation1.41049956
47MP0002332_abnormal_exercise_endurance1.39184682
48* MP0004085_abnormal_heartbeat1.33121363
49MP0002138_abnormal_hepatobiliary_system1.32236743
50MP0002295_abnormal_pulmonary_circulatio1.31860288
51* MP0002925_abnormal_cardiovascular_devel1.29210612
52MP0003191_abnormal_cellular_cholesterol1.25833143
53MP0005595_abnormal_vascular_smooth1.25752023
54MP0004233_abnormal_muscle_weight1.23143695
55* MP0001614_abnormal_blood_vessel1.17819212
56MP0002106_abnormal_muscle_physiology1.17314497
57MP0005275_abnormal_skin_tensile1.13287392
58* MP0000266_abnormal_heart_morphology1.12701410
59MP0003091_abnormal_cell_migration1.12121386
60MP0004145_abnormal_muscle_electrophysio1.08672916
61MP0003300_gastrointestinal_ulcer1.06655211
62MP0000003_abnormal_adipose_tissue1.05993589
63MP0004883_abnormal_blood_vessel1.03868912
64MP0003868_abnormal_feces_composition1.02213767
65MP0005666_abnormal_adipose_tissue1.00870567
66MP0003221_abnormal_cardiomyocyte_apopto0.99910970
67MP0004147_increased_porphyrin_level0.99722530
68MP0009278_abnormal_bone_marrow0.99129123
69MP0005375_adipose_tissue_phenotype0.97514806
70MP0003122_maternal_imprinting0.96524656
71MP0004185_abnormal_adipocyte_glucose0.96143787
72MP0003646_muscle_fatigue0.95982919
73MP0005187_abnormal_penis_morphology0.95949313
74MP0005164_abnormal_response_to0.94729318
75MP0000230_abnormal_systemic_arterial0.94602415
76MP0005369_muscle_phenotype0.93125567
77MP0004782_abnormal_surfactant_physiolog0.92633216
78MP0001849_ear_inflammation0.92510291
79MP0001915_intracranial_hemorrhage0.91973357
80MP0005360_urolithiasis0.88540722
81MP0003137_abnormal_impulse_conducting0.87009020
82MP0010352_gastrointestinal_tract_polyps0.86014933
83MP0003303_peritoneal_inflammation0.83554747
84MP0001784_abnormal_fluid_regulation0.83408598
85MP0003045_fibrosis0.82863242
86MP0003941_abnormal_skin_development0.80331303
87MP0000759_abnormal_skeletal_muscle0.78958196
88MP0005388_respiratory_system_phenotype0.76388764
89MP0002133_abnormal_respiratory_system0.76388764
90* MP0002086_abnormal_extraembryonic_tissu0.73680775
91MP0010329_abnormal_lipoprotein_level0.70608124
92MP0000465_gastrointestinal_hemorrhage0.70384262
93MP0005084_abnormal_gallbladder_morpholo0.70221234
94MP0005023_abnormal_wound_healing0.69587737
95MP0002269_muscular_atrophy0.68932985
96MP0000733_abnormal_muscle_development0.67517018
97MP0009697_abnormal_copulation0.66171617
98MP0001851_eye_inflammation0.63516677
99MP0000049_abnormal_middle_ear0.62640429
100MP0000537_abnormal_urethra_morphology0.62260062
101* MP0003984_embryonic_growth_retardation0.62145444
102MP0009780_abnormal_chondrocyte_physiolo0.61595147
103* MP0002088_abnormal_embryonic_growth/wei0.61357527
104MP0002932_abnormal_joint_morphology0.60573829
105MP0001756_abnormal_urination0.60382636
106MP0008004_abnormal_stomach_pH0.59567005
107MP0003948_abnormal_gas_homeostasis0.57501804
108MP0003252_abnormal_bile_duct0.55763573
109MP0002108_abnormal_muscle_morphology0.55578400
110MP0002168_other_aberrant_phenotype0.54840917
111MP0002796_impaired_skin_barrier0.54499612
112* MP0003935_abnormal_craniofacial_develop0.54038082
113MP0004264_abnormal_extraembryonic_tissu0.53294406
114MP0000467_abnormal_esophagus_morphology0.52578107
115MP0003385_abnormal_body_wall0.50950192
116MP0002092_abnormal_eye_morphology0.50431833
117MP0002896_abnormal_bone_mineralization0.50129531
118MP0001175_abnormal_lung_morphology0.50061006
119MP0010234_abnormal_vibrissa_follicle0.50002242
120MP0000747_muscle_weakness0.48410385
121MP0005197_abnormal_uvea_morphology0.45086316

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)5.52952995
2Muscle fiber splitting (HP:0003555)4.82320786
3Sudden death (HP:0001699)4.68818846
4Cerebral aneurysm (HP:0004944)4.58319180
5Ventricular tachycardia (HP:0004756)4.54051876
6Hematochezia (HP:0002573)4.47440864
7Increased connective tissue (HP:0009025)4.36804338
8Right ventricular cardiomyopathy (HP:0011663)4.35606392
9Spontaneous hematomas (HP:0007420)4.34795150
10Hyporeflexia of lower limbs (HP:0002600)4.26254021
11Esophageal varix (HP:0002040)4.08604463
12Lymphangioma (HP:0100764)3.92368380
13Atrial fibrillation (HP:0005110)3.82917639
14Supraventricular arrhythmia (HP:0005115)3.72056590
15Broad metatarsal (HP:0001783)3.67673783
16Primary atrial arrhythmia (HP:0001692)3.54579313
17Difficulty running (HP:0009046)3.38977013
18Lipoatrophy (HP:0100578)3.36757749
19Supraventricular tachycardia (HP:0004755)3.36305022
20Deep venous thrombosis (HP:0002625)3.11639380
21Cerebral hemorrhage (HP:0001342)3.10932410
22Exercise-induced muscle cramps (HP:0003710)3.07013029
23Nonimmune hydrops fetalis (HP:0001790)3.03348319
24Protrusio acetabuli (HP:0003179)3.03347632
25Atrioventricular block (HP:0001678)3.01037252
26Aneurysm (HP:0002617)2.99619122
27Visceral angiomatosis (HP:0100761)2.99608567
28Increased variability in muscle fiber diameter (HP:0003557)2.89639778
29Syncope (HP:0001279)2.89272660
30Menorrhagia (HP:0000132)2.85888003
31Hemangiomatosis (HP:0007461)2.82389602
32Capillary hemangiomas (HP:0005306)2.81388145
33Conjunctival telangiectasia (HP:0000524)2.79907033
34Aortic aneurysm (HP:0004942)2.79576899
35Hemorrhage of the eye (HP:0011885)2.77598856
36Abnormality of the nasal mucosa (HP:0000433)2.77556933
37Hip contracture (HP:0003273)2.75204581
38Asymmetry of the thorax (HP:0001555)2.75071800
39Pulmonary artery stenosis (HP:0004415)2.71185981
40Abnormality of the left ventricular outflow tract (HP:0011103)2.69948884
41Subaortic stenosis (HP:0001682)2.69948884
42EMG: myopathic abnormalities (HP:0003458)2.69155357
43Abnormality of skeletal muscle fiber size (HP:0012084)2.67936846
44Exercise-induced myalgia (HP:0003738)2.66457633
45Difficulty climbing stairs (HP:0003551)2.64737242
46Myotonia (HP:0002486)2.62234998
47Neonatal death (HP:0003811)2.61043293
48Vertebral clefting (HP:0008428)2.60360042
49Calf muscle hypertrophy (HP:0008981)2.60242962
50Dilated cardiomyopathy (HP:0001644)2.59075527
51Asymmetric septal hypertrophy (HP:0001670)2.57843166
52Cervical subluxation (HP:0003308)2.56616219
53Cavernous hemangioma (HP:0001048)2.54540403
54Porencephaly (HP:0002132)2.54052663
55Prolonged QT interval (HP:0001657)2.53584922
56Heart block (HP:0012722)2.53326544
57Mesangial abnormality (HP:0001966)2.49834230
58Abnormal vertebral ossification (HP:0100569)2.49615768
59Palpitations (HP:0001962)2.48888575
60Spinal rigidity (HP:0003306)2.48844124
61Skull defect (HP:0001362)2.48458614
62Abnormality of the calf musculature (HP:0001430)2.47624056
63Myoglobinuria (HP:0002913)2.46128233
64Joint hemorrhage (HP:0005261)2.45865571
65Hemiplegia (HP:0002301)2.44158901
66Abnormal atrioventricular conduction (HP:0005150)2.42894550
67Adactyly (HP:0009776)2.36570658
68Aortic dissection (HP:0002647)2.35583190
69Aortic valve stenosis (HP:0001650)2.34999005
70Hypoglycemic coma (HP:0001325)2.33479271
71Flexion contracture of toe (HP:0005830)2.33235135
72Joint contractures involving the joints of the feet (HP:0100492)2.33235135
73High pitched voice (HP:0001620)2.30831716
74Abnormality of the vasculature of the conjunctiva (HP:0008054)2.30760322
75Limited hip movement (HP:0008800)2.30253730
76Abnormality of the intrinsic pathway (HP:0010989)2.27738428
77Rectal prolapse (HP:0002035)2.27429680
78Muscle hypertrophy of the lower extremities (HP:0008968)2.27085567
79Premature rupture of membranes (HP:0001788)2.25837574
80Abnormal platelet function (HP:0011869)2.24971933
81Impaired platelet aggregation (HP:0003540)2.24971933
82Centrally nucleated skeletal muscle fibers (HP:0003687)2.24049386
83Mitral valve prolapse (HP:0001634)2.23031854
84Portal hypertension (HP:0001409)2.20834646
85Hypoplasia of the iris (HP:0007676)2.20601611
86Ectopia lentis (HP:0001083)2.17575014
87Ventricular arrhythmia (HP:0004308)2.17557303
88Bundle branch block (HP:0011710)2.14652381
89Shallow orbits (HP:0000586)2.14261246
90Mucosal telangiectasiae (HP:0100579)2.09569713
91Facial diplegia (HP:0001349)2.08522068
92Trismus (HP:0000211)2.07006477
93Wormian bones (HP:0002645)2.06998810
94Type 1 muscle fiber predominance (HP:0003803)2.05802267
95Venous abnormality (HP:0002624)2.04011566
96Tetraparesis (HP:0002273)2.03749218
97Ankyloglossia (HP:0010296)2.02979290
98Stroke (HP:0001297)2.02456750
99Stenosis of the external auditory canal (HP:0000402)2.02394592
100Ventricular fibrillation (HP:0001663)1.99857932
101Ankle contracture (HP:0006466)1.97891272
102Venous insufficiency (HP:0005293)1.97112650
103Absent hand (HP:0004050)1.94714051
104Malignant hyperthermia (HP:0002047)1.94562097
105Wrist flexion contracture (HP:0001239)1.94000579
106Coxa vara (HP:0002812)1.93862211
107Myocardial infarction (HP:0001658)1.93616104
108Distal lower limb amyotrophy (HP:0008944)1.92791838
109Abnormality of the hepatic vasculature (HP:0006707)1.92100424
110Rhabdomyolysis (HP:0003201)1.89753897
111Distal arthrogryposis (HP:0005684)1.89301063
112Bladder diverticulum (HP:0000015)1.89288177
113Broad face (HP:0000283)1.89097598
114Vascular tortuosity (HP:0004948)1.88075836
115Overgrowth (HP:0001548)1.87587538
116Mask-like facies (HP:0000298)1.81717206
117Disproportionate tall stature (HP:0001519)1.81537991
118Lymphedema (HP:0001004)1.80916997
119Bulbous nose (HP:0000414)1.79620479
120Bicuspid aortic valve (HP:0001647)1.78807535
121Acanthosis nigricans (HP:0000956)1.78448673
122Pulmonary hypertension (HP:0002092)1.77657797
123Hydroureter (HP:0000072)1.76969452
124Distal lower limb muscle weakness (HP:0009053)1.76899767
125Muscle stiffness (HP:0003552)1.76525362
126Abnormality of the 4th metacarpal (HP:0010012)1.76397895
127Striae distensae (HP:0001065)1.76092521
128Mildly elevated creatine phosphokinase (HP:0008180)1.75324013
129Abnormality of oral frenula (HP:0000190)1.75012566
130Areflexia of lower limbs (HP:0002522)1.74581444
131Arterial tortuosity (HP:0005116)1.73361939
132Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.73090765
133Blue sclerae (HP:0000592)1.71442366
134Nemaline bodies (HP:0003798)1.70827609
135Muscle fiber inclusion bodies (HP:0100299)1.70816082
136Camptodactyly of toe (HP:0001836)1.70504109
137Epistaxis (HP:0000421)1.69081539
138Polygenic inheritance (HP:0010982)1.68832997
139Sudden cardiac death (HP:0001645)1.67521766
140Interstitial pulmonary disease (HP:0006530)1.66698352
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65264441
142Short 4th metacarpal (HP:0010044)1.65264441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.76031032
2TGFBR23.74497760
3RIPK12.69567070
4TRIB32.64556856
5TTN2.43931986
6FES2.35358813
7TGFBR12.31166746
8PKN22.26474716
9EPHB22.09520283
10TIE110.0932441
11PTK2B1.97565626
12MYLK1.95701755
13DMPK1.80790776
14ERN11.60377076
15PTK61.60080060
16FER1.49280356
17PDGFRA1.46118867
18PDK21.45547747
19EPHB11.43049656
20NTRK11.40339474
21LMTK21.33975900
22PRKG21.23351099
23MAP2K31.18953757
24PAK41.08680837
25LRRK21.06669681
26FGFR41.05923801
27PRKD11.05402400
28MAP3K30.98258859
29OBSCN0.98098620
30PHKG10.97420789
31PHKG20.97420789
32LATS10.90795744
33PTK20.89789997
34MAPK120.86485430
35GRK10.86281550
36PDK30.84352933
37PDK40.84352933
38EEF2K0.82544271
39STK100.81382578
40FGFR30.76338676
41CSK0.72116134
42INSRR0.70737151
43FGFR20.69875177
44PRKCH0.69086377
45PRKAA20.67896642
46ILK0.65643771
47PDPK10.65106457
48BCKDK0.60540024
49PDGFRB0.58892222
50SIK10.58855240
51ZAP700.58720499
52PRKD30.57532563
53MET0.57388751
54CAMK1D0.57362819
55MOS0.56837884
56MAP3K70.55427371
57MARK30.54829503
58ROCK10.54745032
59RET0.53701339
60MAP3K10.53173179
61LATS20.52796657
62RPS6KA20.51442483
63GSK3A0.50209278
64CAMK1G0.48571824
65PAK20.46942376
66PIK3CA0.46540670
67PAK30.45661048
68STK240.44529300
69NEK90.44011631
70MAPKAPK30.43937490
71WNK40.43336745
72EPHA20.42731491
73TRPM70.39448706
74IGF1R0.39251200
75MARK20.38696561
76MAP3K100.38400312
77MTOR0.37543342
78MAPK70.37179418
79HCK0.36900622
80EGFR0.35399333
81CDC42BPA0.35270331
82MAP2K10.35119813
83PDK10.34163007
84TESK10.33267748
85JAK30.32293513
86CAMK40.31404434
87* SRC0.31224897
88PRKAA10.31112333
89ERBB40.31048184
90JAK10.30510030
91ROCK20.29445038
92MAP3K110.27895900
93STK30.27864275
94EPHA30.27583461
95SGK30.27581112
96FGFR10.27281120
97MAP3K130.27211396
98NLK0.26779716
99GRK50.26421704
100SGK20.25271315
101MAP2K20.25073894
102PRKCE0.24517755
103BMX0.23989138
104TBK10.23896937
105IRAK30.23184239
106JAK20.23141086
107MAP4K10.23113105
108FLT30.22919473
109AKT20.22812056
110NEK10.22428380
111MAP3K60.21969716
112CDK90.21914660
113AKT30.21190472
114CDK60.20861488
115FRK0.20329138
116PIK3CG0.20136085
117TYRO30.20117042
118DAPK30.18149262
119TEC0.18004649
120SMG10.17419230
121SCYL20.17076668
122ITK0.16898917
123BCR0.16661945
124INSR0.16401434
125DDR20.16198265
126MAPKAPK50.15952445
127MAP3K120.15810272
128CDK80.15543998
129SGK2230.15077869
130SGK4940.15077869
131ICK0.14966279
132LCK0.13327264
133MAPK40.12776222
134BMPR1B0.12501376
135PAK60.11487277
136ARAF0.11091269
137LIMK10.11024656
138KSR20.09729227

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.64657858
2ECM-receptor interaction_Homo sapiens_hsa045122.96718915
3Dilated cardiomyopathy_Homo sapiens_hsa054142.79119264
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.71687037
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.59812009
6Focal adhesion_Homo sapiens_hsa045102.40158679
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.27153285
8Fatty acid degradation_Homo sapiens_hsa000712.15694644
9Adherens junction_Homo sapiens_hsa045202.07947590
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03700726
11PPAR signaling pathway_Homo sapiens_hsa033201.88284414
12Propanoate metabolism_Homo sapiens_hsa006401.87075611
13Arginine biosynthesis_Homo sapiens_hsa002201.73182566
14Dorso-ventral axis formation_Homo sapiens_hsa043201.72222011
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.66738875
16Complement and coagulation cascades_Homo sapiens_hsa046101.65931306
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64665273
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.64143258
19Fatty acid metabolism_Homo sapiens_hsa012121.60281788
20Nitrogen metabolism_Homo sapiens_hsa009101.55319080
21Viral myocarditis_Homo sapiens_hsa054161.53498247
22Small cell lung cancer_Homo sapiens_hsa052221.51043048
23* Leukocyte transendothelial migration_Homo sapiens_hsa046701.50282618
24Amoebiasis_Homo sapiens_hsa051461.49278052
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43130517
26Insulin resistance_Homo sapiens_hsa049311.34217143
27Bladder cancer_Homo sapiens_hsa052191.31895334
28Tight junction_Homo sapiens_hsa045301.31816838
29Proteoglycans in cancer_Homo sapiens_hsa052051.29327243
30Rap1 signaling pathway_Homo sapiens_hsa040151.26341006
31Platelet activation_Homo sapiens_hsa046111.24035528
32Caffeine metabolism_Homo sapiens_hsa002321.23603086
33Bile secretion_Homo sapiens_hsa049761.22561370
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20825873
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.19055179
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.16781710
37Protein digestion and absorption_Homo sapiens_hsa049741.12510632
38Notch signaling pathway_Homo sapiens_hsa043301.11532692
39Cardiac muscle contraction_Homo sapiens_hsa042601.09767154
40Pertussis_Homo sapiens_hsa051331.09510752
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07324231
42Tryptophan metabolism_Homo sapiens_hsa003801.06094213
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02110285
44Renin secretion_Homo sapiens_hsa049241.01497935
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01066750
46VEGF signaling pathway_Homo sapiens_hsa043701.01007196
47Renal cell carcinoma_Homo sapiens_hsa052111.00618328
48Pancreatic cancer_Homo sapiens_hsa052120.96158273
49GnRH signaling pathway_Homo sapiens_hsa049120.94520182
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94289373
51Toxoplasmosis_Homo sapiens_hsa051450.94024236
52Fat digestion and absorption_Homo sapiens_hsa049750.93860182
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93299228
54Shigellosis_Homo sapiens_hsa051310.90076072
55Malaria_Homo sapiens_hsa051440.88101384
56HIF-1 signaling pathway_Homo sapiens_hsa040660.88046668
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88021963
58Axon guidance_Homo sapiens_hsa043600.87562277
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87190218
60Carbon metabolism_Homo sapiens_hsa012000.86305414
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86238516
62Lysine degradation_Homo sapiens_hsa003100.85268989
63Ovarian steroidogenesis_Homo sapiens_hsa049130.84128157
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83711295
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80343657
66Pyruvate metabolism_Homo sapiens_hsa006200.72784606
67Basal cell carcinoma_Homo sapiens_hsa052170.71208580
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70781360
69Estrogen signaling pathway_Homo sapiens_hsa049150.69397628
70AMPK signaling pathway_Homo sapiens_hsa041520.68176950
71Pathways in cancer_Homo sapiens_hsa052000.68101149
72Glioma_Homo sapiens_hsa052140.65828372
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65630299
74TGF-beta signaling pathway_Homo sapiens_hsa043500.64949766
75Fatty acid biosynthesis_Homo sapiens_hsa000610.64239198
76Staphylococcus aureus infection_Homo sapiens_hsa051500.63645842
77Gap junction_Homo sapiens_hsa045400.63574015
78Ras signaling pathway_Homo sapiens_hsa040140.62061286
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61647514
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.60801493
81Glucagon signaling pathway_Homo sapiens_hsa049220.59936367
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58647881
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.58199393
84Choline metabolism in cancer_Homo sapiens_hsa052310.57744210
85MAPK signaling pathway_Homo sapiens_hsa040100.57514139
86Renin-angiotensin system_Homo sapiens_hsa046140.57313743
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56847622
88African trypanosomiasis_Homo sapiens_hsa051430.56484865
89Insulin signaling pathway_Homo sapiens_hsa049100.55113001
90Starch and sucrose metabolism_Homo sapiens_hsa005000.55105342
91* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54847007
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54424045
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54385716
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.53311385
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51525225
96cAMP signaling pathway_Homo sapiens_hsa040240.50930305
97Salmonella infection_Homo sapiens_hsa051320.49541570
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49186872
99Butanoate metabolism_Homo sapiens_hsa006500.48711580
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.48478758
101Oxytocin signaling pathway_Homo sapiens_hsa049210.48197635
102MicroRNAs in cancer_Homo sapiens_hsa052060.47931004
103beta-Alanine metabolism_Homo sapiens_hsa004100.47825399
104Hippo signaling pathway_Homo sapiens_hsa043900.47154599
105Glycerolipid metabolism_Homo sapiens_hsa005610.44482881
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44002484
107Gastric acid secretion_Homo sapiens_hsa049710.43902008
108Fatty acid elongation_Homo sapiens_hsa000620.42980993
109Endocytosis_Homo sapiens_hsa041440.42370701
110Hedgehog signaling pathway_Homo sapiens_hsa043400.41730201
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40876488
112Chronic myeloid leukemia_Homo sapiens_hsa052200.40795935
113Thyroid hormone synthesis_Homo sapiens_hsa049180.40276880
114Serotonergic synapse_Homo sapiens_hsa047260.39902445
115Osteoclast differentiation_Homo sapiens_hsa043800.39643050
116Other glycan degradation_Homo sapiens_hsa005110.39097932
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38916166
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37118687
119Glutamatergic synapse_Homo sapiens_hsa047240.36690161
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35865906
121Arginine and proline metabolism_Homo sapiens_hsa003300.35507064
122Melanogenesis_Homo sapiens_hsa049160.34640144
123FoxO signaling pathway_Homo sapiens_hsa040680.34610547
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.34467180
125Phagosome_Homo sapiens_hsa041450.34353502
126Pancreatic secretion_Homo sapiens_hsa049720.34218215
127TNF signaling pathway_Homo sapiens_hsa046680.34179316
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34148876
129Long-term depression_Homo sapiens_hsa047300.33601024
130ABC transporters_Homo sapiens_hsa020100.33110560
131Prion diseases_Homo sapiens_hsa050200.32751696
132Thyroid cancer_Homo sapiens_hsa052160.32702996
133Inositol phosphate metabolism_Homo sapiens_hsa005620.32657065
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32046499
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31664272
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31533864

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