CD84

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.69612846
2positive regulation by symbiont of host defense response (GO:0052509)5.40830427
3modulation by symbiont of host defense response (GO:0052031)5.40830427
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.40830427
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.40830427
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.40830427
7modulation by symbiont of host immune response (GO:0052553)5.40830427
8regulation of interferon-beta biosynthetic process (GO:0045357)4.57520151
9neutrophil activation involved in immune response (GO:0002283)4.22175087
10immunoglobulin mediated immune response (GO:0016064)4.13057780
11regulation of B cell receptor signaling pathway (GO:0050855)4.08281622
12oligosaccharide catabolic process (GO:0009313)3.92811750
13macrophage activation involved in immune response (GO:0002281)3.88305563
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.82323764
15positive regulation of gamma-delta T cell activation (GO:0046645)3.75628661
16positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.73395042
17glycolipid catabolic process (GO:0019377)3.66687297
18positive regulation of interferon-alpha production (GO:0032727)3.56059295
19positive regulation of mast cell degranulation (GO:0043306)3.55864277
20positive regulation of mast cell activation involved in immune response (GO:0033008)3.55864277
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46798908
22response to host immune response (GO:0052572)3.46798908
23regulation of interferon-alpha production (GO:0032647)3.39159170
24pinocytosis (GO:0006907)3.35744959
25ceramide catabolic process (GO:0046514)3.35062603
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.33968287
27positive regulation of interferon-beta production (GO:0032728)3.33437317
28microglial cell activation (GO:0001774)3.32582193
29positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.31125171
30detection of other organism (GO:0098543)3.30916929
31positive regulation of B cell differentiation (GO:0045579)3.21226492
32detection of molecule of bacterial origin (GO:0032490)3.20783897
33B cell mediated immunity (GO:0019724)3.19426509
34respiratory burst (GO:0045730)3.18949571
35natural killer cell mediated immunity (GO:0002228)3.16316564
36natural killer cell mediated cytotoxicity (GO:0042267)3.16316564
37positive regulation of antigen processing and presentation (GO:0002579)3.16280054
38myeloid cell activation involved in immune response (GO:0002275)3.14903358
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.14838003
40negative regulation of cell killing (GO:0031342)3.14838003
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.13134579
42response to host (GO:0075136)3.13134579
43response to host defenses (GO:0052200)3.13134579
44regulation of T cell tolerance induction (GO:0002664)3.12748567
45regulation of mononuclear cell migration (GO:0071675)3.12164796
46response to peptidoglycan (GO:0032494)3.09064683
47positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.07857707
48positive regulation of leukocyte degranulation (GO:0043302)3.07391862
49T-helper 1 type immune response (GO:0042088)3.06953791
50myeloid dendritic cell differentiation (GO:0043011)3.06638678
51lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06240298
52regulation of cholesterol storage (GO:0010885)3.05352855
53positive regulation of monocyte chemotaxis (GO:0090026)3.04837679
54regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03683464
55regulation of leukocyte degranulation (GO:0043300)3.03459859
56production of molecular mediator involved in inflammatory response (GO:0002532)3.02567578
57regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.01922154
58N-acetylneuraminate metabolic process (GO:0006054)3.01483618
59regulation of hypersensitivity (GO:0002883)3.01395336
60response to muramyl dipeptide (GO:0032495)3.00546378
61detection of external biotic stimulus (GO:0098581)3.00336111
62detection of bacterium (GO:0016045)2.99396914
63regulation of tolerance induction (GO:0002643)2.98271269
64germinal center formation (GO:0002467)2.97826155
65negative regulation of T cell mediated immunity (GO:0002710)2.95543831
66neutrophil activation (GO:0042119)2.94703693
67NIK/NF-kappaB signaling (GO:0038061)2.93717370
68negative thymic T cell selection (GO:0045060)2.92749185
69granulocyte activation (GO:0036230)2.90955536
70regulation of interferon-beta production (GO:0032648)2.87181881
71negative regulation of interleukin-12 production (GO:0032695)2.86010819
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85635437
73purine nucleobase biosynthetic process (GO:0009113)2.85417315
74negative regulation of erythrocyte differentiation (GO:0045647)2.85401878
75positive regulation of cellular amide metabolic process (GO:0034250)2.84756003
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84556498
77negative T cell selection (GO:0043383)2.84491198
78mannose metabolic process (GO:0006013)2.84233368
79response to thyroid hormone (GO:0097066)2.82478588
80macrophage activation (GO:0042116)2.80048260
81regulation of B cell differentiation (GO:0045577)2.79222270
82detection of biotic stimulus (GO:0009595)2.79194378
83regulation of interleukin-12 production (GO:0032655)2.79169291
84negative regulation of interleukin-17 production (GO:0032700)2.78810072
85defense response to protozoan (GO:0042832)2.77640338
86positive thymic T cell selection (GO:0045059)2.76804717
87cellular response to ethanol (GO:0071361)2.75907197
88cellular extravasation (GO:0045123)2.75540243
89regulation of interleukin-2 biosynthetic process (GO:0045076)2.75346586
90amino sugar catabolic process (GO:0046348)2.73357558
91regulation of mast cell activation (GO:0033003)2.72742458
92activated T cell proliferation (GO:0050798)2.72117470
93negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.72046271
94positive regulation of mast cell activation (GO:0033005)2.71951262
95folic acid transport (GO:0015884)2.71867432
96positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.71010486
97response to protozoan (GO:0001562)2.69973550
98positive regulation of toll-like receptor signaling pathway (GO:0034123)2.69611390
99Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69517567
100regulation of mast cell degranulation (GO:0043304)2.66226421
101neutrophil mediated immunity (GO:0002446)2.66167303
102positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65449929
103regulation of antigen processing and presentation (GO:0002577)2.64882078
104ribosome assembly (GO:0042255)2.63361646
105leukocyte aggregation (GO:0070486)2.62436664
106regulation of interleukin-8 biosynthetic process (GO:0045414)2.61552547
107regulation of gamma-delta T cell activation (GO:0046643)2.61528696
108regulation of gamma-delta T cell differentiation (GO:0045586)2.58889056
109regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57038042
110mitotic metaphase plate congression (GO:0007080)2.56851298
111regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.55081191
112leukocyte mediated cytotoxicity (GO:0001909)2.54935669
113B cell receptor signaling pathway (GO:0050853)2.54919428
114regulation of RIG-I signaling pathway (GO:0039535)2.51739090
115lymphocyte mediated immunity (GO:0002449)2.51486331
116superoxide anion generation (GO:0042554)2.49988571
117negative regulation of mast cell activation (GO:0033004)2.49938761
118nucleobase biosynthetic process (GO:0046112)2.47380280
119T cell migration (GO:0072678)2.45486293
120regulation of mast cell activation involved in immune response (GO:0033006)2.45368749
121interferon-gamma-mediated signaling pathway (GO:0060333)2.43198228
122DNA replication checkpoint (GO:0000076)2.42214497
123interferon-gamma production (GO:0032609)2.41765756
124antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.38847094
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.38847094
126folic acid metabolic process (GO:0046655)2.38411984
127regulation of translation in response to stress (GO:0043555)2.38375249
128formation of translation preinitiation complex (GO:0001731)2.36454729
129positive regulation of isotype switching (GO:0045830)2.36445520
130antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.36128766
131glycosphingolipid catabolic process (GO:0046479)2.35738254
132antigen processing and presentation via MHC class Ib (GO:0002475)2.34852520
133antigen processing and presentation of endogenous antigen (GO:0019883)2.34349403
134cellular response to thyroid hormone stimulus (GO:0097067)2.32932515
135regulation of response to interferon-gamma (GO:0060330)2.32661016
136regulation of spindle organization (GO:0090224)2.30951695
137mast cell activation (GO:0045576)2.30238405
138mature B cell differentiation (GO:0002335)2.29999048
139cytokine secretion (GO:0050663)2.29379946
140myeloid leukocyte activation (GO:0002274)2.29276769
141transcription elongation from RNA polymerase I promoter (GO:0006362)2.28781011
142positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.27981572
143positive regulation of T cell apoptotic process (GO:0070234)2.27477331
144termination of RNA polymerase I transcription (GO:0006363)2.27447515
145regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.27027361
146myeloid dendritic cell activation (GO:0001773)2.26796314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.97499791
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.57668682
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.92263119
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.39119948
5* IRF8_27001747_Chip-Seq_BMDM_Mouse2.93717502
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83821550
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80772249
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.77892513
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72858926
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.56594930
11GATA1_22025678_ChIP-Seq_K562_Human2.53377924
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.52210172
13RUNX_20019798_ChIP-Seq_JUKART_Human2.50048315
14* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49657541
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47368273
16VDR_24787735_ChIP-Seq_THP-1_Human2.46150972
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36034861
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34635572
19* SPI1_23547873_ChIP-Seq_NB4_Human2.33512551
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13830773
21* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10373784
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01233859
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.00517432
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99915616
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99771093
26* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.99483239
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97602130
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94022994
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93808445
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.92572308
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.91199769
32VDR_23849224_ChIP-Seq_CD4+_Human1.90426248
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89916312
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87676966
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.87458709
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86578240
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80839201
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79192296
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79175325
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73527549
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73240267
42* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72905627
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72008730
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.70444723
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67531986
46* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66790217
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65352108
48* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56162660
49MYB_26560356_Chip-Seq_TH2_Human1.56076545
50SCL_19346495_ChIP-Seq_HPC-7_Human1.53797714
51* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53349125
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.52587874
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51158093
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50913882
55MYB_26560356_Chip-Seq_TH1_Human1.50709108
56* GATA1_19941827_ChIP-Seq_MEL_Mouse1.49623029
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49601357
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48287613
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.46730098
60TFEB_21752829_ChIP-Seq_HELA_Human1.45911424
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44496832
62GATA1_19941826_ChIP-Seq_K562_Human1.44488842
63MYC_22102868_ChIP-Seq_BL_Human1.43381174
64* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41138489
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40190231
66* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38341204
67FOXP3_21729870_ChIP-Seq_TREG_Human1.37514467
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36630149
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35821028
70VDR_21846776_ChIP-Seq_THP-1_Human1.35734860
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32280424
72* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29844809
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28379897
74MAF_26560356_Chip-Seq_TH1_Human1.27622396
75* PU_27001747_Chip-Seq_BMDM_Mouse1.26840384
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26519475
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26388857
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24388630
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23872729
80SPI1_23127762_ChIP-Seq_K562_Human1.22814611
81ELK1_19687146_ChIP-ChIP_HELA_Human1.22661481
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20623962
83VDR_24763502_ChIP-Seq_THP-1_Human1.20548188
84GABP_19822575_ChIP-Seq_HepG2_Human1.19766023
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.19258685
86DCP1A_22483619_ChIP-Seq_HELA_Human1.17596499
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15502655
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14574380
89GATA2_19941826_ChIP-Seq_K562_Human1.13528445
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13109982
91MAF_26560356_Chip-Seq_TH2_Human1.12136558
92KDM5A_27292631_Chip-Seq_BREAST_Human1.11753556
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11294829
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.11112046
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10910223
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09234263
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.08165382
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07799019
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07031010
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06711925
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06082897
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05441588
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05414690
104AR_21909140_ChIP-Seq_LNCAP_Human1.05186635
105TCF7_22412390_ChIP-Seq_EML_Mouse1.02131642
106UTX_26944678_Chip-Seq_JUKART_Human1.01746281
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01665480
108CIITA_25753668_ChIP-Seq_RAJI_Human1.01663974
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01081481
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00992004
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.00266181
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00052500
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99876164
114GATA3_26560356_Chip-Seq_TH2_Human0.99668889
115* GATA3_27048872_Chip-Seq_THYMUS_Human0.99539284
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98996093
117* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98920593
118E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98755357
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98189708
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98166135
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97493890
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95216272
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93452018
124STAT1_20625510_ChIP-Seq_HELA_Human0.92541579
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91954186
126SMRT_27268052_Chip-Seq_Bcells_Human0.85003344
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82230205
128KDM2B_26808549_Chip-Seq_DND41_Human0.81507147
129GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80168858
130BCL6_27268052_Chip-Seq_Bcells_Human0.76071589
131SPI1_20517297_ChIP-Seq_HL60_Human0.75809940
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74542918
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73359459
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73262033
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.69963139
136RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67741702
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.66334626
138BCOR_27268052_Chip-Seq_Bcells_Human0.64529570
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.64507045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.73665147
2MP0005058_abnormal_lysosome_morphology3.68710693
3MP0003693_abnormal_embryo_hatching2.91522322
4MP0008260_abnormal_autophagy2.86141275
5MP0003436_decreased_susceptibility_to2.85033560
6MP0006082_CNS_inflammation2.84921785
7MP0005671_abnormal_response_to2.78058887
8MP0002419_abnormal_innate_immunity2.65825667
9MP0005000_abnormal_immune_tolerance2.51047634
10* MP0002452_abnormal_antigen_presenting2.39957399
11MP0009785_altered_susceptibility_to2.39011200
12MP0002396_abnormal_hematopoietic_system2.36033217
13MP0009840_abnormal_foam_cell2.33719718
14MP0005025_abnormal_response_to2.32359338
15* MP0001800_abnormal_humoral_immune2.31862430
16MP0003303_peritoneal_inflammation2.28814812
17MP0002148_abnormal_hypersensitivity_rea2.27729256
18* MP0002723_abnormal_immune_serum2.26197878
19MP0000569_abnormal_digit_pigmentation2.20795297
20MP0009333_abnormal_splenocyte_physiolog2.15471505
21* MP0001819_abnormal_immune_cell2.12254289
22* MP0002420_abnormal_adaptive_immunity2.11327219
23MP0003172_abnormal_lysosome_physiology2.10490937
24MP0003111_abnormal_nucleus_morphology2.08834738
25MP0001790_abnormal_immune_system2.05810725
26MP0005387_immune_system_phenotype2.05810725
27MP0005464_abnormal_platelet_physiology2.04817873
28MP0000685_abnormal_immune_system1.96644043
29MP0003191_abnormal_cellular_cholesterol1.85486255
30MP0003724_increased_susceptibility_to1.84548812
31MP0009278_abnormal_bone_marrow1.84178546
32MP0002398_abnormal_bone_marrow1.82295652
33MP0005397_hematopoietic_system_phenotyp1.82262086
34MP0001545_abnormal_hematopoietic_system1.82262086
35MP0002405_respiratory_system_inflammati1.77742673
36* MP0000716_abnormal_immune_system1.74148528
37* MP0000689_abnormal_spleen_morphology1.70447277
38MP0010094_abnormal_chromosome_stability1.64078979
39MP0000465_gastrointestinal_hemorrhage1.62540273
40MP0002722_abnormal_immune_system1.62466070
41MP0005174_abnormal_tail_pigmentation1.61474460
42MP0010307_abnormal_tumor_latency1.60502014
43MP0002139_abnormal_hepatobiliary_system1.60296179
44MP0005310_abnormal_salivary_gland1.57500733
45MP0001853_heart_inflammation1.56131717
46MP0003077_abnormal_cell_cycle1.55977047
47MP0008058_abnormal_DNA_repair1.55544733
48MP0001845_abnormal_inflammatory_respons1.54229306
49MP0008057_abnormal_DNA_replication1.53944290
50MP0004957_abnormal_blastocyst_morpholog1.53561055
51MP0003448_altered_tumor_morphology1.51375759
52* MP0002429_abnormal_blood_cell1.50287744
53MP0003075_altered_response_to1.49280719
54MP0004808_abnormal_hematopoietic_stem1.48272671
55MP0001533_abnormal_skeleton_physiology1.46538078
56MP0005167_abnormal_blood-brain_barrier1.43614672
57MP0003763_abnormal_thymus_physiology1.43594730
58MP0000015_abnormal_ear_pigmentation1.42922566
59MP0004947_skin_inflammation1.42206346
60MP0000490_abnormal_crypts_of1.42019745
61MP0008469_abnormal_protein_level1.34687693
62MP0005451_abnormal_body_composition1.33568537
63MP0010155_abnormal_intestine_physiology1.32582210
64MP0004510_myositis1.26133846
65MP0003195_calcinosis1.23137551
66MP0002166_altered_tumor_susceptibility1.21292225
67MP0000858_altered_metastatic_potential1.20068333
68MP0002277_abnormal_respiratory_mucosa1.16383115
69MP0002006_tumorigenesis1.16048287
70MP0000703_abnormal_thymus_morphology1.14053094
71MP0004883_abnormal_blood_vessel1.13293354
72MP0008007_abnormal_cellular_replicative1.11340396
73MP0001873_stomach_inflammation1.09581180
74MP0003183_abnormal_peptide_metabolism1.09292928
75MP0003718_maternal_effect1.08012146
76MP0008004_abnormal_stomach_pH1.07958793
77MP0003806_abnormal_nucleotide_metabolis1.07349456
78MP0002132_abnormal_respiratory_system1.07004609
79MP0003329_amyloid_beta_deposits1.04549057
80MP0000371_diluted_coat_color1.04448762
81MP0003828_pulmonary_edema1.04380647
82MP0000343_altered_response_to1.00488149
83MP0005075_abnormal_melanosome_morpholog0.98335590
84MP0003786_premature_aging0.93679746
85MP0002019_abnormal_tumor_incidence0.89851011
86MP0005164_abnormal_response_to0.89758668
87MP0005257_abnormal_intraocular_pressure0.89697859
88MP0002998_abnormal_bone_remodeling0.87567833
89MP0001851_eye_inflammation0.85264414
90MP0000920_abnormal_myelination0.84799458
91MP0002095_abnormal_skin_pigmentation0.84525207
92MP0001542_abnormal_bone_strength0.83779187
93MP0003795_abnormal_bone_structure0.82055318
94MP0005365_abnormal_bile_salt0.81962969
95MP0000604_amyloidosis0.81515693
96MP0003866_abnormal_defecation0.81344291
97MP0000249_abnormal_blood_vessel0.79649943
98MP0002138_abnormal_hepatobiliary_system0.79279778
99MP0009764_decreased_sensitivity_to0.79252943
100MP0003656_abnormal_erythrocyte_physiolo0.78995373
101MP0005166_decreased_susceptibility_to0.78316611
102MP0000313_abnormal_cell_death0.78183544
103MP0001663_abnormal_digestive_system0.77755006
104MP0002877_abnormal_melanocyte_morpholog0.77677468
105MP0006054_spinal_hemorrhage0.77169538
106MP0003690_abnormal_glial_cell0.76635718
107MP0002933_joint_inflammation0.72964000
108MP0005647_abnormal_sex_gland0.71876920
109MP0004130_abnormal_muscle_cell0.69713927
110MP0002254_reproductive_system_inflammat0.68699950
111MP0003566_abnormal_cell_adhesion0.68367430
112MP0000350_abnormal_cell_proliferation0.67540877
113MP0009765_abnormal_xenobiotic_induced0.67365954
114MP0003300_gastrointestinal_ulcer0.66427098
115MP0005390_skeleton_phenotype0.65949907
116MP0009763_increased_sensitivity_to0.64596010
117MP0003453_abnormal_keratinocyte_physiol0.60761605
118MP0005165_increased_susceptibility_to0.58980831
119MP0002136_abnormal_kidney_physiology0.58922211
120MP0004782_abnormal_surfactant_physiolog0.58429199
121MP0005621_abnormal_cell_physiology0.58381029
122MP0009115_abnormal_fat_cell0.57209323
123MP0008932_abnormal_embryonic_tissue0.57050152
124MP0001730_embryonic_growth_arrest0.56992955
125MP0008874_decreased_physiological_sensi0.55823769
126MP0000609_abnormal_liver_physiology0.54119541
127MP0003091_abnormal_cell_migration0.50834070

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.18515385
2Recurrent bacterial skin infections (HP:0005406)5.38389274
3Eczematoid dermatitis (HP:0000976)5.03623211
4Vacuolated lymphocytes (HP:0001922)4.66234748
5Increased cerebral lipofuscin (HP:0011813)4.42980244
6Abnormality of macrophages (HP:0004311)4.40287218
7Recurrent gram-negative bacterial infections (HP:0005420)4.28292300
8Abnormality of liposaccharide metabolism (HP:0010968)4.11359612
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.11359612
10Abnormality of glycolipid metabolism (HP:0010969)4.11359612
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.92897112
12Pustule (HP:0200039)3.67031101
13Chronic obstructive pulmonary disease (HP:0006510)3.66774732
14Obstructive lung disease (HP:0006536)3.66774732
15Recurrent fungal infections (HP:0002841)3.62281239
16Systemic lupus erythematosus (HP:0002725)3.40949610
17Recurrent skin infections (HP:0001581)3.32571246
18Prostate neoplasm (HP:0100787)3.31047986
19Agnosia (HP:0010524)3.26375363
20Purpura (HP:0000979)3.18459638
21Disinhibition (HP:0000734)3.18065097
22Myositis (HP:0100614)3.14845036
23Mediastinal lymphadenopathy (HP:0100721)3.11793125
24Gingivitis (HP:0000230)3.04848351
25Dysostosis multiplex (HP:0000943)3.04153409
26Autoimmune thrombocytopenia (HP:0001973)3.03736387
27Recurrent viral infections (HP:0004429)2.97285774
28Mutism (HP:0002300)2.95810398
29Pulmonary infiltrates (HP:0002113)2.86111070
30Elevated erythrocyte sedimentation rate (HP:0003565)2.81725713
31Stomatitis (HP:0010280)2.77743018
32Birth length less than 3rd percentile (HP:0003561)2.77487265
33Petechiae (HP:0000967)2.69967304
34Basal ganglia calcification (HP:0002135)2.64553531
35Chronic mucocutaneous candidiasis (HP:0002728)2.64512374
36Recurrent cutaneous fungal infections (HP:0011370)2.64512374
37Entropion (HP:0000621)2.61567528
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.60111760
39Optic neuritis (HP:0100653)2.58985749
40Retrobulbar optic neuritis (HP:0100654)2.58985749
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57757292
42Orchitis (HP:0100796)2.57411831
43IgM deficiency (HP:0002850)2.56437294
44Cheilitis (HP:0100825)2.53398498
45Hematochezia (HP:0002573)2.51226627
46Periodontitis (HP:0000704)2.50597873
47Hepatosplenomegaly (HP:0001433)2.50229300
48Hemoptysis (HP:0002105)2.48385677
49Abnormality of the prostate (HP:0008775)2.47718106
50Osteolytic defects of the hand bones (HP:0009699)2.46131836
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.46131836
52Personality changes (HP:0000751)2.45335035
53Gingival bleeding (HP:0000225)2.41976425
54Glomerulonephritis (HP:0000099)2.41965816
55Axonal loss (HP:0003447)2.41714314
56Upper motor neuron abnormality (HP:0002127)2.37630589
57Leukocytosis (HP:0001974)2.36693143
58Increased IgM level (HP:0003496)2.36390954
59T lymphocytopenia (HP:0005403)2.36389161
60Abnormality of T cell number (HP:0011839)2.30784730
61Increased serum ferritin (HP:0003281)2.30538703
62Impulsivity (HP:0100710)2.29255043
63Cellulitis (HP:0100658)2.28831166
64Neurofibrillary tangles (HP:0002185)2.27294133
65Abnormality of eosinophils (HP:0001879)2.26835492
66Meningitis (HP:0001287)2.26738225
67IgG deficiency (HP:0004315)2.25224977
68Prolonged bleeding time (HP:0003010)2.23755733
69Autoimmune hemolytic anemia (HP:0001890)2.21757157
70Eosinophilia (HP:0001880)2.20488244
71Vasculitis (HP:0002633)2.19621910
72Urticaria (HP:0001025)2.19432955
73Keratoconjunctivitis sicca (HP:0001097)2.18794863
74Conjunctival telangiectasia (HP:0000524)2.18768728
75Metaphyseal irregularity (HP:0003025)2.17634270
76Ureteral duplication (HP:0000073)2.17571842
77Rough bone trabeculation (HP:0100670)2.17305807
78Chronic otitis media (HP:0000389)2.14627222
79Global brain atrophy (HP:0002283)2.13915990
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.13604333
81Abnormality of iron homeostasis (HP:0011031)2.13414892
82Prolonged neonatal jaundice (HP:0006579)2.12941421
83Urinary glycosaminoglycan excretion (HP:0003541)2.12566779
84Mucopolysacchariduria (HP:0008155)2.12566779
85Abnormality of T cells (HP:0002843)2.11010246
86Recurrent pneumonia (HP:0006532)2.08445972
87Encephalitis (HP:0002383)2.07868136
88Abnormality of polysaccharide metabolism (HP:0011012)2.05415013
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05415013
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05415013
91Polyneuropathy (HP:0001271)2.05008100
92Keratoconjunctivitis (HP:0001096)2.04973582
93Inappropriate behavior (HP:0000719)2.04739101
94Abnormality of the periventricular white matter (HP:0002518)2.04192712
95Diminished motivation (HP:0000745)2.04026205
96Gastrointestinal infarctions (HP:0005244)2.03149184
97Apathy (HP:0000741)2.01935115
98Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01537375
99Bone marrow hypocellularity (HP:0005528)2.00531155
100Neurodegeneration (HP:0002180)2.00066665
101Inflammation of the large intestine (HP:0002037)1.99546423
102Leukopenia (HP:0001882)1.99011749
103Albinism (HP:0001022)1.98705231
104Arterial thrombosis (HP:0004420)1.98694825
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98596590
106Spontaneous hematomas (HP:0007420)1.98578086
107Chest pain (HP:0100749)1.98474021
108Joint swelling (HP:0001386)1.98450805
109Panhypogammaglobulinemia (HP:0003139)1.98313626
110Colitis (HP:0002583)1.97702416
111Anorexia (HP:0002039)1.96927540
112Myocardial infarction (HP:0001658)1.95325461
113Osteomyelitis (HP:0002754)1.94234466
114Amaurosis fugax (HP:0100576)1.93734594
115Epistaxis (HP:0000421)1.93357249
116Pulmonary embolism (HP:0002204)1.93078164
117Neuronal loss in central nervous system (HP:0002529)1.93073829
118Combined immunodeficiency (HP:0005387)1.92582903
119Granulocytopenia (HP:0001913)1.92288859
120Abnormality of the umbilical cord (HP:0010881)1.91611443
121Loss of speech (HP:0002371)1.90598143
122Chromsome breakage (HP:0040012)1.89679327
123Thyroiditis (HP:0100646)1.87912631
124Thoracic kyphosis (HP:0002942)1.87551947
125Progressive neurologic deterioration (HP:0002344)1.86602015
126Thrombocytosis (HP:0001894)1.86136302
127Lymphoma (HP:0002665)1.86129913
128Abnormality of transition element cation homeostasis (HP:0011030)1.85967439
129Poor head control (HP:0002421)1.85450693
130Degeneration of anterior horn cells (HP:0002398)1.84941929
131Abnormality of the anterior horn cell (HP:0006802)1.84941929
132Interstitial pulmonary disease (HP:0006530)1.84856128
133Spinal muscular atrophy (HP:0007269)1.84640203
134Abnormality of T cell physiology (HP:0011840)1.84467817
135Gastrointestinal inflammation (HP:0004386)1.83628559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.24065300
2BLK3.22539200
3MAP4K13.13420290
4BUB12.92971341
5TXK2.86775552
6WEE12.85496316
7IRAK42.55423534
8RIPK42.54800212
9KIT2.52185533
10TYK22.23082754
11ZAP702.21119660
12IRAK32.20774681
13NEK22.13217216
14TGFBR22.00597654
15EIF2AK11.87354888
16TBK11.81103047
17TSSK61.73314703
18FGR1.71869403
19BMPR21.71403365
20IKBKB1.68667968
21TEC1.68443873
22CSF1R1.67247432
23MAP3K141.64183106
24PRPF4B1.58617574
25MAP3K111.48358879
26RPS6KA41.45744164
27STK101.43175264
28ADRBK21.41303557
29STK161.39175360
30IKBKE1.38796155
31PIM21.36575703
32SYK1.35845288
33EIF2AK31.34393134
34PLK41.33269084
35PIM11.32508685
36BRSK21.31944233
37MAP2K31.27326449
38JAK31.27255796
39EIF2AK21.26038211
40MKNK21.25694634
41ACVR1B1.24136964
42JAK11.23739013
43BTK1.21004321
44NEK91.16653866
45HCK1.15506657
46LYN1.14908761
47ITK1.12471518
48TNK21.09292491
49TAOK31.08971286
50LCK1.04960790
51DYRK31.04742459
52CSK1.00364021
53NUAK10.99792185
54CDK40.99367225
55CDC42BPA0.97407305
56STK40.97032954
57STK30.95796457
58MARK30.95447355
59SRPK10.94995743
60PLK10.94854236
61PIK3CG0.93769663
62TAOK10.91903055
63CCNB10.89309571
64IRAK10.88006163
65MKNK10.86604274
66GRK70.85777876
67MAP3K10.82946483
68NLK0.81520798
69STK240.76764949
70CAMKK20.76258788
71CLK10.75033817
72PRKCQ0.74625507
73ALK0.73999808
74PDK20.73913708
75CDK60.73160105
76MAP3K30.72387763
77CHUK0.71063896
78FES0.70562129
79TESK20.69063542
80ZAK0.67698640
81AURKB0.67564932
82AKT30.66289103
83CAMKK10.65232177
84TTK0.64869970
85MAPK120.64848762
86DDR20.64839402
87MAP3K130.63911297
88JAK20.62514729
89ATR0.60339038
90MAP3K80.58465690
91MOS0.57766294
92CAMK1D0.57671939
93SIK30.57449187
94MAP2K60.56940411
95PBK0.56687607
96DAPK20.56454099
97MATK0.56147106
98CDK70.55606415
99PDPK10.55120044
100CAMK1G0.53695238
101MAPK70.52985367
102IRAK20.50695052
103TRPM70.49731374
104PAK40.49585679
105PLK30.49269751
106FGFR40.48731403
107HIPK20.47432473
108CHEK20.45986823
109RPS6KA60.45677879
110RPS6KL10.45622350
111RPS6KC10.45622350
112GRK60.45609932
113ABL10.45283635
114FYN0.45205468
115PRKCD0.44971555
116EPHA30.44438151
117ABL20.44256187
118YES10.42857316
119MELK0.42695093
120BRSK10.42057370
121EGFR0.41075378
122TAOK20.40055236
123MAP3K50.39472949
124MAPK40.39347633
125VRK10.39235295
126PDK10.39231637
127IGF1R0.35907605
128RPS6KA20.35658109
129RPS6KA50.35616935
130FGFR30.34707616
131CSNK2A10.34563279
132GRK10.34305127
133MAPKAPK20.33558988
134PNCK0.31692172
135ERN10.31504464
136SCYL20.31441501
137TGFBR10.28896346
138SGK30.28681878
139MARK20.28439632
140EPHB10.27772918
141INSR0.27488341
142SGK20.27371543
143CAMK40.25662438
144BMX0.24589556
145MAPK110.23765847

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.15691446
2Staphylococcus aureus infection_Homo sapiens_hsa051502.47623529
3Lysosome_Homo sapiens_hsa041422.44966472
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30171202
5RNA polymerase_Homo sapiens_hsa030202.28775839
6Proteasome_Homo sapiens_hsa030502.21305885
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.19900506
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19277448
9Leishmaniasis_Homo sapiens_hsa051402.17784202
10Type I diabetes mellitus_Homo sapiens_hsa049402.07603997
11Antigen processing and presentation_Homo sapiens_hsa046122.00902813
12Other glycan degradation_Homo sapiens_hsa005111.98604829
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.97080805
14Regulation of autophagy_Homo sapiens_hsa041401.97031450
15Osteoclast differentiation_Homo sapiens_hsa043801.81474517
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.78331676
17Primary immunodeficiency_Homo sapiens_hsa053401.75061162
18Measles_Homo sapiens_hsa051621.71095636
19DNA replication_Homo sapiens_hsa030301.66720517
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65380565
21Legionellosis_Homo sapiens_hsa051341.64385897
22RNA transport_Homo sapiens_hsa030131.58196465
23Hematopoietic cell lineage_Homo sapiens_hsa046401.57630090
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57169347
25Graft-versus-host disease_Homo sapiens_hsa053321.55509846
26Tuberculosis_Homo sapiens_hsa051521.55169038
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54317203
28B cell receptor signaling pathway_Homo sapiens_hsa046621.51204403
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51083730
30Rheumatoid arthritis_Homo sapiens_hsa053231.45186593
31Base excision repair_Homo sapiens_hsa034101.43199137
32Allograft rejection_Homo sapiens_hsa053301.42448972
33Homologous recombination_Homo sapiens_hsa034401.42355368
34Herpes simplex infection_Homo sapiens_hsa051681.38114280
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34648529
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34175303
37Pyrimidine metabolism_Homo sapiens_hsa002401.31944061
38Mismatch repair_Homo sapiens_hsa034301.28266477
39Pertussis_Homo sapiens_hsa051331.27570215
40Phagosome_Homo sapiens_hsa041451.25770659
41Epstein-Barr virus infection_Homo sapiens_hsa051691.25200022
42Asthma_Homo sapiens_hsa053101.19845414
43Influenza A_Homo sapiens_hsa051641.19540319
44Malaria_Homo sapiens_hsa051441.19071105
45Spliceosome_Homo sapiens_hsa030401.18596841
46Cell cycle_Homo sapiens_hsa041101.17826199
47Apoptosis_Homo sapiens_hsa042101.15711466
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07865059
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.06991805
50Ribosome_Homo sapiens_hsa030101.05891030
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02395139
52Nucleotide excision repair_Homo sapiens_hsa034201.02201210
53p53 signaling pathway_Homo sapiens_hsa041151.02059592
54Fanconi anemia pathway_Homo sapiens_hsa034600.98688355
55Basal transcription factors_Homo sapiens_hsa030220.97773307
56Pentose phosphate pathway_Homo sapiens_hsa000300.96798103
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95012412
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94933839
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92141547
60T cell receptor signaling pathway_Homo sapiens_hsa046600.91370710
61African trypanosomiasis_Homo sapiens_hsa051430.91271146
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90340804
63Toxoplasmosis_Homo sapiens_hsa051450.86565073
64Non-homologous end-joining_Homo sapiens_hsa034500.85983925
65Sphingolipid metabolism_Homo sapiens_hsa006000.85825753
66Shigellosis_Homo sapiens_hsa051310.82136463
67Hepatitis B_Homo sapiens_hsa051610.81667787
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81341340
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77175692
70TNF signaling pathway_Homo sapiens_hsa046680.77006313
71Caffeine metabolism_Homo sapiens_hsa002320.76362464
72Chemokine signaling pathway_Homo sapiens_hsa040620.75746022
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75130560
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.74644754
75Folate biosynthesis_Homo sapiens_hsa007900.72782760
76Salmonella infection_Homo sapiens_hsa051320.72476791
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70228960
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.66491447
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.66030050
80Autoimmune thyroid disease_Homo sapiens_hsa053200.65244225
81Purine metabolism_Homo sapiens_hsa002300.64733499
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.62660127
83Acute myeloid leukemia_Homo sapiens_hsa052210.60772149
84Fructose and mannose metabolism_Homo sapiens_hsa000510.59910637
85Hepatitis C_Homo sapiens_hsa051600.55001391
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.54985126
87Collecting duct acid secretion_Homo sapiens_hsa049660.53762526
88Vitamin digestion and absorption_Homo sapiens_hsa049770.52544254
89Viral carcinogenesis_Homo sapiens_hsa052030.51649096
90Prolactin signaling pathway_Homo sapiens_hsa049170.51385697
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46982733
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46636814
93Renin-angiotensin system_Homo sapiens_hsa046140.46462789
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45770611
95Platelet activation_Homo sapiens_hsa046110.44580153
96HTLV-I infection_Homo sapiens_hsa051660.44061485
97Chronic myeloid leukemia_Homo sapiens_hsa052200.43556657
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42186479
99Endocytosis_Homo sapiens_hsa041440.42138151
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41560543
101VEGF signaling pathway_Homo sapiens_hsa043700.40780299
102RNA degradation_Homo sapiens_hsa030180.40756971
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.40508154
104Viral myocarditis_Homo sapiens_hsa054160.39778068
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39227252
106Amoebiasis_Homo sapiens_hsa051460.38730488
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.38403464
108Ether lipid metabolism_Homo sapiens_hsa005650.38086932
109Systemic lupus erythematosus_Homo sapiens_hsa053220.37398681
110mTOR signaling pathway_Homo sapiens_hsa041500.36501239
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36410596
112Non-small cell lung cancer_Homo sapiens_hsa052230.36186196
113Pancreatic cancer_Homo sapiens_hsa052120.35964190
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35278904
115One carbon pool by folate_Homo sapiens_hsa006700.35251457
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35237856
117mRNA surveillance pathway_Homo sapiens_hsa030150.34839860
118FoxO signaling pathway_Homo sapiens_hsa040680.34192131
119Complement and coagulation cascades_Homo sapiens_hsa046100.34018904
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30578518
121PPAR signaling pathway_Homo sapiens_hsa033200.30494612
122Dorso-ventral axis formation_Homo sapiens_hsa043200.29963064
123HIF-1 signaling pathway_Homo sapiens_hsa040660.29372872
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.28080747
125Type II diabetes mellitus_Homo sapiens_hsa049300.26292888
126Mineral absorption_Homo sapiens_hsa049780.24877137
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23525530
128Vibrio cholerae infection_Homo sapiens_hsa051100.23050359
129Prion diseases_Homo sapiens_hsa050200.22670583
130GnRH signaling pathway_Homo sapiens_hsa049120.20126743
131Renal cell carcinoma_Homo sapiens_hsa052110.19795141
132Insulin resistance_Homo sapiens_hsa049310.19768143
133Arachidonic acid metabolism_Homo sapiens_hsa005900.19080169
134Galactose metabolism_Homo sapiens_hsa000520.17029578
135MAPK signaling pathway_Homo sapiens_hsa040100.15988491

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