CDC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.85282036
2DNA replication initiation (GO:0006270)5.78360881
3DNA strand elongation (GO:0022616)5.57430267
4DNA unwinding involved in DNA replication (GO:0006268)5.52826543
5telomere maintenance via semi-conservative replication (GO:0032201)5.32959896
6establishment of integrated proviral latency (GO:0075713)4.91577176
7nucleobase biosynthetic process (GO:0046112)4.79483779
8telomere maintenance via recombination (GO:0000722)4.77872658
9* DNA replication checkpoint (GO:0000076)4.76466155
10protein localization to kinetochore (GO:0034501)4.70797937
11mitotic recombination (GO:0006312)4.58846700
12purine nucleobase biosynthetic process (GO:0009113)4.58636952
13DNA replication-dependent nucleosome assembly (GO:0006335)4.43662131
14DNA replication-dependent nucleosome organization (GO:0034723)4.43662131
15mitotic metaphase plate congression (GO:0007080)4.40814125
16IMP biosynthetic process (GO:0006188)4.31865589
17* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.28020616
18telomere maintenance via telomere lengthening (GO:0010833)4.22131239
19CENP-A containing nucleosome assembly (GO:0034080)4.21695528
20chromatin remodeling at centromere (GO:0031055)4.17117104
21mitotic sister chromatid cohesion (GO:0007064)4.14282732
22mitotic nuclear envelope disassembly (GO:0007077)4.12151708
23nucleotide-excision repair, DNA gap filling (GO:0006297)4.12037235
24protein localization to chromosome, centromeric region (GO:0071459)4.06720754
25folic acid-containing compound biosynthetic process (GO:0009396)3.99127930
26formation of translation preinitiation complex (GO:0001731)3.96949565
27DNA replication-independent nucleosome organization (GO:0034724)3.94666624
28DNA replication-independent nucleosome assembly (GO:0006336)3.94666624
29nuclear pore organization (GO:0006999)3.93930681
30ribosome assembly (GO:0042255)3.83172181
31nuclear envelope disassembly (GO:0051081)3.80721466
32membrane disassembly (GO:0030397)3.80721466
33maturation of SSU-rRNA (GO:0030490)3.79934674
34IMP metabolic process (GO:0046040)3.77632541
35metaphase plate congression (GO:0051310)3.76806817
36establishment of viral latency (GO:0019043)3.73854054
37heterochromatin organization (GO:0070828)3.73119768
38kinetochore organization (GO:0051383)3.73110206
39mitotic chromosome condensation (GO:0007076)3.72994514
40ribosomal small subunit assembly (GO:0000028)3.68253997
41nuclear pore complex assembly (GO:0051292)3.68139456
42ribosome biogenesis (GO:0042254)3.67942896
43mitotic sister chromatid segregation (GO:0000070)3.67577799
44regulation of spindle organization (GO:0090224)3.59331879
45double-strand break repair via nonhomologous end joining (GO:0006303)3.57407696
46non-recombinational repair (GO:0000726)3.57407696
47histone exchange (GO:0043486)3.55255994
48proteasome assembly (GO:0043248)3.51391784
49DNA deamination (GO:0045006)3.47691837
50regulation of centriole replication (GO:0046599)3.47283499
51DNA duplex unwinding (GO:0032508)3.47161001
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.46932327
53attachment of spindle microtubules to kinetochore (GO:0008608)3.45710780
54DNA geometric change (GO:0032392)3.45408391
55L-serine metabolic process (GO:0006563)3.42665058
56establishment of chromosome localization (GO:0051303)3.40014635
57DNA ligation (GO:0006266)3.37878854
58sister chromatid segregation (GO:0000819)3.37831682
59ribonucleoprotein complex biogenesis (GO:0022613)3.37234209
60spliceosomal snRNP assembly (GO:0000387)3.35868373
61kinetochore assembly (GO:0051382)3.34900188
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33446596
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33411631
64regulation of translational fidelity (GO:0006450)3.31382139
65protein complex localization (GO:0031503)3.28828797
66ribosomal large subunit biogenesis (GO:0042273)3.27398710
67telomere maintenance (GO:0000723)3.27086934
68telomere organization (GO:0032200)3.26361623
69translesion synthesis (GO:0019985)3.26327327
70somatic hypermutation of immunoglobulin genes (GO:0016446)3.26096009
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26096009
72chromatin assembly or disassembly (GO:0006333)3.25678152
73transcription-coupled nucleotide-excision repair (GO:0006283)3.24553039
74* G1/S transition of mitotic cell cycle (GO:0000082)3.22207520
75* cell cycle G1/S phase transition (GO:0044843)3.22207520
76rRNA processing (GO:0006364)3.21339461
77DNA topological change (GO:0006265)3.21336509
78regulation of centrosome cycle (GO:0046605)3.21030606
79folic acid metabolic process (GO:0046655)3.20089444
80mitotic spindle checkpoint (GO:0071174)3.18610229
81mismatch repair (GO:0006298)3.16959936
82chromosome condensation (GO:0030261)3.13830469
83nucleobase-containing small molecule interconversion (GO:0015949)3.13827795
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12364669
85rRNA metabolic process (GO:0016072)3.11614485
86regulation of nuclear cell cycle DNA replication (GO:0033262)3.11264362
87spindle checkpoint (GO:0031577)3.09694520
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08608474
89negative regulation of ligase activity (GO:0051352)3.08608474
90negative regulation of chromosome segregation (GO:0051985)3.07694125
91postreplication repair (GO:0006301)3.06517862
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05271858
93viral transcription (GO:0019083)3.05152121
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04826101
95negative regulation of sister chromatid segregation (GO:0033046)3.04826101
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.04826101
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04826101
98meiotic chromosome segregation (GO:0045132)3.04675002
99translational termination (GO:0006415)3.04544460
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04069931
101translational initiation (GO:0006413)3.03192999
102regulation of helicase activity (GO:0051095)3.02631199
103base-excision repair (GO:0006284)3.01907139
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01613661
105regulation of mitotic sister chromatid separation (GO:0010965)3.01351294
106regulation of mitotic sister chromatid segregation (GO:0033047)3.01351294
107regulation of sister chromatid segregation (GO:0033045)3.01351294
108* DNA replication (GO:0006260)3.01144239
109nuclear envelope organization (GO:0006998)2.99705311
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99660054
111deoxyribonucleotide biosynthetic process (GO:0009263)2.98697362
112DNA conformation change (GO:0071103)2.98515726
113protein localization to chromosome (GO:0034502)2.98274960
114spindle assembly checkpoint (GO:0071173)2.97816672
115* mitotic cell cycle (GO:0000278)2.97750581
116pore complex assembly (GO:0046931)2.96809993
117* regulation of chromosome segregation (GO:0051983)2.96683030
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96398129
119protein K6-linked ubiquitination (GO:0085020)2.96107299
120ATP-dependent chromatin remodeling (GO:0043044)2.96043658
121regulation of DNA endoreduplication (GO:0032875)2.95686609
122DNA synthesis involved in DNA repair (GO:0000731)2.95145639
123DNA strand renaturation (GO:0000733)2.95027802
124cellular protein complex localization (GO:0034629)2.94741192
125regulation of mitotic spindle organization (GO:0060236)2.94684894
126spliceosomal complex assembly (GO:0000245)2.93805419
127rRNA modification (GO:0000154)2.93693544
128regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93663586
129mitotic spindle assembly checkpoint (GO:0007094)2.92685287
130chromosome segregation (GO:0007059)2.91186974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.28022943
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.10696154
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.03507929
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73038336
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20643578
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06086761
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88705618
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.76288317
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75761251
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74267200
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.59353458
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59253800
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56724607
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.56507320
15AR_21909140_ChIP-Seq_LNCAP_Human2.35305753
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33866795
17* XRN2_22483619_ChIP-Seq_HELA_Human2.23009943
18* E2F1_21310950_ChIP-Seq_MCF-7_Human2.22618257
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21764091
20VDR_23849224_ChIP-Seq_CD4+_Human2.12236595
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12033505
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08856435
23* E2F7_22180533_ChIP-Seq_HELA_Human10.3207198
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.99455032
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93336751
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90046016
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89789743
28FOXP3_21729870_ChIP-Seq_TREG_Human1.88711354
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87381448
30DCP1A_22483619_ChIP-Seq_HELA_Human1.84643390
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81133449
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78115588
33GABP_19822575_ChIP-Seq_HepG2_Human1.76666520
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75819305
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75091144
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73880249
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70007901
38TTF2_22483619_ChIP-Seq_HELA_Human1.68725741
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68336716
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67819814
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63993159
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61546817
43MYC_22102868_ChIP-Seq_BL_Human1.57568561
44CIITA_25753668_ChIP-Seq_RAJI_Human1.54086490
45* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49708645
46ELK1_19687146_ChIP-ChIP_HELA_Human1.49581950
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49407101
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49080445
49KDM5A_27292631_Chip-Seq_BREAST_Human1.46807315
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46639075
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46519207
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44605252
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.44428915
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39584042
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37637979
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29859974
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26816537
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25644798
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25591063
60* SRF_21415370_ChIP-Seq_HL-1_Mouse1.24186296
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22584935
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21765225
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19066600
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18531369
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18483083
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18295767
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17452153
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14548649
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11005942
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08465631
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.07442431
72TFEB_21752829_ChIP-Seq_HELA_Human1.07068445
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05185207
74ZNF263_19887448_ChIP-Seq_K562_Human1.03142923
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00467077
76* SOX17_20123909_ChIP-Seq_XEN_Mouse1.00121457
77NANOG_16153702_ChIP-ChIP_HESCs_Human0.99210445
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98667503
79VDR_21846776_ChIP-Seq_THP-1_Human0.98300063
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98110529
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97963643
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97350842
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95699779
84MYC_18940864_ChIP-ChIP_HL60_Human0.93572104
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91320619
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.90745137
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90583190
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89861615
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89590287
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88299692
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86916495
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86179637
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.85777643
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85269798
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85071910
96SPI1_23547873_ChIP-Seq_NB4_Human0.84494235
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84457071
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84169998
99CHD1_26751641_Chip-Seq_LNCaP_Human0.83585325
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.82455483
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81525229
102TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80036535
103* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80025226
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79713655
105SALL1_21062744_ChIP-ChIP_HESCs_Human0.74528439
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73546061
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73057148
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72616184
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.70455833
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70419996
111* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70416855
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69428699
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.69245301
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68934519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.74698920
2MP0010094_abnormal_chromosome_stability5.41062145
3MP0003111_abnormal_nucleus_morphology5.02853125
4MP0004957_abnormal_blastocyst_morpholog4.55518517
5MP0008057_abnormal_DNA_replication4.42368577
6MP0003077_abnormal_cell_cycle4.22585638
7MP0008058_abnormal_DNA_repair3.55641761
8MP0008007_abnormal_cellular_replicative2.93907417
9MP0008932_abnormal_embryonic_tissue2.83008596
10MP0002396_abnormal_hematopoietic_system2.68687778
11MP0003941_abnormal_skin_development2.58199522
12MP0001730_embryonic_growth_arrest2.52566307
13MP0003123_paternal_imprinting2.44100427
14MP0000350_abnormal_cell_proliferation2.39707303
15MP0010352_gastrointestinal_tract_polyps2.23294424
16MP0009697_abnormal_copulation2.17038984
17MP0010307_abnormal_tumor_latency2.16979870
18MP0008877_abnormal_DNA_methylation2.13440527
19MP0003786_premature_aging2.00704612
20MP0000490_abnormal_crypts_of1.82939418
21MP0001672_abnormal_embryogenesis/_devel1.81634281
22MP0005380_embryogenesis_phenotype1.81634281
23MP0001697_abnormal_embryo_size1.77525636
24MP0003718_maternal_effect1.72958281
25MP0002080_prenatal_lethality1.68416051
26MP0003984_embryonic_growth_retardation1.61843199
27MP0004808_abnormal_hematopoietic_stem1.57694260
28MP0002088_abnormal_embryonic_growth/wei1.57061556
29MP0005397_hematopoietic_system_phenotyp1.56579489
30MP0001545_abnormal_hematopoietic_system1.56579489
31MP0000313_abnormal_cell_death1.54745683
32MP0004147_increased_porphyrin_level1.53033321
33MP0002019_abnormal_tumor_incidence1.52515015
34MP0009333_abnormal_splenocyte_physiolog1.49831387
35MP0002085_abnormal_embryonic_tissue1.49405750
36MP0003656_abnormal_erythrocyte_physiolo1.47894148
37MP0002086_abnormal_extraembryonic_tissu1.43967109
38MP0002084_abnormal_developmental_patter1.36532635
39MP0003567_abnormal_fetal_cardiomyocyte1.33582865
40MP0002877_abnormal_melanocyte_morpholog1.32272622
41MP0003806_abnormal_nucleotide_metabolis1.31290826
42MP0004197_abnormal_fetal_growth/weight/1.28940295
43MP0002697_abnormal_eye_size1.25353308
44MP0004233_abnormal_muscle_weight1.22686282
45MP0006035_abnormal_mitochondrial_morpho1.21885252
46MP0002210_abnormal_sex_determination1.21649011
47MP0003121_genomic_imprinting1.20537813
48MP0005076_abnormal_cell_differentiation1.20381406
49MP0001346_abnormal_lacrimal_gland1.19598340
50MP0002398_abnormal_bone_marrow1.14679983
51MP0000703_abnormal_thymus_morphology1.14023230
52MP0001293_anophthalmia1.09740764
53MP0003315_abnormal_perineum_morphology1.09483775
54MP0002722_abnormal_immune_system1.08729357
55MP0001145_abnormal_male_reproductive1.08360734
56MP0004185_abnormal_adipocyte_glucose1.07704928
57MP0006054_spinal_hemorrhage1.07454804
58MP0000689_abnormal_spleen_morphology1.05056812
59MP0003890_abnormal_embryonic-extraembry1.02593001
60MP0005501_abnormal_skin_physiology1.01259997
61MP0002938_white_spotting1.01103608
62MP0003763_abnormal_thymus_physiology1.00352951
63MP0003186_abnormal_redox_activity0.97621118
64MP0001929_abnormal_gametogenesis0.97158566
65MP0010234_abnormal_vibrissa_follicle0.96798211
66MP0000653_abnormal_sex_gland0.93370661
67MP0000358_abnormal_cell_content/0.92217098
68MP0002160_abnormal_reproductive_system0.92153457
69MP0002429_abnormal_blood_cell0.91583822
70MP0002796_impaired_skin_barrier0.89817140
71MP0005384_cellular_phenotype0.88656210
72MP0000579_abnormal_nail_morphology0.86833629
73MP0009672_abnormal_birth_weight0.86044464
74MP0005621_abnormal_cell_physiology0.84644521
75MP0001661_extended_life_span0.84277462
76MP0003221_abnormal_cardiomyocyte_apopto0.81605388
77MP0001119_abnormal_female_reproductive0.80216586
78MP0005389_reproductive_system_phenotype0.78175776
79MP0000858_altered_metastatic_potential0.77635154
80MP0009053_abnormal_anal_canal0.76908639
81MP0010030_abnormal_orbit_morphology0.76333893
82MP0002132_abnormal_respiratory_system0.75156734
83MP0003943_abnormal_hepatobiliary_system0.73915518
84MP0001188_hyperpigmentation0.72828140
85MP0009278_abnormal_bone_marrow0.71727435
86MP0000716_abnormal_immune_system0.71351611
87MP0001881_abnormal_mammary_gland0.70677264
88MP0002233_abnormal_nose_morphology0.70516984
89MP0002111_abnormal_tail_morphology0.70093310
90MP0000627_abnormal_mammary_gland0.67771964
91MP0003861_abnormal_nervous_system0.67207101
92MP0009703_decreased_birth_body0.67150932
93MP0001915_intracranial_hemorrhage0.66889156
94MP0005023_abnormal_wound_healing0.66668884
95MP0000647_abnormal_sebaceous_gland0.66275089
96MP0000762_abnormal_tongue_morphology0.65918492
97MP0006292_abnormal_olfactory_placode0.64733112
98MP0003755_abnormal_palate_morphology0.64243042
99MP0003119_abnormal_digestive_system0.63483165
100MP0000537_abnormal_urethra_morphology0.62852974
101MP0005623_abnormal_meninges_morphology0.60784255
102MP0003937_abnormal_limbs/digits/tail_de0.60189914
103MP0001849_ear_inflammation0.60127571
104MP0000477_abnormal_intestine_morphology0.59922548
105MP0001853_heart_inflammation0.59745198
106MP0003566_abnormal_cell_adhesion0.59567253
107MP0002095_abnormal_skin_pigmentation0.59328581
108MP0005395_other_phenotype0.58925143
109MP0005408_hypopigmentation0.58841708
110MP0002092_abnormal_eye_morphology0.58511784
111MP0004264_abnormal_extraembryonic_tissu0.58178013
112MP0000432_abnormal_head_morphology0.57901052
113MP0003935_abnormal_craniofacial_develop0.56296779
114MP0006036_abnormal_mitochondrial_physio0.56133355
115MP0000566_synostosis0.56065405
116MP0001919_abnormal_reproductive_system0.55281742
117MP0002060_abnormal_skin_morphology0.54682001
118MP0003699_abnormal_female_reproductive0.52901290
119MP0003705_abnormal_hypodermis_morpholog0.51053399
120MP0005266_abnormal_metabolism0.50532507
121MP0000428_abnormal_craniofacial_morphol0.49871096
122MP0002075_abnormal_coat/hair_pigmentati0.49824308
123MP0008770_decreased_survivor_rate0.49503732
124MP0005075_abnormal_melanosome_morpholog0.49143478
125MP0001800_abnormal_humoral_immune0.48987076
126MP0002102_abnormal_ear_morphology0.48809369
127MP0003448_altered_tumor_morphology0.47271953
128MP0002420_abnormal_adaptive_immunity0.47159269
129MP0001286_abnormal_eye_development0.46466685
130MP0002161_abnormal_fertility/fecundity0.46411558
131MP0001819_abnormal_immune_cell0.46020761

Predicted human phenotypes

RankGene SetZ-score
1* Birth length less than 3rd percentile (HP:0003561)5.12677910
2Breast hypoplasia (HP:0003187)4.78763818
3Chromsome breakage (HP:0040012)4.55553926
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33866666
5Abnormality of cells of the erythroid lineage (HP:0012130)4.19501697
6Abnormal number of erythroid precursors (HP:0012131)4.12339377
7Reticulocytopenia (HP:0001896)4.07138182
8Abnormality of chromosome stability (HP:0003220)3.71369102
9Oral leukoplakia (HP:0002745)3.64789395
10Meckel diverticulum (HP:0002245)3.53978618
11Abnormality of the preputium (HP:0100587)3.48309631
12Selective tooth agenesis (HP:0001592)3.41934225
13Abnormality of the ileum (HP:0001549)3.37941332
14Abnormality of the anterior horn cell (HP:0006802)3.30901274
15Degeneration of anterior horn cells (HP:0002398)3.30901274
16Impulsivity (HP:0100710)3.27175029
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.23077727
18Carpal bone hypoplasia (HP:0001498)3.19558148
19* Patellar aplasia (HP:0006443)3.19139786
20Ependymoma (HP:0002888)3.18198481
21Colon cancer (HP:0003003)3.16844696
22Abnormality of the heme biosynthetic pathway (HP:0010472)3.15961380
23Aplastic anemia (HP:0001915)3.15846982
24Rough bone trabeculation (HP:0100670)3.08044395
25Medulloblastoma (HP:0002885)3.03335016
26* Aplasia/Hypoplasia of the patella (HP:0006498)2.99074568
27Small intestinal stenosis (HP:0012848)2.94628378
28Duodenal stenosis (HP:0100867)2.94628378
29Cerebral hypomyelination (HP:0006808)2.91427556
30Myelodysplasia (HP:0002863)2.90968856
31Agnosia (HP:0010524)2.89200958
32Absent thumb (HP:0009777)2.88789682
33Abnormality of glycolysis (HP:0004366)2.82867827
34Embryonal renal neoplasm (HP:0011794)2.81705326
35Bone marrow hypocellularity (HP:0005528)2.81669009
36Macrocytic anemia (HP:0001972)2.75943381
37Microvesicular hepatic steatosis (HP:0001414)2.75370323
38Abnormality of the labia minora (HP:0012880)2.73419892
39Absent radius (HP:0003974)2.71469535
40Pallor (HP:0000980)2.66955940
41Ectopic kidney (HP:0000086)2.60153122
42Neoplasm of the pancreas (HP:0002894)2.52502777
43Increased serum pyruvate (HP:0003542)2.52239996
44Aplasia involving forearm bones (HP:0009822)2.51875211
45Absent forearm bone (HP:0003953)2.51875211
46Microretrognathia (HP:0000308)2.51410666
47Premature graying of hair (HP:0002216)2.50037500
48Rhabdomyosarcoma (HP:0002859)2.49281777
49Sloping forehead (HP:0000340)2.41806281
5011 pairs of ribs (HP:0000878)2.39584910
51Horseshoe kidney (HP:0000085)2.38151500
52Abnormality of the carotid arteries (HP:0005344)2.38142902
53Abnormal number of incisors (HP:0011064)2.36187684
54Abnormality of the duodenum (HP:0002246)2.34428705
55Basal cell carcinoma (HP:0002671)2.33989026
56Progressive muscle weakness (HP:0003323)2.32804012
57Cortical dysplasia (HP:0002539)2.32482660
58Tracheoesophageal fistula (HP:0002575)2.30548852
59Premature ovarian failure (HP:0008209)2.28237671
60Abnormality of reticulocytes (HP:0004312)2.26544371
61Cafe-au-lait spot (HP:0000957)2.24778793
62Increased nuchal translucency (HP:0010880)2.23930778
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.23894958
64Duplicated collecting system (HP:0000081)2.23570018
65Cellular immunodeficiency (HP:0005374)2.23527937
66Prominent nose (HP:0000448)2.22024532
67Secondary amenorrhea (HP:0000869)2.21696102
68Choanal atresia (HP:0000453)2.20930961
69Facial cleft (HP:0002006)2.20871059
70Abnormal lung lobation (HP:0002101)2.19696552
71Abnormal trabecular bone morphology (HP:0100671)2.19473235
72Multiple enchondromatosis (HP:0005701)2.16787147
73Triphalangeal thumb (HP:0001199)2.15282439
74Abnormality of cochlea (HP:0000375)2.13433989
75Proximal placement of thumb (HP:0009623)2.13099772
76Clubbing of toes (HP:0100760)2.11697775
77Squamous cell carcinoma (HP:0002860)2.11319545
78High pitched voice (HP:0001620)2.10923273
79Short thumb (HP:0009778)2.10650358
80Megaloblastic anemia (HP:0001889)2.09301197
81Lymphoma (HP:0002665)2.08072900
82Deviation of the thumb (HP:0009603)2.05391121
83Abnormality of methionine metabolism (HP:0010901)2.03351845
84Trismus (HP:0000211)2.02313242
85Abnormality of pyrimidine metabolism (HP:0004353)1.99836093
86Pancytopenia (HP:0001876)1.99426519
87Aplasia/Hypoplasia of the sternum (HP:0006714)1.98695246
88Duplication of thumb phalanx (HP:0009942)1.97931471
89Amaurosis fugax (HP:0100576)1.97205956
90Supernumerary spleens (HP:0009799)1.96537567
91* Atresia of the external auditory canal (HP:0000413)1.96381221
92Spastic diplegia (HP:0001264)1.95633692
93Cleft eyelid (HP:0000625)1.95501422
94Ureteral duplication (HP:0000073)1.94140983
95Facial hemangioma (HP:0000329)1.93100251
96Deep philtrum (HP:0002002)1.92921919
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92850859
98Abnormal spermatogenesis (HP:0008669)1.88894355
99Abnormality of the renal collecting system (HP:0004742)1.87332372
100Entropion (HP:0000621)1.86539748
101Abnormality of DNA repair (HP:0003254)1.86279648
102Atrophy/Degeneration involving motor neurons (HP:0007373)1.86138047
103Progressive external ophthalmoplegia (HP:0000590)1.86033788
104Thrombocytosis (HP:0001894)1.84916029
105Abnormality of the astrocytes (HP:0100707)1.84817428
106Astrocytoma (HP:0009592)1.84817428
107Glioma (HP:0009733)1.81896050
108Neoplasm of the colon (HP:0100273)1.78215208
109Overlapping toe (HP:0001845)1.78178515
110* Slender long bone (HP:0003100)1.77922662
111Nephroblastoma (Wilms tumor) (HP:0002667)1.76336848
112Glossoptosis (HP:0000162)1.76154455
113Abnormality of the fetal cardiovascular system (HP:0010948)1.75530670
114Abnormal umbilical cord blood vessels (HP:0011403)1.75530670
115Single umbilical artery (HP:0001195)1.75530670
116Abnormality of the umbilical cord (HP:0010881)1.73037960
117Overriding aorta (HP:0002623)1.72561618
118Volvulus (HP:0002580)1.72357375
119Neoplasm of striated muscle (HP:0009728)1.72174075
120Type I transferrin isoform profile (HP:0003642)1.70755222
121Embryonal neoplasm (HP:0002898)1.69703471
122Poikiloderma (HP:0001029)1.69636000
123Arteriovenous malformation (HP:0100026)1.67680864
124High anterior hairline (HP:0009890)1.66979654
125Increased hepatocellular lipid droplets (HP:0006565)1.66549765
126Homocystinuria (HP:0002156)1.63809881
127Abnormality of homocysteine metabolism (HP:0010919)1.63809881
128Hypoplastic pelvis (HP:0008839)1.62354073
129Postnatal microcephaly (HP:0005484)1.61670100
130Sparse eyelashes (HP:0000653)1.59139364
131Reduced antithrombin III activity (HP:0001976)1.58705418
132Microglossia (HP:0000171)1.58167318
133Acute encephalopathy (HP:0006846)1.57512527
134Hypoplasia of the pons (HP:0012110)1.56482359
135Abnormalities of placenta or umbilical cord (HP:0001194)1.55737466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.08025310
2WEE14.73772298
3BUB14.42547890
4EIF2AK13.52669253
5NEK22.79626129
6VRK22.78162437
7TSSK62.61625521
8SRPK12.57005704
9NEK12.41608988
10PLK42.36616935
11TTK2.35285677
12BRSK22.29801356
13NME22.27559229
14ACVR1B2.08443434
15EIF2AK31.99431011
16* PLK11.99104257
17TAF11.91575482
18VRK11.90310379
19ATR1.85938228
20SMG11.84313521
21TLK11.84162191
22STK161.82902306
23AURKB1.75243369
24CDK71.74605376
25BRSK11.72572719
26MKNK11.65175242
27PLK31.64989092
28TESK21.58274907
29RPS6KB21.52525275
30PASK1.48945122
31CHEK21.47933953
32DYRK31.44817674
33EEF2K1.43484082
34CDK41.42131159
35MAP3K81.41503935
36STK101.39681018
37CDK121.29385897
38SCYL21.28902061
39CHEK11.28140534
40CCNB11.27860877
41AURKA1.27312792
42MKNK21.26663225
43RPS6KA41.23726846
44ZAK1.20677990
45STK41.14547357
46MST1R1.10360242
47TRIM281.06576651
48EPHA21.06119709
49ATM0.93934101
50ERBB40.93276311
51PIM10.92375266
52PIM20.90087706
53* CDK20.89330813
54TGFBR10.86501221
55PAK40.85562252
56NUAK10.84411359
57ALK0.80685317
58MAP3K100.78028629
59EIF2AK20.76250709
60PDK20.72715535
61LRRK20.72158852
62MAP4K10.71473607
63CDK80.71328311
64PNCK0.71018185
65CSNK2A20.68485157
66CSNK2A10.66835851
67CDK10.66419104
68STK30.66214305
69LATS20.66194778
70PAK10.65016454
71FLT30.64037734
72CDK60.64008585
73MET0.62484246
74MELK0.62444879
75CLK10.59839307
76LATS10.59218740
77BRAF0.59009987
78BRD40.57622038
79KDR0.53559055
80RPS6KA50.51991870
81PKN20.49998948
82FGFR10.45182917
83PRKCI0.45115371
84PBK0.45003409
85CDK90.44510433
86STK240.41924914
87MAP2K30.40672446
88MAPKAPK50.38712018
89CDK180.37948619
90STK38L0.37888623
91ICK0.37510248
92CSNK1G10.36805531
93CDK150.36025434
94PRKDC0.34269270
95BTK0.32768516
96PLK20.32578343
97CDK140.32447812
98MAP3K90.32215314
99TESK10.32056884
100CAMK1D0.31942249
101IRAK30.31387913
102CSNK1E0.31209338
103MAP3K110.30891531
104AKT20.30055259
105TEC0.28287766
106MTOR0.28251438
107CSNK1G30.28126214
108CAMK1G0.27663481
109CSNK1A1L0.24124552
110PTK20.24010552
111PAK20.23547187
112CSNK1D0.23545873
113GRK60.23139208
114* MAPK140.22011504
115MAPKAPK30.21413806
116DAPK10.21233818
117RAF10.20665115
118ILK0.19194124
119CSF1R0.18768082
120MAPK110.18703664
121MST40.18401600
122NEK90.17040993
123DYRK20.16840278
124RPS6KA60.16284806
125CDK11A0.16130945
126AKT10.15930438
127LYN0.15516793
128ABL20.15310312
129NME10.14416025

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.78885643
2Mismatch repair_Homo sapiens_hsa034304.63472587
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53024674
4Homologous recombination_Homo sapiens_hsa034403.29789519
5Base excision repair_Homo sapiens_hsa034103.23672876
6Spliceosome_Homo sapiens_hsa030403.13426345
7RNA polymerase_Homo sapiens_hsa030203.06971820
8RNA transport_Homo sapiens_hsa030133.04415712
9Nucleotide excision repair_Homo sapiens_hsa034203.02317513
10Proteasome_Homo sapiens_hsa030503.00843889
11* Cell cycle_Homo sapiens_hsa041102.95991845
12Ribosome_Homo sapiens_hsa030102.90076628
13One carbon pool by folate_Homo sapiens_hsa006702.83825112
14Pyrimidine metabolism_Homo sapiens_hsa002402.56180579
15Fanconi anemia pathway_Homo sapiens_hsa034602.45144118
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30995649
17Non-homologous end-joining_Homo sapiens_hsa034502.16603028
18RNA degradation_Homo sapiens_hsa030181.75973138
19Basal transcription factors_Homo sapiens_hsa030221.75358019
20p53 signaling pathway_Homo sapiens_hsa041151.70912690
21mRNA surveillance pathway_Homo sapiens_hsa030151.52639303
22Systemic lupus erythematosus_Homo sapiens_hsa053221.39945990
23Purine metabolism_Homo sapiens_hsa002301.38790663
24Pyruvate metabolism_Homo sapiens_hsa006201.36131192
25Vitamin B6 metabolism_Homo sapiens_hsa007501.34558047
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19442183
27Epstein-Barr virus infection_Homo sapiens_hsa051691.13996031
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03819189
29Pentose phosphate pathway_Homo sapiens_hsa000301.01858378
30Viral carcinogenesis_Homo sapiens_hsa052031.00213527
31Antigen processing and presentation_Homo sapiens_hsa046120.97866405
32Oocyte meiosis_Homo sapiens_hsa041140.97458229
33Folate biosynthesis_Homo sapiens_hsa007900.93718211
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93714440
35Cysteine and methionine metabolism_Homo sapiens_hsa002700.92799441
36Fatty acid elongation_Homo sapiens_hsa000620.92352896
37Biosynthesis of amino acids_Homo sapiens_hsa012300.92122697
38Herpes simplex infection_Homo sapiens_hsa051680.89496864
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87078410
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83440274
41Steroid biosynthesis_Homo sapiens_hsa001000.79154067
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.78481443
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.77842567
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77042542
45Selenocompound metabolism_Homo sapiens_hsa004500.76971758
46Oxidative phosphorylation_Homo sapiens_hsa001900.75150630
47Propanoate metabolism_Homo sapiens_hsa006400.72892036
48HTLV-I infection_Homo sapiens_hsa051660.69983067
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68468515
50Small cell lung cancer_Homo sapiens_hsa052220.59766667
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59582208
52MicroRNAs in cancer_Homo sapiens_hsa052060.55168670
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55105506
54Legionellosis_Homo sapiens_hsa051340.54370786
55Glutathione metabolism_Homo sapiens_hsa004800.52589647
56Adherens junction_Homo sapiens_hsa045200.51911088
57Sulfur relay system_Homo sapiens_hsa041220.50425612
58Carbon metabolism_Homo sapiens_hsa012000.50424219
59Thyroid cancer_Homo sapiens_hsa052160.48602711
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48230221
61Primary immunodeficiency_Homo sapiens_hsa053400.47858556
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46350655
63Alcoholism_Homo sapiens_hsa050340.45200593
64Protein export_Homo sapiens_hsa030600.44788938
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43659527
66Apoptosis_Homo sapiens_hsa042100.43646694
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42148764
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41946829
69Alzheimers disease_Homo sapiens_hsa050100.38717875
70Arginine and proline metabolism_Homo sapiens_hsa003300.38361215
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37486550
72Measles_Homo sapiens_hsa051620.37396247
73Fatty acid metabolism_Homo sapiens_hsa012120.36435153
74Hepatitis B_Homo sapiens_hsa051610.36173945
75N-Glycan biosynthesis_Homo sapiens_hsa005100.34981949
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34955954
77Arginine biosynthesis_Homo sapiens_hsa002200.31848142
78Huntingtons disease_Homo sapiens_hsa050160.31509491
79Fructose and mannose metabolism_Homo sapiens_hsa000510.28661405
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28516675
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27355766
82Wnt signaling pathway_Homo sapiens_hsa043100.26847924
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26518760
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25602602
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.25146067
86Bladder cancer_Homo sapiens_hsa052190.24841920
87Colorectal cancer_Homo sapiens_hsa052100.24323361
88Chronic myeloid leukemia_Homo sapiens_hsa052200.22754687
89Hematopoietic cell lineage_Homo sapiens_hsa046400.21277605
90TGF-beta signaling pathway_Homo sapiens_hsa043500.20684652
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20545589
92Shigellosis_Homo sapiens_hsa051310.20323046
93Metabolic pathways_Homo sapiens_hsa011000.20120628
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18670685
95HIF-1 signaling pathway_Homo sapiens_hsa040660.18634463
96Influenza A_Homo sapiens_hsa051640.18115016
97Hippo signaling pathway_Homo sapiens_hsa043900.17814637
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16912376
99Pancreatic cancer_Homo sapiens_hsa052120.16867188
100Vitamin digestion and absorption_Homo sapiens_hsa049770.16815072
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16159575
102Renin-angiotensin system_Homo sapiens_hsa046140.15912196
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15609008
104Galactose metabolism_Homo sapiens_hsa000520.15214706
105Tight junction_Homo sapiens_hsa045300.15069288
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14481178
107Viral myocarditis_Homo sapiens_hsa054160.14002422
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13689933
109Pathways in cancer_Homo sapiens_hsa052000.12242970
110Melanoma_Homo sapiens_hsa052180.11759188
111Notch signaling pathway_Homo sapiens_hsa043300.11418393
112Hedgehog signaling pathway_Homo sapiens_hsa043400.11302921
113Non-small cell lung cancer_Homo sapiens_hsa052230.10736967
114Prostate cancer_Homo sapiens_hsa052150.10720421
115Basal cell carcinoma_Homo sapiens_hsa052170.09805194
116Regulation of autophagy_Homo sapiens_hsa041400.09503387
117Acute myeloid leukemia_Homo sapiens_hsa052210.08892804
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.08855660
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.08838353
120Lysine degradation_Homo sapiens_hsa003100.07431967
121mTOR signaling pathway_Homo sapiens_hsa041500.07415935
122Sulfur metabolism_Homo sapiens_hsa009200.06966739
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06529225
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05928626
125Parkinsons disease_Homo sapiens_hsa050120.05130851
126Tyrosine metabolism_Homo sapiens_hsa003500.04640256

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