CDC34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.81795103
2folic acid-containing compound biosynthetic process (GO:0009396)4.53955285
3formation of translation preinitiation complex (GO:0001731)4.34902404
4regulation of gene silencing by RNA (GO:0060966)4.31259898
5regulation of posttranscriptional gene silencing (GO:0060147)4.31259898
6regulation of gene silencing by miRNA (GO:0060964)4.31259898
73-UTR-mediated mRNA stabilization (GO:0070935)4.28466294
8protein localization to endosome (GO:0036010)4.18127641
9viral transcription (GO:0019083)4.17604964
10regulation of early endosome to late endosome transport (GO:2000641)4.13888190
11translational termination (GO:0006415)4.09896470
12maturation of SSU-rRNA (GO:0030490)4.08398346
13protoporphyrinogen IX metabolic process (GO:0046501)4.05962942
14DNA unwinding involved in DNA replication (GO:0006268)3.96261655
15regulation of mammary gland epithelial cell proliferation (GO:0033599)3.93209346
16DNA deamination (GO:0045006)3.92737476
17apoptotic process involved in morphogenesis (GO:0060561)3.88688886
18nucleobase biosynthetic process (GO:0046112)3.87344390
19translational elongation (GO:0006414)3.83646267
20translational initiation (GO:0006413)3.82984624
21DNA strand elongation involved in DNA replication (GO:0006271)3.82619439
22protein localization to kinetochore (GO:0034501)3.81620391
23mitotic nuclear envelope disassembly (GO:0007077)3.74595389
24DNA replication-dependent nucleosome organization (GO:0034723)3.74524893
25DNA replication-dependent nucleosome assembly (GO:0006335)3.74524893
26ribosomal large subunit biogenesis (GO:0042273)3.71477267
27negative regulation of erythrocyte differentiation (GO:0045647)3.70986614
28modulation by virus of host process (GO:0019054)3.70780125
29IMP biosynthetic process (GO:0006188)3.68849626
30modulation by symbiont of host cellular process (GO:0044068)3.67112236
31mitotic metaphase plate congression (GO:0007080)3.62823788
32heterochromatin organization (GO:0070828)3.62372667
33folic acid metabolic process (GO:0046655)3.61299888
34ribosomal small subunit biogenesis (GO:0042274)3.61134286
35DNA strand elongation (GO:0022616)3.59642588
36* DNA replication initiation (GO:0006270)3.56269221
37positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.56185699
38DNA replication checkpoint (GO:0000076)3.53929670
39ribosomal small subunit assembly (GO:0000028)3.53346592
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50266327
41purine nucleobase biosynthetic process (GO:0009113)3.48375270
42nuclear envelope disassembly (GO:0051081)3.45662113
43membrane disassembly (GO:0030397)3.45662113
44ribonucleoprotein complex biogenesis (GO:0022613)3.45098510
45oxygen transport (GO:0015671)3.42739947
46protein localization to chromosome, centromeric region (GO:0071459)3.42680542
47tooth mineralization (GO:0034505)3.42674558
48ribosome biogenesis (GO:0042254)3.41859777
49ribosome assembly (GO:0042255)3.38664633
50IMP metabolic process (GO:0046040)3.38017242
51telomere maintenance via semi-conservative replication (GO:0032201)3.36669571
52protoporphyrinogen IX biosynthetic process (GO:0006782)3.35388473
53regulation of translational fidelity (GO:0006450)3.34237389
54proline biosynthetic process (GO:0006561)3.33995212
55nuclear pore organization (GO:0006999)3.31831000
56regulation of chromatin binding (GO:0035561)3.31250589
57negative regulation of necroptotic process (GO:0060546)3.28893435
58pentose metabolic process (GO:0019321)3.25599817
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22916431
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22754027
61regulation of translational termination (GO:0006449)3.20871121
62cellular protein complex disassembly (GO:0043624)3.20578279
63creatine metabolic process (GO:0006600)3.19194849
64hemoglobin metabolic process (GO:0020027)3.17649608
65pentose-phosphate shunt (GO:0006098)3.16418134
66viral life cycle (GO:0019058)3.15543234
67protein retention in ER lumen (GO:0006621)3.14503561
68protein targeting to ER (GO:0045047)3.13982773
69intracellular estrogen receptor signaling pathway (GO:0030520)3.13152381
70cotranslational protein targeting to membrane (GO:0006613)3.10965157
71mitotic sister chromatid segregation (GO:0000070)3.09865781
72spliceosomal snRNP assembly (GO:0000387)3.09050937
73rRNA processing (GO:0006364)3.08227088
74planar cell polarity pathway involved in neural tube closure (GO:0090179)3.04025396
75cellular response to virus (GO:0098586)3.03030632
76nuclear pore complex assembly (GO:0051292)3.02991294
77positive regulation of Cdc42 GTPase activity (GO:0043089)3.02510254
78glycine metabolic process (GO:0006544)3.01149721
79paraxial mesoderm development (GO:0048339)3.01066314
80regulation of response to osmotic stress (GO:0047484)3.00779816
81rRNA metabolic process (GO:0016072)2.99399500
82pteridine-containing compound biosynthetic process (GO:0042559)2.98922039
83protein complex disassembly (GO:0043241)2.98747582
84establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97843763
85adherens junction assembly (GO:0034333)2.97718154
86protein targeting to plasma membrane (GO:0072661)2.96088724
87positive regulation by symbiont of host defense response (GO:0052509)2.92797813
88modulation by symbiont of host defense response (GO:0052031)2.92797813
89modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92797813
90modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92797813
91positive regulation by organism of defense response of other organism involved in symbiotic interact2.92797813
92modulation by symbiont of host immune response (GO:0052553)2.92797813
93heme biosynthetic process (GO:0006783)2.92368027
94protein localization to endoplasmic reticulum (GO:0070972)2.92231492
95barbed-end actin filament capping (GO:0051016)2.92099995
96cell-substrate adherens junction assembly (GO:0007045)2.91959333
97focal adhesion assembly (GO:0048041)2.91959333
98metaphase plate congression (GO:0051310)2.90656851
99RNA stabilization (GO:0043489)2.90342164
100mRNA stabilization (GO:0048255)2.90342164
101chaperone-mediated protein complex assembly (GO:0051131)2.90124276
102negative regulation of cell size (GO:0045792)2.89129898
103maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88771597
104viral protein processing (GO:0019082)2.87975911
105erythrocyte maturation (GO:0043249)2.87746503
106peptidyl-arginine omega-N-methylation (GO:0035247)2.85522426
107telomere maintenance via recombination (GO:0000722)2.84905803
108translation (GO:0006412)2.84650567
109regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.83884591
110regulation of spindle organization (GO:0090224)2.83555214
111gas transport (GO:0015669)2.83266734
112protein complex localization (GO:0031503)2.83253743
113pre-miRNA processing (GO:0031054)2.82905423
114porphyrin-containing compound biosynthetic process (GO:0006779)2.81763229
115protein maturation by protein folding (GO:0022417)2.81447879
116tetrahydrofolate metabolic process (GO:0046653)2.81419635
117modulation by virus of host morphology or physiology (GO:0019048)2.80952173
118macromolecular complex disassembly (GO:0032984)2.80152589
119histone arginine methylation (GO:0034969)2.79592140
120nuclear envelope organization (GO:0006998)2.78450146
121activation of MAPKKK activity (GO:0000185)2.78318893
122peptidyl-arginine N-methylation (GO:0035246)2.76219519
123peptidyl-arginine methylation (GO:0018216)2.76219519
124telomere maintenance via telomere lengthening (GO:0010833)2.75133924
125glucose 6-phosphate metabolic process (GO:0051156)2.74776329
126positive regulation of chromosome segregation (GO:0051984)2.72854481
127virion assembly (GO:0019068)2.70807544
128negative regulation of myotube differentiation (GO:0010832)2.70445224
129pseudouridine synthesis (GO:0001522)2.70216300
130regulation of hippo signaling (GO:0035330)2.69480999
131negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.68741412
132regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.67907482
133mitochondrial DNA metabolic process (GO:0032042)2.67290817
134NADPH regeneration (GO:0006740)2.66064963
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65412802
136DNA duplex unwinding (GO:0032508)2.63925694
137glucose catabolic process (GO:0006007)2.63377249
138nuclear-transcribed mRNA catabolic process (GO:0000956)2.63350018
139mitotic recombination (GO:0006312)2.62933592
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.62732587
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62732587
142DNA geometric change (GO:0032392)2.62363134
143chromatin assembly (GO:0031497)2.62287374
144folic acid-containing compound metabolic process (GO:0006760)2.62074933
145negative regulation of translational initiation (GO:0045947)2.61941345
146embryonic process involved in female pregnancy (GO:0060136)2.61813700
147cellular hyperosmotic response (GO:0071474)2.61736123
148stress fiber assembly (GO:0043149)2.61502507
149GDP-mannose metabolic process (GO:0019673)2.60085219
150sister chromatid segregation (GO:0000819)2.59558741
151positive regulation of SMAD protein import into nucleus (GO:0060391)2.58959608
152chromatin remodeling at centromere (GO:0031055)2.58871068
153mitotic chromosome condensation (GO:0007076)2.57851789
154nucleotide-excision repair, DNA gap filling (GO:0006297)2.57642965
155maternal placenta development (GO:0001893)2.57618829
156negative regulation of necrotic cell death (GO:0060547)2.57486262
157RNA catabolic process (GO:0006401)2.57084088
158positive regulation of myotube differentiation (GO:0010831)2.57066041
159pinocytosis (GO:0006907)2.56791864
160mitotic G1 DNA damage checkpoint (GO:0031571)2.55932426
161protein K6-linked ubiquitination (GO:0085020)2.55739643
162amyloid precursor protein catabolic process (GO:0042987)2.55182189
163establishment of chromosome localization (GO:0051303)2.54907158
164cell-cell junction maintenance (GO:0045217)2.54755788
165regulation of necroptotic process (GO:0060544)2.54675165
166regulation of mitotic spindle organization (GO:0060236)2.54478510
167cellular protein complex localization (GO:0034629)2.53631123
168trophectodermal cell differentiation (GO:0001829)2.53453302
169basement membrane organization (GO:0071711)2.52549155
170negative regulation of striated muscle cell differentiation (GO:0051154)2.52385626
171interferon-gamma secretion (GO:0072643)2.51496800
172regulation of necrotic cell death (GO:0010939)2.50811581
173intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.50411016
174anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49344607
175mRNA catabolic process (GO:0006402)2.49002643
176apoptotic process involved in development (GO:1902742)2.47862007
177positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.47081286
178negative regulation of glial cell proliferation (GO:0060253)2.46818494
179regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.46649243
180positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.46649243
181regulation of ARF GTPase activity (GO:0032312)2.45254582
182nucleosome disassembly (GO:0006337)2.44781024
183protein-DNA complex disassembly (GO:0032986)2.44781024
184retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.44317816
185protein insertion into membrane (GO:0051205)2.43817073
186respiratory system process (GO:0003016)2.43477492
187erythrocyte development (GO:0048821)2.42985137
188muscle cell fate commitment (GO:0042693)2.42745917
189deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.41752324
190heme metabolic process (GO:0042168)2.40095022
191proline metabolic process (GO:0006560)2.39795541
192protein export from nucleus (GO:0006611)2.39721735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.07344106
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.94447177
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76628715
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.45561080
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94778234
6* LXR_22292898_ChIP-Seq_THP-1_Human2.67455180
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63165293
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58898612
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56852648
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52801188
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52260295
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.40060266
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31470212
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26061873
15* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25387723
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21473637
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17088051
18XRN2_22483619_ChIP-Seq_HELA_Human2.16511084
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.12663538
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09087819
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03574129
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03470912
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02488186
24* KDM2B_26808549_Chip-Seq_DND41_Human2.00820049
25RACK7_27058665_Chip-Seq_MCF-7_Human2.00558076
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.96291112
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.95856877
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94611145
29TCF7_22412390_ChIP-Seq_EML_Mouse1.89135379
30KDM2B_26808549_Chip-Seq_K562_Human1.87282222
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.84831445
32MYC_22102868_ChIP-Seq_BL_Human1.84509696
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84303881
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82931045
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81867509
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80903363
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80134552
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77959448
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75174049
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.74515703
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72724848
42DCP1A_22483619_ChIP-Seq_HELA_Human1.72543352
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69569475
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67662383
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66898098
46* P68_20966046_ChIP-Seq_HELA_Human1.65158765
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60764256
48AR_21909140_ChIP-Seq_LNCAP_Human1.60592906
49* GABP_19822575_ChIP-Seq_HepG2_Human1.58937070
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58736022
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58237737
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.58129922
53VDR_23849224_ChIP-Seq_CD4+_Human1.57780749
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.57649398
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56577902
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52139396
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51926892
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50440364
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49007898
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48949563
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48949563
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48949563
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48609813
64TTF2_22483619_ChIP-Seq_HELA_Human1.48433180
65ZNF263_19887448_ChIP-Seq_K562_Human1.48376714
66* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48122939
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47027350
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.46701103
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.43428421
70FOXP3_21729870_ChIP-Seq_TREG_Human1.43225212
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.42682090
72* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41951678
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.40579128
74KDM5A_27292631_Chip-Seq_BREAST_Human1.38489154
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38170625
76SMC4_20622854_ChIP-Seq_HELA_Human1.36284783
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35502717
78NCOR1_26117541_ChIP-Seq_K562_Human1.35241295
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.34639520
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34441273
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34392037
82VDR_21846776_ChIP-Seq_THP-1_Human1.33977900
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32034311
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31133568
85MAF_26560356_Chip-Seq_TH2_Human1.31021595
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30793457
87MAF_26560356_Chip-Seq_TH1_Human1.30563696
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30398701
89VDR_24763502_ChIP-Seq_THP-1_Human1.29815410
90CIITA_25753668_ChIP-Seq_RAJI_Human1.29427479
91* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28594449
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25873830
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24945249
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24327306
95* CREB1_26743006_Chip-Seq_LNCaP_Human1.24003262
96UTX_26944678_Chip-Seq_JUKART_Human1.21246646
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20440374
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20188143
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20117026
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19869638
101* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19772606
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19685294
103* BCOR_27268052_Chip-Seq_Bcells_Human1.19070006
104SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18095001
105* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17511096
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17087813
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16874323
108BCL6_27268052_Chip-Seq_Bcells_Human1.16635813
109* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16221133
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15140411
111DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14500380
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14465469
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13542602
114OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12947214
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.12066497
116SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11869825
117RUNX1_22412390_ChIP-Seq_EML_Mouse1.11221341
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10606137
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10322398
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09896262
121TFEB_21752829_ChIP-Seq_HELA_Human1.09895228
122ATF3_27146783_Chip-Seq_COLON_Human1.09310007
123TP53_22127205_ChIP-Seq_IMR90_Human1.09135362
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08860511
125CTCF_27219007_Chip-Seq_Bcells_Human1.08721767
126* CTCF_21964334_Chip-Seq_Bcells_Human1.08509580
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08223569
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07340581
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06354388
130* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06313083
131NANOG_21062744_ChIP-ChIP_HESCs_Human1.06047867
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05990287
133ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05677637
134PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04514766
135ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04079508
136SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03045856
137RARA_24833708_ChIP-Seq_LIVER_Mouse1.02588220
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02221675
139CTCF_26484167_Chip-Seq_Bcells_Mouse1.01938531
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01848488
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01213956
142* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00133646
143SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99874963
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99688263
145CLOCK_20551151_ChIP-Seq_293T_Human0.99665395
146RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99639361
147CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99079414
148ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97052321
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96400027
150TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95330494
151NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95291543
152E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94140994
153* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92925946
154* ELK3_25401928_ChIP-Seq_HUVEC_Human0.92875140
155POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92620426
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92121053
157SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91988924
158TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91901238
159SRF_21415370_ChIP-Seq_HL-1_Mouse0.91292080
160FOXP1_21924763_ChIP-Seq_HESCs_Human0.89446578
161* YY1_22570637_ChIP-Seq_MALME-3M_Human0.88583670
162SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88024879
163* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86242259
164HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85954344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008260_abnormal_autophagy4.52861207
2MP0003693_abnormal_embryo_hatching4.20766854
3MP0004957_abnormal_blastocyst_morpholog3.77492010
4MP0003111_abnormal_nucleus_morphology3.59343243
5MP0004858_abnormal_nervous_system3.28286775
6MP0003077_abnormal_cell_cycle3.04099605
7MP0010094_abnormal_chromosome_stability2.93180248
8MP0003806_abnormal_nucleotide_metabolis2.89969824
9MP0003303_peritoneal_inflammation2.79833409
10MP0005058_abnormal_lysosome_morphology2.78137180
11MP0003705_abnormal_hypodermis_morpholog2.61676743
12MP0001730_embryonic_growth_arrest2.39734390
13MP0000678_abnormal_parathyroid_gland2.39091202
14MP0010352_gastrointestinal_tract_polyps2.36393901
15MP0003646_muscle_fatigue2.36161146
16MP0008057_abnormal_DNA_replication2.27457896
17MP0003191_abnormal_cellular_cholesterol2.11925354
18MP0008932_abnormal_embryonic_tissue2.04584010
19MP0003453_abnormal_keratinocyte_physiol1.99535108
20MP0000350_abnormal_cell_proliferation1.97772837
21MP0003172_abnormal_lysosome_physiology1.93660785
22MP0002249_abnormal_larynx_morphology1.90209930
23MP0001672_abnormal_embryogenesis/_devel1.84846349
24MP0005380_embryogenesis_phenotype1.84846349
25MP0001697_abnormal_embryo_size1.80164637
26MP0003329_amyloid_beta_deposits1.79193214
27MP0004510_myositis1.78275223
28MP0008058_abnormal_DNA_repair1.77424572
29MP0002877_abnormal_melanocyte_morpholog1.74606831
30MP0010307_abnormal_tumor_latency1.71957968
31MP0000750_abnormal_muscle_regeneration1.71180438
32MP0003984_embryonic_growth_retardation1.70772229
33MP0002088_abnormal_embryonic_growth/wei1.68057282
34MP0008007_abnormal_cellular_replicative1.67236896
35MP0009840_abnormal_foam_cell1.66221768
36MP0003436_decreased_susceptibility_to1.63164971
37MP0010030_abnormal_orbit_morphology1.62693565
38MP0002653_abnormal_ependyma_morphology1.62545303
39MP0002080_prenatal_lethality1.60683585
40MP0002085_abnormal_embryonic_tissue1.59777628
41MP0003567_abnormal_fetal_cardiomyocyte1.58099977
42MP0002086_abnormal_extraembryonic_tissu1.56718318
43MP0004197_abnormal_fetal_growth/weight/1.55817045
44MP0002089_abnormal_postnatal_growth/wei1.55755750
45MP0005076_abnormal_cell_differentiation1.54787299
46MP0002084_abnormal_developmental_patter1.54120391
47MP0002269_muscular_atrophy1.49795242
48MP0003123_paternal_imprinting1.48390980
49MP0004185_abnormal_adipocyte_glucose1.41243047
50MP0000490_abnormal_crypts_of1.39145060
51MP0004133_heterotaxia1.37325607
52MP0005409_darkened_coat_color1.36250494
53MP0003221_abnormal_cardiomyocyte_apopto1.36247690
54MP0005375_adipose_tissue_phenotype1.33114197
55MP0003119_abnormal_digestive_system1.32461074
56MP0000749_muscle_degeneration1.30375248
57MP0004084_abnormal_cardiac_muscle1.28088879
58MP0006036_abnormal_mitochondrial_physio1.28083754
59MP0002132_abnormal_respiratory_system1.26476574
60MP0003566_abnormal_cell_adhesion1.25552949
61MP0003718_maternal_effect1.22532882
62MP0004087_abnormal_muscle_fiber1.21685932
63MP0004233_abnormal_muscle_weight1.21643586
64MP0003300_gastrointestinal_ulcer1.19827191
65MP0003786_premature_aging1.19529330
66MP0005330_cardiomyopathy1.17740332
67MP0005623_abnormal_meninges_morphology1.17619616
68MP0000313_abnormal_cell_death1.17211537
69MP0009053_abnormal_anal_canal1.16782255
70MP0002019_abnormal_tumor_incidence1.16017689
71MP0003186_abnormal_redox_activity1.15787149
72MP0005666_abnormal_adipose_tissue1.11567961
73MP0003941_abnormal_skin_development1.08723085
74MP0000358_abnormal_cell_content/1.08525658
75MP0000733_abnormal_muscle_development1.07529275
76MP0000003_abnormal_adipose_tissue1.06911477
77MP0005464_abnormal_platelet_physiology1.06319946
78MP0005023_abnormal_wound_healing1.06155112
79MP0001849_ear_inflammation1.05368620
80MP0005266_abnormal_metabolism1.04727549
81MP0010630_abnormal_cardiac_muscle1.03893374
82MP0004947_skin_inflammation1.02117849
83MP0000747_muscle_weakness1.01296816
84MP0009672_abnormal_birth_weight1.01092406
85MP0002396_abnormal_hematopoietic_system1.00474388
86MP0004130_abnormal_muscle_cell0.98243361
87MP0005501_abnormal_skin_physiology0.98107579
88MP0002106_abnormal_muscle_physiology0.96324018
89MP0000759_abnormal_skeletal_muscle0.95618877
90MP0009333_abnormal_splenocyte_physiolog0.94303726
91MP0001293_anophthalmia0.93498705
92MP0005451_abnormal_body_composition0.93013335
93MP0000858_altered_metastatic_potential0.92296080
94MP0000604_amyloidosis0.91902482
95MP0005257_abnormal_intraocular_pressure0.90259859
96MP0006035_abnormal_mitochondrial_morpho0.88680149
97MP0002210_abnormal_sex_determination0.88527579
98MP0001545_abnormal_hematopoietic_system0.88417327
99MP0005397_hematopoietic_system_phenotyp0.88417327
100MP0001145_abnormal_male_reproductive0.86525439
101MP0001929_abnormal_gametogenesis0.86103603
102MP0000537_abnormal_urethra_morphology0.86056052
103MP0003075_altered_response_to0.85897374
104MP0003942_abnormal_urinary_system0.85588012
105MP0002254_reproductive_system_inflammat0.85392685
106MP0009278_abnormal_bone_marrow0.84229000
107MP0003879_abnormal_hair_cell0.83507191
108MP0002092_abnormal_eye_morphology0.83317936
109MP0003890_abnormal_embryonic-extraembry0.83308919
110MP0005621_abnormal_cell_physiology0.83026321
111MP0003091_abnormal_cell_migration0.81908387
112MP0000751_myopathy0.81886523
113MP0001348_abnormal_lacrimal_gland0.79161349
114MP0002837_dystrophic_cardiac_calcinosis0.78930639
115MP0002111_abnormal_tail_morphology0.78309688
116MP0004145_abnormal_muscle_electrophysio0.78079352
117MP0010234_abnormal_vibrissa_follicle0.77679578
118MP0009931_abnormal_skin_appearance0.76974600
119MP0001915_intracranial_hemorrhage0.76004392
120MP0008438_abnormal_cutaneous_collagen0.75729872
121MP0000049_abnormal_middle_ear0.75243522
122MP0005670_abnormal_white_adipose0.75200313
123MP0001661_extended_life_span0.74971973
124MP0003634_abnormal_glial_cell0.74166718
125MP0002796_impaired_skin_barrier0.73528294
126MP0000266_abnormal_heart_morphology0.73424761
127MP0009379_abnormal_foot_pigmentation0.71725596
128MP0004859_abnormal_synaptic_plasticity0.71429745
129MP0002127_abnormal_cardiovascular_syste0.70395397
130MP0005083_abnormal_biliary_tract0.70076212
131MP0000681_abnormal_thyroid_gland0.69027315
132MP0004036_abnormal_muscle_relaxation0.68764830
133MP0002332_abnormal_exercise_endurance0.68764542
134MP0008770_decreased_survivor_rate0.68614324
135MP0003279_aneurysm0.68068808
136MP0002419_abnormal_innate_immunity0.68056149
137MP0000598_abnormal_liver_morphology0.67344526
138MP0005384_cellular_phenotype0.67199373
139MP0001727_abnormal_embryo_implantation0.67103909
140MP0004264_abnormal_extraembryonic_tissu0.66210333
141MP0003828_pulmonary_edema0.65711126
142MP0008874_decreased_physiological_sensi0.65222627
143MP0000653_abnormal_sex_gland0.65042524
144MP0003950_abnormal_plasma_membrane0.64226389
145MP0003315_abnormal_perineum_morphology0.64217120
146MP0003656_abnormal_erythrocyte_physiolo0.63964175
147MP0000343_altered_response_to0.63706790
148MP0005025_abnormal_response_to0.63309018
149MP0004272_abnormal_basement_membrane0.63237429

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)3.73089297
2Multiple enchondromatosis (HP:0005701)3.63293310
3Reticulocytopenia (HP:0001896)3.45549017
4Breast hypoplasia (HP:0003187)3.42547531
5Abnormal number of erythroid precursors (HP:0012131)3.39537906
6Rhabdomyolysis (HP:0003201)3.20133068
7Selective tooth agenesis (HP:0001592)3.15677589
8Ependymoma (HP:0002888)3.14304809
9Oral leukoplakia (HP:0002745)3.12115374
10Trismus (HP:0000211)3.08179247
11Exercise-induced muscle cramps (HP:0003710)3.06743970
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.04356574
13Difficulty climbing stairs (HP:0003551)3.00577904
14Hypochromic microcytic anemia (HP:0004840)2.97575261
15Progressive muscle weakness (HP:0003323)2.95853692
16Birth length less than 3rd percentile (HP:0003561)2.93023960
17Truncus arteriosus (HP:0001660)2.86520159
18Abnormality of the heme biosynthetic pathway (HP:0010472)2.84531043
19Hyperacusis (HP:0010780)2.82441797
20Cholelithiasis (HP:0001081)2.77471567
21Muscle fiber inclusion bodies (HP:0100299)2.73778588
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.72657181
23Cholecystitis (HP:0001082)2.72309956
24Abnormal gallbladder physiology (HP:0012438)2.72309956
25Macrocytic anemia (HP:0001972)2.70310892
26Hypochromic anemia (HP:0001931)2.68900382
27Carpal bone hypoplasia (HP:0001498)2.68129968
28Centrally nucleated skeletal muscle fibers (HP:0003687)2.65551035
29Increased connective tissue (HP:0009025)2.65413554
30Muscle fiber splitting (HP:0003555)2.62437349
31Myoglobinuria (HP:0002913)2.61502310
32Adenoma sebaceum (HP:0009720)2.58693001
33Angiofibromas (HP:0010615)2.58693001
34Abnormality of reticulocytes (HP:0004312)2.57046441
35Myopathic facies (HP:0002058)2.55533431
36Vertebral compression fractures (HP:0002953)2.54543143
37Insomnia (HP:0100785)2.54291810
38Premature ovarian failure (HP:0008209)2.53715905
39Long palpebral fissure (HP:0000637)2.45732184
40Absent thumb (HP:0009777)2.44459193
41Rhabdomyosarcoma (HP:0002859)2.42150674
42Abnormality of the anterior horn cell (HP:0006802)2.42023114
43Degeneration of anterior horn cells (HP:0002398)2.42023114
44Nemaline bodies (HP:0003798)2.39512793
45Increased variability in muscle fiber diameter (HP:0003557)2.39387093
46Broad distal phalanx of finger (HP:0009836)2.35366224
47Disproportionate tall stature (HP:0001519)2.34564732
48Colon cancer (HP:0003003)2.34478648
49Ulnar bowing (HP:0003031)2.33969701
50Abnormality of pyrimidine metabolism (HP:0004353)2.33295177
51Polycythemia (HP:0001901)2.33175077
52Hyperthyroidism (HP:0000836)2.33062840
53Deep palmar crease (HP:0006191)2.31933726
54Distal lower limb amyotrophy (HP:0008944)2.31084435
55Achilles tendon contracture (HP:0001771)2.31050083
56Ragged-red muscle fibers (HP:0003200)2.30903301
57Ventricular tachycardia (HP:0004756)2.30764375
58Rough bone trabeculation (HP:0100670)2.30158257
59Patellar aplasia (HP:0006443)2.29588788
60Cerebral hypomyelination (HP:0006808)2.29349133
61Abnormality of the aortic arch (HP:0012303)2.29310261
62Absent radius (HP:0003974)2.28223168
63Eczematoid dermatitis (HP:0000976)2.28112780
64Protrusio acetabuli (HP:0003179)2.25428515
65Abnormal gallbladder morphology (HP:0012437)2.25367542
66Deep venous thrombosis (HP:0002625)2.25281305
67Areflexia of lower limbs (HP:0002522)2.25111967
68Abnormality of skeletal muscle fiber size (HP:0012084)2.24108806
69Pallor (HP:0000980)2.23955884
70Ulnar deviation of the wrist (HP:0003049)2.20798211
71Recurrent bacterial skin infections (HP:0005406)2.20637046
72Aplasia/Hypoplasia of the patella (HP:0006498)2.20521929
73Abnormality of the Achilles tendon (HP:0005109)2.20076399
74Aplasia/hypoplasia of the humerus (HP:0006507)2.14458722
75Congenital malformation of the right heart (HP:0011723)2.13990978
76Double outlet right ventricle (HP:0001719)2.13990978
77Premature rupture of membranes (HP:0001788)2.12327000
78Abnormality of the gallbladder (HP:0005264)2.11763655
79Genu recurvatum (HP:0002816)2.11166422
80Cerebral inclusion bodies (HP:0100314)2.11001258
81Basal cell carcinoma (HP:0002671)2.10277709
82Hypertensive crisis (HP:0100735)2.09996224
83Abdominal situs inversus (HP:0003363)2.09821967
84Abnormality of abdominal situs (HP:0011620)2.09821967
85Neoplasm of the pancreas (HP:0002894)2.09312157
86Upper limb amyotrophy (HP:0009129)2.09103623
87Distal upper limb amyotrophy (HP:0007149)2.09103623
88Calcaneovalgus deformity (HP:0001848)2.08488293
89Aplasia involving forearm bones (HP:0009822)2.07545354
90Absent forearm bone (HP:0003953)2.07545354
91Reticulocytosis (HP:0001923)2.07263742
92Recurrent abscess formation (HP:0002722)2.05963206
93Obstructive lung disease (HP:0006536)2.05946187
94Chronic obstructive pulmonary disease (HP:0006510)2.05946187
95Testicular atrophy (HP:0000029)2.04381993
96Bowel incontinence (HP:0002607)2.03804687
97Cerebral aneurysm (HP:0004944)2.03530953
98Impulsivity (HP:0100710)2.02844132
99Hyporeflexia of lower limbs (HP:0002600)2.02175252
100Secondary amenorrhea (HP:0000869)2.02096833
101Upper motor neuron abnormality (HP:0002127)2.02094470
102Polygenic inheritance (HP:0010982)2.01852595
103Abnormality of the tricuspid valve (HP:0001702)2.00598686
104Abnormality of the thoracic spine (HP:0100711)2.00597350
105Abnormality of the calcaneus (HP:0008364)1.99729392
106Rib fusion (HP:0000902)1.99725486
107Visual hallucinations (HP:0002367)1.98781217
108Obstructive sleep apnea (HP:0002870)1.97685005
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97631243
110Abnormal large intestine physiology (HP:0012700)1.97558531
111Bulbar palsy (HP:0001283)1.97061800
112Rectal prolapse (HP:0002035)1.96593387
113Muscle fibrillation (HP:0010546)1.95963552
114Missing ribs (HP:0000921)1.95885997
115Cellulitis (HP:0100658)1.95175609
116Metaphyseal cupping (HP:0003021)1.94534432
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94267684
118Sudden death (HP:0001699)1.93223901
119Round ear (HP:0100830)1.92759777
120Difficulty running (HP:0009046)1.92736768
121Neoplasm of striated muscle (HP:0009728)1.92315937
122Spastic diplegia (HP:0001264)1.89155794
123Stridor (HP:0010307)1.89042231
124Microretrognathia (HP:0000308)1.88347889
125Abnormality of macrophages (HP:0004311)1.88200028
126Transposition of the great arteries (HP:0001669)1.87490992
127Abnormal connection of the cardiac segments (HP:0011545)1.87490992
128Abnormal ventriculo-arterial connection (HP:0011563)1.87490992
129Distal arthrogryposis (HP:0005684)1.87361735
130Hypercortisolism (HP:0001578)1.86816611
131Deformed tarsal bones (HP:0008119)1.85783498
132Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84543965
133Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84543965
134Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84266074
135Medulloblastoma (HP:0002885)1.84191227
136Diaphragmatic weakness (HP:0009113)1.83229069
137Distal lower limb muscle weakness (HP:0009053)1.82876876
138Exercise-induced myalgia (HP:0003738)1.82864655
139Increased serum ferritin (HP:0003281)1.82407507
140Microcytic anemia (HP:0001935)1.81775176
141Short humerus (HP:0005792)1.81417120
142Biliary tract neoplasm (HP:0100574)1.80960286
143EMG: neuropathic changes (HP:0003445)1.80591031
144Atresia of the external auditory canal (HP:0000413)1.79532351
145Type 1 muscle fiber predominance (HP:0003803)1.77844611
146Squamous cell carcinoma (HP:0002860)1.77838560
147Pelvic girdle muscle weakness (HP:0003749)1.77723665
148Abnormal hemoglobin (HP:0011902)1.77489927
149Hemorrhage of the eye (HP:0011885)1.74876588
150Abnormality of the astrocytes (HP:0100707)1.74861252
151Astrocytoma (HP:0009592)1.74861252
152Segmental peripheral demyelination/remyelination (HP:0003481)1.73805669
153Megaloblastic anemia (HP:0001889)1.73735719
154Hypertriglyceridemia (HP:0002155)1.72986953
155Fragile skin (HP:0001030)1.72642099
156Peripheral hypomyelination (HP:0007182)1.71969509
157Abnormality of the umbilical cord (HP:0010881)1.71048778
158Horseshoe kidney (HP:0000085)1.70688149
159Nausea (HP:0002018)1.70542841
160Paralysis (HP:0003470)1.69966428
161Mitral regurgitation (HP:0001653)1.69438548
162Agnosia (HP:0010524)1.69281183
163Slow saccadic eye movements (HP:0000514)1.69246667
164Personality changes (HP:0000751)1.69004760
165Atelectasis (HP:0100750)1.68890825
166Supranuclear gaze palsy (HP:0000605)1.68888811
167Shallow orbits (HP:0000586)1.68873794
168Hypoplastic left heart (HP:0004383)1.68565374
169Lower limb amyotrophy (HP:0007210)1.68542226
170Hyperparathyroidism (HP:0000843)1.68384564
171Thin ribs (HP:0000883)1.67718169
172Arnold-Chiari malformation (HP:0002308)1.67221893
173Foot dorsiflexor weakness (HP:0009027)1.66791710
174Pathologic fracture (HP:0002756)1.66624934
175Abnormal cartilage morphology (HP:0002763)1.66203105
176Meckel diverticulum (HP:0002245)1.66014938
177Right ventricular cardiomyopathy (HP:0011663)1.65572315
178Biconcave vertebral bodies (HP:0004586)1.65353764
179Breech presentation (HP:0001623)1.65258336
180Patellar dislocation (HP:0002999)1.64918190
181Spinal rigidity (HP:0003306)1.63719503
182Tongue fasciculations (HP:0001308)1.63121149
183Ureteral duplication (HP:0000073)1.62811874
184Abnormality of the ileum (HP:0001549)1.62051402
185Pointed chin (HP:0000307)1.61286835
186Decreased motor nerve conduction velocity (HP:0003431)1.61275584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.93446616
2BUB13.69158747
3WEE13.11670552
4PRPF4B2.90469010
5NME22.73434040
6NEK22.63467686
7NEK12.59834929
8EPHA22.55437619
9CDC72.54338189
10TRIB32.51080754
11PKN22.44087675
12IRAK32.36503848
13MAP3K102.31159667
14EIF2AK12.21937454
15TTK2.17782950
16CDK122.11672880
17EEF2K2.08869231
18RPS6KB22.03408058
19BCKDK1.92024291
20TTN1.89702252
21TLK11.79338247
22SIK11.78340615
23DYRK31.68507591
24RIPK11.67520810
25KSR21.66092521
26TESK21.65266084
27ARAF1.64239863
28MAP3K81.60048036
29PDK41.59496501
30PDK31.59496501
31CDK71.57904220
32MAP3K11.56418384
33CDK41.55911870
34PLK11.54616061
35MAP3K111.54032567
36MAPKAPK31.49669941
37PAK41.41464705
38MARK21.30055992
39AURKB1.30004834
40AURKA1.28517761
41MAP2K31.26725230
42STK101.25126650
43PRKD31.24980393
44LATS21.24632336
45FGFR41.24283117
46ICK1.22587826
47TESK11.22295934
48IRAK41.21341122
49SCYL21.19159401
50FLT31.15135909
51NME11.15067352
52SRPK11.13704833
53CHEK21.13152956
54BRSK21.08245084
55PIM21.07420315
56MAP2K21.07387816
57PASK1.04667766
58RPS6KA41.03927784
59LRRK20.98154417
60ACVR1B0.98062836
61PDPK10.96876982
62STK38L0.96114304
63IRAK20.95460697
64RIPK40.95414448
65PIM10.94656347
66PRKD20.93649864
67TYRO30.92267155
68CHEK10.91646709
69PLK40.91526801
70ILK0.89362527
71OBSCN0.88750325
72EPHB10.87747241
73KDR0.87659725
74MTOR0.87133747
75ATR0.86646253
76TSSK60.86445847
77CAMK1D0.85906104
78MAP3K90.82166980
79ERN10.81856642
80RPS6KC10.81631785
81RPS6KL10.81631785
82STK40.81327972
83RPS6KA20.81146637
84ALK0.80811289
85PDK20.78753303
86MAP3K30.78320557
87PAK10.77280558
88NTRK10.75163452
89MAP3K130.74254062
90AKT20.73758436
91CDK60.72885535
92MOS0.71771445
93CSK0.71600386
94PTK20.70971551
95CDK190.70791166
96EIF2AK30.68367822
97CDK20.68320987
98BMX0.66843292
99TGFBR10.66355948
100BRAF0.65217044
101FES0.64544677
102FGR0.63094231
103TAOK20.62694750
104TAOK10.60923639
105PRKCI0.59565981
106TBK10.57528955
107BRSK10.56558166
108MAP3K60.56087866
109DAPK30.56072227
110PRKG20.55953961
111RPS6KA60.54787034
112ATM0.54132707
113HIPK20.53747622
114MAP3K50.53543097
115* CSNK2A20.53315694
116MAPK120.52538315
117MAP2K40.52015206
118CDC42BPA0.51647924
119PDK10.51630890
120MAPK110.51466657
121GRK60.49504952
122DMPK0.49272350
123TYK20.46504845
124ABL20.45984857
125PLK30.45729692
126RAF10.45121913
127* CSNK2A10.45054838
128STK30.43887952
129PTK60.42998215
130STK110.41937461
131VRK10.41770285
132PAK20.41501268
133MET0.40891916
134DYRK1B0.40846877
135STK160.40831502
136SGK30.39937789
137LATS10.39934526
138RPS6KA10.39869388
139MELK0.39834768
140SIK20.39707178
141MAP4K10.37939347
142STK380.37805981
143CDK11A0.36838348
144ZAP700.36835351
145KSR10.35983421
146NEK90.35021837
147VRK20.34483067
148CDK10.34320391
149CAMK1G0.33880931
150RET0.33739587
151RPS6KA50.33023490
152* CSNK1E0.32316220
153LIMK10.31250103
154TNK20.30979901
155PDGFRA0.30601714

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.90354176
2Ribosome_Homo sapiens_hsa030103.52909430
3Mismatch repair_Homo sapiens_hsa034303.20365025
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06872984
5One carbon pool by folate_Homo sapiens_hsa006702.86343895
6RNA transport_Homo sapiens_hsa030132.85399845
7Spliceosome_Homo sapiens_hsa030402.66278612
8RNA polymerase_Homo sapiens_hsa030202.55733796
9Proteasome_Homo sapiens_hsa030502.54455527
10Base excision repair_Homo sapiens_hsa034102.41916811
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40609694
12Nucleotide excision repair_Homo sapiens_hsa034202.10235359
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.07739903
14Non-small cell lung cancer_Homo sapiens_hsa052232.06427967
15Homologous recombination_Homo sapiens_hsa034402.02253439
16Cell cycle_Homo sapiens_hsa041102.02108079
17Pyrimidine metabolism_Homo sapiens_hsa002401.98595291
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91275650
19VEGF signaling pathway_Homo sapiens_hsa043701.91109736
20Biosynthesis of amino acids_Homo sapiens_hsa012301.85909434
21Sulfur relay system_Homo sapiens_hsa041221.81351352
22Other glycan degradation_Homo sapiens_hsa005111.76311857
23Pancreatic cancer_Homo sapiens_hsa052121.74477082
24Prion diseases_Homo sapiens_hsa050201.65956720
25Carbon metabolism_Homo sapiens_hsa012001.64651472
26Endometrial cancer_Homo sapiens_hsa052131.59342784
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54261834
28Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.50942707
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47790151
30p53 signaling pathway_Homo sapiens_hsa041151.46952847
31mRNA surveillance pathway_Homo sapiens_hsa030151.46048391
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45416862
33Pentose phosphate pathway_Homo sapiens_hsa000301.44526503
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38960961
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.37475171
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.36482922
37Selenocompound metabolism_Homo sapiens_hsa004501.36143101
38Renal cell carcinoma_Homo sapiens_hsa052111.33822252
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32861836
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32579197
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32503662
42B cell receptor signaling pathway_Homo sapiens_hsa046621.31705662
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29729760
44Fanconi anemia pathway_Homo sapiens_hsa034601.29706881
45Glioma_Homo sapiens_hsa052141.28497924
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27525299
47RNA degradation_Homo sapiens_hsa030181.24243588
48Folate biosynthesis_Homo sapiens_hsa007901.23715163
49ErbB signaling pathway_Homo sapiens_hsa040121.17342313
50Basal transcription factors_Homo sapiens_hsa030221.17136939
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12605643
52Osteoclast differentiation_Homo sapiens_hsa043801.11607842
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09466527
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09082644
55Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07880506
56Systemic lupus erythematosus_Homo sapiens_hsa053221.04865901
57Adipocytokine signaling pathway_Homo sapiens_hsa049201.04447243
58Fructose and mannose metabolism_Homo sapiens_hsa000511.02153096
59Vitamin B6 metabolism_Homo sapiens_hsa007501.00355458
60Endocytosis_Homo sapiens_hsa041441.00226572
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.99105047
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98874275
63Colorectal cancer_Homo sapiens_hsa052100.98851727
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96806856
65Malaria_Homo sapiens_hsa051440.94382142
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90700701
67Shigellosis_Homo sapiens_hsa051310.89708484
68Glutathione metabolism_Homo sapiens_hsa004800.89432159
69Bladder cancer_Homo sapiens_hsa052190.87720177
70GnRH signaling pathway_Homo sapiens_hsa049120.87185136
71* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85467582
72Purine metabolism_Homo sapiens_hsa002300.83099704
73Epstein-Barr virus infection_Homo sapiens_hsa051690.81343001
74Thyroid cancer_Homo sapiens_hsa052160.80949092
75Hepatitis B_Homo sapiens_hsa051610.80924552
76Galactose metabolism_Homo sapiens_hsa000520.80603262
77Vibrio cholerae infection_Homo sapiens_hsa051100.80518569
78Arginine and proline metabolism_Homo sapiens_hsa003300.79774251
79Pyruvate metabolism_Homo sapiens_hsa006200.79472648
80Non-homologous end-joining_Homo sapiens_hsa034500.78913071
81Proteoglycans in cancer_Homo sapiens_hsa052050.78828808
82Salmonella infection_Homo sapiens_hsa051320.78362516
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.78096803
84Inositol phosphate metabolism_Homo sapiens_hsa005620.77900344
85Huntingtons disease_Homo sapiens_hsa050160.77393512
86Viral carcinogenesis_Homo sapiens_hsa052030.76524383
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.75933825
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.75548109
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75076744
90Synaptic vesicle cycle_Homo sapiens_hsa047210.73137593
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.73072323
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73065592
93Choline metabolism in cancer_Homo sapiens_hsa052310.71241722
94Hepatitis C_Homo sapiens_hsa051600.70388459
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.69679215
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69379166
97Arginine biosynthesis_Homo sapiens_hsa002200.68933660
98Parkinsons disease_Homo sapiens_hsa050120.68071206
99Amoebiasis_Homo sapiens_hsa051460.67945489
100Fat digestion and absorption_Homo sapiens_hsa049750.67191434
101Prolactin signaling pathway_Homo sapiens_hsa049170.64959740
102Focal adhesion_Homo sapiens_hsa045100.62880301
103FoxO signaling pathway_Homo sapiens_hsa040680.62727735
104Prostate cancer_Homo sapiens_hsa052150.62108900
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61166996
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60379693
107Long-term potentiation_Homo sapiens_hsa047200.59836238
108MAPK signaling pathway_Homo sapiens_hsa040100.59018072
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58470175
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58147897
111Propanoate metabolism_Homo sapiens_hsa006400.57869477
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57680586
113Hippo signaling pathway_Homo sapiens_hsa043900.57610327
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56884701
115Fatty acid degradation_Homo sapiens_hsa000710.56734100
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55867579
117HTLV-I infection_Homo sapiens_hsa051660.55707858
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55588091
119Oocyte meiosis_Homo sapiens_hsa041140.55094804
120Small cell lung cancer_Homo sapiens_hsa052220.55063703
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54300183
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52910590
123Insulin resistance_Homo sapiens_hsa049310.52441774
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52171950
125Tuberculosis_Homo sapiens_hsa051520.51782548
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.51651630
127Lysosome_Homo sapiens_hsa041420.51602974
128Basal cell carcinoma_Homo sapiens_hsa052170.51574843
129Rap1 signaling pathway_Homo sapiens_hsa040150.51142972
130Leishmaniasis_Homo sapiens_hsa051400.48443683
131Chemokine signaling pathway_Homo sapiens_hsa040620.48380984
132HIF-1 signaling pathway_Homo sapiens_hsa040660.47323037
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47070770
134MicroRNAs in cancer_Homo sapiens_hsa052060.46144582
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45751006
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44768572
137TNF signaling pathway_Homo sapiens_hsa046680.44744603
138Estrogen signaling pathway_Homo sapiens_hsa049150.43922203
139Tight junction_Homo sapiens_hsa045300.42753938
140* Herpes simplex infection_Homo sapiens_hsa051680.42187264
141mTOR signaling pathway_Homo sapiens_hsa041500.42071636
142Legionellosis_Homo sapiens_hsa051340.41166696
143Apoptosis_Homo sapiens_hsa042100.40139599
144Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39793923
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37304110
146Oxidative phosphorylation_Homo sapiens_hsa001900.37278128
147Lysine degradation_Homo sapiens_hsa003100.37221301
148Cardiac muscle contraction_Homo sapiens_hsa042600.36033597
149Metabolic pathways_Homo sapiens_hsa011000.35095433
150Acute myeloid leukemia_Homo sapiens_hsa052210.34942649
151Notch signaling pathway_Homo sapiens_hsa043300.34140823
152AMPK signaling pathway_Homo sapiens_hsa041520.33803791
153TGF-beta signaling pathway_Homo sapiens_hsa043500.33650211
154Viral myocarditis_Homo sapiens_hsa054160.33494521
155Antigen processing and presentation_Homo sapiens_hsa046120.32988948
156Hedgehog signaling pathway_Homo sapiens_hsa043400.31493365
157Linoleic acid metabolism_Homo sapiens_hsa005910.31456440
158Chronic myeloid leukemia_Homo sapiens_hsa052200.30116120
159Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27347699
160Adherens junction_Homo sapiens_hsa045200.26522516
161Phenylalanine metabolism_Homo sapiens_hsa003600.26258321
162beta-Alanine metabolism_Homo sapiens_hsa004100.24446210
163Insulin signaling pathway_Homo sapiens_hsa049100.22688902

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