CD8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1V(D)J recombination (GO:0033151)9.72748979
2activated T cell proliferation (GO:0050798)9.55204919
3positive T cell selection (GO:0043368)9.37925378
4negative T cell selection (GO:0043383)9.37695747
5regulation of gamma-delta T cell differentiation (GO:0045586)9.11283351
6negative regulation of thymocyte apoptotic process (GO:0070244)9.04165488
7positive regulation of gamma-delta T cell activation (GO:0046645)8.74499462
8regulation of gamma-delta T cell activation (GO:0046643)8.21860830
9T cell selection (GO:0045058)7.90606990
10cytidine deamination (GO:0009972)7.78388020
11cytidine metabolic process (GO:0046087)7.78388020
12cytidine catabolic process (GO:0006216)7.78388020
13interferon-gamma production (GO:0032609)7.53533112
14pyrimidine ribonucleoside catabolic process (GO:0046133)7.13679283
15negative thymic T cell selection (GO:0045060)6.86101691
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.78011839
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.75258625
18T cell receptor signaling pathway (GO:0050852)6.64740598
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.46362441
20positive thymic T cell selection (GO:0045059)6.45220128
21negative regulation of cell killing (GO:0031342)6.37574594
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.37574594
23thymic T cell selection (GO:0045061)5.97826249
24alpha-beta T cell differentiation (GO:0046632)5.89262675
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.85867545
26DNA deamination (GO:0045006)5.69105298
27alpha-beta T cell activation (GO:0046631)5.61549526
28regulation of thymocyte apoptotic process (GO:0070243)5.55704652
29T cell costimulation (GO:0031295)5.38725146
30antigen receptor-mediated signaling pathway (GO:0050851)5.29668607
31lymphocyte costimulation (GO:0031294)5.27317595
32negative regulation of T cell apoptotic process (GO:0070233)5.22917671
33* T cell differentiation (GO:0030217)5.19582977
34positive regulation of interleukin-2 production (GO:0032743)5.07524750
35regulation of isotype switching to IgG isotypes (GO:0048302)5.03873568
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.78152601
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.78152601
38regulation of activation of Janus kinase activity (GO:0010533)4.74607568
39Peyers patch development (GO:0048541)4.70159684
40mucosal-associated lymphoid tissue development (GO:0048537)4.70159684
41regulation of interleukin-2 biosynthetic process (GO:0045076)4.69067057
42regulation of T cell receptor signaling pathway (GO:0050856)4.67761179
43mast cell activation (GO:0045576)4.62822686
44somatic diversification of immune receptors via germline recombination within a single locus (GO:0004.61794915
45somatic cell DNA recombination (GO:0016444)4.61794915
46positive regulation of natural killer cell mediated immunity (GO:0002717)4.54666998
47positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.54666998
48regulation of regulatory T cell differentiation (GO:0045589)4.48270272
49regulation of T cell tolerance induction (GO:0002664)4.41621908
50regulation of lymphocyte chemotaxis (GO:1901623)4.38430649
51regulation of T cell chemotaxis (GO:0010819)4.38173958
52positive regulation of T cell chemotaxis (GO:0010820)4.38173958
53regulation of natural killer cell mediated immunity (GO:0002715)4.34346016
54regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.34346016
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.33436700
56response to interleukin-15 (GO:0070672)4.32609076
57T cell migration (GO:0072678)4.31866131
58regulation of B cell differentiation (GO:0045577)4.26600806
59T cell homeostasis (GO:0043029)4.24779375
60positive regulation of T cell mediated cytotoxicity (GO:0001916)4.24569437
61somatic diversification of immune receptors (GO:0002200)4.20200000
62Arp2/3 complex-mediated actin nucleation (GO:0034314)4.19804323
63regulation of T cell mediated cytotoxicity (GO:0001914)4.16589531
64positive regulation of B cell differentiation (GO:0045579)4.12318222
65modulation by virus of host process (GO:0019054)4.11770815
66T cell differentiation in thymus (GO:0033077)4.10170109
67* T cell activation (GO:0042110)4.08514157
68antigen processing and presentation of endogenous antigen (GO:0019883)4.00377905
69negative regulation of viral genome replication (GO:0045071)4.00145843
70CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.99342095
71regulation of defense response to virus by virus (GO:0050690)3.98834388
72lymphocyte chemotaxis (GO:0048247)3.97820270
73dendritic cell chemotaxis (GO:0002407)3.97512054
74regulation of interleukin-2 production (GO:0032663)3.93052392
75genitalia morphogenesis (GO:0035112)3.91630718
76mast cell activation involved in immune response (GO:0002279)3.90817708
77mast cell degranulation (GO:0043303)3.90817708
78cellular response to interleukin-15 (GO:0071350)3.87883047
79negative regulation by host of viral transcription (GO:0043922)3.84851343
80lymphocyte migration (GO:0072676)3.84777181
81regulation of B cell receptor signaling pathway (GO:0050855)3.83364514
82leukocyte aggregation (GO:0070486)3.79914049
83T cell proliferation (GO:0042098)3.79136214
84positive regulation of lymphocyte migration (GO:2000403)3.78093630
85positive regulation of alpha-beta T cell proliferation (GO:0046641)3.76225856
86positive regulation of isotype switching (GO:0045830)3.75452856
87eosinophil chemotaxis (GO:0048245)3.74350111
88negative regulation of lymphocyte apoptotic process (GO:0070229)3.70722911
89positive regulation of monocyte chemotaxis (GO:0090026)3.69211175
90cellular defense response (GO:0006968)3.67435313
91positive regulation of cell killing (GO:0031343)3.66493639
92T cell differentiation involved in immune response (GO:0002292)3.63477081
93alpha-beta T cell differentiation involved in immune response (GO:0002293)3.63477081
94alpha-beta T cell activation involved in immune response (GO:0002287)3.63477081
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.62661147
96positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.62094061
97negative regulation of T cell receptor signaling pathway (GO:0050860)3.61521330
98CD4-positive, alpha-beta T cell activation (GO:0035710)3.60519821
99immune response-activating cell surface receptor signaling pathway (GO:0002429)3.59921430
100antigen processing and presentation via MHC class Ib (GO:0002475)3.58116381
101modulation by symbiont of host cellular process (GO:0044068)3.54733799
102regulation of response to tumor cell (GO:0002834)3.54573124
103positive regulation of response to tumor cell (GO:0002836)3.54573124
104positive regulation of immune response to tumor cell (GO:0002839)3.54573124
105regulation of immune response to tumor cell (GO:0002837)3.54573124
106regulation of alpha-beta T cell proliferation (GO:0046640)3.54340751
107cytolysis (GO:0019835)3.53351505
108positive regulation of interleukin-8 secretion (GO:2000484)3.52954251
109actin nucleation (GO:0045010)3.52474491
110positive regulation of tolerance induction (GO:0002645)3.52269888
111negative regulation of lymphocyte mediated immunity (GO:0002707)3.51034677
112dendritic cell migration (GO:0036336)3.50687967
113T-helper cell differentiation (GO:0042093)3.50511922
114CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.50511922
115negative regulation of leukocyte mediated immunity (GO:0002704)3.50331369
116granulocyte activation (GO:0036230)3.49728913
117pyrimidine nucleoside catabolic process (GO:0046135)3.47371265
118* lymphocyte differentiation (GO:0030098)3.46588700
119respiratory burst (GO:0045730)3.40491965
120neutrophil activation (GO:0042119)3.39901923
121lymphocyte homeostasis (GO:0002260)3.39383006
122regulation of chronic inflammatory response (GO:0002676)3.38717031
123eosinophil migration (GO:0072677)3.36436729
124regulation of leukocyte mediated cytotoxicity (GO:0001910)3.36407469
125regulation of cell killing (GO:0031341)3.32615293
126regulation of T cell apoptotic process (GO:0070232)3.29874915
127regulation of lymphocyte migration (GO:2000401)3.29716785
128negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.28216837
129positive regulation of granulocyte differentiation (GO:0030854)3.25989876
130macrophage chemotaxis (GO:0048246)3.25573249
131positive regulation of T cell migration (GO:2000406)3.25171759
132positive regulation of DNA recombination (GO:0045911)3.24489767
133cellular response to type I interferon (GO:0071357)3.24386116
134type I interferon signaling pathway (GO:0060337)3.24386116
135response to type I interferon (GO:0034340)3.20864399
136positive regulation of B cell mediated immunity (GO:0002714)3.20530830
137positive regulation of immunoglobulin mediated immune response (GO:0002891)3.20530830
138B cell receptor signaling pathway (GO:0050853)3.20183664
139positive regulation of T cell activation (GO:0050870)3.20016622
140positive regulation of defense response to virus by host (GO:0002230)3.19393886
141positive regulation of interleukin-4 production (GO:0032753)3.18502875
142cellular hyperosmotic response (GO:0071474)3.16241150
143T cell lineage commitment (GO:0002360)3.13754518
144negative regulation of T cell mediated immunity (GO:0002710)3.13541310
145positive regulation of lymphocyte mediated immunity (GO:0002708)3.10953523
146signal complex assembly (GO:0007172)3.10156152
147immunoglobulin mediated immune response (GO:0016064)3.09380387
148* positive regulation of calcium-mediated signaling (GO:0050850)3.09045932
149regulation of tolerance induction (GO:0002643)3.08376974
150chemokine-mediated signaling pathway (GO:0070098)3.08324158
151regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.06895180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.42736323
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.07610728
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.30914493
4E2F7_22180533_ChIP-Seq_HELA_Human4.90397438
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.22854014
6RUNX_20019798_ChIP-Seq_JUKART_Human4.16485163
7* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse4.10721698
8MYC_22102868_ChIP-Seq_BL_Human4.07360673
9MYB_26560356_Chip-Seq_TH2_Human3.79080704
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.55019989
11UTX_26944678_Chip-Seq_JUKART_Human3.20228157
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05559032
13MAF_26560356_Chip-Seq_TH1_Human3.01455464
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.99140546
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89823443
16MYB_26560356_Chip-Seq_TH1_Human2.80922522
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.77817424
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70118323
19* GATA3_27048872_Chip-Seq_THYMUS_Human2.69368657
20VDR_21846776_ChIP-Seq_THP-1_Human2.44974778
21TCF7_22412390_ChIP-Seq_EML_Mouse2.39379347
22* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.36624848
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26592108
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.23302777
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19886811
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15360099
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.06554789
28KDM2B_26808549_Chip-Seq_DND41_Human2.05306735
29SCL_19346495_ChIP-Seq_HPC-7_Human1.99487784
30MAF_26560356_Chip-Seq_TH2_Human1.98999399
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.95528429
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91629656
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91285036
34VDR_24763502_ChIP-Seq_THP-1_Human1.83676064
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82880406
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79568909
37CIITA_25753668_ChIP-Seq_RAJI_Human1.78176794
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.71374091
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70025007
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.67693974
41SPI1_23547873_ChIP-Seq_NB4_Human1.64251032
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.58510700
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55629281
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54502663
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50424217
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49826199
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48222624
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.45134960
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43478811
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42951574
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37130422
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37090836
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35293990
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35209335
55SPI1_23127762_ChIP-Seq_K562_Human1.34791862
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33411879
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32791380
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32206575
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.29894402
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26706872
61GATA3_26560356_Chip-Seq_TH2_Human1.26551134
62BCL6_27268052_Chip-Seq_Bcells_Human1.25811034
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24218067
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.23865368
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23654048
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21448421
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16722264
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15350293
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08252453
70PU_27001747_Chip-Seq_BMDM_Mouse1.07061251
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.05261994
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01243271
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00640855
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00174262
75BCOR_27268052_Chip-Seq_Bcells_Human0.99828247
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98925835
77TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97563734
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95860133
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94777958
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94673043
81FOXP3_21729870_ChIP-Seq_TREG_Human0.94396124
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93830974
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93417948
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91765311
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91674596
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91132496
87P300_27268052_Chip-Seq_Bcells_Human0.90609791
88NCOR1_26117541_ChIP-Seq_K562_Human0.89781564
89VDR_23849224_ChIP-Seq_CD4+_Human0.87968668
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85418168
91FOXO3_23340844_ChIP-Seq_DLD1_Human0.85154014
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85006260
93SA1_27219007_Chip-Seq_Bcells_Human0.83856204
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.82334308
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80875400
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.78570028
97SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.78388892
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78220780
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78131382
100NANOG_20526341_ChIP-Seq_ESCs_Human0.77819494
101GATA1_22025678_ChIP-Seq_K562_Human0.77724192
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76038735
103GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.75598247
104* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75329968
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75073537
106PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73956109
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72868293
108* GATA2_19941826_ChIP-Seq_K562_Human0.72547744
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.71546054
110RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69986644
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69274900
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69146602
113YY1_22570637_ChIP-Seq_MALME-3M_Human0.68982462
114VDR_24787735_ChIP-Seq_THP-1_Human0.68813485
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.68703552
116ELK1_19687146_ChIP-ChIP_HELA_Human0.68345526
117KDM5A_27292631_Chip-Seq_BREAST_Human0.68325542
118PKCTHETA_26484144_Chip-Seq_BREAST_Human0.67600182
119SPI1_20517297_ChIP-Seq_HL60_Human0.67468763
120HOXB4_20404135_ChIP-ChIP_EML_Mouse0.67081912
121GATA3_26560356_Chip-Seq_TH1_Human0.66857642
122TAF2_19829295_ChIP-Seq_ESCs_Human0.66518477
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66498262
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.66239668
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66212006
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65243931
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64485779
128GATA1_19941826_ChIP-Seq_K562_Human0.62915633
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.60935409
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.60266211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.99201234
2MP0002166_altered_tumor_susceptibility4.49912970
3MP0002132_abnormal_respiratory_system4.10631132
4MP0000703_abnormal_thymus_morphology3.88194643
5* MP0005671_abnormal_response_to3.63760991
6MP0002006_tumorigenesis3.60203704
7MP0005409_darkened_coat_color3.35925560
8MP0000685_abnormal_immune_system3.11296613
9MP0009785_altered_susceptibility_to2.98087792
10MP0004947_skin_inflammation2.82199917
11* MP0002398_abnormal_bone_marrow2.80624590
12MP0001835_abnormal_antigen_presentation2.79096638
13MP0010155_abnormal_intestine_physiology2.62869454
14MP0001800_abnormal_humoral_immune2.60455112
15MP0006082_CNS_inflammation2.58350247
16MP0002722_abnormal_immune_system2.50962666
17MP0009333_abnormal_splenocyte_physiolog2.49920016
18* MP0002420_abnormal_adaptive_immunity2.42596534
19MP0001790_abnormal_immune_system2.42203197
20MP0005387_immune_system_phenotype2.42203197
21* MP0001819_abnormal_immune_cell2.37951323
22* MP0000716_abnormal_immune_system2.33701621
23MP0002723_abnormal_immune_serum2.31186665
24MP0002405_respiratory_system_inflammati2.27967723
25MP0005000_abnormal_immune_tolerance2.26613275
26MP0009278_abnormal_bone_marrow2.23467386
27MP0001849_ear_inflammation2.18562287
28MP0000689_abnormal_spleen_morphology2.17951570
29MP0005174_abnormal_tail_pigmentation2.12430046
30MP0002933_joint_inflammation2.07419460
31MP0000015_abnormal_ear_pigmentation2.00547182
32MP0002452_abnormal_antigen_presenting1.94044736
33* MP0005025_abnormal_response_to1.87226147
34MP0004808_abnormal_hematopoietic_stem1.85531675
35MP0002095_abnormal_skin_pigmentation1.84979919
36* MP0002429_abnormal_blood_cell1.84857789
37MP0010094_abnormal_chromosome_stability1.83860670
38MP0003045_fibrosis1.79557657
39MP0003300_gastrointestinal_ulcer1.57520158
40MP0001545_abnormal_hematopoietic_system1.57488353
41MP0005397_hematopoietic_system_phenotyp1.57488353
42MP0002148_abnormal_hypersensitivity_rea1.54785203
43MP0002396_abnormal_hematopoietic_system1.50114478
44MP0000858_altered_metastatic_potential1.49562199
45MP0001873_stomach_inflammation1.47461891
46MP0001845_abnormal_inflammatory_respons1.46660475
47MP0002277_abnormal_respiratory_mucosa1.43995083
48MP0005464_abnormal_platelet_physiology1.40479753
49MP0002419_abnormal_innate_immunity1.35308582
50MP0003866_abnormal_defecation1.34378386
51MP0002009_preneoplasia1.30925654
52MP0003436_decreased_susceptibility_to1.25500282
53MP0003724_increased_susceptibility_to1.22117604
54MP0003183_abnormal_peptide_metabolism1.15349089
55MP0000490_abnormal_crypts_of1.14250107
56MP0002019_abnormal_tumor_incidence1.11521574
57MP0003448_altered_tumor_morphology1.05325752
58MP0005166_decreased_susceptibility_to1.04433765
59MP0004381_abnormal_hair_follicle1.03537812
60MP0001243_abnormal_dermal_layer1.03519902
61MP0001879_abnormal_lymphatic_vessel1.01503107
62MP0009764_decreased_sensitivity_to1.01445132
63MP0004130_abnormal_muscle_cell0.98875688
64MP0002998_abnormal_bone_remodeling0.97680458
65MP0002075_abnormal_coat/hair_pigmentati0.95537880
66MP0002163_abnormal_gland_morphology0.88865526
67MP0003172_abnormal_lysosome_physiology0.87591799
68MP0008961_abnormal_basal_metabolism0.85477201
69MP0010352_gastrointestinal_tract_polyps0.83750605
70MP0001853_heart_inflammation0.83658318
71MP0003075_altered_response_to0.82757511
72MP0002138_abnormal_hepatobiliary_system0.82453631
73MP0000569_abnormal_digit_pigmentation0.82426597
74MP0002876_abnormal_thyroid_physiology0.79731854
75MP0008569_lethality_at_weaning0.79669341
76MP0002693_abnormal_pancreas_physiology0.78878671
77MP0005076_abnormal_cell_differentiation0.78298030
78MP0005310_abnormal_salivary_gland0.75487923
79MP0008057_abnormal_DNA_replication0.74790779
80MP0004883_abnormal_blood_vessel0.73018775
81MP0008770_decreased_survivor_rate0.72140077
82MP0001186_pigmentation_phenotype0.71486518
83MP0006035_abnormal_mitochondrial_morpho0.71312552
84MP0008873_increased_physiological_sensi0.71175796
85MP0008469_abnormal_protein_level0.71014195
86MP0005365_abnormal_bile_salt0.69613023
87MP0003959_abnormal_lean_body0.69473374
88MP0003690_abnormal_glial_cell0.65446887
89MP0000604_amyloidosis0.63548075
90MP0001919_abnormal_reproductive_system0.63409371
91MP0001986_abnormal_taste_sensitivity0.61662951
92MP0008260_abnormal_autophagy0.61647716
93MP0001851_eye_inflammation0.61238048
94MP0003077_abnormal_cell_cycle0.60842314
95MP0000383_abnormal_hair_follicle0.60804594
96MP0000609_abnormal_liver_physiology0.60519353
97MP0005075_abnormal_melanosome_morpholog0.60505792
98MP0003191_abnormal_cellular_cholesterol0.58393749
99MP0003786_premature_aging0.58192671
100MP0005451_abnormal_body_composition0.57246812
101MP0001663_abnormal_digestive_system0.57214698
102MP0003303_peritoneal_inflammation0.56297405
103MP0003806_abnormal_nucleotide_metabolis0.55990432
104MP0000477_abnormal_intestine_morphology0.55281447
105MP0001765_abnormal_ion_homeostasis0.55278720
106MP0000367_abnormal_coat/_hair0.54920918
107MP0002168_other_aberrant_phenotype0.54564684
108MP0005390_skeleton_phenotype0.54158810
109MP0000372_irregular_coat_pigmentation0.54102874
110MP0005164_abnormal_response_to0.53806750
111MP0003693_abnormal_embryo_hatching0.53065852
112MP0009643_abnormal_urine_homeostasis0.52649085
113MP0002971_abnormal_brown_adipose0.50181172
114MP0004510_myositis0.49759367
115MP0004957_abnormal_blastocyst_morpholog0.49302556
116MP0005319_abnormal_enzyme/_coenzyme0.48866236
117MP0003878_abnormal_ear_physiology0.48682463
118MP0005377_hearing/vestibular/ear_phenot0.48682463
119MP0003011_delayed_dark_adaptation0.48164139
120MP0005584_abnormal_enzyme/coenzyme_acti0.48024934
121MP0008007_abnormal_cellular_replicative0.48003840
122MP0002970_abnormal_white_adipose0.47222069
123MP0003787_abnormal_imprinting0.46899617
124* MP0002083_premature_death0.46753255
125MP0008874_decreased_physiological_sensi0.46356884
126MP0009765_abnormal_xenobiotic_induced0.46235606
127MP0002136_abnormal_kidney_physiology0.46065480
128MP0002877_abnormal_melanocyte_morpholog0.45998391
129MP0006054_spinal_hemorrhage0.45957802
130* MP0001191_abnormal_skin_condition0.45722090
131MP0005379_endocrine/exocrine_gland_phen0.43948466
132MP0010307_abnormal_tumor_latency0.41973079
133MP0003795_abnormal_bone_structure0.40988947
134MP0009642_abnormal_blood_homeostasis0.40424027
135MP0001216_abnormal_epidermal_layer0.40106556
136MP0001533_abnormal_skeleton_physiology0.40069132
137MP0004145_abnormal_muscle_electrophysio0.39926550
138MP0000465_gastrointestinal_hemorrhage0.39654462
139MP0009763_increased_sensitivity_to0.38985285
140MP0009115_abnormal_fat_cell0.37874760

Predicted human phenotypes

RankGene SetZ-score
1* T lymphocytopenia (HP:0005403)9.93979606
2B lymphocytopenia (HP:0010976)9.88947918
3Abnormality of B cell number (HP:0010975)9.88947918
4Severe combined immunodeficiency (HP:0004430)9.66293193
5Hypoplasia of the thymus (HP:0000778)9.55178450
6* Abnormality of T cell number (HP:0011839)9.41905260
7Panhypogammaglobulinemia (HP:0003139)8.95873553
8Thyroiditis (HP:0100646)8.75592980
9Combined immunodeficiency (HP:0005387)8.66268353
10Eosinophilia (HP:0001880)7.84962264
11Hypoproteinemia (HP:0003075)6.54290264
12Granulocytopenia (HP:0001913)6.43348774
13Abnormality of eosinophils (HP:0001879)6.17831215
14* Recurrent viral infections (HP:0004429)5.43810566
15* Abnormality of T cells (HP:0002843)4.94169387
16Recurrent fungal infections (HP:0002841)4.93114590
17IgG deficiency (HP:0004315)4.82533663
18Abnormality of macrophages (HP:0004311)4.77917335
19Leukocytosis (HP:0001974)4.63586049
20Erythroderma (HP:0001019)4.38577518
21Aplastic anemia (HP:0001915)4.14096254
22Aplasia/Hypoplasia of the thymus (HP:0010515)3.44535857
23Abnormality of the fingertips (HP:0001211)3.35480838
24Elevated erythrocyte sedimentation rate (HP:0003565)3.20774749
25Pulmonary infiltrates (HP:0002113)3.19703598
26Meningitis (HP:0001287)3.08022532
27Recurrent gram-negative bacterial infections (HP:0005420)2.93268008
28Pustule (HP:0200039)2.88355982
29Acute hepatic failure (HP:0006554)2.88070078
30Abnormality of the thymus (HP:0000777)2.82405207
31Hemiplegia (HP:0002301)2.82020076
32Keratoconjunctivitis (HP:0001096)2.79376200
33Nasal polyposis (HP:0100582)2.73914742
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.67278066
35Autoimmune thrombocytopenia (HP:0001973)2.65508012
36Gangrene (HP:0100758)2.61494667
37Hypochromic anemia (HP:0001931)2.57702526
38Lymphoma (HP:0002665)2.52071279
39Abnormality of the prostate (HP:0008775)2.48203504
40Abnormality of the pleura (HP:0002103)2.44114658
41Cellular immunodeficiency (HP:0005374)2.42688257
42Episodic fever (HP:0001954)2.40498014
43Recurrent cutaneous fungal infections (HP:0011370)2.40473189
44Chronic mucocutaneous candidiasis (HP:0002728)2.40473189
45Urticaria (HP:0001025)2.36458772
46Anorexia (HP:0002039)2.35500801
47Chronic otitis media (HP:0000389)2.34910099
48Joint swelling (HP:0001386)2.31161691
49Hypochromic microcytic anemia (HP:0004840)2.27986626
50Myositis (HP:0100614)2.22975422
51Gingivitis (HP:0000230)2.20742765
52Arterial thrombosis (HP:0004420)2.20451267
53Encephalitis (HP:0002383)2.19930508
54Abnormality of the nasal mucosa (HP:0000433)2.18801479
55Stomatitis (HP:0010280)2.13313661
56Keratitis (HP:0000491)2.12268947
57Increased serum ferritin (HP:0003281)2.11799789
58Recurrent bronchitis (HP:0002837)2.11258377
59Skin rash (HP:0000988)2.04681709
60Verrucae (HP:0200043)2.02188388
61Papilloma (HP:0012740)2.02188388
62Sepsis (HP:0100806)2.01598605
63Bicuspid aortic valve (HP:0001647)2.01118369
64Hypoalbuminemia (HP:0003073)2.00918311
65Abnormal albumin level (HP:0012116)2.00918311
66Microcytic anemia (HP:0001935)2.00749804
67Basal cell carcinoma (HP:0002671)2.00694540
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00329395
69Spontaneous hematomas (HP:0007420)1.98835436
70Deep philtrum (HP:0002002)1.98604708
71Autoimmune hemolytic anemia (HP:0001890)1.97485706
72Glomerulopathy (HP:0100820)1.95514492
73Lymphopenia (HP:0001888)1.92468040
74Gingival bleeding (HP:0000225)1.90935068
75Abnormality of iron homeostasis (HP:0011031)1.90303478
76Acne (HP:0001061)1.89955828
77IgA deficiency (HP:0002720)1.87923232
78Abnormality of cells of the lymphoid lineage (HP:0012140)1.87100577
79Polyneuropathy (HP:0001271)1.86403083
80Slow saccadic eye movements (HP:0000514)1.85047828
81Abnormality of the pericardium (HP:0001697)1.84901467
82Petechiae (HP:0000967)1.84582521
83Colitis (HP:0002583)1.84439389
843-Methylglutaconic aciduria (HP:0003535)1.84185155
85Purpura (HP:0000979)1.80983560
86Volvulus (HP:0002580)1.80063172
87Increased IgM level (HP:0003496)1.76464774
88IgM deficiency (HP:0002850)1.73324121
89Acute lymphatic leukemia (HP:0006721)1.70233471
90Gastrointestinal inflammation (HP:0004386)1.67967787
91Inflammation of the large intestine (HP:0002037)1.67865492
92Eczematoid dermatitis (HP:0000976)1.67803341
93Gastrointestinal infarctions (HP:0005244)1.64722733
94Chronic diarrhea (HP:0002028)1.61763569
95Prolonged bleeding time (HP:0003010)1.61555353
96Abnormality of oral frenula (HP:0000190)1.57389800
97Increased IgE level (HP:0003212)1.52631890
98Recurrent abscess formation (HP:0002722)1.51541899
99Epistaxis (HP:0000421)1.49168656
100Recurrent skin infections (HP:0001581)1.47687415
101Mitral regurgitation (HP:0001653)1.44903071
102Pruritus (HP:0000989)1.41655096
103Hemoptysis (HP:0002105)1.41425955
104Abnormal platelet volume (HP:0011876)1.38876904
105Aortic valve stenosis (HP:0001650)1.38334430
106Recurrent otitis media (HP:0000403)1.37130774
107Trigonocephaly (HP:0000243)1.33822965
108Abnormality of T cell physiology (HP:0011840)1.32897923
109Periodontitis (HP:0000704)1.32240412
110Dislocated radial head (HP:0003083)1.30768708
111Hypergammaglobulinemia (HP:0010702)1.28801532
112Ureteral stenosis (HP:0000071)1.28481226
113Chronic obstructive pulmonary disease (HP:0006510)1.28083733
114Obstructive lung disease (HP:0006536)1.28083733
115Mediastinal lymphadenopathy (HP:0100721)1.27569293
116Broad palm (HP:0001169)1.27144760
117Vasculitis (HP:0002633)1.25984301
118Abnormal foot bone ossification (HP:0010675)1.23963947
119Retrobulbar optic neuritis (HP:0100654)1.23410488
120Optic neuritis (HP:0100653)1.23410488
121Pulmonary embolism (HP:0002204)1.21950346
122Keratoconjunctivitis sicca (HP:0001097)1.21618459
123Abnormality of the radial head (HP:0003995)1.21104189
124Cutis marmorata (HP:0000965)1.21087885
125Long eyelashes (HP:0000527)1.20973486
126Sparse lateral eyebrow (HP:0005338)1.19333682
127Agammaglobulinemia (HP:0004432)1.17987339
128Hyperacusis (HP:0010780)1.17835620
129Chronic sinusitis (HP:0011109)1.17052283
130Ureteral obstruction (HP:0006000)1.15875106
131Orchitis (HP:0100796)1.14674457
132Recurrent bacterial skin infections (HP:0005406)1.14490515
133Amaurosis fugax (HP:0100576)1.13866509
134Chest pain (HP:0100749)1.13607793
135Bronchitis (HP:0012387)1.13186845
136Seborrheic dermatitis (HP:0001051)1.12587389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.33922125
2MAP4K15.12489956
3ITK3.56363238
4ZAP703.37892976
5GRK62.67844700
6MST42.53438547
7YES12.50468285
8STK102.44076420
9TAOK32.36128758
10CSK2.15190899
11SYK2.05533336
12PDGFRB2.05111766
13JAK32.00869685
14MAP3K71.90597530
15LCK1.89964473
16FGFR41.89729412
17TYK21.78826556
18MAPK71.75778601
19MAP3K111.75548870
20MAP3K101.73859374
21GRK71.68973841
22FGFR31.68527641
23NLK1.62986216
24HCK1.50949768
25SIK21.46478613
26PRKCQ1.41853236
27PKN21.36156845
28TEC1.35836559
29CDK121.32771644
30PRKCH1.32733534
31IKBKE1.25573027
32CLK11.21202568
33CSNK1A1L1.21152267
34MARK21.20219816
35TESK11.18380328
36MAP3K141.17544313
37FGFR21.14391848
38BTK1.12365398
39CAMKK21.12051700
40CSF1R1.08881082
41ADRBK21.08820401
42TLK11.04207846
43MAP3K121.00947615
44JAK11.00150676
45SCYL20.96250783
46CSNK1G30.95534183
47PRKD20.95180657
48MAP3K130.94074756
49LRRK20.91910606
50ERN10.91021895
51MATK0.84507799
52PIK3CG0.83040236
53MAPK120.82456162
54EEF2K0.80764743
55MAPK40.80437243
56MAP2K30.80320384
57MARK30.79767202
58TYRO30.79439470
59MAP3K30.78867370
60CSNK1G20.77942654
61CSNK1G10.76843053
62PIM10.76008028
63TAOK10.75514160
64TNK20.75040042
65BRD40.73306175
66CDK40.72270319
67HIPK20.70332366
68STK40.68322856
69JAK20.67157819
70INSR0.65570678
71MELK0.65437553
72CDK60.64850353
73FGR0.63615644
74BMPR20.62929333
75RPS6KA40.62461576
76FYN0.61272836
77TBK10.60785902
78TESK20.60278847
79RPS6KB20.59984339
80CDK30.58683991
81NEK20.57105775
82TGFBR20.56805992
83EPHB10.56513038
84KIT0.56177431
85NME20.54864739
86BCKDK0.54813275
87PTK60.54082112
88PIK3CA0.53336009
89TRIB30.53135267
90IRAK40.52907564
91PRKD10.50908018
92CAMK10.50035478
93LYN0.48317986
94FGFR10.48294682
95FES0.47959706
96MAPKAPK30.47435596
97SIK30.47210501
98ZAK0.46469334
99CAMKK10.44782813
100PASK0.44149554
101ALK0.43632150
102MAP2K60.43086987
103MAPKAPK20.42951207
104CDC70.42803696
105PRPF4B0.42713968
106DAPK10.39343397
107BLK0.38983210
108SGK30.36677110
109FLT30.36353638
110DAPK20.36001192
111MAP3K50.35923792
112VRK20.35707944
113CDK90.35250881
114TAOK20.35069795
115VRK10.33571320
116IKBKB0.33265938
117MAP4K20.32729824
118MAPK110.32554728
119MAPK30.32042435
120GRK50.32026864
121MKNK20.31544392
122KDR0.31065894
123CAMK40.30406205
124LIMK10.30323483
125DMPK0.29680157
126PDK10.29212814
127RET0.28979165
128MAP3K10.28558385
129RIPK40.27794600
130STK110.26870729
131NTRK20.26685442
132MAPK90.26665219
133ATR0.26423857
134DYRK1B0.25721175
135PRKCD0.25672808
136IGF1R0.25434068
137RPS6KA60.24842522
138RPS6KL10.24605491
139RPS6KC10.24605491
140WNK40.19206615
141ADRBK10.19069882
142NEK60.18740617
143IRAK10.17762419

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053407.44985909
2* T cell receptor signaling pathway_Homo sapiens_hsa046604.54564693
3Graft-versus-host disease_Homo sapiens_hsa053323.84338018
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.59171563
5Non-homologous end-joining_Homo sapiens_hsa034503.03660306
6* Antigen processing and presentation_Homo sapiens_hsa046122.85143910
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.76201872
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.33966735
9Measles_Homo sapiens_hsa051622.24077328
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.03736726
11Proteasome_Homo sapiens_hsa030501.81922021
12* Hematopoietic cell lineage_Homo sapiens_hsa046401.80481753
13Allograft rejection_Homo sapiens_hsa053301.69800298
14Acute myeloid leukemia_Homo sapiens_hsa052211.64176473
15Thyroid cancer_Homo sapiens_hsa052161.60945729
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.58291532
17Osteoclast differentiation_Homo sapiens_hsa043801.48679637
18Colorectal cancer_Homo sapiens_hsa052101.43765338
19Chemokine signaling pathway_Homo sapiens_hsa040621.39111488
20B cell receptor signaling pathway_Homo sapiens_hsa046621.37168236
21Leishmaniasis_Homo sapiens_hsa051401.32686705
22Viral myocarditis_Homo sapiens_hsa054161.31253808
23Herpes simplex infection_Homo sapiens_hsa051681.30593141
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28770861
25Chronic myeloid leukemia_Homo sapiens_hsa052201.25396735
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22857071
27HTLV-I infection_Homo sapiens_hsa051661.21894536
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19167726
29Endometrial cancer_Homo sapiens_hsa052131.19088703
30Hepatitis B_Homo sapiens_hsa051611.12186360
31Type I diabetes mellitus_Homo sapiens_hsa049401.11887995
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.11385293
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10277111
34FoxO signaling pathway_Homo sapiens_hsa040681.09920664
35Asthma_Homo sapiens_hsa053101.07269315
36* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93908472
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91177052
38African trypanosomiasis_Homo sapiens_hsa051430.89148798
39Prostate cancer_Homo sapiens_hsa052150.87480436
40Legionellosis_Homo sapiens_hsa051340.86910047
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85410939
42Platelet activation_Homo sapiens_hsa046110.84565629
43Toxoplasmosis_Homo sapiens_hsa051450.84216555
44Non-small cell lung cancer_Homo sapiens_hsa052230.83807758
45Autoimmune thyroid disease_Homo sapiens_hsa053200.83251296
46Pancreatic cancer_Homo sapiens_hsa052120.82982208
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81476728
48Influenza A_Homo sapiens_hsa051640.80467738
49Lysine degradation_Homo sapiens_hsa003100.80154972
50Apoptosis_Homo sapiens_hsa042100.74644997
51Spliceosome_Homo sapiens_hsa030400.74206561
52Adherens junction_Homo sapiens_hsa045200.72099798
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70007036
54Viral carcinogenesis_Homo sapiens_hsa052030.65621319
55Staphylococcus aureus infection_Homo sapiens_hsa051500.65330270
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65047175
57Shigellosis_Homo sapiens_hsa051310.64992812
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60160969
59Regulation of autophagy_Homo sapiens_hsa041400.59986139
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59513100
61TNF signaling pathway_Homo sapiens_hsa046680.59262769
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59139078
63Epstein-Barr virus infection_Homo sapiens_hsa051690.58261609
64mRNA surveillance pathway_Homo sapiens_hsa030150.58218102
65Prion diseases_Homo sapiens_hsa050200.56521068
66Phagosome_Homo sapiens_hsa041450.55135951
67Dorso-ventral axis formation_Homo sapiens_hsa043200.50800104
68Hepatitis C_Homo sapiens_hsa051600.49747665
69VEGF signaling pathway_Homo sapiens_hsa043700.49639846
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.49538986
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49214002
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48545065
73Small cell lung cancer_Homo sapiens_hsa052220.47592211
74Choline metabolism in cancer_Homo sapiens_hsa052310.47363020
75Circadian rhythm_Homo sapiens_hsa047100.46450675
76mTOR signaling pathway_Homo sapiens_hsa041500.45943423
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45090478
78RNA degradation_Homo sapiens_hsa030180.45017505
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44528950
80ErbB signaling pathway_Homo sapiens_hsa040120.44390272
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43544166
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43049790
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41644408
84Salmonella infection_Homo sapiens_hsa051320.40647202
85Endocytosis_Homo sapiens_hsa041440.39934032
86Rap1 signaling pathway_Homo sapiens_hsa040150.39722746
87p53 signaling pathway_Homo sapiens_hsa041150.38836849
88MicroRNAs in cancer_Homo sapiens_hsa052060.38362498
89Tuberculosis_Homo sapiens_hsa051520.37684192
90Cell cycle_Homo sapiens_hsa041100.37683730
91Malaria_Homo sapiens_hsa051440.37108932
92Pathways in cancer_Homo sapiens_hsa052000.36904868
93Prolactin signaling pathway_Homo sapiens_hsa049170.36643940
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36618802
95Wnt signaling pathway_Homo sapiens_hsa043100.35447123
96Oxidative phosphorylation_Homo sapiens_hsa001900.35232735
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35168089
98Mismatch repair_Homo sapiens_hsa034300.34506444
99Parkinsons disease_Homo sapiens_hsa050120.34468337
100Notch signaling pathway_Homo sapiens_hsa043300.34440398
101Ribosome_Homo sapiens_hsa030100.33463780
102DNA replication_Homo sapiens_hsa030300.33004851
103Long-term potentiation_Homo sapiens_hsa047200.32047656
104Basal cell carcinoma_Homo sapiens_hsa052170.31996517
105Insulin resistance_Homo sapiens_hsa049310.31940346
106MAPK signaling pathway_Homo sapiens_hsa040100.29904032
107Linoleic acid metabolism_Homo sapiens_hsa005910.29650037
108Renal cell carcinoma_Homo sapiens_hsa052110.29576689
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28955608
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.28885912
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.27162012
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26831152
113Systemic lupus erythematosus_Homo sapiens_hsa053220.26431188
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24503905
115Phototransduction_Homo sapiens_hsa047440.23533933
116Ras signaling pathway_Homo sapiens_hsa040140.22750177
117Inositol phosphate metabolism_Homo sapiens_hsa005620.22087963
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22061866
119Rheumatoid arthritis_Homo sapiens_hsa053230.21948223
120Pertussis_Homo sapiens_hsa051330.21321120
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.20406813
122Caffeine metabolism_Homo sapiens_hsa002320.16544279
123Lysosome_Homo sapiens_hsa041420.15121967
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14460297
125Alzheimers disease_Homo sapiens_hsa050100.13400410
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12348985
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11796150
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.10709354
129Nitrogen metabolism_Homo sapiens_hsa009100.06867313
130Collecting duct acid secretion_Homo sapiens_hsa049660.06700301
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.05954232
132Olfactory transduction_Homo sapiens_hsa047400.05053389
133Morphine addiction_Homo sapiens_hsa050320.04611606
134ABC transporters_Homo sapiens_hsa020100.04423581
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.01792466

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