CD86

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)5.68128615
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.67053110
3neutrophil activation involved in immune response (GO:0002283)5.51223255
4regulation of dendritic cell antigen processing and presentation (GO:0002604)5.33723054
5antigen processing and presentation of endogenous antigen (GO:0019883)5.08971595
6negative regulation of interleukin-12 production (GO:0032695)5.02463261
7positive regulation of interferon-alpha production (GO:0032727)5.00404851
8regulation of activation of Janus kinase activity (GO:0010533)4.95019196
9T-helper 1 type immune response (GO:0042088)4.83191463
10positive regulation of antigen processing and presentation (GO:0002579)4.80460040
11regulation of interferon-alpha production (GO:0032647)4.71770217
12positive regulation of interleukin-12 production (GO:0032735)4.64164763
13neutrophil activation (GO:0042119)4.41846511
14positive regulation of mast cell activation (GO:0033005)4.37759389
15detection of molecule of bacterial origin (GO:0032490)4.37678798
16granulocyte activation (GO:0036230)4.32657863
17type I interferon signaling pathway (GO:0060337)4.29261902
18cellular response to type I interferon (GO:0071357)4.29261902
19response to type I interferon (GO:0034340)4.23783557
20detection of other organism (GO:0098543)4.23664153
21positive regulation of alpha-beta T cell proliferation (GO:0046641)4.23001028
22response to peptidoglycan (GO:0032494)4.22218233
23negative regulation of interleukin-17 production (GO:0032700)4.19184514
24regulation of antigen processing and presentation (GO:0002577)4.18860365
25positive regulation of mast cell degranulation (GO:0043306)4.14967440
26positive regulation of mast cell activation involved in immune response (GO:0033008)4.14967440
27positive regulation of natural killer cell differentiation (GO:0032825)4.13391285
28positive regulation of monocyte chemotaxis (GO:0090026)4.12675759
29immunoglobulin mediated immune response (GO:0016064)4.04905897
30positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.03171416
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02940418
32negative regulation of cell killing (GO:0031342)4.02940418
33regulation of alpha-beta T cell proliferation (GO:0046640)3.97101809
34detection of external biotic stimulus (GO:0098581)3.92933237
35cellular extravasation (GO:0045123)3.92619686
36detection of bacterium (GO:0016045)3.90282031
37regulation of RIG-I signaling pathway (GO:0039535)3.88763686
38regulation of mast cell degranulation (GO:0043304)3.88370351
39interferon-gamma-mediated signaling pathway (GO:0060333)3.84497841
40positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.84132276
41regulation of interleukin-12 biosynthetic process (GO:0045075)3.81109845
42cellular response to zinc ion (GO:0071294)3.77337474
43* positive regulation of type 2 immune response (GO:0002830)3.76847441
44cellular response to exogenous dsRNA (GO:0071360)3.71431906
45regulation of mast cell activation (GO:0033003)3.68977670
46regulation of memory T cell differentiation (GO:0043380)3.67634927
47natural killer cell mediated cytotoxicity (GO:0042267)3.67039331
48natural killer cell mediated immunity (GO:0002228)3.67039331
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66870298
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66870298
51positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.65976801
52NIK/NF-kappaB signaling (GO:0038061)3.61997774
53* positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.60933054
54regulation of interferon-beta biosynthetic process (GO:0045357)3.59797782
55regulation of mast cell activation involved in immune response (GO:0033006)3.59234698
56regulation of interleukin-12 production (GO:0032655)3.58816646
57positive regulation by symbiont of host defense response (GO:0052509)3.57602573
58modulation by symbiont of host defense response (GO:0052031)3.57602573
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57602573
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57602573
61positive regulation by organism of defense response of other organism involved in symbiotic interact3.57602573
62modulation by symbiont of host immune response (GO:0052553)3.57602573
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.55610826
64detection of biotic stimulus (GO:0009595)3.55595723
65cellular response to interferon-beta (GO:0035458)3.54976248
66regulation of gamma-delta T cell activation (GO:0046643)3.54826286
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.54269389
68monocyte chemotaxis (GO:0002548)3.53206368
69regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.53107855
70* positive regulation of T-helper cell differentiation (GO:0045624)3.52752114
71response to muramyl dipeptide (GO:0032495)3.51996921
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.47588511
73eosinophil chemotaxis (GO:0048245)3.47292685
74macrophage activation (GO:0042116)3.46848188
75positive regulation of interferon-beta production (GO:0032728)3.45911907
76positive regulation of leukocyte degranulation (GO:0043302)3.43524492
77defense response to protozoan (GO:0042832)3.43040862
78negative thymic T cell selection (GO:0045060)3.42886653
79regulation of hypersensitivity (GO:0002883)3.42858224
80regulation of immunoglobulin secretion (GO:0051023)3.42755592
81regulation of T-helper 1 type immune response (GO:0002825)3.41482964
82regulation of myeloid leukocyte mediated immunity (GO:0002886)3.41073401
83regulation of interleukin-17 production (GO:0032660)3.39648576
84macrophage activation involved in immune response (GO:0002281)3.37799480
85positive regulation of interleukin-10 production (GO:0032733)3.36460702
86B cell mediated immunity (GO:0019724)3.36156722
87positive regulation of cellular amide metabolic process (GO:0034250)3.35005370
88respiratory burst (GO:0045730)3.33837911
89regulation of B cell receptor signaling pathway (GO:0050855)3.33826697
90dendritic cell chemotaxis (GO:0002407)3.32317701
91microglial cell activation (GO:0001774)3.31218229
92regulation of interferon-gamma biosynthetic process (GO:0045072)3.31036167
93regulation of leukocyte degranulation (GO:0043300)3.30296293
94response to host immune response (GO:0052572)3.29482057
95response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29482057
96T cell migration (GO:0072678)3.28284854
97cellular response to thyroid hormone stimulus (GO:0097067)3.27202790
98negative regulation of viral genome replication (GO:0045071)3.26887168
99positive regulation of T cell cytokine production (GO:0002726)3.26689608
100positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.22780479
101regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.21491374
102regulation of monocyte chemotaxis (GO:0090025)3.20985947
103* myeloid dendritic cell differentiation (GO:0043011)3.17210957
104leukocyte mediated cytotoxicity (GO:0001909)3.17000421
105negative T cell selection (GO:0043383)3.15465732
106positive regulation of interleukin-17 production (GO:0032740)3.14941004
107positive regulation of gamma-delta T cell activation (GO:0046645)3.14495114
108positive regulation of response to biotic stimulus (GO:0002833)3.13144640
109regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13027892
110response to protozoan (GO:0001562)3.12010271
111positive regulation of T-helper 1 type immune response (GO:0002827)3.11688701
112* regulation of T-helper cell differentiation (GO:0045622)3.11234838
113* regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.10674969
114regulation of mononuclear cell migration (GO:0071675)3.08262699
115response to interferon-alpha (GO:0035455)3.08249838
116* response to interferon-gamma (GO:0034341)3.07369074
117production of molecular mediator involved in inflammatory response (GO:0002532)3.06979819
118myeloid cell activation involved in immune response (GO:0002275)3.06892910
119cellular response to interferon-gamma (GO:0071346)3.06586168
120natural killer cell differentiation (GO:0001779)3.06468988
121adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.05222950
122eosinophil migration (GO:0072677)3.04900104
123dendritic cell migration (GO:0036336)3.04544114
124* myeloid dendritic cell activation (GO:0001773)3.04207787
125positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.03515245
126positive regulation of macrophage cytokine production (GO:0060907)3.02937104
127glycosphingolipid catabolic process (GO:0046479)3.02675537
128response to interferon-beta (GO:0035456)3.02355537
129* positive regulation of interleukin-2 production (GO:0032743)3.01250276
130* positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.01150760
131positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00856920
132positive regulation of B cell differentiation (GO:0045579)3.00369314
133positive regulation of humoral immune response (GO:0002922)2.99720859
134lymphocyte chemotaxis (GO:0048247)2.96844296
135response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93244583
136response to host (GO:0075136)2.93244583
137response to host defenses (GO:0052200)2.93244583
138regulation of macrophage chemotaxis (GO:0010758)2.91778945
139negative regulation of T cell mediated immunity (GO:0002710)2.88902868
140germinal center formation (GO:0002467)2.88217650
141positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87259306
142regulation of inflammatory response to antigenic stimulus (GO:0002861)2.86113630
143negative regulation of cytokine production involved in immune response (GO:0002719)2.82132061
144B cell receptor signaling pathway (GO:0050853)2.81707507
145positive regulation of immunoglobulin mediated immune response (GO:0002891)2.80454701
146positive regulation of B cell mediated immunity (GO:0002714)2.80454701
147amino sugar catabolic process (GO:0046348)2.79306185

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.28435938
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.45230411
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.43941871
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.40842830
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.32398258
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.19666358
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.57520008
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72203531
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.39902670
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.30653819
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.26144334
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.16589189
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.12100630
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06547469
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.95803732
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.85649594
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.34419313
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.34128236
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18540807
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01543710
21* SPI1_23547873_ChIP-Seq_NB4_Human1.98407107
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96959502
23MYB_26560356_Chip-Seq_TH2_Human1.90893021
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.85169051
25RUNX_20019798_ChIP-Seq_JUKART_Human1.81187114
26VDR_24787735_ChIP-Seq_THP-1_Human1.78071566
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68530073
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62585434
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62504760
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61784613
31MAF_26560356_Chip-Seq_TH1_Human1.60983063
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57093588
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56465583
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54795157
35PU_27001747_Chip-Seq_BMDM_Mouse1.52147582
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51983504
37SCL_19346495_ChIP-Seq_HPC-7_Human1.50970945
38MYC_22102868_ChIP-Seq_BL_Human1.49760728
39CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48347782
40SPI1_23127762_ChIP-Seq_K562_Human1.46294978
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45835978
42* MYB_26560356_Chip-Seq_TH1_Human1.44491405
43VDR_24763502_ChIP-Seq_THP-1_Human1.40769896
44GATA3_26560356_Chip-Seq_TH2_Human1.35773610
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32656463
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.32348728
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27384860
48* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26590386
49PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25414978
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.25198856
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23157005
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22204307
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21119881
54GATA3_27048872_Chip-Seq_THYMUS_Human1.19805829
55* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18735181
56GATA1_22025678_ChIP-Seq_K562_Human1.17029052
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15202239
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14106477
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13517853
60EGR1_19032775_ChIP-ChIP_M12_Human1.12642388
61TFEB_21752829_ChIP-Seq_HELA_Human1.12259693
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11980009
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08716470
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01116300
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00940116
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00638254
67GATA2_21666600_ChIP-Seq_HMVEC_Human0.99094646
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98533564
69IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98168364
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95716543
71KDM2B_26808549_Chip-Seq_DND41_Human0.95328230
72STAT1_20625510_ChIP-Seq_HELA_Human0.95056494
73GATA1_19941826_ChIP-Seq_K562_Human0.94292316
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90194682
75SMRT_27268052_Chip-Seq_Bcells_Human0.89851561
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88825101
77CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87395036
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87259729
79LXR_22292898_ChIP-Seq_THP-1_Human0.86917043
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86074826
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86025226
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85815635
83VDR_21846776_ChIP-Seq_THP-1_Human0.84826515
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83949761
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.83586518
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81671268
87MAF_26560356_Chip-Seq_TH2_Human0.80066133
88BCL6_27268052_Chip-Seq_Bcells_Human0.79466160
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77123888
90SPI1_20517297_ChIP-Seq_HL60_Human0.73638277
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72359995
92NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72359995
93GATA2_19941826_ChIP-Seq_K562_Human0.72292675
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71400049
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.70197403
96ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70018917
97UTX_26944678_Chip-Seq_JUKART_Human0.69440862
98BCOR_27268052_Chip-Seq_Bcells_Human0.69062594
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.68328267
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.66225477
101GATA1_19941827_ChIP-Seq_MEL86_Mouse0.66177106
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.66156103
103SOX2_20726797_ChIP-Seq_SW620_Human0.64306019
104PU1_27457419_Chip-Seq_LIVER_Mouse0.63371038
105FLI1_27457419_Chip-Seq_LIVER_Mouse0.61467344
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60743712
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.60608364
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.58599760
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55047132
110KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.54389529
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.54352116
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.54352116
113TCF7_22412390_ChIP-Seq_EML_Mouse0.54072207
114NMYC_18555785_Chip-Seq_ESCs_Mouse0.54017266
115STAT3_18555785_Chip-Seq_ESCs_Mouse0.52678346
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.52462038
117CJUN_26792858_Chip-Seq_BT549_Human0.51746080
118GATA3_26560356_Chip-Seq_TH1_Human0.51405733
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.50706701
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.50471805
121CMYC_18555785_Chip-Seq_ESCs_Mouse0.49799164
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.49540991
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.49010229
124RUNX1_27457419_Chip-Seq_LIVER_Mouse0.48995120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.24575205
2MP0002148_abnormal_hypersensitivity_rea4.30285694
3MP0000685_abnormal_immune_system3.99334671
4MP0005671_abnormal_response_to3.82947191
5MP0009785_altered_susceptibility_to3.82353639
6MP0001790_abnormal_immune_system3.55330075
7MP0005387_immune_system_phenotype3.55330075
8MP0003436_decreased_susceptibility_to3.51104167
9* MP0005000_abnormal_immune_tolerance3.35293149
10MP0005025_abnormal_response_to3.03843603
11* MP0001800_abnormal_humoral_immune2.92652290
12MP0006082_CNS_inflammation2.92561555
13MP0002419_abnormal_innate_immunity2.91508063
14* MP0002452_abnormal_antigen_presenting2.86311595
15MP0004510_myositis2.86268714
16* MP0002723_abnormal_immune_serum2.76590916
17MP0003724_increased_susceptibility_to2.55735165
18* MP0001819_abnormal_immune_cell2.47480767
19* MP0002420_abnormal_adaptive_immunity2.41875023
20MP0002163_abnormal_gland_morphology2.36873520
21MP0005310_abnormal_salivary_gland2.28033522
22MP0001853_heart_inflammation2.24269010
23MP0001348_abnormal_lacrimal_gland2.20806231
24MP0003303_peritoneal_inflammation2.10818392
25MP0002166_altered_tumor_susceptibility2.09341358
26MP0002006_tumorigenesis2.05818338
27MP0002138_abnormal_hepatobiliary_system1.96824770
28* MP0000716_abnormal_immune_system1.83110860
29MP0002405_respiratory_system_inflammati1.82078311
30MP0005058_abnormal_lysosome_morphology1.81140061
31MP0001845_abnormal_inflammatory_respons1.79390926
32MP0005464_abnormal_platelet_physiology1.78156286
33MP0001533_abnormal_skeleton_physiology1.77148088
34MP0009764_decreased_sensitivity_to1.76031944
35* MP0002398_abnormal_bone_marrow1.73348009
36MP0009333_abnormal_splenocyte_physiolog1.67846830
37MP0005451_abnormal_body_composition1.64377366
38MP0003191_abnormal_cellular_cholesterol1.62347431
39MP0010155_abnormal_intestine_physiology1.58765006
40* MP0008469_abnormal_protein_level1.51046582
41MP0004947_skin_inflammation1.48602674
42MP0001346_abnormal_lacrimal_gland1.47912996
43MP0002254_reproductive_system_inflammat1.46526895
44* MP0002429_abnormal_blood_cell1.40828516
45MP0003448_altered_tumor_morphology1.40526145
46MP0005379_endocrine/exocrine_gland_phen1.36876448
47MP0002277_abnormal_respiratory_mucosa1.35692656
48MP0003806_abnormal_nucleotide_metabolis1.30936243
49MP0003075_altered_response_to1.30130893
50* MP0000689_abnormal_spleen_morphology1.28296111
51MP0008260_abnormal_autophagy1.28111876
52MP0009840_abnormal_foam_cell1.26615692
53MP0002722_abnormal_immune_system1.25581157
54MP0003763_abnormal_thymus_physiology1.20653755
55MP0008004_abnormal_stomach_pH1.17458127
56MP0002139_abnormal_hepatobiliary_system1.14447005
57MP0000569_abnormal_digit_pigmentation1.11980216
58MP0000858_altered_metastatic_potential1.06199019
59MP0000343_altered_response_to1.05041535
60MP0002998_abnormal_bone_remodeling1.04805963
61MP0003172_abnormal_lysosome_physiology1.03521102
62MP0005397_hematopoietic_system_phenotyp1.00229102
63MP0001545_abnormal_hematopoietic_system1.00229102
64MP0004782_abnormal_surfactant_physiolog0.97913485
65MP0000465_gastrointestinal_hemorrhage0.97200436
66MP0009763_increased_sensitivity_to0.90826809
67MP0003656_abnormal_erythrocyte_physiolo0.90567267
68MP0003690_abnormal_glial_cell0.88848418
69* MP0000920_abnormal_myelination0.84545649
70MP0002876_abnormal_thyroid_physiology0.84519763
71MP0008057_abnormal_DNA_replication0.83808676
72MP0005174_abnormal_tail_pigmentation0.79966792
73MP0001851_eye_inflammation0.79724675
74MP0005166_decreased_susceptibility_to0.79608477
75MP0001663_abnormal_digestive_system0.78186360
76MP0005390_skeleton_phenotype0.77607685
77MP0010307_abnormal_tumor_latency0.74933481
78MP0000249_abnormal_blood_vessel0.73986614
79MP0003186_abnormal_redox_activity0.73852992
80MP0005167_abnormal_blood-brain_barrier0.70534238
81MP0005076_abnormal_cell_differentiation0.70208026
82MP0002332_abnormal_exercise_endurance0.69497723
83MP0003795_abnormal_bone_structure0.68702183
84MP0001873_stomach_inflammation0.68491931
85MP0003183_abnormal_peptide_metabolism0.68428767
86MP0000703_abnormal_thymus_morphology0.68224928
87MP0002933_joint_inflammation0.67438904
88MP0003091_abnormal_cell_migration0.64966326
89MP0002877_abnormal_melanocyte_morpholog0.64827124
90MP0005165_increased_susceptibility_to0.64252359
91MP0003329_amyloid_beta_deposits0.64042451
92MP0003300_gastrointestinal_ulcer0.63852977
93MP0006054_spinal_hemorrhage0.63243227
94MP0004808_abnormal_hematopoietic_stem0.62234301
95MP0002132_abnormal_respiratory_system0.62153956
96MP0005164_abnormal_response_to0.61900938
97MP0008874_decreased_physiological_sensi0.61619303
98MP0009278_abnormal_bone_marrow0.60923834
99MP0003195_calcinosis0.60627563
100MP0002693_abnormal_pancreas_physiology0.59793710
101MP0003828_pulmonary_edema0.59717957
102MP0000604_amyloidosis0.59466442
103MP0002136_abnormal_kidney_physiology0.59089737
104MP0000371_diluted_coat_color0.58928500
105MP0002009_preneoplasia0.58559379
106MP0003045_fibrosis0.58380429
107MP0005647_abnormal_sex_gland0.57944720
108MP0000767_abnormal_smooth_muscle0.56752537
109MP0003866_abnormal_defecation0.56135169
110MP0000015_abnormal_ear_pigmentation0.53712271
111MP0000609_abnormal_liver_physiology0.53040563
112MP0004883_abnormal_blood_vessel0.52697324
113MP0003453_abnormal_keratinocyte_physiol0.52602078
114MP0001881_abnormal_mammary_gland0.48704573
115MP0009765_abnormal_xenobiotic_induced0.48049387
116MP0000627_abnormal_mammary_gland0.46192389
117MP0001915_intracranial_hemorrhage0.46092551
118MP0002396_abnormal_hematopoietic_system0.44039214
119MP0000490_abnormal_crypts_of0.40906116
120MP0005584_abnormal_enzyme/coenzyme_acti0.40225057

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.55647901
2Recurrent bacterial skin infections (HP:0005406)6.29382942
3Eczematoid dermatitis (HP:0000976)6.23045787
4Increased IgM level (HP:0003496)5.25369749
5Optic neuritis (HP:0100653)5.19873100
6Retrobulbar optic neuritis (HP:0100654)5.19873100
7Systemic lupus erythematosus (HP:0002725)4.91387696
8Orchitis (HP:0100796)4.89892644
9Myositis (HP:0100614)4.86653486
10Autoimmune thrombocytopenia (HP:0001973)4.76800518
11Recurrent gram-negative bacterial infections (HP:0005420)4.76357287
12Mediastinal lymphadenopathy (HP:0100721)4.57301703
13Elevated erythrocyte sedimentation rate (HP:0003565)4.54816575
14Vasculitis (HP:0002633)4.25475716
15Abnormality of macrophages (HP:0004311)4.16064480
16Recurrent skin infections (HP:0001581)4.11133456
17Recurrent fungal infections (HP:0002841)4.01640021
18Basal ganglia calcification (HP:0002135)3.81037444
19Recurrent viral infections (HP:0004429)3.69993323
20Gastrointestinal infarctions (HP:0005244)3.56887459
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.54504127
22Disinhibition (HP:0000734)3.53058153
23Gingivitis (HP:0000230)3.52312461
24Loss of speech (HP:0002371)3.50593950
25Chronic otitis media (HP:0000389)3.48802631
26Hypergammaglobulinemia (HP:0010702)3.39089376
27Recurrent cutaneous fungal infections (HP:0011370)3.35696348
28Chronic mucocutaneous candidiasis (HP:0002728)3.35696348
29Pulmonary infiltrates (HP:0002113)3.34841003
30Agammaglobulinemia (HP:0004432)3.32954094
31Obstructive lung disease (HP:0006536)3.28854152
32Chronic obstructive pulmonary disease (HP:0006510)3.28854152
33Meningitis (HP:0001287)3.22749657
34Arterial thrombosis (HP:0004420)3.22100654
35Glomerulonephritis (HP:0000099)3.12725426
36Keratoconjunctivitis sicca (HP:0001097)3.10944334
37Cellulitis (HP:0100658)3.06901498
38Recurrent pneumonia (HP:0006532)3.01582427
39Amyloidosis (HP:0011034)3.00248841
40Periodontitis (HP:0000704)2.99833201
41Vacuolated lymphocytes (HP:0001922)2.99497475
42Stomatitis (HP:0010280)2.98871458
43Thick nail (HP:0001805)2.95967901
44Pustule (HP:0200039)2.93620925
45Mutism (HP:0002300)2.93531383
46Keratoconjunctivitis (HP:0001096)2.87873283
47Eosinophilia (HP:0001880)2.85035862
48Recurrent lower respiratory tract infections (HP:0002783)2.83023015
49T lymphocytopenia (HP:0005403)2.77027115
50Abnormality of polysaccharide metabolism (HP:0011012)2.75665962
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75665962
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75665962
53Colitis (HP:0002583)2.75144442
54Abnormality of T cell number (HP:0011839)2.71971780
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.70205582
56Osteolytic defects of the hand bones (HP:0009699)2.70205582
57Autoimmune hemolytic anemia (HP:0001890)2.69232079
58Leukocytosis (HP:0001974)2.67840880
59Urinary glycosaminoglycan excretion (HP:0003541)2.65587532
60Mucopolysacchariduria (HP:0008155)2.65587532
61Hemoptysis (HP:0002105)2.64377253
62Recurrent bronchitis (HP:0002837)2.63766332
63Encephalitis (HP:0002383)2.61935946
64Interstitial pulmonary disease (HP:0006530)2.59062823
65Osteomyelitis (HP:0002754)2.58646908
66Myocardial infarction (HP:0001658)2.55789712
67Abnormality of the prostate (HP:0008775)2.54581737
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.54337353
69Urticaria (HP:0001025)2.53195411
70Axonal loss (HP:0003447)2.50008125
71Prostate neoplasm (HP:0100787)2.49388466
72Joint swelling (HP:0001386)2.48075519
73Abnormality of T cell physiology (HP:0011840)2.47221066
74Granulocytopenia (HP:0001913)2.46033155
75IgA deficiency (HP:0002720)2.45651983
76Increased cerebral lipofuscin (HP:0011813)2.41046626
77Panhypogammaglobulinemia (HP:0003139)2.40488987
78Polyneuropathy (HP:0001271)2.39578679
79Abnormality of glycolipid metabolism (HP:0010969)2.38798526
80Abnormality of liposaccharide metabolism (HP:0010968)2.38798526
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.38798526
82Inflammation of the large intestine (HP:0002037)2.38367808
83Tetraparesis (HP:0002273)2.36995334
84Gingival bleeding (HP:0000225)2.35958970
85Porencephaly (HP:0002132)2.32773978
86Gastrointestinal stroma tumor (HP:0100723)2.32592225
87IgG deficiency (HP:0004315)2.32298401
88Abnormality of eosinophils (HP:0001879)2.31931662
89Pulmonary embolism (HP:0002204)2.31448446
90Increased serum ferritin (HP:0003281)2.28741452
91Abnormality of the pleura (HP:0002103)2.28443917
92Abnormality of T cells (HP:0002843)2.27283959
93Agnosia (HP:0010524)2.26414620
94Chronic sinusitis (HP:0011109)2.26129267
95Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25861629
96Chronic diarrhea (HP:0002028)2.25502465
97Nasal polyposis (HP:0100582)2.25356474
98Restrictive lung disease (HP:0002091)2.24389793
99Petechiae (HP:0000967)2.22463130
100Anorexia (HP:0002039)2.22181821
101Gangrene (HP:0100758)2.21944512
102Epistaxis (HP:0000421)2.19788848
103Hepatosplenomegaly (HP:0001433)2.19779928
104Spontaneous hematomas (HP:0007420)2.19672048
105Nephritis (HP:0000123)2.19588571
106Abnormality of cells of the lymphoid lineage (HP:0012140)2.19016405
107Arthralgia (HP:0002829)2.17386413
108Thrombocytosis (HP:0001894)2.16964649
109Amaurosis fugax (HP:0100576)2.16584103
110Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16364683
111Neurofibrillary tangles (HP:0002185)2.16198070
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15982227
113Gastrointestinal inflammation (HP:0004386)2.15787366
114Neuronal loss in central nervous system (HP:0002529)2.14049765
115Purpura (HP:0000979)2.11469356
116Hypochromic anemia (HP:0001931)2.11042648
117Thyroiditis (HP:0100646)2.10395041
118Abnormality of complement system (HP:0005339)2.08553174
119Glomerulopathy (HP:0100820)2.07821651
120Dysostosis multiplex (HP:0000943)2.06675068
121Chest pain (HP:0100749)2.06079974
122Diminished motivation (HP:0000745)2.06000821
123Apathy (HP:0000741)2.05083115
124Memory impairment (HP:0002354)2.03395436
125Increased IgE level (HP:0003212)2.02740034
126Vertebral compression fractures (HP:0002953)2.02688338
127Progressive neurologic deterioration (HP:0002344)2.02605080
128Abnormality of the pericardium (HP:0001697)1.99791123
129Premature loss of primary teeth (HP:0006323)1.99423280
130Upper motor neuron abnormality (HP:0002127)1.99192821
131Hematochezia (HP:0002573)1.98372545
132Inappropriate behavior (HP:0000719)1.95380685
133Vertigo (HP:0002321)1.94590647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.85014698
2BLK3.66777373
3TBK13.60020274
4TYK23.45909931
5IRAK43.35683295
6IKBKB3.34496964
7RIPK43.08471305
8IKBKE2.93768284
9JAK32.71363496
10MAP3K132.61817054
11MAP4K12.36391666
12IRAK32.28792353
13JAK12.28309333
14BMPR22.26927802
15PRPF4B2.18871548
16PIM22.11996207
17CHUK2.06655829
18PBK1.99628676
19TXK1.93410017
20MST41.82633234
21SYK1.77349793
22KIT1.73131423
23EPHB11.61733053
24BTK1.53836821
25TGFBR21.52813701
26CSF1R1.52729445
27HCK1.39910086
28ZAP701.36546781
29TAOK21.35751711
30GRK71.33837933
31MAP3K31.33279867
32TEC1.33160763
33ARAF1.30928074
34EIF2AK21.30172809
35NME21.29544041
36PIM11.25275633
37LYN1.25075965
38CSK1.24337667
39NEK91.24334814
40JAK21.09098240
41BCR1.07451106
42TAOK11.05814848
43LCK1.04176980
44FGFR41.02556904
45CDC42BPA1.01717063
46EPHA31.00359032
47TNK21.00156750
48FGFR30.99483273
49ITK0.94423899
50CAMKK20.91993682
51DDR20.91005258
52ADRBK20.90369597
53YES10.88714430
54IRAK10.84827443
55PKN10.83468172
56SIK30.83324567
57PRKCQ0.82908393
58MATK0.81725570
59ABL20.80324492
60TRPM70.78136660
61PDK10.76855164
62PRKCD0.75637975
63STK40.74375504
64STK100.73999780
65ERN10.71074213
66TAOK30.70534213
67PDPK10.70062572
68TESK20.66882611
69STK240.66815669
70CDK190.66280038
71BMX0.66144667
72CAMK1D0.66078177
73MOS0.65916586
74FES0.65406840
75MAPK70.65393443
76MAPKAPK20.60461382
77ABL10.59469932
78MAPK120.56733648
79MARK30.56291034
80RPS6KA40.54071936
81FYN0.53947832
82IRAK20.53561565
83BMPR1B0.53161078
84SIK20.50408020
85PDK20.49894689
86RAF10.48538751
87CLK10.48160372
88TESK10.46489534
89RPS6KC10.42292381
90RPS6KL10.42292381
91FGR0.42222589
92EGFR0.41912384
93STK30.38765152
94KSR20.37274801
95DAPK20.36782674
96ERBB30.36419738
97CDK40.36308805
98PTK60.36280416
99RPS6KA50.36140984
100NLK0.35865761
101GRK60.35439488
102LRRK20.34293604
103MAPK40.33937967
104NUAK10.32950663
105PIK3CG0.32472525
106MARK20.29973591
107RIPK10.29875660
108HIPK20.28199677
109IGF1R0.26419432
110MAP3K50.24976783
111WNK10.24791164
112MAP2K30.24331683
113CAMKK10.23144595
114RPS6KA20.21762634
115MAP3K80.20940763
116FLT30.18459723
117RPS6KA10.18379163
118INSR0.18041964
119PRKCE0.17455860
120ACVR1B0.17320142
121MAP3K110.16508517
122CDK60.16408235
123RPS6KA60.14215506
124MAP2K60.14092521
125MAP3K120.13619047
126MAP3K10.13298070
127DYRK1B0.13163918
128MST1R0.12992426

Predicted pathways (KEGG)

RankGene SetZ-score
1* Allograft rejection_Homo sapiens_hsa053303.66677095
2* Graft-versus-host disease_Homo sapiens_hsa053323.14721535
3Leishmaniasis_Homo sapiens_hsa051403.04059094
4* Intestinal immune network for IgA production_Homo sapiens_hsa046722.90263368
5* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.85398596
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.81652142
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.76964129
8Staphylococcus aureus infection_Homo sapiens_hsa051502.60209304
9Measles_Homo sapiens_hsa051622.48299384
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.45413169
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.30370147
12Osteoclast differentiation_Homo sapiens_hsa043802.27046164
13Pertussis_Homo sapiens_hsa051332.20147321
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15534118
15Primary immunodeficiency_Homo sapiens_hsa053402.09324607
16* Autoimmune thyroid disease_Homo sapiens_hsa053202.08610808
17Legionellosis_Homo sapiens_hsa051342.07835238
18* Type I diabetes mellitus_Homo sapiens_hsa049402.06803755
19Influenza A_Homo sapiens_hsa051642.05485499
20Tuberculosis_Homo sapiens_hsa051521.97100708
21Antigen processing and presentation_Homo sapiens_hsa046121.90654701
22B cell receptor signaling pathway_Homo sapiens_hsa046621.88285992
23Malaria_Homo sapiens_hsa051441.86106843
24Toxoplasmosis_Homo sapiens_hsa051451.84891634
25Herpes simplex infection_Homo sapiens_hsa051681.84042571
26* Rheumatoid arthritis_Homo sapiens_hsa053231.82796798
27TNF signaling pathway_Homo sapiens_hsa046681.79235985
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.79177436
29African trypanosomiasis_Homo sapiens_hsa051431.78795795
30Asthma_Homo sapiens_hsa053101.71083614
31Chemokine signaling pathway_Homo sapiens_hsa040621.69004923
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57369789
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.55124179
34Apoptosis_Homo sapiens_hsa042101.50120378
35Salmonella infection_Homo sapiens_hsa051321.40702610
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37773018
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34946752
38Lysosome_Homo sapiens_hsa041421.32614772
39* Viral myocarditis_Homo sapiens_hsa054161.32566544
40Shigellosis_Homo sapiens_hsa051311.30450979
41Hematopoietic cell lineage_Homo sapiens_hsa046401.18098740
42Phagosome_Homo sapiens_hsa041451.17472087
43Hepatitis B_Homo sapiens_hsa051611.13483290
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08078842
45Other glycan degradation_Homo sapiens_hsa005111.01747778
46Hepatitis C_Homo sapiens_hsa051601.01630925
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96887147
48T cell receptor signaling pathway_Homo sapiens_hsa046600.96847450
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92805241
50Prion diseases_Homo sapiens_hsa050200.84059604
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.81552992
52Prolactin signaling pathway_Homo sapiens_hsa049170.74492446
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73264281
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72306470
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71596800
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.70295817
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69950859
58Acute myeloid leukemia_Homo sapiens_hsa052210.69252588
59* Systemic lupus erythematosus_Homo sapiens_hsa053220.69069384
60Epstein-Barr virus infection_Homo sapiens_hsa051690.65298737
61Amoebiasis_Homo sapiens_hsa051460.60345222
62Complement and coagulation cascades_Homo sapiens_hsa046100.58475813
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54446749
64Chronic myeloid leukemia_Homo sapiens_hsa052200.54190436
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54059371
66* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53597345
67Pancreatic cancer_Homo sapiens_hsa052120.52682601
68Platelet activation_Homo sapiens_hsa046110.49564128
69Proteasome_Homo sapiens_hsa030500.45093816
70Viral carcinogenesis_Homo sapiens_hsa052030.44176767
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.42453659
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.37259354
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35099648
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34918109
75Bladder cancer_Homo sapiens_hsa052190.32621456
76Sphingolipid metabolism_Homo sapiens_hsa006000.31590291
77Non-small cell lung cancer_Homo sapiens_hsa052230.31520876
78HTLV-I infection_Homo sapiens_hsa051660.31329266
79Small cell lung cancer_Homo sapiens_hsa052220.31040309
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27944122
81p53 signaling pathway_Homo sapiens_hsa041150.27747434
82Renal cell carcinoma_Homo sapiens_hsa052110.26177627
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25159988
84Vibrio cholerae infection_Homo sapiens_hsa051100.21844447
85* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21842533
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.21419726
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.20739435
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18245522
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17945520
90Galactose metabolism_Homo sapiens_hsa000520.17883464
91MAPK signaling pathway_Homo sapiens_hsa040100.17864904
92HIF-1 signaling pathway_Homo sapiens_hsa040660.17541289
93GnRH signaling pathway_Homo sapiens_hsa049120.17035291
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16375933
95Collecting duct acid secretion_Homo sapiens_hsa049660.16072539
96Endocytosis_Homo sapiens_hsa041440.15948960
97Caffeine metabolism_Homo sapiens_hsa002320.15301967
98Phenylalanine metabolism_Homo sapiens_hsa003600.14161912
99Arachidonic acid metabolism_Homo sapiens_hsa005900.14075912
100VEGF signaling pathway_Homo sapiens_hsa043700.13792560
101Renin-angiotensin system_Homo sapiens_hsa046140.11674871
102Notch signaling pathway_Homo sapiens_hsa043300.11484756
103Type II diabetes mellitus_Homo sapiens_hsa049300.10729400
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10485440
105FoxO signaling pathway_Homo sapiens_hsa040680.10296021
106Proteoglycans in cancer_Homo sapiens_hsa052050.10059298
107PPAR signaling pathway_Homo sapiens_hsa033200.09519922
108Ether lipid metabolism_Homo sapiens_hsa005650.08889888
109Dorso-ventral axis formation_Homo sapiens_hsa043200.06526085
110Mineral absorption_Homo sapiens_hsa049780.06309127
111Insulin resistance_Homo sapiens_hsa049310.06262012
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.05629674
113Prostate cancer_Homo sapiens_hsa052150.04317999
114Ras signaling pathway_Homo sapiens_hsa040140.04317766
115mTOR signaling pathway_Homo sapiens_hsa041500.02851179

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