CD8BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)7.63510765
2cytidine deamination (GO:0009972)7.63510765
3cytidine metabolic process (GO:0046087)7.63510765
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.30135500
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.82434763
6Arp2/3 complex-mediated actin nucleation (GO:0034314)6.47985293
7DNA deamination (GO:0045006)6.34901248
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.97789551
9actin nucleation (GO:0045010)5.71841803
10negative T cell selection (GO:0043383)5.58991060
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44695287
12positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.10965291
13positive regulation of natural killer cell mediated immunity (GO:0002717)5.02644721
14positive T cell selection (GO:0043368)4.96496875
15cytolysis (GO:0019835)4.95356293
16negative regulation of stress fiber assembly (GO:0051497)4.84855484
17T cell migration (GO:0072678)4.84425566
18positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.72122023
19positive regulation of calcium-mediated signaling (GO:0050850)4.65472718
20negative regulation of T cell apoptotic process (GO:0070233)4.65451933
21sequestering of actin monomers (GO:0042989)4.62652565
22positive thymic T cell selection (GO:0045059)4.46346497
23regulation of B cell receptor signaling pathway (GO:0050855)4.44895050
24regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.40210630
25regulation of natural killer cell mediated immunity (GO:0002715)4.40210630
26positive regulation of tolerance induction (GO:0002645)4.35158647
27regulation of T cell tolerance induction (GO:0002664)4.31687553
28negative thymic T cell selection (GO:0045060)4.28903296
29regulation of leukocyte mediated cytotoxicity (GO:0001910)4.23800718
30positive regulation of cell killing (GO:0031343)4.16288778
31thymic T cell selection (GO:0045061)4.14612380
32positive regulation of T cell mediated cytotoxicity (GO:0001916)4.13615692
33regulation of activation of Janus kinase activity (GO:0010533)4.01308613
34regulation of defense response to virus by virus (GO:0050690)4.00292144
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.95873406
36positive regulation of gamma-delta T cell activation (GO:0046645)3.95691360
37regulation of chronic inflammatory response (GO:0002676)3.94702355
38regulation of regulatory T cell differentiation (GO:0045589)3.89464465
39T cell receptor signaling pathway (GO:0050852)3.85576345
40negative regulation by host of viral transcription (GO:0043922)3.82566496
41regulation of T cell mediated cytotoxicity (GO:0001914)3.82327845
42T cell selection (GO:0045058)3.80247164
43negative regulation of actin filament bundle assembly (GO:0032232)3.79931812
44positive regulation of interleukin-8 secretion (GO:2000484)3.77461405
45regulation of cell killing (GO:0031341)3.77203979
46cellular response to interleukin-15 (GO:0071350)3.75939643
47purine deoxyribonucleotide catabolic process (GO:0009155)3.70634710
48regulation of T cell receptor signaling pathway (GO:0050856)3.70141601
49positive regulation of B cell differentiation (GO:0045579)3.65223658
50negative regulation of calcium ion transport into cytosol (GO:0010523)3.60920941
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.58432978
52regulation of gamma-delta T cell differentiation (GO:0045586)3.57351083
53regulation of B cell differentiation (GO:0045577)3.57300440
54negative regulation of oxidoreductase activity (GO:0051354)3.55763309
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.55296816
56positive regulation of interleukin-4 production (GO:0032753)3.54030416
57regulation of T cell chemotaxis (GO:0010819)3.52796524
58positive regulation of T cell chemotaxis (GO:0010820)3.52796524
59negative regulation of viral genome replication (GO:0045071)3.52447246
60regulation of tolerance induction (GO:0002643)3.51410287
61regulation of interleukin-2 biosynthetic process (GO:0045076)3.44490958
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42729518
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.40677795
64regulation of cellular amino acid metabolic process (GO:0006521)3.38766570
65antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.36385055
66positive regulation of alpha-beta T cell proliferation (GO:0046641)3.35344562
67regulation of alpha-beta T cell proliferation (GO:0046640)3.34388000
68regulation of calcium-mediated signaling (GO:0050848)3.31859768
69positive regulation of uterine smooth muscle contraction (GO:0070474)3.30653006
70T cell costimulation (GO:0031295)3.29849799
71lymphocyte costimulation (GO:0031294)3.28229185
72regulation of lymphocyte chemotaxis (GO:1901623)3.27837001
73antigen receptor-mediated signaling pathway (GO:0050851)3.27278193
74regulation of isotype switching to IgG isotypes (GO:0048302)3.27268123
75pyrimidine nucleoside catabolic process (GO:0046135)3.26084876
76positive regulation of lamellipodium assembly (GO:0010592)3.24599113
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22933778
78lymphocyte migration (GO:0072676)3.21462114
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18942671
80eosinophil chemotaxis (GO:0048245)3.15351898
81regulation of interleukin-8 secretion (GO:2000482)3.11486338
82regulation of T cell apoptotic process (GO:0070232)3.10807551
83leukocyte aggregation (GO:0070486)3.09975024
84mast cell activation (GO:0045576)3.09077747
85respiratory burst (GO:0045730)3.08957377
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.08653355
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.08653355
88negative regulation of lymphocyte apoptotic process (GO:0070229)3.08111106
89positive regulation of lymphocyte mediated immunity (GO:0002708)3.06611340
90positive regulation of lymphocyte migration (GO:2000403)3.06579658
91positive regulation of monocyte chemotaxis (GO:0090026)3.05825668
92response to interleukin-15 (GO:0070672)3.03438840
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02605441
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02605441
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02605441
96regulation of gamma-delta T cell activation (GO:0046643)3.02259614
97interferon-gamma production (GO:0032609)3.00732177
98lymphocyte chemotaxis (GO:0048247)2.97738876
99antigen processing and presentation of endogenous antigen (GO:0019883)2.97296853
100positive regulation of defense response to virus by host (GO:0002230)2.96126449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.90613554
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.27678545
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.07494457
4ELF1_17652178_ChIP-ChIP_JURKAT_Human4.04540408
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.91787549
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.81283970
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29212647
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04465347
9MYB_26560356_Chip-Seq_TH2_Human2.92727119
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.86420074
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84009053
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82899256
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.82718666
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.56436676
15RUNX_20019798_ChIP-Seq_JUKART_Human2.50632065
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40999984
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.39216425
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25111563
19VDR_22108803_ChIP-Seq_LS180_Human2.24931501
20MYB_26560356_Chip-Seq_TH1_Human2.17856674
21GATA3_27048872_Chip-Seq_THYMUS_Human2.16341294
22UTX_26944678_Chip-Seq_JUKART_Human2.13502150
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00055468
24GATA3_26560356_Chip-Seq_TH2_Human1.94907241
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.83987172
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83383916
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73877211
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69288835
29MAF_26560356_Chip-Seq_TH2_Human1.68093065
30MAF_26560356_Chip-Seq_TH1_Human1.59639488
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54202116
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.46947171
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.46456881
34VDR_23849224_ChIP-Seq_CD4+_Human1.44925292
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42730207
36TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.40557449
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39865525
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38588983
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38474342
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31657271
41NANOG_20526341_ChIP-Seq_ESCs_Human1.23536573
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22395214
43BCL6_27268052_Chip-Seq_Bcells_Human1.21323760
44SPI1_23547873_ChIP-Seq_NB4_Human1.20856958
45PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20627151
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19959899
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19812628
48FOXP3_21729870_ChIP-Seq_TREG_Human1.18728751
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14697965
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13217065
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12216045
52HTT_18923047_ChIP-ChIP_STHdh_Human1.09997432
53TAF2_19829295_ChIP-Seq_ESCs_Human1.08808537
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.07291195
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.06191353
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.04066943
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00791507
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99456332
59SA1_27219007_Chip-Seq_Bcells_Human0.98426995
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97712819
61STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96394226
62SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96357279
63YY1_21170310_ChIP-Seq_MESCs_Mouse0.95619660
64RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95260136
65ER_23166858_ChIP-Seq_MCF-7_Human0.94026455
66BCOR_27268052_Chip-Seq_Bcells_Human0.93798277
67TP53_22573176_ChIP-Seq_HFKS_Human0.92809716
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92366628
69FOXA1_25329375_ChIP-Seq_VCAP_Human0.92030697
70FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92030697
71AR_20517297_ChIP-Seq_VCAP_Human0.91632701
72IRF8_27001747_Chip-Seq_BMDM_Mouse0.91335422
73NFE2_27457419_Chip-Seq_LIVER_Mouse0.91306090
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.91264280
75CTCF_20526341_ChIP-Seq_ESCs_Human0.90622740
76YY1_22570637_ChIP-Seq_MALME-3M_Human0.89178239
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89019134
78P300_27268052_Chip-Seq_Bcells_Human0.88775793
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87618721
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86486889
81GATA6_21074721_ChIP-Seq_CACO-2_Human0.86248038
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85859673
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85813512
84TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.85076681
85FOXH1_21741376_ChIP-Seq_ESCs_Human0.83764634
86CTCF_26484167_Chip-Seq_Bcells_Mouse0.83292929
87NCOR_22424771_ChIP-Seq_293T_Human0.83244590
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82273264
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82222333
90OCT4_20526341_ChIP-Seq_ESCs_Human0.82115270
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81334210
92ETS1_20019798_ChIP-Seq_JURKAT_Human0.80614128
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79877655
94E2F1_20622854_ChIP-Seq_HELA_Human0.78641348
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.78608980
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.78331638
97MYC_19829295_ChIP-Seq_ESCs_Human0.78011735
98GATA3_26560356_Chip-Seq_TH1_Human0.77305088
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76602855
100SPI1_20517297_ChIP-Seq_HL60_Human0.76457685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.41377714
2MP0009785_altered_susceptibility_to4.41866361
3MP0009333_abnormal_splenocyte_physiolog3.84074758
4MP0003763_abnormal_thymus_physiology3.51430217
5MP0001835_abnormal_antigen_presentation3.29214055
6MP0002166_altered_tumor_susceptibility3.23763224
7MP0005025_abnormal_response_to2.86240779
8MP0005000_abnormal_immune_tolerance2.85017204
9MP0001800_abnormal_humoral_immune2.56252657
10MP0002420_abnormal_adaptive_immunity2.46677121
11MP0005387_immune_system_phenotype2.43474166
12MP0001790_abnormal_immune_system2.43474166
13MP0002006_tumorigenesis2.39878913
14MP0001819_abnormal_immune_cell2.38371565
15MP0003866_abnormal_defecation2.37267635
16MP0002723_abnormal_immune_serum2.32726246
17MP0000685_abnormal_immune_system2.30525594
18MP0002102_abnormal_ear_morphology2.27841395
19MP0005645_abnormal_hypothalamus_physiol2.26244536
20MP0002148_abnormal_hypersensitivity_rea2.21028263
21MP0003045_fibrosis2.12460188
22MP0006082_CNS_inflammation2.02471771
23MP0002452_abnormal_antigen_presenting1.95214607
24MP0003436_decreased_susceptibility_to1.84006351
25MP0000716_abnormal_immune_system1.83770924
26MP0002405_respiratory_system_inflammati1.80802720
27MP0000703_abnormal_thymus_morphology1.79167494
28MP0002398_abnormal_bone_marrow1.79128515
29MP0001873_stomach_inflammation1.73524539
30MP0005075_abnormal_melanosome_morpholog1.72411448
31MP0003448_altered_tumor_morphology1.71010775
32MP0003878_abnormal_ear_physiology1.69979661
33MP0005377_hearing/vestibular/ear_phenot1.69979661
34MP0010155_abnormal_intestine_physiology1.68932047
35MP0001845_abnormal_inflammatory_respons1.60114977
36MP0002419_abnormal_innate_immunity1.54383219
37MP0002722_abnormal_immune_system1.50925322
38MP0000689_abnormal_spleen_morphology1.48234189
39MP0008872_abnormal_physiological_respon1.42730565
40MP0002429_abnormal_blood_cell1.37297159
41MP0000569_abnormal_digit_pigmentation1.36218647
42MP0002933_joint_inflammation1.35500486
43MP0001905_abnormal_dopamine_level1.34523247
44MP0001919_abnormal_reproductive_system1.31716701
45MP0002693_abnormal_pancreas_physiology1.29266502
46MP0003646_muscle_fatigue1.27295008
47MP0009764_decreased_sensitivity_to1.25211831
48MP0005464_abnormal_platelet_physiology1.23500950
49MP0008469_abnormal_protein_level1.22080843
50MP0001501_abnormal_sleep_pattern1.18547249
51MP0002163_abnormal_gland_morphology1.17078416
52MP0002736_abnormal_nociception_after1.16273526
53MP0003724_increased_susceptibility_to1.11706678
54MP0003806_abnormal_nucleotide_metabolis1.04489833
55MP0008875_abnormal_xenobiotic_pharmacok1.03577651
56MP0005379_endocrine/exocrine_gland_phen1.01852896
57MP0003137_abnormal_impulse_conducting1.00195543
58MP0004381_abnormal_hair_follicle0.99020366
59MP0005166_decreased_susceptibility_to0.97459325
60MP0004947_skin_inflammation0.97237390
61MP0002277_abnormal_respiratory_mucosa0.95085616
62MP0009763_increased_sensitivity_to0.93900183
63MP0001968_abnormal_touch/_nociception0.88652055
64MP0004134_abnormal_chest_morphology0.87964694
65MP0005389_reproductive_system_phenotype0.87874578
66MP0001533_abnormal_skeleton_physiology0.86561819
67MP0004145_abnormal_muscle_electrophysio0.83553796
68MP0002138_abnormal_hepatobiliary_system0.83377581
69MP0002019_abnormal_tumor_incidence0.83100343
70MP0003011_delayed_dark_adaptation0.82638608
71MP0002638_abnormal_pupillary_reflex0.80970363
72MP0001661_extended_life_span0.80873204
73MP0006036_abnormal_mitochondrial_physio0.79797566
74MP0005636_abnormal_mineral_homeostasis0.79612720
75MP0009643_abnormal_urine_homeostasis0.79377471
76MP0003786_premature_aging0.78862926
77MP0002837_dystrophic_cardiac_calcinosis0.74271844
78MP0000372_irregular_coat_pigmentation0.73742029
79MP0002095_abnormal_skin_pigmentation0.72279926
80MP0002132_abnormal_respiratory_system0.71963619
81MP0001765_abnormal_ion_homeostasis0.69906449
82MP0005310_abnormal_salivary_gland0.67606371
83MP0003252_abnormal_bile_duct0.67367274
84MP0005174_abnormal_tail_pigmentation0.63577681
85MP0002653_abnormal_ependyma_morphology0.63030174
86MP0008873_increased_physiological_sensi0.62147126
87MP0005410_abnormal_fertilization0.60457274
88MP0001542_abnormal_bone_strength0.58825829
89MP0003075_altered_response_to0.57691673
90MP0002136_abnormal_kidney_physiology0.56777479
91MP0005257_abnormal_intraocular_pressure0.54709179
92MP0001853_heart_inflammation0.53675664
93MP0004742_abnormal_vestibular_system0.53057101
94MP0002168_other_aberrant_phenotype0.52585602
95MP0004130_abnormal_muscle_cell0.52236525
96MP0005584_abnormal_enzyme/coenzyme_acti0.52154782
97MP0005551_abnormal_eye_electrophysiolog0.51420896
98MP0008995_early_reproductive_senescence0.50170508
99MP0000604_amyloidosis0.50074442
100MP0001119_abnormal_female_reproductive0.48921399

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)6.47627778
2Abnormality of T cell number (HP:0011839)6.13288673
3T lymphocytopenia (HP:0005403)6.07900061
4Autoimmune hemolytic anemia (HP:0001890)5.63559676
5Increased IgM level (HP:0003496)5.29689350
6Hypoproteinemia (HP:0003075)4.95569423
7IgG deficiency (HP:0004315)4.66547188
8Elevated erythrocyte sedimentation rate (HP:0003565)4.52714343
9Severe combined immunodeficiency (HP:0004430)4.52551465
10Abnormality of T cells (HP:0002843)4.42742258
11Abnormality of B cell number (HP:0010975)4.13408246
12Autoimmune thrombocytopenia (HP:0001973)3.63310037
13Chronic diarrhea (HP:0002028)3.61377307
14Combined immunodeficiency (HP:0005387)3.56684215
153-Methylglutaconic aciduria (HP:0003535)3.50223489
16Encephalitis (HP:0002383)3.45805594
17Congenital stationary night blindness (HP:0007642)3.43786087
18Abnormality of eosinophils (HP:0001879)3.43754036
19Thyroiditis (HP:0100646)3.34106631
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.32894817
21Increased intramyocellular lipid droplets (HP:0012240)3.32212921
22Abnormal mitochondria in muscle tissue (HP:0008316)3.21125559
23Eosinophilia (HP:0001880)3.19735662
24Mitochondrial inheritance (HP:0001427)3.15265571
25Pancytopenia (HP:0001876)3.12006341
26Acute necrotizing encephalopathy (HP:0006965)2.98132988
27Oral leukoplakia (HP:0002745)2.96136783
28Abnormality of macrophages (HP:0004311)2.94659135
29Stomatitis (HP:0010280)2.92621709
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.92041160
31IgM deficiency (HP:0002850)2.88769751
32Abnormality of T cell physiology (HP:0011840)2.88217121
33Hepatocellular necrosis (HP:0001404)2.85648069
34B lymphocytopenia (HP:0010976)2.81494278
35Acute hepatic failure (HP:0006554)2.80227803
36Stomach cancer (HP:0012126)2.80134173
37Hypergammaglobulinemia (HP:0010702)2.74797262
38Hepatic necrosis (HP:0002605)2.74567064
39Increased muscle lipid content (HP:0009058)2.74008535
40Myositis (HP:0100614)2.72023785
41Optic neuritis (HP:0100653)2.64388909
42Retrobulbar optic neuritis (HP:0100654)2.64388909
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62043181
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62043181
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.60953083
46Recurrent bronchitis (HP:0002837)2.52851719
47Leukocytosis (HP:0001974)2.50586751
48Granulocytopenia (HP:0001913)2.50501857
49Lymphopenia (HP:0001888)2.50243476
50Progressive macrocephaly (HP:0004481)2.49783639
51Amyotrophic lateral sclerosis (HP:0007354)2.48419650
52Lymphoma (HP:0002665)2.46303108
53Meningitis (HP:0001287)2.46180741
54Keratoconjunctivitis sicca (HP:0001097)2.38282035
55Generalized aminoaciduria (HP:0002909)2.37572644
56Recurrent viral infections (HP:0004429)2.36333882
57Increased CSF lactate (HP:0002490)2.35375074
58Abnormality of the pons (HP:0007361)2.29186925
59Keratoconjunctivitis (HP:0001096)2.26983152
60Type I transferrin isoform profile (HP:0003642)2.26597248
61Acute encephalopathy (HP:0006846)2.23645238
62Vasculitis (HP:0002633)2.22031967
63Abnormality of the renal cortex (HP:0011035)2.21710316
64Gastrointestinal infarctions (HP:0005244)2.20736473
65Renal cortical cysts (HP:0000803)2.16473874
66Abnormal rod and cone electroretinograms (HP:0008323)2.14971689
67Orchitis (HP:0100796)2.14267412
68Recurrent skin infections (HP:0001581)2.09617697
69Pustule (HP:0200039)2.08249579
70Premature graying of hair (HP:0002216)2.06202392
71Joint swelling (HP:0001386)2.04903027
72Hypoplasia of the pons (HP:0012110)2.03149443
73Severe visual impairment (HP:0001141)1.99945117
74Abnormality of the prostate (HP:0008775)1.98452603
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97807834
76Pulmonary infiltrates (HP:0002113)1.97092662
77Chronic mucocutaneous candidiasis (HP:0002728)1.96997074
78Recurrent cutaneous fungal infections (HP:0011370)1.96997074
79Gangrene (HP:0100758)1.95178926
80Increased hepatocellular lipid droplets (HP:0006565)1.94072723
81Abnormal albumin level (HP:0012116)1.91445440
82Hypoalbuminemia (HP:0003073)1.91445440
83Dicarboxylic aciduria (HP:0003215)1.89064375
84Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89064375
85Recurrent fungal infections (HP:0002841)1.87956237
86Cellular immunodeficiency (HP:0005374)1.86227335
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86082700
88Recurrent bacterial skin infections (HP:0005406)1.85974293
89Obstructive lung disease (HP:0006536)1.81907556
90Chronic obstructive pulmonary disease (HP:0006510)1.81907556
91Ketoacidosis (HP:0001993)1.80482800
92Hypochromic anemia (HP:0001931)1.80198037
93Recurrent otitis media (HP:0000403)1.79144446
94Attenuation of retinal blood vessels (HP:0007843)1.75028384
95Hemiplegia (HP:0002301)1.74248076
96Cerebral edema (HP:0002181)1.73807767
97Bronchitis (HP:0012387)1.73336732
98Bronchiectasis (HP:0002110)1.71067677
99Exercise intolerance (HP:0003546)1.70734193
100Renal Fanconi syndrome (HP:0001994)1.70731803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.78938567
2TESK25.84906206
3TXK4.69386903
4TESK13.46084196
5SCYL23.43815049
6MAP3K122.71402975
7LIMK12.38275232
8MAP4K12.36481475
9VRK22.35714574
10ITK2.32958404
11PASK2.20321811
12TLK12.15928398
13ADRBK22.10504980
14BCKDK1.91616943
15PINK11.87917427
16WNK41.61027693
17ZAK1.44371676
18ZAP701.41702151
19MAP3K111.41640252
20CAMKK21.31991658
21CSK1.27799947
22PRKCQ1.27702707
23GRK11.26955279
24GRK71.26409210
25MYLK1.25410372
26BUB11.25087566
27SYK1.25062057
28FES1.23728062
29GRK61.21974979
30IKBKE1.19717351
31LCK1.18417397
32VRK11.16977901
33TEC1.13523409
34DAPK11.11033052
35TAOK31.08967415
36NME11.06107555
37MST41.01983474
38CAMKK11.01838081
39MAP2K60.98321651
40BTK0.97398737
41MAPKAPK30.91724937
42TAOK20.91473276
43IRAK40.90808271
44RIPK40.85330364
45ROCK10.82631828
46CDK190.81855166
47NEK90.80536810
48FRK0.79471320
49CLK10.79351178
50EIF2AK30.76248218
51STK390.73104609
52OXSR10.69924564
53LYN0.69461110
54RPS6KA40.65861236
55JAK30.64605183
56ILK0.61765526
57RPS6KA50.60115748
58BLK0.57834795
59ERBB30.53625746
60FYN0.52456023
61TRPM70.51493897
62MAP4K20.48105772
63IKBKB0.47966868
64HCK0.47023245
65PIK3CG0.46825893
66INSRR0.44933886
67IGF1R0.44144953
68PIM10.43799590
69OBSCN0.43414121
70NEK60.37970152
71GRK50.37950165
72MAP3K50.35371937
73ADRBK10.33524563
74PRKCA0.32886035
75TIE10.31472038
76AURKA0.30431762
77MAP3K30.30133343
78STK100.29924328
79CAMK2A0.28412036
80CAMK10.27321009
81JAK20.24692997
82INSR0.23726432
83NUAK10.23215053
84MUSK0.22506351
85PRKACA0.22383193
86KIT0.22169936
87CSNK1G30.21565105
88PRKCH0.21251808
89DAPK30.20615043
90PAK10.19937984
91PDK10.18914691
92MAPKAPK20.18554115
93TBK10.18263373
94ERBB20.16674445
95ABL10.16407444
96TAOK10.16353794
97LRRK20.15605199
98PRKCD0.15562882
99PIM20.14361082
100CSNK2A10.11620651

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.00890929
2Proteasome_Homo sapiens_hsa030504.93462351
3Antigen processing and presentation_Homo sapiens_hsa046123.57172178
4T cell receptor signaling pathway_Homo sapiens_hsa046603.06985153
5Hematopoietic cell lineage_Homo sapiens_hsa046403.03553549
6Oxidative phosphorylation_Homo sapiens_hsa001902.96276961
7Graft-versus-host disease_Homo sapiens_hsa053322.84130451
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.76412866
9Autoimmune thyroid disease_Homo sapiens_hsa053202.54347567
10Parkinsons disease_Homo sapiens_hsa050122.48122293
11Allograft rejection_Homo sapiens_hsa053302.43651182
12Type I diabetes mellitus_Homo sapiens_hsa049402.36467399
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10357894
14Measles_Homo sapiens_hsa051621.76016063
15Alzheimers disease_Homo sapiens_hsa050101.70440979
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64738392
17Protein export_Homo sapiens_hsa030601.63316773
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.59232968
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.58950240
20Ribosome_Homo sapiens_hsa030101.55033989
21Malaria_Homo sapiens_hsa051441.26980888
22Huntingtons disease_Homo sapiens_hsa050161.26921680
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25939861
24Cardiac muscle contraction_Homo sapiens_hsa042601.25372225
25Salmonella infection_Homo sapiens_hsa051321.14426587
26Shigellosis_Homo sapiens_hsa051311.11634601
27Rheumatoid arthritis_Homo sapiens_hsa053231.11576203
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08098592
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.06799281
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05512191
31Viral myocarditis_Homo sapiens_hsa054160.98896639
32Intestinal immune network for IgA production_Homo sapiens_hsa046720.97620893
33Phototransduction_Homo sapiens_hsa047440.96199371
34NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95142574
35RNA polymerase_Homo sapiens_hsa030200.91666095
36Nitrogen metabolism_Homo sapiens_hsa009100.89893018
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88400948
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87734360
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86259448
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85008286
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83979980
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79927756
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75704714
44Caffeine metabolism_Homo sapiens_hsa002320.73640342
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63466072
46Peroxisome_Homo sapiens_hsa041460.60910575
47Herpes simplex infection_Homo sapiens_hsa051680.60485209
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58600119
49Retinol metabolism_Homo sapiens_hsa008300.58340083
50Chemical carcinogenesis_Homo sapiens_hsa052040.56576203
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55363806
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.55092455
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54586945
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52780006
55Chemokine signaling pathway_Homo sapiens_hsa040620.48792574
56Asthma_Homo sapiens_hsa053100.48033582
57Systemic lupus erythematosus_Homo sapiens_hsa053220.46317033
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45727540
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45269645
60Legionellosis_Homo sapiens_hsa051340.44628105
61Prion diseases_Homo sapiens_hsa050200.42010033
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.41855781
63ABC transporters_Homo sapiens_hsa020100.41137830
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.40555820
65Olfactory transduction_Homo sapiens_hsa047400.40075743
66Collecting duct acid secretion_Homo sapiens_hsa049660.40013663
67Homologous recombination_Homo sapiens_hsa034400.40002272
68African trypanosomiasis_Homo sapiens_hsa051430.39751368
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38880278
70Sulfur metabolism_Homo sapiens_hsa009200.38570906
71Pyrimidine metabolism_Homo sapiens_hsa002400.38073444
72Endocytosis_Homo sapiens_hsa041440.36049482
73Pertussis_Homo sapiens_hsa051330.35658319
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34897463
75Apoptosis_Homo sapiens_hsa042100.34502678
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33254690
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32558119
78Purine metabolism_Homo sapiens_hsa002300.32151937
79Staphylococcus aureus infection_Homo sapiens_hsa051500.31555389
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29833980
81Osteoclast differentiation_Homo sapiens_hsa043800.28504117
82Butanoate metabolism_Homo sapiens_hsa006500.27228718
83TNF signaling pathway_Homo sapiens_hsa046680.24950964
84Amphetamine addiction_Homo sapiens_hsa050310.24470949
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23582587
86Morphine addiction_Homo sapiens_hsa050320.23572001
87One carbon pool by folate_Homo sapiens_hsa006700.23350369
88Linoleic acid metabolism_Homo sapiens_hsa005910.22018759
89Spliceosome_Homo sapiens_hsa030400.20137208
90Pyruvate metabolism_Homo sapiens_hsa006200.19771453
91N-Glycan biosynthesis_Homo sapiens_hsa005100.19484127
92Metabolic pathways_Homo sapiens_hsa011000.18032882
93Leishmaniasis_Homo sapiens_hsa051400.17828078
94Vitamin digestion and absorption_Homo sapiens_hsa049770.17522364
95Taste transduction_Homo sapiens_hsa047420.17165267
96DNA replication_Homo sapiens_hsa030300.17012755
97Tryptophan metabolism_Homo sapiens_hsa003800.15611111
98Salivary secretion_Homo sapiens_hsa049700.15467016
99Fructose and mannose metabolism_Homo sapiens_hsa000510.15461955
100Epstein-Barr virus infection_Homo sapiens_hsa051690.14964690

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