CDC42EP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein retention in ER lumen (GO:0006621)4.61397095
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.46860132
3Golgi transport vesicle coating (GO:0048200)4.22384940
4COPI coating of Golgi vesicle (GO:0048205)4.22384940
5axon ensheathment in central nervous system (GO:0032291)4.10933485
6central nervous system myelination (GO:0022010)4.10933485
7planar cell polarity pathway involved in neural tube closure (GO:0090179)4.10380223
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.74940677
9L-phenylalanine catabolic process (GO:0006559)3.72864602
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72864602
11cell-substrate junction assembly (GO:0007044)3.66313827
12L-phenylalanine metabolic process (GO:0006558)3.63127373
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.63127373
14retina vasculature morphogenesis in camera-type eye (GO:0061299)3.55537451
15creatine metabolic process (GO:0006600)3.54308372
16adherens junction assembly (GO:0034333)3.47823720
17myelin maintenance (GO:0043217)3.42989262
18transcytosis (GO:0045056)3.38977704
19alpha-linolenic acid metabolic process (GO:0036109)3.38086106
20endodermal cell differentiation (GO:0035987)3.36170848
21regulation of early endosome to late endosome transport (GO:2000641)3.33793777
22collagen fibril organization (GO:0030199)3.27882389
23cell-substrate adherens junction assembly (GO:0007045)3.26473373
24focal adhesion assembly (GO:0048041)3.26473373
25low-density lipoprotein particle clearance (GO:0034383)3.22803133
26proline biosynthetic process (GO:0006561)3.21180233
27vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.11709706
28renal filtration (GO:0097205)3.09457885
29semaphorin-plexin signaling pathway (GO:0071526)3.08129247
30positive regulation of osteoblast proliferation (GO:0033690)3.03591820
31endothelial cell morphogenesis (GO:0001886)3.03579120
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00690875
33regulation of plasminogen activation (GO:0010755)3.00171726
34vascular endothelial growth factor signaling pathway (GO:0038084)3.00156548
35bundle of His cell to Purkinje myocyte communication (GO:0086069)2.99712064
36lymphangiogenesis (GO:0001946)2.97529196
37intestinal cholesterol absorption (GO:0030299)2.96594673
38basement membrane organization (GO:0071711)2.96502002
39negative regulation of catenin import into nucleus (GO:0035414)2.96204169
40regulation of extracellular matrix disassembly (GO:0010715)2.95498930
41cochlea morphogenesis (GO:0090103)2.93456793
42aspartate family amino acid catabolic process (GO:0009068)2.92878814
43barbed-end actin filament capping (GO:0051016)2.92558010
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.89427724
45regulation of cardioblast differentiation (GO:0051890)2.88350136
46branching involved in salivary gland morphogenesis (GO:0060445)2.87220506
47regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.87194779
48negative regulation of fibrinolysis (GO:0051918)2.86837032
49fatty acid elongation (GO:0030497)2.86456395
50activation of Rac GTPase activity (GO:0032863)2.86402593
51chondrocyte proliferation (GO:0035988)2.85983602
52regulation of apoptotic process involved in morphogenesis (GO:1902337)2.84872617
53negative regulation of fatty acid transport (GO:2000192)2.83507332
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.83492354
55glomerular filtration (GO:0003094)2.82684496
56positive regulation of extracellular matrix organization (GO:1903055)2.82398393
57negative regulation of chondrocyte differentiation (GO:0032331)2.82035911
58axon ensheathment (GO:0008366)2.80212126
59ensheathment of neurons (GO:0007272)2.80212126
60regulation of mammary gland epithelial cell proliferation (GO:0033599)2.77840927
61proline metabolic process (GO:0006560)2.77495960
62endothelial cell chemotaxis (GO:0035767)2.77391330
63collagen metabolic process (GO:0032963)2.75458527
64protein localization to endosome (GO:0036010)2.72641000
65apoptotic process involved in morphogenesis (GO:0060561)2.72164355
66myelination (GO:0042552)2.72160127
67protein heterotrimerization (GO:0070208)2.71500692
68hemidesmosome assembly (GO:0031581)2.69996116
69positive regulation of blood vessel endothelial cell migration (GO:0043536)2.68968648
70heart trabecula formation (GO:0060347)2.68647059
71regulation of establishment of planar polarity (GO:0090175)2.67437320
72biotin metabolic process (GO:0006768)2.66173596
73sulfur amino acid catabolic process (GO:0000098)2.64999764
74fatty acid beta-oxidation (GO:0006635)2.64919429
75atrioventricular valve morphogenesis (GO:0003181)2.64885482
76epithelial cell-cell adhesion (GO:0090136)2.64751847
77positive regulation of fatty acid beta-oxidation (GO:0032000)2.64592505
78cell-cell junction maintenance (GO:0045217)2.64460963
79adhesion of symbiont to host (GO:0044406)2.64258637
80negative regulation of cell size (GO:0045792)2.63880729
81extracellular matrix assembly (GO:0085029)2.63348275
82extracellular fibril organization (GO:0043206)2.61834195
83extracellular matrix disassembly (GO:0022617)2.61573649
84plasma membrane repair (GO:0001778)2.61264178
85multicellular organismal macromolecule metabolic process (GO:0044259)2.57716433
86acetyl-CoA metabolic process (GO:0006084)2.57359815
87fatty-acyl-CoA biosynthetic process (GO:0046949)2.57287427
88collagen catabolic process (GO:0030574)2.56932900
89tooth mineralization (GO:0034505)2.56306293
90plasma lipoprotein particle clearance (GO:0034381)2.54886520
91glyoxylate metabolic process (GO:0046487)2.54829097
92positive regulation of receptor recycling (GO:0001921)2.53638053
93cell adhesion mediated by integrin (GO:0033627)2.53193338
94embryonic skeletal joint morphogenesis (GO:0060272)2.53029881
95lysine metabolic process (GO:0006553)2.52623450
96lysine catabolic process (GO:0006554)2.52623450
97thioester biosynthetic process (GO:0035384)2.52570220
98acyl-CoA biosynthetic process (GO:0071616)2.52570220
99protein maturation by protein folding (GO:0022417)2.52482475
100heme transport (GO:0015886)2.52480396
101dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51752856
102establishment of apical/basal cell polarity (GO:0035089)2.51642384
103adhesion of symbiont to host cell (GO:0044650)2.51157290
104virion attachment to host cell (GO:0019062)2.51157290
105regulation of cholesterol homeostasis (GO:2000188)2.51128388
106cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.50988064
107lymph vessel development (GO:0001945)2.50695217
108cysteine metabolic process (GO:0006534)2.50353831
109sarcomere organization (GO:0045214)2.50197782
110response to mercury ion (GO:0046689)2.49831784
111convergent extension (GO:0060026)2.49208492
112branched-chain amino acid catabolic process (GO:0009083)2.49133318
113positive regulation of fatty acid oxidation (GO:0046321)2.49058734
114protein targeting to plasma membrane (GO:0072661)2.47656867
115cytoskeletal anchoring at plasma membrane (GO:0007016)2.46235287
116cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.46173392
117negative regulation of protein localization to cell surface (GO:2000009)2.45844554
118regulation of transforming growth factor beta1 production (GO:0032908)2.45549677
119fatty acid catabolic process (GO:0009062)2.45500758
120cell migration involved in heart development (GO:0060973)2.44467756
121type B pancreatic cell proliferation (GO:0044342)2.43786806
122actin filament depolymerization (GO:0030042)2.43745275
123regulation of fibrinolysis (GO:0051917)2.43555267
124desmosome organization (GO:0002934)2.43247491
125cell migration involved in sprouting angiogenesis (GO:0002042)2.43165558
126multicellular organismal metabolic process (GO:0044236)2.43005657
127epoxygenase P450 pathway (GO:0019373)2.42607863
128long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.42330354
129regulation of glucose import in response to insulin stimulus (GO:2001273)2.42318068
130regulation of sequestering of triglyceride (GO:0010889)2.42111463
131short-chain fatty acid metabolic process (GO:0046459)2.41993815
132regulation of cholesterol biosynthetic process (GO:0045540)2.41644915
133endocardial cushion development (GO:0003197)2.40792617
134protein carboxylation (GO:0018214)2.40448115
135peptidyl-glutamic acid carboxylation (GO:0017187)2.40448115
136L-serine metabolic process (GO:0006563)2.39535761
137muscle cell migration (GO:0014812)2.39450049
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.39442446
139regulation of extracellular matrix organization (GO:1903053)2.39376873
140apoptotic cell clearance (GO:0043277)2.39330553
141fatty acid oxidation (GO:0019395)2.39043792
142peripheral nervous system axon ensheathment (GO:0032292)2.38994498
143myelination in peripheral nervous system (GO:0022011)2.38994498
144embryo implantation (GO:0007566)2.38932343
145glomerular basement membrane development (GO:0032836)2.38483409
146multicellular organismal catabolic process (GO:0044243)2.38291033
147fatty-acyl-CoA metabolic process (GO:0035337)2.37920486
148notochord development (GO:0030903)2.37788002
149stress fiber assembly (GO:0043149)2.36087666
150extracellular matrix organization (GO:0030198)2.35670296
151skin morphogenesis (GO:0043589)2.35106723
152extracellular structure organization (GO:0043062)2.34689413
153bone trabecula formation (GO:0060346)2.34521097
154negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.34141655
155very long-chain fatty acid metabolic process (GO:0000038)2.34095215
156homocysteine metabolic process (GO:0050667)2.33437256
157peptidyl-tyrosine autophosphorylation (GO:0038083)2.33244715
158regulation of triglyceride catabolic process (GO:0010896)2.33035708
159lipid oxidation (GO:0034440)2.32871914
160regulation of cholesterol metabolic process (GO:0090181)2.30919520
1614-hydroxyproline metabolic process (GO:0019471)2.30860065
162blood vessel endothelial cell migration (GO:0043534)2.30660758
163regulation of lipoprotein metabolic process (GO:0050746)2.29202329
164positive regulation of triglyceride metabolic process (GO:0090208)2.29032080
165gap junction assembly (GO:0016264)2.27530803
166regulation of fatty acid oxidation (GO:0046320)2.27053304
167aromatic amino acid family catabolic process (GO:0009074)2.26637501
168cardiac myofibril assembly (GO:0055003)2.25983849
169trabecula formation (GO:0060343)2.25515960
170peptidyl-proline hydroxylation (GO:0019511)2.25473242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.18155742
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.54823555
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.54786527
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.67753067
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.53506126
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.22218810
7CLOCK_20551151_ChIP-Seq_293T_Human3.11807936
8* LXR_22158963_ChIP-Seq_LIVER_Mouse2.90842720
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.89136108
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70151935
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.61813893
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.59854727
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46118363
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.18201912
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.10865099
16ZNF263_19887448_ChIP-Seq_K562_Human2.04820912
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.03683600
18* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98464156
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.97799557
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95570310
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87739055
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74915155
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68837150
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66778363
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.65241493
26* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63930998
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.63236430
28* TBX20_22080862_ChIP-Seq_HEART_Mouse1.62730041
29* TBX20_22328084_ChIP-Seq_HEART_Mouse1.62730041
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61708715
31* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.60298372
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59349373
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.58453063
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.56039994
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50643932
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49926519
37* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49150537
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.47947353
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46991703
40* TET1_21451524_ChIP-Seq_MESCs_Mouse1.46923591
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45776227
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44487069
43RACK7_27058665_Chip-Seq_MCF-7_Human1.43510338
44* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39682210
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37489780
46UBF1/2_26484160_Chip-Seq_HMECs_Human1.37051417
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.36438156
48KDM2B_26808549_Chip-Seq_DND41_Human1.35434988
49CJUN_26792858_Chip-Seq_BT549_Human1.35076493
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34930525
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34201668
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31890533
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31452078
54* SA1_27219007_Chip-Seq_ERYTHROID_Human1.31187519
55SOX2_20726797_ChIP-Seq_SW620_Human1.30781739
56VDR_21846776_ChIP-Seq_THP-1_Human1.29690175
57P68_20966046_ChIP-Seq_HELA_Human1.28990392
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28956962
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27972517
60CTCF_27219007_Chip-Seq_Bcells_Human1.27678509
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26839285
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26581924
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26492861
64LXR_22292898_ChIP-Seq_THP-1_Human1.25322275
65CREB1_26743006_Chip-Seq_LNCaP_Human1.23053571
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22784247
67* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22330852
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22223954
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22211315
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21938147
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21189360
72* SMC4_20622854_ChIP-Seq_HELA_Human1.21062535
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20934342
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.19855228
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19254756
76TCF7_22412390_ChIP-Seq_EML_Mouse1.19238253
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18620712
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17646982
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17646982
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.16451046
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.15289665
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13922259
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13380613
84* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12680658
85* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10592591
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10237721
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10131211
88* GATA4_25053715_ChIP-Seq_YYC3_Human1.09262560
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08420371
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06421056
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06421056
92* ATF3_27146783_Chip-Seq_COLON_Human1.06190578
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.05826890
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05748384
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04715180
96STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04603067
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.04580528
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04411286
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03581263
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.03353045
101KDM2B_26808549_Chip-Seq_K562_Human1.03253445
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01480756
103* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01283231
104* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99608683
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99433882
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99186623
107SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98724775
108EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98674424
109SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98229310
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97474143
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.95954601
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95811846
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95384387
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95045750
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94797161
116NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92755836
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92598165
118* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92245966
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92245509
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.92150408
121EED_16625203_ChIP-ChIP_MESCs_Mouse0.91747837
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90665732
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90665732
124TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90027978
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89701768
126SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89677976
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88712182
128* TP63_22573176_ChIP-Seq_HFKS_Human0.88640555
129* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88462731
130* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88430999
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87899272
132* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87587212
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87568215
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87340858
135TP53_22127205_ChIP-Seq_IMR90_Human0.86774874
136* GATA1_19941826_ChIP-Seq_K562_Human0.86692121
137KLF5_25053715_ChIP-Seq_YYC3_Human0.86482574
138* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85876059
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85686507
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85197813
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84988916
142DROSHA_22980978_ChIP-Seq_HELA_Human0.84149488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.34253097
2MP0004272_abnormal_basement_membrane3.28399234
3MP0003705_abnormal_hypodermis_morpholog3.25677028
4MP0010368_abnormal_lymphatic_system3.07709280
5MP0005257_abnormal_intraocular_pressure2.84900420
6MP0005083_abnormal_biliary_tract2.79975728
7MP0002139_abnormal_hepatobiliary_system2.72176996
8MP0005275_abnormal_skin_tensile2.58498254
9MP0005360_urolithiasis2.36705154
10MP0005623_abnormal_meninges_morphology2.25718298
11MP0005365_abnormal_bile_salt2.16441513
12MP0002877_abnormal_melanocyte_morpholog2.14707528
13MP0004084_abnormal_cardiac_muscle2.14600446
14MP0003950_abnormal_plasma_membrane2.11251886
15MP0001666_abnormal_nutrient_absorption2.10798834
16MP0004858_abnormal_nervous_system2.06476877
17MP0005085_abnormal_gallbladder_physiolo2.01370995
18MP0001958_emphysema1.99609398
19MP0003279_aneurysm1.99332113
20MP0001879_abnormal_lymphatic_vessel1.99303845
21MP0009840_abnormal_foam_cell1.98717425
22MP0010234_abnormal_vibrissa_follicle1.89813911
23MP0000013_abnormal_adipose_tissue1.85663781
24MP0000751_myopathy1.84337395
25MP0000566_synostosis1.83979193
26MP0002249_abnormal_larynx_morphology1.76183501
27MP0005670_abnormal_white_adipose1.74847177
28MP0006138_congestive_heart_failure1.74795189
29MP0005503_abnormal_tendon_morphology1.74772122
30MP0002837_dystrophic_cardiac_calcinosis1.73871381
31MP0004185_abnormal_adipocyte_glucose1.73653326
32MP0005167_abnormal_blood-brain_barrier1.70523094
33MP0000003_abnormal_adipose_tissue1.68617496
34MP0003252_abnormal_bile_duct1.68130797
35MP0001849_ear_inflammation1.67922023
36MP0005409_darkened_coat_color1.63778421
37MP0000678_abnormal_parathyroid_gland1.63226336
38MP0005058_abnormal_lysosome_morphology1.61884832
39MP0009384_cardiac_valve_regurgitation1.59497712
40MP0005076_abnormal_cell_differentiation1.59342511
41MP0005666_abnormal_adipose_tissue1.59054537
42MP0005375_adipose_tissue_phenotype1.58076901
43MP0000920_abnormal_myelination1.55709127
44MP0002295_abnormal_pulmonary_circulatio1.54511648
45MP0003566_abnormal_cell_adhesion1.52701375
46MP0004130_abnormal_muscle_cell1.51190064
47MP0006054_spinal_hemorrhage1.50884467
48MP0005330_cardiomyopathy1.49331227
49MP0003806_abnormal_nucleotide_metabolis1.47217181
50MP0009053_abnormal_anal_canal1.43156270
51MP0005501_abnormal_skin_physiology1.41747568
52MP0010329_abnormal_lipoprotein_level1.41589426
53MP0004036_abnormal_muscle_relaxation1.41206777
54MP0000750_abnormal_muscle_regeneration1.36700861
55MP0002138_abnormal_hepatobiliary_system1.35534310
56MP0002089_abnormal_postnatal_growth/wei1.35418696
57MP0000467_abnormal_esophagus_morphology1.33639879
58MP0000749_muscle_degeneration1.33002188
59MP0010352_gastrointestinal_tract_polyps1.32669180
60MP0005332_abnormal_amino_acid1.32369411
61MP0004087_abnormal_muscle_fiber1.31853823
62MP0008875_abnormal_xenobiotic_pharmacok1.30682054
63MP0000534_abnormal_ureter_morphology1.29886339
64MP0002060_abnormal_skin_morphology1.28840052
65MP0008775_abnormal_heart_ventricle1.25345034
66MP0001348_abnormal_lacrimal_gland1.24175485
67MP0000537_abnormal_urethra_morphology1.23597677
68MP0005171_absent_coat_pigmentation1.23554132
69MP0002118_abnormal_lipid_homeostasis1.23171422
70MP0005084_abnormal_gallbladder_morpholo1.22091475
71MP0008004_abnormal_stomach_pH1.21728561
72MP0003191_abnormal_cellular_cholesterol1.21707823
73MP0005385_cardiovascular_system_phenoty1.15654009
74MP0001544_abnormal_cardiovascular_syste1.15654009
75MP0004215_abnormal_myocardial_fiber1.14455635
76MP0002972_abnormal_cardiac_muscle1.13819467
77MP0000747_muscle_weakness1.12488930
78MP0010030_abnormal_orbit_morphology1.11949102
79MP0003329_amyloid_beta_deposits1.10237503
80MP0003690_abnormal_glial_cell1.08946386
81MP0003828_pulmonary_edema1.08073793
82MP0010630_abnormal_cardiac_muscle1.07349858
83MP0003942_abnormal_urinary_system1.06068803
84MP0002796_impaired_skin_barrier1.05142766
85MP0003385_abnormal_body_wall1.05041809
86MP0000767_abnormal_smooth_muscle1.04228368
87MP0003091_abnormal_cell_migration1.03746199
88MP0005165_increased_susceptibility_to1.03606176
89MP0009250_abnormal_appendicular_skeleto1.01880129
90MP0000579_abnormal_nail_morphology1.01749021
91MP0005023_abnormal_wound_healing1.01315232
92MP0005620_abnormal_muscle_contractility1.01242846
93MP0005595_abnormal_vascular_smooth1.00169089
94MP0001542_abnormal_bone_strength0.99967164
95MP0010678_abnormal_skin_adnexa0.99046452
96MP0002108_abnormal_muscle_morphology0.96534970
97MP0000858_altered_metastatic_potential0.94894595
98MP0003300_gastrointestinal_ulcer0.93968265
99MP0000733_abnormal_muscle_development0.93475300
100MP0000462_abnormal_digestive_system0.93276007
101MP0010771_integument_phenotype0.91694910
102MP0003941_abnormal_skin_development0.91212889
103MP0001299_abnormal_eye_distance/0.91196836
104MP0002269_muscular_atrophy0.90716007
105MP0001915_intracranial_hemorrhage0.90582033
106MP0005220_abnormal_exocrine_pancreas0.89961578
107MP0001661_extended_life_span0.88565874
108MP0002128_abnormal_blood_circulation0.86638529
109MP0003137_abnormal_impulse_conducting0.86071742
110MP0001216_abnormal_epidermal_layer0.84878521
111MP0002932_abnormal_joint_morphology0.81962394
112MP0000759_abnormal_skeletal_muscle0.80779547
113MP0005451_abnormal_body_composition0.79754844
114MP0002282_abnormal_trachea_morphology0.79166663
115MP0005508_abnormal_skeleton_morphology0.78852286
116MP0000383_abnormal_hair_follicle0.76712817
117MP0002896_abnormal_bone_mineralization0.75198302
118MP0003453_abnormal_keratinocyte_physiol0.74661002
119MP0004085_abnormal_heartbeat0.74268209
120MP0009643_abnormal_urine_homeostasis0.73608192
121MP0001614_abnormal_blood_vessel0.73561358
122MP0002098_abnormal_vibrissa_morphology0.73174883
123MP0000163_abnormal_cartilage_morphology0.73020157
124MP0003045_fibrosis0.72909390
125MP0003195_calcinosis0.72644086
126MP0000609_abnormal_liver_physiology0.71844093
127MP0003115_abnormal_respiratory_system0.71021489
128MP0001243_abnormal_dermal_layer0.70971177
129MP0000049_abnormal_middle_ear0.70949261
130MP0005164_abnormal_response_to0.70754372
131MP0005197_abnormal_uvea_morphology0.70742168
132MP0009780_abnormal_chondrocyte_physiolo0.70376848
133MP0004782_abnormal_surfactant_physiolog0.70270822
134MP0005388_respiratory_system_phenotype0.69849900
135MP0002133_abnormal_respiratory_system0.69849900
136MP0000647_abnormal_sebaceous_gland0.69000914
137MP0000428_abnormal_craniofacial_morphol0.68364680
138MP0004233_abnormal_muscle_weight0.66568975
139MP0008260_abnormal_autophagy0.66559685
140MP0000762_abnormal_tongue_morphology0.66162279
141MP0002933_joint_inflammation0.65765385
142MP0000681_abnormal_thyroid_gland0.65424582
143MP0000432_abnormal_head_morphology0.65140375
144MP0002925_abnormal_cardiovascular_devel0.64498602
145MP0005390_skeleton_phenotype0.63850851
146MP0002116_abnormal_craniofacial_bone0.63603150

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.96334576
2Protrusio acetabuli (HP:0003179)4.21589500
3Broad metatarsal (HP:0001783)4.02999871
4Muscle fiber splitting (HP:0003555)3.91934575
5Ulnar bowing (HP:0003031)3.57065828
6Deep venous thrombosis (HP:0002625)3.56213611
7Right ventricular cardiomyopathy (HP:0011663)3.51017197
8Shallow orbits (HP:0000586)3.28229572
9Hyporeflexia of lower limbs (HP:0002600)3.19410519
10Increased connective tissue (HP:0009025)3.17744096
11Vertebral compression fractures (HP:0002953)3.13877465
12Vascular tortuosity (HP:0004948)3.10491054
13Cervical subluxation (HP:0003308)3.02158844
14Xanthomatosis (HP:0000991)2.96871179
15Arterial tortuosity (HP:0005116)2.87268791
16Distal upper limb amyotrophy (HP:0007149)2.87201829
17Upper limb amyotrophy (HP:0009129)2.87201829
18Ankle contracture (HP:0006466)2.84438065
19Neonatal short-limb short stature (HP:0008921)2.81306528
20Fragile skin (HP:0001030)2.72751030
21Atrophic scars (HP:0001075)2.70111307
22Ventricular tachycardia (HP:0004756)2.68562386
23Hyperacusis (HP:0010780)2.68209498
24Increased variability in muscle fiber diameter (HP:0003557)2.66624425
25Spinal rigidity (HP:0003306)2.65224918
26Difficulty running (HP:0009046)2.64684705
27Mitral regurgitation (HP:0001653)2.60997890
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60004972
29Cerebral aneurysm (HP:0004944)2.56274859
30Intrahepatic cholestasis (HP:0001406)2.55471233
31Biconcave vertebral bodies (HP:0004586)2.50787501
32Aortic dissection (HP:0002647)2.50197297
33Sudden death (HP:0001699)2.50175727
34Hyperlipoproteinemia (HP:0010980)2.45040398
35Elbow flexion contracture (HP:0002987)2.44950725
36Genu recurvatum (HP:0002816)2.44697539
37Abnormality of serine family amino acid metabolism (HP:0010894)2.44330243
38Abnormality of glycine metabolism (HP:0010895)2.44330243
39Ileus (HP:0002595)2.41464239
40Polycythemia (HP:0001901)2.40777394
41Coronal craniosynostosis (HP:0004440)2.38838932
42Distal lower limb amyotrophy (HP:0008944)2.37858516
43Nonimmune hydrops fetalis (HP:0001790)2.36707137
44Obstructive sleep apnea (HP:0002870)2.35216146
45Peritonitis (HP:0002586)2.34458917
46Lymphangioma (HP:0100764)2.32557545
47Cerebral hemorrhage (HP:0001342)2.30590137
48Esophageal varix (HP:0002040)2.25928234
49Short nail (HP:0001799)2.24353180
50Bowed forearm bones (HP:0003956)2.21408987
51Bowing of the arm (HP:0006488)2.21408987
52Abnormality of the distal phalanges of the toes (HP:0010182)2.21398330
53Dilatation of the ascending aorta (HP:0005111)2.21003529
54Cardiovascular calcification (HP:0011915)2.19558210
55Abnormality of skeletal muscle fiber size (HP:0012084)2.18982137
56Hypoalphalipoproteinemia (HP:0003233)2.18784885
57Broad face (HP:0000283)2.18291491
58Type 1 muscle fiber predominance (HP:0003803)2.17372853
59Hyperammonemia (HP:0001987)2.17092836
60Generalized amyotrophy (HP:0003700)2.16604502
61Neurofibrillary tangles (HP:0002185)2.16485117
62Bladder diverticulum (HP:0000015)2.14136425
63Difficulty climbing stairs (HP:0003551)2.13829013
64Abnormality of the acetabulum (HP:0003170)2.13227315
65Lipoatrophy (HP:0100578)2.13216859
66Hyperglycinuria (HP:0003108)2.11469016
67Acanthosis nigricans (HP:0000956)2.10239271
68Distal lower limb muscle weakness (HP:0009053)2.10096478
69Visceral angiomatosis (HP:0100761)2.09974418
70Ketosis (HP:0001946)2.09836884
71Aplasia involving bones of the extremities (HP:0009825)2.09270476
72Aplasia involving bones of the upper limbs (HP:0009823)2.09270476
73Aplasia of the phalanges of the hand (HP:0009802)2.09270476
74Onion bulb formation (HP:0003383)2.08667556
75Hand muscle atrophy (HP:0009130)2.07029836
76Premature skin wrinkling (HP:0100678)2.06225129
77Thin bony cortex (HP:0002753)2.06110836
78Axonal loss (HP:0003447)2.06088527
79Joint stiffness (HP:0001387)2.05040556
80Soft skin (HP:0000977)2.04047992
81Turricephaly (HP:0000262)2.03055520
82Joint laxity (HP:0001388)2.02293578
83EMG: myopathic abnormalities (HP:0003458)2.00228025
84Trismus (HP:0000211)1.99542354
85Infantile muscular hypotonia (HP:0008947)1.99294826
86Mitral stenosis (HP:0001718)1.97809733
87Bronchomalacia (HP:0002780)1.96195145
88Abnormal delivery (HP:0001787)1.95751240
89Blue sclerae (HP:0000592)1.95257144
90Buphthalmos (HP:0000557)1.95158434
91Stridor (HP:0010307)1.94563514
92Gout (HP:0001997)1.93637468
93Abnormality of complement system (HP:0005339)1.93582424
94Cerebral inclusion bodies (HP:0100314)1.93084739
95Natal tooth (HP:0000695)1.92756716
96Abnormality of the Achilles tendon (HP:0005109)1.92360203
97Mildly elevated creatine phosphokinase (HP:0008180)1.91990751
98Abnormality of fatty-acid metabolism (HP:0004359)1.91204649
99Coxa vara (HP:0002812)1.91105734
100Ventricular fibrillation (HP:0001663)1.90683816
101Vascular calcification (HP:0004934)1.90565748
102Hypoglycemic coma (HP:0001325)1.90270630
103Hypoplasia of the iris (HP:0007676)1.90244010
104Abnormality of carpal bone ossification (HP:0006257)1.89360914
105Thin ribs (HP:0000883)1.89159345
106Hemangiomatosis (HP:0007461)1.87943396
107Abnormal ossification of hand bones (HP:0005921)1.87446100
108Renal duplication (HP:0000075)1.87028327
109Hyperglycinemia (HP:0002154)1.86783929
110Wormian bones (HP:0002645)1.85754651
111Focal segmental glomerulosclerosis (HP:0000097)1.85689266
112Aortic aneurysm (HP:0004942)1.85605205
113Myocardial infarction (HP:0001658)1.85499599
114Aneurysm (HP:0002617)1.85121822
115Short hallux (HP:0010109)1.84782728
116Advanced eruption of teeth (HP:0006288)1.84777113
117Achilles tendon contracture (HP:0001771)1.84339436
118Scapular winging (HP:0003691)1.83971581
119Hyperextensible skin (HP:0000974)1.83748580
120Neonatal death (HP:0003811)1.83033190
121Mitral valve prolapse (HP:0001634)1.82362708
122Glomerulosclerosis (HP:0000096)1.82051231
123Dilated cardiomyopathy (HP:0001644)1.81996373
124Ketoacidosis (HP:0001993)1.81641490
125Atrial fibrillation (HP:0005110)1.81276317
126Aortic regurgitation (HP:0001659)1.80740869
127Round ear (HP:0100830)1.80680220
128Insomnia (HP:0100785)1.80362413
129Bowel diverticulosis (HP:0005222)1.79593895
130Mesangial abnormality (HP:0001966)1.79112110
131Abnormality of the umbilical cord (HP:0010881)1.77637000
132Slender build (HP:0001533)1.77392624
133Segmental peripheral demyelination/remyelination (HP:0003481)1.77355713
134Abnormality of dentin (HP:0010299)1.77176507
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.77016101
136Osteolytic defects of the hand bones (HP:0009699)1.77016101
137Follicular hyperkeratosis (HP:0007502)1.76507368
138Ectopia lentis (HP:0001083)1.75260455
139Hemorrhage of the eye (HP:0011885)1.75004630
140Myoglobinuria (HP:0002913)1.74454511
141Venous abnormality (HP:0002624)1.72676739
142Flat acetabular roof (HP:0003180)1.72443719
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72358772
144Protruding ear (HP:0000411)1.71570897
145Complement deficiency (HP:0004431)1.71265237
146Pterygium (HP:0001059)1.70595950
147Lower limb amyotrophy (HP:0007210)1.69945014
148Foot dorsiflexor weakness (HP:0009027)1.69730704
149Aplasia/Hypoplasia of the hallux (HP:0008362)1.69303525
150Disproportionate tall stature (HP:0001519)1.68775723
151Wide anterior fontanel (HP:0000260)1.67830461
152Dicarboxylic aciduria (HP:0003215)1.67656804
153Spinal cord compression (HP:0002176)1.67351194
154Venous insufficiency (HP:0005293)1.65766768
155Spondylolisthesis (HP:0003302)1.63596101
156Congenital glaucoma (HP:0001087)1.62993529
157Thin skin (HP:0000963)1.60557447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.04787537
2TRIB33.56801502
3STK393.03419384
4EPHB12.95792050
5TTN2.82055023
6BCKDK2.81815729
7KDR2.74713553
8IRAK32.66722455
9ERN12.49242373
10SMG12.30169571
11MET2.27144281
12SIK12.01559251
13FGFR22.00501243
14LMTK22.00268502
15WNK41.94784695
16PDGFRA1.92212764
17RIPK11.87097329
18PKN21.78063798
19EPHB21.73819448
20NME21.72694295
21DDR21.66838230
22EPHA21.65755519
23FER1.62732820
24TGFBR21.59513963
25OXSR11.59300606
26EEF2K1.57576030
27PTK61.55148320
28LATS11.50701352
29CDK121.45692253
30DMPK1.44741090
31STK381.44598814
32LATS21.44133840
33PAK31.40472060
34MYLK1.35983709
35PTK21.30894114
36PRKD11.30416851
37MAP2K21.28969174
38FGFR41.18402127
39LIMK11.17215102
40TESK21.15949815
41ROCK21.14715794
42PTK2B1.13674563
43PAK21.13005412
44ILK1.12976779
45PRKD31.11437704
46PIK3CA1.11316861
47PRPF4B1.10989831
48PDK21.09367081
49BCR1.09210469
50MST1R1.08987301
51ARAF1.08130975
52PKN11.07634388
53LRRK21.03844105
54NTRK11.02823076
55PHKG11.00590843
56PHKG21.00590843
57CDC42BPA0.99813752
58BMX0.99019518
59MAP2K10.98007919
60PDGFRB0.95018257
61TAOK20.93314381
62WNK10.91351274
63PAK40.89653936
64PRKG20.87541287
65ICK0.87448496
66PIM20.87317041
67MAP3K60.86555087
68ROCK10.84586248
69CAMK2D0.82695633
70RPS6KA20.80349548
71CAMK1D0.79478716
72CDK80.76781440
73TYRO30.76159429
74PDK40.74311812
75PDK30.74311812
76GSK3A0.73924340
77PAK60.71803925
78TRPM70.69994662
79MOS0.69738758
80CAMK2G0.68616537
81CSNK1A1L0.67811408
82FGFR10.66693752
83MAPKAPK30.66620083
84DAPK30.65309346
85MTOR0.65244829
86MAPKAPK50.65132151
87MAP3K80.63116059
88CAMK2B0.62865940
89MAP3K20.62631215
90PDPK10.62120926
91PRKCH0.60821938
92KSR20.58209038
93BRAF0.57617136
94ERBB40.56583752
95MAP3K70.55799272
96CDK70.54829038
97RET0.54596530
98STK38L0.53053211
99ERBB20.49426898
100CAMK1G0.49250905
101MAPK120.48769586
102BRSK10.47232699
103PRKAA20.47117905
104HIPK20.47074205
105CSNK1G30.44798081
106PAK10.44535262
107CSNK1G10.43413629
108DYRK1B0.42607806
109MAP3K30.42537245
110MAP2K30.42277966
111MAPK110.41492371
112MELK0.40549978
113AKT20.40214527
114TGFBR10.40126400
115PRKCE0.38493889
116SRC0.38444179
117MUSK0.37874785
118TESK10.37525858
119MARK20.37516159
120NEK90.37513867
121RPS6KC10.36101654
122RPS6KL10.36101654
123MAPK150.35969402
124PRKD20.35328579
125ABL20.35054038
126MAPKAPK20.33673489
127OBSCN0.33371863
128PRKCI0.32697813
129MAP3K110.31934158
130MAP3K10.30925832
131IRAK20.30630767
132CDK11A0.27775496
133NEK20.27594425
134CDK150.26370716

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.62693163
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66497389
3Propanoate metabolism_Homo sapiens_hsa006402.56321677
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50577686
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.42311103
6Fatty acid degradation_Homo sapiens_hsa000712.36951516
7Fatty acid elongation_Homo sapiens_hsa000622.27998398
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23673221
9Fatty acid metabolism_Homo sapiens_hsa012122.20169526
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18755556
11Sulfur relay system_Homo sapiens_hsa041222.14166389
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06560166
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.05241296
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.02796663
15Fat digestion and absorption_Homo sapiens_hsa049751.98897017
16Arginine biosynthesis_Homo sapiens_hsa002201.98379552
17PPAR signaling pathway_Homo sapiens_hsa033201.98033321
18ECM-receptor interaction_Homo sapiens_hsa045121.83448900
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78915278
20Steroid biosynthesis_Homo sapiens_hsa001001.76625388
21Butanoate metabolism_Homo sapiens_hsa006501.74863719
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69368194
23Protein digestion and absorption_Homo sapiens_hsa049741.68286554
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64027976
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.62796034
26Other glycan degradation_Homo sapiens_hsa005111.60991235
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.56928490
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56334225
29Notch signaling pathway_Homo sapiens_hsa043301.56022784
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55694185
31Tryptophan metabolism_Homo sapiens_hsa003801.55648466
32Galactose metabolism_Homo sapiens_hsa000521.51142130
33Chronic myeloid leukemia_Homo sapiens_hsa052201.45486847
34Fructose and mannose metabolism_Homo sapiens_hsa000511.43625823
35Arginine and proline metabolism_Homo sapiens_hsa003301.42038077
36Complement and coagulation cascades_Homo sapiens_hsa046101.38091313
37Vitamin B6 metabolism_Homo sapiens_hsa007501.37837318
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37116442
39Pyruvate metabolism_Homo sapiens_hsa006201.33481445
40Carbon metabolism_Homo sapiens_hsa012001.31990264
41Pancreatic secretion_Homo sapiens_hsa049721.30369141
42Sulfur metabolism_Homo sapiens_hsa009201.26997222
43beta-Alanine metabolism_Homo sapiens_hsa004101.26613902
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21922169
45Focal adhesion_Homo sapiens_hsa045101.21658798
46Glycerolipid metabolism_Homo sapiens_hsa005611.21432796
47Tight junction_Homo sapiens_hsa045301.20254582
48Histidine metabolism_Homo sapiens_hsa003401.19799817
49Dilated cardiomyopathy_Homo sapiens_hsa054141.19637224
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16772582
51Peroxisome_Homo sapiens_hsa041461.15666804
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15166898
53Bile secretion_Homo sapiens_hsa049761.14747804
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11231296
55Vibrio cholerae infection_Homo sapiens_hsa051101.08362828
56Fatty acid biosynthesis_Homo sapiens_hsa000611.07655327
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07620384
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05695783
59Biosynthesis of amino acids_Homo sapiens_hsa012301.05247728
60N-Glycan biosynthesis_Homo sapiens_hsa005101.03546022
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03315450
62Caffeine metabolism_Homo sapiens_hsa002321.00737478
63VEGF signaling pathway_Homo sapiens_hsa043700.98320737
64Thyroid cancer_Homo sapiens_hsa052160.97409198
65Pancreatic cancer_Homo sapiens_hsa052120.96976698
66MicroRNAs in cancer_Homo sapiens_hsa052060.95729823
67Glioma_Homo sapiens_hsa052140.95696422
68Chemical carcinogenesis_Homo sapiens_hsa052040.95690858
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94698715
70Folate biosynthesis_Homo sapiens_hsa007900.94214303
71Vitamin digestion and absorption_Homo sapiens_hsa049770.93738542
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93427650
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90724879
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89430834
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87203765
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82916456
77Melanogenesis_Homo sapiens_hsa049160.82266676
78Insulin signaling pathway_Homo sapiens_hsa049100.80500722
79Sphingolipid metabolism_Homo sapiens_hsa006000.79436373
80Amoebiasis_Homo sapiens_hsa051460.74078034
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72362113
82Proteoglycans in cancer_Homo sapiens_hsa052050.70790190
83Glutathione metabolism_Homo sapiens_hsa004800.70122324
84Phenylalanine metabolism_Homo sapiens_hsa003600.70001347
85Bladder cancer_Homo sapiens_hsa052190.68934655
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68376790
87Tyrosine metabolism_Homo sapiens_hsa003500.67686362
88Retinol metabolism_Homo sapiens_hsa008300.67399989
89Adherens junction_Homo sapiens_hsa045200.67151299
90Estrogen signaling pathway_Homo sapiens_hsa049150.67137837
91TGF-beta signaling pathway_Homo sapiens_hsa043500.65612276
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65496340
93ErbB signaling pathway_Homo sapiens_hsa040120.65119460
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.63966019
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.63906139
96Pathways in cancer_Homo sapiens_hsa052000.63586254
97Melanoma_Homo sapiens_hsa052180.63123854
98Acute myeloid leukemia_Homo sapiens_hsa052210.62614597
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.62302350
100Thyroid hormone synthesis_Homo sapiens_hsa049180.62233806
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.62151807
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.61770630
103Endometrial cancer_Homo sapiens_hsa052130.61323712
104GnRH signaling pathway_Homo sapiens_hsa049120.61113133
105Axon guidance_Homo sapiens_hsa043600.60091027
106Starch and sucrose metabolism_Homo sapiens_hsa005000.57814112
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57688416
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.57068639
109Renal cell carcinoma_Homo sapiens_hsa052110.56400259
110Hippo signaling pathway_Homo sapiens_hsa043900.56358160
111Wnt signaling pathway_Homo sapiens_hsa043100.56282981
112Non-small cell lung cancer_Homo sapiens_hsa052230.55907962
113Lysosome_Homo sapiens_hsa041420.55836711
114Small cell lung cancer_Homo sapiens_hsa052220.52985796
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52729792
116Gap junction_Homo sapiens_hsa045400.50774586
117Glucagon signaling pathway_Homo sapiens_hsa049220.50377540
118AMPK signaling pathway_Homo sapiens_hsa041520.50360773
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49834353
120Lysine degradation_Homo sapiens_hsa003100.48345699
121Prostate cancer_Homo sapiens_hsa052150.46782215
122Cardiac muscle contraction_Homo sapiens_hsa042600.45718193
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44788313
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44676551
125Insulin resistance_Homo sapiens_hsa049310.44202605
126mTOR signaling pathway_Homo sapiens_hsa041500.43480955
127Rap1 signaling pathway_Homo sapiens_hsa040150.42234325
128Linoleic acid metabolism_Homo sapiens_hsa005910.42195558
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42166697
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.40131173
131Selenocompound metabolism_Homo sapiens_hsa004500.39308062
132ABC transporters_Homo sapiens_hsa020100.38980948
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35749076
134Pentose phosphate pathway_Homo sapiens_hsa000300.35146064
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35014290
136Basal cell carcinoma_Homo sapiens_hsa052170.34735815
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33529166
138Maturity onset diabetes of the young_Homo sapiens_hsa049500.32589546
139Ovarian steroidogenesis_Homo sapiens_hsa049130.32570942
140Prion diseases_Homo sapiens_hsa050200.32553181
141Ether lipid metabolism_Homo sapiens_hsa005650.31269192
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30573858
143Viral myocarditis_Homo sapiens_hsa054160.30064644
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.29587322
145Hedgehog signaling pathway_Homo sapiens_hsa043400.27782940
146Endocytosis_Homo sapiens_hsa041440.26905992

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