CD8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.16051501
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.05297229
3negative T cell selection (GO:0043383)6.82456672
4positive regulation of gamma-delta T cell activation (GO:0046645)6.55980583
5regulation of B cell receptor signaling pathway (GO:0050855)6.54834732
6T cell migration (GO:0072678)6.50202578
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.14632536
8negative regulation of cell killing (GO:0031342)6.14632536
9negative thymic T cell selection (GO:0045060)5.86388923
10positive T cell selection (GO:0043368)5.78101741
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.77643453
12cytidine metabolic process (GO:0046087)5.42595893
13cytidine catabolic process (GO:0006216)5.42595893
14cytidine deamination (GO:0009972)5.42595893
15cellular response to interleukin-15 (GO:0071350)5.41462910
16positive thymic T cell selection (GO:0045059)5.37953636
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.36626524
18antigen processing and presentation of endogenous antigen (GO:0019883)5.31966229
19regulation of gamma-delta T cell differentiation (GO:0045586)5.21333952
20thymic T cell selection (GO:0045061)5.18209559
21regulation of natural killer cell mediated immunity (GO:0002715)5.06747619
22regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.06747619
23pyrimidine ribonucleoside catabolic process (GO:0046133)4.97902293
24T cell selection (GO:0045058)4.97872099
25response to interleukin-15 (GO:0070672)4.96928303
26regulation of T cell tolerance induction (GO:0002664)4.94686649
27positive regulation of natural killer cell mediated immunity (GO:0002717)4.88680803
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.85029954
29leukocyte aggregation (GO:0070486)4.83904072
30regulation of gamma-delta T cell activation (GO:0046643)4.79606914
31Arp2/3 complex-mediated actin nucleation (GO:0034314)4.67932062
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.67086303
33positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.61732862
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.52492071
35regulation of leukocyte mediated cytotoxicity (GO:0001910)4.46209196
36regulation of alpha-beta T cell proliferation (GO:0046640)4.43590875
37positive regulation of calcium-mediated signaling (GO:0050850)4.41463160
38positive regulation of T cell mediated cytotoxicity (GO:0001916)4.39795722
39positive regulation of tolerance induction (GO:0002645)4.38403199
40T cell receptor signaling pathway (GO:0050852)4.37405247
41regulation of T cell mediated cytotoxicity (GO:0001914)4.27162121
42DNA deamination (GO:0045006)4.25325397
43positive regulation of cell killing (GO:0031343)4.22767157
44regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.22412497
45regulation of tolerance induction (GO:0002643)4.18040718
46positive regulation of alpha-beta T cell proliferation (GO:0046641)4.16787744
47activated T cell proliferation (GO:0050798)4.16109094
48regulation of B cell differentiation (GO:0045577)4.14131841
49regulation of cell killing (GO:0031341)4.03223316
50regulation of interleukin-2 biosynthetic process (GO:0045076)3.98766796
51actin nucleation (GO:0045010)3.96103834
52lymphocyte migration (GO:0072676)3.94605365
53antigen receptor-mediated signaling pathway (GO:0050851)3.94064243
54respiratory burst (GO:0045730)3.93010393
55lymphocyte chemotaxis (GO:0048247)3.91080713
56antigen processing and presentation via MHC class Ib (GO:0002475)3.85254885
57negative regulation of T cell apoptotic process (GO:0070233)3.80936980
58positive regulation of B cell differentiation (GO:0045579)3.80834353
59regulation of isotype switching to IgG isotypes (GO:0048302)3.72764223
60regulation of T cell receptor signaling pathway (GO:0050856)3.72448142
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.70129675
62regulation of regulatory T cell differentiation (GO:0045589)3.66112269
63cytolysis (GO:0019835)3.65864477
64negative regulation of lymphocyte mediated immunity (GO:0002707)3.61921124
65interferon-gamma production (GO:0032609)3.60093362
66negative regulation of stress fiber assembly (GO:0051497)3.53530086
67negative regulation of leukocyte mediated immunity (GO:0002704)3.52216443
68positive regulation of granulocyte differentiation (GO:0030854)3.51218988
69negative regulation of execution phase of apoptosis (GO:1900118)3.50538938
70mast cell activation (GO:0045576)3.49632292
71regulation of activation of Janus kinase activity (GO:0010533)3.49251710
72negative regulation of T cell mediated immunity (GO:0002710)3.48835650
73T cell costimulation (GO:0031295)3.48569592
74lymphocyte costimulation (GO:0031294)3.44965856
75cellular response to type I interferon (GO:0071357)3.44192832
76type I interferon signaling pathway (GO:0060337)3.44192832
77response to type I interferon (GO:0034340)3.40900409
78positive regulation of interleukin-4 production (GO:0032753)3.38730174
79signal complex assembly (GO:0007172)3.36078242
80B cell receptor signaling pathway (GO:0050853)3.33939919
81cellular defense response (GO:0006968)3.30367929
82positive regulation of lymphocyte mediated immunity (GO:0002708)3.29889574
83negative regulation of viral genome replication (GO:0045071)3.24777464
84immunoglobulin mediated immune response (GO:0016064)3.23678104
85detection of bacterium (GO:0016045)3.22256629
86positive regulation of interleukin-2 production (GO:0032743)3.21792608
87dendritic cell chemotaxis (GO:0002407)3.20730552
88regulation of lymphocyte chemotaxis (GO:1901623)3.20129418
89positive regulation of T cell mediated immunity (GO:0002711)3.19657695
90detection of other organism (GO:0098543)3.13975193
91regulation of calcium-mediated signaling (GO:0050848)3.13799406
92T cell mediated immunity (GO:0002456)3.10127408
93negative regulation of interleukin-12 production (GO:0032695)3.09390514
94negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.07638131
95positive regulation of humoral immune response (GO:0002922)3.04775793
96regulation of T cell mediated immunity (GO:0002709)3.03883973
97negative regulation of phagocytosis (GO:0050765)3.02557320
98NIK/NF-kappaB signaling (GO:0038061)3.02379378
99positive regulation of T cell chemotaxis (GO:0010820)3.00339997
100regulation of T cell chemotaxis (GO:0010819)3.00339997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.94474292
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.85461075
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.27633613
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.25173356
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.66571162
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.69331609
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.67109861
8MYB_26560356_Chip-Seq_TH2_Human3.42483719
9RUNX_20019798_ChIP-Seq_JUKART_Human3.39883303
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.27774368
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13892112
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.98797354
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86248406
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.81951240
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.81615329
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.81245810
17UTX_26944678_Chip-Seq_JUKART_Human2.76166948
18MYB_26560356_Chip-Seq_TH1_Human2.69734120
19MAF_26560356_Chip-Seq_TH1_Human2.63619109
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.53982377
21* GATA3_27048872_Chip-Seq_THYMUS_Human2.45301298
22MAF_26560356_Chip-Seq_TH2_Human2.27225891
23SPI1_23547873_ChIP-Seq_NB4_Human2.18735216
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.10349633
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08308820
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04743234
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96550279
28GATA3_26560356_Chip-Seq_TH2_Human1.90202872
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80695874
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67782060
31MYC_22102868_ChIP-Seq_BL_Human1.66112860
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65275976
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.63868682
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63312616
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.62171293
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.56546211
37VDR_24763502_ChIP-Seq_THP-1_Human1.55744711
38SCL_19346495_ChIP-Seq_HPC-7_Human1.52173907
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51911888
40SPI1_23127762_ChIP-Seq_K562_Human1.48462817
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45742619
42VDR_21846776_ChIP-Seq_THP-1_Human1.43535658
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41506996
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41484969
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39113941
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38763399
47BCL6_27268052_Chip-Seq_Bcells_Human1.35862687
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34876753
49CIITA_25753668_ChIP-Seq_RAJI_Human1.32487762
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22985740
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21888793
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21710481
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20669843
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18316220
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14874649
56BCOR_27268052_Chip-Seq_Bcells_Human1.10539234
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07181126
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05796870
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05150683
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03637852
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03472415
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01568101
63VDR_23849224_ChIP-Seq_CD4+_Human1.01382330
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00255499
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00215181
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99334251
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98487805
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96620502
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95277019
70RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92606874
71KDM2B_26808549_Chip-Seq_DND41_Human0.91638909
72TCF7_22412390_ChIP-Seq_EML_Mouse0.91484747
73ELF1_20517297_ChIP-Seq_JURKAT_Human0.91350342
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89444655
75P300_27268052_Chip-Seq_Bcells_Human0.89320844
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88463225
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86645222
78SA1_27219007_Chip-Seq_Bcells_Human0.84109709
79SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83820426
80FOXP3_21729870_ChIP-Seq_TREG_Human0.83273613
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82418585
82SPI1_20517297_ChIP-Seq_HL60_Human0.81939989
83VDR_24787735_ChIP-Seq_THP-1_Human0.80053924
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79941094
85YY1_22570637_ChIP-Seq_MALME-3M_Human0.79616172
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79365138
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78607047
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76568278
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76411038
90CTCF_27219007_Chip-Seq_ERYTHROID_Human0.76019061
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75780680
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74349456
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73588891
94* GATA3_26560356_Chip-Seq_TH1_Human0.73427401
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73111950
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.72934982
97NANOG_20526341_ChIP-Seq_ESCs_Human0.72516082
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71234307
99E2F1_20622854_ChIP-Seq_HELA_Human0.70348293
100P68_20966046_ChIP-Seq_HELA_Human0.69348296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.24195307
2MP0003763_abnormal_thymus_physiology4.45880753
3MP0001835_abnormal_antigen_presentation3.96832073
4MP0009785_altered_susceptibility_to3.93276013
5MP0003436_decreased_susceptibility_to3.42962112
6MP0001800_abnormal_humoral_immune3.25277352
7MP0005000_abnormal_immune_tolerance3.18897755
8MP0005025_abnormal_response_to3.15426986
9MP0009333_abnormal_splenocyte_physiolog3.05508143
10MP0003724_increased_susceptibility_to2.96579991
11MP0002420_abnormal_adaptive_immunity2.92914065
12MP0000685_abnormal_immune_system2.89719919
13MP0005387_immune_system_phenotype2.89505836
14MP0001790_abnormal_immune_system2.89505836
15MP0002723_abnormal_immune_serum2.86466660
16MP0001819_abnormal_immune_cell2.85897424
17MP0006082_CNS_inflammation2.80020956
18MP0003866_abnormal_defecation2.72140365
19MP0002166_altered_tumor_susceptibility2.55803861
20MP0002452_abnormal_antigen_presenting2.54409141
21MP0002419_abnormal_innate_immunity2.46075277
22MP0002405_respiratory_system_inflammati2.43441161
23MP0002148_abnormal_hypersensitivity_rea2.31989263
24MP0002398_abnormal_bone_marrow2.31678982
25MP0000716_abnormal_immune_system2.23685905
26MP0000703_abnormal_thymus_morphology2.17184452
27MP0010155_abnormal_intestine_physiology2.16469376
28MP0002722_abnormal_immune_system1.88003889
29MP0000689_abnormal_spleen_morphology1.86387675
30MP0004381_abnormal_hair_follicle1.86133938
31MP0001845_abnormal_inflammatory_respons1.84942982
32MP0003045_fibrosis1.82788625
33MP0002006_tumorigenesis1.79031244
34MP0002429_abnormal_blood_cell1.72534341
35MP0001873_stomach_inflammation1.66875058
36MP0003300_gastrointestinal_ulcer1.64971111
37MP0005464_abnormal_platelet_physiology1.61531322
38MP0001533_abnormal_skeleton_physiology1.58013482
39MP0003448_altered_tumor_morphology1.54037390
40MP0004947_skin_inflammation1.53973624
41MP0008469_abnormal_protein_level1.44461328
42MP0005075_abnormal_melanosome_morpholog1.33116756
43MP0005451_abnormal_body_composition1.29903564
44MP0002933_joint_inflammation1.28524633
45MP0002132_abnormal_respiratory_system1.27472610
46MP0002277_abnormal_respiratory_mucosa1.20504488
47MP0003303_peritoneal_inflammation1.17026981
48MP0005166_decreased_susceptibility_to1.14087951
49MP0003878_abnormal_ear_physiology1.06406226
50MP0005377_hearing/vestibular/ear_phenot1.06406226
51MP0000858_altered_metastatic_potential1.03346486
52MP0009763_increased_sensitivity_to0.99640387
53MP0003183_abnormal_peptide_metabolism0.98814739
54MP0005310_abnormal_salivary_gland0.96246731
55MP0002396_abnormal_hematopoietic_system0.93553847
56MP0008260_abnormal_autophagy0.92384856
57MP0009764_decreased_sensitivity_to0.90395443
58MP0003806_abnormal_nucleotide_metabolis0.87682477
59MP0000490_abnormal_crypts_of0.87451084
60MP0002693_abnormal_pancreas_physiology0.85868802
61MP0004883_abnormal_blood_vessel0.84930554
62MP0002019_abnormal_tumor_incidence0.81554019
63MP0003690_abnormal_glial_cell0.80171341
64MP0002102_abnormal_ear_morphology0.77752444
65MP0002138_abnormal_hepatobiliary_system0.74450704
66MP0005645_abnormal_hypothalamus_physiol0.73483725
67MP0002998_abnormal_bone_remodeling0.72867091
68MP0003252_abnormal_bile_duct0.72292923
69MP0001851_eye_inflammation0.71613886
70MP0003191_abnormal_cellular_cholesterol0.71054065
71MP0002163_abnormal_gland_morphology0.69671829
72MP0003172_abnormal_lysosome_physiology0.66693864
73MP0001853_heart_inflammation0.66542794
74MP0001348_abnormal_lacrimal_gland0.62539796
75MP0001919_abnormal_reproductive_system0.60472491
76MP0009643_abnormal_urine_homeostasis0.60242651
77MP0001765_abnormal_ion_homeostasis0.60210251
78MP0003075_altered_response_to0.59917624
79MP0000920_abnormal_myelination0.58469792
80MP0002168_other_aberrant_phenotype0.58384510
81MP0002136_abnormal_kidney_physiology0.56488640
82MP0001663_abnormal_digestive_system0.56171485
83MP0001986_abnormal_taste_sensitivity0.54650182
84MP0000604_amyloidosis0.51400145
85MP0000465_gastrointestinal_hemorrhage0.51229269
86MP0008873_increased_physiological_sensi0.51227449
87MP0005390_skeleton_phenotype0.50904235
88MP0001501_abnormal_sleep_pattern0.49797559
89MP0003795_abnormal_bone_structure0.49487513
90MP0005164_abnormal_response_to0.47871455
91MP0008872_abnormal_physiological_respon0.46827283
92MP0005379_endocrine/exocrine_gland_phen0.46702296
93MP0009765_abnormal_xenobiotic_induced0.46097071
94MP0001905_abnormal_dopamine_level0.45179001
95MP0009642_abnormal_blood_homeostasis0.43892732
96MP0005319_abnormal_enzyme/_coenzyme0.42751672
97MP0005584_abnormal_enzyme/coenzyme_acti0.41646426
98MP0004130_abnormal_muscle_cell0.41129655
99MP0000569_abnormal_digit_pigmentation0.39335956
100MP0003011_delayed_dark_adaptation0.39016520

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.74839132
2Abnormality of T cell number (HP:0011839)7.16146763
3Elevated erythrocyte sedimentation rate (HP:0003565)6.16512970
4Abnormality of T cells (HP:0002843)5.19700161
5Stomatitis (HP:0010280)5.18164277
6Severe combined immunodeficiency (HP:0004430)5.04220953
7Aplastic anemia (HP:0001915)4.94986866
8Eczematoid dermatitis (HP:0000976)4.73769726
9Abnormality of macrophages (HP:0004311)4.68340668
10Myositis (HP:0100614)4.64202072
11Increased IgM level (HP:0003496)4.53099950
12IgG deficiency (HP:0004315)4.52127215
13Recurrent bacterial skin infections (HP:0005406)4.40539616
14Recurrent abscess formation (HP:0002722)4.28160856
15Autoimmune hemolytic anemia (HP:0001890)4.27083137
16Gastrointestinal infarctions (HP:0005244)4.25878368
17Encephalitis (HP:0002383)4.23706628
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.08284758
19Combined immunodeficiency (HP:0005387)4.03433195
20Recurrent fungal infections (HP:0002841)3.88735208
21Retrobulbar optic neuritis (HP:0100654)3.88475417
22Optic neuritis (HP:0100653)3.88475417
23Orchitis (HP:0100796)3.82048226
24Meningitis (HP:0001287)3.79528243
25Chronic diarrhea (HP:0002028)3.74146303
26IgM deficiency (HP:0002850)3.73449104
27Hypoproteinemia (HP:0003075)3.72316384
28Recurrent viral infections (HP:0004429)3.66642525
29Recurrent cutaneous fungal infections (HP:0011370)3.63555119
30Chronic mucocutaneous candidiasis (HP:0002728)3.63555119
31Lymphopenia (HP:0001888)3.51965702
32Recurrent skin infections (HP:0001581)3.49140503
33Abnormality of eosinophils (HP:0001879)3.47734746
34Recurrent bronchitis (HP:0002837)3.41255546
35Chronic obstructive pulmonary disease (HP:0006510)3.40767904
36Obstructive lung disease (HP:0006536)3.40767904
37Abnormality of cells of the lymphoid lineage (HP:0012140)3.33556667
38Leukocytosis (HP:0001974)3.32604438
39Abnormality of B cell number (HP:0010975)3.32426809
40Acute hepatic failure (HP:0006554)3.31835002
41Thyroiditis (HP:0100646)3.30952403
42Mediastinal lymphadenopathy (HP:0100721)3.25013665
43Vasculitis (HP:0002633)3.18983636
44Keratoconjunctivitis sicca (HP:0001097)3.16154849
45Pustule (HP:0200039)3.13850950
46Abnormality of T cell physiology (HP:0011840)3.12539918
47Eosinophilia (HP:0001880)3.06535751
48B lymphocytopenia (HP:0010976)3.04370752
49Panhypogammaglobulinemia (HP:0003139)3.03561859
50Granulocytopenia (HP:0001913)2.98069132
51Spontaneous hematomas (HP:0007420)2.94816421
52Keratoconjunctivitis (HP:0001096)2.94489225
53Recurrent gram-negative bacterial infections (HP:0005420)2.91525267
54Hypergammaglobulinemia (HP:0010702)2.90594285
55Pulmonary infiltrates (HP:0002113)2.81362659
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.80557628
57Chest pain (HP:0100749)2.79612025
58Increased IgE level (HP:0003212)2.73575070
59Hypoplasia of the thymus (HP:0000778)2.68167434
60Hypochromic microcytic anemia (HP:0004840)2.67370762
61Lymphoma (HP:0002665)2.67344276
62Agammaglobulinemia (HP:0004432)2.64348708
63Autoimmune thrombocytopenia (HP:0001973)2.59176276
64Hypochromic anemia (HP:0001931)2.56614268
65Urticaria (HP:0001025)2.50145324
66Anorexia (HP:0002039)2.49543628
67Joint swelling (HP:0001386)2.48431188
68Inflammation of the large intestine (HP:0002037)2.47255486
69Hemoptysis (HP:0002105)2.44515799
70Pulmonary embolism (HP:0002204)2.35882552
71Gastrointestinal inflammation (HP:0004386)2.33478239
72Arterial thrombosis (HP:0004420)2.31106057
73Gangrene (HP:0100758)2.28937896
74Pancytopenia (HP:0001876)2.26123758
75Abnormality of the prostate (HP:0008775)2.23415701
76Microcytic anemia (HP:0001935)2.20713392
77Bronchitis (HP:0012387)2.18003004
78Episodic fever (HP:0001954)2.08746036
79Abnormality of the pleura (HP:0002103)2.08106721
80Gingival bleeding (HP:0000225)2.07266527
81Recurrent otitis media (HP:0000403)2.06644149
82Gingivitis (HP:0000230)2.06024938
83Petechiae (HP:0000967)2.04141407
84Epistaxis (HP:0000421)2.00280106
85Chronic otitis media (HP:0000389)1.93885010
86Sepsis (HP:0100806)1.93833880
87Keratitis (HP:0000491)1.93351057
88Hemiplegia (HP:0002301)1.89016640
89Slow saccadic eye movements (HP:0000514)1.88204696
90Amyotrophic lateral sclerosis (HP:0007354)1.87720954
91Aplasia/Hypoplasia of the thymus (HP:0010515)1.86789806
92Skin rash (HP:0000988)1.83690962
93Glomerulopathy (HP:0100820)1.82172859
94Nasal polyposis (HP:0100582)1.80474673
95Abnormal rod and cone electroretinograms (HP:0008323)1.80149242
96Acne (HP:0001061)1.76982430
97Amaurosis fugax (HP:0100576)1.76480007
98Colitis (HP:0002583)1.75297355
99Oral leukoplakia (HP:0002745)1.73579109
100Prolonged bleeding time (HP:0003010)1.71581161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.14669883
2KDR4.65062401
3TESK24.41580299
4TXK3.94234628
5RIPK42.94027313
6FES2.81997978
7ITK2.81486105
8SCYL22.67785316
9CSK2.60887550
10GRK62.54532751
11ZAP702.45221140
12BTK2.20854339
13TAOK32.17640819
14MAP3K112.12494337
15TEC2.08087623
16SYK1.96840337
17TESK11.96452392
18IKBKE1.84944680
19IRAK41.81368812
20LCK1.77654651
21TYK21.67257735
22BLK1.60441820
23TNK21.59783566
24JAK31.53250093
25PASK1.49497336
26PRKCQ1.46825262
27HCK1.42202797
28MAP3K121.40472435
29LYN1.31784825
30GRK71.21033176
31ERN11.18853230
32PRPF4B1.15092058
33TBK11.15060689
34STK101.14949584
35CAMKK21.13605092
36MAP2K31.09447577
37TAOK21.07719536
38MAP3K31.04998167
39JAK11.01184641
40TAOK11.00474092
41BCKDK0.93507098
42CAMKK10.92342191
43ADRBK20.90737715
44CSF1R0.89460778
45MARK30.82953324
46JAK20.82169604
47LIMK10.79722138
48FYN0.78910617
49EPHB10.70595695
50SIK30.69913362
51PIK3CG0.69519656
52IKBKB0.68889102
53FGR0.68067649
54MAP3K140.67746149
55NLK0.65390570
56LRRK20.65384920
57PRKCH0.64394247
58PDK10.61416510
59PIM10.61046446
60CLK10.58359917
61CDK40.56648079
62TLK10.55988862
63MAP2K60.55571653
64MAPK110.54329593
65MAPKAPK30.53277398
66BMPR20.51201405
67MAP3K10.50743948
68MAP3K50.50063902
69TYRO30.49193489
70KIT0.48734706
71CDK190.45976247
72TGFBR20.44789231
73DAPK10.43619968
74VRK20.42763888
75SIK20.39612916
76PTK60.39583802
77MAPKAPK20.39138278
78NEK60.38606785
79INSR0.36481033
80MAP3K70.35566938
81IGF1R0.30095191
82MAP3K130.28130736
83RPS6KA40.27314915
84TRPM70.26858395
85HIPK20.26580831
86FGFR40.26234473
87EIF2AK30.25660020
88GRK50.21334437
89ROCK10.21098617
90MYLK0.20294097
91PRKCD0.19958464
92FGFR30.19154794
93MST40.19023396
94ADRBK10.17991673
95ABL10.17301711
96WNK40.16708373
97RPS6KA50.16597136
98PRKD20.16427629
99PDGFRB0.15905193
100NME10.15442886

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053406.37100911
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.70764096
3Graft-versus-host disease_Homo sapiens_hsa053323.68865070
4* T cell receptor signaling pathway_Homo sapiens_hsa046603.49121847
5Allograft rejection_Homo sapiens_hsa053303.30944163
6* Antigen processing and presentation_Homo sapiens_hsa046123.20880060
7Autoimmune thyroid disease_Homo sapiens_hsa053203.18828395
8* Hematopoietic cell lineage_Homo sapiens_hsa046402.68036639
9Measles_Homo sapiens_hsa051622.65397095
10Type I diabetes mellitus_Homo sapiens_hsa049402.64662947
11Proteasome_Homo sapiens_hsa030502.37120968
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.29043849
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20924023
14Osteoclast differentiation_Homo sapiens_hsa043801.92619050
15Viral myocarditis_Homo sapiens_hsa054161.88349204
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87938565
17Malaria_Homo sapiens_hsa051441.83222251
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79220103
19Leishmaniasis_Homo sapiens_hsa051401.77909872
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60206884
21Chemokine signaling pathway_Homo sapiens_hsa040621.57813968
22Staphylococcus aureus infection_Homo sapiens_hsa051501.51356924
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.47619735
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46864940
25Herpes simplex infection_Homo sapiens_hsa051681.43929686
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43688442
27B cell receptor signaling pathway_Homo sapiens_hsa046621.39114935
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36884393
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34032026
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.31642704
31Shigellosis_Homo sapiens_hsa051311.31497677
32Salmonella infection_Homo sapiens_hsa051321.30964645
33* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24973691
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10590201
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05853749
36Rheumatoid arthritis_Homo sapiens_hsa053231.05849801
37Tuberculosis_Homo sapiens_hsa051521.04407701
38Asthma_Homo sapiens_hsa053100.99063490
39Influenza A_Homo sapiens_hsa051640.92067686
40TNF signaling pathway_Homo sapiens_hsa046680.90232024
41Legionellosis_Homo sapiens_hsa051340.88882928
42African trypanosomiasis_Homo sapiens_hsa051430.88167136
43Apoptosis_Homo sapiens_hsa042100.84926317
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.84830022
45Endocytosis_Homo sapiens_hsa041440.77708822
46Platelet activation_Homo sapiens_hsa046110.75090031
47Toxoplasmosis_Homo sapiens_hsa051450.74112951
48Epstein-Barr virus infection_Homo sapiens_hsa051690.72822199
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71092386
50HTLV-I infection_Homo sapiens_hsa051660.71030806
51Oxidative phosphorylation_Homo sapiens_hsa001900.70748262
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69787231
53Parkinsons disease_Homo sapiens_hsa050120.66005964
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65726858
55Regulation of autophagy_Homo sapiens_hsa041400.63982635
56Pertussis_Homo sapiens_hsa051330.63419801
57Phagosome_Homo sapiens_hsa041450.60620424
58Hepatitis B_Homo sapiens_hsa051610.56841095
59Acute myeloid leukemia_Homo sapiens_hsa052210.55161129
60Viral carcinogenesis_Homo sapiens_hsa052030.54240330
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48142761
62Ribosome_Homo sapiens_hsa030100.45566259
63Hepatitis C_Homo sapiens_hsa051600.42563586
64Non-small cell lung cancer_Homo sapiens_hsa052230.38682257
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38180299
66Systemic lupus erythematosus_Homo sapiens_hsa053220.37817378
67Alzheimers disease_Homo sapiens_hsa050100.35415153
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33723907
69VEGF signaling pathway_Homo sapiens_hsa043700.33678534
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32778492
71Pancreatic cancer_Homo sapiens_hsa052120.30845764
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25791339
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25072792
74MAPK signaling pathway_Homo sapiens_hsa040100.24080969
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.23558973
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21800543
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21149129
78Prion diseases_Homo sapiens_hsa050200.19905274
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19178780
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.19102898
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.18077649
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15421948
83Ras signaling pathway_Homo sapiens_hsa040140.14657530
84Olfactory transduction_Homo sapiens_hsa047400.13536303
85FoxO signaling pathway_Homo sapiens_hsa040680.11994226
86Rap1 signaling pathway_Homo sapiens_hsa040150.10674641
87Caffeine metabolism_Homo sapiens_hsa002320.09023398
88RNA polymerase_Homo sapiens_hsa030200.08608294
89Insulin resistance_Homo sapiens_hsa049310.07408116
90ABC transporters_Homo sapiens_hsa020100.05994720
91Prolactin signaling pathway_Homo sapiens_hsa049170.05751201
92Collecting duct acid secretion_Homo sapiens_hsa049660.05028327
93Long-term potentiation_Homo sapiens_hsa047200.05010407
94Huntingtons disease_Homo sapiens_hsa050160.02737980
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.02566286
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.00958981
97Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0178935
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0096369
99Phototransduction_Homo sapiens_hsa04744-0.0095745
100Lysosome_Homo sapiens_hsa04142-0.0060996

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