CDC25A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.02906966
2protein localization to kinetochore (GO:0034501)4.75874948
3nuclear pore organization (GO:0006999)4.52075904
4establishment of integrated proviral latency (GO:0075713)4.50988918
5nuclear pore complex assembly (GO:0051292)4.49008022
6DNA replication initiation (GO:0006270)4.43370947
7DNA strand elongation involved in DNA replication (GO:0006271)4.27662956
8DNA replication checkpoint (GO:0000076)4.20419483
9DNA replication-dependent nucleosome assembly (GO:0006335)4.15668101
10DNA replication-dependent nucleosome organization (GO:0034723)4.15668101
11mitotic nuclear envelope disassembly (GO:0007077)4.15538842
12protein localization to chromosome, centromeric region (GO:0071459)4.08599591
13DNA strand elongation (GO:0022616)4.06627985
14mitotic metaphase plate congression (GO:0007080)4.00116581
15mitotic sister chromatid segregation (GO:0000070)3.91279371
16formation of translation preinitiation complex (GO:0001731)3.89988107
17protein complex localization (GO:0031503)3.89509891
18nuclear envelope disassembly (GO:0051081)3.86222163
19membrane disassembly (GO:0030397)3.86222163
20mitotic chromosome condensation (GO:0007076)3.85996564
21folic acid-containing compound biosynthetic process (GO:0009396)3.83996752
22sister chromatid segregation (GO:0000819)3.78829529
23nucleobase biosynthetic process (GO:0046112)3.74982902
24mitotic sister chromatid cohesion (GO:0007064)3.72644818
25maturation of SSU-rRNA (GO:0030490)3.71172221
26DNA topological change (GO:0006265)3.70014328
27telomere maintenance via semi-conservative replication (GO:0032201)3.62597053
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59506390
29DNA duplex unwinding (GO:0032508)3.54962805
30kinetochore organization (GO:0051383)3.54483641
31DNA geometric change (GO:0032392)3.54110865
32pre-miRNA processing (GO:0031054)3.53914942
33heterochromatin organization (GO:0070828)3.50248512
34IMP biosynthetic process (GO:0006188)3.50138175
35metaphase plate congression (GO:0051310)3.49630400
36cellular protein complex localization (GO:0034629)3.48737979
37pore complex assembly (GO:0046931)3.45488731
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42205575
39regulation of gene silencing by RNA (GO:0060966)3.36230386
40regulation of posttranscriptional gene silencing (GO:0060147)3.36230386
41regulation of gene silencing by miRNA (GO:0060964)3.36230386
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34486493
43purine nucleobase biosynthetic process (GO:0009113)3.33263880
44mitotic recombination (GO:0006312)3.33014433
45double-strand break repair via nonhomologous end joining (GO:0006303)3.30592871
46non-recombinational repair (GO:0000726)3.30592871
47telomere maintenance via recombination (GO:0000722)3.30578761
48regulation of histone H3-K9 methylation (GO:0051570)3.30302930
49L-serine metabolic process (GO:0006563)3.28378577
50establishment of viral latency (GO:0019043)3.28182108
51positive regulation of chromosome segregation (GO:0051984)3.27350393
52ribosome assembly (GO:0042255)3.26990495
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26879216
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.26879216
55chromatin remodeling at centromere (GO:0031055)3.24390796
56ribosomal small subunit assembly (GO:0000028)3.22713113
57ATP-dependent chromatin remodeling (GO:0043044)3.21937886
58DNA synthesis involved in DNA repair (GO:0000731)3.21795431
59regulation of spindle organization (GO:0090224)3.21206768
60DNA replication-independent nucleosome organization (GO:0034724)3.20596639
61DNA replication-independent nucleosome assembly (GO:0006336)3.20596639
62attachment of spindle microtubules to kinetochore (GO:0008608)3.18148858
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17262221
64establishment of chromosome localization (GO:0051303)3.16873704
65CENP-A containing nucleosome assembly (GO:0034080)3.15939863
66regulation of sister chromatid cohesion (GO:0007063)3.15857098
67viral transcription (GO:0019083)3.14961381
68translational termination (GO:0006415)3.14435128
69negative regulation of histone methylation (GO:0031061)3.12738252
70DNA ligation (GO:0006266)3.12002357
71chromatin assembly or disassembly (GO:0006333)3.11516768
72regulation of chromosome segregation (GO:0051983)3.10611600
73protein localization to chromosome (GO:0034502)3.10139913
74translational initiation (GO:0006413)3.09036500
75regulation of centriole replication (GO:0046599)3.08577154
76kinetochore assembly (GO:0051382)3.07387104
77DNA conformation change (GO:0071103)3.06765894
78negative regulation of mRNA metabolic process (GO:1903312)3.06533090
79DNA packaging (GO:0006323)3.06487502
80chromatin assembly (GO:0031497)3.04756042
81regulation of helicase activity (GO:0051095)3.04418944
82nuclear envelope organization (GO:0006998)3.03542025
83telomere maintenance via telomere lengthening (GO:0010833)3.01656216
84IMP metabolic process (GO:0046040)3.01580704
85chromosome condensation (GO:0030261)3.00588417
86meiotic chromosome segregation (GO:0045132)3.00200093
87negative regulation of chromosome segregation (GO:0051985)2.98013137
88protein K6-linked ubiquitination (GO:0085020)2.96608176
89negative regulation of RNA splicing (GO:0033119)2.96480049
90spindle checkpoint (GO:0031577)2.96302799
91regulation of mitotic sister chromatid separation (GO:0010965)2.95193362
92regulation of mitotic sister chromatid segregation (GO:0033047)2.95193362
93regulation of sister chromatid segregation (GO:0033045)2.95193362
94regulation of translational termination (GO:0006449)2.95138546
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94389078
96histone exchange (GO:0043486)2.93783296
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.93335580
98regulation of RNA export from nucleus (GO:0046831)2.93166251
99regulation of centrosome cycle (GO:0046605)2.92132931
100ribosomal small subunit biogenesis (GO:0042274)2.92122634
101ribosomal large subunit biogenesis (GO:0042273)2.91279220
102ribosome biogenesis (GO:0042254)2.89737333
103negative regulation of mRNA processing (GO:0050686)2.89497108
104translesion synthesis (GO:0019985)2.89119428
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.88980324
106negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88980324
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88980324
108negative regulation of sister chromatid segregation (GO:0033046)2.88980324
109chromosome segregation (GO:0007059)2.86918953
110ribonucleoprotein complex biogenesis (GO:0022613)2.86298992
111regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86203306
112spindle assembly checkpoint (GO:0071173)2.85280526
113mismatch repair (GO:0006298)2.85044261
114regulation of translational fidelity (GO:0006450)2.84956314
115translational elongation (GO:0006414)2.84181773
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83712783
117mitotic spindle checkpoint (GO:0071174)2.82772860
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82196048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human9.68249394
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.89037636
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.98183473
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.89025583
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35705332
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24320021
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98043066
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65445245
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.59052623
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44357901
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.40863854
12* AR_21909140_ChIP-Seq_LNCAP_Human2.29574982
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.29078469
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20695778
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17845700
16XRN2_22483619_ChIP-Seq_HELA_Human2.16791623
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.15429781
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.15349905
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13354962
20* MYC_22102868_ChIP-Seq_BL_Human2.05087701
21* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01272162
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92492407
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90736783
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.90642906
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90178086
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88159748
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80344471
28VDR_23849224_ChIP-Seq_CD4+_Human1.79315273
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77607932
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70567159
31* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68455292
32TTF2_22483619_ChIP-Seq_HELA_Human1.68238052
33FOXP3_21729870_ChIP-Seq_TREG_Human1.65691557
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63801172
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.63277722
36DCP1A_22483619_ChIP-Seq_HELA_Human1.59344098
37CIITA_25753668_ChIP-Seq_RAJI_Human1.59281794
38GABP_19822575_ChIP-Seq_HepG2_Human1.58218088
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49279523
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48349753
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47887506
42KDM5A_27292631_Chip-Seq_BREAST_Human1.47676649
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45856590
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40547563
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37874496
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35711310
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33842683
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32960772
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32960772
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32960772
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32634401
52* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32356185
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30653165
54ELK1_19687146_ChIP-ChIP_HELA_Human1.29067402
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26923329
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25319332
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24351697
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23166907
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.22750985
60VDR_21846776_ChIP-Seq_THP-1_Human1.22605884
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20002935
62* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18364806
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.17760168
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16942405
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.15268888
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15114402
67* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14675874
68* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14655988
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14042294
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13292831
71* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12273292
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12126380
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10072243
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.09313337
75TFEB_21752829_ChIP-Seq_HELA_Human1.09308624
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08165965
77* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07907962
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.04615911
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04471459
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04177452
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02708338
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01412620
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01017235
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00582536
85ZNF263_19887448_ChIP-Seq_K562_Human1.00562747
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00489754
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99872959
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98616164
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96702144
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96523690
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96473625
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.92747849
93* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91710731
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.91070349
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89143297
96CHD1_26751641_Chip-Seq_LNCaP_Human0.88900703
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88820184
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87232210
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85852572
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85190931
101* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85183401
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84784917
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84296549
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81539144
105MYC_18940864_ChIP-ChIP_HL60_Human0.81418956
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79479261
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77633250
108* SRF_21415370_ChIP-Seq_HL-1_Mouse0.77500912
109* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76543558
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.76386797
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76344767
112* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76326984
113* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76071613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003693_abnormal_embryo_hatching4.39184879
2MP0010094_abnormal_chromosome_stability4.24361750
3* MP0003111_abnormal_nucleus_morphology4.07974872
4MP0008057_abnormal_DNA_replication3.88373794
5* MP0004957_abnormal_blastocyst_morpholog3.84741676
6* MP0003077_abnormal_cell_cycle3.49812283
7MP0003123_paternal_imprinting3.13983000
8MP0010352_gastrointestinal_tract_polyps2.76325355
9MP0008058_abnormal_DNA_repair2.59665171
10MP0001730_embryonic_growth_arrest2.42158758
11MP0008932_abnormal_embryonic_tissue2.32532144
12MP0008007_abnormal_cellular_replicative2.21792722
13* MP0000350_abnormal_cell_proliferation2.17830928
14MP0005076_abnormal_cell_differentiation1.95922248
15* MP0005380_embryogenesis_phenotype1.95082226
16* MP0001672_abnormal_embryogenesis/_devel1.95082226
17MP0002396_abnormal_hematopoietic_system1.90340015
18MP0010307_abnormal_tumor_latency1.90005910
19MP0003121_genomic_imprinting1.89646075
20MP0008877_abnormal_DNA_methylation1.87622334
21MP0001697_abnormal_embryo_size1.82161486
22MP0010030_abnormal_orbit_morphology1.77475677
23MP0004197_abnormal_fetal_growth/weight/1.77138012
24MP0002084_abnormal_developmental_patter1.76610507
25* MP0002085_abnormal_embryonic_tissue1.76307306
26* MP0003984_embryonic_growth_retardation1.75228836
27* MP0002088_abnormal_embryonic_growth/wei1.73508038
28* MP0000490_abnormal_crypts_of1.68448856
29MP0002086_abnormal_extraembryonic_tissu1.64933936
30MP0001346_abnormal_lacrimal_gland1.61832356
31* MP0002080_prenatal_lethality1.60135518
32MP0004264_abnormal_extraembryonic_tissu1.59978794
33MP0003890_abnormal_embryonic-extraembry1.58637813
34MP0009697_abnormal_copulation1.52335703
35MP0003786_premature_aging1.51616400
36MP0003705_abnormal_hypodermis_morpholog1.47920758
37MP0003567_abnormal_fetal_cardiomyocyte1.44168264
38MP0000537_abnormal_urethra_morphology1.43590737
39MP0009379_abnormal_foot_pigmentation1.40574216
40MP0002653_abnormal_ependyma_morphology1.34937487
41MP0004185_abnormal_adipocyte_glucose1.34474455
42MP0003119_abnormal_digestive_system1.32209060
43MP0001293_anophthalmia1.31470140
44MP0004808_abnormal_hematopoietic_stem1.30894083
45* MP0000313_abnormal_cell_death1.29917204
46MP0006054_spinal_hemorrhage1.25330853
47MP0003315_abnormal_perineum_morphology1.22377086
48MP0009053_abnormal_anal_canal1.21720877
49* MP0002019_abnormal_tumor_incidence1.20328866
50MP0002210_abnormal_sex_determination1.18117043
51MP0002009_preneoplasia1.17062610
52MP0004233_abnormal_muscle_weight1.11090770
53MP0003718_maternal_effect1.10697086
54MP0001145_abnormal_male_reproductive1.08164640
55MP0001929_abnormal_gametogenesis1.04309412
56MP0003937_abnormal_limbs/digits/tail_de1.03351699
57MP0006035_abnormal_mitochondrial_morpho1.02475496
58MP0009672_abnormal_birth_weight1.01295349
59MP0009278_abnormal_bone_marrow1.01254008
60MP0005623_abnormal_meninges_morphology0.98948208
61MP0009333_abnormal_splenocyte_physiolog0.98030903
62MP0000049_abnormal_middle_ear0.96046159
63MP0001849_ear_inflammation0.95864265
64MP0009703_decreased_birth_body0.95683561
65MP0002233_abnormal_nose_morphology0.94103685
66MP0000703_abnormal_thymus_morphology0.93332445
67MP0000653_abnormal_sex_gland0.93041420
68MP0000428_abnormal_craniofacial_morphol0.92339058
69MP0003941_abnormal_skin_development0.91217476
70MP0002111_abnormal_tail_morphology0.88258214
71MP0003942_abnormal_urinary_system0.88139846
72MP0005187_abnormal_penis_morphology0.87521992
73MP0002092_abnormal_eye_morphology0.86845191
74MP0000358_abnormal_cell_content/0.86554100
75MP0001915_intracranial_hemorrhage0.86004839
76MP0005023_abnormal_wound_healing0.85454634
77MP0001545_abnormal_hematopoietic_system0.85018883
78MP0005397_hematopoietic_system_phenotyp0.85018883
79MP0010234_abnormal_vibrissa_follicle0.84175503
80MP0002877_abnormal_melanocyte_morpholog0.83976977
81MP0000432_abnormal_head_morphology0.83470567
82MP0004133_heterotaxia0.81920596
83MP0003763_abnormal_thymus_physiology0.81775633
84MP0005501_abnormal_skin_physiology0.81583257
85MP0001286_abnormal_eye_development0.81350456
86MP0001661_extended_life_span0.81002870
87* MP0000477_abnormal_intestine_morphology0.79401246
88MP0003566_abnormal_cell_adhesion0.79123027
89MP0003115_abnormal_respiratory_system0.76447153
90MP0001188_hyperpigmentation0.75239326
91MP0002398_abnormal_bone_marrow0.74955435
92MP0001119_abnormal_female_reproductive0.74471776
93MP0002722_abnormal_immune_system0.74154052
94MP0002697_abnormal_eye_size0.73980315
95MP0005384_cellular_phenotype0.73422504
96MP0003935_abnormal_craniofacial_develop0.72299146
97MP0003699_abnormal_female_reproductive0.71701631
98MP0002081_perinatal_lethality0.71474608
99MP0000733_abnormal_muscle_development0.70866739
100MP0000858_altered_metastatic_potential0.70817214
101MP0002925_abnormal_cardiovascular_devel0.70201018
102MP0005621_abnormal_cell_physiology0.69759594
103MP0002938_white_spotting0.69352811
104MP0002161_abnormal_fertility/fecundity0.68432468
105MP0003136_yellow_coat_color0.68287612
106MP0000579_abnormal_nail_morphology0.68176198
107MP0008995_early_reproductive_senescence0.67612688
108MP0003755_abnormal_palate_morphology0.67019938
109MP0003385_abnormal_body_wall0.65618995
110MP0000689_abnormal_spleen_morphology0.65455140
111MP0002796_impaired_skin_barrier0.64652369
112MP0002932_abnormal_joint_morphology0.64264429
113MP0003938_abnormal_ear_development0.64022794
114MP0000762_abnormal_tongue_morphology0.62901486
115MP0002163_abnormal_gland_morphology0.62713736
116MP0003283_abnormal_digestive_organ0.62671950
117MP0002234_abnormal_pharynx_morphology0.62326342
118MP0006292_abnormal_olfactory_placode0.61842089
119MP0002160_abnormal_reproductive_system0.60707316
120MP0000566_synostosis0.60192291
121MP0002282_abnormal_trachea_morphology0.60031245
122MP0003861_abnormal_nervous_system0.59262744
123MP0008770_decreased_survivor_rate0.58597221
124MP0003122_maternal_imprinting0.57996713
125MP0002114_abnormal_axial_skeleton0.57608019
126MP0003221_abnormal_cardiomyocyte_apopto0.57062789
127MP0002249_abnormal_larynx_morphology0.56882839

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.63523964
2Reticulocytopenia (HP:0001896)3.63240144
3Birth length less than 3rd percentile (HP:0003561)3.50574610
4Medulloblastoma (HP:0002885)3.39657481
5Selective tooth agenesis (HP:0001592)3.36736725
6Chromsome breakage (HP:0040012)3.33603739
7Breast hypoplasia (HP:0003187)3.24419597
8Colon cancer (HP:0003003)3.23109860
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22256570
10Patellar aplasia (HP:0006443)3.07004927
11Impulsivity (HP:0100710)2.95916822
12Aplasia/Hypoplasia of the sacrum (HP:0008517)2.92724778
13Aplasia/Hypoplasia of the patella (HP:0006498)2.90809650
14Meckel diverticulum (HP:0002245)2.89533281
15Abnormality of chromosome stability (HP:0003220)2.83785731
16Multiple enchondromatosis (HP:0005701)2.82154698
17Abnormality of the ileum (HP:0001549)2.80266952
18Volvulus (HP:0002580)2.78814977
19Progressive muscle weakness (HP:0003323)2.76373833
20Abnormality of cells of the erythroid lineage (HP:0012130)2.76184246
21Rhabdomyosarcoma (HP:0002859)2.74919076
22Deviation of the thumb (HP:0009603)2.69322772
23Proximal placement of thumb (HP:0009623)2.69280949
24Absent radius (HP:0003974)2.65697808
25Cortical dysplasia (HP:0002539)2.61152779
26Abnormal number of incisors (HP:0011064)2.60742850
27Increased nuchal translucency (HP:0010880)2.58396698
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57961700
29Short 4th metacarpal (HP:0010044)2.57961700
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.55741254
31Abnormal number of erythroid precursors (HP:0012131)2.54868417
32Microvesicular hepatic steatosis (HP:0001414)2.53553905
33Abnormality of the preputium (HP:0100587)2.51770920
34Absent thumb (HP:0009777)2.50538909
35Degeneration of anterior horn cells (HP:0002398)2.49360256
36Abnormality of the anterior horn cell (HP:0006802)2.49360256
37Absent forearm bone (HP:0003953)2.48999779
38Aplasia involving forearm bones (HP:0009822)2.48999779
39Duplication of thumb phalanx (HP:0009942)2.45019405
4011 pairs of ribs (HP:0000878)2.43893533
41Abnormality of cochlea (HP:0000375)2.42600178
42Abnormality of the labia minora (HP:0012880)2.41078764
43Missing ribs (HP:0000921)2.40571160
44Ectopic kidney (HP:0000086)2.39791615
45Neoplasm of striated muscle (HP:0009728)2.39593583
46Myelodysplasia (HP:0002863)2.38525182
47Atresia of the external auditory canal (HP:0000413)2.38337356
48Astrocytoma (HP:0009592)2.38310345
49Abnormality of the astrocytes (HP:0100707)2.38310345
50Carpal bone hypoplasia (HP:0001498)2.37544013
51Basal cell carcinoma (HP:0002671)2.37477390
52Agnosia (HP:0010524)2.37429360
53Small intestinal stenosis (HP:0012848)2.35799415
54Duodenal stenosis (HP:0100867)2.35799415
55Supernumerary spleens (HP:0009799)2.31441084
56Aplasia/hypoplasia of the humerus (HP:0006507)2.29623962
57Neoplasm of the pancreas (HP:0002894)2.26292233
58Facial cleft (HP:0002006)2.22646619
59Nephroblastoma (Wilms tumor) (HP:0002667)2.20824206
60Progressive external ophthalmoplegia (HP:0000590)2.20234585
61Glioma (HP:0009733)2.19619826
62Overlapping toe (HP:0001845)2.19552598
63Rib fusion (HP:0000902)2.17526136
64Neoplasm of the oral cavity (HP:0100649)2.16917906
65Facial hemangioma (HP:0000329)2.16367883
66Tracheoesophageal fistula (HP:0002575)2.15061182
67Oral leukoplakia (HP:0002745)2.14072464
68Septate vagina (HP:0001153)2.11286703
69Short humerus (HP:0005792)2.08569145
70Aplastic anemia (HP:0001915)2.08006999
71Abnormality of the fingertips (HP:0001211)2.06592045
72Biliary tract neoplasm (HP:0100574)2.04421285
73Prominent nose (HP:0000448)2.03140847
74Hyperacusis (HP:0010780)2.02223090
75Embryonal renal neoplasm (HP:0011794)2.01888037
76Short middle phalanx of the 5th finger (HP:0004220)2.01842644
77Trismus (HP:0000211)2.01449081
78Abnormality of the duodenum (HP:0002246)2.00949751
79Cafe-au-lait spot (HP:0000957)2.00429278
80Choanal atresia (HP:0000453)2.00158180
81Rough bone trabeculation (HP:0100670)1.98215486
82Sloping forehead (HP:0000340)1.97941788
83Squamous cell carcinoma (HP:0002860)1.95599665
84Abnormality of the carotid arteries (HP:0005344)1.95566511
85Short thumb (HP:0009778)1.95363496
86Homocystinuria (HP:0002156)1.95095633
87Abnormality of homocysteine metabolism (HP:0010919)1.95095633
88Macrocytic anemia (HP:0001972)1.93837316
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.93299276
90High pitched voice (HP:0001620)1.92779651
91Abnormal lung lobation (HP:0002101)1.90938316
92Pallor (HP:0000980)1.90909933
93Septo-optic dysplasia (HP:0100842)1.90377484
94Renal duplication (HP:0000075)1.89984755
95Bone marrow hypocellularity (HP:0005528)1.89707853
96Malignant gastrointestinal tract tumors (HP:0006749)1.89636679
97Gastrointestinal carcinoma (HP:0002672)1.89636679
98Broad palm (HP:0001169)1.89155611
99Shawl scrotum (HP:0000049)1.87197621
100Supernumerary bones of the axial skeleton (HP:0009144)1.86314364
101Supernumerary ribs (HP:0005815)1.86209661
102Long eyelashes (HP:0000527)1.85863848
103Abnormality of chromosome segregation (HP:0002916)1.84950077
104Secondary amenorrhea (HP:0000869)1.82913666
105Skin tags (HP:0010609)1.82845144
106Spastic diplegia (HP:0001264)1.82433876
107Bilateral microphthalmos (HP:0007633)1.81743111
108Abnormality of abdominal situs (HP:0011620)1.80994255
109Abdominal situs inversus (HP:0003363)1.80994255
110Rectal fistula (HP:0100590)1.80824977
111Rectovaginal fistula (HP:0000143)1.80824977
112Overriding aorta (HP:0002623)1.80530733
113Preauricular skin tag (HP:0000384)1.80461499
114Abnormality of the 4th metacarpal (HP:0010012)1.79160622
115Amaurosis fugax (HP:0100576)1.78930838
116Premature graying of hair (HP:0002216)1.78321667
117Esophageal atresia (HP:0002032)1.78092520
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77943446
119Abnormality of the septum pellucidum (HP:0007375)1.77520607
120Thrombocytosis (HP:0001894)1.76613269
121Premature ovarian failure (HP:0008209)1.76299777
122Duplicated collecting system (HP:0000081)1.76177987
123Horseshoe kidney (HP:0000085)1.75189396
124Embryonal neoplasm (HP:0002898)1.74758336
125Broad distal phalanx of finger (HP:0009836)1.73151253
126High anterior hairline (HP:0009890)1.72321403
127Intestinal fistula (HP:0100819)1.72161226
128Triphalangeal thumb (HP:0001199)1.72145923
129Morphological abnormality of the inner ear (HP:0011390)1.71148712
130Abnormality of the phalanges of the hallux (HP:0010057)1.68467507
131Arteriovenous malformation (HP:0100026)1.68144241
132Abnormal umbilical cord blood vessels (HP:0011403)1.67731377
133Single umbilical artery (HP:0001195)1.67731377
134Abnormality of the fetal cardiovascular system (HP:0010948)1.67731377
135Vaginal fistula (HP:0004320)1.66935032
136Megaloblastic anemia (HP:0001889)1.65832426
137Skull defect (HP:0001362)1.64870653
138Dysphonia (HP:0001618)1.63877836
139Abnormality of reticulocytes (HP:0004312)1.63833735
140Cleft eyelid (HP:0000625)1.63448739
141Partial duplication of thumb phalanx (HP:0009944)1.62569899
142Urethral obstruction (HP:0000796)1.61734879
143Abnormality of the calcaneus (HP:0008364)1.58881316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.54189393
2WEE13.71845826
3BUB13.36208464
4NEK23.17754270
5CDK123.04976952
6TTK2.76386783
7SMG12.64999333
8SRPK12.44918007
9EEF2K2.42220005
10PBK2.41800539
11VRK22.27607517
12MAP3K102.17904021
13PASK2.14618414
14TSSK62.05655176
15RPS6KB22.01535173
16PLK11.96534611
17EIF2AK11.92319633
18CDK71.90226944
19TAF11.89268206
20NEK11.84113856
21PLK41.83963657
22CDK41.82680573
23ATR1.78037298
24BRSK21.71519674
25STK101.70943444
26AURKB1.70485352
27ACVR1B1.69397967
28MAP3K81.56298056
29MKNK11.53346793
30DYRK31.47927610
31TLK11.47893662
32LATS11.45961704
33* CHEK21.41260632
34EPHA21.40538346
35* CHEK11.39815943
36TESK21.37213421
37STK31.37081447
38PKN21.36168826
39STK161.32634298
40NME21.25585565
41MKNK21.22869379
42STK41.20412263
43RPS6KA41.18897087
44EIF2AK31.18892486
45BRD41.18327360
46TGFBR11.18313420
47PAK41.17758662
48SCYL21.14956915
49VRK11.12492034
50CDK61.08253125
51ALK1.07576879
52AURKA1.05288220
53* ATM1.04870983
54* PLK31.04574986
55LRRK21.00796064
56CAMK1G1.00171029
57* CDK20.99996067
58MTOR0.99039537
59MELK0.95838093
60NME10.95679465
61CAMK1D0.90655951
62TESK10.86930535
63MAP3K90.85941248
64LATS20.85260436
65BRAF0.83111420
66* PIM10.81714726
67BRSK10.77628087
68CDK80.77009500
69ICK0.75795886
70* CDK10.72142936
71FLT30.69570132
72MAP2K30.66580850
73CSNK2A20.64242580
74PRKCI0.64224761
75EIF2AK20.62437337
76PAK20.59455640
77PNCK0.58227394
78ERBB40.58211190
79IRAK30.57883087
80MAP4K10.57621572
81PAK10.57374901
82PDK20.56216978
83PRPF4B0.55963814
84AKT20.55950259
85ZAK0.55273903
86TRIB30.55071619
87CDK30.52045950
88PTK60.51162713
89CSNK1E0.50850247
90GRK60.50547546
91CSNK2A10.50513527
92MAP2K20.50505294
93CDK90.49878729
94CDK11A0.48571093
95STK38L0.47040230
96TRIM280.46044321
97CDK150.45081622
98CLK10.41294995
99CDK180.41192281
100FGFR10.41057354
101DYRK20.40973297
102* PRKDC0.39171768
103KSR20.39094503
104MAPK140.38981148
105MAPKAPK30.38642865
106AKT10.38291374
107PDK30.37740862
108PDK40.37740862
109CSNK1D0.37175204
110PIM20.37063186
111MAP3K110.36859943
112STK240.36182320
113CDK140.35900178
114BMX0.35618259
115RAF10.34654713
116TNIK0.32240590
117CSNK1G10.31447053
118MAPK10.30489049
119TTN0.30280387
120DMPK0.30149710
121MST40.29522954
122RPS6KA50.28526353
123TYRO30.28487117
124MAP3K30.27267637
125KDR0.27076413
126MAP3K60.26640445
127MAPK110.23524183
128ZAP700.23486049
129BTK0.22898276
130* GSK3B0.22870748
131PDGFRA0.22089967
132JAK30.20511794

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61617516
2Mismatch repair_Homo sapiens_hsa034304.09695919
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47435942
4RNA transport_Homo sapiens_hsa030133.33334592
5Spliceosome_Homo sapiens_hsa030403.24131715
6* Cell cycle_Homo sapiens_hsa041103.06449180
7Base excision repair_Homo sapiens_hsa034102.86512016
8One carbon pool by folate_Homo sapiens_hsa006702.79262792
9Ribosome_Homo sapiens_hsa030102.78396448
10Homologous recombination_Homo sapiens_hsa034402.73865120
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52309390
12Nucleotide excision repair_Homo sapiens_hsa034202.51066818
13RNA polymerase_Homo sapiens_hsa030202.49963132
14Fanconi anemia pathway_Homo sapiens_hsa034602.24891140
15mRNA surveillance pathway_Homo sapiens_hsa030152.18452709
16Non-homologous end-joining_Homo sapiens_hsa034502.04958409
17Pyrimidine metabolism_Homo sapiens_hsa002402.00723411
18Proteasome_Homo sapiens_hsa030501.93471834
19RNA degradation_Homo sapiens_hsa030181.86611242
20p53 signaling pathway_Homo sapiens_hsa041151.80389113
21Basal transcription factors_Homo sapiens_hsa030221.74533765
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38524013
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27406417
24Systemic lupus erythematosus_Homo sapiens_hsa053221.21323248
25Viral carcinogenesis_Homo sapiens_hsa052031.20845395
26Epstein-Barr virus infection_Homo sapiens_hsa051691.15341764
27Oocyte meiosis_Homo sapiens_hsa041141.13852500
28* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05978350
29Antigen processing and presentation_Homo sapiens_hsa046121.04212858
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03695537
31Pyruvate metabolism_Homo sapiens_hsa006201.02409574
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00883034
33* MicroRNAs in cancer_Homo sapiens_hsa052061.00365596
34Herpes simplex infection_Homo sapiens_hsa051680.99263477
35HTLV-I infection_Homo sapiens_hsa051660.95481605
36Purine metabolism_Homo sapiens_hsa002300.94935156
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93580868
38Small cell lung cancer_Homo sapiens_hsa052220.93014395
39Pentose phosphate pathway_Homo sapiens_hsa000300.91769225
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89945949
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88435668
42Hippo signaling pathway_Homo sapiens_hsa043900.84443735
43Notch signaling pathway_Homo sapiens_hsa043300.83954656
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83627504
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82691791
46Basal cell carcinoma_Homo sapiens_hsa052170.82627840
47Selenocompound metabolism_Homo sapiens_hsa004500.81054618
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.80816593
49Huntingtons disease_Homo sapiens_hsa050160.80185327
50Thyroid cancer_Homo sapiens_hsa052160.79498194
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78549376
52TGF-beta signaling pathway_Homo sapiens_hsa043500.78182886
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76051414
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71681361
55Biosynthesis of amino acids_Homo sapiens_hsa012300.70432613
56Chronic myeloid leukemia_Homo sapiens_hsa052200.70399544
57Colorectal cancer_Homo sapiens_hsa052100.70295425
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67537391
59Steroid biosynthesis_Homo sapiens_hsa001000.63142483
60Parkinsons disease_Homo sapiens_hsa050120.62992528
61Legionellosis_Homo sapiens_hsa051340.61281132
62Adherens junction_Homo sapiens_hsa045200.61062048
63Renin-angiotensin system_Homo sapiens_hsa046140.60671896
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60544440
65mTOR signaling pathway_Homo sapiens_hsa041500.59842029
66Bladder cancer_Homo sapiens_hsa052190.58515968
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.56926468
68Hedgehog signaling pathway_Homo sapiens_hsa043400.56620614
69Lysine degradation_Homo sapiens_hsa003100.54997210
70Prostate cancer_Homo sapiens_hsa052150.54763777
71Vitamin B6 metabolism_Homo sapiens_hsa007500.54257905
72Apoptosis_Homo sapiens_hsa042100.54124791
73Folate biosynthesis_Homo sapiens_hsa007900.53470222
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52676351
75N-Glycan biosynthesis_Homo sapiens_hsa005100.50098282
76Hepatitis B_Homo sapiens_hsa051610.48561899
77Pathways in cancer_Homo sapiens_hsa052000.45667219
78Fructose and mannose metabolism_Homo sapiens_hsa000510.44884229
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.43484265
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.42767177
81Glutathione metabolism_Homo sapiens_hsa004800.41832791
82Alcoholism_Homo sapiens_hsa050340.40697480
83HIF-1 signaling pathway_Homo sapiens_hsa040660.39599370
84Viral myocarditis_Homo sapiens_hsa054160.39543022
85Acute myeloid leukemia_Homo sapiens_hsa052210.38011707
86Oxidative phosphorylation_Homo sapiens_hsa001900.37778302
87Shigellosis_Homo sapiens_hsa051310.37703156
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36931483
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36650052
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36174057
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35573461
92Wnt signaling pathway_Homo sapiens_hsa043100.33439787
93Proteoglycans in cancer_Homo sapiens_hsa052050.33415333
94Pancreatic cancer_Homo sapiens_hsa052120.33063101
95Arginine and proline metabolism_Homo sapiens_hsa003300.32396778
96Fat digestion and absorption_Homo sapiens_hsa049750.31993125
97Galactose metabolism_Homo sapiens_hsa000520.31889200
98Non-small cell lung cancer_Homo sapiens_hsa052230.31843553
99Tight junction_Homo sapiens_hsa045300.31648076
100Primary immunodeficiency_Homo sapiens_hsa053400.31437752
101Influenza A_Homo sapiens_hsa051640.31150292
102Measles_Homo sapiens_hsa051620.30496896
103Protein export_Homo sapiens_hsa030600.29903678
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.29353580
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28698952
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27652222
107Metabolic pathways_Homo sapiens_hsa011000.26659222
108Endometrial cancer_Homo sapiens_hsa052130.26503425
109Fatty acid elongation_Homo sapiens_hsa000620.24956080
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.24616913
111Sulfur relay system_Homo sapiens_hsa041220.24265657
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23402929
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23131097
114Carbon metabolism_Homo sapiens_hsa012000.22986747
115FoxO signaling pathway_Homo sapiens_hsa040680.22088239
116Glioma_Homo sapiens_hsa052140.19673485
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19360826
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18944583
119Melanoma_Homo sapiens_hsa052180.18199748
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17620673
121Protein digestion and absorption_Homo sapiens_hsa049740.17269056
122Arginine biosynthesis_Homo sapiens_hsa002200.16579563
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16151737
124Alzheimers disease_Homo sapiens_hsa050100.14246552
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14069485

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