CDCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.45979297
2desmosome organization (GO:0002934)7.42742684
3bundle of His cell to Purkinje myocyte communication (GO:0086069)7.34244751
4interferon-gamma secretion (GO:0072643)6.27605799
5regulation of water loss via skin (GO:0033561)5.32925909
6establishment of skin barrier (GO:0061436)4.76396740
7negative regulation of keratinocyte proliferation (GO:0010839)4.72413413
8hepatocyte apoptotic process (GO:0097284)4.65418707
9positive regulation of actin filament depolymerization (GO:0030836)4.59433050
10negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.54068199
11intestinal epithelial cell development (GO:0060576)4.44461080
12protein maturation by protein folding (GO:0022417)4.36926270
13multicellular organismal water homeostasis (GO:0050891)4.29351924
14hypotonic response (GO:0006971)4.04675888
15renal absorption (GO:0070293)3.88766626
16mesodermal cell differentiation (GO:0048333)3.81869517
17Golgi transport vesicle coating (GO:0048200)3.69893962
18COPI coating of Golgi vesicle (GO:0048205)3.69893962
19peptide catabolic process (GO:0043171)3.66158856
20regulation of type B pancreatic cell apoptotic process (GO:2000674)3.61111897
21protein localization to endosome (GO:0036010)3.58793458
22water homeostasis (GO:0030104)3.57055210
23muscle cell migration (GO:0014812)3.55287199
24membrane raft organization (GO:0031579)3.49936187
25regulation of metalloenzyme activity (GO:0048552)3.43236965
26growth hormone receptor signaling pathway (GO:0060396)3.40332216
27regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.40232881
28keratinocyte differentiation (GO:0030216)3.39539235
29cellular response to vitamin D (GO:0071305)3.39207037
30COPII vesicle coating (GO:0048208)3.37857031
31keratinocyte proliferation (GO:0043616)3.35909860
32keratinocyte development (GO:0003334)3.32094095
33keratinization (GO:0031424)3.30976481
34cell-substrate junction assembly (GO:0007044)3.29160468
35surfactant homeostasis (GO:0043129)3.26611305
36substrate-dependent cell migration (GO:0006929)3.26554538
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26293714
38regulation of chemokine secretion (GO:0090196)3.26192571
39tight junction assembly (GO:0070830)3.24293285
40mitotic nuclear envelope reassembly (GO:0007084)3.19321068
41nuclear envelope reassembly (GO:0031468)3.19321068
42antigen processing and presentation of endogenous antigen (GO:0019883)3.14980861
43adhesion of symbiont to host cell (GO:0044650)3.12540178
44virion attachment to host cell (GO:0019062)3.12540178
45activation of Rac GTPase activity (GO:0032863)3.11914912
46regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.10968401
47positive regulation of pseudopodium assembly (GO:0031274)3.10030135
48intestinal cholesterol absorption (GO:0030299)3.08185100
49nucleotide-sugar biosynthetic process (GO:0009226)3.07950350
50hepatocyte differentiation (GO:0070365)3.06437667
51ER overload response (GO:0006983)3.06126266
52gland morphogenesis (GO:0022612)3.05747765
53mammary gland epithelial cell proliferation (GO:0033598)3.05647044
54positive regulation of epidermal cell differentiation (GO:0045606)3.04553729
55actin filament depolymerization (GO:0030042)3.03630681
56regulation of keratinocyte proliferation (GO:0010837)3.03518357
57maintenance of gastrointestinal epithelium (GO:0030277)3.03050176
58negative regulation of protein tyrosine kinase activity (GO:0061099)3.02627810
59calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.02178750
60intestinal absorption (GO:0050892)3.01717156
61dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.97683294
62positive regulation of positive chemotaxis (GO:0050927)2.97547325
63cellular response to vitamin (GO:0071295)2.95132267
64iron ion import (GO:0097286)2.94517479
65regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.91555143
66regulation of transmission of nerve impulse (GO:0051969)2.90539969
67skin morphogenesis (GO:0043589)2.89781421
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89076255
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89076255
70protein hydroxylation (GO:0018126)2.87702870
71lung lobe morphogenesis (GO:0060463)2.87521884
72response to gravity (GO:0009629)2.87128940
73positive regulation of Cdc42 GTPase activity (GO:0043089)2.86775881
74cellular copper ion homeostasis (GO:0006878)2.86363720
75UDP-N-acetylglucosamine metabolic process (GO:0006047)2.86119289
76zinc ion transmembrane transport (GO:0071577)2.85943751
77cellular response to growth hormone stimulus (GO:0071378)2.85522183
78epithelial cell differentiation involved in prostate gland development (GO:0060742)2.85067535
79glomerular visceral epithelial cell development (GO:0072015)2.82850797
80protein retention in ER lumen (GO:0006621)2.82714926
81regulation of positive chemotaxis (GO:0050926)2.80617042
82branching involved in labyrinthine layer morphogenesis (GO:0060670)2.78593953
83membrane budding (GO:0006900)2.78008415
84negative regulation of chondrocyte differentiation (GO:0032331)2.76623370
85one-carbon compound transport (GO:0019755)2.76450040
86endothelial cell chemotaxis (GO:0035767)2.75993979
87regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.75799090
88negative regulation of cell fate specification (GO:0009996)2.74710003
89lactate metabolic process (GO:0006089)2.73610459
90detection of bacterium (GO:0016045)2.73250515
91regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.73101211
92ectoderm development (GO:0007398)2.72861461
93positive regulation of p38MAPK cascade (GO:1900745)2.72311173
94regulation of natural killer cell differentiation (GO:0032823)2.72273439
95epithelial cell-cell adhesion (GO:0090136)2.70151610
96O-glycan processing (GO:0016266)2.68540215
97columnar/cuboidal epithelial cell development (GO:0002066)2.68262248
98establishment of epithelial cell polarity (GO:0090162)2.68102771
99wound healing, spreading of epidermal cells (GO:0035313)2.67737521
100glandular epithelial cell differentiation (GO:0002067)2.67612205
101regulation of cardioblast proliferation (GO:0003264)2.67168250
102regulation of secondary heart field cardioblast proliferation (GO:0003266)2.67168250
103regulation of pseudopodium assembly (GO:0031272)2.65994173
104adhesion of symbiont to host (GO:0044406)2.65853759
105protein autoprocessing (GO:0016540)2.65503211
106inositol phosphate-mediated signaling (GO:0048016)2.65436157
107detection of other organism (GO:0098543)2.65409741
108sphingomyelin metabolic process (GO:0006684)2.65402935
109cell adhesion mediated by integrin (GO:0033627)2.65238720
110positive regulation of epidermis development (GO:0045684)2.64766397
111diterpenoid biosynthetic process (GO:0016102)2.64673312
112epidermal cell differentiation (GO:0009913)2.64450334
113regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64048523
114ventricular cardiac muscle cell action potential (GO:0086005)2.63407220
115establishment of integrated proviral latency (GO:0075713)2.63320564
116hormone catabolic process (GO:0042447)2.62368236
117epithelial structure maintenance (GO:0010669)2.62047556
118epidermis development (GO:0008544)2.59357279
119exocrine pancreas development (GO:0031017)2.59262337
120lung vasculature development (GO:0060426)2.58539881
121positive regulation of glycoprotein metabolic process (GO:1903020)2.57370076
122type B pancreatic cell proliferation (GO:0044342)2.56551147
123chemical homeostasis within a tissue (GO:0048875)2.55099154
124renal system development (GO:0072001)2.54095416
125protein localization to microtubule (GO:0035372)2.53017746
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.52882228
127negative regulation of acute inflammatory response (GO:0002674)2.51437581
128positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.51430066
129regulation of transforming growth factor beta2 production (GO:0032909)2.51101511
130polarized epithelial cell differentiation (GO:0030859)2.50919722
131regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50134729
132glomerular epithelial cell development (GO:0072310)2.48139887
133vesicle coating (GO:0006901)2.47283813
134SMAD protein complex assembly (GO:0007183)2.46444257
135drug transmembrane transport (GO:0006855)2.46110414
136regulation of cholesterol homeostasis (GO:2000188)2.45091941
1373-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.44392052
138purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.44392052
139mesenchymal cell differentiation involved in renal system development (GO:2001012)2.44053099
140mesenchymal cell differentiation involved in kidney development (GO:0072161)2.44053099
141gap junction assembly (GO:0016264)2.43956544
142trophectodermal cell differentiation (GO:0001829)2.43942154
143response to progesterone (GO:0032570)2.42956057
144regulation of keratinocyte differentiation (GO:0045616)2.42396702
145regulation of translational termination (GO:0006449)2.41753083
146toxin transport (GO:1901998)2.41621041
147positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.41068775
148response to vitamin D (GO:0033280)2.40571201
149negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.40110931
150positive regulation of glycoprotein biosynthetic process (GO:0010560)2.39945054
151ganglion development (GO:0061548)2.39121034
152sphingosine metabolic process (GO:0006670)2.38518049
153positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.38203155
154regulation of gonadotropin secretion (GO:0032276)2.37986694
155zinc ion transport (GO:0006829)2.37875386
156cytoskeletal anchoring at plasma membrane (GO:0007016)2.37550853
157response to hepatocyte growth factor (GO:0035728)2.37472254
158cellular response to hepatocyte growth factor stimulus (GO:0035729)2.37472254
159cell-cell junction assembly (GO:0007043)2.37451520
160regulation of cell fate specification (GO:0042659)2.36982140
161branching involved in mammary gland duct morphogenesis (GO:0060444)2.35175570
162pattern specification involved in kidney development (GO:0061004)2.35031433
163regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.34852257
1644-hydroxyproline metabolic process (GO:0019471)2.34547700
165regulation of interleukin-8 secretion (GO:2000482)2.34491339
166xenobiotic catabolic process (GO:0042178)2.33908195
167positive regulation of natural killer cell differentiation (GO:0032825)2.33785758
168diol metabolic process (GO:0034311)2.33308866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.84377037
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.79118496
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.51474336
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.95829161
5STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.72210126
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.68271818
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.56639218
8ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.36182985
9SOX2_20726797_ChIP-Seq_SW620_Human2.32867073
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.26721389
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.26628546
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.26628546
13FOXO3_23340844_ChIP-Seq_DLD1_Human2.20159178
14AR_21909140_ChIP-Seq_LNCAP_Human2.19809207
15FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.19296422
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.15150440
17GATA1_22025678_ChIP-Seq_K562_Human2.12079624
18* GATA4_25053715_ChIP-Seq_YYC3_Human2.11801705
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03317497
20* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.01272802
21CLOCK_20551151_ChIP-Seq_293T_Human2.00626521
22TP63_17297297_ChIP-ChIP_HaCaT_Human10.6976027
23GATA6_25053715_ChIP-Seq_YYC3_Human1.98508081
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95568786
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86965071
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85915353
27* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.84574058
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84304849
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79685423
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.78078035
31ZNF263_19887448_ChIP-Seq_K562_Human1.75548691
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75243939
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74078243
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71621719
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67294650
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66871173
37FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.66233102
38* LXR_22158963_ChIP-Seq_LIVER_Mouse1.65991205
39* RUNX1_27514584_Chip-Seq_MCF-7_Human1.64067415
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.60719304
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59410317
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57199479
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56235905
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50371181
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48957161
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.48625506
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.46309060
48KLF5_25053715_ChIP-Seq_YYC3_Human1.45277507
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.43768753
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42197036
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.41953477
52* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39955798
53* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39416192
54RACK7_27058665_Chip-Seq_MCF-7_Human1.38934730
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36629996
56AHR_22903824_ChIP-Seq_MCF-7_Human1.35543868
57* CJUN_26792858_Chip-Seq_BT549_Human1.35152127
58FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26305443
59TP63_23658742_ChIP-Seq_EP156T_Human1.23335094
60* TCF4_18268006_ChIP-ChIP_LS174T_Human1.22639582
61ATF3_27146783_Chip-Seq_COLON_Human1.20587056
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18695156
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18394483
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17486097
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16135663
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13457498
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13082735
68ELK1_19687146_ChIP-ChIP_HELA_Human1.12991634
69ELF5_23300383_ChIP-Seq_T47D_Human1.09958190
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09764790
71DCP1A_22483619_ChIP-Seq_HELA_Human1.09514359
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08808669
73AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08482307
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06591691
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05887142
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.05458611
77* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05422102
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04086894
79TFEB_21752829_ChIP-Seq_HELA_Human1.03860156
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.03073232
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.03053712
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01487665
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01231584
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.00747936
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00181317
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00154844
87* CHD1_26751641_Chip-Seq_LNCaP_Human0.99905608
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98979320
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97948898
90KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97335984
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96187855
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.95706725
93CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95595316
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94500328
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94471839
96NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93849859
97IRF8_22096565_ChIP-ChIP_GC-B_Human0.93343720
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93004688
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.92957326
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92435224
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91404604
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90309545
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.89609302
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.88962684
105MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87983921
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87955954
107TP53_22127205_ChIP-Seq_IMR90_Human0.87532639
108NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86782253
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85732750
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84868266
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84868266
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83544420
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83448128
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83028613
115KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82731742
116* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80938888
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.79934847
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78436631
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77869374
120RXR_22108803_ChIP-Seq_LS180_Human0.77501773
121GABP_17652178_ChIP-ChIP_JURKAT_Human0.77242066
122E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77184557
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.77000027
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76677092
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75598196
126CDX2_22108803_ChIP-Seq_LS180_Human0.74878019
127* GATA2_19941826_ChIP-Seq_K562_Human0.74451089
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73826753
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73778808
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.73552529
131TP53_18474530_ChIP-ChIP_U2OS_Human0.73458469
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.72965445
133EGR1_19032775_ChIP-ChIP_M12_Human0.69797092
134BRD4_25478319_ChIP-Seq_HGPS_Human0.66779177
135IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.66466330
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.66162232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.15735027
2MP0010234_abnormal_vibrissa_follicle5.75138967
3MP0004264_abnormal_extraembryonic_tissu3.48737245
4MP0002796_impaired_skin_barrier3.05957014
5MP0003950_abnormal_plasma_membrane2.94439003
6MP0010678_abnormal_skin_adnexa2.76657144
7MP0001346_abnormal_lacrimal_gland2.74252100
8MP0002098_abnormal_vibrissa_morphology2.64400805
9MP0000383_abnormal_hair_follicle2.41972280
10MP0003453_abnormal_keratinocyte_physiol2.38413484
11MP0000566_synostosis2.31490475
12MP0000579_abnormal_nail_morphology2.28438082
13MP0003300_gastrointestinal_ulcer2.23849364
14MP0003191_abnormal_cellular_cholesterol2.18100664
15MP0002877_abnormal_melanocyte_morpholog2.13798585
16MP0003941_abnormal_skin_development2.08369300
17MP0001216_abnormal_epidermal_layer2.04748570
18MP0002060_abnormal_skin_morphology2.02025512
19MP0005257_abnormal_intraocular_pressure1.96855940
20MP0000537_abnormal_urethra_morphology1.96478802
21MP0001849_ear_inflammation1.88497313
22MP0005501_abnormal_skin_physiology1.86663487
23MP0002138_abnormal_hepatobiliary_system1.85921167
24MP0003566_abnormal_cell_adhesion1.85782972
25MP0000467_abnormal_esophagus_morphology1.77207739
26MP0001666_abnormal_nutrient_absorption1.75444170
27MP0000762_abnormal_tongue_morphology1.74114120
28MP0001881_abnormal_mammary_gland1.71174348
29MP0004019_abnormal_vitamin_homeostasis1.68046669
30MP0000013_abnormal_adipose_tissue1.67006445
31MP0004947_skin_inflammation1.64213419
32MP0000377_abnormal_hair_follicle1.56920379
33MP0005275_abnormal_skin_tensile1.56658661
34MP0004782_abnormal_surfactant_physiolog1.53629593
35MP0009840_abnormal_foam_cell1.49546337
36MP0000516_abnormal_urinary_system1.47982678
37MP0005367_renal/urinary_system_phenotyp1.47982678
38MP0010352_gastrointestinal_tract_polyps1.46326609
39MP0000538_abnormal_urinary_bladder1.45683762
40MP0001873_stomach_inflammation1.44419684
41MP0003315_abnormal_perineum_morphology1.43404433
42MP0000613_abnormal_salivary_gland1.43223174
43MP0002006_tumorigenesis1.41709867
44MP0008789_abnormal_olfactory_epithelium1.38230590
45MP0002234_abnormal_pharynx_morphology1.35399127
46MP0005310_abnormal_salivary_gland1.34078671
47MP0000462_abnormal_digestive_system1.33140155
48MP0009697_abnormal_copulation1.32097985
49MP0005085_abnormal_gallbladder_physiolo1.31379690
50MP0000427_abnormal_hair_cycle1.31357453
51MP0010771_integument_phenotype1.30759744
52MP0003705_abnormal_hypodermis_morpholog1.29691815
53MP0000678_abnormal_parathyroid_gland1.29149575
54MP0000627_abnormal_mammary_gland1.28687138
55MP0004510_myositis1.27548337
56MP0005165_increased_susceptibility_to1.25945518
57MP0003806_abnormal_nucleotide_metabolis1.24240618
58MP0005360_urolithiasis1.23975146
59MP0005164_abnormal_response_to1.22440731
60MP0009053_abnormal_anal_canal1.22404438
61MP0010155_abnormal_intestine_physiology1.19273923
62MP0009643_abnormal_urine_homeostasis1.17366301
63MP0005248_abnormal_Harderian_gland1.15321788
64MP0004272_abnormal_basement_membrane1.14385166
65MP0005023_abnormal_wound_healing1.13474666
66MP0001765_abnormal_ion_homeostasis1.13259782
67MP0000003_abnormal_adipose_tissue1.12748746
68MP0003866_abnormal_defecation1.12148178
69MP0006054_spinal_hemorrhage1.11658707
70MP0005409_darkened_coat_color1.11567738
71MP0008004_abnormal_stomach_pH1.10831800
72MP0002876_abnormal_thyroid_physiology1.06688895
73MP0005365_abnormal_bile_salt1.05842816
74MP0008875_abnormal_xenobiotic_pharmacok1.05289926
75MP0002139_abnormal_hepatobiliary_system1.04362479
76MP0002277_abnormal_respiratory_mucosa1.02493191
77MP0000470_abnormal_stomach_morphology0.99929629
78MP0003195_calcinosis0.99496812
79MP0001191_abnormal_skin_condition0.97655804
80MP0005220_abnormal_exocrine_pancreas0.96520222
81MP0003091_abnormal_cell_migration0.96352062
82MP0002177_abnormal_outer_ear0.96233524
83MP0002896_abnormal_bone_mineralization0.95794222
84MP0002332_abnormal_exercise_endurance0.94400506
85MP0005076_abnormal_cell_differentiation0.94363496
86MP0009931_abnormal_skin_appearance0.92355279
87MP0002009_preneoplasia0.91908060
88MP0003123_paternal_imprinting0.91291986
89MP0000647_abnormal_sebaceous_gland0.91017974
90MP0004043_abnormal_pH_regulation0.90893643
91MP0003183_abnormal_peptide_metabolism0.90705616
92MP0001299_abnormal_eye_distance/0.89935068
93MP0003252_abnormal_bile_duct0.88558892
94MP0003045_fibrosis0.86060163
95MP0008007_abnormal_cellular_replicative0.85426962
96MP0004185_abnormal_adipocyte_glucose0.85274022
97MP0003786_premature_aging0.84988749
98MP0002136_abnormal_kidney_physiology0.84137712
99MP0000477_abnormal_intestine_morphology0.83176770
100MP0001243_abnormal_dermal_layer0.80513316
101MP0009379_abnormal_foot_pigmentation0.80227905
102MP0005197_abnormal_uvea_morphology0.79689298
103MP0008438_abnormal_cutaneous_collagen0.79471999
104MP0004957_abnormal_blastocyst_morpholog0.79126559
105MP0002693_abnormal_pancreas_physiology0.78291989
106MP0002168_other_aberrant_phenotype0.77247320
107MP0005395_other_phenotype0.75482661
108MP0005083_abnormal_biliary_tract0.75110978
109MP0003943_abnormal_hepatobiliary_system0.74640563
110MP0005636_abnormal_mineral_homeostasis0.74363077
111MP0001756_abnormal_urination0.74180009
112MP0001944_abnormal_pancreas_morphology0.73613615
113MP0005499_abnormal_olfactory_system0.73526268
114MP0005394_taste/olfaction_phenotype0.73526268
115MP0010030_abnormal_orbit_morphology0.72915323
116MP0000465_gastrointestinal_hemorrhage0.72588343
117MP0003075_altered_response_to0.72259622
118MP0001664_abnormal_digestion0.71748873
119MP0002166_altered_tumor_susceptibility0.71153096
120MP0009780_abnormal_chondrocyte_physiolo0.70824641
121MP0003718_maternal_effect0.69266718
122MP0000685_abnormal_immune_system0.68128161
123MP0000367_abnormal_coat/_hair0.66847258
124MP0002233_abnormal_nose_morphology0.66715805
125MP0005623_abnormal_meninges_morphology0.65563333
126MP0003693_abnormal_embryo_hatching0.65401412
127MP0005166_decreased_susceptibility_to0.65064062
128MP0001727_abnormal_embryo_implantation0.64406043
129MP0003656_abnormal_erythrocyte_physiolo0.63614918
130MP0009384_cardiac_valve_regurgitation0.63214870
131MP0005381_digestive/alimentary_phenotyp0.61363083
132MP0000751_myopathy0.61343415
133MP0005330_cardiomyopathy0.57643573
134MP0004233_abnormal_muscle_weight0.57634108
135MP0005451_abnormal_body_composition0.57361280
136MP0001270_distended_abdomen0.57200731
137MP0002909_abnormal_adrenal_gland0.56597508
138MP0004381_abnormal_hair_follicle0.55798511
139MP0000858_altered_metastatic_potential0.55198517
140MP0003936_abnormal_reproductive_system0.54792607
141MP0001663_abnormal_digestive_system0.53946156

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.15363933
2Milia (HP:0001056)7.03949577
3Right ventricular cardiomyopathy (HP:0011663)6.42369654
4Fragile nails (HP:0001808)5.81707102
5Plantar hyperkeratosis (HP:0007556)5.44319694
6Pili torti (HP:0003777)5.38992974
7Atrophic scars (HP:0001075)5.18752315
8Lip pit (HP:0100267)4.18651696
9Hypoplasia of dental enamel (HP:0006297)3.90438026
10Short nail (HP:0001799)3.85602408
11Woolly hair (HP:0002224)3.71068443
12Palmoplantar hyperkeratosis (HP:0000972)3.49432106
13Nail dystrophy (HP:0008404)3.49106429
14Sparse eyelashes (HP:0000653)3.45827671
15Abnormal hair laboratory examination (HP:0003328)3.45420864
16Tongue fasciculations (HP:0001308)3.44041742
17Palmar hyperkeratosis (HP:0010765)3.35044314
18Hyperactive renin-angiotensin system (HP:0000841)3.24737131
19Abnormality of the gastric mucosa (HP:0004295)3.24093779
20Interstitial pulmonary disease (HP:0006530)3.09202032
21Abnormal blistering of the skin (HP:0008066)3.08638685
22Curly hair (HP:0002212)2.99886191
23Micronodular cirrhosis (HP:0001413)2.93826158
24Amelogenesis imperfecta (HP:0000705)2.93658546
25Muscle fibrillation (HP:0010546)2.88021990
26Thick nail (HP:0001805)2.86097450
27Alopecia of scalp (HP:0002293)2.82187688
28Gout (HP:0001997)2.75591514
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.75194069
30Osteolytic defects of the hand bones (HP:0009699)2.75194069
31Upper limb muscle weakness (HP:0003484)2.69121092
32Hydroxyprolinuria (HP:0003080)2.66764594
33Abnormality of proline metabolism (HP:0010907)2.66764594
34Aplasia cutis congenita (HP:0001057)2.66243961
35Abnormality of chloride homeostasis (HP:0011422)2.63981183
36Natal tooth (HP:0000695)2.61530386
37Pustule (HP:0200039)2.54719758
38Hypokinesia (HP:0002375)2.52468272
39Hypoplastic labia majora (HP:0000059)2.50843512
40Ankyloglossia (HP:0010296)2.48951393
41Premature rupture of membranes (HP:0001788)2.45812128
42Advanced eruption of teeth (HP:0006288)2.44378391
43Dehydration (HP:0001944)2.43222666
44Popliteal pterygium (HP:0009756)2.40619152
45Follicular hyperkeratosis (HP:0007502)2.40310672
46Ridged nail (HP:0001807)2.39048035
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.38095906
48Abnormality of purine metabolism (HP:0004352)2.34269301
49Hypotrichosis (HP:0001006)2.33445324
50Abdominal distention (HP:0003270)2.29396769
51Glucose intolerance (HP:0000833)2.28450535
52Symptomatic seizures (HP:0011145)2.26780915
53Fragile skin (HP:0001030)2.25704122
54Broad face (HP:0000283)2.24506941
55Insulin resistance (HP:0000855)2.24308015
56Biliary tract neoplasm (HP:0100574)2.23123683
57Pterygium (HP:0001059)2.22958684
58Hyperphosphatemia (HP:0002905)2.22879604
59Esophageal varix (HP:0002040)2.22347677
60Vascular calcification (HP:0004934)2.21906105
61Trismus (HP:0000211)2.21368999
62Abnormality of the labia majora (HP:0012881)2.21089828
63Abnormality of the distal phalanges of the toes (HP:0010182)2.20655627
64Hand muscle atrophy (HP:0009130)2.19614371
65Amniotic constriction ring (HP:0009775)2.18559437
66Abnormality of placental membranes (HP:0011409)2.18559437
67Distal upper limb amyotrophy (HP:0007149)2.18540460
68Upper limb amyotrophy (HP:0009129)2.18540460
69Villous atrophy (HP:0011473)2.17152865
70Abnormality of small intestinal villus morphology (HP:0011472)2.17152865
71Cervical subluxation (HP:0003308)2.15764623
72Palpitations (HP:0001962)2.14144098
73Fatigable weakness (HP:0003473)2.13709885
74Abnormality of the neuromuscular junction (HP:0003398)2.13709885
75Ureteral stenosis (HP:0000071)2.12313004
76Reduced subcutaneous adipose tissue (HP:0003758)2.11967261
77Increased IgE level (HP:0003212)2.10687522
78Abnormality of nail color (HP:0100643)2.10649010
79Glomerulosclerosis (HP:0000096)2.10032232
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09759819
81Focal segmental glomerulosclerosis (HP:0000097)2.09486918
82Esophageal atresia (HP:0002032)2.08456707
83Sparse scalp hair (HP:0002209)2.06756600
84Abnormal biliary tract morphology (HP:0012440)2.06290205
85Congenital ichthyosiform erythroderma (HP:0007431)2.06144822
86Stomach cancer (HP:0012126)2.06022057
87Abnormality of oral frenula (HP:0000190)2.05209267
88Blepharitis (HP:0000498)2.04884867
89Ureteral obstruction (HP:0006000)2.04535274
90Selective tooth agenesis (HP:0001592)2.03584877
91Oral leukoplakia (HP:0002745)2.02383084
92Unilateral renal agenesis (HP:0000122)2.02317860
93Rectal prolapse (HP:0002035)2.00384033
94Hyperinsulinemic hypoglycemia (HP:0000825)1.95455700
95Arterial tortuosity (HP:0005116)1.94553127
96Vertebral compression fractures (HP:0002953)1.94415485
97Hypoglycemic seizures (HP:0002173)1.92611783
98Ectropion (HP:0000656)1.92030371
99Hyperglycemia (HP:0003074)1.91584559
100Adrenal hypoplasia (HP:0000835)1.91448436
101Cardiovascular calcification (HP:0011915)1.91336657
102Urethral obstruction (HP:0000796)1.90783195
103Axonal loss (HP:0003447)1.90661986
104Increased purine levels (HP:0004368)1.89819392
105Hyperuricemia (HP:0002149)1.89819392
106Late onset (HP:0003584)1.87044667
107Abnormal hemoglobin (HP:0011902)1.86625810
108Abnormality of renal excretion (HP:0011036)1.86412591
109Bronchomalacia (HP:0002780)1.86257864
110Intrahepatic cholestasis (HP:0001406)1.86135150
111Neurofibrillary tangles (HP:0002185)1.85158754
112Hypodontia (HP:0000668)1.84819036
113Entropion (HP:0000621)1.84199007
114Abnormality of calcium-phosphate metabolism (HP:0100530)1.83145744
115Tetany (HP:0001281)1.82868799
116Hypoplasia of the uterus (HP:0000013)1.82863093
117Erythema (HP:0010783)1.81965913
118Premature loss of primary teeth (HP:0006323)1.81561146
119Hypoglycemic coma (HP:0001325)1.80111677
120Renal tubular acidosis (HP:0001947)1.79859599
121Type I transferrin isoform profile (HP:0003642)1.78587000
122Abnormal pancreas size (HP:0012094)1.78231694
123Acanthosis nigricans (HP:0000956)1.77270603
124Cheilitis (HP:0100825)1.77092753
125Renal salt wasting (HP:0000127)1.76804363
126Germ cell neoplasia (HP:0100728)1.75292140
127Abnormality of renin-angiotensin system (HP:0000847)1.75114136
128Flat acetabular roof (HP:0003180)1.73660661
129Deviation of the thumb (HP:0009603)1.73340437
130Abnormality of the nasal septum (HP:0000419)1.73209766
131Aplasia/hypoplasia of the uterus (HP:0008684)1.71737562
132Corneal erosion (HP:0200020)1.71102406
133Abnormal glucose tolerance (HP:0001952)1.69035566
134Bradycardia (HP:0001662)1.68801761
135Distal lower limb muscle weakness (HP:0009053)1.68494831
136Widely patent fontanelles and sutures (HP:0004492)1.68289978
137Conjugated hyperbilirubinemia (HP:0002908)1.66165152
138Tetraparesis (HP:0002273)1.66105515
139Absent eyelashes (HP:0000561)1.65953494
140Metaphyseal dysplasia (HP:0100255)1.65945238
141Ileus (HP:0002595)1.65846278
142Oligodontia (HP:0000677)1.65112793
143Carious teeth (HP:0000670)1.65071406
144Abnormality of the intrinsic pathway (HP:0010989)1.64967409
145Distal lower limb amyotrophy (HP:0008944)1.64452858
146Hypokalemia (HP:0002900)1.61535624
147Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.61258796
148Insulin-resistant diabetes mellitus (HP:0000831)1.59948172
149Periodontitis (HP:0000704)1.58314747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.03046161
2FRK3.92568412
3MST43.43341212
4MAP3K22.80731672
5MAP3K32.78701283
6MST1R2.67284610
7MAPK152.57490032
8LATS12.53911552
9INSRR2.39685377
10FER2.17787082
11LIMK12.12775818
12RIPK12.06601111
13MAP2K22.05061972
14NME22.02360982
15PIK3CG1.94946223
16EPHA31.94391249
17PTK61.90147722
18EPHB11.89433176
19RPS6KB21.85465433
20ERN11.74708368
21FGFR41.71940840
22MAP3K141.71754115
23MAP3K121.69021620
24PIK3CA1.64753490
25ARAF1.46449739
26SIK11.46401379
27LMTK21.30503584
28CDK81.29543853
29PIM21.26272278
30PHKG11.26204721
31PHKG21.26204721
32MAPKAPK31.23585839
33NUAK11.23561082
34STK38L1.23541894
35EPHB21.23243526
36STK241.22338797
37CHUK1.21816719
38BUB11.21419640
39WNK41.18972682
40MET1.14089676
41NLK1.10869599
42MAP3K91.09930728
43NTRK11.08586063
44EIF2AK11.08037332
45TRPM71.05781216
46TRIM281.02349605
47NME11.01995061
48VRK21.01022299
49SCYL21.00932963
50LRRK20.99854951
51TAOK30.99242399
52PBK0.97141845
53ERBB30.94347878
54STK100.94201244
55IRAK30.94010988
56PTK2B0.90926753
57FGFR30.89269162
58ABL20.86060064
59TGFBR20.85247747
60AKT30.84634956
61SIK30.83394071
62PASK0.83357228
63STK380.82272204
64TYK20.81782657
65JAK30.81389893
66MATK0.80303952
67HIPK20.79910454
68EIF2AK30.79712203
69PRKG20.78432641
70PAK40.78276602
71LATS20.77490633
72TESK10.76843020
73NEK90.76503502
74TSSK60.76079094
75ERBB20.75718091
76* PTK20.72771389
77PRKCI0.72427521
78TESK20.70455347
79FGFR20.69481196
80TGFBR10.66843372
81EEF2K0.65448098
82DYRK1B0.64680812
83MOS0.64423792
84NEK10.63245003
85PDK20.62514755
86BRSK20.61754958
87MAP3K10.61431856
88ZAK0.61240302
89MAP3K70.60868457
90RPS6KA40.60454571
91STK30.57311355
92CDK60.57264733
93ERBB40.55220838
94PDGFRB0.54855566
95STK390.53324575
96EIF2AK20.53166659
97TIE10.51949924
98FLT30.50694317
99MAP2K10.50237204
100IKBKE0.48956212
101MAP2K60.48075471
102JAK10.48009955
103MAPKAPK20.47345377
104BMX0.47292843
105BCKDK0.46681740
106ICK0.46503845
107GSK3A0.46082272
108PKN20.45774800
109MAP3K80.45723862
110IKBKB0.45190698
111TBK10.44933287
112TRIB30.44202485
113DAPK10.43038605
114JAK20.42845711
115BMPR1B0.42530398
116GRK10.42479845
117PAK30.42272049
118PRKCE0.41371353
119ROCK20.41270972
120ILK0.41011223
121BTK0.40227005
122PLK30.39946975
123BRSK10.39150625
124OXSR10.38535926
125CDC42BPA0.38220686
126ROCK10.38036369
127WNK30.37253116
128ADRBK10.37055348
129RPS6KA10.36798295
130MELK0.35847393
131BRAF0.34971216
132IRAK10.34803850
133TTN0.34233375
134RPS6KA20.34015691
135FGFR10.33213495
136CDK90.32989861
137IRAK40.32846529
138PDGFRA0.32530536
139MYLK0.31174593
140BCR0.31106603
141RET0.30624944
142DMPK0.29846926
143MTOR0.27723733
144PRKD20.26497094
145CSNK1G30.26114028
146SMG10.24040274
147TTK0.23854821
148CAMK2D0.23759835
149PNCK0.23479239
150WNK10.22034583
151TAF10.20580678
152PAK10.20245878

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.79451587
2Sulfur metabolism_Homo sapiens_hsa009202.83022295
3Proteasome_Homo sapiens_hsa030502.67335516
4Vitamin B6 metabolism_Homo sapiens_hsa007502.57674231
5Caffeine metabolism_Homo sapiens_hsa002322.20135242
6Histidine metabolism_Homo sapiens_hsa003402.04347463
7Vitamin digestion and absorption_Homo sapiens_hsa049771.99071040
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97597957
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96638074
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81911246
11ECM-receptor interaction_Homo sapiens_hsa045121.79939056
12Fatty acid elongation_Homo sapiens_hsa000621.75061258
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72035709
14Small cell lung cancer_Homo sapiens_hsa052221.71192371
15Mineral absorption_Homo sapiens_hsa049781.70942052
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69871956
17Adherens junction_Homo sapiens_hsa045201.65394245
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61428615
19Fat digestion and absorption_Homo sapiens_hsa049751.51780864
20Chemical carcinogenesis_Homo sapiens_hsa052041.50968134
21Protein digestion and absorption_Homo sapiens_hsa049741.48920601
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.47925741
23Toxoplasmosis_Homo sapiens_hsa051451.47737796
24Phenylalanine metabolism_Homo sapiens_hsa003601.46193888
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44000728
26Tight junction_Homo sapiens_hsa045301.43408043
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38290545
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32970930
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28128605
30Glutathione metabolism_Homo sapiens_hsa004801.26921668
31Bladder cancer_Homo sapiens_hsa052191.22259475
32TNF signaling pathway_Homo sapiens_hsa046681.19907961
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.19515526
34Hippo signaling pathway_Homo sapiens_hsa043901.17682920
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16508422
36Pyrimidine metabolism_Homo sapiens_hsa002401.14628780
37Starch and sucrose metabolism_Homo sapiens_hsa005001.12597242
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12147984
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11387259
40Prolactin signaling pathway_Homo sapiens_hsa049171.10555685
41Amoebiasis_Homo sapiens_hsa051461.09218619
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08493505
43Tryptophan metabolism_Homo sapiens_hsa003801.08462194
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07816751
45p53 signaling pathway_Homo sapiens_hsa041151.07553263
46Hepatitis C_Homo sapiens_hsa051601.07312925
47Folate biosynthesis_Homo sapiens_hsa007901.06966839
48Pentose phosphate pathway_Homo sapiens_hsa000301.06255196
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04759718
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04221769
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04204207
52Vibrio cholerae infection_Homo sapiens_hsa051101.03369879
53Thyroid cancer_Homo sapiens_hsa052161.03346180
54Arachidonic acid metabolism_Homo sapiens_hsa005901.01951439
55Shigellosis_Homo sapiens_hsa051311.01634449
56beta-Alanine metabolism_Homo sapiens_hsa004101.01502147
57Insulin resistance_Homo sapiens_hsa049310.98063525
58ABC transporters_Homo sapiens_hsa020100.96091629
59Antigen processing and presentation_Homo sapiens_hsa046120.95166026
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93894724
61Galactose metabolism_Homo sapiens_hsa000520.93147565
62Other glycan degradation_Homo sapiens_hsa005110.91937495
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91870418
64Linoleic acid metabolism_Homo sapiens_hsa005910.91297230
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.90846595
66Focal adhesion_Homo sapiens_hsa045100.90537848
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90511056
68Bile secretion_Homo sapiens_hsa049760.89749057
69Fatty acid degradation_Homo sapiens_hsa000710.88740405
70Proteoglycans in cancer_Homo sapiens_hsa052050.88623320
71Selenocompound metabolism_Homo sapiens_hsa004500.87752535
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86043440
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.84537157
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84207799
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83556992
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82025653
77Sphingolipid metabolism_Homo sapiens_hsa006000.81456579
78Retinol metabolism_Homo sapiens_hsa008300.80754211
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.80554159
80Basal cell carcinoma_Homo sapiens_hsa052170.79113061
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78410327
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.77382592
83Pancreatic secretion_Homo sapiens_hsa049720.77363135
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74853212
85Legionellosis_Homo sapiens_hsa051340.74550242
86Steroid biosynthesis_Homo sapiens_hsa001000.74040337
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73392206
88Hematopoietic cell lineage_Homo sapiens_hsa046400.72480068
89Endometrial cancer_Homo sapiens_hsa052130.72083481
90Renin-angiotensin system_Homo sapiens_hsa046140.70680409
91TGF-beta signaling pathway_Homo sapiens_hsa043500.70536900
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70506907
93Salmonella infection_Homo sapiens_hsa051320.69503976
94Circadian rhythm_Homo sapiens_hsa047100.68627189
95Protein export_Homo sapiens_hsa030600.68356381
96Leishmaniasis_Homo sapiens_hsa051400.68301698
97N-Glycan biosynthesis_Homo sapiens_hsa005100.67778729
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67419792
99Prostate cancer_Homo sapiens_hsa052150.67278004
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.66576637
101Thyroid hormone synthesis_Homo sapiens_hsa049180.65800416
102Influenza A_Homo sapiens_hsa051640.63653318
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63495537
104Insulin secretion_Homo sapiens_hsa049110.63363979
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59485797
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59425495
107Tyrosine metabolism_Homo sapiens_hsa003500.58716337
108Pertussis_Homo sapiens_hsa051330.58446163
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58361367
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58002680
111Salivary secretion_Homo sapiens_hsa049700.57230457
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56401210
113Fructose and mannose metabolism_Homo sapiens_hsa000510.55993139
114Pyruvate metabolism_Homo sapiens_hsa006200.55771075
115Apoptosis_Homo sapiens_hsa042100.55710173
116PPAR signaling pathway_Homo sapiens_hsa033200.55182460
117Glycerolipid metabolism_Homo sapiens_hsa005610.53710530
118RNA polymerase_Homo sapiens_hsa030200.53430854
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53065749
120Acute myeloid leukemia_Homo sapiens_hsa052210.52728428
121Pathways in cancer_Homo sapiens_hsa052000.51281903
122Endocytosis_Homo sapiens_hsa041440.51238414
123Nucleotide excision repair_Homo sapiens_hsa034200.51196738
124Glucagon signaling pathway_Homo sapiens_hsa049220.50295867
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48478823
126Metabolic pathways_Homo sapiens_hsa011000.48401910
127Lysosome_Homo sapiens_hsa041420.47636014
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46933734
129Osteoclast differentiation_Homo sapiens_hsa043800.45219494
130Rheumatoid arthritis_Homo sapiens_hsa053230.44781688
131Chronic myeloid leukemia_Homo sapiens_hsa052200.44629362
132Pancreatic cancer_Homo sapiens_hsa052120.44139045
133Basal transcription factors_Homo sapiens_hsa030220.43525831
134Biosynthesis of amino acids_Homo sapiens_hsa012300.42433058
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.42018154
136MicroRNAs in cancer_Homo sapiens_hsa052060.41655193
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41047046
138Fatty acid biosynthesis_Homo sapiens_hsa000610.39994127
139Arginine and proline metabolism_Homo sapiens_hsa003300.38429570
140Carbon metabolism_Homo sapiens_hsa012000.35529814
141Dilated cardiomyopathy_Homo sapiens_hsa054140.34293325
142Axon guidance_Homo sapiens_hsa043600.34289258
143Non-homologous end-joining_Homo sapiens_hsa034500.33862684
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30054966
145Renal cell carcinoma_Homo sapiens_hsa052110.29188693
146Purine metabolism_Homo sapiens_hsa002300.28455087
147Insulin signaling pathway_Homo sapiens_hsa049100.27563304
148One carbon pool by folate_Homo sapiens_hsa006700.26234395

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