CDH15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1myotube cell development (GO:0014904)8.81000252
2positive regulation of myotube differentiation (GO:0010831)8.76673436
3skeletal muscle contraction (GO:0003009)8.69528184
4musculoskeletal movement (GO:0050881)8.62204711
5multicellular organismal movement (GO:0050879)8.62204711
6regulation of syncytium formation by plasma membrane fusion (GO:0060142)7.94093287
7muscle filament sliding (GO:0030049)7.90245496
8actin-myosin filament sliding (GO:0033275)7.90245496
9response to inactivity (GO:0014854)7.52224913
10myoblast fusion (GO:0007520)7.33838961
11positive regulation of skeletal muscle tissue development (GO:0048643)7.15334254
12striated muscle atrophy (GO:0014891)7.00592046
13syncytium formation by plasma membrane fusion (GO:0000768)6.92595127
14plasma membrane repair (GO:0001778)6.84965820
15actin-mediated cell contraction (GO:0070252)6.76500685
16syncytium formation (GO:0006949)6.37438507
17positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)6.29347186
18response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.21518512
19muscle atrophy (GO:0014889)6.10816927
20myotube differentiation (GO:0014902)5.94309509
21muscle fiber development (GO:0048747)5.64405125
22positive regulation of myoblast differentiation (GO:0045663)5.55739186
23muscle cell cellular homeostasis (GO:0046716)5.52734712
24skeletal muscle tissue development (GO:0007519)5.35232302
25neuromuscular synaptic transmission (GO:0007274)5.31129401
26actin filament-based movement (GO:0030048)5.28240672
27sarcoplasmic reticulum calcium ion transport (GO:0070296)4.97028947
28cellular response to estradiol stimulus (GO:0071392)4.82196460
29myofibril assembly (GO:0030239)4.72044937
30regulation of skeletal muscle contraction (GO:0014819)4.70801373
31postsynaptic membrane organization (GO:0001941)4.70065600
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.67446980
33muscle organ development (GO:0007517)4.55919568
34response to muscle activity (GO:0014850)4.52459534
35regulation of skeletal muscle cell differentiation (GO:2001014)4.49663572
36muscle structure development (GO:0061061)4.42095626
37organ induction (GO:0001759)4.34234657
38neuromuscular junction development (GO:0007528)4.27600287
39sarcomere organization (GO:0045214)4.26479478
40striated muscle cell development (GO:0055002)4.24515671
41synaptic transmission, cholinergic (GO:0007271)4.18241711
42striated muscle contraction (GO:0006941)4.18064590
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.17614249
44mRNA transcription from RNA polymerase II promoter (GO:0042789)4.03791046
45regulation of relaxation of muscle (GO:1901077)3.98969231
46muscle cell development (GO:0055001)3.93320036
47behavioral response to nicotine (GO:0035095)3.93044904
48positive regulation of striated muscle cell differentiation (GO:0051155)3.90601341
49mRNA transcription (GO:0009299)3.89590365
50regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.88560460
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.87779963
52regulation of membrane repolarization (GO:0060306)3.83848809
53response to gravity (GO:0009629)3.81836767
54skeletal muscle tissue regeneration (GO:0043403)3.80527276
55regulation of sarcomere organization (GO:0060297)3.79472527
56muscle contraction (GO:0006936)3.76486536
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.73838856
58regulation of striated muscle contraction (GO:0006942)3.72873245
59regulation of protein heterodimerization activity (GO:0043497)3.65309968
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.63640294
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.61904323
62embryonic camera-type eye development (GO:0031076)3.60449838
63striated muscle tissue development (GO:0014706)3.57967499
64cardiac myofibril assembly (GO:0055003)3.53075869
65negative regulation of protein localization to cell surface (GO:2000009)3.50662005
66regulation of myotube differentiation (GO:0010830)3.49591099
67regulation of action potential (GO:0098900)3.47125570
68striated muscle adaptation (GO:0014888)3.45461281
69cardiac muscle contraction (GO:0060048)3.45063978
70skeletal muscle adaptation (GO:0043501)3.42561004
71muscle system process (GO:0003012)3.40983961
72negative regulation of potassium ion transmembrane transport (GO:1901380)3.36497620
73embryonic retina morphogenesis in camera-type eye (GO:0060059)3.35086759
74actomyosin structure organization (GO:0031032)3.34965128
75negative regulation of gluconeogenesis (GO:0045721)3.34587378
76* positive regulation of muscle cell differentiation (GO:0051149)3.30665553
77positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.30335764
78metanephric mesenchyme development (GO:0072075)3.29282881
79negative regulation of cell size (GO:0045792)3.28485493
80embryonic body morphogenesis (GO:0010172)3.26263092
81muscle tissue development (GO:0060537)3.23066987
82skeletal muscle cell differentiation (GO:0035914)3.13966541
83plasma membrane fusion (GO:0045026)3.10739823
84body morphogenesis (GO:0010171)3.08258047
85membrane depolarization during action potential (GO:0086010)3.06292857
86cellular response to estrogen stimulus (GO:0071391)3.01268261
87regulation of cell communication by electrical coupling (GO:0010649)2.98797403
88negative regulation of potassium ion transport (GO:0043267)2.94057471
89neuronal action potential propagation (GO:0019227)2.93340878
90regulation of actin filament-based movement (GO:1903115)2.91253700
91positive regulation of astrocyte differentiation (GO:0048711)2.91231939
92regulation of skeletal muscle tissue development (GO:0048641)2.89413154
93myoblast migration (GO:0051451)2.86516964
94myelination in peripheral nervous system (GO:0022011)2.86440090
95peripheral nervous system axon ensheathment (GO:0032292)2.86440090
96lung epithelium development (GO:0060428)2.85044734
97positive regulation of action potential (GO:0045760)2.84317218
98collagen fibril organization (GO:0030199)2.84020375
99endodermal cell differentiation (GO:0035987)2.83983084
100positive regulation of protein depolymerization (GO:1901881)2.83714663
101basement membrane organization (GO:0071711)2.83709716
102kidney mesenchyme development (GO:0072074)2.82764489
103negative regulation of fatty acid transport (GO:2000192)2.81287270
104regulation of muscle system process (GO:0090257)2.80508528
105face morphogenesis (GO:0060325)2.79546277
106regulation of skeletal muscle fiber development (GO:0048742)2.79311487
107response to activity (GO:0014823)2.73987788
108negative regulation of muscle hypertrophy (GO:0014741)2.72883982
109regulation of calcium ion transmembrane transport (GO:1903169)2.72425713
110regulation of p38MAPK cascade (GO:1900744)2.71176310
111regulation of cardioblast proliferation (GO:0003264)2.71074184
112regulation of secondary heart field cardioblast proliferation (GO:0003266)2.71074184
113regulation of myoblast differentiation (GO:0045661)2.69893823
114negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69001418
115muscle tissue morphogenesis (GO:0060415)2.67534493
116muscle adaptation (GO:0043500)2.67525188
117response to lithium ion (GO:0010226)2.67400866
118cellular response to lithium ion (GO:0071285)2.65881074
119neuronal action potential (GO:0019228)2.65757447
120regulation of muscle adaptation (GO:0043502)2.64529564
121creatine metabolic process (GO:0006600)2.63795360
122regulation of potassium ion transmembrane transporter activity (GO:1901016)2.63166536
123regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.62865230
124regulation of organ formation (GO:0003156)2.61778060
125replacement ossification (GO:0036075)2.60484824
126endochondral ossification (GO:0001958)2.60484824
127epithelial cell-cell adhesion (GO:0090136)2.59076617
128regulation of muscle contraction (GO:0006937)2.58141105
129regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.57875890
130heart process (GO:0003015)2.53916543
131heart contraction (GO:0060047)2.53916543
132positive regulation of striated muscle tissue development (GO:0045844)2.52938644
133positive regulation of muscle organ development (GO:0048636)2.52938644
134regulation of calcium ion transmembrane transporter activity (GO:1901019)2.50891930
135response to caffeine (GO:0031000)2.49646044
136negative regulation of nitric-oxide synthase activity (GO:0051001)2.49511816
137regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.46099578
138muscle cell fate commitment (GO:0042693)11.0954108
139skeletal muscle fiber development (GO:0048741)10.4660933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse3.59617513
2EZH2_22144423_ChIP-Seq_EOC_Human3.55449268
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.48164066
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.36883544
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.25074729
6ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.88215602
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77199340
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.73250507
9GBX2_23144817_ChIP-Seq_PC3_Human2.48553547
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39566838
11WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.39057216
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.38196092
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.35506367
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33180542
15CLOCK_20551151_ChIP-Seq_293T_Human2.29309877
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27689519
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25714263
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25317433
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.15164472
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.10148925
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09828551
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.08948750
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.06159258
24ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03255195
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.02600898
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97733647
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.96556903
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.91440720
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89549753
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.88160217
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84350047
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84350047
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83911439
34TP53_16413492_ChIP-PET_HCT116_Human1.83072583
35IGF1R_20145208_ChIP-Seq_DFB_Human1.81013259
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80725197
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.80437894
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.80290623
39VDR_22108803_ChIP-Seq_LS180_Human1.73433917
40* KDM2B_26808549_Chip-Seq_K562_Human1.72889389
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.72374422
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.72019597
43ZNF263_19887448_ChIP-Seq_K562_Human1.71829036
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70751821
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.70369937
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65020479
47CJUN_26792858_Chip-Seq_BT549_Human1.63259885
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.60606101
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59247396
50* TBX20_22080862_ChIP-Seq_HEART_Mouse1.58580387
51* TBX20_22328084_ChIP-Seq_HEART_Mouse1.58580387
52* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57450171
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.56927244
54LXR_22292898_ChIP-Seq_THP-1_Human1.52572241
55* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52413641
56REST_21632747_ChIP-Seq_MESCs_Mouse1.52309708
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49856797
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.49846878
59* KDM2B_26808549_Chip-Seq_DND41_Human1.49284724
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48578431
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.46872522
62MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.46758187
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46292089
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45581353
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.45387256
66* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45370983
67SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.43727719
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43532771
69* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42674982
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41323992
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40510664
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39939039
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38509822
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38207346
75BRD4_25478319_ChIP-Seq_HGPS_Human1.38170340
76ATF3_27146783_Chip-Seq_COLON_Human1.38118766
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37431274
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36448650
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35837288
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34875533
81AR_21572438_ChIP-Seq_LNCaP_Human1.33812728
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33659981
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.33106541
84RACK7_27058665_Chip-Seq_MCF-7_Human1.32916329
85TP53_22127205_ChIP-Seq_IMR90_Human1.32702443
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.31551981
87FUS_26573619_Chip-Seq_HEK293_Human1.31440868
88P300_19829295_ChIP-Seq_ESCs_Human1.31237374
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.30979647
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.30589709
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30027604
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.29912915
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29442454
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27754981
95P53_22387025_ChIP-Seq_ESCs_Mouse1.27006269
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26936367
97ER_23166858_ChIP-Seq_MCF-7_Human1.24868153
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.24513691
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24318527
100CBP_20019798_ChIP-Seq_JUKART_Human1.23338220
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23338220
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23311640
103SMAD4_21799915_ChIP-Seq_A2780_Human1.22984261
104ZNF274_21170338_ChIP-Seq_K562_Hela1.22776584
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20879532
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20719847
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18801597
108TCF7_22412390_ChIP-Seq_EML_Mouse1.18796324
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18405941
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17697964
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16790443
112DROSHA_22980978_ChIP-Seq_HELA_Human1.15988349
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15574886
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15303759
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14445640
116UBF1/2_26484160_Chip-Seq_HMECs_Human1.14131866
117TAF15_26573619_Chip-Seq_HEK293_Human1.13455434
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13013631
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12836456
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12078745
121SOX2_19829295_ChIP-Seq_ESCs_Human1.11413395
122NANOG_19829295_ChIP-Seq_ESCs_Human1.11413395
123NANOG_18555785_Chip-Seq_ESCs_Mouse1.11372955
124TP53_23651856_ChIP-Seq_MEFs_Mouse1.11188763
125SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11146184
126CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10995799
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10874978
128EZH2_27304074_Chip-Seq_ESCs_Mouse1.10725121
129SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10463867
130KDM2B_26808549_Chip-Seq_REH_Human1.10165424
131BCAT_22108803_ChIP-Seq_LS180_Human1.09715805
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.09059778
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08977106
134STAT3_18555785_Chip-Seq_ESCs_Mouse1.08316787
135NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07381460
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07267092
137NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07267092
138REST_18959480_ChIP-ChIP_MESCs_Mouse1.06992300
139WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06014371
140RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05886614
141* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05101615
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04134353
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04054960
144SMAD3_21741376_ChIP-Seq_EPCs_Human1.03359288
145JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03313111
146AR_25329375_ChIP-Seq_VCAP_Human1.02807981
147RARB_27405468_Chip-Seq_BRAIN_Mouse1.02758043
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02307984
149RNF2_27304074_Chip-Seq_NSC_Mouse1.02139644
150NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01543061
151SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00514786
152E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99669026
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99533588
154TP53_18474530_ChIP-ChIP_U2OS_Human0.99362273
155FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99290085
156SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99162367
157PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99147346
158TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99096131
159* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98861108
160JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98744824
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98701209
162SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98686171
163CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98233633
164OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98229975
165PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98223576
166ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98157864
167STAT3_23295773_ChIP-Seq_U87_Human0.97968758
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97951954
169UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97944363
170TCF4_23295773_ChIP-Seq_U87_Human0.97633218
171CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96804212
172ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96320123
173CREB1_26743006_Chip-Seq_LNCaP_Human0.96179438
174RUNX1_27514584_Chip-Seq_MCF-7_Human0.94555872
175GATA2_21666600_ChIP-Seq_HMVEC_Human0.94119607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration5.61396937
2MP0000751_myopathy5.61101433
3MP0000733_abnormal_muscle_development5.28329533
4MP0000750_abnormal_muscle_regeneration5.23774291
5MP0004145_abnormal_muscle_electrophysio4.62299726
6MP0004270_analgesia4.55588692
7MP0000747_muscle_weakness3.90908846
8MP0003646_muscle_fatigue3.61302047
9MP0002106_abnormal_muscle_physiology3.32754214
10MP0000759_abnormal_skeletal_muscle3.29699710
11MP0010030_abnormal_orbit_morphology3.09743008
12MP0004087_abnormal_muscle_fiber2.97386665
13MP0005369_muscle_phenotype2.80376263
14MP0002269_muscular_atrophy2.73808578
15MP0008438_abnormal_cutaneous_collagen2.67481267
16MP0004233_abnormal_muscle_weight2.58949319
17MP0005623_abnormal_meninges_morphology2.46354069
18MP0002108_abnormal_muscle_morphology2.41076597
19MP0001542_abnormal_bone_strength2.37115459
20MP0002877_abnormal_melanocyte_morpholog2.31158373
21MP0001299_abnormal_eye_distance/2.26369121
22MP0002837_dystrophic_cardiac_calcinosis2.09630763
23MP0003950_abnormal_plasma_membrane1.96694775
24MP0002734_abnormal_mechanical_nocicepti1.83769062
25MP0003705_abnormal_hypodermis_morpholog1.82270710
26MP0002163_abnormal_gland_morphology1.77208656
27MP0005503_abnormal_tendon_morphology1.65734118
28MP0009780_abnormal_chondrocyte_physiolo1.55323053
29MP0002249_abnormal_larynx_morphology1.54971011
30MP0002234_abnormal_pharynx_morphology1.54470797
31MP0004130_abnormal_muscle_cell1.50317270
32MP0004084_abnormal_cardiac_muscle1.50204095
33MP0003091_abnormal_cell_migration1.39995280
34MP0002971_abnormal_brown_adipose1.39126964
35MP0003279_aneurysm1.33891716
36MP0000767_abnormal_smooth_muscle1.32324072
37MP0004484_altered_response_of1.31829499
38MP0004036_abnormal_muscle_relaxation1.31389966
39MP0005330_cardiomyopathy1.27792743
40MP0005620_abnormal_muscle_contractility1.27464815
41MP0001986_abnormal_taste_sensitivity1.26634628
42MP0004215_abnormal_myocardial_fiber1.21098079
43MP0005275_abnormal_skin_tensile1.13739930
44MP0005423_abnormal_somatic_nervous1.11554433
45MP0002184_abnormal_innervation1.11494294
46MP0004142_abnormal_muscle_tone1.07724315
47MP0006276_abnormal_autonomic_nervous1.06806758
48MP0002114_abnormal_axial_skeleton1.01449891
49MP0002272_abnormal_nervous_system0.99243173
50MP0010630_abnormal_cardiac_muscle0.99216925
51MP0008569_lethality_at_weaning0.98297841
52MP0003566_abnormal_cell_adhesion0.98218312
53MP0009745_abnormal_behavioral_response0.97301800
54MP0001486_abnormal_startle_reflex0.95011724
55MP0002932_abnormal_joint_morphology0.92627104
56MP0009250_abnormal_appendicular_skeleto0.91508355
57MP0001440_abnormal_grooming_behavior0.90870844
58MP0001968_abnormal_touch/_nociception0.89745926
59MP0003385_abnormal_body_wall0.89573547
60MP0004272_abnormal_basement_membrane0.86932535
61MP0004510_myositis0.85455845
62MP0005508_abnormal_skeleton_morphology0.83498136
63MP0002896_abnormal_bone_mineralization0.83196370
64MP0003011_delayed_dark_adaptation0.82089984
65MP0008872_abnormal_physiological_respon0.81558576
66MP0003942_abnormal_urinary_system0.80952866
67MP0000372_irregular_coat_pigmentation0.80694402
68MP0001661_extended_life_span0.80137788
69MP0002972_abnormal_cardiac_muscle0.79761123
70MP0003755_abnormal_palate_morphology0.79538750
71MP0002089_abnormal_postnatal_growth/wei0.78776544
72MP0008775_abnormal_heart_ventricle0.77755918
73MP0002067_abnormal_sensory_capabilities0.77682563
74MP0003879_abnormal_hair_cell0.77604806
75MP0000428_abnormal_craniofacial_morphol0.77482714
76MP0000534_abnormal_ureter_morphology0.77239743
77MP0002127_abnormal_cardiovascular_syste0.76036482
78MP0001346_abnormal_lacrimal_gland0.75045252
79MP0002735_abnormal_chemical_nociception0.74951321
80MP0000955_abnormal_spinal_cord0.73889532
81MP0005076_abnormal_cell_differentiation0.73077681
82MP0002572_abnormal_emotion/affect_behav0.72568060
83MP0002733_abnormal_thermal_nociception0.72119088
84MP0001544_abnormal_cardiovascular_syste0.71102540
85MP0005385_cardiovascular_system_phenoty0.71102540
86MP0004085_abnormal_heartbeat0.70707908
87MP0003137_abnormal_impulse_conducting0.70163563
88MP0005379_endocrine/exocrine_gland_phen0.70079815
89MP0002736_abnormal_nociception_after0.69683701
90MP0008877_abnormal_DNA_methylation0.69296840
91MP0003045_fibrosis0.69075133
92MP0002063_abnormal_learning/memory/cond0.68254197
93MP0001943_abnormal_respiration0.66977462
94MP0004147_increased_porphyrin_level0.66397877
95MP0002064_seizures0.65184662
96MP0001970_abnormal_pain_threshold0.65007697
97MP0004197_abnormal_fetal_growth/weight/0.64521149
98MP0001348_abnormal_lacrimal_gland0.64137025
99MP0005551_abnormal_eye_electrophysiolog0.63747813
100MP0003115_abnormal_respiratory_system0.63510550
101MP0003122_maternal_imprinting0.63247176
102MP0004043_abnormal_pH_regulation0.62923872
103MP0002060_abnormal_skin_morphology0.62904249
104MP0004133_heterotaxia0.61299814
105MP0005645_abnormal_hypothalamus_physiol0.60893024
106MP0001958_emphysema0.60644076
107MP0001501_abnormal_sleep_pattern0.60437669
108MP0002233_abnormal_nose_morphology0.60113860
109MP0003880_abnormal_central_pattern0.59817720
110MP0000762_abnormal_tongue_morphology0.59103420
111MP0004885_abnormal_endolymph0.58918035
112MP0004859_abnormal_synaptic_plasticity0.58297326
113MP0003635_abnormal_synaptic_transmissio0.58155811
114MP0002876_abnormal_thyroid_physiology0.57954985
115MP0002752_abnormal_somatic_nervous0.57343503
116MP0004134_abnormal_chest_morphology0.57297001
117MP0001905_abnormal_dopamine_level0.57082245
118MP0002066_abnormal_motor_capabilities/c0.57059552
119MP0005023_abnormal_wound_healing0.56830574
120MP0001485_abnormal_pinna_reflex0.55960608
121MP0000013_abnormal_adipose_tissue0.55655080
122MP0003959_abnormal_lean_body0.55066731
123MP0006138_congestive_heart_failure0.54776148
124MP0008789_abnormal_olfactory_epithelium0.54487191
125MP0004858_abnormal_nervous_system0.53662503
126MP0001849_ear_inflammation0.51990780
127MP0000003_abnormal_adipose_tissue0.50496068
128MP0002168_other_aberrant_phenotype0.50404016
129MP0002081_perinatal_lethality0.49654493
130MP0002128_abnormal_blood_circulation0.49236911
131MP0003283_abnormal_digestive_organ0.49020421
132MP0001915_intracranial_hemorrhage0.48061361
133MP0000858_altered_metastatic_potential0.47318720
134MP0003935_abnormal_craniofacial_develop0.46762389
135MP0002332_abnormal_exercise_endurance0.45852178
136MP0000163_abnormal_cartilage_morphology0.44326915
137MP0010352_gastrointestinal_tract_polyps0.43477353
138MP0005197_abnormal_uvea_morphology0.43107819
139MP0000432_abnormal_head_morphology0.42954440
140MP0003948_abnormal_gas_homeostasis0.42197592
141MP0005248_abnormal_Harderian_gland0.39856262
142MP0002933_joint_inflammation0.39349737
143MP0009384_cardiac_valve_regurgitation0.39141405
144MP0005621_abnormal_cell_physiology0.38283487
145MP0000266_abnormal_heart_morphology0.37294577
146MP0009046_muscle_twitch0.37163450

Predicted human phenotypes

RankGene SetZ-score
1Popliteal pterygium (HP:0009756)8.10906847
2Fetal akinesia sequence (HP:0001989)8.01776337
3Abnormality of placental membranes (HP:0011409)7.09403786
4Amniotic constriction ring (HP:0009775)7.09403786
5Aplasia of the musculature (HP:0100854)6.80825086
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.62534281
7Type 2 muscle fiber atrophy (HP:0003554)6.60729228
8Malignant hyperthermia (HP:0002047)6.28596740
9Muscle fiber inclusion bodies (HP:0100299)6.16023938
10Muscle fiber atrophy (HP:0100295)5.98423254
11Fatigable weakness (HP:0003473)5.86120326
12Abnormality of the neuromuscular junction (HP:0003398)5.86120326
13Akinesia (HP:0002304)5.69756021
14Nemaline bodies (HP:0003798)5.35614179
15Distal arthrogryposis (HP:0005684)5.05818991
16Type 1 muscle fiber predominance (HP:0003803)5.00151776
17Weak cry (HP:0001612)4.96769143
18Difficulty climbing stairs (HP:0003551)4.82733865
19Round ear (HP:0100830)4.79298670
20Thin ribs (HP:0000883)4.54908426
21Ulnar deviation of the wrist (HP:0003049)4.50480096
22Gowers sign (HP:0003391)4.45757219
23Pterygium (HP:0001059)4.30996285
24Muscle fiber splitting (HP:0003555)4.09217074
25Difficulty running (HP:0009046)4.08743615
26Aplasia/Hypoplasia involving the musculature (HP:0001460)4.01687850
27Calcaneovalgus deformity (HP:0001848)3.98847310
28Mildly elevated creatine phosphokinase (HP:0008180)3.96055585
29Easy fatigability (HP:0003388)3.94788213
30Distal lower limb amyotrophy (HP:0008944)3.86753256
31Abnormality of the calf musculature (HP:0001430)3.84745710
32Bulbar palsy (HP:0001283)3.75575046
33Hypoplastic heart (HP:0001961)3.60571727
34Deformed tarsal bones (HP:0008119)3.56861187
35Exercise-induced muscle cramps (HP:0003710)3.56511376
36Cystic hygroma (HP:0000476)3.52837665
37Myopathic facies (HP:0002058)3.50538832
38Absent phalangeal crease (HP:0006109)3.49241478
39Increased connective tissue (HP:0009025)3.27945144
40EMG: myopathic abnormalities (HP:0003458)3.23760528
41Abnormality of skeletal muscle fiber size (HP:0012084)3.21927282
42Lower limb amyotrophy (HP:0007210)3.06846674
43Calf muscle hypertrophy (HP:0008981)3.04862716
44Abnormalities of placenta or umbilical cord (HP:0001194)2.97171824
45Generalized muscle weakness (HP:0003324)2.92146007
46Abnormal finger flexion creases (HP:0006143)2.91521037
47Increased variability in muscle fiber diameter (HP:0003557)2.90247898
48Hip contracture (HP:0003273)2.89394654
49Sudden death (HP:0001699)2.84941568
50Muscle hypertrophy of the lower extremities (HP:0008968)2.80844448
51Trismus (HP:0000211)2.71181726
52Diminished movement (HP:0002374)2.70171643
53Respiratory insufficiency due to muscle weakness (HP:0002747)2.64663491
54Hyporeflexia of lower limbs (HP:0002600)2.63659223
55Abnormality of the calcaneus (HP:0008364)2.61944224
56Scapular winging (HP:0003691)2.57014056
57Depressed nasal tip (HP:0000437)2.54556961
58Spinal rigidity (HP:0003306)2.48714193
59Poor suck (HP:0002033)2.46472986
60Chin dimple (HP:0010751)2.38529545
61Long clavicles (HP:0000890)2.38009141
62Nonprogressive disorder (HP:0003680)2.36409799
63Breech presentation (HP:0001623)2.34872378
64Upper limb amyotrophy (HP:0009129)2.32980372
65Distal upper limb amyotrophy (HP:0007149)2.32980372
66Neonatal respiratory distress (HP:0002643)2.32914853
67Webbed neck (HP:0000465)2.32692329
68Neck muscle weakness (HP:0000467)2.31811853
69Limb-girdle muscle atrophy (HP:0003797)2.31508617
70Shoulder girdle muscle weakness (HP:0003547)2.27662219
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.27575700
72Pelvic girdle muscle weakness (HP:0003749)2.26587456
73Abnormality of the musculature of the pelvis (HP:0001469)2.24444612
74Abnormality of the hip-girdle musculature (HP:0001445)2.24444612
75Slender build (HP:0001533)2.24037994
76Premature rupture of membranes (HP:0001788)2.22851748
77Arthrogryposis multiplex congenita (HP:0002804)2.21551748
78Abnormality of the left ventricular outflow tract (HP:0011103)2.11698266
79Subaortic stenosis (HP:0001682)2.11698266
80Increased density of long bones (HP:0006392)2.09569052
81Limited hip movement (HP:0008800)2.05750225
82Bundle branch block (HP:0011710)2.04472715
83Exercise-induced myalgia (HP:0003738)1.95419381
84Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.91467701
85Limb-girdle muscle weakness (HP:0003325)1.91080663
86Mask-like facies (HP:0000298)1.88338149
87Asymmetric septal hypertrophy (HP:0001670)1.86733010
88Vertebral fusion (HP:0002948)1.86441255
89Infantile muscular hypotonia (HP:0008947)1.86160518
90Abnormality of the shoulder girdle musculature (HP:0001435)1.85888364
91Short palpebral fissure (HP:0012745)1.80108448
92Areflexia of lower limbs (HP:0002522)1.79959176
93Myoglobinuria (HP:0002913)1.79414848
94Knee flexion contracture (HP:0006380)1.77833820
95Myotonia (HP:0002486)1.77534666
96Metatarsus adductus (HP:0001840)1.77349461
97Protrusio acetabuli (HP:0003179)1.76940152
98Muscle stiffness (HP:0003552)1.73964313
99Ankle contracture (HP:0006466)1.71442155
100Rimmed vacuoles (HP:0003805)1.69510967
101EMG: neuropathic changes (HP:0003445)1.69126140
102Frequent falls (HP:0002359)1.68879225
103Anterior segment dysgenesis (HP:0007700)1.65844167
104Rib fusion (HP:0000902)1.63720183
105Adducted thumb (HP:0001181)1.62050712
106Distal lower limb muscle weakness (HP:0009053)1.61757550
107Lipoatrophy (HP:0100578)1.59809403
108Facial diplegia (HP:0001349)1.58730719
109Generalized amyotrophy (HP:0003700)1.58057846
110Waddling gait (HP:0002515)1.56792072
111Rocker bottom foot (HP:0001838)1.56032575
112Short thorax (HP:0010306)1.56023634
113Decreased muscle mass (HP:0003199)1.55082467
114Muscular dystrophy (HP:0003560)1.54400746
115Prolonged QT interval (HP:0001657)1.53644895
116Nasal speech (HP:0001611)1.53272450
117Symphalangism affecting the phalanges of the hand (HP:0009773)1.51877019
118Ulnar deviation of finger (HP:0009465)1.51851812
119Hypoplastic ischia (HP:0003175)1.51630842
120Joint contractures involving the joints of the feet (HP:0100492)1.51511539
121Rhabdomyolysis (HP:0003201)1.50813866
122Tarsal synostosis (HP:0008368)1.48153317
123Heart block (HP:0012722)1.46250095
124Left ventricular hypertrophy (HP:0001712)1.42074797
125Fused cervical vertebrae (HP:0002949)1.40343404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK7.56520484
2MOS7.43766193
3TRIB34.37791984
4PIK3CG3.64136562
5PINK12.94685866
6FGFR42.67469239
7OBSCN2.51872877
8TTN2.49308281
9PIM22.20264940
10MARK12.04430681
11RIPK12.02332176
12EPHB11.99365587
13CDK151.93082914
14MAP2K11.92194052
15CDK181.87117710
16CDK141.82740135
17FRK1.80595633
18MAP3K101.79394273
19CDK11A1.78284640
20ILK1.76462162
21PAK41.64821041
22PKN21.60304024
23EEF2K1.45328785
24ROCK21.40249039
25ADRBK21.35519180
26DDR21.34984135
27CDK61.30258999
28CCNB11.26100440
29MAPK131.23015545
30MAPKAPK31.20234333
31NME11.19766615
32SIK11.11589314
33PDGFRA1.08703573
34MAP4K21.03361858
35PTK61.02552598
36GRK10.96695968
37AKT20.94579162
38MTOR0.94405552
39TRPM70.91556786
40BMX0.90308729
41PTK20.90297672
42PAK60.88078317
43WNK40.87779471
44BCKDK0.83606823
45MAPK120.81541243
46CAMKK20.80683882
47EPHA30.79867242
48FER0.78876676
49INSRR0.77594522
50MARK20.76553909
51LRRK20.76472273
52ROCK10.73618374
53ICK0.72478016
54TLK10.72404692
55LATS10.70736520
56ERBB30.68925925
57TIE10.68632978
58PRKCG0.68476987
59ALK0.66145552
60DYRK1B0.64915714
61LIMK10.64249898
62PLK20.63896458
63CAMKK10.63467488
64PAK20.61310937
65LATS20.60689600
66ZAK0.60136431
67PIK3CA0.59696699
68MAPK110.59569751
69PHKG10.58412228
70PHKG20.58412228
71TYRO30.58229830
72NTRK30.57511184
73PNCK0.56307865
74MAP2K60.56033177
75WNK30.55072959
76MAP3K70.52812234
77FGFR10.52351186
78CDK50.51377237
79OXSR10.49815116
80CASK0.49476959
81KSR10.49144632
82BMPR1B0.48738897
83RPS6KB20.48681988
84TNIK0.47737455
85MAP2K30.43935952
86DYRK20.43919729
87EPHB20.43578588
88CAMK10.43458880
89RET0.43232100
90EPHA40.43027037
91MAPKAPK50.41922883
92PRKACA0.41419897
93PKN10.41363502
94STK390.40395909
95CSNK1G20.39127571
96CAMK2B0.38433054
97MAP2K20.38205940
98CAMK2A0.37088286
99DMPK0.36710223
100PTK2B0.36287888
101ADRBK10.36183276
102CAMK2G0.35260935
103NEK90.35157476
104MAP3K50.34707783
105RPS6KA30.34538111
106CDK190.33321596
107ABL10.32937931
108PRKAA10.32829497
109PAK30.32571224
110MAPK100.32286031
111PRKCE0.32091400
112FGFR20.31655110
113HIPK20.31384156
114PRKACB0.31257478
115CDK120.31182344
116PRKD30.30876879
117CAMK2D0.30120869
118PDGFRB0.29907120
119PAK10.29117067
120PRKG10.28904376
121EPHA20.28461346
122NEK10.28311803
123PRKCA0.28005731
124WNK10.27546290
125CSNK1D0.27124283
126INSR0.27022831
127MAPK150.26814473
128FGFR30.26047972
129NUAK10.25620957
130SGK2230.24524394
131SGK4940.24524394
132CAMK40.23990942
133DAPK30.23495069
134TAOK30.23435127
135PRKCH0.23310910
136MAPK90.23053609
137MINK10.22880473
138ABL20.22215363
139TGFBR10.21965911
140MAPKAPK20.21376027
141MAPK70.21321149
142MAP2K40.20941516
143PRKAA20.19862912
144CSNK1G10.19705954
145MAP3K90.19031900
146SGK20.18716088
147DAPK20.18702180
148MAPK80.18688112
149CDK80.18533875
150CDK90.18344715
151PDPK10.18204177
152NTRK10.18037439
153NTRK20.17751945
154SRC0.17682809
155ERN10.17637815
156PDK40.17499952
157PDK30.17499952

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054144.16596425
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.10063012
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054124.06780009
4Phototransduction_Homo sapiens_hsa047442.30735539
5Focal adhesion_Homo sapiens_hsa045102.22282117
6Proteoglycans in cancer_Homo sapiens_hsa052052.10634520
7ECM-receptor interaction_Homo sapiens_hsa045121.96884908
8Nitrogen metabolism_Homo sapiens_hsa009101.91510535
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.86937363
10Cardiac muscle contraction_Homo sapiens_hsa042601.82164279
11Oxytocin signaling pathway_Homo sapiens_hsa049211.75281444
12Tight junction_Homo sapiens_hsa045301.72128520
13Viral myocarditis_Homo sapiens_hsa054161.71730120
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66564501
15Arginine and proline metabolism_Homo sapiens_hsa003301.64329175
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63444744
17Dorso-ventral axis formation_Homo sapiens_hsa043201.63299141
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58719563
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51376234
20Parkinsons disease_Homo sapiens_hsa050121.45936635
21Chronic myeloid leukemia_Homo sapiens_hsa052201.44753965
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43873490
23Alzheimers disease_Homo sapiens_hsa050101.42526245
24Oxidative phosphorylation_Homo sapiens_hsa001901.41917570
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41693928
26Amoebiasis_Homo sapiens_hsa051461.38842152
27Butanoate metabolism_Homo sapiens_hsa006501.35527698
28Gap junction_Homo sapiens_hsa045401.33554805
29Glioma_Homo sapiens_hsa052141.32391423
30Linoleic acid metabolism_Homo sapiens_hsa005911.30759647
31Long-term depression_Homo sapiens_hsa047301.24297559
32Estrogen signaling pathway_Homo sapiens_hsa049151.21268800
33GnRH signaling pathway_Homo sapiens_hsa049121.21126648
34Circadian entrainment_Homo sapiens_hsa047131.20165239
35MAPK signaling pathway_Homo sapiens_hsa040101.19722209
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18992631
37Morphine addiction_Homo sapiens_hsa050321.18904983
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17257923
39Long-term potentiation_Homo sapiens_hsa047201.13650672
40Adherens junction_Homo sapiens_hsa045201.12342014
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11706071
42Insulin signaling pathway_Homo sapiens_hsa049101.10809739
43Cholinergic synapse_Homo sapiens_hsa047251.09752041
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09449338
45Axon guidance_Homo sapiens_hsa043601.08570079
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.06523193
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06037174
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03819788
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03597477
50Glucagon signaling pathway_Homo sapiens_hsa049221.03065331
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02273068
52Bladder cancer_Homo sapiens_hsa052191.01294711
53Notch signaling pathway_Homo sapiens_hsa043301.01263719
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00660605
55Salivary secretion_Homo sapiens_hsa049701.00324018
56Salmonella infection_Homo sapiens_hsa051321.00154316
57Platelet activation_Homo sapiens_hsa046111.00074976
58mTOR signaling pathway_Homo sapiens_hsa041500.99890465
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99545373
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.98543810
61Olfactory transduction_Homo sapiens_hsa047400.97481894
62Melanoma_Homo sapiens_hsa052180.96818814
63Propanoate metabolism_Homo sapiens_hsa006400.96490587
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96075558
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95099034
66Gastric acid secretion_Homo sapiens_hsa049710.94846230
67Melanogenesis_Homo sapiens_hsa049160.94711736
68Tryptophan metabolism_Homo sapiens_hsa003800.93912582
69Hippo signaling pathway_Homo sapiens_hsa043900.91580435
70MicroRNAs in cancer_Homo sapiens_hsa052060.90482886
71Calcium signaling pathway_Homo sapiens_hsa040200.90371914
72Protein digestion and absorption_Homo sapiens_hsa049740.89754447
73Renal cell carcinoma_Homo sapiens_hsa052110.89047055
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88320119
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88226216
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.88102355
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.87405236
78Insulin secretion_Homo sapiens_hsa049110.85531688
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.84533670
80ErbB signaling pathway_Homo sapiens_hsa040120.83339009
81Hedgehog signaling pathway_Homo sapiens_hsa043400.83324006
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80249542
83FoxO signaling pathway_Homo sapiens_hsa040680.79398834
84Pancreatic cancer_Homo sapiens_hsa052120.78886160
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.78711429
86Prostate cancer_Homo sapiens_hsa052150.78681187
87TGF-beta signaling pathway_Homo sapiens_hsa043500.78431682
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77495611
89VEGF signaling pathway_Homo sapiens_hsa043700.77360381
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.77062027
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.76414420
92HIF-1 signaling pathway_Homo sapiens_hsa040660.76107484
93Acute myeloid leukemia_Homo sapiens_hsa052210.75908274
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75767085
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75501286
96Glutamatergic synapse_Homo sapiens_hsa047240.75242708
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74951959
98Ether lipid metabolism_Homo sapiens_hsa005650.73879063
99Serotonergic synapse_Homo sapiens_hsa047260.72551060
100Nicotine addiction_Homo sapiens_hsa050330.72351889
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71891930
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71627708
103Rap1 signaling pathway_Homo sapiens_hsa040150.71241677
104Renin secretion_Homo sapiens_hsa049240.70994000
105beta-Alanine metabolism_Homo sapiens_hsa004100.70462463
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70260251
107Prion diseases_Homo sapiens_hsa050200.70105355
108Dopaminergic synapse_Homo sapiens_hsa047280.69954334
109GABAergic synapse_Homo sapiens_hsa047270.67771856
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66131821
111Amphetamine addiction_Homo sapiens_hsa050310.65627521
112Thyroid hormone synthesis_Homo sapiens_hsa049180.65285465
113Endometrial cancer_Homo sapiens_hsa052130.64426879
114Sulfur metabolism_Homo sapiens_hsa009200.64360649
115Non-small cell lung cancer_Homo sapiens_hsa052230.63983548
116Endocytosis_Homo sapiens_hsa041440.63620153
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63552784
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63131015
119Synaptic vesicle cycle_Homo sapiens_hsa047210.62185165
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61689096
121Arginine biosynthesis_Homo sapiens_hsa002200.61643995
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61601665
123Circadian rhythm_Homo sapiens_hsa047100.59896403
124Huntingtons disease_Homo sapiens_hsa050160.59851096
125Cocaine addiction_Homo sapiens_hsa050300.59827625
126Histidine metabolism_Homo sapiens_hsa003400.58617960
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58434779
128Peroxisome_Homo sapiens_hsa041460.57720164
129cAMP signaling pathway_Homo sapiens_hsa040240.57470211
130One carbon pool by folate_Homo sapiens_hsa006700.56967065
131Wnt signaling pathway_Homo sapiens_hsa043100.56389077
132AMPK signaling pathway_Homo sapiens_hsa041520.56346058
133Basal cell carcinoma_Homo sapiens_hsa052170.56110797
134Insulin resistance_Homo sapiens_hsa049310.55538786
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55294951
136Selenocompound metabolism_Homo sapiens_hsa004500.54306692
137Ovarian steroidogenesis_Homo sapiens_hsa049130.53198306
138Taste transduction_Homo sapiens_hsa047420.52602404
139Protein export_Homo sapiens_hsa030600.51412892
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51402368
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51281489
142Small cell lung cancer_Homo sapiens_hsa052220.49587932
143Bile secretion_Homo sapiens_hsa049760.46150934
144Regulation of autophagy_Homo sapiens_hsa041400.44958439
145Sulfur relay system_Homo sapiens_hsa041220.43063450
146Mineral absorption_Homo sapiens_hsa049780.42151079
147Fatty acid degradation_Homo sapiens_hsa000710.41811462
148Pyruvate metabolism_Homo sapiens_hsa006200.37988720
149Basal transcription factors_Homo sapiens_hsa030220.37786483
150RNA polymerase_Homo sapiens_hsa030200.35964867
151Pancreatic secretion_Homo sapiens_hsa049720.35531883
152Arachidonic acid metabolism_Homo sapiens_hsa005900.34609051

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