CDH18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.63779654
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.54655962
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35834157
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.30361410
5glutamate secretion (GO:0014047)5.25647911
6vocalization behavior (GO:0071625)5.11341724
7locomotory exploration behavior (GO:0035641)5.05108702
8cerebellar Purkinje cell differentiation (GO:0021702)4.96873116
9synaptic vesicle maturation (GO:0016188)4.94766107
10regulation of synaptic vesicle exocytosis (GO:2000300)4.84959177
11neuron cell-cell adhesion (GO:0007158)4.79042490
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.76684526
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.73354300
14neuronal action potential propagation (GO:0019227)4.69253385
15behavioral response to nicotine (GO:0035095)4.63944324
16protein localization to synapse (GO:0035418)4.56764221
17neurotransmitter secretion (GO:0007269)4.55663734
18regulation of synaptic vesicle transport (GO:1902803)4.53900657
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.45808503
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.39781116
21proline transport (GO:0015824)4.36056793
22regulation of glutamate receptor signaling pathway (GO:1900449)4.32220515
23glutamate receptor signaling pathway (GO:0007215)4.31804842
24neuron-neuron synaptic transmission (GO:0007270)4.22731413
25synaptic transmission, glutamatergic (GO:0035249)4.18338220
26G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.17482309
27cerebellar granule cell differentiation (GO:0021707)4.13778693
28cellular potassium ion homeostasis (GO:0030007)4.13601951
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09173932
30gamma-aminobutyric acid transport (GO:0015812)4.08825823
31gamma-aminobutyric acid signaling pathway (GO:0007214)4.08575641
32neurotransmitter-gated ion channel clustering (GO:0072578)4.04280483
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00049656
34neuromuscular process controlling posture (GO:0050884)3.98723606
35exploration behavior (GO:0035640)3.93715295
36axonal fasciculation (GO:0007413)3.78187221
37neuron recognition (GO:0008038)3.77948195
38neurotransmitter transport (GO:0006836)3.76641621
39layer formation in cerebral cortex (GO:0021819)3.75070362
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73667917
41long-term memory (GO:0007616)3.72737168
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.72659428
43positive regulation of synapse maturation (GO:0090129)3.72272304
44C4-dicarboxylate transport (GO:0015740)3.71901484
45synaptic vesicle endocytosis (GO:0048488)3.70192872
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.66988360
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.65717685
48positive regulation of membrane potential (GO:0045838)3.60323798
49regulation of postsynaptic membrane potential (GO:0060078)3.59782376
50membrane hyperpolarization (GO:0060081)3.58099152
51response to pheromone (GO:0019236)3.56692300
52auditory behavior (GO:0031223)3.56136572
53cell differentiation in hindbrain (GO:0021533)3.54595321
54membrane depolarization during action potential (GO:0086010)3.52949827
55response to histamine (GO:0034776)3.52624033
56regulation of neuronal synaptic plasticity (GO:0048168)3.50870118
57positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.46547989
58sodium ion export (GO:0071436)3.46463802
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.46366721
60regulation of neurotransmitter levels (GO:0001505)3.44811929
61pyrimidine nucleobase catabolic process (GO:0006208)3.43122715
62postsynaptic membrane organization (GO:0001941)3.41553840
63innervation (GO:0060384)3.41242709
64presynaptic membrane organization (GO:0097090)3.38796999
65regulation of synapse structural plasticity (GO:0051823)3.38631791
66regulation of neurotransmitter secretion (GO:0046928)3.37088071
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.35667039
68presynaptic membrane assembly (GO:0097105)3.35259169
69short-term memory (GO:0007614)3.34209306
70retinal cone cell development (GO:0046549)3.33365554
71long-term synaptic potentiation (GO:0060291)3.31643248
72dendritic spine morphogenesis (GO:0060997)3.30424299
73membrane depolarization (GO:0051899)3.28426582
74neurofilament cytoskeleton organization (GO:0060052)3.26924193
75startle response (GO:0001964)3.26419357
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21171287
77activation of protein kinase A activity (GO:0034199)3.20431719
78positive regulation of synapse assembly (GO:0051965)3.18225861
79synapse assembly (GO:0007416)3.16340932
80neuronal action potential (GO:0019228)3.15686857
81protein polyglutamylation (GO:0018095)3.15587908
82transmission of nerve impulse (GO:0019226)3.15159448
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11977172
84positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10540374
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10215852
86regulation of neurotransmitter transport (GO:0051588)3.10173393
87nucleobase catabolic process (GO:0046113)3.10024289
88dendrite morphogenesis (GO:0048813)3.09889156
89regulation of synaptic plasticity (GO:0048167)3.08293504
90synaptic transmission (GO:0007268)3.05735169
91negative regulation of cytosolic calcium ion concentration (GO:0051481)3.05531415
92mechanosensory behavior (GO:0007638)3.04858655
93response to auditory stimulus (GO:0010996)3.03303118
94prepulse inhibition (GO:0060134)3.01360842
95regulation of voltage-gated calcium channel activity (GO:1901385)3.00854730
96neuromuscular process controlling balance (GO:0050885)3.00683132
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.97900819
98behavioral response to ethanol (GO:0048149)2.97058867
99regulation of action potential (GO:0098900)2.95829191
100righting reflex (GO:0060013)2.95314442
101positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95166130
102detection of light stimulus involved in visual perception (GO:0050908)2.94529864
103detection of light stimulus involved in sensory perception (GO:0050962)2.94529864
104regulation of respiratory system process (GO:0044065)2.93516824
105positive regulation of action potential (GO:0045760)2.93002288
106primary amino compound metabolic process (GO:1901160)2.92509590
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.92451378
108positive regulation of potassium ion transmembrane transport (GO:1901381)2.92162589
109serotonin metabolic process (GO:0042428)2.92064952
110neuromuscular process (GO:0050905)2.91891562
111synapse organization (GO:0050808)2.91316628
112glycosphingolipid biosynthetic process (GO:0006688)2.90879854
113behavioral response to cocaine (GO:0048148)2.90446414
114adult walking behavior (GO:0007628)2.89832821
115detection of calcium ion (GO:0005513)2.89090913
116calcium ion-dependent exocytosis (GO:0017156)2.86775683
117positive regulation of synaptic transmission (GO:0050806)2.85982407
118synaptic vesicle transport (GO:0048489)2.85788335
119establishment of synaptic vesicle localization (GO:0097480)2.85788335
120regulation of cell communication by electrical coupling (GO:0010649)2.84353110
121regulation of vesicle fusion (GO:0031338)2.84189726
122regulation of synapse maturation (GO:0090128)2.83142478
123positive regulation of neurotransmitter transport (GO:0051590)2.82112100
124regulation of synaptic transmission (GO:0050804)2.81568321
125fucose catabolic process (GO:0019317)2.78508772
126L-fucose metabolic process (GO:0042354)2.78508772
127L-fucose catabolic process (GO:0042355)2.78508772
128neuromuscular synaptic transmission (GO:0007274)2.78433981
129protein localization to cilium (GO:0061512)2.74861384
130regulation of neurotransmitter uptake (GO:0051580)2.69973517
131adult behavior (GO:0030534)2.69467307
132cellular ketone body metabolic process (GO:0046950)2.67780188
133negative regulation of heart rate (GO:0010459)2.67225589
134glycerophospholipid catabolic process (GO:0046475)2.66918825
135regulation of synaptic transmission, GABAergic (GO:0032228)2.66671461
136response to amphetamine (GO:0001975)2.64503723
137protein complex biogenesis (GO:0070271)2.63432245
138regulation of calcium ion-dependent exocytosis (GO:0017158)2.63255766
139reflex (GO:0060004)2.61499991
140behavioral defense response (GO:0002209)2.60006448
141behavioral fear response (GO:0001662)2.60006448
142synaptic transmission, cholinergic (GO:0007271)2.59939597
143action potential (GO:0001508)2.59675804
144axon ensheathment in central nervous system (GO:0032291)2.54861584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49328541
2GBX2_23144817_ChIP-Seq_PC3_Human3.94917160
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12034222
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03277691
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87524521
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66824100
7VDR_22108803_ChIP-Seq_LS180_Human2.65158886
8REST_21632747_ChIP-Seq_MESCs_Mouse2.64022058
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60518409
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60518409
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58473489
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56715342
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55103423
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.47703576
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45453956
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45406135
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36967566
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36067734
19TAF15_26573619_Chip-Seq_HEK293_Human2.35741638
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.35215517
21DROSHA_22980978_ChIP-Seq_HELA_Human2.32535120
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24592567
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.19574422
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19558200
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.18890895
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05635696
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.03162478
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.01902757
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01663933
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00045392
31AR_21572438_ChIP-Seq_LNCaP_Human1.92525721
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89963255
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80924286
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78647294
35* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77167933
36SMAD4_21799915_ChIP-Seq_A2780_Human1.77018202
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.72839125
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66448189
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62926719
40* P300_19829295_ChIP-Seq_ESCs_Human1.59004510
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.54339724
42EWS_26573619_Chip-Seq_HEK293_Human1.54253805
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53026189
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47794271
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46618209
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43675404
47ZNF274_21170338_ChIP-Seq_K562_Hela1.43398395
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43266969
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43216236
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40572240
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39205845
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.39072596
53* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37830349
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37243577
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.36321891
56* STAT3_23295773_ChIP-Seq_U87_Human1.33381828
57RNF2_27304074_Chip-Seq_NSC_Mouse1.33021715
58IGF1R_20145208_ChIP-Seq_DFB_Human1.32663303
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31753698
60CBP_20019798_ChIP-Seq_JUKART_Human1.31505197
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31505197
62AR_25329375_ChIP-Seq_VCAP_Human1.30027267
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.28895059
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28787687
65TP53_22573176_ChIP-Seq_HFKS_Human1.28076100
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27883509
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27304512
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27291838
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25352429
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25273459
71* AR_19668381_ChIP-Seq_PC3_Human1.24034746
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.20901992
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20451486
74* TCF4_23295773_ChIP-Seq_U87_Human1.19615271
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18185785
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17961943
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17436770
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17246874
79* TCF4_22108803_ChIP-Seq_LS180_Human1.16730564
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13886424
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13537221
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13312794
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.12152363
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11667291
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.11079850
86NANOG_19829295_ChIP-Seq_ESCs_Human1.09716916
87SOX2_19829295_ChIP-Seq_ESCs_Human1.09716916
88* TAL1_26923725_Chip-Seq_HPCs_Mouse1.09701654
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.09316111
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09310309
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09278176
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09237631
93* JUN_21703547_ChIP-Seq_K562_Human1.09216606
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07560106
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07275041
96P53_22387025_ChIP-Seq_ESCs_Mouse1.07190530
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06397464
98ER_23166858_ChIP-Seq_MCF-7_Human1.06203975
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05674603
100* RUNX2_22187159_ChIP-Seq_PCA_Human1.05464447
101BCAT_22108803_ChIP-Seq_LS180_Human1.05459465
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05098145
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03603188
104* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03459401
105* SMAD3_21741376_ChIP-Seq_ESCs_Human1.03277802
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03085441
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.02854238
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02030515
109* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01885636
110HTT_18923047_ChIP-ChIP_STHdh_Human1.01296132
111AHR_22903824_ChIP-Seq_MCF-7_Human1.01116927
112RING1B_27294783_Chip-Seq_NPCs_Mouse0.98226237
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97871469
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97871469
115TP53_16413492_ChIP-PET_HCT116_Human0.97707593
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97232458
117* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97035255
118FUS_26573619_Chip-Seq_HEK293_Human0.96872162
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96529826
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95981135
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94804263
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93644691
123* KDM2B_26808549_Chip-Seq_REH_Human0.93515823
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93071228
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.92305953
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92209391
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.92203107
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.91846679
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.90333776
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90320984
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88420617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.37073933
2MP0003880_abnormal_central_pattern4.44249390
3MP0003635_abnormal_synaptic_transmissio3.97447841
4MP0009046_muscle_twitch3.82017962
5MP0004270_analgesia3.48626418
6MP0001968_abnormal_touch/_nociception3.41010180
7MP0009745_abnormal_behavioral_response3.15934915
8MP0002064_seizures3.14689362
9MP0002063_abnormal_learning/memory/cond3.00722941
10MP0002736_abnormal_nociception_after2.97754764
11MP0003122_maternal_imprinting2.97257361
12MP0002734_abnormal_mechanical_nocicepti2.82463669
13MP0002272_abnormal_nervous_system2.80264233
14MP0002572_abnormal_emotion/affect_behav2.75240505
15MP0001486_abnormal_startle_reflex2.57989495
16MP0005423_abnormal_somatic_nervous2.52082885
17MP0008877_abnormal_DNA_methylation2.44488723
18MP0002735_abnormal_chemical_nociception2.40283562
19MP0001501_abnormal_sleep_pattern2.34470567
20MP0001984_abnormal_olfaction2.33292991
21MP0002067_abnormal_sensory_capabilities2.29057208
22MP0001440_abnormal_grooming_behavior2.28624585
23MP0008569_lethality_at_weaning2.15119501
24MP0006276_abnormal_autonomic_nervous2.14359705
25MP0002733_abnormal_thermal_nociception2.10907427
26MP0001529_abnormal_vocalization2.08841515
27MP0002184_abnormal_innervation2.06976137
28MP0001970_abnormal_pain_threshold2.01882917
29MP0005645_abnormal_hypothalamus_physiol1.90347273
30MP0004924_abnormal_behavior1.86199211
31MP0005386_behavior/neurological_phenoty1.86199211
32MP0000778_abnormal_nervous_system1.84666910
33MP0002102_abnormal_ear_morphology1.82844113
34MP0002557_abnormal_social/conspecific_i1.81938332
35MP0005646_abnormal_pituitary_gland1.76965785
36MP0004147_increased_porphyrin_level1.58817249
37MP0004811_abnormal_neuron_physiology1.56000734
38MP0000955_abnormal_spinal_cord1.55834175
39MP0006292_abnormal_olfactory_placode1.53529910
40MP0004858_abnormal_nervous_system1.52060382
41MP0003879_abnormal_hair_cell1.51272657
42MP0004142_abnormal_muscle_tone1.48969326
43MP0002066_abnormal_motor_capabilities/c1.45539742
44MP0002909_abnormal_adrenal_gland1.44575187
45MP0002882_abnormal_neuron_morphology1.44382280
46MP0003329_amyloid_beta_deposits1.43600533
47MP0001502_abnormal_circadian_rhythm1.43096642
48MP0008875_abnormal_xenobiotic_pharmacok1.40116967
49MP0001485_abnormal_pinna_reflex1.39491779
50MP0005551_abnormal_eye_electrophysiolog1.36875477
51MP0001986_abnormal_taste_sensitivity1.33969661
52MP0002822_catalepsy1.29625539
53MP0000751_myopathy1.29315445
54MP0003121_genomic_imprinting1.28793631
55MP0002876_abnormal_thyroid_physiology1.24795711
56MP0004145_abnormal_muscle_electrophysio1.23565477
57MP0003787_abnormal_imprinting1.22600636
58MP0003633_abnormal_nervous_system1.20996839
59MP0009780_abnormal_chondrocyte_physiolo1.17019505
60MP0003631_nervous_system_phenotype1.09072743
61MP0002152_abnormal_brain_morphology1.08629553
62MP0004133_heterotaxia1.07804910
63MP0000427_abnormal_hair_cycle1.06485281
64MP0002229_neurodegeneration1.06004794
65MP0003011_delayed_dark_adaptation1.03872147
66MP0001905_abnormal_dopamine_level1.01816945
67MP0004043_abnormal_pH_regulation1.01810119
68MP0004742_abnormal_vestibular_system1.01181954
69MP0003195_calcinosis1.00533024
70MP0002837_dystrophic_cardiac_calcinosis0.99636646
71MP0001188_hyperpigmentation0.98642976
72MP0004885_abnormal_endolymph0.98293561
73MP0008872_abnormal_physiological_respon0.97446707
74MP0005535_abnormal_body_temperature0.95148516
75MP0001963_abnormal_hearing_physiology0.91876168
76MP0004233_abnormal_muscle_weight0.91386130
77MP0002069_abnormal_eating/drinking_beha0.90529629
78MP0005379_endocrine/exocrine_gland_phen0.90255339
79MP0002752_abnormal_somatic_nervous0.89978502
80MP0002234_abnormal_pharynx_morphology0.89977132
81MP0003283_abnormal_digestive_organ0.89424774
82MP0003632_abnormal_nervous_system0.88832538
83MP0002653_abnormal_ependyma_morphology0.88821336
84MP0001299_abnormal_eye_distance/0.87782205
85MP0004085_abnormal_heartbeat0.84630111
86MP0005410_abnormal_fertilization0.84314428
87MP0000013_abnormal_adipose_tissue0.83754533
88MP0005187_abnormal_penis_morphology0.81615950
89MP0004215_abnormal_myocardial_fiber0.81347250
90MP0000569_abnormal_digit_pigmentation0.81314912
91MP0002163_abnormal_gland_morphology0.80413668
92MP0008874_decreased_physiological_sensi0.79979513
93MP0005623_abnormal_meninges_morphology0.79783839
94MP0000631_abnormal_neuroendocrine_gland0.79346149
95MP0010386_abnormal_urinary_bladder0.79008205
96MP0002160_abnormal_reproductive_system0.78682953
97MP0002090_abnormal_vision0.78542826
98MP0003634_abnormal_glial_cell0.75161283
99MP0005394_taste/olfaction_phenotype0.74761963
100MP0005499_abnormal_olfactory_system0.74761963
101MP0005195_abnormal_posterior_eye0.73521785
102MP0002928_abnormal_bile_duct0.71121742
103MP0001177_atelectasis0.70680180
104MP0002938_white_spotting0.70506888
105MP0005174_abnormal_tail_pigmentation0.70413177
106MP0003698_abnormal_male_reproductive0.70040896
107MP0003137_abnormal_impulse_conducting0.67712165
108MP0008789_abnormal_olfactory_epithelium0.67549569
109MP0001943_abnormal_respiration0.66157605
110MP0000920_abnormal_myelination0.66128528
111MP0003690_abnormal_glial_cell0.64267661
112MP0002638_abnormal_pupillary_reflex0.63798189
113MP0006072_abnormal_retinal_apoptosis0.62675287
114MP0010769_abnormal_survival0.60617831
115MP0003183_abnormal_peptide_metabolism0.60589088
116MP0010770_preweaning_lethality0.60274918
117MP0002082_postnatal_lethality0.60274918
118MP0008961_abnormal_basal_metabolism0.60131334
119MP0010768_mortality/aging0.57776159
120MP0003045_fibrosis0.57464449
121MP0005253_abnormal_eye_physiology0.57192659
122MP0004484_altered_response_of0.56660309
123MP0003646_muscle_fatigue0.55298756
124MP0000026_abnormal_inner_ear0.54336385
125MP0000534_abnormal_ureter_morphology0.53489470
126MP0000604_amyloidosis0.52838502
127MP0003956_abnormal_body_size0.52760936

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.17678609
2Myokymia (HP:0002411)5.75980874
3Atonic seizures (HP:0010819)5.66350847
4Focal seizures (HP:0007359)5.62616817
5Progressive cerebellar ataxia (HP:0002073)5.07025714
6Febrile seizures (HP:0002373)5.03524483
7Epileptic encephalopathy (HP:0200134)4.87958131
8Action tremor (HP:0002345)4.73609861
9Absence seizures (HP:0002121)4.70484055
10Visual hallucinations (HP:0002367)4.66295237
11Dialeptic seizures (HP:0011146)4.06890648
12Generalized tonic-clonic seizures (HP:0002069)3.91984244
13Gaze-evoked nystagmus (HP:0000640)3.81317485
14Abnormal eating behavior (HP:0100738)3.64092609
15Polyphagia (HP:0002591)3.52528369
16Failure to thrive in infancy (HP:0001531)3.50822868
17Pancreatic fibrosis (HP:0100732)3.37704087
18Truncal ataxia (HP:0002078)3.32857264
19Dysdiadochokinesis (HP:0002075)3.31818047
20Pancreatic cysts (HP:0001737)3.29952258
21Type II lissencephaly (HP:0007260)3.19705238
22Abnormality of midbrain morphology (HP:0002418)3.17760005
23Molar tooth sign on MRI (HP:0002419)3.17760005
24Broad-based gait (HP:0002136)3.12130813
25Medial flaring of the eyebrow (HP:0010747)3.11985494
26Dysmetric saccades (HP:0000641)3.03716830
27Depression (HP:0000716)3.03456119
28Nephronophthisis (HP:0000090)2.98936240
29Supranuclear gaze palsy (HP:0000605)2.96360410
30True hermaphroditism (HP:0010459)2.94566804
31Impaired smooth pursuit (HP:0007772)2.90734194
32Impaired vibration sensation in the lower limbs (HP:0002166)2.89757885
33Ankle clonus (HP:0011448)2.88758750
34Genetic anticipation (HP:0003743)2.85726924
35Dysmetria (HP:0001310)2.85181102
36Urinary bladder sphincter dysfunction (HP:0002839)2.83291468
37Poor eye contact (HP:0000817)2.82128057
38Limb dystonia (HP:0002451)2.78732239
39Anxiety (HP:0000739)2.76981301
40Diplopia (HP:0000651)2.76458796
41Abnormality of binocular vision (HP:0011514)2.76458796
42Scanning speech (HP:0002168)2.73264200
43Acute necrotizing encephalopathy (HP:0006965)2.66574774
44Congenital stationary night blindness (HP:0007642)2.65911190
45Status epilepticus (HP:0002133)2.64496643
46Abnormality of ocular smooth pursuit (HP:0000617)2.63363131
47Fetal akinesia sequence (HP:0001989)2.60222376
48Impaired social interactions (HP:0000735)2.57449301
49Abnormal social behavior (HP:0012433)2.57449301
50Torticollis (HP:0000473)2.57290657
51Pheochromocytoma (HP:0002666)2.56425444
52Epileptiform EEG discharges (HP:0011182)2.56141456
53Excessive salivation (HP:0003781)2.55544778
54Drooling (HP:0002307)2.55544778
55Hemiplegia (HP:0002301)2.54498222
56Absent speech (HP:0001344)2.54405671
57Postural instability (HP:0002172)2.54255471
58Postural tremor (HP:0002174)2.52894004
59Hemiparesis (HP:0001269)2.52841572
60Chronic hepatic failure (HP:0100626)2.51638402
61Abnormality of the renal medulla (HP:0100957)2.51610534
62Hyperventilation (HP:0002883)2.51145832
63Progressive macrocephaly (HP:0004481)2.49267126
64Mutism (HP:0002300)2.47233183
65Abnormality of the corticospinal tract (HP:0002492)2.47072643
66Nephrogenic diabetes insipidus (HP:0009806)2.44063577
67Retinal dysplasia (HP:0007973)2.42523333
68Abnormal hair whorl (HP:0010721)2.42264390
69EEG with generalized epileptiform discharges (HP:0011198)2.42239133
70Focal dystonia (HP:0004373)2.42027800
71Sleep apnea (HP:0010535)2.40485133
72Amblyopia (HP:0000646)2.40260620
73Agitation (HP:0000713)2.39015629
74Spastic gait (HP:0002064)2.36725933
75Esotropia (HP:0000565)2.33553993
76Lissencephaly (HP:0001339)2.33295009
77Bradykinesia (HP:0002067)2.33218074
78Genital tract atresia (HP:0001827)2.30434948
79Mitochondrial inheritance (HP:0001427)2.30352707
80Insidious onset (HP:0003587)2.30162269
81Termporal pattern (HP:0011008)2.30162269
82Narrow nasal bridge (HP:0000446)2.29827074
83Abnormal drinking behavior (HP:0030082)2.29810810
84Polydipsia (HP:0001959)2.29810810
85Abnormality of the labia minora (HP:0012880)2.27810450
86Urinary urgency (HP:0000012)2.27232890
87Acute encephalopathy (HP:0006846)2.26282294
88Papilledema (HP:0001085)2.26244507
89Hypoventilation (HP:0002791)2.25221675
90Craniofacial dystonia (HP:0012179)2.24377254
91Neuroendocrine neoplasm (HP:0100634)2.23285454
92Intention tremor (HP:0002080)2.22275266
93Blue irides (HP:0000635)2.22075194
94Abnormal mitochondria in muscle tissue (HP:0008316)2.21842285
95Abnormality of the renal cortex (HP:0011035)2.21538076
96Hypsarrhythmia (HP:0002521)2.21209750
97Specific learning disability (HP:0001328)2.18870544
98Increased CSF lactate (HP:0002490)2.17836418
99Vaginal atresia (HP:0000148)2.13429273
100Abolished electroretinogram (ERG) (HP:0000550)2.13196907
101Gait imbalance (HP:0002141)2.13027937
102Impaired vibratory sensation (HP:0002495)2.10168066
103Abnormality of the lower motor neuron (HP:0002366)2.09508736
104Cystic liver disease (HP:0006706)2.08068061
105Optic nerve hypoplasia (HP:0000609)2.05448953
106Attenuation of retinal blood vessels (HP:0007843)2.04846523
107Progressive inability to walk (HP:0002505)2.01066107
108Large for gestational age (HP:0001520)1.99879568
109Pachygyria (HP:0001302)1.98290505
110Akinesia (HP:0002304)1.98012084
111Inability to walk (HP:0002540)1.97467315
112Open mouth (HP:0000194)1.96621858
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.95870772
114Optic disc pallor (HP:0000543)1.93501704
115Sclerocornea (HP:0000647)1.93102062
116Dyskinesia (HP:0100660)1.92542940
117Poor suck (HP:0002033)1.90776493
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89444012
119Lower limb muscle weakness (HP:0007340)1.89158796
120Tubular atrophy (HP:0000092)1.88479491
121Spastic tetraplegia (HP:0002510)1.88476443
122Degeneration of the lateral corticospinal tracts (HP:0002314)1.86685973
123Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86685973
124Incomplete penetrance (HP:0003829)1.86340103
125Lipid accumulation in hepatocytes (HP:0006561)1.86078730
126Aqueductal stenosis (HP:0002410)1.85993698
127Abnormality of macular pigmentation (HP:0008002)1.85670331
128Generalized myoclonic seizures (HP:0002123)1.85109867
129Spinal canal stenosis (HP:0003416)1.85072073
130Stereotypic behavior (HP:0000733)1.84788438
131Polyuria (HP:0000103)1.83946022
132Psychosis (HP:0000709)1.83836969
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.83811596
134Methylmalonic acidemia (HP:0002912)1.83422516
1353-Methylglutaconic aciduria (HP:0003535)1.82300250
136Protruding tongue (HP:0010808)1.81878755
137Abnormality of saccadic eye movements (HP:0000570)1.81548866
138Cerebellar dysplasia (HP:0007033)1.80973392
139Impaired pain sensation (HP:0007328)1.79974054
140Abnormality of pain sensation (HP:0010832)1.79974054
141Increased hepatocellular lipid droplets (HP:0006565)1.79716702
142Labial hypoplasia (HP:0000066)1.79177809
143Hypothermia (HP:0002045)1.78156480
144Congenital primary aphakia (HP:0007707)1.77620202
145Clonus (HP:0002169)1.77246829
146Ventricular fibrillation (HP:0001663)1.76904334
147Oligomenorrhea (HP:0000876)1.73675219
148Pendular nystagmus (HP:0012043)1.73151124
149Neuronal loss in central nervous system (HP:0002529)1.72624502
150Abnormality of salivation (HP:0100755)1.71858328
151Short tibia (HP:0005736)1.71841964
152Oligodactyly (hands) (HP:0001180)1.71840225
153Muscular hypotonia of the trunk (HP:0008936)1.70734805
154Ketoacidosis (HP:0001993)1.70550414
155Abnormal rod and cone electroretinograms (HP:0008323)1.69531218
156Severe muscular hypotonia (HP:0006829)1.68368174
157Hypomagnesemia (HP:0002917)1.67533282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.03074209
2MAP3K43.99863145
3MAP3K93.86050844
4FRK3.82191614
5MAP2K73.50031353
6MAP3K122.97872517
7CASK2.97567281
8MARK12.86681718
9MAP2K42.64450778
10MINK12.55243723
11CDK192.44808553
12EPHA42.38717663
13MAP4K22.26367548
14PAK62.21152978
15NTRK22.13066061
16ADRBK22.06738483
17BMPR1B1.97448163
18PRPF4B1.95705308
19DAPK21.91724700
20STK381.66216161
21GRK11.65899282
22MAPK131.48317148
23WNK41.47846025
24TRIM281.47522859
25PLK21.47121830
26TNIK1.46225781
27CAMKK11.40326714
28CAMKK21.36464028
29CDK51.33990731
30INSRR1.33702479
31GRK51.33400654
32KSR11.32694590
33NTRK11.30949897
34DAPK11.30760413
35RIPK41.28905103
36OXSR11.27311035
37LIMK11.23184536
38ZAK1.22512101
39CSNK1G31.22299685
40PRKCG1.19030401
41DYRK21.17288957
42CSNK1G11.16190425
43KSR21.12610834
44UHMK11.12443804
45CDK181.08521184
46ACVR1B1.07714359
47PHKG21.06380293
48PHKG11.06380293
49STK391.06281681
50LATS21.05811316
51CSNK1A1L1.05090974
52TLK11.04839464
53CDK151.03085222
54NUAK11.01766681
55CAMK2A1.01194053
56SIK31.00143232
57PNCK0.98756058
58CDK140.97268309
59MUSK0.96860255
60AKT30.95074074
61BCR0.93695112
62SGK4940.91821682
63SGK2230.91821682
64TYRO30.90571168
65SGK20.88968112
66CDK11A0.88645336
67TAOK30.88233969
68WNK30.85642581
69ARAF0.85122426
70NEK10.84996982
71CAMK10.84019415
72CAMK1G0.83982499
73ERBB30.83817894
74DDR20.83141222
75MKNK20.82885680
76WNK10.82818577
77SIK20.82402492
78RET0.82280912
79PRKCH0.79044828
80FES0.76836255
81TIE10.76813814
82CCNB10.74797899
83CAMK2B0.74140445
84PAK30.72763658
85CSNK1G20.72367634
86STK110.72341415
87PRKD30.69783103
88FGFR20.69530526
89PKN10.68996199
90LMTK20.68769127
91EPHA30.67023027
92TXK0.66945087
93MAP3K60.65014191
94SGK30.65005107
95RIPK10.64227935
96PRKCE0.64049811
97STK160.63575062
98GRK70.63415015
99TAOK20.63127236
100FER0.62717925
101CSNK1A10.59908445
102CDC42BPA0.59128694
103PRKACA0.58727583
104PIK3CA0.58638684
105CAMK2D0.57178497
106ROCK20.56175279
107SGK10.55601908
108DYRK1A0.54995642
109PRKCA0.52219862
110PDK10.51932273
111NME10.51301737
112RPS6KA30.49733512
113BCKDK0.49571302
114PTK2B0.49267259
115ADRBK10.49147518
116CAMK2G0.48252204
117PRKCQ0.47822446
118FGR0.47577290
119ALK0.47424098
120PDK30.47323349
121PDK40.47323349
122BMPR20.46987806
123CAMK40.46390113
124CSNK1D0.44270947
125MARK20.42115739
126PDPK10.41967697
127CAMK1D0.41134421
128VRK10.40196519
129TAOK10.40000308
130PRKCB0.39780583
131MAP2K60.39622022
132PRKCZ0.39611231
133PLK30.38908352
134STK38L0.38342900
135MAP3K20.37730866
136PRKG10.37607771
137PINK10.37517703
138FYN0.37316981
139PRKCI0.35757960
140CSNK1E0.34456483
141PRKAA10.30867828
142PRKACB0.29622034

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26289864
2Synaptic vesicle cycle_Homo sapiens_hsa047213.70507316
3GABAergic synapse_Homo sapiens_hsa047272.90991715
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87917296
5Morphine addiction_Homo sapiens_hsa050322.69575079
6Olfactory transduction_Homo sapiens_hsa047402.62362747
7Circadian entrainment_Homo sapiens_hsa047132.61211107
8Glutamatergic synapse_Homo sapiens_hsa047242.53639861
9Long-term potentiation_Homo sapiens_hsa047202.31648913
10Amphetamine addiction_Homo sapiens_hsa050312.26640856
11Dopaminergic synapse_Homo sapiens_hsa047282.19311206
12Insulin secretion_Homo sapiens_hsa049112.15923678
13Salivary secretion_Homo sapiens_hsa049702.12773317
14Taste transduction_Homo sapiens_hsa047422.12497655
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07893299
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01329486
17Collecting duct acid secretion_Homo sapiens_hsa049661.93486905
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86926356
19Butanoate metabolism_Homo sapiens_hsa006501.85227378
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81920959
21Serotonergic synapse_Homo sapiens_hsa047261.71970267
22Long-term depression_Homo sapiens_hsa047301.67041742
23Gastric acid secretion_Homo sapiens_hsa049711.66778781
24Cholinergic synapse_Homo sapiens_hsa047251.66083426
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.64856676
26Cocaine addiction_Homo sapiens_hsa050301.58582632
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58032800
28Renin secretion_Homo sapiens_hsa049241.57772339
29Protein export_Homo sapiens_hsa030601.57152956
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54404600
31Calcium signaling pathway_Homo sapiens_hsa040201.52097340
32Oxytocin signaling pathway_Homo sapiens_hsa049211.46892733
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35227953
34Gap junction_Homo sapiens_hsa045401.31594798
35GnRH signaling pathway_Homo sapiens_hsa049121.30065447
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29509667
37Linoleic acid metabolism_Homo sapiens_hsa005911.29430252
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27328444
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23012259
40Type II diabetes mellitus_Homo sapiens_hsa049301.19777835
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18632034
42cAMP signaling pathway_Homo sapiens_hsa040241.16581129
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16254500
44Phototransduction_Homo sapiens_hsa047441.16018196
45Vibrio cholerae infection_Homo sapiens_hsa051101.15423621
46Cardiac muscle contraction_Homo sapiens_hsa042601.13059995
47Estrogen signaling pathway_Homo sapiens_hsa049151.11903762
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08948716
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08867961
50Axon guidance_Homo sapiens_hsa043601.08786961
51Ether lipid metabolism_Homo sapiens_hsa005651.08766196
52Propanoate metabolism_Homo sapiens_hsa006401.01881907
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00174758
54Regulation of autophagy_Homo sapiens_hsa041400.96640880
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95620524
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94892824
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91651246
58ErbB signaling pathway_Homo sapiens_hsa040120.91245003
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89743186
60Tryptophan metabolism_Homo sapiens_hsa003800.88538828
61Melanogenesis_Homo sapiens_hsa049160.86595144
62Thyroid hormone synthesis_Homo sapiens_hsa049180.85223277
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84540766
64Glioma_Homo sapiens_hsa052140.78893817
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78665081
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.78019277
67Pancreatic secretion_Homo sapiens_hsa049720.77260417
68Dilated cardiomyopathy_Homo sapiens_hsa054140.75409610
69Peroxisome_Homo sapiens_hsa041460.75302079
70Selenocompound metabolism_Homo sapiens_hsa004500.72694381
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72412879
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71764870
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69887760
74MAPK signaling pathway_Homo sapiens_hsa040100.67785011
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.67520612
76Oocyte meiosis_Homo sapiens_hsa041140.67295518
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65481594
78Dorso-ventral axis formation_Homo sapiens_hsa043200.64910466
79Oxidative phosphorylation_Homo sapiens_hsa001900.64410833
80beta-Alanine metabolism_Homo sapiens_hsa004100.63929413
81Caffeine metabolism_Homo sapiens_hsa002320.63182370
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.61599301
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61007668
84Basal transcription factors_Homo sapiens_hsa030220.60938668
85ABC transporters_Homo sapiens_hsa020100.59740233
86Alzheimers disease_Homo sapiens_hsa050100.58592687
87Glucagon signaling pathway_Homo sapiens_hsa049220.58511576
88Sulfur relay system_Homo sapiens_hsa041220.58422919
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58249628
90Fatty acid elongation_Homo sapiens_hsa000620.58099975
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56682453
92RNA polymerase_Homo sapiens_hsa030200.55180616
93Circadian rhythm_Homo sapiens_hsa047100.55122942
94Inositol phosphate metabolism_Homo sapiens_hsa005620.54446402
95Mineral absorption_Homo sapiens_hsa049780.54401919
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54196101
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53924976
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52861934
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52773347
100Alcoholism_Homo sapiens_hsa050340.51838404
101Choline metabolism in cancer_Homo sapiens_hsa052310.51617320
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50902856
103Bile secretion_Homo sapiens_hsa049760.50514091
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.47968053
105Ras signaling pathway_Homo sapiens_hsa040140.47763943
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45830121
107Vitamin B6 metabolism_Homo sapiens_hsa007500.44950145
108Wnt signaling pathway_Homo sapiens_hsa043100.42945835
109Fatty acid metabolism_Homo sapiens_hsa012120.41955761
110Rap1 signaling pathway_Homo sapiens_hsa040150.41459394
111Parkinsons disease_Homo sapiens_hsa050120.41228879
112RNA degradation_Homo sapiens_hsa030180.41113396
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40239808
114Glycerolipid metabolism_Homo sapiens_hsa005610.39375547
115Metabolic pathways_Homo sapiens_hsa011000.38222229
116Ovarian steroidogenesis_Homo sapiens_hsa049130.38055510
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37793751
118Type I diabetes mellitus_Homo sapiens_hsa049400.37552480
119Retinol metabolism_Homo sapiens_hsa008300.36652396
120Nitrogen metabolism_Homo sapiens_hsa009100.36473741
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36192651
122Fatty acid biosynthesis_Homo sapiens_hsa000610.35755525
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35186401
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.34769195
125Chemical carcinogenesis_Homo sapiens_hsa052040.34336484
126Insulin signaling pathway_Homo sapiens_hsa049100.34325122
127Arginine biosynthesis_Homo sapiens_hsa002200.33873838
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.33437636
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32962947
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32299018
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31823985
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31703458
133mTOR signaling pathway_Homo sapiens_hsa041500.31333791
134Rheumatoid arthritis_Homo sapiens_hsa053230.30621952
135Endometrial cancer_Homo sapiens_hsa052130.27586771
136VEGF signaling pathway_Homo sapiens_hsa043700.27397853
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26387748
138Phagosome_Homo sapiens_hsa041450.26332007
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25226136
140Endocytosis_Homo sapiens_hsa041440.24101363
141Huntingtons disease_Homo sapiens_hsa050160.23932203

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