CDC73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.60680279
2central nervous system myelination (GO:0022010)6.60680279
3nuclear pore complex assembly (GO:0051292)6.40553979
4nuclear pore organization (GO:0006999)5.61772889
5neuron cell-cell adhesion (GO:0007158)5.44726810
6mitotic sister chromatid cohesion (GO:0007064)5.09639817
7pore complex assembly (GO:0046931)4.81448969
8presynaptic membrane assembly (GO:0097105)4.77779531
9presynaptic membrane organization (GO:0097090)4.48329621
10ribosome assembly (GO:0042255)4.13969525
11regulation of centriole replication (GO:0046599)4.10055141
12long-chain fatty acid biosynthetic process (GO:0042759)4.03191961
13myelination (GO:0042552)3.92920458
14limb bud formation (GO:0060174)3.92832223
15axon ensheathment (GO:0008366)3.87803282
16ensheathment of neurons (GO:0007272)3.87803282
17neuron recognition (GO:0008038)3.73183985
18neuron remodeling (GO:0016322)3.70781022
19negative regulation of neurotransmitter transport (GO:0051589)3.68230506
20transmission of nerve impulse (GO:0019226)3.67138751
21gamma-aminobutyric acid signaling pathway (GO:0007214)3.66722337
22regulation of memory T cell differentiation (GO:0043380)3.65869616
23DNA double-strand break processing (GO:0000729)3.64198099
24righting reflex (GO:0060013)3.54578780
25regulation of timing of cell differentiation (GO:0048505)3.51575642
26fatty acid elongation (GO:0030497)3.48685533
27monoubiquitinated protein deubiquitination (GO:0035520)3.43462896
28dendritic spine morphogenesis (GO:0060997)3.42677512
29protein K6-linked ubiquitination (GO:0085020)3.41715676
30regulation of RNA export from nucleus (GO:0046831)3.37039540
31vocalization behavior (GO:0071625)3.33335246
32cerebral cortex radially oriented cell migration (GO:0021799)3.32632646
33negative regulation of neurotransmitter secretion (GO:0046929)3.31180563
34response to X-ray (GO:0010165)3.29453581
35negative regulation of NF-kappaB import into nucleus (GO:0042347)3.24531513
36negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.23228297
37negative regulation of B cell mediated immunity (GO:0002713)3.22867500
38negative regulation of immunoglobulin mediated immune response (GO:0002890)3.22867500
39ionotropic glutamate receptor signaling pathway (GO:0035235)3.21609900
40keratinocyte development (GO:0003334)3.20548884
41mitotic nuclear envelope disassembly (GO:0007077)3.19355579
42photoreceptor cell differentiation (GO:0046530)3.18945214
43eye photoreceptor cell differentiation (GO:0001754)3.18945214
44oligodendrocyte differentiation (GO:0048709)3.18917514
45rRNA methylation (GO:0031167)3.18741357
46axonal fasciculation (GO:0007413)3.17831622
47positive regulation of synapse assembly (GO:0051965)3.17280133
48ribonucleoprotein complex disassembly (GO:0032988)3.14325016
49COPII vesicle coating (GO:0048208)3.11431682
50protein localization to synapse (GO:0035418)3.11261989
51glutamate receptor signaling pathway (GO:0007215)3.11227632
52glycerophospholipid catabolic process (GO:0046475)3.10136978
53ER overload response (GO:0006983)3.08805516
54dopamine biosynthetic process (GO:0042416)3.08439959
55neuronal action potential propagation (GO:0019227)3.06734462
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06605448
57negative regulation of T-helper cell differentiation (GO:0045623)3.06605448
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.06319763
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06319763
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06319763
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.05918481
62phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.03233470
63early endosome to late endosome transport (GO:0045022)3.03206730
64postsynaptic membrane organization (GO:0001941)3.03157198
65RNA-dependent DNA replication (GO:0006278)3.01216081
66positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.00660023
67positive regulation of action potential (GO:0045760)2.99738610
68nuclear envelope disassembly (GO:0051081)2.99276795
69membrane disassembly (GO:0030397)2.99276795
70proteasome assembly (GO:0043248)2.98690877
71double-strand break repair via nonhomologous end joining (GO:0006303)2.97026472
72non-recombinational repair (GO:0000726)2.97026472
73prenylation (GO:0097354)2.95729442
74protein prenylation (GO:0018342)2.95729442
75negative regulation of execution phase of apoptosis (GO:1900118)2.93968279
76regulation of helicase activity (GO:0051095)2.93846376
77telomere maintenance via telomerase (GO:0007004)2.93798455
78cellular response to epinephrine stimulus (GO:0071872)2.93627440
79regulation of development, heterochronic (GO:0040034)2.92209768
80mitotic metaphase plate congression (GO:0007080)2.91698523
81negative regulation of Rho protein signal transduction (GO:0035024)2.90685841
82organelle disassembly (GO:1903008)2.90496922
83regulation of DNA endoreduplication (GO:0032875)2.90426074
84mitotic G2/M transition checkpoint (GO:0044818)2.90254767
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88922479
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88863552
87cytoplasmic mRNA processing body assembly (GO:0033962)2.87792253
88mitotic G2 DNA damage checkpoint (GO:0007095)2.87125046
89positive regulation of protein import into nucleus, translocation (GO:0033160)2.86516813
90regulation of centrosome cycle (GO:0046605)2.85405856
91startle response (GO:0001964)2.85336737
92purine nucleobase biosynthetic process (GO:0009113)2.85025713
93regulation of centrosome duplication (GO:0010824)2.84886572
94lateral sprouting from an epithelium (GO:0060601)2.84311050
95negative regulation of protein localization to cell surface (GO:2000009)2.83938730
96retina layer formation (GO:0010842)2.82241371
97ventricular system development (GO:0021591)2.81936977
98protein palmitoylation (GO:0018345)2.80991301
99cranial nerve development (GO:0021545)2.80968941
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80607795
101regulation of mitotic spindle checkpoint (GO:1903504)2.80607795
102response to epinephrine (GO:0071871)2.79903827
103positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.79081018
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78498798
105regulation of feeding behavior (GO:0060259)2.78250494
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77770767
107androgen receptor signaling pathway (GO:0030521)2.74208180
108iron ion import (GO:0097286)2.74033730
109histone mRNA metabolic process (GO:0008334)2.72982800
110replicative senescence (GO:0090399)2.71848280
111IMP metabolic process (GO:0046040)2.71830245
112positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.71664133
113response to nitrosative stress (GO:0051409)2.70505001
114rRNA modification (GO:0000154)2.69323581
115CENP-A containing nucleosome assembly (GO:0034080)2.69104859
116cranial nerve morphogenesis (GO:0021602)2.68140636
117mating behavior (GO:0007617)2.68103276
118regulation of transcription from RNA polymerase I promoter (GO:0006356)2.67896215
119regulation of dopamine metabolic process (GO:0042053)2.67637970
120regulation of catecholamine metabolic process (GO:0042069)2.67637970
121regulation of glutamate secretion (GO:0014048)2.67223474
122L-amino acid import (GO:0043092)2.66489266
123cilium movement (GO:0003341)2.66030163
124metaphase plate congression (GO:0051310)2.65954442
125neuron-neuron synaptic transmission (GO:0007270)2.65387685
126regulation of transforming growth factor beta2 production (GO:0032909)2.65165160
127RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65067962
128mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64380151
129import into cell (GO:0098657)2.63318983
130substantia nigra development (GO:0021762)2.62117110
131astrocyte development (GO:0014002)2.62071777
132membrane assembly (GO:0071709)2.61964218
133maturation of 5.8S rRNA (GO:0000460)2.60991851
134sister chromatid cohesion (GO:0007062)2.60241515
135nucleobase biosynthetic process (GO:0046112)2.57891134
136negative regulation of fibroblast apoptotic process (GO:2000270)2.57830974
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.57243044
138mitochondrial RNA metabolic process (GO:0000959)2.57187042
139axonemal dynein complex assembly (GO:0070286)2.57035441
140positive regulation of dendritic spine development (GO:0060999)2.56609301
141mRNA cleavage (GO:0006379)2.56465776
142short-term memory (GO:0007614)2.56304543
143reflex (GO:0060004)2.55142806
144G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54484904
145response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.53827609
146regulation of mitotic metaphase/anaphase transition (GO:0030071)2.52902602
147regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.52902602
148negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.52569549
149chromatin remodeling at centromere (GO:0031055)2.52374744
150regulation of nucleobase-containing compound transport (GO:0032239)2.50861734
151regulation of synapse assembly (GO:0051963)2.50603210
152regulation of collateral sprouting (GO:0048670)2.49907451
153neuronal ion channel clustering (GO:0045161)2.49774926
154regulation of dendritic spine development (GO:0060998)2.49517951
155folic acid-containing compound biosynthetic process (GO:0009396)2.48939480
156adult walking behavior (GO:0007628)2.48930517
157regulation of glycogen (starch) synthase activity (GO:2000465)2.48575227
158lactate metabolic process (GO:0006089)2.48249284
159mitotic spindle checkpoint (GO:0071174)2.47973780
160positive regulation of meiosis (GO:0045836)2.47714324
161spindle checkpoint (GO:0031577)2.47073481
162sister chromatid segregation (GO:0000819)2.47068991
163dendrite development (GO:0016358)2.46678433
164forebrain neuron differentiation (GO:0021879)2.46424544
165regulation of establishment of cell polarity (GO:2000114)2.45718003
166developmental pigmentation (GO:0048066)2.45577984
167spinal cord motor neuron differentiation (GO:0021522)2.45527634
168regulation of sister chromatid cohesion (GO:0007063)2.45349866
169positive regulation of chromosome segregation (GO:0051984)2.44736103
170IMP biosynthetic process (GO:0006188)2.44454925
171cellular protein complex localization (GO:0034629)2.44246448
172regulation of pigment cell differentiation (GO:0050932)2.43360372
173synaptic transmission, glutamatergic (GO:0035249)2.42868512
174histone mRNA catabolic process (GO:0071044)2.42472651
175recombinational repair (GO:0000725)2.41446776
176organ growth (GO:0035265)2.41403385
177detection of calcium ion (GO:0005513)2.41053512
178response to pheromone (GO:0019236)2.40850352
179granulocyte differentiation (GO:0030851)2.39900422
180regulation of glucokinase activity (GO:0033131)2.39847214
181regulation of hexokinase activity (GO:1903299)2.39847214
182activated T cell proliferation (GO:0050798)2.39405060
183asymmetric protein localization (GO:0008105)2.39264006
184otic vesicle formation (GO:0030916)2.39050887
185negative regulation of keratinocyte proliferation (GO:0010839)2.38852235
186NLS-bearing protein import into nucleus (GO:0006607)2.38780221
187nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.38436415
188positive regulation of cell size (GO:0045793)2.37864136
189regulation of respiratory system process (GO:0044065)2.37836047
190establishment of chromosome localization (GO:0051303)2.36965498
191regulation of mitotic sister chromatid separation (GO:0010965)2.36382953
192regulation of mitotic sister chromatid segregation (GO:0033047)2.36382953
193regulation of sister chromatid segregation (GO:0033045)2.36382953
194double-strand break repair via homologous recombination (GO:0000724)2.35824331
195DNA-dependent DNA replication (GO:0006261)2.35684442
196attachment of spindle microtubules to kinetochore (GO:0008608)2.34929100
197replication fork processing (GO:0031297)2.34474355
198UDP-N-acetylglucosamine metabolic process (GO:0006047)2.34469409
199postreplication repair (GO:0006301)2.33707989
200DNA catabolic process, exonucleolytic (GO:0000738)2.33016131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.15523424
2EZH2_22144423_ChIP-Seq_EOC_Human4.03590594
3GBX2_23144817_ChIP-Seq_PC3_Human3.62097779
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92935758
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88085210
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.73053888
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72469833
8TAF15_26573619_Chip-Seq_HEK293_Human2.70728817
9ELK1_19687146_ChIP-ChIP_HELA_Human2.65655949
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53327202
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47498189
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47422297
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41826795
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40329043
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.39155425
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.33247720
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.30584199
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.23148145
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19555797
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.18211641
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18196899
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13721618
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13721618
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13263324
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12319379
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.09209870
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08722162
28VDR_22108803_ChIP-Seq_LS180_Human2.08329005
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01032607
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99288047
31AR_21909140_ChIP-Seq_LNCAP_Human1.96541026
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96205825
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93537221
34AR_21572438_ChIP-Seq_LNCaP_Human1.92930671
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.92030221
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91624362
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.86744101
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86651830
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83503375
40FUS_26573619_Chip-Seq_HEK293_Human1.82895063
41P300_19829295_ChIP-Seq_ESCs_Human1.82572421
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79857725
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78511571
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77412512
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.77230851
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77101581
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75856927
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75369509
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74758915
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.74488873
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.73522967
52GATA1_22025678_ChIP-Seq_K562_Human1.72615004
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.72256329
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68413990
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68292766
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.67414946
57* VDR_23849224_ChIP-Seq_CD4+_Human1.66099416
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.66081333
59RNF2_27304074_Chip-Seq_NSC_Mouse1.65036965
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62563276
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62322755
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61699768
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61287793
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60259672
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.58738638
66* SMAD4_21799915_ChIP-Seq_A2780_Human1.58393319
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57311344
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56139592
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55742007
70IGF1R_20145208_ChIP-Seq_DFB_Human1.55377331
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.54840978
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54466371
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53764867
74ER_23166858_ChIP-Seq_MCF-7_Human1.52020514
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51352628
76* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50844620
77* NANOG_18555785_Chip-Seq_ESCs_Mouse1.50733501
78* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45627181
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44420208
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43042080
81REST_21632747_ChIP-Seq_MESCs_Mouse1.41418237
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41268160
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40720189
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40609021
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39841433
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.39112510
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35537587
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35059680
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.34887264
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34625103
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33063548
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32290975
93DROSHA_22980978_ChIP-Seq_HELA_Human1.32035676
94* E2F1_18555785_Chip-Seq_ESCs_Mouse1.31808950
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31668238
96* CMYC_18555785_Chip-Seq_ESCs_Mouse1.31449114
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31380268
98* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30810384
99* EZH2_27294783_Chip-Seq_NPCs_Mouse1.30181525
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28480965
101* P300_18555785_Chip-Seq_ESCs_Mouse1.27253724
102* P53_22387025_ChIP-Seq_ESCs_Mouse1.26784438
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26781150
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26773998
105STAT3_23295773_ChIP-Seq_U87_Human1.26262723
106DCP1A_22483619_ChIP-Seq_HELA_Human1.25637946
107BRD4_25478319_ChIP-Seq_HGPS_Human1.25385705
108* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25193074
109* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24221735
110TP53_16413492_ChIP-PET_HCT116_Human1.24101923
111EWS_26573619_Chip-Seq_HEK293_Human1.23566450
112RUNX2_22187159_ChIP-Seq_PCA_Human1.22588710
113STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22309205
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21529956
115WT1_19549856_ChIP-ChIP_CCG9911_Human1.21402533
116TP53_18474530_ChIP-ChIP_U2OS_Human1.20152607
117FOXP3_21729870_ChIP-Seq_TREG_Human1.19986587
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19665120
119MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19354762
120TFEB_21752829_ChIP-Seq_HELA_Human1.16756516
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16212251
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16212251
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15425318
124* STAT3_18555785_Chip-Seq_ESCs_Mouse1.15204637
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14134800
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13207335
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13130437
128* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12010006
129SMAD_19615063_ChIP-ChIP_OVARY_Human1.11896658
130P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11422018
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10820432
132* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10664499
133* TCF4_23295773_ChIP-Seq_U87_Human1.09765483
134ARNT_22903824_ChIP-Seq_MCF-7_Human1.09046105
135* TAL1_26923725_Chip-Seq_HPCs_Mouse1.08887465
136* SOX2_18555785_Chip-Seq_ESCs_Mouse1.08369238
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08300390
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08272533
139* OCT4_18555785_Chip-Seq_ESCs_Mouse1.07955584
140* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07929112
141* NMYC_18555785_Chip-Seq_ESCs_Mouse1.07408616
142ETS1_20019798_ChIP-Seq_JURKAT_Human1.07054581
143NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06643879
144AHR_22903824_ChIP-Seq_MCF-7_Human1.06536225
145RING1B_27294783_Chip-Seq_NPCs_Mouse1.06014048
146ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03906783
147ELF5_23300383_ChIP-Seq_T47D_Human1.02625752
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02335230
149* CRX_20693478_ChIP-Seq_RETINA_Mouse1.02281638
150IRF1_19129219_ChIP-ChIP_H3396_Human1.00767739
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00296692
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97989831
153IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97495881
154NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96773239
155SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96755501
156SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96755501
157ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96750200
158TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96193702
159NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96132812
160NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96132812
161NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95311126
162RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94934701
163* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94114712
164MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93023366
165CDX2_22108803_ChIP-Seq_LS180_Human0.92142885
166ELK1_22589737_ChIP-Seq_MCF10A_Human0.89344679
167* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88544423
168* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86476332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.69620933
2MP0008057_abnormal_DNA_replication4.04346288
3MP0010352_gastrointestinal_tract_polyps3.22427418
4MP0009697_abnormal_copulation3.11288161
5MP0003136_yellow_coat_color3.07644807
6MP0002009_preneoplasia3.01359119
7MP0004270_analgesia2.70471138
8MP0010094_abnormal_chromosome_stability2.62198579
9MP0001486_abnormal_startle_reflex2.60723425
10MP0004742_abnormal_vestibular_system2.52031766
11* MP0004957_abnormal_blastocyst_morpholog2.48891325
12MP0001188_hyperpigmentation2.47010858
13MP0005423_abnormal_somatic_nervous2.42794399
14MP0009745_abnormal_behavioral_response2.42732666
15MP0008058_abnormal_DNA_repair2.41655218
16MP0002102_abnormal_ear_morphology2.41077049
17MP0003111_abnormal_nucleus_morphology2.39953510
18MP0005409_darkened_coat_color2.38182554
19MP0003635_abnormal_synaptic_transmissio2.36425917
20MP0001440_abnormal_grooming_behavior2.30677018
21MP0003941_abnormal_skin_development2.27183262
22MP0008007_abnormal_cellular_replicative2.25729420
23MP0002272_abnormal_nervous_system2.25611413
24MP0000427_abnormal_hair_cycle2.25462246
25MP0002064_seizures2.24085104
26MP0000778_abnormal_nervous_system2.23655769
27MP0009046_muscle_twitch2.21638071
28MP0003693_abnormal_embryo_hatching2.21216989
29MP0000920_abnormal_myelination2.20881217
30MP0004859_abnormal_synaptic_plasticity2.14917659
31MP0006292_abnormal_olfactory_placode2.14836282
32MP0002877_abnormal_melanocyte_morpholog2.13097533
33MP0006276_abnormal_autonomic_nervous2.09027739
34MP0003077_abnormal_cell_cycle2.06783689
35MP0001529_abnormal_vocalization2.05023507
36MP0006072_abnormal_retinal_apoptosis2.03695640
37MP0001905_abnormal_dopamine_level2.02828942
38MP0002572_abnormal_emotion/affect_behav2.02528948
39MP0004142_abnormal_muscle_tone2.01433227
40MP0000569_abnormal_digit_pigmentation1.98244158
41MP0002734_abnormal_mechanical_nocicepti1.97980657
42MP0001968_abnormal_touch/_nociception1.94784444
43MP0006054_spinal_hemorrhage1.88260525
44MP0002166_altered_tumor_susceptibility1.87477995
45MP0010307_abnormal_tumor_latency1.78947101
46MP0004808_abnormal_hematopoietic_stem1.76537319
47MP0001501_abnormal_sleep_pattern1.76324237
48MP0001485_abnormal_pinna_reflex1.75911290
49MP0002063_abnormal_learning/memory/cond1.75176693
50MP0003938_abnormal_ear_development1.74778293
51MP0000566_synostosis1.69570854
52MP0003656_abnormal_erythrocyte_physiolo1.69057192
53MP0004381_abnormal_hair_follicle1.67004676
54MP0002396_abnormal_hematopoietic_system1.66397777
55* MP0002067_abnormal_sensory_capabilities1.64543601
56MP0002006_tumorigenesis1.63808990
57MP0005171_absent_coat_pigmentation1.63377803
58MP0002736_abnormal_nociception_after1.61495980
59MP0002735_abnormal_chemical_nociception1.61387225
60MP0005551_abnormal_eye_electrophysiolog1.59132419
61MP0003221_abnormal_cardiomyocyte_apopto1.57392361
62MP0000383_abnormal_hair_follicle1.55063878
63MP0004084_abnormal_cardiac_muscle1.52995413
64MP0001853_heart_inflammation1.51663340
65MP0000026_abnormal_inner_ear1.50121480
66MP0004885_abnormal_endolymph1.49679562
67MP0002557_abnormal_social/conspecific_i1.46902868
68MP0002184_abnormal_innervation1.46771355
69MP0001963_abnormal_hearing_physiology1.46384517
70MP0010234_abnormal_vibrissa_follicle1.44433965
71MP0005623_abnormal_meninges_morphology1.44001143
72MP0000631_abnormal_neuroendocrine_gland1.41957804
73MP0005451_abnormal_body_composition1.38995951
74MP0009379_abnormal_foot_pigmentation1.38370592
75MP0005645_abnormal_hypothalamus_physiol1.37625564
76MP0001970_abnormal_pain_threshold1.37474260
77MP0003786_premature_aging1.35266929
78MP0003984_embryonic_growth_retardation1.35158946
79MP0002752_abnormal_somatic_nervous1.33603078
80MP0003690_abnormal_glial_cell1.33581943
81MP0002882_abnormal_neuron_morphology1.33336953
82MP0002088_abnormal_embryonic_growth/wei1.32959115
83MP0003943_abnormal_hepatobiliary_system1.28364823
84* MP0008932_abnormal_embryonic_tissue1.27796762
85* MP0000350_abnormal_cell_proliferation1.26511767
86MP0005380_embryogenesis_phenotype1.24889233
87MP0001672_abnormal_embryogenesis/_devel1.24889233
88MP0002733_abnormal_thermal_nociception1.24580969
89MP0010678_abnormal_skin_adnexa1.20246157
90MP0003937_abnormal_limbs/digits/tail_de1.19363803
91MP0005076_abnormal_cell_differentiation1.19229238
92MP0001915_intracranial_hemorrhage1.18505635
93MP0000955_abnormal_spinal_cord1.17903503
94MP0000627_abnormal_mammary_gland1.17654236
95MP0003567_abnormal_fetal_cardiomyocyte1.17236166
96MP0003950_abnormal_plasma_membrane1.16572048
97MP0001730_embryonic_growth_arrest1.15375073
98MP0004145_abnormal_muscle_electrophysio1.14820214
99MP0005386_behavior/neurological_phenoty1.14755047
100MP0004924_abnormal_behavior1.14755047
101MP0003186_abnormal_redox_activity1.14506106
102MP0003634_abnormal_glial_cell1.13913976
103MP0002229_neurodegeneration1.13687614
104MP0000762_abnormal_tongue_morphology1.13602949
105MP0009250_abnormal_appendicular_skeleto1.11537146
106* MP0001697_abnormal_embryo_size1.11139305
107MP0005248_abnormal_Harderian_gland1.10839747
108MP0003718_maternal_effect1.10822057
109MP0005253_abnormal_eye_physiology1.09686255
110MP0002282_abnormal_trachea_morphology1.08789420
111MP0001216_abnormal_epidermal_layer1.08526807
112MP0002277_abnormal_respiratory_mucosa1.06749980
113* MP0002066_abnormal_motor_capabilities/c1.05358879
114MP0000049_abnormal_middle_ear1.04779411
115MP0002249_abnormal_larynx_morphology1.03601459
116MP0005646_abnormal_pituitary_gland1.03440300
117MP0005410_abnormal_fertilization1.01250535
118MP0002152_abnormal_brain_morphology0.98312436
119MP0003890_abnormal_embryonic-extraembry0.97001167
120MP0004215_abnormal_myocardial_fiber0.96940843
121MP0001984_abnormal_olfaction0.95944713
122* MP0002086_abnormal_extraembryonic_tissu0.95756588
123MP0004197_abnormal_fetal_growth/weight/0.93038714
124MP0004233_abnormal_muscle_weight0.92944410
125MP0008877_abnormal_DNA_methylation0.92916997
126MP0004264_abnormal_extraembryonic_tissu0.92750124
127MP0001346_abnormal_lacrimal_gland0.91540576
128MP0005195_abnormal_posterior_eye0.89853314
129MP0001502_abnormal_circadian_rhythm0.89595923
130MP0003329_amyloid_beta_deposits0.88763294
131MP0003566_abnormal_cell_adhesion0.88368298
132MP0004133_heterotaxia0.87029754
133MP0005621_abnormal_cell_physiology0.86618622
134MP0002060_abnormal_skin_morphology0.85206405
135MP0001661_extended_life_span0.84424919
136MP0008569_lethality_at_weaning0.84424792
137MP0001191_abnormal_skin_condition0.84067264
138MP0002254_reproductive_system_inflammat0.83759487
139MP0003122_maternal_imprinting0.83243986
140MP0001299_abnormal_eye_distance/0.83010459
141MP0000377_abnormal_hair_follicle0.80901819
142MP0002234_abnormal_pharynx_morphology0.80739819
143MP0002084_abnormal_developmental_patter0.80728369
144MP0001881_abnormal_mammary_gland0.80677434
145MP0000647_abnormal_sebaceous_gland0.80603570
146MP0003195_calcinosis0.80485747
147MP0003828_pulmonary_edema0.80479631
148MP0002090_abnormal_vision0.80324557
149MP0002098_abnormal_vibrissa_morphology0.79690767
150* MP0002080_prenatal_lethality0.78859954
151MP0002938_white_spotting0.78399863
152MP0005187_abnormal_penis_morphology0.78271004
153MP0002796_impaired_skin_barrier0.77155836
154MP0000358_abnormal_cell_content/0.76181033
155MP0001664_abnormal_digestion0.76110919
156MP0003787_abnormal_imprinting0.75831943
157MP0003632_abnormal_nervous_system0.75627370
158MP0005384_cellular_phenotype0.74319754
159MP0000428_abnormal_craniofacial_morphol0.74145446
160MP0001243_abnormal_dermal_layer0.74103881
161MP0003448_altered_tumor_morphology0.73934287
162MP0003868_abnormal_feces_composition0.73260786
163MP0000371_diluted_coat_color0.73222144
164MP0003936_abnormal_reproductive_system0.73052251
165MP0005408_hypopigmentation0.72820770
166MP0001293_anophthalmia0.72176680
167* MP0003861_abnormal_nervous_system0.71633085
168MP0004272_abnormal_basement_membrane0.71517391
169MP0005395_other_phenotype0.70940435
170MP0001764_abnormal_homeostasis0.70887797
171MP0003385_abnormal_body_wall0.70681173
172MP0003453_abnormal_keratinocyte_physiol0.70152881
173MP0002751_abnormal_autonomic_nervous0.69698287
174MP0002177_abnormal_outer_ear0.69088333
175MP0005501_abnormal_skin_physiology0.67926473
176MP0001177_atelectasis0.67755331
177MP0001286_abnormal_eye_development0.67609475
178MP0002085_abnormal_embryonic_tissue0.67491725
179* MP0000313_abnormal_cell_death0.67158385
180MP0003755_abnormal_palate_morphology0.66824839
181MP0002163_abnormal_gland_morphology0.65997866
182MP0008438_abnormal_cutaneous_collagen0.65795244
183MP0002638_abnormal_pupillary_reflex0.64083614
184MP0002233_abnormal_nose_morphology0.63720005
185MP0003631_nervous_system_phenotype0.63472801
186MP0001879_abnormal_lymphatic_vessel0.63318599
187MP0002019_abnormal_tumor_incidence0.63289259
188MP0003300_gastrointestinal_ulcer0.62891948
189MP0004085_abnormal_heartbeat0.61977053
190MP0010630_abnormal_cardiac_muscle0.61827270
191MP0002837_dystrophic_cardiac_calcinosis0.61787541
192MP0003763_abnormal_thymus_physiology0.60490083

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.66393720
2Upper limb muscle weakness (HP:0003484)4.60753110
3Absent/shortened dynein arms (HP:0200106)4.57874726
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.57874726
5Papillary thyroid carcinoma (HP:0002895)4.44715842
6Abnormal ciliary motility (HP:0012262)4.34263235
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.96639434
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.96639434
9Abnormal respiratory motile cilium physiology (HP:0012261)3.92880698
10Parakeratosis (HP:0001036)3.74691554
11Acute myeloid leukemia (HP:0004808)3.74342014
12Abnormal respiratory epithelium morphology (HP:0012253)3.63103348
13Abnormal respiratory motile cilium morphology (HP:0005938)3.63103348
14Thyroid carcinoma (HP:0002890)3.56572139
15Focal motor seizures (HP:0011153)3.35304278
16Autoamputation (HP:0001218)3.24862659
17Osteolytic defects of the phalanges of the hand (HP:0009771)3.23959544
18Osteolytic defects of the hand bones (HP:0009699)3.23959544
19Volvulus (HP:0002580)3.22405508
20Abnormality of methionine metabolism (HP:0010901)3.15690931
21Neurofibrillary tangles (HP:0002185)3.13406238
22Sensory axonal neuropathy (HP:0003390)3.01670661
23Atelectasis (HP:0100750)2.91072376
24Abnormality of chromosome stability (HP:0003220)2.81632204
25Curly hair (HP:0002212)2.81303486
26Atonic seizures (HP:0010819)2.81269863
27Breast carcinoma (HP:0003002)2.78221579
28Abnormality of the corticospinal tract (HP:0002492)2.72722429
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.67648091
30Focal seizures (HP:0007359)2.67627543
31Hyperventilation (HP:0002883)2.62373011
32Chin dimple (HP:0010751)2.62233077
33Deep philtrum (HP:0002002)2.61815887
34Abnormality of secondary sexual hair (HP:0009888)2.60296522
35Abnormality of the axillary hair (HP:0100134)2.60296522
36Cerebral inclusion bodies (HP:0100314)2.59345295
37Febrile seizures (HP:0002373)2.58715063
38Adrenal hypoplasia (HP:0000835)2.57727143
39Septo-optic dysplasia (HP:0100842)2.56131536
40Broad-based gait (HP:0002136)2.51601076
41Short middle phalanx of the 5th finger (HP:0004220)2.49394706
42Increased hepatocellular lipid droplets (HP:0006565)2.48048195
43Abnormality of alanine metabolism (HP:0010916)2.45934230
44Hyperalaninemia (HP:0003348)2.45934230
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45934230
46Peripheral hypomyelination (HP:0007182)2.44932068
47Cystic hygroma (HP:0000476)2.44881690
48Cupped ear (HP:0000378)2.42602341
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38778287
50Chromsome breakage (HP:0040012)2.34502847
51Biliary tract neoplasm (HP:0100574)2.27509040
52Aplasia cutis congenita (HP:0001057)2.27162066
53T lymphocytopenia (HP:0005403)2.26506908
54Neuroendocrine neoplasm (HP:0100634)2.25589872
55Concave nail (HP:0001598)2.25391779
56Congenital stationary night blindness (HP:0007642)2.25197308
57* Nephroblastoma (Wilms tumor) (HP:0002667)2.25122950
58Ovarian neoplasm (HP:0100615)2.25101915
59Congenital malformation of the right heart (HP:0011723)2.22980776
60Double outlet right ventricle (HP:0001719)2.22980776
61Medulloblastoma (HP:0002885)2.22632814
62Rhinitis (HP:0012384)2.21735260
63* Embryonal renal neoplasm (HP:0011794)2.21276101
64Abnormal auditory evoked potentials (HP:0006958)2.21036741
65Absent septum pellucidum (HP:0001331)2.20658489
66Absent speech (HP:0001344)2.19594348
67Hemiparesis (HP:0001269)2.19202422
68Epileptic encephalopathy (HP:0200134)2.18995371
69Lipid accumulation in hepatocytes (HP:0006561)2.17187977
70Pheochromocytoma (HP:0002666)2.16870216
71Alacrima (HP:0000522)2.16266055
72Overfolded helix (HP:0000396)2.14489452
73Excessive salivation (HP:0003781)2.14435333
74Drooling (HP:0002307)2.14435333
75Birth length less than 3rd percentile (HP:0003561)2.11626637
76Submucous cleft hard palate (HP:0000176)2.11193124
77Rhabdomyosarcoma (HP:0002859)2.10942565
78Autoimmune hemolytic anemia (HP:0001890)2.09873815
79Abnormality of T cell number (HP:0011839)2.08953702
80Neoplasm of the small intestine (HP:0100833)2.07273098
81Nephronophthisis (HP:0000090)2.06979416
82Hypoplastic labia majora (HP:0000059)2.06297377
83Retinal dysplasia (HP:0007973)2.05842667
84Myelodysplasia (HP:0002863)2.05316487
85Meningioma (HP:0002858)2.04824416
86Abnormality of the septum pellucidum (HP:0007375)2.04003223
87Esotropia (HP:0000565)2.02512240
88Abnormality of binocular vision (HP:0011514)2.02296721
89Diplopia (HP:0000651)2.02296721
90Duplicated collecting system (HP:0000081)2.01986459
91Onion bulb formation (HP:0003383)2.01646328
92Genital tract atresia (HP:0001827)2.01352038
93Fair hair (HP:0002286)2.00923109
94Dysmetria (HP:0001310)2.00560906
95Dialeptic seizures (HP:0011146)2.00352707
96Decreased lacrimation (HP:0000633)2.00191498
97Tubulointerstitial nephritis (HP:0001970)2.00130229
98Prominent nose (HP:0000448)1.99928362
99Partial agenesis of the corpus callosum (HP:0001338)1.99709962
100Transitional cell carcinoma of the bladder (HP:0006740)1.99263463
101Hyperthyroidism (HP:0000836)1.98941047
102Metabolic alkalosis (HP:0200114)1.98751039
103Cerebellar dysplasia (HP:0007033)1.98485009
104Anomalous pulmonary venous return (HP:0010772)1.97367315
105Humeroradial synostosis (HP:0003041)1.97167954
106Synostosis involving the elbow (HP:0003938)1.97167954
107Gonadotropin excess (HP:0000837)1.95465017
108Progressive cerebellar ataxia (HP:0002073)1.95175041
109Hypophosphatemic rickets (HP:0004912)1.93420515
110Mixed hearing impairment (HP:0000410)1.93029088
111Uterine neoplasm (HP:0010784)1.92820282
112Vaginal atresia (HP:0000148)1.92806777
113White forelock (HP:0002211)1.92647533
114Generalized tonic-clonic seizures (HP:0002069)1.91169580
115Gastroesophageal reflux (HP:0002020)1.89204854
116Bladder neoplasm (HP:0009725)1.89128399
117Bladder carcinoma (HP:0002862)1.89128399
118Neoplasm of the adrenal gland (HP:0100631)1.88740242
119Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88372982
120Degeneration of anterior horn cells (HP:0002398)1.88145238
121Abnormality of the anterior horn cell (HP:0006802)1.88145238
122Asplenia (HP:0001746)1.87444836
123Neoplasm of the peripheral nervous system (HP:0100007)1.86993970
124Widely spaced teeth (HP:0000687)1.86840382
125Myelomeningocele (HP:0002475)1.86198912
126Increased serum pyruvate (HP:0003542)1.85811566
127Spastic gait (HP:0002064)1.85371040
128Abnormally folded helix (HP:0008544)1.84797087
129Meckel diverticulum (HP:0002245)1.84397622
130Abnormal biliary tract morphology (HP:0012440)1.83032726
131Hypoplastic pelvis (HP:0008839)1.82943789
132Absence seizures (HP:0002121)1.82891652
133Dyschromatopsia (HP:0007641)1.82803969
134Low anterior hairline (HP:0000294)1.82732778
135Abnormality of the fetal cardiovascular system (HP:0010948)1.82661840
136Abnormal umbilical cord blood vessels (HP:0011403)1.82661840
137Single umbilical artery (HP:0001195)1.82661840
138Pelvic girdle muscle weakness (HP:0003749)1.81720306
139Abnormality of the ileum (HP:0001549)1.81085841
140Gait imbalance (HP:0002141)1.79637143
141Prostate neoplasm (HP:0100787)1.79379376
142Aplasia involving bones of the extremities (HP:0009825)1.79041307
143Aplasia involving bones of the upper limbs (HP:0009823)1.79041307
144Aplasia of the phalanges of the hand (HP:0009802)1.79041307
145Decreased central vision (HP:0007663)1.78929368
146Thickened helices (HP:0000391)1.78514040
147Medial flaring of the eyebrow (HP:0010747)1.78292430
148Abnormal lung lobation (HP:0002101)1.78146915
149Abnormality of the labia majora (HP:0012881)1.78020312
150Abnormality of salivation (HP:0100755)1.77866325
151Subacute progressive viral hepatitis (HP:0006572)1.77534975
152Gaze-evoked nystagmus (HP:0000640)1.77119819
153Sloping forehead (HP:0000340)1.77035938
154Neoplasm of the adrenal cortex (HP:0100641)1.76787812
155Patchy hypopigmentation of hair (HP:0011365)1.76158013
156Abnormality of the hip-girdle musculature (HP:0001445)1.76009847
157Abnormality of the musculature of the pelvis (HP:0001469)1.76009847
158Duplication of thumb phalanx (HP:0009942)1.75905078
159Depressed nasal tip (HP:0000437)1.75849927
160Aplasia/Hypoplasia of the spleen (HP:0010451)1.75559740
161Abnormality of the renal medulla (HP:0100957)1.75429268
162Exotropia (HP:0000577)1.75413914
163Male pseudohermaphroditism (HP:0000037)1.75377635
164Nasolacrimal duct obstruction (HP:0000579)1.74512466
165Anophthalmia (HP:0000528)1.73434215
166Intrahepatic cholestasis (HP:0001406)1.73283403
167Neoplasm of the rectum (HP:0100743)1.72706473
168Cutaneous melanoma (HP:0012056)1.72633530
169Confusion (HP:0001289)1.71777410
170Long nose (HP:0003189)1.71080773
171Insidious onset (HP:0003587)1.70739200
172Termporal pattern (HP:0011008)1.70739200
173Uterine leiomyosarcoma (HP:0002891)1.70088994
174Leiomyosarcoma (HP:0100243)1.70088994
175Homocystinuria (HP:0002156)1.68633118
176Abnormality of homocysteine metabolism (HP:0010919)1.68633118
177Abnormality of serum amino acid levels (HP:0003112)1.67147292
178Abnormality of the preputium (HP:0100587)1.66683357
179Ectopic kidney (HP:0000086)1.64755932
180Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.63232837
181Aplasia/Hypoplasia of the uvula (HP:0010293)1.62832739
182Overlapping toe (HP:0001845)1.62683799
183Ectropion (HP:0000656)1.62249069
184Duodenal stenosis (HP:0100867)1.60700517
185Small intestinal stenosis (HP:0012848)1.60700517
186Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.60163700
187Freckling (HP:0001480)1.59628845
188* Neoplasm of the thyroid gland (HP:0100031)1.59402679
189Abnormality of the pons (HP:0007361)1.58163204
190Fatigue (HP:0012378)1.58022084
191Poor speech (HP:0002465)1.58017471
192Spinal muscular atrophy (HP:0007269)1.57553263
193Cone-rod dystrophy (HP:0000548)1.56208035
194Pulmonic stenosis (HP:0001642)1.55777741
195Abnormality of glycolysis (HP:0004366)1.55559978
196Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55099933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK25.08021895
2CASK3.79166919
3TNIK3.66995756
4STK393.57938845
5EIF2AK33.40868308
6PNCK3.31789477
7WEE13.25991080
8SRPK12.86615415
9EIF2AK12.82472726
10OXSR12.64546076
11NTRK32.53239922
12NEK92.44332371
13GRK12.36194933
14TAF12.35563289
15SCYL22.25140381
16TSSK62.12488624
17PKN12.11060426
18STK162.07850289
19NEK62.01609565
20EPHA41.92170715
21FGR1.78442354
22LATS11.72098207
23BCR1.70996157
24STK31.68094532
25FRK1.62076631
26BLK1.60923703
27STK38L1.56854507
28MARK11.54488537
29ERBB31.54401959
30MAP3K41.51585189
31BRSK11.51523157
32PIK3CA1.51187450
33PLK31.48731868
34BUB11.48004684
35MAPK131.45545196
36WNK41.41419772
37BRD41.37346461
38MUSK1.35733768
39GRK71.35521420
40AKT31.35422681
41MAPK151.32828808
42TTK1.31320105
43BMPR1B1.31004593
44NEK11.24093377
45MST41.23667844
46MAP2K71.23426499
47FES1.22679742
48UHMK11.20103149
49INSRR1.19906273
50TRIM281.18722436
51NTRK21.15298087
52IRAK21.13061284
53ROCK21.12876059
54VRK21.12626748
55WNK11.11276617
56NME11.10040629
57CAMK2B1.09830268
58PRKCE1.09629190
59ADRBK21.07134646
60CDC71.06553020
61EPHB11.05055033
62CAMK2A1.04896945
63RIPK41.03265823
64PLK41.02676896
65MKNK21.00566095
66IRAK11.00186408
67CSNK1A1L0.99731262
68MAP3K120.98885120
69MAPKAPK50.97261866
70STK100.95829104
71TEC0.94155163
72CDK190.93723114
73FGFR20.93637849
74ACVR1B0.93492007
75MELK0.93287377
76NTRK10.92811605
77DYRK30.91366592
78CDK60.91139824
79CSNK1G30.90435179
80MAP3K90.89852104
81CDK30.88380236
82CAMK2D0.87585057
83FER0.86262585
84BMPR20.86146706
85NUAK10.85969496
86STK240.85082375
87CAMK1G0.84569130
88PLK20.83539642
89PBK0.82793604
90MAP3K130.79194674
91TGFBR10.77858063
92PRKCQ0.77763649
93MARK20.77707447
94TRPM70.76752880
95GRK50.76426238
96CSNK1G10.75862688
97CSNK1G20.75143781
98PIK3CG0.74600205
99YES10.72810275
100DYRK20.72639132
101CLK10.71644347
102PLK10.71357799
103TNK20.70078026
104MET0.69880132
105NLK0.68982742
106PRKG10.68589017
107CDK50.68432577
108ADRBK10.67390938
109CDK120.67220151
110MAP3K140.65891446
111VRK10.65756216
112SIK20.64462444
113ATM0.64415427
114PRKD20.64216880
115CAMK2G0.61451163
116DYRK1A0.60996559
117RPS6KA40.60942984
118PAK30.60448698
119CDK70.60221199
120PHKG10.60085964
121PHKG20.60085964
122PRPF4B0.58966735
123DMPK0.58675595
124ATR0.56300665
125STK110.55814574
126PRKCG0.54411903
127FGFR10.53893593
128EPHB20.53862863
129SGK10.53791408
130MKNK10.53700983
131PAK40.53126382
132PAK60.53006018
133CHEK10.51910805
134PRKACA0.51784088
135CHEK20.51681764
136FLT30.51307390
137WNK30.50944641
138EIF2AK20.50578241
139SGK4940.49822024
140SGK2230.49822024
141TXK0.49349787
142ZAK0.49347822
143MAP2K40.49336794
144PDK20.48097887
145MAP3K50.47712913
146FYN0.47569410
147TIE10.47166498
148JAK30.46903805
149MAP3K70.46891550
150MAP3K100.46752757
151PINK10.45831630
152CSNK1E0.44830703
153MINK10.43719299
154AURKB0.43538829
155PTK2B0.43272907
156MYLK0.42682426
157CDK40.42262506
158CSNK1D0.40834059
159JAK10.40188234
160TAOK30.39618807
161OBSCN0.39069610
162ICK0.38796542
163ERBB40.37765023
164EGFR0.37100897
165RPS6KB20.37000549
166CSNK1A10.36917555
167PDGFRB0.36030407
168CCNB10.33979678
169CDK80.33586134
170CHUK0.32156275
171CAMK1D0.31914378

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80682749
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61050938
3Phototransduction_Homo sapiens_hsa047442.86286687
4RNA transport_Homo sapiens_hsa030132.75007766
5Proteasome_Homo sapiens_hsa030502.72473107
6Oxidative phosphorylation_Homo sapiens_hsa001902.50936239
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44988832
8Cell cycle_Homo sapiens_hsa041102.35176801
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33610541
10Basal transcription factors_Homo sapiens_hsa030222.31851792
11Homologous recombination_Homo sapiens_hsa034402.30302890
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30273346
13Serotonergic synapse_Homo sapiens_hsa047262.23241416
14RNA degradation_Homo sapiens_hsa030182.15179614
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.12543974
16Propanoate metabolism_Homo sapiens_hsa006402.10892731
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.09670808
18Glutamatergic synapse_Homo sapiens_hsa047242.08536305
19Taste transduction_Homo sapiens_hsa047422.08136742
20Morphine addiction_Homo sapiens_hsa050322.02226580
21Mismatch repair_Homo sapiens_hsa034302.01715525
22Ether lipid metabolism_Homo sapiens_hsa005651.98625263
23Spliceosome_Homo sapiens_hsa030401.97302184
24GABAergic synapse_Homo sapiens_hsa047271.97145692
25Nucleotide excision repair_Homo sapiens_hsa034201.92811266
26Axon guidance_Homo sapiens_hsa043601.91306847
27RNA polymerase_Homo sapiens_hsa030201.89112113
28Fatty acid elongation_Homo sapiens_hsa000621.87447719
29One carbon pool by folate_Homo sapiens_hsa006701.84945023
30Alzheimers disease_Homo sapiens_hsa050101.80223058
31mRNA surveillance pathway_Homo sapiens_hsa030151.78525316
32DNA replication_Homo sapiens_hsa030301.76303694
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.74517869
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71516049
35Thyroid cancer_Homo sapiens_hsa052161.70344046
36Collecting duct acid secretion_Homo sapiens_hsa049661.64556199
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64247396
38p53 signaling pathway_Homo sapiens_hsa041151.64084219
39Amphetamine addiction_Homo sapiens_hsa050311.63152051
40Parkinsons disease_Homo sapiens_hsa050121.61674292
41Steroid biosynthesis_Homo sapiens_hsa001001.61541794
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59340033
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58675384
44Long-term depression_Homo sapiens_hsa047301.57374080
45Sphingolipid metabolism_Homo sapiens_hsa006001.53659903
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52309995
47Cardiac muscle contraction_Homo sapiens_hsa042601.52034903
48Selenocompound metabolism_Homo sapiens_hsa004501.50727322
49Salivary secretion_Homo sapiens_hsa049701.42894940
50Cocaine addiction_Homo sapiens_hsa050301.40450445
51Measles_Homo sapiens_hsa051621.39264449
52Adherens junction_Homo sapiens_hsa045201.39034671
53Dopaminergic synapse_Homo sapiens_hsa047281.37302526
54Renin secretion_Homo sapiens_hsa049241.36453612
55Legionellosis_Homo sapiens_hsa051341.33682659
56Circadian entrainment_Homo sapiens_hsa047131.32759760
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30941422
58Gastric acid secretion_Homo sapiens_hsa049711.28164100
59Calcium signaling pathway_Homo sapiens_hsa040201.25614180
60Long-term potentiation_Homo sapiens_hsa047201.23054355
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20949558
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19666796
63Regulation of autophagy_Homo sapiens_hsa041401.19230105
64TGF-beta signaling pathway_Homo sapiens_hsa043501.19128836
65Huntingtons disease_Homo sapiens_hsa050161.17194407
66Pyrimidine metabolism_Homo sapiens_hsa002401.15787570
67Small cell lung cancer_Homo sapiens_hsa052221.13543154
68MicroRNAs in cancer_Homo sapiens_hsa052061.13330239
69Prostate cancer_Homo sapiens_hsa052151.12894168
70Cholinergic synapse_Homo sapiens_hsa047251.12072797
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.10272851
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08102616
73Circadian rhythm_Homo sapiens_hsa047101.06141920
74Oxytocin signaling pathway_Homo sapiens_hsa049211.00565460
75Linoleic acid metabolism_Homo sapiens_hsa005910.99459073
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.97823771
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.97677943
78Synaptic vesicle cycle_Homo sapiens_hsa047210.96543778
79Base excision repair_Homo sapiens_hsa034100.92062782
80Fatty acid biosynthesis_Homo sapiens_hsa000610.91312972
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91228552
82Viral carcinogenesis_Homo sapiens_hsa052030.91145857
83Herpes simplex infection_Homo sapiens_hsa051680.90360369
84Insulin secretion_Homo sapiens_hsa049110.89111683
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88891166
86Olfactory transduction_Homo sapiens_hsa047400.88405894
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87411274
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87162203
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86870492
90Purine metabolism_Homo sapiens_hsa002300.86530781
91Dorso-ventral axis formation_Homo sapiens_hsa043200.85636575
92Hepatitis B_Homo sapiens_hsa051610.85598360
93Wnt signaling pathway_Homo sapiens_hsa043100.85127625
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84570060
95Rheumatoid arthritis_Homo sapiens_hsa053230.83449944
96cAMP signaling pathway_Homo sapiens_hsa040240.82806699
97Lysine degradation_Homo sapiens_hsa003100.81901472
98Autoimmune thyroid disease_Homo sapiens_hsa053200.81662969
99Ras signaling pathway_Homo sapiens_hsa040140.80445576
100Pancreatic secretion_Homo sapiens_hsa049720.79996037
101Ovarian steroidogenesis_Homo sapiens_hsa049130.79423422
102Epstein-Barr virus infection_Homo sapiens_hsa051690.78684530
103Chronic myeloid leukemia_Homo sapiens_hsa052200.78336866
104Butanoate metabolism_Homo sapiens_hsa006500.77500223
105Hedgehog signaling pathway_Homo sapiens_hsa043400.76657904
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75580483
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.73994087
108Pancreatic cancer_Homo sapiens_hsa052120.73662209
109Melanogenesis_Homo sapiens_hsa049160.72344226
110Vibrio cholerae infection_Homo sapiens_hsa051100.71602330
111ErbB signaling pathway_Homo sapiens_hsa040120.70602746
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70332968
113Sulfur metabolism_Homo sapiens_hsa009200.70295831
114Choline metabolism in cancer_Homo sapiens_hsa052310.69245942
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68786820
116Protein export_Homo sapiens_hsa030600.67873419
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67748800
118Pyruvate metabolism_Homo sapiens_hsa006200.66112532
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64536422
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63741173
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.63519151
122Non-homologous end-joining_Homo sapiens_hsa034500.62911584
123GnRH signaling pathway_Homo sapiens_hsa049120.61746608
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61710558
125TNF signaling pathway_Homo sapiens_hsa046680.61563656
126Gap junction_Homo sapiens_hsa045400.61197293
127FoxO signaling pathway_Homo sapiens_hsa040680.60806652
128MAPK signaling pathway_Homo sapiens_hsa040100.60237000
129Arachidonic acid metabolism_Homo sapiens_hsa005900.59602626
130ECM-receptor interaction_Homo sapiens_hsa045120.59264915
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59120208
132Proteoglycans in cancer_Homo sapiens_hsa052050.58873157
133African trypanosomiasis_Homo sapiens_hsa051430.57880152
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.57703759
135Dilated cardiomyopathy_Homo sapiens_hsa054140.56304257
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56217877
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55816737
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55433007
139beta-Alanine metabolism_Homo sapiens_hsa004100.53632474
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53594224
141Melanoma_Homo sapiens_hsa052180.53273147
142Bladder cancer_Homo sapiens_hsa052190.52682085
143Inositol phosphate metabolism_Homo sapiens_hsa005620.52465249
144Renal cell carcinoma_Homo sapiens_hsa052110.52016871
145Tight junction_Homo sapiens_hsa045300.51762046
146Basal cell carcinoma_Homo sapiens_hsa052170.49982294
147Histidine metabolism_Homo sapiens_hsa003400.49702548
148Mineral absorption_Homo sapiens_hsa049780.49086539
149Influenza A_Homo sapiens_hsa051640.48363391
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48306002
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48011451
152Peroxisome_Homo sapiens_hsa041460.47123272
153Hepatitis C_Homo sapiens_hsa051600.46586773
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45987014
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45457656
156Folate biosynthesis_Homo sapiens_hsa007900.44803895
157Estrogen signaling pathway_Homo sapiens_hsa049150.43613928
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43142481
159Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43127182
160Colorectal cancer_Homo sapiens_hsa052100.42705719
161Oocyte meiosis_Homo sapiens_hsa041140.41616801
162Fatty acid metabolism_Homo sapiens_hsa012120.41266202
163Fanconi anemia pathway_Homo sapiens_hsa034600.40112869
164Hippo signaling pathway_Homo sapiens_hsa043900.39496925
165Arginine and proline metabolism_Homo sapiens_hsa003300.39489380
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.38625505
167Pathways in cancer_Homo sapiens_hsa052000.38402515
168Prolactin signaling pathway_Homo sapiens_hsa049170.37956370
169Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37411494
170Type II diabetes mellitus_Homo sapiens_hsa049300.37404942
171Glutathione metabolism_Homo sapiens_hsa004800.36329391
172Endometrial cancer_Homo sapiens_hsa052130.36261581
173Asthma_Homo sapiens_hsa053100.33672416
174Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33446527
175Rap1 signaling pathway_Homo sapiens_hsa040150.32784879
176Tyrosine metabolism_Homo sapiens_hsa003500.32612131
177Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31690819
178HTLV-I infection_Homo sapiens_hsa051660.31058479
179PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30000223
180Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29937139
181Vitamin B6 metabolism_Homo sapiens_hsa007500.29651656
182Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27547848
183AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27280518
184Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27087936

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