CDC27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.04438439
2mitotic sister chromatid cohesion (GO:0007064)5.93748850
3nuclear pore organization (GO:0006999)5.72695489
4protein localization to kinetochore (GO:0034501)5.45168448
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.02736080
6mitotic chromosome condensation (GO:0007076)4.87956630
7protein localization to chromosome, centromeric region (GO:0071459)4.77203544
8mitotic metaphase plate congression (GO:0007080)4.75220789
9sister chromatid segregation (GO:0000819)4.74773497
10regulation of spindle organization (GO:0090224)4.54592462
11positive regulation of mitotic sister chromatid separation (GO:1901970)4.52771996
12positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.52771996
13positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.52771996
14sphingosine metabolic process (GO:0006670)4.44268280
15mitotic nuclear envelope disassembly (GO:0007077)4.39106204
16regulation of sister chromatid cohesion (GO:0007063)4.37488842
17pore complex assembly (GO:0046931)4.35653174
18mitotic sister chromatid segregation (GO:0000070)4.34733136
19metaphase plate congression (GO:0051310)4.34100083
20kinetochore organization (GO:0051383)4.26168621
21membrane disassembly (GO:0030397)4.24545644
22nuclear envelope disassembly (GO:0051081)4.24545644
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.20613098
24positive regulation of chromosome segregation (GO:0051984)4.18222540
25DNA unwinding involved in DNA replication (GO:0006268)4.17852016
26regulation of mitotic spindle organization (GO:0060236)4.16204807
27pre-miRNA processing (GO:0031054)4.12807138
28regulation of RNA export from nucleus (GO:0046831)4.10572055
29attachment of spindle microtubules to kinetochore (GO:0008608)4.10288676
30establishment of chromosome localization (GO:0051303)4.04933239
31monoubiquitinated protein deubiquitination (GO:0035520)4.02658284
32protein localization to chromosome (GO:0034502)3.72626134
33regulation of centriole replication (GO:0046599)3.70912363
34protoporphyrinogen IX metabolic process (GO:0046501)3.70367826
35diol metabolic process (GO:0034311)3.68864561
36* spindle checkpoint (GO:0031577)3.63173519
37* regulation of chromosome segregation (GO:0051983)3.61864120
38sphingoid metabolic process (GO:0046519)3.61798575
39histone H2A monoubiquitination (GO:0035518)3.60153116
40DNA replication-dependent nucleosome assembly (GO:0006335)3.59646568
41DNA replication-dependent nucleosome organization (GO:0034723)3.59646568
42negative regulation of DNA repair (GO:0045738)3.55549750
43double-strand break repair via nonhomologous end joining (GO:0006303)3.55201605
44non-recombinational repair (GO:0000726)3.55201605
45* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55142753
46regulation of centrosome cycle (GO:0046605)3.49406072
47* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48816821
48regulation of DNA endoreduplication (GO:0032875)3.47298049
49negative regulation of histone methylation (GO:0031061)3.43149600
50negative regulation of cell cycle G2/M phase transition (GO:1902750)3.42460220
51DNA replication-independent nucleosome organization (GO:0034724)3.41984482
52DNA replication-independent nucleosome assembly (GO:0006336)3.41984482
53histone-serine phosphorylation (GO:0035404)3.41716231
54CENP-A containing nucleosome assembly (GO:0034080)3.41257941
55chromatin remodeling at centromere (GO:0031055)3.37395291
56meiotic chromosome segregation (GO:0045132)3.36608599
57DNA ligation (GO:0006266)3.35916329
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35724428
59chromosome segregation (GO:0007059)3.35184123
60kinetochore assembly (GO:0051382)3.34062113
61* spindle assembly checkpoint (GO:0071173)3.33099510
62regulation of histone H3-K9 methylation (GO:0051570)3.32387878
63* regulation of sister chromatid segregation (GO:0033045)3.31348982
64* regulation of mitotic sister chromatid separation (GO:0010965)3.31348982
65* regulation of mitotic sister chromatid segregation (GO:0033047)3.31348982
66chromosome condensation (GO:0030261)3.31274698
67histone exchange (GO:0043486)3.29803956
68* mitotic spindle checkpoint (GO:0071174)3.29612768
69nuclear envelope organization (GO:0006998)3.27798917
70chromatin assembly or disassembly (GO:0006333)3.26023560
71NLS-bearing protein import into nucleus (GO:0006607)3.22947079
72* mitotic spindle assembly checkpoint (GO:0007094)3.20787739
73DNA strand elongation involved in DNA replication (GO:0006271)3.20522351
74* negative regulation of chromosome segregation (GO:0051985)3.20254336
75* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18737552
76* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18737552
77* negative regulation of sister chromatid segregation (GO:0033046)3.18737552
78* negative regulation of mitotic sister chromatid separation (GO:2000816)3.18737552
79mitotic recombination (GO:0006312)3.18156028
80regulation of nucleobase-containing compound transport (GO:0032239)3.17778423
81regulation of pigment cell differentiation (GO:0050932)3.16892244
82positive regulation of developmental pigmentation (GO:0048087)3.14915767
83cytoskeleton-dependent cytokinesis (GO:0061640)3.13516323
84regulation of transforming growth factor beta2 production (GO:0032909)3.13375638
85sister chromatid cohesion (GO:0007062)3.13142301
86DNA strand elongation (GO:0022616)3.13031241
87* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11597859
88DNA duplex unwinding (GO:0032508)3.09810064
89DNA geometric change (GO:0032392)3.08600923
90mitotic spindle organization (GO:0007052)3.08324078
91ATP-dependent chromatin remodeling (GO:0043044)3.07891771
92telomere maintenance via semi-conservative replication (GO:0032201)3.07850976
93SMAD protein complex assembly (GO:0007183)3.06821689
94protoporphyrinogen IX biosynthetic process (GO:0006782)3.06521673
95chromatin assembly (GO:0031497)3.05408193
96regulation of centrosome duplication (GO:0010824)3.04613441
97establishment of integrated proviral latency (GO:0075713)3.04462865
98dosage compensation (GO:0007549)3.04167058
99notochord development (GO:0030903)3.03976657
100regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.03923871
101paraxial mesoderm development (GO:0048339)3.02819879
102Golgi transport vesicle coating (GO:0048200)3.01179867
103COPI coating of Golgi vesicle (GO:0048205)3.01179867
104DNA packaging (GO:0006323)3.01076796
105spindle assembly involved in mitosis (GO:0090307)2.98419328
106ribonucleoprotein complex disassembly (GO:0032988)2.98200605
107spindle organization (GO:0007051)2.97513508
108centrosome duplication (GO:0051298)2.96663008
109glucocorticoid receptor signaling pathway (GO:0042921)2.95489934
110gene silencing by RNA (GO:0031047)2.90260697
111DNA replication initiation (GO:0006270)2.89930758
112DNA synthesis involved in DNA repair (GO:0000731)2.89727614
113heterochromatin organization (GO:0070828)2.88298962
114DNA topological change (GO:0006265)2.87983921
115ribosome assembly (GO:0042255)2.87394710
116DNA replication checkpoint (GO:0000076)2.86898950
117hippo signaling (GO:0035329)2.85156429
118IMP biosynthetic process (GO:0006188)2.84603918
119DNA conformation change (GO:0071103)2.81326118
120IMP metabolic process (GO:0046040)2.80585211
121mRNA stabilization (GO:0048255)2.80252838
122RNA stabilization (GO:0043489)2.80252838
123mitotic cytokinesis (GO:0000281)2.78420248
124microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.77593626
125regulation of translational termination (GO:0006449)2.74408119
126microtubule depolymerization (GO:0007019)2.72362024
127protein K6-linked ubiquitination (GO:0085020)2.71814958
128translesion synthesis (GO:0019985)2.71375589
129negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.70520249
130cytoplasmic mRNA processing body assembly (GO:0033962)2.69878875
131nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.67325429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.10186434
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.73771325
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.05937339
4RBPJ_22232070_ChIP-Seq_NCS_Mouse4.02887445
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.90268300
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.88906768
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.60095238
8AR_21909140_ChIP-Seq_LNCAP_Human3.32979927
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20730202
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.99715040
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.65353599
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.63151996
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52123058
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41067943
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.07790155
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03110718
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.01709778
18E2F7_22180533_ChIP-Seq_HELA_Human10.4950546
19GATA1_22025678_ChIP-Seq_K562_Human1.92576254
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85302935
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82174558
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80031372
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73803589
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71583756
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61058667
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60604477
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60504432
28* ELK1_19687146_ChIP-ChIP_HELA_Human1.60020442
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53797401
30MYC_22102868_ChIP-Seq_BL_Human1.53685442
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50080549
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48310808
33CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47436887
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46154039
35SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.42965975
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41803370
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37668085
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37591376
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34764223
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34403709
41* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30862509
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30490374
43* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.29981229
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29844872
45* BRD4_25478319_ChIP-Seq_HGPS_Human1.27820851
46* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27055092
47SOX17_20123909_ChIP-Seq_XEN_Mouse1.24673026
48* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23275947
49XRN2_22483619_ChIP-Seq_HELA_Human1.23085173
50* NANOG_21062744_ChIP-ChIP_HESCs_Human1.20767540
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.20142743
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19234692
53CIITA_25753668_ChIP-Seq_RAJI_Human1.19229205
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16729155
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16666806
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15516937
57FUS_26573619_Chip-Seq_HEK293_Human1.15501525
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14187886
59CHD1_26751641_Chip-Seq_LNCaP_Human1.12723025
60AR_21572438_ChIP-Seq_LNCaP_Human1.11128744
61KDM5A_27292631_Chip-Seq_BREAST_Human1.10875775
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10833853
63* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09724066
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08291722
65EWS_26573619_Chip-Seq_HEK293_Human1.07595512
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07558488
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07074375
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06291224
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06245119
70TTF2_22483619_ChIP-Seq_HELA_Human1.05021673
71* VDR_23849224_ChIP-Seq_CD4+_Human1.04717100
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03880019
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03201865
74SOX9_26525672_Chip-Seq_HEART_Mouse1.02088790
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01291538
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99122191
77THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97460403
78* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97264873
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96979202
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96568283
81SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95070673
82WT1_19549856_ChIP-ChIP_CCG9911_Human0.94762690
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94681846
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93763927
85EST1_17652178_ChIP-ChIP_JURKAT_Human0.93447595
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90156039
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89343434
88CLOCK_20551151_ChIP-Seq_293T_Human0.89038019
89FOXP3_21729870_ChIP-Seq_TREG_Human0.88986071
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88788358
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86845603
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86359507
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85809627
94TP53_18474530_ChIP-ChIP_U2OS_Human0.84977657
95CJUN_26792858_Chip-Seq_BT549_Human0.84464663
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84160856
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82638049
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82324504
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81716696
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81205582
101TFEB_21752829_ChIP-Seq_HELA_Human0.80812875
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80488520
103NANOG_16153702_ChIP-ChIP_HESCs_Human0.80178430
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79998208
105EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79614148
106* STAT3_23295773_ChIP-Seq_U87_Human0.78220187
107TAF15_26573619_Chip-Seq_HEK293_Human0.77409785
108* GABP_19822575_ChIP-Seq_HepG2_Human0.76876365
109NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.76864673
110GATA4_21415370_ChIP-Seq_HL-1_Mouse0.76654605
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.76541659
112POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.76348433
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.76039989
114* IGF1R_20145208_ChIP-Seq_DFB_Human0.75656839
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.75076013
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74945389
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.74834302
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74590156
119TBX3_20139965_ChIP-Seq_ESCs_Mouse0.73800508
120TP53_16413492_ChIP-PET_HCT116_Human0.73680085
121TBX3_20139965_ChIP-Seq_MESCs_Mouse0.72676489
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71594271
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71594271
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71461674
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71347899
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71347899
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.70407892
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.69793146
129* DCP1A_22483619_ChIP-Seq_HELA_Human0.68294630
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.67603838
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67201419
132KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.66639502
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.66432745
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.66366541
135ZFP281_27345836_Chip-Seq_ESCs_Mouse0.66242981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.41702355
2MP0003111_abnormal_nucleus_morphology3.10112163
3MP0003693_abnormal_embryo_hatching2.97289487
4MP0010352_gastrointestinal_tract_polyps2.95707046
5MP0005171_absent_coat_pigmentation2.89768290
6MP0003077_abnormal_cell_cycle2.89411133
7MP0003123_paternal_imprinting2.77802975
8MP0003705_abnormal_hypodermis_morpholog2.77388807
9MP0004957_abnormal_blastocyst_morpholog2.74980540
10MP0003950_abnormal_plasma_membrane2.68960346
11MP0009697_abnormal_copulation2.65351895
12MP0003121_genomic_imprinting2.49450885
13MP0008057_abnormal_DNA_replication2.43270186
14MP0010307_abnormal_tumor_latency2.40668602
15MP0004147_increased_porphyrin_level2.36828002
16MP0001730_embryonic_growth_arrest2.25298329
17MP0000569_abnormal_digit_pigmentation2.22788749
18MP0008007_abnormal_cellular_replicative2.13852251
19MP0003656_abnormal_erythrocyte_physiolo2.10123128
20MP0009053_abnormal_anal_canal2.01559014
21MP0000350_abnormal_cell_proliferation1.98625100
22MP0005076_abnormal_cell_differentiation1.97903105
23MP0002837_dystrophic_cardiac_calcinosis1.93701708
24MP0001672_abnormal_embryogenesis/_devel1.93402039
25MP0005380_embryogenesis_phenotype1.93402039
26MP0002084_abnormal_developmental_patter1.87844232
27MP0001697_abnormal_embryo_size1.85110315
28MP0003984_embryonic_growth_retardation1.84309416
29MP0002088_abnormal_embryonic_growth/wei1.83327076
30MP0008932_abnormal_embryonic_tissue1.83303428
31MP0008877_abnormal_DNA_methylation1.81996301
32MP0008438_abnormal_cutaneous_collagen1.79578128
33MP0003937_abnormal_limbs/digits/tail_de1.79543981
34MP0004197_abnormal_fetal_growth/weight/1.76427085
35MP0003890_abnormal_embryonic-extraembry1.75425296
36MP0003567_abnormal_fetal_cardiomyocyte1.75008684
37MP0010234_abnormal_vibrissa_follicle1.73246669
38MP0002086_abnormal_extraembryonic_tissu1.72054247
39MP0002085_abnormal_embryonic_tissue1.70135061
40MP0000537_abnormal_urethra_morphology1.70063810
41MP0004808_abnormal_hematopoietic_stem1.65738459
42MP0000733_abnormal_muscle_development1.59954828
43MP0003941_abnormal_skin_development1.58794886
44MP0008058_abnormal_DNA_repair1.58689621
45MP0005623_abnormal_meninges_morphology1.57386273
46MP0006054_spinal_hemorrhage1.51519502
47MP0001661_extended_life_span1.49049971
48MP0010030_abnormal_orbit_morphology1.46382047
49MP0003122_maternal_imprinting1.46317164
50MP0002396_abnormal_hematopoietic_system1.43733582
51MP0001293_anophthalmia1.43656888
52MP0005248_abnormal_Harderian_gland1.43331947
53MP0000749_muscle_degeneration1.43301010
54MP0002080_prenatal_lethality1.40003158
55MP0003045_fibrosis1.39833396
56MP0002877_abnormal_melanocyte_morpholog1.38953222
57MP0002009_preneoplasia1.38707733
58MP0005083_abnormal_biliary_tract1.37453152
59MP0009703_decreased_birth_body1.35779767
60MP0003136_yellow_coat_color1.33110276
61MP0000428_abnormal_craniofacial_morphol1.32904081
62MP0009672_abnormal_birth_weight1.32472876
63MP0003935_abnormal_craniofacial_develop1.31819271
64MP0003115_abnormal_respiratory_system1.29366539
65MP0005503_abnormal_tendon_morphology1.27041035
66MP0005187_abnormal_penis_morphology1.20289818
67MP0001915_intracranial_hemorrhage1.18581170
68MP0003787_abnormal_imprinting1.18162751
69MP0003385_abnormal_body_wall1.16578359
70MP0002269_muscular_atrophy1.16534322
71MP0000432_abnormal_head_morphology1.12353596
72MP0002925_abnormal_cardiovascular_devel1.11320871
73MP0003566_abnormal_cell_adhesion1.10907583
74MP0000516_abnormal_urinary_system1.08770622
75MP0005367_renal/urinary_system_phenotyp1.08770622
76MP0001849_ear_inflammation1.07764885
77MP0003755_abnormal_palate_morphology1.07400672
78MP0004233_abnormal_muscle_weight1.06920453
79MP0002282_abnormal_trachea_morphology1.06683439
80MP0002060_abnormal_skin_morphology1.04946739
81MP0005395_other_phenotype1.03450381
82MP0010368_abnormal_lymphatic_system1.00737910
83MP0003119_abnormal_digestive_system1.00411377
84MP0009250_abnormal_appendicular_skeleto0.99744325
85MP0005621_abnormal_cell_physiology0.99537174
86MP0004084_abnormal_cardiac_muscle0.99449288
87MP0003942_abnormal_urinary_system0.97038559
88MP0002092_abnormal_eye_morphology0.96766370
89MP0005275_abnormal_skin_tensile0.96371886
90MP0004185_abnormal_adipocyte_glucose0.96022087
91MP0003718_maternal_effect0.95693725
92MP0003091_abnormal_cell_migration0.95458144
93MP0003221_abnormal_cardiomyocyte_apopto0.94590359
94MP0005257_abnormal_intraocular_pressure0.93832770
95MP0002932_abnormal_joint_morphology0.93354768
96MP0005023_abnormal_wound_healing0.93288464
97MP0002210_abnormal_sex_determination0.93212343
98MP0002697_abnormal_eye_size0.92349721
99MP0001299_abnormal_eye_distance/0.88082145
100MP0002166_altered_tumor_susceptibility0.88053079
101MP0001286_abnormal_eye_development0.86746810
102MP0000358_abnormal_cell_content/0.85402190
103MP0000266_abnormal_heart_morphology0.85362047
104MP0009384_cardiac_valve_regurgitation0.85011781
105MP0000313_abnormal_cell_death0.84233019
106MP0002168_other_aberrant_phenotype0.83649094
107MP0003943_abnormal_hepatobiliary_system0.83153706
108MP0005384_cellular_phenotype0.81000228
109MP0004272_abnormal_basement_membrane0.80481731
110MP0002109_abnormal_limb_morphology0.80480924
111MP0002938_white_spotting0.80187665
112MP0002111_abnormal_tail_morphology0.80027928
113MP0002006_tumorigenesis0.79968718
114MP0000427_abnormal_hair_cycle0.79725113
115MP0010678_abnormal_skin_adnexa0.79455491
116MP0003861_abnormal_nervous_system0.79328486
117MP0001929_abnormal_gametogenesis0.79181313
118MP0010630_abnormal_cardiac_muscle0.78952833
119MP0005397_hematopoietic_system_phenotyp0.77932285
120MP0001545_abnormal_hematopoietic_system0.77932285
121MP0003868_abnormal_feces_composition0.77459746
122MP0001145_abnormal_male_reproductive0.77181438
123MP0000653_abnormal_sex_gland0.77108179
124MP0000534_abnormal_ureter_morphology0.77082743
125MP0002019_abnormal_tumor_incidence0.75775289
126MP0005451_abnormal_body_composition0.75769349
127MP0008770_decreased_survivor_rate0.68245865
128MP0002075_abnormal_coat/hair_pigmentati0.67072870
129MP0006138_congestive_heart_failure0.64882140
130MP0001879_abnormal_lymphatic_vessel0.64749339
131MP0001186_pigmentation_phenotype0.64040818
132MP0003646_muscle_fatigue0.64014176
133MP0002095_abnormal_skin_pigmentation0.63991392
134MP0000759_abnormal_skeletal_muscle0.63281172
135MP0002177_abnormal_outer_ear0.61732880
136MP0002160_abnormal_reproductive_system0.60418669
137MP0005408_hypopigmentation0.58668695

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.01272356
2Acanthocytosis (HP:0001927)4.42581082
3Short 4th metacarpal (HP:0010044)4.34156985
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.34156985
5Volvulus (HP:0002580)3.76160582
6Poikilocytosis (HP:0004447)3.71829912
7Abnormality of the 4th metacarpal (HP:0010012)3.17812802
8Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.17080232
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.12687183
10Shallow orbits (HP:0000586)3.01285218
11Papillary thyroid carcinoma (HP:0002895)2.96721732
12Overlapping toe (HP:0001845)2.87676515
13Vertebral arch anomaly (HP:0008438)2.86788119
14Facial hemangioma (HP:0000329)2.80494415
15Abnormality of the labia minora (HP:0012880)2.76048189
16Increased nuchal translucency (HP:0010880)2.73285499
17Colon cancer (HP:0003003)2.67104799
18Subacute progressive viral hepatitis (HP:0006572)2.63667718
19Deviation of the thumb (HP:0009603)2.54808962
20Termporal pattern (HP:0011008)2.52857902
21Insidious onset (HP:0003587)2.52857902
22Enlarged penis (HP:0000040)2.51406014
23Medulloblastoma (HP:0002885)2.47726476
24Selective tooth agenesis (HP:0001592)2.43766985
25Impulsivity (HP:0100710)2.41689625
26Ankle contracture (HP:0006466)2.41267564
27Long eyelashes (HP:0000527)2.40322160
28Birth length less than 3rd percentile (HP:0003561)2.38606209
29Protrusio acetabuli (HP:0003179)2.35125774
30Proximal placement of thumb (HP:0009623)2.34503508
31Increased mean platelet volume (HP:0011877)2.33718545
32Meckel diverticulum (HP:0002245)2.32939499
33Abnormal auditory evoked potentials (HP:0006958)2.32919336
34Neoplasm of the small intestine (HP:0100833)2.31830650
35Osteolytic defects of the hand bones (HP:0009699)2.29099117
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.29099117
37Duodenal stenosis (HP:0100867)2.28606856
38Small intestinal stenosis (HP:0012848)2.28606856
39Microglossia (HP:0000171)2.27519897
40Cortical dysplasia (HP:0002539)2.27341484
41Ankyloglossia (HP:0010296)2.26316912
42Orthostatic hypotension (HP:0001278)2.24232570
43Abnormality of the ileum (HP:0001549)2.22289754
44Neoplasm of the colon (HP:0100273)2.19902929
45Deep philtrum (HP:0002002)2.19764652
46Atresia of the external auditory canal (HP:0000413)2.18347922
47Broad thumb (HP:0011304)2.17458042
48Myelodysplasia (HP:0002863)2.13823615
49Asymmetry of the thorax (HP:0001555)2.13161262
50Syringomyelia (HP:0003396)2.12195966
51Spinal cord lesions (HP:0100561)2.12195966
52Insomnia (HP:0100785)2.10402351
53Trigonocephaly (HP:0000243)2.09204504
54Missing ribs (HP:0000921)2.07273808
55Heterotopia (HP:0002282)2.06913848
56Abnormality of the preputium (HP:0100587)2.06006340
57Ulnar bowing (HP:0003031)2.05506563
58Chromsome breakage (HP:0040012)2.03913074
59Narrow palate (HP:0000189)2.03480796
60Wrist flexion contracture (HP:0001239)2.03374613
61Arterial tortuosity (HP:0005116)2.03136295
62Truncal obesity (HP:0001956)2.02738355
63Rhabdomyosarcoma (HP:0002859)2.02498850
64Capillary hemangiomas (HP:0005306)2.02476499
65Soft skin (HP:0000977)2.02187977
66Ectopic kidney (HP:0000086)2.00163749
67Abnormality of chromosome stability (HP:0003220)1.99740475
68Increased density of long bones (HP:0006392)1.99203795
69Abnormality of the astrocytes (HP:0100707)1.99120497
70Astrocytoma (HP:0009592)1.99120497
71Abnormality of the intrinsic pathway (HP:0010989)1.97700202
72High pitched voice (HP:0001620)1.97283981
73Broad phalanges of the hand (HP:0009768)1.97253534
74Uterine leiomyosarcoma (HP:0002891)1.96986802
75Leiomyosarcoma (HP:0100243)1.96986802
76Acute myeloid leukemia (HP:0004808)1.96243301
77Broad palm (HP:0001169)1.95612040
78Neoplasm of the oral cavity (HP:0100649)1.95372338
79Dysmetric saccades (HP:0000641)1.94655385
80Prominent nose (HP:0000448)1.94127426
81Gastrointestinal carcinoma (HP:0002672)1.94068840
82Malignant gastrointestinal tract tumors (HP:0006749)1.94068840
83Patellar aplasia (HP:0006443)1.93882095
84Renal duplication (HP:0000075)1.93001696
85Vascular tortuosity (HP:0004948)1.91918978
86Aortic aneurysm (HP:0004942)1.91256446
87Abnormality of the carotid arteries (HP:0005344)1.91191927
88Hepatoblastoma (HP:0002884)1.91190490
89Macroorchidism (HP:0000053)1.89459070
90Sandal gap (HP:0001852)1.89431672
91Abnormal lung lobation (HP:0002101)1.89324804
92Abnormality of the fingertips (HP:0001211)1.88478464
93Neoplasm of the adrenal cortex (HP:0100641)1.87998541
94Broad finger (HP:0001500)1.87885226
95Absent frontal sinuses (HP:0002688)1.87781887
96Arteriovenous malformation (HP:0100026)1.87562263
97Broad phalanx (HP:0006009)1.86525098
98Aplasia/Hypoplasia of the patella (HP:0006498)1.86355571
99Abnormal foot bone ossification (HP:0010675)1.85830436
100Degeneration of anterior horn cells (HP:0002398)1.85787866
101Abnormality of the anterior horn cell (HP:0006802)1.85787866
102Broad long bones (HP:0005622)1.85243881
103Neonatal death (HP:0003811)1.84305363
104Cerebral aneurysm (HP:0004944)1.84046271
105Abnormality of oral frenula (HP:0000190)1.83488599
106Thyroid carcinoma (HP:0002890)1.81698398
107Scapular winging (HP:0003691)1.81480604
108Bowel diverticulosis (HP:0005222)1.81442636
109Biliary tract neoplasm (HP:0100574)1.81129901
110Glioma (HP:0009733)1.81086002
111Mitral valve prolapse (HP:0001634)1.80120496
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.79633099
113Premature rupture of membranes (HP:0001788)1.79079449
114Ependymoma (HP:0002888)1.79001558
115Abnormal platelet volume (HP:0011876)1.78922516
116Proximal amyotrophy (HP:0007126)1.78797231
117Nephroblastoma (Wilms tumor) (HP:0002667)1.78001380
118Relative macrocephaly (HP:0004482)1.77572616
119Transitional cell carcinoma of the bladder (HP:0006740)1.76874236
120Urethral obstruction (HP:0000796)1.75906561
121Dilatation of the ascending aorta (HP:0005111)1.75673874
122Deviation of the hallux (HP:0010051)1.74948615
123Neoplasm of striated muscle (HP:0009728)1.74147764
124Oligodactyly (HP:0012165)1.74067784
125Hallux valgus (HP:0001822)1.73980310
126Abnormality of the distal phalanx of the thumb (HP:0009617)1.73801428
127Abnormality of chromosome segregation (HP:0002916)1.73628520
128Hypopigmentation of the fundus (HP:0007894)1.72560345
129Cutis marmorata (HP:0000965)1.72028434
130Pelvic girdle muscle weakness (HP:0003749)1.71763537
131Genu recurvatum (HP:0002816)1.71712954
132Cutaneous melanoma (HP:0012056)1.70689949
133Hypoplastic labia majora (HP:0000059)1.70553491
134Skull defect (HP:0001362)1.70118462
135Entropion (HP:0000621)1.69878030
136Embryonal renal neoplasm (HP:0011794)1.69340024
137Skin tags (HP:0010609)1.69120032
138Broad ribs (HP:0000885)1.68686905
139Rectal prolapse (HP:0002035)1.68171666
140Midline defect of the nose (HP:0004122)1.68043137
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67612974
142Aortic dissection (HP:0002647)1.67190946
143Delayed closure of the anterior fontanelle (HP:0001476)1.66768102
144Wormian bones (HP:0002645)1.66264734
145Low anterior hairline (HP:0000294)1.65981428
146Cafe-au-lait spot (HP:0000957)1.64916424
147Obsessive-compulsive behavior (HP:0000722)1.64808145
148Embryonal neoplasm (HP:0002898)1.64785462
149Abnormality of the left ventricular outflow tract (HP:0011103)1.64296422
150Subaortic stenosis (HP:0001682)1.64296422
151Bladder carcinoma (HP:0002862)1.64290567
152Bladder neoplasm (HP:0009725)1.64290567
153Supernumerary ribs (HP:0005815)1.63526579
154Abnormality of the duodenum (HP:0002246)1.63217502
155Fair hair (HP:0002286)1.62364033
156Abnormality of the acetabulum (HP:0003170)1.61737528
157Poikiloderma (HP:0001029)1.61586271
158Long clavicles (HP:0000890)1.61464497
159Abnormality of the heme biosynthetic pathway (HP:0010472)1.61341708
160Convex nasal ridge (HP:0000444)1.61254132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.43368710
2LATS13.29702562
3NEK23.06220240
4CDK122.93863184
5WEE12.70022231
6BRSK22.54278392
7PBK2.32887903
8NEK12.27608428
9MKNK12.21703567
10TTK2.18811552
11PLK32.13958830
12SCYL22.12821955
13PLK41.99721003
14SRPK11.96751284
15STK31.87511154
16EIF2AK31.78426998
17CDK61.77992493
18LATS21.76101233
19CHEK21.74238270
20FRK1.73737231
21PKN21.73533695
22MST1R1.64974896
23* PLK11.64481726
24EEF2K1.63370660
25CAMK1D1.59348332
26ACVR1B1.58819376
27AURKB1.55251382
28RPS6KA41.50237881
29STK101.49528576
30BUB11.45468827
31ATR1.44534087
32MET1.38206083
33MKNK21.35635926
34EIF2AK11.35524746
35CHEK11.32750602
36MAP3K101.32311922
37MAP3K81.30480698
38PDGFRA1.30465346
39BRSK11.25443166
40CDK41.23347922
41ATM1.22142134
42PASK1.16324577
43MELK1.13200238
44STK381.12513036
45TAF11.12445912
46PRKD31.12251285
47CDK71.11969265
48ALK1.09840151
49NEK91.08108316
50CAMK1G1.07365503
51MTOR1.04660585
52TTN1.03855748
53FGFR11.02605868
54ERBB30.99632850
55CLK10.98954813
56BRD40.98544433
57FGFR20.97347120
58RPS6KB20.95515452
59TGFBR10.93409269
60CCNB10.92459205
61FGFR30.92198529
62TRIM280.90751740
63* CDK20.90217310
64TSSK60.88563741
65ZAK0.87302477
66STK40.84839764
67ICK0.84019162
68DDR20.83000510
69TRIB30.82581638
70BCR0.82109773
71MST40.80852467
72PNCK0.80425236
73* CDK10.78752479
74DYRK30.76822905
75PDK40.76230020
76PDK30.76230020
77KSR10.74912972
78CDK90.72579792
79PAK20.72480028
80IRAK30.71287285
81LRRK20.68497208
82PLK20.68272256
83KSR20.66266477
84PAK40.62397770
85BRAF0.60342214
86TESK10.58188000
87AURKA0.57414267
88STK38L0.56901988
89MARK30.56805548
90CSNK1D0.55858657
91VRK10.55147582
92RPS6KB10.55058313
93BMPR1B0.53463668
94PDGFRB0.52966282
95CSNK1A1L0.52945127
96DMPK0.52341380
97NUAK10.52129598
98NLK0.51618401
99AKT20.50848145
100AKT30.50679048
101PTK60.49609466
102PRKDC0.48964387
103MAP3K20.48302597
104BMPR20.48202742
105PIM10.47125210
106TRPM70.47063550
107PIK3CG0.46051748
108AKT10.45930595
109* MAPK140.45069360
110EIF2AK20.44713286
111CSNK1E0.42858141
112RAF10.42064394
113SIK10.41882885
114MAPK100.41220191
115PDK20.40974454
116PTK20.38992347
117STK390.38919116
118WNK10.38640484
119CDK80.36983573
120BMX0.35973833
121SGK30.35928641
122FLT30.35344119
123TGFBR20.34671061
124MAPK10.33882625
125CHUK0.33758281
126FER0.33619052
127RET0.32862765
128ERBB40.31705226
129MAP2K10.31441181
130MOS0.30690540
131CDK180.29770824
132CDK150.26206072
133CDK11A0.18415009
134CDK140.18231520

Predicted pathways (KEGG)

RankGene SetZ-score
1* Cell cycle_Homo sapiens_hsa041103.50591450
2RNA transport_Homo sapiens_hsa030132.97253001
3DNA replication_Homo sapiens_hsa030302.87260607
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72117479
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56988487
6Mismatch repair_Homo sapiens_hsa034302.22610051
7Spliceosome_Homo sapiens_hsa030402.10398629
8mRNA surveillance pathway_Homo sapiens_hsa030152.02988437
9MicroRNAs in cancer_Homo sapiens_hsa052062.02911024
10p53 signaling pathway_Homo sapiens_hsa041151.94329043
11* Oocyte meiosis_Homo sapiens_hsa041141.88380773
12Systemic lupus erythematosus_Homo sapiens_hsa053221.87586625
13* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.86047339
14RNA degradation_Homo sapiens_hsa030181.82948892
15* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.81006957
16One carbon pool by folate_Homo sapiens_hsa006701.72597174
17Fanconi anemia pathway_Homo sapiens_hsa034601.70397031
18Non-homologous end-joining_Homo sapiens_hsa034501.69188022
19Adherens junction_Homo sapiens_hsa045201.65782853
20Base excision repair_Homo sapiens_hsa034101.65057296
21Viral carcinogenesis_Homo sapiens_hsa052031.60147738
22Homologous recombination_Homo sapiens_hsa034401.57668597
23Nucleotide excision repair_Homo sapiens_hsa034201.57657171
24TGF-beta signaling pathway_Homo sapiens_hsa043501.52679375
25N-Glycan biosynthesis_Homo sapiens_hsa005101.52615218
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50597629
27Chronic myeloid leukemia_Homo sapiens_hsa052201.47769698
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47196491
29Small cell lung cancer_Homo sapiens_hsa052221.45716549
30Hippo signaling pathway_Homo sapiens_hsa043901.37853004
31mTOR signaling pathway_Homo sapiens_hsa041501.35767671
32Basal transcription factors_Homo sapiens_hsa030221.32723001
33* HTLV-I infection_Homo sapiens_hsa051661.28782356
34Colorectal cancer_Homo sapiens_hsa052101.27381884
35Proteoglycans in cancer_Homo sapiens_hsa052051.26689958
36Sphingolipid metabolism_Homo sapiens_hsa006001.24616071
37Basal cell carcinoma_Homo sapiens_hsa052171.23946272
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19995273
39Endometrial cancer_Homo sapiens_hsa052131.15919051
40Prostate cancer_Homo sapiens_hsa052151.14006568
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13061394
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11304791
43Pancreatic cancer_Homo sapiens_hsa052121.08048837
44Epstein-Barr virus infection_Homo sapiens_hsa051691.06798131
45Thyroid cancer_Homo sapiens_hsa052161.04385903
46Alcoholism_Homo sapiens_hsa050341.03824508
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.02784213
48Focal adhesion_Homo sapiens_hsa045101.02337637
49Pyruvate metabolism_Homo sapiens_hsa006201.00556041
50Dorso-ventral axis formation_Homo sapiens_hsa043200.98823058
51Viral myocarditis_Homo sapiens_hsa054160.97863000
52Glioma_Homo sapiens_hsa052140.97375223
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97196678
54Herpes simplex infection_Homo sapiens_hsa051680.95406671
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.93756882
56Non-small cell lung cancer_Homo sapiens_hsa052230.93316576
57RNA polymerase_Homo sapiens_hsa030200.92559680
58FoxO signaling pathway_Homo sapiens_hsa040680.91726470
59Hedgehog signaling pathway_Homo sapiens_hsa043400.91570139
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91499272
61Wnt signaling pathway_Homo sapiens_hsa043100.90909189
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90296396
63Hepatitis B_Homo sapiens_hsa051610.89765987
64Antigen processing and presentation_Homo sapiens_hsa046120.88010930
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86985774
66Renal cell carcinoma_Homo sapiens_hsa052110.83462752
67Biosynthesis of amino acids_Homo sapiens_hsa012300.83451343
68Pathways in cancer_Homo sapiens_hsa052000.82447896
69ECM-receptor interaction_Homo sapiens_hsa045120.81490369
70Melanoma_Homo sapiens_hsa052180.79904438
71Fatty acid biosynthesis_Homo sapiens_hsa000610.79389884
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77160606
73Bladder cancer_Homo sapiens_hsa052190.74314233
74Lysine degradation_Homo sapiens_hsa003100.73995374
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73392759
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72654379
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69893013
78HIF-1 signaling pathway_Homo sapiens_hsa040660.69768372
79Tight junction_Homo sapiens_hsa045300.66178031
80Inositol phosphate metabolism_Homo sapiens_hsa005620.65402282
81Glucagon signaling pathway_Homo sapiens_hsa049220.65227428
82Selenocompound metabolism_Homo sapiens_hsa004500.64177372
83Pyrimidine metabolism_Homo sapiens_hsa002400.63277106
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.62965422
85Vitamin B6 metabolism_Homo sapiens_hsa007500.62393493
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61610698
87Dilated cardiomyopathy_Homo sapiens_hsa054140.61004170
88Estrogen signaling pathway_Homo sapiens_hsa049150.60360430
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58021847
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57738114
91Purine metabolism_Homo sapiens_hsa002300.57436811
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57203114
93Notch signaling pathway_Homo sapiens_hsa043300.56711166
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56490236
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54404145
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53443549
97Platelet activation_Homo sapiens_hsa046110.53042719
98Melanogenesis_Homo sapiens_hsa049160.52565893
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52452100
100AMPK signaling pathway_Homo sapiens_hsa041520.52083739
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.49985316
102Prolactin signaling pathway_Homo sapiens_hsa049170.49250887
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48706669
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47122018
105Shigellosis_Homo sapiens_hsa051310.47091250
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.46107385
107Carbon metabolism_Homo sapiens_hsa012000.45619254
108VEGF signaling pathway_Homo sapiens_hsa043700.44590186
109Gap junction_Homo sapiens_hsa045400.43583462
110ErbB signaling pathway_Homo sapiens_hsa040120.42855767
111Toxoplasmosis_Homo sapiens_hsa051450.42611145
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42068359
113Rap1 signaling pathway_Homo sapiens_hsa040150.42005532
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41912316
115TNF signaling pathway_Homo sapiens_hsa046680.41431195
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38985533
117Insulin signaling pathway_Homo sapiens_hsa049100.38556658
118MAPK signaling pathway_Homo sapiens_hsa040100.37860010
119Circadian rhythm_Homo sapiens_hsa047100.37421340
120Insulin resistance_Homo sapiens_hsa049310.37020584
121Influenza A_Homo sapiens_hsa051640.36776694
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36591644
123Apoptosis_Homo sapiens_hsa042100.36444339
124Proteasome_Homo sapiens_hsa030500.35326975
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34928056
126Amoebiasis_Homo sapiens_hsa051460.34176282
127Steroid biosynthesis_Homo sapiens_hsa001000.33938463
128Choline metabolism in cancer_Homo sapiens_hsa052310.33582176

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