CDC23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.77113958
2establishment of integrated proviral latency (GO:0075713)4.65732766
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.25660297
4protein localization to kinetochore (GO:0034501)4.11231886
5nuclear pore organization (GO:0006999)4.09284616
6IMP biosynthetic process (GO:0006188)4.07308072
7DNA ligation (GO:0006266)4.03563909
8DNA replication initiation (GO:0006270)3.99652027
9DNA strand elongation involved in DNA replication (GO:0006271)3.97031298
10ribosome assembly (GO:0042255)3.89447187
11kinetochore organization (GO:0051383)3.88678729
12nuclear pore complex assembly (GO:0051292)3.88466880
13DNA strand elongation (GO:0022616)3.82319023
14mitotic sister chromatid segregation (GO:0000070)3.80887063
15sister chromatid segregation (GO:0000819)3.80614891
16non-recombinational repair (GO:0000726)3.79989057
17double-strand break repair via nonhomologous end joining (GO:0006303)3.79989057
18mitotic nuclear envelope disassembly (GO:0007077)3.79579644
19nucleobase biosynthetic process (GO:0046112)3.77308930
20proteasome assembly (GO:0043248)3.76322585
21telomere maintenance via semi-conservative replication (GO:0032201)3.62766096
22cullin deneddylation (GO:0010388)3.62247771
23establishment of viral latency (GO:0019043)3.57664489
24purine nucleobase biosynthetic process (GO:0009113)3.53980939
25membrane disassembly (GO:0030397)3.52020206
26nuclear envelope disassembly (GO:0051081)3.52020206
27mitotic chromosome condensation (GO:0007076)3.50259187
28* mitotic metaphase plate congression (GO:0007080)3.49342267
29kinetochore assembly (GO:0051382)3.48491063
30negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.48426538
31CENP-A containing nucleosome assembly (GO:0034080)3.46690960
32mitotic recombination (GO:0006312)3.44238785
33DNA replication-dependent nucleosome assembly (GO:0006335)3.42261630
34DNA replication-dependent nucleosome organization (GO:0034723)3.42261630
35regulation of spindle organization (GO:0090224)3.42088359
36protein deneddylation (GO:0000338)3.41867209
37DNA replication checkpoint (GO:0000076)3.39875761
38DNA double-strand break processing (GO:0000729)3.39821837
39protein localization to chromosome, centromeric region (GO:0071459)3.39508764
40chromatin remodeling at centromere (GO:0031055)3.37753081
41DNA duplex unwinding (GO:0032508)3.35067124
42telomere maintenance via recombination (GO:0000722)3.34713721
43IMP metabolic process (GO:0046040)3.34612008
44somatic hypermutation of immunoglobulin genes (GO:0016446)3.34557678
45somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34557678
46DNA geometric change (GO:0032392)3.33263857
47histone H2A acetylation (GO:0043968)3.32342321
48* metaphase plate congression (GO:0051310)3.31176459
49DNA replication-independent nucleosome assembly (GO:0006336)3.30102071
50DNA replication-independent nucleosome organization (GO:0034724)3.30102071
51* spindle assembly checkpoint (GO:0071173)3.30054712
52formation of translation preinitiation complex (GO:0001731)3.29645973
53* negative regulation of chromosome segregation (GO:0051985)3.28647511
54* negative regulation of mitotic sister chromatid separation (GO:2000816)3.28099380
55* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.28099380
56* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.28099380
57* negative regulation of sister chromatid segregation (GO:0033046)3.28099380
58* mitotic spindle assembly checkpoint (GO:0007094)3.27722416
59* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26597540
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23782142
61tRNA aminoacylation for protein translation (GO:0006418)3.22887452
62peptidyl-arginine omega-N-methylation (GO:0035247)3.22261906
63* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21646481
64amino acid activation (GO:0043038)3.20161329
65tRNA aminoacylation (GO:0043039)3.20161329
66* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19466772
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.18059779
68regulation of DNA damage checkpoint (GO:2000001)3.17955490
69* spindle checkpoint (GO:0031577)3.17847777
70* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16229736
71DNA topological change (GO:0006265)3.15380242
72attachment of spindle microtubules to kinetochore (GO:0008608)3.15178851
73regulation of helicase activity (GO:0051095)3.12389550
74telomere maintenance via telomere lengthening (GO:0010833)3.11056563
75* mitotic spindle checkpoint (GO:0071174)3.10509220
76* establishment of chromosome localization (GO:0051303)3.10488591
77DNA catabolic process, exonucleolytic (GO:0000738)3.10210751
78mitotic sister chromatid cohesion (GO:0007064)3.09929486
79pre-miRNA processing (GO:0031054)3.09033343
80* regulation of chromosome segregation (GO:0051983)3.08795000
81* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07546609
82viral mRNA export from host cell nucleus (GO:0046784)3.07219487
83negative regulation of RNA splicing (GO:0033119)3.05567950
84* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01951587
85resolution of meiotic recombination intermediates (GO:0000712)3.01886537
86* regulation of sister chromatid segregation (GO:0033045)3.01223952
87* regulation of mitotic sister chromatid separation (GO:0010965)3.01223952
88* regulation of mitotic sister chromatid segregation (GO:0033047)3.01223952
89regulation of mitotic spindle organization (GO:0060236)2.99971680
90histone arginine methylation (GO:0034969)2.99348557
91* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98915318
92intra-S DNA damage checkpoint (GO:0031573)2.98343431
93postreplication repair (GO:0006301)2.97276071
94positive regulation of chromosome segregation (GO:0051984)2.96382327
95DNA damage response, detection of DNA damage (GO:0042769)2.96181922
96folic acid-containing compound biosynthetic process (GO:0009396)2.95066179
97* negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94719570
98* negative regulation of ligase activity (GO:0051352)2.94719570
99mismatch repair (GO:0006298)2.93661162
100regulation of DNA endoreduplication (GO:0032875)2.91997503
101histone exchange (GO:0043486)2.91135875
102regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89464176
103regulation of mitotic spindle checkpoint (GO:1903504)2.89464176
104paraxial mesoderm development (GO:0048339)2.89381595
105negative regulation of mRNA processing (GO:0050686)2.88887147
106regulation of mitochondrial translation (GO:0070129)2.87636918
107pore complex assembly (GO:0046931)2.86755860
108ATP-dependent chromatin remodeling (GO:0043044)2.86642112
109negative regulation of histone methylation (GO:0031061)2.86619442
110chromosome segregation (GO:0007059)2.85919832
111negative regulation of DNA-dependent DNA replication (GO:2000104)2.85889184
112regulation of double-strand break repair via homologous recombination (GO:0010569)2.85270758
113RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84748545
114mRNA splicing, via spliceosome (GO:0000398)2.84748545
115peptidyl-arginine N-methylation (GO:0035246)2.84625136
116peptidyl-arginine methylation (GO:0018216)2.84625136
117regulation of centrosome cycle (GO:0046605)2.83562104
118RNA splicing, via transesterification reactions (GO:0000375)2.83308161
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.83061426
120regulation of sister chromatid cohesion (GO:0007063)2.81835715
121ribosome biogenesis (GO:0042254)2.81241856
122DNA conformation change (GO:0071103)2.81142282
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.80855965
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80855965
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80855965
126regulation of centriole replication (GO:0046599)2.80824589
127spliceosomal snRNP assembly (GO:0000387)2.79357663
128dosage compensation (GO:0007549)2.77090548
129meiotic chromosome segregation (GO:0045132)2.76449407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.66922224
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.88897354
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21611132
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.07382176
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.38733128
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12779267
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91032895
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86076764
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84243528
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.83004475
11* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.82522177
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75847481
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.74390778
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49509405
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45972384
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40107789
17* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31210410
18* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.29899882
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.28727446
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.28092670
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24343308
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23404385
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21834628
24XRN2_22483619_ChIP-Seq_HELA_Human2.21287928
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20399190
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.17988954
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.17095926
28* E2F1_21310950_ChIP-Seq_MCF-7_Human2.15087028
29AR_21909140_ChIP-Seq_LNCAP_Human2.14168267
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.12631012
31* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07094007
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99727420
33CIITA_25753668_ChIP-Seq_RAJI_Human1.99015409
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93444183
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92253302
36VDR_23849224_ChIP-Seq_CD4+_Human1.88845147
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86587759
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84972319
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.84712980
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80672261
41FOXP3_21729870_ChIP-Seq_TREG_Human1.77766021
42TTF2_22483619_ChIP-Seq_HELA_Human1.75828301
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73111113
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70376364
45* ELK1_19687146_ChIP-ChIP_HELA_Human1.66137506
46* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63541043
47GABP_19822575_ChIP-Seq_HepG2_Human1.62748132
48* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60651396
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60566793
50DCP1A_22483619_ChIP-Seq_HELA_Human1.60403674
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55974856
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54263359
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52456507
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49510076
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45314450
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45304172
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43063219
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.41969970
59MYC_22102868_ChIP-Seq_BL_Human1.40647818
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39902351
61MYC_18940864_ChIP-ChIP_HL60_Human1.39137635
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37402184
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36480244
64KDM5A_27292631_Chip-Seq_BREAST_Human1.31634267
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.28432823
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27893203
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24492335
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21908403
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.21118000
70FUS_26573619_Chip-Seq_HEK293_Human1.19366702
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19150198
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18367343
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17820800
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.16220287
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.12237630
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12179121
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.11225694
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09640911
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09389267
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09007622
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08336798
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07975356
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06298635
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05643340
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04824618
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02497576
87ZNF274_21170338_ChIP-Seq_K562_Hela1.01528845
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00412615
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99088903
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98382055
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98379985
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98241661
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97597724
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97597724
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97597724
96TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97362304
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97215144
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95250632
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94981432
100TFEB_21752829_ChIP-Seq_HELA_Human0.94381624
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92848081
102KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92662300
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91571387
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86841498
105ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86484186
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86448221
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.84557629
108* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84091050
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81509626
110EWS_26573619_Chip-Seq_HEK293_Human0.80891762
111IRF1_19129219_ChIP-ChIP_H3396_Human0.80457768
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76315789
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.75850297
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72572289
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72571685
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.72224593
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69612413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.63336638
2MP0010094_abnormal_chromosome_stability3.60924354
3MP0003693_abnormal_embryo_hatching3.56779603
4MP0003123_paternal_imprinting3.56692627
5MP0003111_abnormal_nucleus_morphology3.39630945
6MP0004957_abnormal_blastocyst_morpholog3.27402192
7MP0003077_abnormal_cell_cycle3.26781126
8MP0008058_abnormal_DNA_repair2.99075594
9MP0003121_genomic_imprinting2.94472697
10MP0010030_abnormal_orbit_morphology2.75319777
11MP0008007_abnormal_cellular_replicative2.54455935
12MP0003122_maternal_imprinting2.40028530
13MP0008932_abnormal_embryonic_tissue2.22756852
14MP0001730_embryonic_growth_arrest2.02758443
15MP0002102_abnormal_ear_morphology1.89586135
16MP0003890_abnormal_embryonic-extraembry1.87024528
17MP0000350_abnormal_cell_proliferation1.86641647
18MP0003787_abnormal_imprinting1.86395829
19MP0003718_maternal_effect1.86126714
20MP0003806_abnormal_nucleotide_metabolis1.81606415
21MP0000537_abnormal_urethra_morphology1.78606614
22MP0001293_anophthalmia1.76900696
23MP0008877_abnormal_DNA_methylation1.71550679
24MP0001672_abnormal_embryogenesis/_devel1.71185647
25MP0005380_embryogenesis_phenotype1.71185647
26MP0002085_abnormal_embryonic_tissue1.69732330
27MP0001697_abnormal_embryo_size1.67950725
28MP0002084_abnormal_developmental_patter1.66302127
29MP0006292_abnormal_olfactory_placode1.66052124
30MP0003119_abnormal_digestive_system1.61989132
31MP0009053_abnormal_anal_canal1.61537761
32MP0004197_abnormal_fetal_growth/weight/1.60900223
33MP0003984_embryonic_growth_retardation1.57451010
34MP0010352_gastrointestinal_tract_polyps1.56933219
35MP0002088_abnormal_embryonic_growth/wei1.56245425
36MP0003567_abnormal_fetal_cardiomyocyte1.55132877
37MP0002938_white_spotting1.50990683
38MP0002396_abnormal_hematopoietic_system1.49042872
39MP0002080_prenatal_lethality1.40875350
40MP0003942_abnormal_urinary_system1.39638818
41MP0003221_abnormal_cardiomyocyte_apopto1.38855693
42MP0004133_heterotaxia1.37763754
43MP0003941_abnormal_skin_development1.36820128
44MP0001529_abnormal_vocalization1.34421990
45MP0003937_abnormal_limbs/digits/tail_de1.33693109
46MP0002086_abnormal_extraembryonic_tissu1.33007540
47MP0003315_abnormal_perineum_morphology1.31421806
48MP0004147_increased_porphyrin_level1.30778450
49MP0006035_abnormal_mitochondrial_morpho1.30411845
50MP0002653_abnormal_ependyma_morphology1.27905700
51MP0006054_spinal_hemorrhage1.27057679
52MP0005367_renal/urinary_system_phenotyp1.26130347
53MP0000516_abnormal_urinary_system1.26130347
54MP0000358_abnormal_cell_content/1.25564446
55MP0000049_abnormal_middle_ear1.25125032
56MP0004808_abnormal_hematopoietic_stem1.23400615
57MP0008995_early_reproductive_senescence1.22961006
58MP0003786_premature_aging1.20912700
59MP0003385_abnormal_body_wall1.19269633
60MP0000566_synostosis1.19185596
61MP0000428_abnormal_craniofacial_morphol1.17318199
62MP0003115_abnormal_respiratory_system1.14585218
63MP0010234_abnormal_vibrissa_follicle1.11240223
64MP0003935_abnormal_craniofacial_develop1.11205412
65MP0003186_abnormal_redox_activity1.09866963
66MP0010307_abnormal_tumor_latency1.09744798
67MP0003283_abnormal_digestive_organ1.09510831
68MP0001661_extended_life_span1.06961143
69MP0001286_abnormal_eye_development1.06679451
70MP0005076_abnormal_cell_differentiation1.06182591
71MP0002111_abnormal_tail_morphology1.05146873
72MP0000313_abnormal_cell_death1.05090781
73MP0001929_abnormal_gametogenesis1.04277947
74MP0000569_abnormal_digit_pigmentation1.04135709
75MP0002234_abnormal_pharynx_morphology1.03937937
76MP0002249_abnormal_larynx_morphology1.03726182
77MP0002932_abnormal_joint_morphology1.03612379
78MP0009703_decreased_birth_body1.01441681
79MP0009672_abnormal_birth_weight1.00382905
80MP0003755_abnormal_palate_morphology0.99479569
81MP0006036_abnormal_mitochondrial_physio0.98313456
82MP0002009_preneoplasia0.96590001
83MP0002751_abnormal_autonomic_nervous0.95022794
84MP0005187_abnormal_penis_morphology0.94816914
85MP0003861_abnormal_nervous_system0.94550882
86MP0002114_abnormal_axial_skeleton0.94543956
87MP0002116_abnormal_craniofacial_bone0.93564759
88MP0000534_abnormal_ureter_morphology0.91972233
89MP0000372_irregular_coat_pigmentation0.89672138
90MP0000647_abnormal_sebaceous_gland0.89420094
91MP0000490_abnormal_crypts_of0.89207801
92MP0004264_abnormal_extraembryonic_tissu0.88382483
93MP0000653_abnormal_sex_gland0.88166794
94MP0004084_abnormal_cardiac_muscle0.88063776
95MP0002210_abnormal_sex_determination0.87312916
96MP0004233_abnormal_muscle_weight0.86539866
97MP0002127_abnormal_cardiovascular_syste0.85290397
98MP0001727_abnormal_embryo_implantation0.84734677
99MP0000432_abnormal_head_morphology0.83837238
100MP0009250_abnormal_appendicular_skeleto0.82494652
101MP0010678_abnormal_skin_adnexa0.82166652
102MP0002697_abnormal_eye_size0.81390781
103MP0001119_abnormal_female_reproductive0.80141800
104MP0001764_abnormal_homeostasis0.78542106
105MP0008789_abnormal_olfactory_epithelium0.78535340
106MP0001299_abnormal_eye_distance/0.78228432
107MP0002092_abnormal_eye_morphology0.77424434
108MP0005499_abnormal_olfactory_system0.76301327
109MP0005394_taste/olfaction_phenotype0.76301327
110MP0001346_abnormal_lacrimal_gland0.75834913
111MP0000678_abnormal_parathyroid_gland0.75730553
112MP0002090_abnormal_vision0.75630362
113MP0002925_abnormal_cardiovascular_devel0.75423708
114MP0005248_abnormal_Harderian_gland0.73771807
115MP0005084_abnormal_gallbladder_morpholo0.73608866
116MP0005408_hypopigmentation0.73550570
117MP0001145_abnormal_male_reproductive0.73457230
118MP0002282_abnormal_trachea_morphology0.73003492
119MP0002109_abnormal_limb_morphology0.72841212
120MP0005391_vision/eye_phenotype0.72708658
121MP0005384_cellular_phenotype0.72171049
122MP0002233_abnormal_nose_morphology0.71633847
123MP0002160_abnormal_reproductive_system0.71193310
124MP0000383_abnormal_hair_follicle0.70072744
125MP0002081_perinatal_lethality0.69722386
126MP0001915_intracranial_hemorrhage0.69087450
127MP0000631_abnormal_neuroendocrine_gland0.69067392
128MP0006072_abnormal_retinal_apoptosis0.68788253
129MP0003943_abnormal_hepatobiliary_system0.68424800
130MP0009697_abnormal_copulation0.67727284
131MP0002019_abnormal_tumor_incidence0.67166179
132MP0001849_ear_inflammation0.67075647
133MP0005508_abnormal_skeleton_morphology0.66112447
134MP0000266_abnormal_heart_morphology0.65790058
135MP0001177_atelectasis0.64495611
136MP0003698_abnormal_male_reproductive0.60942782

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.51143036
2Medulloblastoma (HP:0002885)3.47021445
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.27446224
4Short 4th metacarpal (HP:0010044)3.27446224
5Ependymoma (HP:0002888)3.24043549
6Birth length less than 3rd percentile (HP:0003561)3.16142055
7Patellar aplasia (HP:0006443)2.99454386
8Selective tooth agenesis (HP:0001592)2.84999286
9Abnormality of glycolysis (HP:0004366)2.83882498
10Aplasia/Hypoplasia of the patella (HP:0006498)2.79067828
11Abnormality of methionine metabolism (HP:0010901)2.77382787
12Abnormality of the labia minora (HP:0012880)2.76781805
13Abnormal number of incisors (HP:0011064)2.76377943
14Increased serum pyruvate (HP:0003542)2.75275409
15Microvesicular hepatic steatosis (HP:0001414)2.68375293
16Chromsome breakage (HP:0040012)2.66772213
17Increased nuchal translucency (HP:0010880)2.65325220
18Abnormal lung lobation (HP:0002101)2.63466991
19Nephroblastoma (Wilms tumor) (HP:0002667)2.63147969
20Renal duplication (HP:0000075)2.61534563
21Meckel diverticulum (HP:0002245)2.60444985
22Volvulus (HP:0002580)2.59073405
23Cortical dysplasia (HP:0002539)2.56104513
24Embryonal renal neoplasm (HP:0011794)2.55348495
25Abnormality of the ileum (HP:0001549)2.55059653
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51613571
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.47778667
28Abnormality of the astrocytes (HP:0100707)2.43257756
29Astrocytoma (HP:0009592)2.43257756
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.41839615
31Multiple enchondromatosis (HP:0005701)2.39230942
32Duodenal stenosis (HP:0100867)2.37237651
33Small intestinal stenosis (HP:0012848)2.37237651
34Methylmalonic acidemia (HP:0002912)2.37080209
35Abnormal umbilical cord blood vessels (HP:0011403)2.35614082
36Single umbilical artery (HP:0001195)2.35614082
37Abnormality of the fetal cardiovascular system (HP:0010948)2.35614082
38Deviation of the thumb (HP:0009603)2.33788813
39Proximal placement of thumb (HP:0009623)2.32296330
40Supernumerary spleens (HP:0009799)2.30934909
41Triphalangeal thumb (HP:0001199)2.29654286
42Abnormality of the anterior horn cell (HP:0006802)2.29070949
43Degeneration of anterior horn cells (HP:0002398)2.29070949
44Abnormality of the 4th metacarpal (HP:0010012)2.29057086
45Abnormality of chromosome stability (HP:0003220)2.28983878
46Glioma (HP:0009733)2.26845394
47Neoplasm of the oral cavity (HP:0100649)2.26113505
48Ectopic kidney (HP:0000086)2.23245157
49Breast hypoplasia (HP:0003187)2.18725303
50Increased hepatocellular lipid droplets (HP:0006565)2.14111426
51Atresia of the external auditory canal (HP:0000413)2.13441956
52Short 5th finger (HP:0009237)2.11589388
53Clubbing of toes (HP:0100760)2.09099300
54Agnosia (HP:0010524)2.09045138
55Gonadotropin excess (HP:0000837)2.08586998
56Hyperglycinemia (HP:0002154)2.08419193
57Diastasis recti (HP:0001540)2.06809816
58Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.05438157
59Abnormality of the duodenum (HP:0002246)2.04377746
60Tubulointerstitial nephritis (HP:0001970)2.04090715
61Hepatoblastoma (HP:0002884)2.03409940
62Hypoplastic pelvis (HP:0008839)2.01612482
63Abnormality of the preputium (HP:0100587)2.01174980
64Myelodysplasia (HP:0002863)2.01046915
65Short middle phalanx of the 5th finger (HP:0004220)1.99890381
66Impulsivity (HP:0100710)1.98864497
67Horseshoe kidney (HP:0000085)1.98630718
68Broad palm (HP:0001169)1.98320404
69Absent radius (HP:0003974)1.98191700
70Broad alveolar ridges (HP:0000187)1.97574970
71Shoulder girdle muscle weakness (HP:0003547)1.97301157
72Abnormality of the umbilical cord (HP:0010881)1.97258256
73Rhabdomyosarcoma (HP:0002859)1.96920227
74Bifid tongue (HP:0010297)1.96594652
75Lipid accumulation in hepatocytes (HP:0006561)1.95239822
76Abnormality of abdominal situs (HP:0011620)1.94920224
77Abdominal situs inversus (HP:0003363)1.94920224
78Aplasia involving forearm bones (HP:0009822)1.94606665
79Absent forearm bone (HP:0003953)1.94606665
80Carpal bone hypoplasia (HP:0001498)1.94370165
81Missing ribs (HP:0000921)1.94216417
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93847433
83Oral leukoplakia (HP:0002745)1.89225104
84Neoplasm of the adrenal gland (HP:0100631)1.89179027
85Choanal atresia (HP:0000453)1.88762134
86Anophthalmia (HP:0000528)1.86195678
87Secondary amenorrhea (HP:0000869)1.84282517
88Increased CSF lactate (HP:0002490)1.83875796
89Neoplasm of the pancreas (HP:0002894)1.83437859
90Sloping forehead (HP:0000340)1.82817491
91Premature graying of hair (HP:0002216)1.82676296
92Broad thumb (HP:0011304)1.82483157
93Skull defect (HP:0001362)1.81754722
94Intestinal atresia (HP:0011100)1.81293204
95Aplastic anemia (HP:0001915)1.81174341
96Acute encephalopathy (HP:0006846)1.80679854
97Abnormality of the carotid arteries (HP:0005344)1.80175330
98Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80135904
99Mesomelia (HP:0003027)1.80097340
100Increased serum lactate (HP:0002151)1.79736866
101Methylmalonic aciduria (HP:0012120)1.79400344
102Long eyelashes (HP:0000527)1.79400127
103Postnatal microcephaly (HP:0005484)1.79398359
104Abnormal gallbladder physiology (HP:0012438)1.78790440
105Cholecystitis (HP:0001082)1.78790440
10611 pairs of ribs (HP:0000878)1.78766565
107Embryonal neoplasm (HP:0002898)1.78346617
108Broad phalanges of the hand (HP:0009768)1.78239198
109Hepatocellular necrosis (HP:0001404)1.77738270
110Abnormal mitochondria in muscle tissue (HP:0008316)1.76861087
111Ovarian neoplasm (HP:0100615)1.75992428
112Neoplasm of striated muscle (HP:0009728)1.74479903
113Optic nerve coloboma (HP:0000588)1.74106938
114Tracheoesophageal fistula (HP:0002575)1.73633376
115Trigonocephaly (HP:0000243)1.73157323
116Broad finger (HP:0001500)1.72508627
117Abnormality of serum amino acid levels (HP:0003112)1.72463222
118High anterior hairline (HP:0009890)1.72188061
119Spastic diplegia (HP:0001264)1.72072191
120Facial cleft (HP:0002006)1.71418183
121Arteriovenous malformation (HP:0100026)1.71254670
122Deep philtrum (HP:0002002)1.67924544
123Neoplasm of the colon (HP:0100273)1.67105741
124Atrophy/Degeneration involving motor neurons (HP:0007373)1.66722497
125Reticulocytopenia (HP:0001896)1.66305061
126Acute necrotizing encephalopathy (HP:0006965)1.66083515
127Abnormalities of placenta or umbilical cord (HP:0001194)1.65760375
128Facial hemangioma (HP:0000329)1.65416036
129Hepatic necrosis (HP:0002605)1.63434818
130Rib fusion (HP:0000902)1.63156052
131Basal cell carcinoma (HP:0002671)1.62980130
132Pancreatic islet-cell hyperplasia (HP:0004510)1.62696533
133Abnormality of the incisor (HP:0000676)1.62302310
134Type I transferrin isoform profile (HP:0003642)1.61788823
135Amaurosis fugax (HP:0100576)1.61476102
136Cafe-au-lait spot (HP:0000957)1.60812431
137Megaloblastic anemia (HP:0001889)1.60379168
138Aplasia/hypoplasia of the humerus (HP:0006507)1.59815543
139Anal stenosis (HP:0002025)1.59810665
140Skin tags (HP:0010609)1.59715444
141Preauricular skin tag (HP:0000384)1.59630679
142Absent thumb (HP:0009777)1.59060884
143Bone marrow hypocellularity (HP:0005528)1.58844648
144Benign neoplasm of the central nervous system (HP:0100835)1.58833513
145Stenosis of the external auditory canal (HP:0000402)1.58759831
146Preaxial hand polydactyly (HP:0001177)1.57395432
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.56909140
148Abnormal protein N-linked glycosylation (HP:0012347)1.56909140
149Abnormal protein glycosylation (HP:0012346)1.56909140
150Abnormal glycosylation (HP:0012345)1.56909140
151Hypoplastic labia majora (HP:0000059)1.56885260
152Overlapping toe (HP:0001845)1.56854989
153Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.55948174
154Mitochondrial inheritance (HP:0001427)1.53558692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.19494295
2CDC74.07035924
3WEE13.73088355
4TSSK63.05915586
5SRPK12.94525178
6MKNK12.86378318
7PASK2.74185600
8NEK12.44669522
9PBK2.40115258
10NEK22.38338960
11BRSK22.38284127
12PLK32.30445615
13TRIM282.27233554
14CDK122.26016711
15TTK2.17766277
16EIF2AK12.16922173
17VRK22.10041533
18BRSK12.06241504
19CCNB12.01462097
20* PLK11.95007696
21ATR1.94632283
22TGFBR11.93414309
23MKNK21.92059461
24MST41.90558426
25ACVR1B1.77616567
26BRD41.70507495
27PLK41.67999616
28VRK11.66763372
29MAP4K21.66287773
30CDK71.61940604
31AURKB1.54071250
32CHEK21.53499899
33AKT31.52266347
34RPS6KB21.44895644
35TAF11.39762651
36DYRK31.37634509
37CHEK11.35700618
38SIK31.29227474
39ERBB31.25487171
40ZAK1.24840612
41PDK21.22547802
42PAK41.15961354
43AURKA1.12580442
44STK161.11440828
45EEF2K1.09613836
46ATM1.06214591
47EIF2AK31.03242568
48CDK21.00928882
49STK100.98183172
50CDK40.96090039
51CDK80.94944839
52TAOK20.94080841
53MELK0.91045415
54FGFR10.88185681
55MAP3K80.87671134
56* CDK10.86631326
57MAPK130.85008465
58EPHA20.84648783
59EIF2AK20.81175526
60RPS6KA40.79497671
61NME10.78286625
62MAP3K100.76843125
63ERBB40.75617562
64STK40.75571006
65CSNK1G10.71443109
66STK38L0.70225885
67BCR0.69011116
68DYRK20.67961156
69YES10.67456761
70LATS10.67298293
71SCYL20.67289658
72MAP3K120.66068874
73NEK90.65492477
74CSNK1G30.64430691
75TLK10.62362524
76BMPR1B0.61879610
77CSNK2A10.59079959
78CSNK2A20.57840514
79TNIK0.57713736
80NME20.56722150
81TESK20.56431444
82STK30.56260172
83PLK20.55078382
84ALK0.53420962
85MAP3K40.52900974
86MTOR0.52838751
87AKT20.51845902
88PRKDC0.51287494
89MAP2K70.50792375
90CSNK1A1L0.50686212
91PRKCI0.50332561
92KSR10.49852296
93CSNK1G20.49212285
94LATS20.49026527
95PKN20.47380677
96BCKDK0.46734624
97MAPK140.46362491
98NUAK10.44059583
99PIM10.41969167
100CDK60.41862592
101CDK90.41504616
102CDK30.39275751
103UHMK10.39093968
104GSK3B0.38603469
105AKT10.37938648
106PAK10.36460465
107TESK10.36328199
108CSNK1E0.35928785
109RPS6KB10.35644106
110PDK30.35089674
111PDK40.35089674
112WNK30.34686538
113CLK10.34408862
114STK240.33936628
115MAPKAPK50.33691362
116CDC42BPA0.31558516
117DAPK10.31263181
118BRAF0.31076436
119LIMK10.30313376
120CSNK1D0.30035687
121MAPK90.29741699
122PNCK0.28188254
123MAPK10.27999327
124FLT30.27886214
125CDK150.26743179
126MINK10.26492835
127CDK140.26356382
128MUSK0.26189256
129CDK180.26047158
130CDK11A0.24851588

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44941435
2Mismatch repair_Homo sapiens_hsa034304.34036048
3Spliceosome_Homo sapiens_hsa030403.40571786
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17968448
5* Cell cycle_Homo sapiens_hsa041103.16517098
6RNA transport_Homo sapiens_hsa030133.15714952
7Base excision repair_Homo sapiens_hsa034103.10241618
8Nucleotide excision repair_Homo sapiens_hsa034202.95401891
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.85813574
10Homologous recombination_Homo sapiens_hsa034402.81360879
11One carbon pool by folate_Homo sapiens_hsa006702.56643743
12Fanconi anemia pathway_Homo sapiens_hsa034602.41121695
13RNA polymerase_Homo sapiens_hsa030202.41121265
14Non-homologous end-joining_Homo sapiens_hsa034502.26991094
15Proteasome_Homo sapiens_hsa030502.24340335
16mRNA surveillance pathway_Homo sapiens_hsa030152.24105390
17RNA degradation_Homo sapiens_hsa030182.13215790
18Fatty acid elongation_Homo sapiens_hsa000621.88165105
19Propanoate metabolism_Homo sapiens_hsa006401.85704773
20Basal transcription factors_Homo sapiens_hsa030221.85411226
21Pyrimidine metabolism_Homo sapiens_hsa002401.77523667
22Ribosome_Homo sapiens_hsa030101.63129943
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61309444
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57830296
25p53 signaling pathway_Homo sapiens_hsa041151.55233052
26Steroid biosynthesis_Homo sapiens_hsa001001.54850161
27* Oocyte meiosis_Homo sapiens_hsa041141.47514460
28Pyruvate metabolism_Homo sapiens_hsa006201.47201566
29* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46519566
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38157686
31Basal cell carcinoma_Homo sapiens_hsa052171.31613902
32* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27460082
33Vitamin B6 metabolism_Homo sapiens_hsa007501.25629929
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22970830
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21077679
36Hippo signaling pathway_Homo sapiens_hsa043901.16435060
37Purine metabolism_Homo sapiens_hsa002301.12601363
38Epstein-Barr virus infection_Homo sapiens_hsa051691.11536857
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10595161
40Viral carcinogenesis_Homo sapiens_hsa052031.08816690
41Systemic lupus erythematosus_Homo sapiens_hsa053221.07087480
42Hedgehog signaling pathway_Homo sapiens_hsa043401.05396322
43MicroRNAs in cancer_Homo sapiens_hsa052061.02615188
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01348046
45Colorectal cancer_Homo sapiens_hsa052100.99515594
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98660579
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94986122
48Parkinsons disease_Homo sapiens_hsa050120.93714229
49* HTLV-I infection_Homo sapiens_hsa051660.93271377
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89804470
51TGF-beta signaling pathway_Homo sapiens_hsa043500.89533742
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87877314
53Fatty acid metabolism_Homo sapiens_hsa012120.87018778
54Alcoholism_Homo sapiens_hsa050340.83402709
55Notch signaling pathway_Homo sapiens_hsa043300.81896130
56Oxidative phosphorylation_Homo sapiens_hsa001900.81574667
57Wnt signaling pathway_Homo sapiens_hsa043100.78842399
58Pentose phosphate pathway_Homo sapiens_hsa000300.77831713
59Folate biosynthesis_Homo sapiens_hsa007900.77115210
60Adherens junction_Homo sapiens_hsa045200.75854099
61Herpes simplex infection_Homo sapiens_hsa051680.75243464
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74883061
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74113578
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72900922
65N-Glycan biosynthesis_Homo sapiens_hsa005100.71382495
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70168931
67Thyroid cancer_Homo sapiens_hsa052160.68112722
68Glutathione metabolism_Homo sapiens_hsa004800.66112815
69Butanoate metabolism_Homo sapiens_hsa006500.62724419
70Biosynthesis of amino acids_Homo sapiens_hsa012300.62002003
71Small cell lung cancer_Homo sapiens_hsa052220.60572621
72Antigen processing and presentation_Homo sapiens_hsa046120.58443276
73Metabolic pathways_Homo sapiens_hsa011000.56203323
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55709695
75Pathways in cancer_Homo sapiens_hsa052000.55278982
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51739505
77Viral myocarditis_Homo sapiens_hsa054160.51571515
78Selenocompound metabolism_Homo sapiens_hsa004500.50297771
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.49876361
80mTOR signaling pathway_Homo sapiens_hsa041500.49672707
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46909028
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45656822
83Endometrial cancer_Homo sapiens_hsa052130.45024226
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44610594
85Tight junction_Homo sapiens_hsa045300.44291292
86Arginine and proline metabolism_Homo sapiens_hsa003300.43455408
87Fatty acid degradation_Homo sapiens_hsa000710.42456641
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42037082
89HIF-1 signaling pathway_Homo sapiens_hsa040660.42017231
90Prostate cancer_Homo sapiens_hsa052150.40063297
91Chronic myeloid leukemia_Homo sapiens_hsa052200.39454952
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38812810
93Melanoma_Homo sapiens_hsa052180.38703286
94Proteoglycans in cancer_Homo sapiens_hsa052050.37428118
95Protein export_Homo sapiens_hsa030600.36141269
96Peroxisome_Homo sapiens_hsa041460.35940309
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34470943
98Hepatitis B_Homo sapiens_hsa051610.32643309
99Lysine degradation_Homo sapiens_hsa003100.32528517
100Alzheimers disease_Homo sapiens_hsa050100.31504995
101Sulfur relay system_Homo sapiens_hsa041220.30438083
102Legionellosis_Homo sapiens_hsa051340.29851883
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.29229721
104Arginine biosynthesis_Homo sapiens_hsa002200.28981054
105Focal adhesion_Homo sapiens_hsa045100.28799300
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28394513
107Galactose metabolism_Homo sapiens_hsa000520.27741314
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27650518
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27219304
110Tryptophan metabolism_Homo sapiens_hsa003800.26170176
111Bladder cancer_Homo sapiens_hsa052190.24307009
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23691593
113Carbon metabolism_Homo sapiens_hsa012000.23557758
114Melanogenesis_Homo sapiens_hsa049160.23318235
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.21917756
116beta-Alanine metabolism_Homo sapiens_hsa004100.21256569
117Vitamin digestion and absorption_Homo sapiens_hsa049770.21247827
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21241213
119Axon guidance_Homo sapiens_hsa043600.21234848
120Primary immunodeficiency_Homo sapiens_hsa053400.21171839
121FoxO signaling pathway_Homo sapiens_hsa040680.20776852
122Dilated cardiomyopathy_Homo sapiens_hsa054140.20695421
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20571338
124Non-small cell lung cancer_Homo sapiens_hsa052230.19798845
125Pancreatic cancer_Homo sapiens_hsa052120.19357362
126ECM-receptor interaction_Homo sapiens_hsa045120.19349214
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19082595
128Sulfur metabolism_Homo sapiens_hsa009200.18250542
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.17434008
130Huntingtons disease_Homo sapiens_hsa050160.17121237
131Gap junction_Homo sapiens_hsa045400.16443791
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.14471693
133Apoptosis_Homo sapiens_hsa042100.14077467
134Fructose and mannose metabolism_Homo sapiens_hsa000510.13582180
135Measles_Homo sapiens_hsa051620.13270056
136Glioma_Homo sapiens_hsa052140.13145914
137Phototransduction_Homo sapiens_hsa047440.12415845
138Shigellosis_Homo sapiens_hsa051310.12098789
139Glucagon signaling pathway_Homo sapiens_hsa049220.11003975
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.09916823
141Caffeine metabolism_Homo sapiens_hsa002320.08055790
142Nitrogen metabolism_Homo sapiens_hsa009100.06725824
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05963627

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