CDCA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.70243338
2protein localization to chromosome, centromeric region (GO:0071459)5.28913315
3mitotic metaphase plate congression (GO:0007080)5.21821293
4mitotic sister chromatid segregation (GO:0000070)5.18615431
5kinetochore organization (GO:0051383)5.17520173
6mitotic chromosome condensation (GO:0007076)4.96597654
7sister chromatid segregation (GO:0000819)4.90082573
8metaphase plate congression (GO:0051310)4.72819292
9DNA unwinding involved in DNA replication (GO:0006268)4.66217686
10attachment of spindle microtubules to kinetochore (GO:0008608)4.61694011
11CENP-A containing nucleosome assembly (GO:0034080)4.60207953
12chromatin remodeling at centromere (GO:0031055)4.58872085
13kinetochore assembly (GO:0051382)4.47483596
14nuclear pore organization (GO:0006999)4.46192684
15DNA strand elongation involved in DNA replication (GO:0006271)4.45131658
16nuclear pore complex assembly (GO:0051292)4.44586097
17establishment of chromosome localization (GO:0051303)4.43973748
18meiotic chromosome segregation (GO:0045132)4.34691177
19DNA replication initiation (GO:0006270)4.25222413
20DNA strand elongation (GO:0022616)4.24631267
21telomere maintenance via semi-conservative replication (GO:0032201)4.22141809
22regulation of spindle organization (GO:0090224)4.21937308
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.17968460
24establishment of integrated proviral latency (GO:0075713)4.13622328
25DNA replication-independent nucleosome assembly (GO:0006336)4.13231305
26DNA replication-independent nucleosome organization (GO:0034724)4.13231305
27DNA replication checkpoint (GO:0000076)4.07375990
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.01599068
29mitotic nuclear envelope disassembly (GO:0007077)4.01038730
30histone exchange (GO:0043486)4.00292369
31DNA replication-dependent nucleosome organization (GO:0034723)3.99423474
32DNA replication-dependent nucleosome assembly (GO:0006335)3.99423474
33mitotic recombination (GO:0006312)3.99364898
34microtubule depolymerization (GO:0007019)3.96194639
35telomere maintenance via recombination (GO:0000722)3.88986067
36chromosome condensation (GO:0030261)3.82277629
37protein localization to chromosome (GO:0034502)3.75145297
38spindle checkpoint (GO:0031577)3.73365550
39nuclear envelope disassembly (GO:0051081)3.69750225
40membrane disassembly (GO:0030397)3.69750225
41regulation of chromosome segregation (GO:0051983)3.69447121
42chromosome segregation (GO:0007059)3.65568707
43regulation of mitotic spindle organization (GO:0060236)3.62833535
44telomere maintenance via telomere lengthening (GO:0010833)3.58700232
45mitotic sister chromatid cohesion (GO:0007064)3.57645682
46negative regulation of chromosome segregation (GO:0051985)3.57525197
47spindle assembly checkpoint (GO:0071173)3.55657723
48negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.54096751
49negative regulation of sister chromatid segregation (GO:0033046)3.54096751
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.54096751
51negative regulation of mitotic sister chromatid segregation (GO:0033048)3.54096751
52pore complex assembly (GO:0046931)3.51778953
53DNA packaging (GO:0006323)3.51367219
54DNA geometric change (GO:0032392)3.51255481
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.50598344
56DNA duplex unwinding (GO:0032508)3.50021542
57positive regulation of chromosome segregation (GO:0051984)3.49165265
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.44675975
59regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.43398163
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43192805
61mitotic spindle assembly checkpoint (GO:0007094)3.41936297
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.41518132
63protein K6-linked ubiquitination (GO:0085020)3.41239831
64DNA topological change (GO:0006265)3.41010182
65chromatin assembly or disassembly (GO:0006333)3.38872525
66DNA conformation change (GO:0071103)3.38856668
67regulation of mitotic sister chromatid separation (GO:0010965)3.38840942
68regulation of mitotic sister chromatid segregation (GO:0033047)3.38840942
69regulation of sister chromatid segregation (GO:0033045)3.38840942
70positive regulation of mitotic sister chromatid separation (GO:1901970)3.38408168
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38408168
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38408168
73mitotic spindle checkpoint (GO:0071174)3.38402636
74regulation of DNA endoreduplication (GO:0032875)3.37883747
75nucleotide-excision repair, DNA gap filling (GO:0006297)3.36970038
76ATP-dependent chromatin remodeling (GO:0043044)3.27545780
77double-strand break repair via nonhomologous end joining (GO:0006303)3.27113100
78non-recombinational repair (GO:0000726)3.27113100
79regulation of centrosome cycle (GO:0046605)3.26817348
80regulation of telomere maintenance via telomerase (GO:0032210)3.26427736
81ribosomal small subunit assembly (GO:0000028)3.24898465
82DNA synthesis involved in DNA repair (GO:0000731)3.22228637
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.22200794
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22200794
85regulation of histone H3-K9 methylation (GO:0051570)3.21369655
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17737823
87IMP biosynthetic process (GO:0006188)3.16951372
88synapsis (GO:0007129)3.16596296
89protein complex localization (GO:0031503)3.15963772
90regulation of double-strand break repair via homologous recombination (GO:0010569)3.15934119
91heterochromatin organization (GO:0070828)3.15323367
92regulation of sister chromatid cohesion (GO:0007063)3.12766391
93histone-serine phosphorylation (GO:0035404)3.11480176
94resolution of meiotic recombination intermediates (GO:0000712)3.10353340
95establishment of viral latency (GO:0019043)3.09817206
96regulation of centriole replication (GO:0046599)3.08808190
97DNA ligation (GO:0006266)3.08082043
98mitotic spindle organization (GO:0007052)3.07525551
99regulation of spindle checkpoint (GO:0090231)3.07293676
100negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.06785291
101nucleobase biosynthetic process (GO:0046112)3.05109485
102mismatch repair (GO:0006298)3.04116475
103maturation of SSU-rRNA (GO:0030490)3.03711807
104telomere maintenance (GO:0000723)3.02389792
105telomere organization (GO:0032200)3.00519210
106negative regulation of DNA-dependent DNA replication (GO:2000104)2.98539466
107negative regulation of nuclear division (GO:0051784)2.97604830
108negative regulation of cell division (GO:0051782)2.96867946
109mitotic cell cycle (GO:0000278)2.95789797
110ventricular cardiac muscle cell development (GO:0055015)2.95190099
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91228093
112chromosome organization (GO:0051276)2.90227888
113regulation of double-strand break repair (GO:2000779)2.85232070
114translesion synthesis (GO:0019985)2.81992686
115negative regulation of mitosis (GO:0045839)2.81686574
116mitotic G2/M transition checkpoint (GO:0044818)2.81113938
117formation of translation preinitiation complex (GO:0001731)2.80995293
118nuclear envelope organization (GO:0006998)2.80307542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.74444125
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.78199614
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.33722862
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.73522326
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.25413633
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74965209
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74572369
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71136679
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59846557
10* AR_21909140_ChIP-Seq_LNCAP_Human2.50087898
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.40681900
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39252124
13* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.36680611
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.31616470
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21684544
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17034108
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.15349050
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14964921
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11522531
20XRN2_22483619_ChIP-Seq_HELA_Human2.08334907
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06720827
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.04097554
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02443093
24E2F7_22180533_ChIP-Seq_HELA_Human10.5321694
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.94893593
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94448551
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86560979
28* VDR_23849224_ChIP-Seq_CD4+_Human1.82210206
29FOXP3_21729870_ChIP-Seq_TREG_Human1.77257771
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76886178
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.73240115
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70450733
33* TTF2_22483619_ChIP-Seq_HELA_Human1.67625349
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63940045
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62486985
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62175902
37* DCP1A_22483619_ChIP-Seq_HELA_Human1.59119101
38CIITA_25753668_ChIP-Seq_RAJI_Human1.54199733
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53216873
40ELK1_19687146_ChIP-ChIP_HELA_Human1.52444298
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52191640
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51221685
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50039771
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47771560
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45510247
46GABP_19822575_ChIP-Seq_HepG2_Human1.42474700
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42178249
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41622279
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41304263
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36353865
51* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35021678
52MYC_22102868_ChIP-Seq_BL_Human1.33317439
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30935741
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30666188
55* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30538228
56KDM5A_27292631_Chip-Seq_BREAST_Human1.27430574
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26534202
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23967225
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.22148896
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19489077
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.19361599
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17555289
63* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16478617
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12787448
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11837559
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10926266
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08069943
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07004878
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07004878
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07004878
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06394623
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04549804
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04402837
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03250469
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02804720
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01809643
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.01079672
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99579608
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99086611
80* MYC_18940864_ChIP-ChIP_HL60_Human0.97125732
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95171003
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94196478
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94050863
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92819973
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92091444
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91441462
87NANOG_21062744_ChIP-ChIP_HESCs_Human0.88887449
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88096434
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.87489344
90TFEB_21752829_ChIP-Seq_HELA_Human0.87436435
91VDR_21846776_ChIP-Seq_THP-1_Human0.85637128
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85336239
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81482661
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81070549
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79171303
96CHD1_26751641_Chip-Seq_LNCaP_Human0.78779615
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77872050
98* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77676490
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75710784
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.75565072
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75210639
102NANOG_16153702_ChIP-ChIP_HESCs_Human0.75113698
103SPI1_23547873_ChIP-Seq_NB4_Human0.75106302
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75023894
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74734964
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.74004899
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73500369
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73036069
109* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72716658
110EWS_26573619_Chip-Seq_HEK293_Human0.72563031
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72096398
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.71843880
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70904347
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70843716
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69777304
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.67561248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.98543680
2MP0010094_abnormal_chromosome_stability4.97728400
3MP0003111_abnormal_nucleus_morphology4.84041108
4MP0008057_abnormal_DNA_replication4.17691614
5MP0003077_abnormal_cell_cycle4.15953734
6MP0004957_abnormal_blastocyst_morpholog4.04170807
7MP0008058_abnormal_DNA_repair3.16341083
8MP0008007_abnormal_cellular_replicative2.91058425
9MP0008932_abnormal_embryonic_tissue2.70823578
10MP0009697_abnormal_copulation2.34098816
11MP0008877_abnormal_DNA_methylation2.29509512
12MP0000350_abnormal_cell_proliferation2.20724908
13MP0001730_embryonic_growth_arrest2.13683881
14MP0002396_abnormal_hematopoietic_system2.10567736
15MP0003123_paternal_imprinting2.02504244
16MP0010307_abnormal_tumor_latency1.94470649
17MP0010030_abnormal_orbit_morphology1.83066810
18MP0003786_premature_aging1.81845567
19MP0001672_abnormal_embryogenesis/_devel1.77642379
20MP0005380_embryogenesis_phenotype1.77642379
21MP0003121_genomic_imprinting1.69828442
22MP0001697_abnormal_embryo_size1.69763599
23MP0002085_abnormal_embryonic_tissue1.62170757
24MP0000566_synostosis1.61358347
25MP0010352_gastrointestinal_tract_polyps1.60512842
26MP0000490_abnormal_crypts_of1.59671699
27MP0003984_embryonic_growth_retardation1.54011371
28MP0002088_abnormal_embryonic_growth/wei1.50733542
29MP0003941_abnormal_skin_development1.49164286
30MP0002084_abnormal_developmental_patter1.47346862
31MP0002210_abnormal_sex_determination1.45920905
32MP0004808_abnormal_hematopoietic_stem1.45787816
33MP0002080_prenatal_lethality1.44855981
34MP0000313_abnormal_cell_death1.43367314
35MP0004197_abnormal_fetal_growth/weight/1.42824152
36MP0001293_anophthalmia1.42403939
37MP0002086_abnormal_extraembryonic_tissu1.40562023
38MP0001929_abnormal_gametogenesis1.36456448
39MP0003315_abnormal_perineum_morphology1.33539845
40MP0003718_maternal_effect1.33040509
41MP0006292_abnormal_olfactory_placode1.27689663
42MP0002019_abnormal_tumor_incidence1.27113794
43MP0003890_abnormal_embryonic-extraembry1.24832475
44MP0005076_abnormal_cell_differentiation1.23185894
45MP0001145_abnormal_male_reproductive1.22838170
46MP0003705_abnormal_hypodermis_morpholog1.19696628
47MP0002653_abnormal_ependyma_morphology1.18470177
48MP0003950_abnormal_plasma_membrane1.15713747
49MP0003937_abnormal_limbs/digits/tail_de1.15619263
50MP0009053_abnormal_anal_canal1.15226227
51MP0003567_abnormal_fetal_cardiomyocyte1.10083786
52MP0000653_abnormal_sex_gland1.04472953
53MP0005410_abnormal_fertilization1.00918245
54MP0000358_abnormal_cell_content/0.99253952
55MP0000703_abnormal_thymus_morphology0.98188088
56MP0000049_abnormal_middle_ear0.97973601
57MP0005397_hematopoietic_system_phenotyp0.97532547
58MP0001545_abnormal_hematopoietic_system0.97532547
59MP0002877_abnormal_melanocyte_morpholog0.96729889
60MP0004233_abnormal_muscle_weight0.96483340
61MP0006035_abnormal_mitochondrial_morpho0.94591511
62MP0002111_abnormal_tail_morphology0.93550549
63MP0000537_abnormal_urethra_morphology0.93305275
64MP0002233_abnormal_nose_morphology0.93205568
65MP0003119_abnormal_digestive_system0.92528724
66MP0003698_abnormal_male_reproductive0.92369562
67MP0005395_other_phenotype0.89034415
68MP0001286_abnormal_eye_development0.88725201
69MP0008789_abnormal_olfactory_epithelium0.87541185
70MP0001346_abnormal_lacrimal_gland0.87267078
71MP0001119_abnormal_female_reproductive0.86268768
72MP0002102_abnormal_ear_morphology0.86038323
73MP0003699_abnormal_female_reproductive0.85877366
74MP0003787_abnormal_imprinting0.85706497
75MP0002398_abnormal_bone_marrow0.84543403
76MP0002092_abnormal_eye_morphology0.83332205
77MP0009672_abnormal_birth_weight0.82746851
78MP0009379_abnormal_foot_pigmentation0.82388237
79MP0003763_abnormal_thymus_physiology0.80629832
80MP0004133_heterotaxia0.78464385
81MP0000432_abnormal_head_morphology0.78438286
82MP0009278_abnormal_bone_marrow0.78207516
83MP0003115_abnormal_respiratory_system0.78174362
84MP0002722_abnormal_immune_system0.77667347
85MP0002249_abnormal_larynx_morphology0.77549255
86MP0004264_abnormal_extraembryonic_tissu0.76885706
87MP0009703_decreased_birth_body0.75845277
88MP0005501_abnormal_skin_physiology0.75094197
89MP0002160_abnormal_reproductive_system0.73747168
90MP0009333_abnormal_splenocyte_physiolog0.72879198
91MP0000762_abnormal_tongue_morphology0.72825979
92MP0003755_abnormal_palate_morphology0.72712961
93MP0002009_preneoplasia0.72705769
94MP0005623_abnormal_meninges_morphology0.72646633
95MP0002234_abnormal_pharynx_morphology0.71685952
96MP0001915_intracranial_hemorrhage0.71570541
97MP0000689_abnormal_spleen_morphology0.71167201
98MP0003935_abnormal_craniofacial_develop0.70968262
99MP0002938_white_spotting0.70880188
100MP0000428_abnormal_craniofacial_morphol0.70329943
101MP0003385_abnormal_body_wall0.69649808
102MP0002932_abnormal_joint_morphology0.69058037
103MP0002697_abnormal_eye_size0.68776258
104MP0001299_abnormal_eye_distance/0.67527184
105MP0000858_altered_metastatic_potential0.67067791
106MP0002161_abnormal_fertility/fecundity0.65932795
107MP0002132_abnormal_respiratory_system0.65518498
108MP0005384_cellular_phenotype0.65088347
109MP0005394_taste/olfaction_phenotype0.64219083
110MP0005499_abnormal_olfactory_system0.64219083
111MP0003938_abnormal_ear_development0.64113994
112MP0010234_abnormal_vibrissa_follicle0.63671304
113MP0005023_abnormal_wound_healing0.63169987
114MP0002282_abnormal_trachea_morphology0.63035848
115MP0004185_abnormal_adipocyte_glucose0.62922593
116MP0005389_reproductive_system_phenotype0.62434202
117MP0002429_abnormal_blood_cell0.62116478
118MP0002114_abnormal_axial_skeleton0.61986092
119MP0005621_abnormal_cell_physiology0.61160438
120MP0006054_spinal_hemorrhage0.60669751
121MP0001661_extended_life_span0.58872253
122MP0003861_abnormal_nervous_system0.58797004
123MP0002925_abnormal_cardiovascular_devel0.58654016
124MP0003136_yellow_coat_color0.58003859
125MP0001529_abnormal_vocalization0.56740086
126MP0000647_abnormal_sebaceous_gland0.55194187
127MP0001881_abnormal_mammary_gland0.54912828
128MP0002095_abnormal_skin_pigmentation0.53760841
129MP0002751_abnormal_autonomic_nervous0.53541827
130MP0003186_abnormal_redox_activity0.53166361
131MP0003942_abnormal_urinary_system0.51838352

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.52833677
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.47898231
3Reticulocytopenia (HP:0001896)4.16444085
4Abnormality of chromosome stability (HP:0003220)3.87551732
5Meckel diverticulum (HP:0002245)3.87253143
6Abnormality of the ileum (HP:0001549)3.71110621
7Abnormality of the preputium (HP:0100587)3.65611653
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.64323284
9Duodenal stenosis (HP:0100867)3.38294806
10Small intestinal stenosis (HP:0012848)3.38294806
11Impulsivity (HP:0100710)3.37752177
12Cortical dysplasia (HP:0002539)3.30675235
13Ectopic kidney (HP:0000086)3.28624824
14Duplicated collecting system (HP:0000081)3.25329100
15Birth length less than 3rd percentile (HP:0003561)3.25142174
16Abnormal lung lobation (HP:0002101)3.15054881
17Patellar aplasia (HP:0006443)3.12114248
18Medulloblastoma (HP:0002885)3.11287170
19Absent radius (HP:0003974)3.08581806
20Aplasia/Hypoplasia of the patella (HP:0006498)3.01341905
21Nephroblastoma (Wilms tumor) (HP:0002667)2.99347909
22Myelodysplasia (HP:0002863)2.98657907
23Breast hypoplasia (HP:0003187)2.97675074
24Colon cancer (HP:0003003)2.95810864
25Selective tooth agenesis (HP:0001592)2.91795287
2611 pairs of ribs (HP:0000878)2.91192877
27Absent forearm bone (HP:0003953)2.88820009
28Aplasia involving forearm bones (HP:0009822)2.88820009
29Abnormality of the renal collecting system (HP:0004742)2.87802083
30Supernumerary spleens (HP:0009799)2.85777816
31Embryonal renal neoplasm (HP:0011794)2.81108694
32Abnormality of the duodenum (HP:0002246)2.80070072
33Ependymoma (HP:0002888)2.78313262
34Sloping forehead (HP:0000340)2.77955617
35Increased nuchal translucency (HP:0010880)2.76925972
36Absent thumb (HP:0009777)2.73605018
37Abnormality of the anterior horn cell (HP:0006802)2.65923709
38Degeneration of anterior horn cells (HP:0002398)2.65923709
39Carpal bone hypoplasia (HP:0001498)2.65815496
40Volvulus (HP:0002580)2.51821253
41Triphalangeal thumb (HP:0001199)2.50643197
42Abnormality of the carotid arteries (HP:0005344)2.50105735
43Clubbing of toes (HP:0100760)2.45720142
44Bone marrow hypocellularity (HP:0005528)2.44571074
45Agnosia (HP:0010524)2.42252549
46Rhabdomyosarcoma (HP:0002859)2.39741710
47Short thumb (HP:0009778)2.39621356
48Oral leukoplakia (HP:0002745)2.38979884
49Abnormal number of incisors (HP:0011064)2.38052293
50Abnormality of cells of the erythroid lineage (HP:0012130)2.36875323
51Short 4th metacarpal (HP:0010044)2.36855567
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36855567
53Abnormal number of erythroid precursors (HP:0012131)2.34000753
54Abnormality of the labia minora (HP:0012880)2.33995080
55Aplastic anemia (HP:0001915)2.31860767
56Abnormality of DNA repair (HP:0003254)2.27868043
57Tracheoesophageal fistula (HP:0002575)2.23049721
58Proximal placement of thumb (HP:0009623)2.16780970
59Deviation of the thumb (HP:0009603)2.16340823
60Missing ribs (HP:0000921)2.15748799
61Horseshoe kidney (HP:0000085)2.14114978
62Cafe-au-lait spot (HP:0000957)2.06982394
63Duplication of thumb phalanx (HP:0009942)2.05880662
64Multiple enchondromatosis (HP:0005701)2.05072522
65Atresia of the external auditory canal (HP:0000413)2.02654955
66Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97624796
67Progressive external ophthalmoplegia (HP:0000590)1.97212331
68Pallor (HP:0000980)1.96680598
69Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96446435
70Rib fusion (HP:0000902)1.96396589
71Neoplasm of the pancreas (HP:0002894)1.95612774
72Deep philtrum (HP:0002002)1.90953391
73Aplasia/Hypoplasia of the sternum (HP:0006714)1.90690345
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90575836
75Microvesicular hepatic steatosis (HP:0001414)1.90278822
76Basal cell carcinoma (HP:0002671)1.90224362
77Premature graying of hair (HP:0002216)1.89921452
78Abnormality of the septum pellucidum (HP:0007375)1.89126461
79Abdominal situs inversus (HP:0003363)1.88712329
80Abnormality of abdominal situs (HP:0011620)1.88712329
81Septo-optic dysplasia (HP:0100842)1.88154286
82Neoplasm of striated muscle (HP:0009728)1.86764954
83High pitched voice (HP:0001620)1.86508744
84Rough bone trabeculation (HP:0100670)1.85636749
85Hypoplastic pelvis (HP:0008839)1.85089967
86Neoplasm of the oral cavity (HP:0100649)1.84888618
87Facial cleft (HP:0002006)1.82018299
88Squamous cell carcinoma (HP:0002860)1.81752255
89Glioma (HP:0009733)1.80486409
90Astrocytoma (HP:0009592)1.80294670
91Abnormality of the astrocytes (HP:0100707)1.80294670
92Absent septum pellucidum (HP:0001331)1.78664029
93Overlapping toe (HP:0001845)1.77663710
94Abnormality of cochlea (HP:0000375)1.77628591
95Aplasia/hypoplasia of the humerus (HP:0006507)1.77464698
96Abnormality of glycolysis (HP:0004366)1.77339246
97Progressive muscle weakness (HP:0003323)1.77072610
98Prominent nose (HP:0000448)1.76810573
99Facial hemangioma (HP:0000329)1.74908728
100Microglossia (HP:0000171)1.74466840
101Cleft eyelid (HP:0000625)1.74308737
102Neoplasm of the colon (HP:0100273)1.74224928
103Shoulder girdle muscle weakness (HP:0003547)1.73261205
104Abnormality of pyrimidine metabolism (HP:0004353)1.71563490
105Choanal atresia (HP:0000453)1.68889650
106Aplasia/Hypoplasia of the earlobes (HP:0009906)1.68595281
107Arteriovenous malformation (HP:0100026)1.67383946
108Increased serum pyruvate (HP:0003542)1.66738036
109Abnormality of the fetal cardiovascular system (HP:0010948)1.65619987
110Abnormal umbilical cord blood vessels (HP:0011403)1.65619987
111Single umbilical artery (HP:0001195)1.65619987
112Ureteral duplication (HP:0000073)1.64772031
113Capillary hemangiomas (HP:0005306)1.64735645
114Amaurosis fugax (HP:0100576)1.64606862
115Optic nerve coloboma (HP:0000588)1.63674413
116High anterior hairline (HP:0009890)1.63467099
117Premature ovarian failure (HP:0008209)1.63267743
118Abnormality of chromosome segregation (HP:0002916)1.61932416
119Small hand (HP:0200055)1.61682140
120Abnormality of the umbilical cord (HP:0010881)1.61554514
121Macrocytic anemia (HP:0001972)1.61146107
122Supernumerary bones of the axial skeleton (HP:0009144)1.60762899
123Skull defect (HP:0001362)1.60065744
124Embryonal neoplasm (HP:0002898)1.57372578
125Ovarian neoplasm (HP:0100615)1.54828603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.23195806
2CDC74.61781723
3WEE14.04471048
4NEK23.74703311
5TTK3.14388637
6SRPK12.72683180
7CDK122.57360375
8BRSK22.56913915
9PLK12.43139885
10TLK12.14083498
11PLK42.09502394
12NEK12.07954475
13AURKB2.06445124
14EIF2AK12.06396976
15MKNK12.01216740
16ATR1.94837349
17CHEK21.89308584
18CCNB11.88725688
19PASK1.81695382
20CDK71.72885861
21STK41.71761754
22PLK31.71449950
23VRK21.70908063
24TAF11.67968252
25ACVR1B1.62836078
26BRSK11.56689138
27STK101.55505974
28ZAK1.54997103
29VRK11.54726497
30MKNK21.51406716
31CHEK11.43355107
32CDK41.42545473
33AURKA1.42036202
34DYRK31.40311244
35RPS6KB21.36921359
36MAP3K81.36075508
37MST41.25252459
38TSSK61.25139291
39RPS6KA41.20572006
40TESK21.20463315
41BRD41.17291025
42ATM1.15929110
43EEF2K1.15321928
44MELK1.13300378
45EPHA21.12300287
46EIF2AK21.11849833
47CLK11.08334772
48STK161.01996546
49CDK20.95634794
50EIF2AK30.88860144
51CDK60.88080561
52SMG10.87964779
53PAK40.87389022
54TESK10.87160158
55TRIM280.86472457
56TGFBR10.84676281
57MAP3K100.84422929
58CDK10.82391905
59PIM10.82108950
60NME20.81654374
61ERBB40.80114627
62STK30.80044400
63NUAK10.72192931
64CDK80.71009905
65MET0.67872131
66PDK20.66505234
67MST1R0.65695745
68LATS20.62471006
69FLT30.60268201
70PNCK0.60064292
71STK38L0.59295805
72CSNK2A10.59274695
73PBK0.58762420
74CSNK2A20.54862359
75PAK10.54043506
76NME10.52856858
77TNIK0.50523991
78RPS6KA50.50504193
79MAP3K90.47186992
80STK240.45805415
81BRAF0.45065896
82SCYL20.43552120
83PRKCI0.42261179
84YES10.42100107
85PRKDC0.42029743
86AKT20.39450046
87ALK0.38761191
88MTOR0.38545345
89CDK90.38122429
90CDK180.37070573
91CDK150.36480243
92CDK11A0.36097339
93RAF10.35594621
94MARK30.34375031
95MAPK140.33990898
96BTK0.33506973
97MAP4K10.33058129
98PAK20.31780634
99LATS10.31240663
100CDK30.30757630
101AKT10.30287095
102MAP2K30.29149249
103CDK140.28792272
104TEC0.27721661
105PLK20.27242503
106ERBB30.27185097
107PKN20.25882546
108LRRK20.25342414
109CSNK1D0.24884370
110BCR0.24773488
111NEK90.24622552
112CSF1R0.24029508
113CAMK1G0.23095290
114PDK30.23068826
115PDK40.23068826
116MAPK10.22884432
117GRK60.22425233
118DMPK0.22355796
119BLK0.22312556
120GSK3B0.21970495
121CSNK1E0.21930545
122IRAK40.21524349
123FGFR10.21471487
124CHUK0.20841134
125KSR10.19868251
126ARAF0.19503523
127BMPR1B0.19249866
128RPS6KB10.18736620
129RPS6KC10.16703422

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.06967444
2Mismatch repair_Homo sapiens_hsa034304.44006898
3Homologous recombination_Homo sapiens_hsa034403.59424326
4Base excision repair_Homo sapiens_hsa034103.40251951
5Cell cycle_Homo sapiens_hsa041103.27135556
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22959794
7Spliceosome_Homo sapiens_hsa030403.22919658
8Fanconi anemia pathway_Homo sapiens_hsa034603.13488293
9RNA transport_Homo sapiens_hsa030133.04034089
10Nucleotide excision repair_Homo sapiens_hsa034202.86018665
11Ribosome_Homo sapiens_hsa030102.64045771
12One carbon pool by folate_Homo sapiens_hsa006702.54493288
13Non-homologous end-joining_Homo sapiens_hsa034502.49445126
14RNA polymerase_Homo sapiens_hsa030202.46978537
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25931061
16Pyrimidine metabolism_Homo sapiens_hsa002402.15275732
17Basal transcription factors_Homo sapiens_hsa030222.13177473
18mRNA surveillance pathway_Homo sapiens_hsa030152.10289745
19RNA degradation_Homo sapiens_hsa030181.99896859
20Proteasome_Homo sapiens_hsa030501.96352571
21Systemic lupus erythematosus_Homo sapiens_hsa053221.85521680
22p53 signaling pathway_Homo sapiens_hsa041151.82336267
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36943478
24Oocyte meiosis_Homo sapiens_hsa041141.28282851
25Pyruvate metabolism_Homo sapiens_hsa006201.22508145
26Viral carcinogenesis_Homo sapiens_hsa052031.17836927
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17692704
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15042105
29Purine metabolism_Homo sapiens_hsa002301.13189836
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12439332
31Epstein-Barr virus infection_Homo sapiens_hsa051691.09939516
32Herpes simplex infection_Homo sapiens_hsa051681.07378290
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00889163
34MicroRNAs in cancer_Homo sapiens_hsa052060.99560360
35HTLV-I infection_Homo sapiens_hsa051660.93365271
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90439630
37Antigen processing and presentation_Homo sapiens_hsa046120.90066933
38Carbon metabolism_Homo sapiens_hsa012000.89760155
39Steroid biosynthesis_Homo sapiens_hsa001000.88404651
40Basal cell carcinoma_Homo sapiens_hsa052170.86414372
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84502576
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79587165
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79482168
44Vitamin B6 metabolism_Homo sapiens_hsa007500.77610192
45Small cell lung cancer_Homo sapiens_hsa052220.76655648
46Alcoholism_Homo sapiens_hsa050340.76459669
47Selenocompound metabolism_Homo sapiens_hsa004500.74177818
48Parkinsons disease_Homo sapiens_hsa050120.69525702
49Propanoate metabolism_Homo sapiens_hsa006400.68651361
50Notch signaling pathway_Homo sapiens_hsa043300.67507661
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64182289
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63716156
53Primary immunodeficiency_Homo sapiens_hsa053400.63682995
54Fatty acid elongation_Homo sapiens_hsa000620.62073622
55Sulfur relay system_Homo sapiens_hsa041220.61936668
56Hippo signaling pathway_Homo sapiens_hsa043900.60840513
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58272023
58TGF-beta signaling pathway_Homo sapiens_hsa043500.53104809
59Hedgehog signaling pathway_Homo sapiens_hsa043400.52463383
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52392638
61Legionellosis_Homo sapiens_hsa051340.52040909
62Apoptosis_Homo sapiens_hsa042100.51069378
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50387206
64Pentose phosphate pathway_Homo sapiens_hsa000300.49989753
65Thyroid cancer_Homo sapiens_hsa052160.48405940
66Lysine degradation_Homo sapiens_hsa003100.46245593
67Oxidative phosphorylation_Homo sapiens_hsa001900.45855366
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45162005
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.44588655
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43207654
71Colorectal cancer_Homo sapiens_hsa052100.42901101
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42617225
73Hepatitis B_Homo sapiens_hsa051610.40885196
74Pathways in cancer_Homo sapiens_hsa052000.40776509
75Measles_Homo sapiens_hsa051620.40754381
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.39099344
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39024133
78Bladder cancer_Homo sapiens_hsa052190.38907326
79Adherens junction_Homo sapiens_hsa045200.36039578
80Biosynthesis of amino acids_Homo sapiens_hsa012300.35939121
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.35879744
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.35398023
83Glutathione metabolism_Homo sapiens_hsa004800.35344023
84Chronic myeloid leukemia_Homo sapiens_hsa052200.34595416
85Influenza A_Homo sapiens_hsa051640.33627028
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32738413
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31230313
88Metabolic pathways_Homo sapiens_hsa011000.30519019
89Arachidonic acid metabolism_Homo sapiens_hsa005900.30161308
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29618576
91Shigellosis_Homo sapiens_hsa051310.29430495
92Wnt signaling pathway_Homo sapiens_hsa043100.29113706
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29058340
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.28694940
95Viral myocarditis_Homo sapiens_hsa054160.26534411
96N-Glycan biosynthesis_Homo sapiens_hsa005100.26491993
97Prostate cancer_Homo sapiens_hsa052150.26027793
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25925188
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25712734
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25485522
101Hematopoietic cell lineage_Homo sapiens_hsa046400.24868097
102Alzheimers disease_Homo sapiens_hsa050100.23017501
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22822319
104Huntingtons disease_Homo sapiens_hsa050160.22097209
105Arginine and proline metabolism_Homo sapiens_hsa003300.19689676
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19104810
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18993417
108Pancreatic cancer_Homo sapiens_hsa052120.18613020
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.18556741
110HIF-1 signaling pathway_Homo sapiens_hsa040660.18305684
111Fatty acid metabolism_Homo sapiens_hsa012120.18077930
112Non-small cell lung cancer_Homo sapiens_hsa052230.17704666
113Fructose and mannose metabolism_Homo sapiens_hsa000510.17169959
114Tight junction_Homo sapiens_hsa045300.16589677
115Folate biosynthesis_Homo sapiens_hsa007900.14827889
116FoxO signaling pathway_Homo sapiens_hsa040680.14758873
117Asthma_Homo sapiens_hsa053100.14021307
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13938156
119Melanoma_Homo sapiens_hsa052180.13883870
120Linoleic acid metabolism_Homo sapiens_hsa005910.13820919
121Renin-angiotensin system_Homo sapiens_hsa046140.13070174
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12238289
123Protein export_Homo sapiens_hsa030600.12230224
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.12203287
125Proteoglycans in cancer_Homo sapiens_hsa052050.11644265
126Vitamin digestion and absorption_Homo sapiens_hsa049770.11040810
127Acute myeloid leukemia_Homo sapiens_hsa052210.10887402
128Galactose metabolism_Homo sapiens_hsa000520.10592457
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10340672

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