CD99

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of extracellular matrix disassembly (GO:0010715)3.88951479
2protein maturation by protein folding (GO:0022417)3.78335726
3keratan sulfate catabolic process (GO:0042340)3.63396297
4positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.45637793
5regulation of type B pancreatic cell apoptotic process (GO:2000674)3.35331907
6regulation of integrin-mediated signaling pathway (GO:2001044)3.34001644
7reverse cholesterol transport (GO:0043691)3.20267710
8peptide hormone processing (GO:0016486)3.12307882
9negative regulation of nitric oxide biosynthetic process (GO:0045019)2.97250478
10high-density lipoprotein particle remodeling (GO:0034375)2.93953091
11adhesion of symbiont to host (GO:0044406)2.86345105
12extracellular fibril organization (GO:0043206)2.78636481
13positive regulation of calcium ion import (GO:0090280)2.76260521
14epithelial cell fate commitment (GO:0072148)2.75636026
15regulation of cholesterol esterification (GO:0010872)2.75318381
16fibril organization (GO:0097435)2.71743788
17angiogenesis involved in wound healing (GO:0060055)2.68467938
18regulation of B cell apoptotic process (GO:0002902)2.66184176
19xenobiotic catabolic process (GO:0042178)2.64828085
20endothelium development (GO:0003158)2.63651181
21regulation of metalloenzyme activity (GO:0048552)2.58369959
22regulation of gonadotropin secretion (GO:0032276)2.57518197
23negative regulation of execution phase of apoptosis (GO:1900118)2.43898870
24regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.43377307
25eosinophil chemotaxis (GO:0048245)2.42041162
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42019425
27peptidyl-glutamic acid carboxylation (GO:0017187)2.41453563
28protein carboxylation (GO:0018214)2.41453563
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.40454692
30venous blood vessel morphogenesis (GO:0048845)2.38688755
31platelet dense granule organization (GO:0060155)2.37538998
32cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.37118460
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.35839507
34blood vessel maturation (GO:0001955)2.34423794
35virion attachment to host cell (GO:0019062)2.34324098
36adhesion of symbiont to host cell (GO:0044650)2.34324098
37barbed-end actin filament capping (GO:0051016)2.33143236
38autophagic vacuole fusion (GO:0000046)2.32859122
39regulation of execution phase of apoptosis (GO:1900117)2.31341949
40L-phenylalanine catabolic process (GO:0006559)2.30163166
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.30163166
42regulation of extracellular matrix organization (GO:1903053)2.29197307
43negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.28612964
44antigen processing and presentation of endogenous antigen (GO:0019883)2.28042240
45amyloid precursor protein catabolic process (GO:0042987)2.27432763
46regulation of autophagic vacuole assembly (GO:2000785)2.26876531
47regulation of collagen metabolic process (GO:0010712)2.26595346
48negative regulation of nitric-oxide synthase activity (GO:0051001)2.26537631
49oligosaccharide catabolic process (GO:0009313)2.26318466
50platelet degranulation (GO:0002576)2.24402964
51L-ascorbic acid metabolic process (GO:0019852)2.23872272
52positive regulation of actin filament depolymerization (GO:0030836)2.22615570
53protein heterotrimerization (GO:0070208)2.22585832
54sequestering of extracellular ligand from receptor (GO:0035581)2.22118327
55astrocyte differentiation (GO:0048708)2.21770063
56hemoglobin metabolic process (GO:0020027)2.21590081
57negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.21311451
58antigen processing and presentation via MHC class Ib (GO:0002475)2.20919152
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.20293023
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.20006216
61glycerophospholipid catabolic process (GO:0046475)2.19708574
62endosome to melanosome transport (GO:0035646)2.19519869
63endosome to pigment granule transport (GO:0043485)2.19519869
64type B pancreatic cell proliferation (GO:0044342)2.19441246
65negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.18779258
66eosinophil migration (GO:0072677)2.18446172
67lytic vacuole organization (GO:0080171)2.17610445
68lysosome organization (GO:0007040)2.17610445
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.17381569
70L-phenylalanine metabolic process (GO:0006558)2.17381569
71hydrogen peroxide catabolic process (GO:0042744)2.16008628
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.15451685
73amino sugar catabolic process (GO:0046348)2.15272839
74endothelial cell proliferation (GO:0001935)2.13941753
75response to gravity (GO:0009629)2.12978206
76vasodilation (GO:0042311)2.11744984
77regulation of vacuole organization (GO:0044088)2.09959580
78nitric oxide biosynthetic process (GO:0006809)2.09216238
79organelle membrane fusion (GO:0090174)2.07947059
80macroautophagy (GO:0016236)2.07866065
81skin morphogenesis (GO:0043589)2.05967325
82peptide catabolic process (GO:0043171)2.05246898
83cell migration involved in heart development (GO:0060973)2.04296459
84purine nucleotide salvage (GO:0032261)2.03564420
85negative regulation of tissue remodeling (GO:0034104)2.02571237
86nitric oxide mediated signal transduction (GO:0007263)2.02555182
87negative regulation of glycoprotein metabolic process (GO:1903019)2.02522684
88immunoglobulin mediated immune response (GO:0016064)2.02330385
89Golgi transport vesicle coating (GO:0048200)2.01217847
90COPI coating of Golgi vesicle (GO:0048205)2.01217847
91regulation of multicellular organismal metabolic process (GO:0044246)2.00705346
92cellular zinc ion homeostasis (GO:0006882)2.00121413
93zinc ion homeostasis (GO:0055069)1.99383322
94protein-lipid complex remodeling (GO:0034368)1.99013976
95macromolecular complex remodeling (GO:0034367)1.99013976
96plasma lipoprotein particle remodeling (GO:0034369)1.99013976
97glucosamine-containing compound catabolic process (GO:1901072)1.96922315
98hyaluronan catabolic process (GO:0030214)1.96232746
99regulation of mononuclear cell migration (GO:0071675)1.96122229
100negative regulation of thymocyte apoptotic process (GO:0070244)1.95685674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.17215149
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.79792505
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.27721633
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.75152045
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.50772902
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42993435
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.34030308
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31406828
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24544050
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21151386
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15130773
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.14668867
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10465363
14RXR_22158963_ChIP-Seq_LIVER_Mouse1.97015466
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.95049202
16IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94564521
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90257611
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.88480109
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87794444
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85360116
21GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.73736923
22MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62586296
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61108560
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59444811
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.56446466
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.55766751
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.54160350
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53092063
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51835292
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.50464520
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49674756
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.47992024
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.45706001
34* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45705147
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37915221
36ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.33627449
37RUNX_20019798_ChIP-Seq_JUKART_Human1.30495865
38* SPI1_23127762_ChIP-Seq_K562_Human1.28072559
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27782774
40* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23611204
41* SOX2_20726797_ChIP-Seq_SW620_Human1.23353839
42VDR_24763502_ChIP-Seq_THP-1_Human1.22319023
43LXR_22292898_ChIP-Seq_THP-1_Human1.19769587
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18010631
45* CJUN_26792858_Chip-Seq_BT549_Human1.17502262
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.16651106
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16086146
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13853109
49* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13613477
50GATA1_19941826_ChIP-Seq_K562_Human1.13563867
51RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13262336
52BRD4_25478319_ChIP-Seq_HGPS_Human1.12762200
53VDR_24787735_ChIP-Seq_THP-1_Human1.09931516
54SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07475613
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07311482
56SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06776817
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06596999
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04500501
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02092188
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00288045
61ELF1_20517297_ChIP-Seq_JURKAT_Human0.99717129
62RUNX1_22412390_ChIP-Seq_EML_Mouse0.99054386
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98799922
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97553432
65EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96746494
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96028022
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94808569
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92815117
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91693417
70HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90761259
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90296802
72CLOCK_20551151_ChIP-Seq_293T_Human0.90106147
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89713692
74WT1_19549856_ChIP-ChIP_CCG9911_Human0.88432720
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87151287
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85121700
77GATA2_19941826_ChIP-Seq_K562_Human0.84522284
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83852732
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83543795
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83543795
81TBX20_22328084_ChIP-Seq_HEART_Mouse0.83431367
82TBX20_22080862_ChIP-Seq_HEART_Mouse0.83431367
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82778298
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.82237830
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.82042866
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81071323
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80192917
88BCL6_27268052_Chip-Seq_Bcells_Human0.79983371
89STAT1_20625510_ChIP-Seq_HELA_Human0.79722034
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79546359
91BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78158529
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78157648
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76995240
94UTX_26944678_Chip-Seq_JUKART_Human0.76272055
95P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74956074
96HTT_18923047_ChIP-ChIP_STHdh_Human0.74915929
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.74853582
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74650749
99* GATA3_27048872_Chip-Seq_THYMUS_Human0.74644839
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74228023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.24658111
2MP0005058_abnormal_lysosome_morphology3.57419401
3MP0009840_abnormal_foam_cell3.18986201
4MP0006054_spinal_hemorrhage3.02336625
5MP0003279_aneurysm2.84666610
6MP0005464_abnormal_platelet_physiology2.69926312
7MP0009780_abnormal_chondrocyte_physiolo2.56785170
8MP0003283_abnormal_digestive_organ2.52071490
9MP0000013_abnormal_adipose_tissue2.44128277
10MP0003172_abnormal_lysosome_physiology2.33208246
11MP0002837_dystrophic_cardiac_calcinosis2.24994603
12MP0005503_abnormal_tendon_morphology2.02458449
13MP0001958_emphysema2.01862578
14MP0008004_abnormal_stomach_pH1.96997554
15MP0002139_abnormal_hepatobiliary_system1.93970551
16MP0004272_abnormal_basement_membrane1.92687257
17MP0001542_abnormal_bone_strength1.89085956
18MP0010329_abnormal_lipoprotein_level1.85786717
19MP0010368_abnormal_lymphatic_system1.83983335
20MP0005379_endocrine/exocrine_gland_phen1.83829673
21MP0003300_gastrointestinal_ulcer1.75105489
22MP0003724_increased_susceptibility_to1.70663367
23MP0001835_abnormal_antigen_presentation1.69470100
24MP0002909_abnormal_adrenal_gland1.68673668
25MP0006082_CNS_inflammation1.64259135
26MP0003075_altered_response_to1.63602262
27MP0005257_abnormal_intraocular_pressure1.59465351
28MP0002933_joint_inflammation1.59252546
29MP0003436_decreased_susceptibility_to1.57527808
30MP0004510_myositis1.57278365
31MP0005275_abnormal_skin_tensile1.56736349
32MP0001533_abnormal_skeleton_physiology1.55702406
33MP0002876_abnormal_thyroid_physiology1.51114788
34MP0005365_abnormal_bile_salt1.44613005
35MP0002693_abnormal_pancreas_physiology1.42470282
36MP0002295_abnormal_pulmonary_circulatio1.42094410
37MP0000685_abnormal_immune_system1.38947806
38MP0002148_abnormal_hypersensitivity_rea1.38839228
39MP0001944_abnormal_pancreas_morphology1.37461069
40MP0005084_abnormal_gallbladder_morpholo1.35779287
41MP0003195_calcinosis1.35097875
42MP0009384_cardiac_valve_regurgitation1.32846122
43MP0003191_abnormal_cellular_cholesterol1.31412736
44MP0005390_skeleton_phenotype1.30848644
45MP0000343_altered_response_to1.27796136
46MP0000604_amyloidosis1.27562825
47MP0005023_abnormal_wound_healing1.25913509
48MP0002254_reproductive_system_inflammat1.22561725
49MP0005508_abnormal_skeleton_morphology1.21970421
50MP0004019_abnormal_vitamin_homeostasis1.21647766
51MP0002998_abnormal_bone_remodeling1.20180485
52MP0001756_abnormal_urination1.17433448
53MP0002163_abnormal_gland_morphology1.16228732
54MP0005165_increased_susceptibility_to1.13602061
55MP0000003_abnormal_adipose_tissue1.12760250
56MP0003303_peritoneal_inflammation1.11089470
57MP0001243_abnormal_dermal_layer1.10308776
58MP0002419_abnormal_innate_immunity1.09460666
59MP0005000_abnormal_immune_tolerance1.08201537
60MP0009785_altered_susceptibility_to1.06859173
61MP0005671_abnormal_response_to1.06341233
62MP0005595_abnormal_vascular_smooth1.03225998
63MP0003186_abnormal_redox_activity1.02562540
64MP0005164_abnormal_response_to1.00803275
65MP0002877_abnormal_melanocyte_morpholog1.00711345
66MP0003795_abnormal_bone_structure0.99972962
67MP0001661_extended_life_span0.99667633
68MP0008469_abnormal_protein_level0.98483923
69MP0000767_abnormal_smooth_muscle0.98184313
70MP0000639_abnormal_adrenal_gland0.94823776
71MP0003011_delayed_dark_adaptation0.93997172
72MP0002166_altered_tumor_susceptibility0.93130314
73MP0001790_abnormal_immune_system0.90447962
74MP0005387_immune_system_phenotype0.90447962
75MP0005025_abnormal_response_to0.90169891
76MP0001845_abnormal_inflammatory_respons0.89434615
77MP0004883_abnormal_blood_vessel0.88332732
78MP0005220_abnormal_exocrine_pancreas0.87984805
79MP0000230_abnormal_systemic_arterial0.87789826
80MP0002118_abnormal_lipid_homeostasis0.87358187
81MP0002896_abnormal_bone_mineralization0.87213997
82MP0002138_abnormal_hepatobiliary_system0.85587793
83MP0000516_abnormal_urinary_system0.83417994
84MP0005367_renal/urinary_system_phenotyp0.83417994
85MP0010386_abnormal_urinary_bladder0.82879723
86MP0002078_abnormal_glucose_homeostasis0.82531020
87MP0003045_fibrosis0.79779492
88MP0005397_hematopoietic_system_phenotyp0.79249183
89MP0001545_abnormal_hematopoietic_system0.79249183
90MP0001879_abnormal_lymphatic_vessel0.78162616
91MP0000249_abnormal_blood_vessel0.77787332
92MP0005332_abnormal_amino_acid0.77660704
93MP0005167_abnormal_blood-brain_barrier0.76850634
94MP0001853_heart_inflammation0.76581031
95MP0009643_abnormal_urine_homeostasis0.74896863
96MP0000465_gastrointestinal_hemorrhage0.74701946
97MP0010155_abnormal_intestine_physiology0.74527019
98MP0002060_abnormal_skin_morphology0.74310742
99MP0009278_abnormal_bone_marrow0.73860457
100MP0002405_respiratory_system_inflammati0.73386357

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.48074529
2Abnormality of liposaccharide metabolism (HP:0010968)4.48074529
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.48074529
4Premature rupture of membranes (HP:0001788)4.18693389
5Protrusio acetabuli (HP:0003179)4.18232124
6Dysostosis multiplex (HP:0000943)4.09511673
7Abnormality of polysaccharide metabolism (HP:0011012)3.91196563
8Abnormality of glycosaminoglycan metabolism (HP:0004371)3.91196563
9Abnormality of mucopolysaccharide metabolism (HP:0011020)3.91196563
10Vacuolated lymphocytes (HP:0001922)3.88634280
11Mucopolysacchariduria (HP:0008155)3.80262189
12Urinary glycosaminoglycan excretion (HP:0003541)3.80262189
13Petechiae (HP:0000967)3.66382569
14Nuclear cataract (HP:0100018)3.58378951
15Increased CSF protein (HP:0002922)3.26001765
16Mesangial abnormality (HP:0001966)3.04276561
17Progressive neurologic deterioration (HP:0002344)3.02645618
18Hematochezia (HP:0002573)2.92662814
19Vertebral compression fractures (HP:0002953)2.91735250
20Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89499439
21Purpura (HP:0000979)2.74214999
22Elevated erythrocyte sedimentation rate (HP:0003565)2.67969042
23Prolonged bleeding time (HP:0003010)2.66785159
24Mitral stenosis (HP:0001718)2.66036654
25Gingival bleeding (HP:0000225)2.64785147
26Abnormality of dentin (HP:0010299)2.62343868
27Hyperglycemia (HP:0003074)2.57058171
28Joint stiffness (HP:0001387)2.56242084
29Systemic lupus erythematosus (HP:0002725)2.45704321
30Episodic fever (HP:0001954)2.45067839
31Prolonged neonatal jaundice (HP:0006579)2.44785868
32J-shaped sella turcica (HP:0002680)2.44691860
33Abnormality of macrophages (HP:0004311)2.43737082
34Spondylolisthesis (HP:0003302)2.41619363
35Hypoglycemic seizures (HP:0002173)2.37600130
36Cervical subluxation (HP:0003308)2.34168022
37Cardiovascular calcification (HP:0011915)2.33446252
38Testicular neoplasm (HP:0010788)2.31873440
39Congenital malformation of the right heart (HP:0011723)2.31282906
40Double outlet right ventricle (HP:0001719)2.31282906
41Hyperlipoproteinemia (HP:0010980)2.31018855
42Xanthomatosis (HP:0000991)2.30690409
43Epistaxis (HP:0000421)2.25905704
44Loss of speech (HP:0002371)2.23828479
45Aortic dissection (HP:0002647)2.20463520
46Vascular calcification (HP:0004934)2.17901573
47Amyloidosis (HP:0011034)2.15468996
48Ovoid vertebral bodies (HP:0003300)2.13614072
49Peritonitis (HP:0002586)2.11271641
50Hypoglycemic coma (HP:0001325)2.09760953
51Cardiomegaly (HP:0001640)2.08936473
52Menorrhagia (HP:0000132)2.06961826
53Follicular hyperkeratosis (HP:0007502)2.04997770
54Growth hormone excess (HP:0000845)2.03572001
55Abnormality of the common coagulation pathway (HP:0010990)2.01517602
56Irregular vertebral endplates (HP:0003301)1.97561775
57Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96484574
58Tongue fasciculations (HP:0001308)1.94478455
59Genu recurvatum (HP:0002816)1.92870992
60Beaking of vertebral bodies (HP:0004568)1.91261071
61Stomatitis (HP:0010280)1.86447751
62Wormian bones (HP:0002645)1.84205717
63Albinism (HP:0001022)1.83090695
64Slender build (HP:0001533)1.82299458
65Zonular cataract (HP:0010920)1.81316642
66Orthostatic hypotension (HP:0001278)1.79855296
67Metaphyseal dysplasia (HP:0100255)1.79066769
68Bone cyst (HP:0012062)1.78219179
69Aortic aneurysm (HP:0004942)1.76962813
70Ketoacidosis (HP:0001993)1.76351779
71Asymmetric septal hypertrophy (HP:0001670)1.76334420
72Basal ganglia calcification (HP:0002135)1.75549629
73Glucose intolerance (HP:0000833)1.74456860
74Soft skin (HP:0000977)1.74436593
75Retinal atrophy (HP:0001105)1.74141705
76Large for gestational age (HP:0001520)1.74100602
77Cerebral aneurysm (HP:0004944)1.73655749
78Late onset (HP:0003584)1.72813554
79Joint swelling (HP:0001386)1.72273805
80Enlarged penis (HP:0000040)1.70737553
81Hypergammaglobulinemia (HP:0010702)1.70685383
82Cupped ribs (HP:0000887)1.70542811
83Insulin-resistant diabetes mellitus (HP:0000831)1.69166886
84Stroke (HP:0001297)1.68637543
85Large eyes (HP:0001090)1.68616332
86Insulin resistance (HP:0000855)1.68484893
87Striae distensae (HP:0001065)1.68277568
88Increased variability in muscle fiber diameter (HP:0003557)1.67277869
89Muscle fibrillation (HP:0010546)1.65889934
90Hypoplasia of the odontoid process (HP:0003311)1.65877115
91Spinal rigidity (HP:0003306)1.65876255
92Joint hemorrhage (HP:0005261)1.65142197
93Acne (HP:0001061)1.63858210
94Dilatation of the ascending aorta (HP:0005111)1.62340009
95Blue sclerae (HP:0000592)1.62092463
96Stridor (HP:0010307)1.61494637
97Dysautonomia (HP:0002459)1.60759606
98Increased cerebral lipofuscin (HP:0011813)1.60661453
99Spontaneous hematomas (HP:0007420)1.60171687
100Bladder diverticulum (HP:0000015)1.58729091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK12.87622757
2MYLK2.84457860
3FRK2.69375621
4ERN12.61498737
5KIT2.46360340
6KDR2.43816592
7TGFBR22.27584219
8LIMK12.21130761
9MOS2.15710655
10FLT31.71003325
11PIM21.67419739
12GRK71.67080823
13TIE11.63403073
14TAOK21.55118644
15DDR21.50107350
16GRK11.48310921
17TBK11.46793541
18ADRBK21.46579281
19MAPKAPK31.45542565
20ZAP701.40926193
21TESK21.39872429
22FES1.37558130
23MST41.34608147
24NME21.34586360
25NLK1.32117961
26MAP4K21.31881253
27TRPM71.31668535
28HIPK21.30665976
29PTK2B1.28132910
30ABL21.27239944
31LRRK21.24320032
32BCKDK1.23444590
33FER1.21594511
34MAP3K31.17387025
35PTK21.16720960
36MAP4K11.12310800
37EPHB21.11419669
38CSF1R1.09763646
39PHKG21.09153000
40PHKG11.09153000
41PRKD21.08163291
42STK101.07332194
43ARAF1.05584117
44TNK21.04615743
45IRAK31.04238466
46PIK3CG1.03042443
47TYK21.01408514
48MAP2K61.00259343
49JAK10.98747438
50IKBKB0.96290018
51TEC0.95985765
52MAP3K110.93470022
53FGFR30.93118723
54PRPF4B0.93039630
55CDC42BPA0.90319639
56DAPK20.89396754
57TAOK30.88460585
58CAMK2D0.88386933
59ILK0.87673231
60ROCK10.84965838
61ITK0.82615268
62DAPK30.79845300
63GSK3A0.78928605
64ROCK20.78517788
65NEK90.78119333
66TXK0.77687169
67FGFR20.77386737
68ADRBK10.72689551
69MAP2K30.72321807
70EPHB10.71918552
71JAK30.71674981
72SYK0.69600512
73MAP3K120.68693688
74PAK20.68465448
75DAPK10.65619371
76EPHA30.63290253
77PDK20.62656923
78PRKG20.61647390
79BTK0.59118144
80PRKCE0.59020729
81MAP3K10.58991397
82LCK0.58816909
83LYN0.58280678
84MAPK110.56411053
85PDGFRA0.56159223
86LMTK20.54815978
87IKBKE0.54484737
88GRK50.53532942
89HCK0.52936857
90SCYL20.51273857
91PRKD10.50070254
92PAK10.49474569
93MAP3K140.47596284
94MAPK70.45957056
95CSK0.45129754
96PLK20.44283097
97TAOK10.43974272
98PRKD30.43462722
99MAPKAPK20.43435381
100PAK40.42533954

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.80383967
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.66710058
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.64474137
4Sulfur metabolism_Homo sapiens_hsa009203.18540710
5Lysosome_Homo sapiens_hsa041422.49351413
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.45509721
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.14273262
8Type I diabetes mellitus_Homo sapiens_hsa049402.11962513
9Fatty acid elongation_Homo sapiens_hsa000621.77760689
10Complement and coagulation cascades_Homo sapiens_hsa046101.69925852
11Rheumatoid arthritis_Homo sapiens_hsa053231.65070605
12Folate biosynthesis_Homo sapiens_hsa007901.55020940
13Glutathione metabolism_Homo sapiens_hsa004801.42964172
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41134395
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.39353443
16Hematopoietic cell lineage_Homo sapiens_hsa046401.39214607
17Primary immunodeficiency_Homo sapiens_hsa053401.37489309
18Collecting duct acid secretion_Homo sapiens_hsa049661.35826797
19Vibrio cholerae infection_Homo sapiens_hsa051101.34576892
20Sphingolipid metabolism_Homo sapiens_hsa006001.32771273
21ECM-receptor interaction_Homo sapiens_hsa045121.29397812
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27876563
23Pertussis_Homo sapiens_hsa051331.26424896
24Protein export_Homo sapiens_hsa030601.25593911
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17711794
26Malaria_Homo sapiens_hsa051441.17028785
27Staphylococcus aureus infection_Homo sapiens_hsa051501.13075296
28Allograft rejection_Homo sapiens_hsa053301.11298938
29Arachidonic acid metabolism_Homo sapiens_hsa005901.08995174
30Peroxisome_Homo sapiens_hsa041461.08146381
31Platelet activation_Homo sapiens_hsa046111.07601372
32Butanoate metabolism_Homo sapiens_hsa006501.04333162
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03809452
34Phagosome_Homo sapiens_hsa041451.02431567
35Asthma_Homo sapiens_hsa053101.00614446
36Graft-versus-host disease_Homo sapiens_hsa053320.96255969
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95331780
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94158525
39Insulin secretion_Homo sapiens_hsa049110.89682095
40Autoimmune thyroid disease_Homo sapiens_hsa053200.89635349
41Protein digestion and absorption_Homo sapiens_hsa049740.88713641
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.88568442
43Amoebiasis_Homo sapiens_hsa051460.85653364
44Antigen processing and presentation_Homo sapiens_hsa046120.84420358
45Focal adhesion_Homo sapiens_hsa045100.80144010
46Galactose metabolism_Homo sapiens_hsa000520.79715806
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79362017
48Leishmaniasis_Homo sapiens_hsa051400.77745909
49PPAR signaling pathway_Homo sapiens_hsa033200.76554922
50Osteoclast differentiation_Homo sapiens_hsa043800.73856599
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72879547
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71964012
53Prion diseases_Homo sapiens_hsa050200.71748282
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71569562
55N-Glycan biosynthesis_Homo sapiens_hsa005100.71290366
56Salmonella infection_Homo sapiens_hsa051320.71158237
57Ovarian steroidogenesis_Homo sapiens_hsa049130.70396028
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68636669
59Shigellosis_Homo sapiens_hsa051310.68499380
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68070862
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67612353
62Oxidative phosphorylation_Homo sapiens_hsa001900.67493256
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67208083
64Chemical carcinogenesis_Homo sapiens_hsa052040.64885448
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61410484
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61404132
67Renin secretion_Homo sapiens_hsa049240.59905010
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.59854881
69Pentose phosphate pathway_Homo sapiens_hsa000300.58374689
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58155711
71Mineral absorption_Homo sapiens_hsa049780.57340264
72Renin-angiotensin system_Homo sapiens_hsa046140.55447641
73Tuberculosis_Homo sapiens_hsa051520.55161367
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.54526013
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53626595
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53238049
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51482375
78Fat digestion and absorption_Homo sapiens_hsa049750.50268908
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49457525
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.49308753
81Legionellosis_Homo sapiens_hsa051340.48029678
82Fatty acid degradation_Homo sapiens_hsa000710.47168621
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46956921
84African trypanosomiasis_Homo sapiens_hsa051430.46854776
85ABC transporters_Homo sapiens_hsa020100.46829834
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46576223
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45979421
88Tryptophan metabolism_Homo sapiens_hsa003800.44903989
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44891630
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44067981
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43564810
92Toxoplasmosis_Homo sapiens_hsa051450.43059661
93Dilated cardiomyopathy_Homo sapiens_hsa054140.42998561
94Fatty acid metabolism_Homo sapiens_hsa012120.42783723
95Endocytosis_Homo sapiens_hsa041440.41458737
96Vitamin digestion and absorption_Homo sapiens_hsa049770.40368521
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39817057
98TNF signaling pathway_Homo sapiens_hsa046680.39584686
99Regulation of autophagy_Homo sapiens_hsa041400.39302834
100* Leukocyte transendothelial migration_Homo sapiens_hsa046700.38689801

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