CDH10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.55504937
2axon ensheathment in central nervous system (GO:0032291)5.52403651
3central nervous system myelination (GO:0022010)5.52403651
4presynaptic membrane assembly (GO:0097105)5.47719946
5presynaptic membrane organization (GO:0097090)5.08542536
6L-amino acid import (GO:0043092)4.56356933
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.54665958
8vocalization behavior (GO:0071625)4.51355956
9protein localization to synapse (GO:0035418)4.36578123
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.29757510
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.24845061
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.23452142
13synaptic vesicle exocytosis (GO:0016079)4.15423653
14negative regulation of synaptic transmission, GABAergic (GO:0032229)4.13921442
15neurotransmitter-gated ion channel clustering (GO:0072578)4.10809603
16locomotory exploration behavior (GO:0035641)4.08211852
17transmission of nerve impulse (GO:0019226)4.07199452
18glutamate receptor signaling pathway (GO:0007215)4.06544533
19postsynaptic membrane organization (GO:0001941)4.04052670
20neuronal action potential propagation (GO:0019227)3.99185007
21gamma-aminobutyric acid signaling pathway (GO:0007214)3.93450607
22regulation of glutamate receptor signaling pathway (GO:1900449)3.87009991
23neuron recognition (GO:0008038)3.86727842
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.79956217
25amino acid import (GO:0043090)3.79087457
26pyrimidine nucleobase catabolic process (GO:0006208)3.78175297
27protein polyglutamylation (GO:0018095)3.78101266
28synaptic transmission, glutamatergic (GO:0035249)3.75133285
29righting reflex (GO:0060013)3.72295263
30glutamate secretion (GO:0014047)3.69260944
31regulation of synaptic vesicle exocytosis (GO:2000300)3.68646383
32neuron-neuron synaptic transmission (GO:0007270)3.64782740
33negative regulation of neurotransmitter transport (GO:0051589)3.64379311
34nonmotile primary cilium assembly (GO:0035058)3.60255639
35gamma-aminobutyric acid transport (GO:0015812)3.58664581
36cerebellar granule cell differentiation (GO:0021707)3.52918324
37fatty acid elongation (GO:0030497)3.52684658
38exploration behavior (GO:0035640)3.49282440
39positive regulation of synapse assembly (GO:0051965)3.48995341
40nucleobase catabolic process (GO:0046113)3.47939838
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47136050
42long-chain fatty acid biosynthetic process (GO:0042759)3.45429479
43response to pheromone (GO:0019236)3.44338116
44axonal fasciculation (GO:0007413)3.43193443
45dendritic spine morphogenesis (GO:0060997)3.42219002
46startle response (GO:0001964)3.37035657
47myelination (GO:0042552)3.35144831
48neurotransmitter uptake (GO:0001504)3.33271502
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32854048
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.32833827
51negative regulation of neurotransmitter secretion (GO:0046929)3.29530420
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.29053992
53cerebral cortex radially oriented cell migration (GO:0021799)3.28726412
54long-term synaptic potentiation (GO:0060291)3.28045841
55negative regulation of cytosolic calcium ion concentration (GO:0051481)3.28020402
56axon ensheathment (GO:0008366)3.26489871
57ensheathment of neurons (GO:0007272)3.26489871
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26025630
59synaptic vesicle maturation (GO:0016188)3.24384003
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.23928188
61calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.20810037
62auditory behavior (GO:0031223)3.20357584
63glycosphingolipid biosynthetic process (GO:0006688)3.20284925
64neuron fate determination (GO:0048664)3.19589421
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16490975
66regulation of synaptic vesicle transport (GO:1902803)3.15962540
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15161560
68adult walking behavior (GO:0007628)3.13670934
69regulation of long-term neuronal synaptic plasticity (GO:0048169)3.13020287
70regulation of postsynaptic membrane potential (GO:0060078)3.12296313
71mechanosensory behavior (GO:0007638)3.12254112
72regulation of neuronal synaptic plasticity (GO:0048168)3.12043199
73C4-dicarboxylate transport (GO:0015740)3.05945958
74retinal ganglion cell axon guidance (GO:0031290)3.05608057
75dendrite morphogenesis (GO:0048813)3.04739221
76positive regulation of membrane potential (GO:0045838)3.03602413
77response to histamine (GO:0034776)3.02036163
78cellular potassium ion homeostasis (GO:0030007)3.01940057
79intraciliary transport (GO:0042073)2.99212283
80neuronal ion channel clustering (GO:0045161)2.98632622
81regulation of respiratory system process (GO:0044065)2.97883548
82proline transport (GO:0015824)2.97753006
83long-term memory (GO:0007616)2.97645355
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97362908
85neurotransmitter secretion (GO:0007269)2.95019163
86regulation of dendritic spine morphogenesis (GO:0061001)2.93952666
87response to auditory stimulus (GO:0010996)2.93677794
88synaptic vesicle docking involved in exocytosis (GO:0016081)2.93424464
89reflex (GO:0060004)2.92388498
90glycerophospholipid catabolic process (GO:0046475)2.91304697
91synapse assembly (GO:0007416)2.90677063
92membrane hyperpolarization (GO:0060081)2.89608713
93regulation of synaptic plasticity (GO:0048167)2.88751287
94regulation of dendritic spine development (GO:0060998)2.87467792
95learning (GO:0007612)2.85383570
96layer formation in cerebral cortex (GO:0021819)2.83014384
97membrane assembly (GO:0071709)2.82956142
98regulation of synapse assembly (GO:0051963)2.82688969
99neurotransmitter transport (GO:0006836)2.79615613
100detection of calcium ion (GO:0005513)2.79329267
101regulation of neurotransmitter secretion (GO:0046928)2.78206211
102regulation of neurotransmitter uptake (GO:0051580)2.78160793
103behavioral response to nicotine (GO:0035095)2.77702461
104neuronal action potential (GO:0019228)2.76936849
105central nervous system projection neuron axonogenesis (GO:0021952)2.76172748
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74937095
107regulation of vesicle fusion (GO:0031338)2.74295873
108synaptic vesicle endocytosis (GO:0048488)2.73976425
109negative regulation of synaptic transmission (GO:0050805)2.73785643
110positive regulation of action potential (GO:0045760)2.72017835
111dendrite development (GO:0016358)2.71878950
112neuromuscular synaptic transmission (GO:0007274)2.71331956
113negative regulation of protein localization to cell surface (GO:2000009)2.71230236
114regulation of synapse structural plasticity (GO:0051823)2.71211411
115regulation of voltage-gated calcium channel activity (GO:1901385)2.71035865
116oligodendrocyte differentiation (GO:0048709)2.70943726
117synapse organization (GO:0050808)2.70321037
118regulation of neurotransmitter levels (GO:0001505)2.70232390
119regulation of calcium ion-dependent exocytosis (GO:0017158)2.70064235
120regulation of glutamate secretion (GO:0014048)2.68800925
121positive regulation of dendritic spine development (GO:0060999)2.68455824
122establishment of mitochondrion localization (GO:0051654)2.67895890
123regulation of synaptic transmission, GABAergic (GO:0032228)2.67513787
124regulation of respiratory gaseous exchange (GO:0043576)2.65689684
125inner ear receptor stereocilium organization (GO:0060122)2.62961722
126epithelial cilium movement (GO:0003351)2.62205712
127dendritic spine organization (GO:0097061)2.62042381
128negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.60389962
129protein localization to cilium (GO:0061512)2.60228983
130respiratory chain complex IV assembly (GO:0008535)2.56962345
131central nervous system neuron axonogenesis (GO:0021955)2.56095369
132membrane depolarization during action potential (GO:0086010)2.55841427
133epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.55750420
134inositol phosphate catabolic process (GO:0071545)2.54919486
135cochlea development (GO:0090102)2.52301104
136retinal cone cell development (GO:0046549)2.51832989
137platelet dense granule organization (GO:0060155)2.50437552
138cilium organization (GO:0044782)2.49101606
139neuromuscular process controlling posture (GO:0050884)2.46796026
140* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.46789490
141cilium assembly (GO:0042384)2.46603870
142adult behavior (GO:0030534)2.45018126
143regulation of cilium movement (GO:0003352)2.43426151
144phosphorylated carbohydrate dephosphorylation (GO:0046838)2.42507965
145inositol phosphate dephosphorylation (GO:0046855)2.42507965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75132839
2GBX2_23144817_ChIP-Seq_PC3_Human4.27209646
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95822802
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89448177
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85160703
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50649787
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48053885
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.47945121
9TAF15_26573619_Chip-Seq_HEK293_Human2.42753313
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.42630822
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41367829
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41367829
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38789958
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33324401
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29167297
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22470764
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17104009
18AR_21572438_ChIP-Seq_LNCaP_Human2.11587261
19* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10452640
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07495087
21REST_21632747_ChIP-Seq_MESCs_Mouse2.06593348
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.02628643
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.00730294
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99653003
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99650301
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88116997
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86022377
28* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83124659
29DROSHA_22980978_ChIP-Seq_HELA_Human1.82874842
30* CBX2_27304074_Chip-Seq_ESCs_Mouse1.80885844
31* P300_19829295_ChIP-Seq_ESCs_Human1.78374929
32* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72113456
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71105962
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.67949389
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67897418
36* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67321319
37SMAD4_21799915_ChIP-Seq_A2780_Human1.66893176
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66119690
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.64862407
40FUS_26573619_Chip-Seq_HEK293_Human1.64293246
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63215605
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63068081
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62774164
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.59979939
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.57337971
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53897706
47VDR_22108803_ChIP-Seq_LS180_Human1.53896581
48* RARB_27405468_Chip-Seq_BRAIN_Mouse1.51878681
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47708976
50ER_23166858_ChIP-Seq_MCF-7_Human1.46984736
51IGF1R_20145208_ChIP-Seq_DFB_Human1.43185693
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42558483
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40769979
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40295879
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.36629230
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35921359
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33947123
58* RNF2_27304074_Chip-Seq_NSC_Mouse1.33074302
59AR_25329375_ChIP-Seq_VCAP_Human1.31462555
60* STAT3_23295773_ChIP-Seq_U87_Human1.30461287
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27050036
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26772471
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.26001168
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24839561
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24478162
66BCAT_22108803_ChIP-Seq_LS180_Human1.24259397
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24072464
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19563717
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18324535
70TP53_18474530_ChIP-ChIP_U2OS_Human1.17618185
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16805593
72* TCF4_23295773_ChIP-Seq_U87_Human1.16461403
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16076305
74ZNF274_21170338_ChIP-Seq_K562_Hela1.15792536
75* TAL1_26923725_Chip-Seq_HPCs_Mouse1.14721468
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13814217
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13781369
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12558893
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12468142
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12223420
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12223420
82RUNX2_22187159_ChIP-Seq_PCA_Human1.11978333
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.11679229
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11549699
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11446583
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.11094395
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.10506128
88TP53_16413492_ChIP-PET_HCT116_Human1.09753386
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.09705286
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.07919553
91CBP_20019798_ChIP-Seq_JUKART_Human1.06787141
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06787141
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06507609
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05248807
95P53_22387025_ChIP-Seq_ESCs_Mouse1.05194347
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04880103
97* TCF4_22108803_ChIP-Seq_LS180_Human1.04806380
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04363789
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03773939
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03442290
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03049061
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02336980
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02330366
104* JUN_21703547_ChIP-Seq_K562_Human1.02147142
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01505417
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.01420419
107TP53_22573176_ChIP-Seq_HFKS_Human1.00819624
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99536145
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99281159
110AHR_22903824_ChIP-Seq_MCF-7_Human0.99176408
111* SOX9_26525672_Chip-Seq_HEART_Mouse0.98943934
112IRF1_19129219_ChIP-ChIP_H3396_Human0.98704532
113EWS_26573619_Chip-Seq_HEK293_Human0.98635334
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97857742
115RING1B_27294783_Chip-Seq_NPCs_Mouse0.96540437
116* AR_19668381_ChIP-Seq_PC3_Human0.96060423
117KDM2B_26808549_Chip-Seq_REH_Human0.95828983
118P300_18555785_Chip-Seq_ESCs_Mouse0.95578521
119* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95038034
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94408029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.27945632
2MP0004859_abnormal_synaptic_plasticity4.60277738
3MP0004270_analgesia3.61046498
4MP0003635_abnormal_synaptic_transmissio3.42227607
5MP0009745_abnormal_behavioral_response3.11735600
6MP0002064_seizures3.01515732
7MP0005423_abnormal_somatic_nervous2.94623058
8MP0001486_abnormal_startle_reflex2.91316289
9MP0009046_muscle_twitch2.81742036
10MP0002063_abnormal_learning/memory/cond2.80784378
11MP0002572_abnormal_emotion/affect_behav2.70170734
12MP0001968_abnormal_touch/_nociception2.66458390
13MP0002272_abnormal_nervous_system2.64578648
14MP0002734_abnormal_mechanical_nocicepti2.38568170
15MP0001529_abnormal_vocalization2.34273709
16MP0002736_abnormal_nociception_after2.30514636
17MP0000778_abnormal_nervous_system2.28772818
18MP0004885_abnormal_endolymph2.27367962
19MP0001440_abnormal_grooming_behavior2.25224328
20MP0000920_abnormal_myelination2.15280937
21MP0003329_amyloid_beta_deposits2.14235794
22MP0002735_abnormal_chemical_nociception2.08226640
23MP0001501_abnormal_sleep_pattern2.08209747
24MP0002067_abnormal_sensory_capabilities2.02892457
25MP0001905_abnormal_dopamine_level1.98095633
26MP0004142_abnormal_muscle_tone1.84981203
27MP0003690_abnormal_glial_cell1.81948266
28MP0003136_yellow_coat_color1.79049397
29MP0005171_absent_coat_pigmentation1.78475308
30MP0002733_abnormal_thermal_nociception1.75259478
31MP0004742_abnormal_vestibular_system1.74838298
32MP0005646_abnormal_pituitary_gland1.72596207
33MP0006276_abnormal_autonomic_nervous1.69881535
34MP0004924_abnormal_behavior1.68796806
35MP0005386_behavior/neurological_phenoty1.68796806
36MP0001970_abnormal_pain_threshold1.67528217
37MP0002557_abnormal_social/conspecific_i1.65096168
38MP0002184_abnormal_innervation1.63536677
39MP0005248_abnormal_Harderian_gland1.56594200
40MP0002837_dystrophic_cardiac_calcinosis1.55802035
41MP0001485_abnormal_pinna_reflex1.55186323
42MP0009780_abnormal_chondrocyte_physiolo1.53560031
43MP0003121_genomic_imprinting1.53221693
44MP0002882_abnormal_neuron_morphology1.49753254
45MP0008569_lethality_at_weaning1.49010490
46MP0000955_abnormal_spinal_cord1.48266539
47MP0001502_abnormal_circadian_rhythm1.45946342
48MP0001188_hyperpigmentation1.44525916
49MP0003634_abnormal_glial_cell1.43041111
50MP0008877_abnormal_DNA_methylation1.42941911
51MP0005551_abnormal_eye_electrophysiolog1.42069397
52MP0005409_darkened_coat_color1.41833278
53MP0005645_abnormal_hypothalamus_physiol1.41458764
54MP0002066_abnormal_motor_capabilities/c1.41091771
55MP0002909_abnormal_adrenal_gland1.38959226
56MP0001984_abnormal_olfaction1.37010761
57MP0002653_abnormal_ependyma_morphology1.29104958
58MP0001963_abnormal_hearing_physiology1.27069311
59MP0004133_heterotaxia1.26852471
60MP0002822_catalepsy1.26835140
61MP0002229_neurodegeneration1.26587285
62MP0003633_abnormal_nervous_system1.26393506
63MP0003631_nervous_system_phenotype1.23931071
64MP0005187_abnormal_penis_morphology1.21149473
65MP0003632_abnormal_nervous_system1.19288715
66MP0004147_increased_porphyrin_level1.19146415
67MP0004858_abnormal_nervous_system1.14894698
68MP0004811_abnormal_neuron_physiology1.14806163
69MP0002152_abnormal_brain_morphology1.11126853
70MP0000569_abnormal_digit_pigmentation1.10117203
71MP0002752_abnormal_somatic_nervous1.06967187
72MP0000647_abnormal_sebaceous_gland1.05436362
73MP0000427_abnormal_hair_cycle1.03763516
74MP0005499_abnormal_olfactory_system1.03154617
75MP0005394_taste/olfaction_phenotype1.03154617
76MP0008789_abnormal_olfactory_epithelium1.02197913
77MP0000026_abnormal_inner_ear1.01094279
78MP0002751_abnormal_autonomic_nervous0.98024024
79MP0000631_abnormal_neuroendocrine_gland0.97791384
80MP0000604_amyloidosis0.96516350
81MP0000013_abnormal_adipose_tissue0.95271454
82MP0003879_abnormal_hair_cell0.94104858
83MP0003787_abnormal_imprinting0.89222974
84MP0002938_white_spotting0.87760215
85MP0003011_delayed_dark_adaptation0.87592379
86MP0000566_synostosis0.86414756
87MP0003938_abnormal_ear_development0.86335178
88MP0001299_abnormal_eye_distance/0.85681621
89MP0002876_abnormal_thyroid_physiology0.83404362
90MP0005084_abnormal_gallbladder_morpholo0.83310263
91MP0003122_maternal_imprinting0.81833756
92MP0002234_abnormal_pharynx_morphology0.81789427
93MP0003137_abnormal_impulse_conducting0.80487157
94MP0000383_abnormal_hair_follicle0.79934739
95MP0002069_abnormal_eating/drinking_beha0.78231622
96MP0001664_abnormal_digestion0.78209115
97MP0005410_abnormal_fertilization0.77597185
98MP0002928_abnormal_bile_duct0.77536096
99MP0004085_abnormal_heartbeat0.76875337
100MP0005391_vision/eye_phenotype0.75491389
101MP0001177_atelectasis0.74958740
102MP0002163_abnormal_gland_morphology0.74865196
103MP0003950_abnormal_plasma_membrane0.72733494
104MP0002102_abnormal_ear_morphology0.72527433
105MP0004145_abnormal_muscle_electrophysio0.71686205
106MP0005253_abnormal_eye_physiology0.71667991
107MP0002090_abnormal_vision0.67911902
108MP0004134_abnormal_chest_morphology0.64340416
109MP0005195_abnormal_posterior_eye0.64180860
110MP0004215_abnormal_myocardial_fiber0.62918587
111MP0006292_abnormal_olfactory_placode0.61821452
112MP0003861_abnormal_nervous_system0.60000955
113MP0001943_abnormal_respiration0.59275897
114MP0006072_abnormal_retinal_apoptosis0.57816887
115MP0000462_abnormal_digestive_system0.57422609
116MP0008874_decreased_physiological_sensi0.57149217
117MP0010386_abnormal_urinary_bladder0.57126146
118MP0002638_abnormal_pupillary_reflex0.57023438
119MP0003878_abnormal_ear_physiology0.56674507
120MP0005377_hearing/vestibular/ear_phenot0.56674507
121MP0005379_endocrine/exocrine_gland_phen0.55447558
122MP0001986_abnormal_taste_sensitivity0.55354604
123MP0000751_myopathy0.54169174
124MP0005535_abnormal_body_temperature0.53009955
125MP0004043_abnormal_pH_regulation0.49959181

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.13617417
2Epileptic encephalopathy (HP:0200134)5.03329857
3Neurofibrillary tangles (HP:0002185)4.48804221
4Myokymia (HP:0002411)4.35980434
5Focal seizures (HP:0007359)4.30023393
6Hyperventilation (HP:0002883)4.24809718
7Atonic seizures (HP:0010819)4.22601397
8Febrile seizures (HP:0002373)3.99822656
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.82381545
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.82381545
11Cerebral inclusion bodies (HP:0100314)3.64143687
12Broad-based gait (HP:0002136)3.50008927
13Abnormality of the corticospinal tract (HP:0002492)3.48824636
14Supranuclear gaze palsy (HP:0000605)3.47767276
15True hermaphroditism (HP:0010459)3.30710185
16Dialeptic seizures (HP:0011146)3.28089589
17Absence seizures (HP:0002121)3.22170238
18Aplasia involving bones of the extremities (HP:0009825)3.20614885
19Aplasia involving bones of the upper limbs (HP:0009823)3.20614885
20Aplasia of the phalanges of the hand (HP:0009802)3.20614885
21Generalized tonic-clonic seizures (HP:0002069)3.05187578
22Progressive cerebellar ataxia (HP:0002073)3.03714287
23Sensory axonal neuropathy (HP:0003390)2.94656415
24Dysmetria (HP:0001310)2.93100897
25Intestinal atresia (HP:0011100)2.88595119
26Spastic gait (HP:0002064)2.87514037
27Hemiparesis (HP:0001269)2.87218553
28Nephronophthisis (HP:0000090)2.84076710
29Pancreatic fibrosis (HP:0100732)2.82926659
30Diplopia (HP:0000651)2.68786751
31Abnormality of binocular vision (HP:0011514)2.68786751
32Akinesia (HP:0002304)2.68769777
33Peripheral hypomyelination (HP:0007182)2.68532107
34Parakeratosis (HP:0001036)2.67869798
35Molar tooth sign on MRI (HP:0002419)2.66523693
36Abnormality of midbrain morphology (HP:0002418)2.66523693
37Abnormal eating behavior (HP:0100738)2.65623036
38Nephrogenic diabetes insipidus (HP:0009806)2.65609441
39Clumsiness (HP:0002312)2.65121819
40Action tremor (HP:0002345)2.63973398
41Dysdiadochokinesis (HP:0002075)2.63786649
42Polyphagia (HP:0002591)2.59026705
43Truncal ataxia (HP:0002078)2.58205960
44Gaze-evoked nystagmus (HP:0000640)2.57496540
45Pancreatic cysts (HP:0001737)2.55264841
46Drooling (HP:0002307)2.54410541
47Excessive salivation (HP:0003781)2.54410541
48Progressive inability to walk (HP:0002505)2.49766493
49Scanning speech (HP:0002168)2.45505237
50Intention tremor (HP:0002080)2.45504203
51Oligodactyly (hands) (HP:0001180)2.45024917
52Insidious onset (HP:0003587)2.43924036
53Termporal pattern (HP:0011008)2.43924036
54Absent speech (HP:0001344)2.43778101
55Ankle clonus (HP:0011448)2.42565647
56Oligodactyly (HP:0012165)2.40921425
57Abnormality of the renal medulla (HP:0100957)2.39889201
58Type II lissencephaly (HP:0007260)2.38780102
59Megalencephaly (HP:0001355)2.38143292
60Visual hallucinations (HP:0002367)2.35111853
61Blue irides (HP:0000635)2.34833902
62Thickened helices (HP:0000391)2.32267938
63Widely spaced teeth (HP:0000687)2.32232090
64Agitation (HP:0000713)2.28012260
65Abnormality of the labia minora (HP:0012880)2.26177315
66Postaxial hand polydactyly (HP:0001162)2.26102964
67Retinal dysplasia (HP:0007973)2.25924731
68Abnormal hair whorl (HP:0010721)2.21580516
69Synostosis involving the elbow (HP:0003938)2.17959318
70Humeroradial synostosis (HP:0003041)2.17959318
71Lower limb muscle weakness (HP:0007340)2.16603350
72Tubulointerstitial nephritis (HP:0001970)2.16231489
73Inability to walk (HP:0002540)2.15089485
74Fetal akinesia sequence (HP:0001989)2.13364530
75Impaired vibration sensation in the lower limbs (HP:0002166)2.12027304
76Progressive macrocephaly (HP:0004481)2.10724365
77Pendular nystagmus (HP:0012043)2.10574156
78Epileptiform EEG discharges (HP:0011182)2.09306931
79Poor eye contact (HP:0000817)2.07686896
80Absent/shortened dynein arms (HP:0200106)2.05948200
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.05948200
82Pheochromocytoma (HP:0002666)2.05717778
83Colon cancer (HP:0003003)2.05537103
84Acute necrotizing encephalopathy (HP:0006965)2.05470451
85Urinary bladder sphincter dysfunction (HP:0002839)2.05391901
86Gait imbalance (HP:0002141)2.04765381
87Postaxial foot polydactyly (HP:0001830)2.04758716
88Generalized myoclonic seizures (HP:0002123)2.02496494
89Anxiety (HP:0000739)2.01411149
90Hyperglycinemia (HP:0002154)2.00902403
91Amblyopia (HP:0000646)1.99762686
92Lissencephaly (HP:0001339)1.98808726
93Abnormality of the renal cortex (HP:0011035)1.98675701
94Abolished electroretinogram (ERG) (HP:0000550)1.97510898
95Methylmalonic acidemia (HP:0002912)1.97174670
96Postural instability (HP:0002172)1.97041475
97Abnormal drinking behavior (HP:0030082)1.96961128
98Polydipsia (HP:0001959)1.96961128
99Medial flaring of the eyebrow (HP:0010747)1.96948171
100Labial hypoplasia (HP:0000066)1.96697685
101Abnormality of salivation (HP:0100755)1.96358307
102Cupped ear (HP:0000378)1.95691229
103Cerebellar dysplasia (HP:0007033)1.94927883
104Increased circulating renin level (HP:0000848)1.93202419
105EEG with generalized epileptiform discharges (HP:0011198)1.92844807
106Tubulointerstitial abnormality (HP:0001969)1.90707421
107Cystic liver disease (HP:0006706)1.90398048
108Protruding tongue (HP:0010808)1.88843514
109Esotropia (HP:0000565)1.88631840
110Tubular atrophy (HP:0000092)1.88600051
111Alacrima (HP:0000522)1.88488843
112Volvulus (HP:0002580)1.86985380
113Slow saccadic eye movements (HP:0000514)1.85652436
114Vaginal atresia (HP:0000148)1.85494327
115Genital tract atresia (HP:0001827)1.85290660
116Abnormal mitochondria in muscle tissue (HP:0008316)1.84708651
117Mixed hearing impairment (HP:0000410)1.83387697
118Limb dystonia (HP:0002451)1.82482459
119Renal hypoplasia (HP:0000089)1.82370231
120Increased serum pyruvate (HP:0003542)1.81482046
121Abnormality of glycolysis (HP:0004366)1.81482046
122Aqueductal stenosis (HP:0002410)1.81283193
123Neuroendocrine neoplasm (HP:0100634)1.80013782
124Narrow nasal bridge (HP:0000446)1.79383509
125Acute encephalopathy (HP:0006846)1.78824054
126Hypsarrhythmia (HP:0002521)1.77868461
127Impaired social interactions (HP:0000735)1.77236202
128Abnormal social behavior (HP:0012433)1.77236202
129Poor coordination (HP:0002370)1.77087303
130Absent septum pellucidum (HP:0001331)1.75062147
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.74669938
132Gastroesophageal reflux (HP:0002020)1.73657265
133Hypoplastic left heart (HP:0004383)1.73554367
134Depression (HP:0000716)1.73431505
135Amyotrophic lateral sclerosis (HP:0007354)1.73044533
136Onion bulb formation (HP:0003383)1.72828754
137Abnormality of the middle phalanges of the toes (HP:0010183)1.71734754
138Hypoplastic female external genitalia (HP:0012815)1.69543938
139Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69506748
140Specific learning disability (HP:0001328)1.69313930
141Status epilepticus (HP:0002133)1.69264248
142Chronic hepatic failure (HP:0100626)1.69141183
143Congenital primary aphakia (HP:0007707)1.68241482
144Stereotypic behavior (HP:0000733)1.67742815
145Broad foot (HP:0001769)1.67199983
146Gastrointestinal atresia (HP:0002589)1.66618582
147Abnormal sex determination (HP:0012244)1.65821453
148Sex reversal (HP:0012245)1.65821453
149Pachygyria (HP:0001302)1.65498530
150Short foot (HP:0001773)1.65483924
151Hemiplegia (HP:0002301)1.63234092
152Spastic tetraplegia (HP:0002510)1.63170707
153Tubulointerstitial fibrosis (HP:0005576)1.62910698
154Narrow forehead (HP:0000341)1.62418430
155Sclerocornea (HP:0000647)1.61088552
156Retinitis pigmentosa (HP:0000510)1.60545329
157Congenital hepatic fibrosis (HP:0002612)1.60170362
158Cerebral hypomyelination (HP:0006808)1.59647674
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.58596868
160Astrocytoma (HP:0009592)1.58560046
161Abnormality of the astrocytes (HP:0100707)1.58560046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.56379634
2EPHA44.01820932
3NTRK33.47189424
4MAP4K23.31974383
5TNIK3.23458213
6STK392.82785752
7MARK12.68515646
8OXSR12.67855925
9FRK2.56600906
10MAP2K72.23226533
11CDK192.17299338
12MAP3K42.11057222
13NTRK22.07524248
14MUSK2.03367529
15PNCK1.98677084
16PINK11.92798479
17PAK61.72313836
18MAP3K91.71398996
19MAPK131.70310836
20PRPF4B1.69043505
21DAPK21.67918003
22MINK11.60721175
23MKNK21.60385933
24BCR1.59922373
25PLK21.51291457
26NTRK11.46947909
27ERBB31.45819689
28MAP3K121.43843210
29RIPK41.38477291
30MKNK11.35305537
31CDK51.30029064
32PKN11.29875390
33CAMKK21.28615408
34FGR1.25072824
35EPHA31.24942918
36CAMK2B1.22724082
37CAMK2A1.21845470
38NEK61.18266113
39SGK2231.15152153
40SGK4941.15152153
41PHKG21.14645541
42PHKG11.14645541
43UHMK11.13038436
44MAPK151.12837804
45FES1.11933526
46FGFR21.08625888
47TRIM281.07978134
48MAP2K41.05588294
49GRK11.05052806
50WNK41.04126626
51PRKCG1.02537855
52CSNK1G20.98455282
53STK38L0.97895007
54TYRO30.96967341
55DYRK30.95546022
56BMPR20.94191231
57EPHB10.92656784
58GRK50.92145065
59PRKCE0.91560425
60MAPKAPK50.91280618
61CAMK2D0.90965153
62PAK30.88300857
63KSR10.86986946
64TSSK60.86184154
65PTK2B0.82669570
66CDK140.80820536
67WNK10.80667888
68CDK180.80379872
69CDK150.78455649
70ROCK20.78112820
71SIK20.77683989
72ERBB40.76803606
73MST40.76626544
74BRD40.76065581
75DAPK10.72954175
76CAMK2G0.71787759
77CSNK1G30.71273755
78BCKDK0.70861479
79DYRK1A0.69704323
80BMPR1B0.69459219
81CAMK1G0.69334098
82FER0.69159011
83CSNK1A1L0.67447108
84GRK70.67280411
85CDK11A0.66999504
86MARK20.65813168
87ICK0.65778079
88WEE10.63762564
89SGK10.62860738
90ADRBK20.62709535
91PBK0.61594482
92CCNB10.61343632
93SGK20.61049555
94CAMKK10.59929128
95AKT30.59407864
96ARAF0.59229674
97WNK30.58487466
98INSRR0.58104451
99MAPK70.57688700
100STK110.57121190
101BRSK10.56565612
102PRKCQ0.55691527
103NME10.55601284
104PRKD30.54325786
105DYRK20.52879775
106NEK10.52656760
107MAPK120.52119875
108KSR20.51561833
109ACVR1B0.51185122
110CDK30.49282166
111CAMK10.49215370
112PRKCZ0.48146668
113FYN0.47530182
114ERBB20.47146021
115PRKG10.45850510
116ADRBK10.44971508
117CSNK1G10.44589160
118PRKACA0.44483748
119CSNK1D0.40937579
120MAP3K130.40827952
121RPS6KA40.39411783
122PLK30.38723921
123TNK20.38507739
124PRKCH0.38268917
125PDPK10.37823944
126PRKACB0.37489409
127CSNK1A10.36650748
128NUAK10.36442804
129LIMK10.36190203
130CAMK40.35486483
131CSNK1E0.32893568

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98365367
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74238551
3GABAergic synapse_Homo sapiens_hsa047272.71335011
4Glutamatergic synapse_Homo sapiens_hsa047242.67093264
5Synaptic vesicle cycle_Homo sapiens_hsa047212.63828150
6Morphine addiction_Homo sapiens_hsa050322.55596469
7Protein export_Homo sapiens_hsa030602.48401640
8Circadian entrainment_Homo sapiens_hsa047132.36744985
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.13820936
10Serotonergic synapse_Homo sapiens_hsa047262.10388159
11Collecting duct acid secretion_Homo sapiens_hsa049662.03345583
12Salivary secretion_Homo sapiens_hsa049702.02941904
13Steroid biosynthesis_Homo sapiens_hsa001002.01201651
14Long-term potentiation_Homo sapiens_hsa047202.01068738
15Amphetamine addiction_Homo sapiens_hsa050311.97604994
16Olfactory transduction_Homo sapiens_hsa047401.90478638
17Taste transduction_Homo sapiens_hsa047421.87825157
18Dopaminergic synapse_Homo sapiens_hsa047281.82907880
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81630588
20Axon guidance_Homo sapiens_hsa043601.77825824
21Long-term depression_Homo sapiens_hsa047301.72926258
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.71652628
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66211756
24Gastric acid secretion_Homo sapiens_hsa049711.61502312
25Fatty acid elongation_Homo sapiens_hsa000621.56510504
26Insulin secretion_Homo sapiens_hsa049111.56240284
27Cholinergic synapse_Homo sapiens_hsa047251.54575062
28Renin secretion_Homo sapiens_hsa049241.53509713
29Cocaine addiction_Homo sapiens_hsa050301.53237341
30Propanoate metabolism_Homo sapiens_hsa006401.51117784
31Calcium signaling pathway_Homo sapiens_hsa040201.50052806
32Oxidative phosphorylation_Homo sapiens_hsa001901.48795821
33Ether lipid metabolism_Homo sapiens_hsa005651.37111287
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34964161
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30882353
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30149779
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30127879
38Oxytocin signaling pathway_Homo sapiens_hsa049211.28543711
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26674551
40Vibrio cholerae infection_Homo sapiens_hsa051101.23553162
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22941363
42Cardiac muscle contraction_Homo sapiens_hsa042601.20369817
43Peroxisome_Homo sapiens_hsa041461.16152707
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16074945
45Alzheimers disease_Homo sapiens_hsa050101.14550497
46beta-Alanine metabolism_Homo sapiens_hsa004101.14444181
47Fatty acid biosynthesis_Homo sapiens_hsa000611.13349234
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12155297
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11258952
50Gap junction_Homo sapiens_hsa045401.11032660
51Regulation of autophagy_Homo sapiens_hsa041401.08827434
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08573966
53Phototransduction_Homo sapiens_hsa047441.08416992
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07865472
55cAMP signaling pathway_Homo sapiens_hsa040241.04615083
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02475289
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97648681
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95595619
59Hedgehog signaling pathway_Homo sapiens_hsa043400.93055391
60Sphingolipid metabolism_Homo sapiens_hsa006000.90182171
61ErbB signaling pathway_Homo sapiens_hsa040120.89081090
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.87851930
63GnRH signaling pathway_Homo sapiens_hsa049120.87732392
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85330764
65Parkinsons disease_Homo sapiens_hsa050120.85208976
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83164016
67Rheumatoid arthritis_Homo sapiens_hsa053230.82994416
68Vitamin B6 metabolism_Homo sapiens_hsa007500.81095472
69Melanogenesis_Homo sapiens_hsa049160.79107383
70Pancreatic secretion_Homo sapiens_hsa049720.78721516
71Arginine and proline metabolism_Homo sapiens_hsa003300.78049840
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76528377
73Histidine metabolism_Homo sapiens_hsa003400.75794747
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.74325550
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73943705
76Dorso-ventral axis formation_Homo sapiens_hsa043200.73099090
77Ras signaling pathway_Homo sapiens_hsa040140.72049882
78Folate biosynthesis_Homo sapiens_hsa007900.69780763
79Hippo signaling pathway_Homo sapiens_hsa043900.69762995
80Basal cell carcinoma_Homo sapiens_hsa052170.68965503
81Oocyte meiosis_Homo sapiens_hsa041140.67584179
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.65584255
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64796038
84Fanconi anemia pathway_Homo sapiens_hsa034600.63796542
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62414592
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62323354
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61304838
88Choline metabolism in cancer_Homo sapiens_hsa052310.60453259
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60346468
90Estrogen signaling pathway_Homo sapiens_hsa049150.60068539
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.60031684
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58889680
93MAPK signaling pathway_Homo sapiens_hsa040100.58114356
94Butanoate metabolism_Homo sapiens_hsa006500.58001010
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57711191
96Linoleic acid metabolism_Homo sapiens_hsa005910.56755422
97African trypanosomiasis_Homo sapiens_hsa051430.55572095
98Dilated cardiomyopathy_Homo sapiens_hsa054140.55370384
99Ovarian steroidogenesis_Homo sapiens_hsa049130.55290713
100Basal transcription factors_Homo sapiens_hsa030220.54658425
101Huntingtons disease_Homo sapiens_hsa050160.53960051
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53953655
103ABC transporters_Homo sapiens_hsa020100.53865067
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50039137
105Glioma_Homo sapiens_hsa052140.48601636
106Mineral absorption_Homo sapiens_hsa049780.48384050
107Renal cell carcinoma_Homo sapiens_hsa052110.47430159
108Tryptophan metabolism_Homo sapiens_hsa003800.47375002
109Thyroid hormone synthesis_Homo sapiens_hsa049180.45624109
110Selenocompound metabolism_Homo sapiens_hsa004500.45408530
111Arginine biosynthesis_Homo sapiens_hsa002200.44352323
112Type II diabetes mellitus_Homo sapiens_hsa049300.43843087
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42859939
114Bile secretion_Homo sapiens_hsa049760.41819635
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40938504
116Rap1 signaling pathway_Homo sapiens_hsa040150.40055024
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39876837
118Nitrogen metabolism_Homo sapiens_hsa009100.39692753
119Wnt signaling pathway_Homo sapiens_hsa043100.39096093
120Circadian rhythm_Homo sapiens_hsa047100.38796140
121Alcoholism_Homo sapiens_hsa050340.38747433
122Phagosome_Homo sapiens_hsa041450.38661998
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.36359484
124Fatty acid metabolism_Homo sapiens_hsa012120.35247709
125Sulfur metabolism_Homo sapiens_hsa009200.32090726
126Inositol phosphate metabolism_Homo sapiens_hsa005620.30501416
127Endocytosis_Homo sapiens_hsa041440.28550273
128Tight junction_Homo sapiens_hsa045300.26518919
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26119138
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25525281

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