CD82

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.02890355
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.02890355
3antigen processing and presentation of endogenous antigen (GO:0019883)5.88667870
4positive regulation of gamma-delta T cell activation (GO:0046645)4.78747878
5negative thymic T cell selection (GO:0045060)4.50568729
6negative T cell selection (GO:0043383)4.44291934
7regulation of gamma-delta T cell differentiation (GO:0045586)4.42185163
8immunoglobulin mediated immune response (GO:0016064)4.33907004
9regulation of gamma-delta T cell activation (GO:0046643)4.00196137
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.93704042
11regulation of interleukin-12 biosynthetic process (GO:0045075)3.92854411
12positive thymic T cell selection (GO:0045059)3.87643608
13response to interleukin-15 (GO:0070672)3.69407468
14thymic T cell selection (GO:0045061)3.61604016
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52049051
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.51653834
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.51653834
18modulation by symbiont of host immune response (GO:0052553)3.51653834
19positive regulation by symbiont of host defense response (GO:0052509)3.51653834
20modulation by symbiont of host defense response (GO:0052031)3.51653834
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.51653834
22response to protozoan (GO:0001562)3.49039396
23NIK/NF-kappaB signaling (GO:0038061)3.48492085
24leukocyte aggregation (GO:0070486)3.47628442
25T-helper 1 type immune response (GO:0042088)3.42667226
26B cell mediated immunity (GO:0019724)3.41975186
27negative regulation of interleukin-12 production (GO:0032695)3.38550164
28defense response to protozoan (GO:0042832)3.36878134
29CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.35423557
30interferon-gamma-mediated signaling pathway (GO:0060333)3.34279237
31cellular response to interleukin-15 (GO:0071350)3.32405583
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32260754
33regulation of T cell tolerance induction (GO:0002664)3.32226276
34tolerance induction (GO:0002507)3.30491314
35pyrimidine ribonucleoside catabolic process (GO:0046133)3.28252469
36regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27928228
37JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.27314750
38regulation of antigen processing and presentation (GO:0002577)3.26112405
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.23042968
40response to peptidoglycan (GO:0032494)3.22575173
41positive regulation of B cell differentiation (GO:0045579)3.21237914
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18021221
43ATP synthesis coupled proton transport (GO:0015986)3.18021221
44detection of bacterium (GO:0016045)3.17956043
45negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.16768717
46response to interferon-beta (GO:0035456)3.16010019
47T cell selection (GO:0045058)3.13516619
48regulation of isotype switching to IgG isotypes (GO:0048302)3.13365292
49regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11531960
50cellular response to interferon-beta (GO:0035458)3.04954636
51interferon-gamma production (GO:0032609)3.04658130
52viral transcription (GO:0019083)3.03609296
53negative regulation of B cell apoptotic process (GO:0002903)3.02087299
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01628615
55T cell costimulation (GO:0031295)2.99892206
56detection of other organism (GO:0098543)2.99767641
57regulation of alpha-beta T cell proliferation (GO:0046640)2.96255840
58regulation of cholesterol homeostasis (GO:2000188)2.94571102
59lymphocyte costimulation (GO:0031294)2.94127608
60positive T cell selection (GO:0043368)2.93477170
61germinal center formation (GO:0002467)2.90841447
62growth hormone receptor signaling pathway (GO:0060396)2.89949908
63regulation of vitamin D biosynthetic process (GO:0060556)2.88953121
64B cell receptor signaling pathway (GO:0050853)2.88892435
65antigen processing and presentation via MHC class Ib (GO:0002475)2.87831014
66positive regulation of humoral immune response (GO:0002922)2.87134653
67regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.86495961
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.86446721
69L-phenylalanine catabolic process (GO:0006559)2.86446721
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.82485994
71negative regulation of myeloid cell apoptotic process (GO:0033033)2.82139159
72sequestering of actin monomers (GO:0042989)2.82077316
73regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81306903
74regulation of natural killer cell mediated immunity (GO:0002715)2.81306903
75positive regulation of interleukin-2 production (GO:0032743)2.80919603
76positive regulation of natural killer cell mediated immunity (GO:0002717)2.80202230
77positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.80202230
78regulation of interleukin-2 biosynthetic process (GO:0045076)2.80099882
79positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.79624316
80regulation of B cell apoptotic process (GO:0002902)2.79176643
81cytidine deamination (GO:0009972)2.75461196
82cytidine metabolic process (GO:0046087)2.75461196
83cytidine catabolic process (GO:0006216)2.75461196
84translational termination (GO:0006415)2.74924166
85positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73556157
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.72785184
87L-phenylalanine metabolic process (GO:0006558)2.72785184
88macrophage activation involved in immune response (GO:0002281)2.72520519
89DNA deamination (GO:0045006)2.72501523
90negative regulation of cell killing (GO:0031342)2.72124338
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72124338
92membrane protein intracellular domain proteolysis (GO:0031293)2.71822652
93mature B cell differentiation involved in immune response (GO:0002313)2.70759039
94positive regulation of lymphocyte migration (GO:2000403)2.70544602
95T cell migration (GO:0072678)2.70314517
96purinergic nucleotide receptor signaling pathway (GO:0035590)2.68839868
97valine metabolic process (GO:0006573)2.68385100
98pyrimidine nucleotide catabolic process (GO:0006244)2.68350688
99tumor necrosis factor-mediated signaling pathway (GO:0033209)2.68259699
100regulation of interferon-beta biosynthetic process (GO:0045357)2.68100680
101regulation of leukocyte mediated cytotoxicity (GO:0001910)2.65977540
102cellular response to interferon-gamma (GO:0071346)2.65570522
103T cell receptor signaling pathway (GO:0050852)2.65381056
104respiratory burst (GO:0045730)2.64516311
105neutrophil activation involved in immune response (GO:0002283)2.64348941
106positive regulation of tolerance induction (GO:0002645)2.64308104
107regulation of B cell differentiation (GO:0045577)2.62918117
108positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.62907121
109positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.62876274
110regulation of T cell mediated cytotoxicity (GO:0001914)2.62762281
111myeloid dendritic cell differentiation (GO:0043011)2.62678000
112positive regulation of defense response to virus by host (GO:0002230)2.62590861
113regulation of lymphocyte migration (GO:2000401)2.60433595
114response to host immune response (GO:0052572)2.59782506
115response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59782506
116regulation of B cell receptor signaling pathway (GO:0050855)2.59380074
117regulation of tolerance induction (GO:0002643)2.58964128
118regulation of response to interferon-gamma (GO:0060330)2.58745566
119positive regulation of prostaglandin secretion (GO:0032308)2.58640206
120amyloid precursor protein catabolic process (GO:0042987)2.58472472
121hydrogen peroxide biosynthetic process (GO:0050665)2.58245314
122positive regulation of natural killer cell differentiation (GO:0032825)2.57662811
123positive regulation of T cell mediated cytotoxicity (GO:0001916)2.55005246
124positive regulation of B cell activation (GO:0050871)2.54022836
125positive regulation of interleukin-10 production (GO:0032733)2.53779106
126negative regulation of innate immune response (GO:0045824)2.53645381
127positive regulation of B cell proliferation (GO:0030890)2.52815575
128positive regulation of interferon-gamma production (GO:0032729)2.52606782
129positive regulation of DNA recombination (GO:0045911)2.51973721
130hepatocyte apoptotic process (GO:0097284)2.51756533
131response to type I interferon (GO:0034340)2.51371819
132leukocyte cell-cell adhesion (GO:0007159)2.51360278
133positive regulation of cell killing (GO:0031343)2.50089138
134regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.49621468
135positive regulation of antigen processing and presentation (GO:0002579)2.48866865
136cellular response to growth hormone stimulus (GO:0071378)2.47109047
137regulation of immunoglobulin secretion (GO:0051023)2.46562126
138myeloid dendritic cell activation (GO:0001773)2.45734809
139cellular response to type I interferon (GO:0071357)2.45349107
140type I interferon signaling pathway (GO:0060337)2.45349107
141response to muramyl dipeptide (GO:0032495)2.43787485
142negative regulation of cholesterol transport (GO:0032375)2.43176277
143negative regulation of sterol transport (GO:0032372)2.43176277
144negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42602248
145regulation of T cell receptor signaling pathway (GO:0050856)2.41255596
146regulation of cell killing (GO:0031341)2.40823147
147myelin maintenance (GO:0043217)2.39573424
148positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.38417899
149protein-lipid complex assembly (GO:0065005)2.38174479
150Peyers patch development (GO:0048541)2.37971446
151mucosal-associated lymphoid tissue development (GO:0048537)2.37971446
152regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.36943206
153positive regulation of lipoprotein lipase activity (GO:0051006)2.35527926
154positive regulation of triglyceride lipase activity (GO:0061365)2.35527926
155regulation of natural killer cell differentiation (GO:0032823)2.35253228
156regulation of memory T cell differentiation (GO:0043380)2.35101819
157positive regulation of isotype switching (GO:0045830)2.34302446
158negative regulation of erythrocyte differentiation (GO:0045647)2.34203772
159positive regulation of B cell mediated immunity (GO:0002714)2.32035162
160positive regulation of immunoglobulin mediated immune response (GO:0002891)2.32035162
161aromatic amino acid family catabolic process (GO:0009074)2.31809972
162CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.31013844
163T-helper cell differentiation (GO:0042093)2.31013844
164creatine metabolic process (GO:0006600)2.30345257
165antigen receptor-mediated signaling pathway (GO:0050851)2.30231186
166regulation of extracellular matrix disassembly (GO:0010715)2.30102461
167positive regulation of immunoglobulin production (GO:0002639)2.28380460
168fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.28336012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.82857569
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.94885894
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.88752674
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.85556822
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04358744
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.89733139
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.86505520
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82437637
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68858601
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58417407
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.51268459
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44441626
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.44106374
14* RUNX_20019798_ChIP-Seq_JUKART_Human2.43184146
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42526141
16* LXR_22158963_ChIP-Seq_LIVER_Mouse2.39065559
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33176670
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30764119
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26141595
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.24351882
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18181143
22MAF_26560356_Chip-Seq_TH1_Human2.13137185
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11643833
24* MYB_26560356_Chip-Seq_TH2_Human2.10480518
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.09791830
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08928525
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08233638
28* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06080074
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04340745
30* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92144635
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91958861
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91540198
33MYC_22102868_ChIP-Seq_BL_Human1.90243418
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.86683234
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80776036
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79165620
37* BCL6_27268052_Chip-Seq_Bcells_Human1.78715726
38* MYB_26560356_Chip-Seq_TH1_Human1.77418315
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76733987
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75852226
41VDR_21846776_ChIP-Seq_THP-1_Human1.75193224
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74525896
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73274508
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72808512
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72482001
46* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71962577
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69210414
48SCL_19346495_ChIP-Seq_HPC-7_Human1.66687264
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66125885
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65913443
51* UTX_26944678_Chip-Seq_JUKART_Human1.65115856
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63597889
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62939684
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.59490021
55* CLOCK_20551151_ChIP-Seq_293T_Human1.59431793
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.56692275
57GATA1_22025678_ChIP-Seq_K562_Human1.53099115
58* VDR_24763502_ChIP-Seq_THP-1_Human1.51460433
59* BCOR_27268052_Chip-Seq_Bcells_Human1.49526326
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48311469
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.47824961
62* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.45403201
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.45038025
64* GATA3_27048872_Chip-Seq_THYMUS_Human1.44357577
65* TCF7_22412390_ChIP-Seq_EML_Mouse1.44241500
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42615754
67* ESR2_21235772_ChIP-Seq_MCF-7_Human1.41820542
68* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41797298
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.41617851
70MAF_26560356_Chip-Seq_TH2_Human1.41244822
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40739863
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.40735387
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.40043444
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.38460403
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.37897531
76GATA1_19941826_ChIP-Seq_K562_Human1.37777382
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36485585
78* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34216939
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30838677
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30556155
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29766496
82* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28740718
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27449295
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26016361
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25840910
86* GATA1_19941827_ChIP-Seq_MEL_Mouse1.25389736
87* LXR_22292898_ChIP-Seq_THP-1_Human1.23316760
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22475560
89* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21800924
90* P300_27268052_Chip-Seq_Bcells_Human1.21762071
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20799038
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19865783
93* GATA2_19941826_ChIP-Seq_K562_Human1.19338962
94VDR_23849224_ChIP-Seq_CD4+_Human1.18895595
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.17314500
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.16284253
97* KDM2B_26808549_Chip-Seq_DND41_Human1.15913797
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15659010
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.14444854
100SPI1_23127762_ChIP-Seq_K562_Human1.14119811
101ETS1_20019798_ChIP-Seq_JURKAT_Human1.13411017
102* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13249345
103SPI1_20517297_ChIP-Seq_HL60_Human1.12410580
104* RACK7_27058665_Chip-Seq_MCF-7_Human1.11944510
105* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11743439
106SPI1_23547873_ChIP-Seq_NB4_Human1.11606907
107* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10979342
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10885833
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.10726399
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10650287
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10595152
112STAT1_20625510_ChIP-Seq_HELA_Human1.10250596
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09708831
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09586521
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09509223
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09370816
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07503906
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06698098
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05869613
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05785576
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05736936
122* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05597593
123PU_27001747_Chip-Seq_BMDM_Mouse1.05431949
124STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05378159
125* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04657394
126GATA4_25053715_ChIP-Seq_YYC3_Human1.04626141
127ESR1_21235772_ChIP-Seq_MCF-7_Human1.03858176
128P68_20966046_ChIP-Seq_HELA_Human1.03652039
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03132807
130EGR1_19032775_ChIP-ChIP_M12_Human1.02905675
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02897338
132CIITA_25753668_ChIP-Seq_RAJI_Human1.02887338
133SA1_27219007_Chip-Seq_ERYTHROID_Human1.02493449
134CTCF_20526341_ChIP-Seq_ESCs_Human1.02004439
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98837512
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98453325
137GATA6_25053715_ChIP-Seq_YYC3_Human0.97671632
138* SOX2_20726797_ChIP-Seq_SW620_Human0.97513469
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95804607
140* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95428221
141* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93486860
142* VDR_24787735_ChIP-Seq_THP-1_Human0.92638429
143SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92459918
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92360400
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92316578
146CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91075076
147GATA3_26560356_Chip-Seq_TH2_Human0.91047258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.57131132
2MP0005671_abnormal_response_to2.91706328
3MP0001835_abnormal_antigen_presentation2.88849406
4MP0005360_urolithiasis2.87061489
5MP0002139_abnormal_hepatobiliary_system2.78419944
6MP0003763_abnormal_thymus_physiology2.72745687
7MP0005387_immune_system_phenotype2.58569219
8MP0001790_abnormal_immune_system2.58569219
9MP0003300_gastrointestinal_ulcer2.55700037
10MP0006082_CNS_inflammation2.49936159
11MP0009785_altered_susceptibility_to2.47353816
12MP0001873_stomach_inflammation2.46547902
13MP0003436_decreased_susceptibility_to2.33730087
14MP0002138_abnormal_hepatobiliary_system2.27755310
15MP0001800_abnormal_humoral_immune2.25920761
16MP0005000_abnormal_immune_tolerance2.24339975
17MP0009840_abnormal_foam_cell2.22071914
18MP0003724_increased_susceptibility_to2.11678576
19MP0004947_skin_inflammation2.06652079
20MP0002254_reproductive_system_inflammat2.06061696
21MP0010155_abnormal_intestine_physiology2.02639375
22MP0002723_abnormal_immune_serum2.00531865
23MP0005025_abnormal_response_to1.99923605
24MP0005365_abnormal_bile_salt1.99861468
25MP0002166_altered_tumor_susceptibility1.93165189
26MP0002405_respiratory_system_inflammati1.90187680
27MP0009278_abnormal_bone_marrow1.89675954
28MP0002452_abnormal_antigen_presenting1.85496939
29MP0003191_abnormal_cellular_cholesterol1.84326686
30MP0002420_abnormal_adaptive_immunity1.83854011
31MP0001819_abnormal_immune_cell1.82786768
32MP0005085_abnormal_gallbladder_physiolo1.82099329
33MP0008875_abnormal_xenobiotic_pharmacok1.77328481
34MP0003866_abnormal_defecation1.76778815
35MP0002148_abnormal_hypersensitivity_rea1.75261408
36MP0003303_peritoneal_inflammation1.70019238
37MP0009333_abnormal_splenocyte_physiolog1.69981755
38MP0000343_altered_response_to1.69929054
39MP0002419_abnormal_innate_immunity1.69044800
40MP0001845_abnormal_inflammatory_respons1.66165619
41MP0002277_abnormal_respiratory_mucosa1.65585336
42MP0002933_joint_inflammation1.64445220
43MP0004510_myositis1.59366050
44MP0001666_abnormal_nutrient_absorption1.57837431
45MP0003252_abnormal_bile_duct1.56540514
46MP0002398_abnormal_bone_marrow1.53045158
47MP0010234_abnormal_vibrissa_follicle1.51975229
48MP0000716_abnormal_immune_system1.51468994
49MP0003806_abnormal_nucleotide_metabolis1.51214729
50MP0003656_abnormal_erythrocyte_physiolo1.48452883
51MP0005464_abnormal_platelet_physiology1.47934978
52MP0009379_abnormal_foot_pigmentation1.44755947
53MP0005310_abnormal_salivary_gland1.40935973
54MP0008469_abnormal_protein_level1.40132061
55MP0005058_abnormal_lysosome_morphology1.39256174
56MP0000609_abnormal_liver_physiology1.37850095
57MP0001533_abnormal_skeleton_physiology1.37728062
58MP0009643_abnormal_urine_homeostasis1.35809948
59MP0002006_tumorigenesis1.32321135
60MP0003453_abnormal_keratinocyte_physiol1.32116029
61MP0000689_abnormal_spleen_morphology1.30307662
62MP0002722_abnormal_immune_system1.29832600
63MP0001853_heart_inflammation1.27881324
64MP0000604_amyloidosis1.27782057
65MP0003172_abnormal_lysosome_physiology1.24935505
66MP0002429_abnormal_blood_cell1.22887259
67MP0002653_abnormal_ependyma_morphology1.18480073
68MP0005166_decreased_susceptibility_to1.18089180
69MP0010329_abnormal_lipoprotein_level1.17632738
70MP0005083_abnormal_biliary_tract1.16800188
71MP0009764_decreased_sensitivity_to1.15465874
72MP0002132_abnormal_respiratory_system1.15415923
73MP0000465_gastrointestinal_hemorrhage1.13251747
74MP0001851_eye_inflammation1.10444672
75MP0002136_abnormal_kidney_physiology1.09174694
76MP0005332_abnormal_amino_acid1.09159914
77MP0000703_abnormal_thymus_morphology1.06470729
78MP0003011_delayed_dark_adaptation1.03404617
79MP0000490_abnormal_crypts_of1.02013911
80MP0001348_abnormal_lacrimal_gland1.00887323
81MP0003195_calcinosis1.00326553
82MP0004019_abnormal_vitamin_homeostasis0.96126359
83MP0000858_altered_metastatic_potential0.95488749
84MP0005645_abnormal_hypothalamus_physiol0.95300980
85MP0000920_abnormal_myelination0.94634489
86MP0005584_abnormal_enzyme/coenzyme_acti0.93464099
87MP0001881_abnormal_mammary_gland0.93230120
88MP0001663_abnormal_digestive_system0.92579279
89MP0009763_increased_sensitivity_to0.92321441
90MP0009765_abnormal_xenobiotic_induced0.92131078
91MP0003183_abnormal_peptide_metabolism0.88751647
92MP0005023_abnormal_wound_healing0.88700819
93MP0005319_abnormal_enzyme/_coenzyme0.88593938
94MP0002118_abnormal_lipid_homeostasis0.88269871
95MP0005167_abnormal_blood-brain_barrier0.88264839
96MP0005390_skeleton_phenotype0.87377295
97MP0004264_abnormal_extraembryonic_tissu0.85961312
98MP0002998_abnormal_bone_remodeling0.84314667
99MP0003075_altered_response_to0.83672679
100MP0005381_digestive/alimentary_phenotyp0.82988591
101MP0005164_abnormal_response_to0.82627184
102MP0001216_abnormal_epidermal_layer0.80667903
103MP0005451_abnormal_body_composition0.80116176
104MP0002396_abnormal_hematopoietic_system0.80001118
105MP0005636_abnormal_mineral_homeostasis0.79637179
106MP0005165_increased_susceptibility_to0.79144662
107MP0001346_abnormal_lacrimal_gland0.77387964
108MP0010678_abnormal_skin_adnexa0.77026844
109MP0004883_abnormal_blood_vessel0.74730815
110MP0005084_abnormal_gallbladder_morpholo0.74544966
111MP0005397_hematopoietic_system_phenotyp0.74053065
112MP0001545_abnormal_hematopoietic_system0.74053065
113MP0003448_altered_tumor_morphology0.72524450
114MP0000249_abnormal_blood_vessel0.72498092
115MP0004782_abnormal_surfactant_physiolog0.72448947
116MP0001764_abnormal_homeostasis0.71853094
117MP0001765_abnormal_ion_homeostasis0.70966809
118MP0005075_abnormal_melanosome_morpholog0.70177104
119MP0000598_abnormal_liver_morphology0.69979173
120MP0000477_abnormal_intestine_morphology0.69433715
121MP0002019_abnormal_tumor_incidence0.68422412
122MP0003186_abnormal_redox_activity0.67527137
123MP0002837_dystrophic_cardiac_calcinosis0.66621329
124MP0002693_abnormal_pancreas_physiology0.62792236
125MP0002095_abnormal_skin_pigmentation0.60970905
126MP0003045_fibrosis0.55961627
127MP0003638_abnormal_response/metabolism_0.55570268
128MP0003795_abnormal_bone_structure0.53951230
129MP0006036_abnormal_mitochondrial_physio0.52544306

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.96158560
2Agammaglobulinemia (HP:0004432)3.87312045
3Mediastinal lymphadenopathy (HP:0100721)3.82899809
4Chronic otitis media (HP:0000389)3.80905442
5Elevated erythrocyte sedimentation rate (HP:0003565)3.76983555
6Petechiae (HP:0000967)3.61392289
7Abnormality of T cell number (HP:0011839)3.53223452
8Myositis (HP:0100614)3.52594105
9Abnormality of liposaccharide metabolism (HP:0010968)3.48793428
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.48793428
11Abnormality of glycolipid metabolism (HP:0010969)3.48793428
12Abnormal number of erythroid precursors (HP:0012131)3.43440021
13T lymphocytopenia (HP:0005403)3.40645989
14Nasal polyposis (HP:0100582)3.36683028
15Recurrent fungal infections (HP:0002841)3.27328226
16Recurrent sinusitis (HP:0011108)3.21504979
17Stomatitis (HP:0010280)3.21241774
18Abnormality of the nasal mucosa (HP:0000433)3.14445897
19Abnormality of cells of the erythroid lineage (HP:0012130)3.12832025
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.07417171
21Orchitis (HP:0100796)3.05279114
22Pustule (HP:0200039)3.02798355
23Recurrent bronchitis (HP:0002837)2.95273663
24Autoimmune thrombocytopenia (HP:0001973)2.92817468
25Obstructive lung disease (HP:0006536)2.91462677
26Chronic obstructive pulmonary disease (HP:0006510)2.91462677
27Retrobulbar optic neuritis (HP:0100654)2.90794638
28Optic neuritis (HP:0100653)2.90794638
29Cellulitis (HP:0100658)2.88256963
30Recurrent cutaneous fungal infections (HP:0011370)2.81084711
31Chronic mucocutaneous candidiasis (HP:0002728)2.81084711
32Abnormality of T cells (HP:0002843)2.79210410
33IgM deficiency (HP:0002850)2.78751710
34Interstitial pulmonary disease (HP:0006530)2.78662859
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.75320491
36Chronic diarrhea (HP:0002028)2.73991603
37Joint swelling (HP:0001386)2.72259779
38Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66425200
39Vasculitis (HP:0002633)2.65901412
40Abnormal mitochondria in muscle tissue (HP:0008316)2.63192993
41Mitochondrial inheritance (HP:0001427)2.63152262
42Keratoconjunctivitis (HP:0001096)2.62480597
43Recurrent viral infections (HP:0004429)2.61860601
44Acute necrotizing encephalopathy (HP:0006965)2.61640062
45Xanthomatosis (HP:0000991)2.61135341
46Increased IgE level (HP:0003212)2.60661033
47Recurrent skin infections (HP:0001581)2.60177088
48Deep venous thrombosis (HP:0002625)2.59356657
49Persistence of primary teeth (HP:0006335)2.57284628
50Intrahepatic cholestasis (HP:0001406)2.56937523
51Abnormality of macrophages (HP:0004311)2.56389671
52Severe combined immunodeficiency (HP:0004430)2.55892269
53Prolonged bleeding time (HP:0003010)2.51972539
54Purpura (HP:0000979)2.50188671
55Autoimmune hemolytic anemia (HP:0001890)2.48422306
56Combined immunodeficiency (HP:0005387)2.47912516
57Myocardial infarction (HP:0001658)2.45820742
58Inflammation of the large intestine (HP:0002037)2.45625141
593-Methylglutaconic aciduria (HP:0003535)2.44885406
60Abnormality of T cell physiology (HP:0011840)2.44595038
61Chronic sinusitis (HP:0011109)2.42732054
62Gastrointestinal infarctions (HP:0005244)2.39469974
63Increased density of long bones (HP:0006392)2.38932753
64Spontaneous hematomas (HP:0007420)2.38273190
65Restrictive lung disease (HP:0002091)2.37684005
66Pulmonary embolism (HP:0002204)2.37599188
67B lymphocytopenia (HP:0010976)2.37086539
68Gastrointestinal stroma tumor (HP:0100723)2.36956131
69Abnormality of B cell number (HP:0010975)2.36555574
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33681834
71Keratoconjunctivitis sicca (HP:0001097)2.33497636
72Gastrointestinal inflammation (HP:0004386)2.33323091
73Panhypogammaglobulinemia (HP:0003139)2.33147835
74Recurrent abscess formation (HP:0002722)2.32679839
75Arterial thrombosis (HP:0004420)2.32085591
76Recurrent bacterial skin infections (HP:0005406)2.31507350
77Colitis (HP:0002583)2.31364914
78Vacuolated lymphocytes (HP:0001922)2.30607670
79Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30460019
80Skin rash (HP:0000988)2.29052473
81Hydroxyprolinuria (HP:0003080)2.28449158
82Abnormality of proline metabolism (HP:0010907)2.28449158
83Gingival bleeding (HP:0000225)2.27047891
84Increased muscle lipid content (HP:0009058)2.26392938
85Hepatocellular necrosis (HP:0001404)2.24711330
86Axonal loss (HP:0003447)2.22813214
87Abnormality of the common coagulation pathway (HP:0010990)2.22447385
88Acute encephalopathy (HP:0006846)2.21888143
89Hypertensive crisis (HP:0100735)2.20860451
90Hepatic necrosis (HP:0002605)2.20126395
91Recurrent gram-negative bacterial infections (HP:0005420)2.18860179
92Abnormality of the prostate (HP:0008775)2.18423987
93Increased intramyocellular lipid droplets (HP:0012240)2.17644244
94Pulmonary infiltrates (HP:0002113)2.16745075
95Recurrent lower respiratory tract infections (HP:0002783)2.15635042
96Recurrent pneumonia (HP:0006532)2.12087991
97Progressive macrocephaly (HP:0004481)2.09919400
98Esophageal varix (HP:0002040)2.09874136
99Fatigue (HP:0012378)2.08802621
100Exertional dyspnea (HP:0002875)2.08329374
101Hypokalemic alkalosis (HP:0001949)2.06193571
102Abnormality of eosinophils (HP:0001879)2.05610782
103IgA deficiency (HP:0002720)2.04092605
104Vascular calcification (HP:0004934)2.04062794
105Leukocytosis (HP:0001974)2.03790199
106Neutropenia (HP:0001875)2.02700172
107Dysostosis multiplex (HP:0000943)2.02566886
108Encephalitis (HP:0002383)2.02558042
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02538481
110Eosinophilia (HP:0001880)2.01970561
111Hypergammaglobulinemia (HP:0010702)2.01856919
112Hemoptysis (HP:0002105)2.01508856
113Increased serum ferritin (HP:0003281)2.01384612
114Aplastic anemia (HP:0001915)2.01199323
115Generalized aminoaciduria (HP:0002909)2.01034696
116Abnormal pupillary function (HP:0007686)2.00615922
117Papilloma (HP:0012740)1.99554569
118Verrucae (HP:0200043)1.99554569
119Abnormality of transition element cation homeostasis (HP:0011030)1.99228934
120Hepatosplenomegaly (HP:0001433)1.98373523
121Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97971119
122Dicarboxylic aciduria (HP:0003215)1.97971119
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.97272269
124Lymphopenia (HP:0001888)1.96788692
125Abnormality of iron homeostasis (HP:0011031)1.96654486
126Systemic lupus erythematosus (HP:0002725)1.96452816
127Increased CSF lactate (HP:0002490)1.96296840
128Meningitis (HP:0001287)1.95613479
129Thrombophlebitis (HP:0004418)1.95343074
130Increased IgM level (HP:0003496)1.94927061
131Fat malabsorption (HP:0002630)1.94194724
132Urticaria (HP:0001025)1.94179395
133Abnormality of the pleura (HP:0002103)1.92502370
134Epistaxis (HP:0000421)1.92132347
135Increased cerebral lipofuscin (HP:0011813)1.90296528
136IgG deficiency (HP:0004315)1.88508909
137Complement deficiency (HP:0004431)1.88218191
138Amyloidosis (HP:0011034)1.87974756
139Polycythemia (HP:0001901)1.87390704
140Abnormal platelet function (HP:0011869)1.85349095
141Impaired platelet aggregation (HP:0003540)1.85349095
142Granulocytopenia (HP:0001913)1.84264560
143Abnormality of chloride homeostasis (HP:0011422)1.84150930
144Metabolic alkalosis (HP:0200114)1.83846933
145Ileus (HP:0002595)1.81914561
146Thrombocytosis (HP:0001894)1.80989855
147Emphysema (HP:0002097)1.80480472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.15175256
2VRK23.46361226
3EPHB13.34149081
4TXK3.15225513
5MAP3K143.14796167
6FGFR43.14590667
7RIPK42.65714489
8JAK32.50204893
9TYK22.47242499
10TBK12.46476732
11ZAP702.34272802
12ITK2.33934450
13MST42.33828694
14IKBKE2.12916976
15STK102.09099600
16ERN12.05515466
17VRK11.98262159
18JAK11.98243471
19TLK11.88660975
20TAOK31.79633539
21EPHA31.74692721
22TRIB31.74272587
23IKBKB1.67691999
24LRRK21.66968094
25GRK61.54303452
26CSK1.54214858
27PTK61.53893632
28SIK11.49218851
29ADRBK21.47647018
30IRAK31.44045755
31NLK1.42967399
32BTK1.42192810
33TAOK21.40515378
34KIT1.38991569
35TGFBR21.36726015
36GRK71.31520758
37CHUK1.27236127
38EEF2K1.26812061
39MAP3K31.25725801
40FES1.25673183
41LCK1.24516537
42MAP2K31.21738602
43MAP3K131.18987985
44TEC1.17880257
45FGFR31.16809403
46TNK21.14136221
47MAPK151.12968891
48TESK21.11157740
49KDR1.10526920
50SYK1.06827195
51MAP3K71.06288686
52JAK21.04421358
53CSF1R1.03339266
54CCNB11.00811448
55BLK1.00184859
56HCK0.99625601
57DAPK20.98960906
58STK390.98696055
59MAP2K20.97726640
60PRKCQ0.94606125
61BMPR20.93768563
62BCKDK0.92509982
63MST1R0.90689170
64NUAK10.87949911
65WNK40.87882715
66DAPK30.87443122
67ARAF0.86431435
68PRPF4B0.83281703
69ABL20.83265516
70MUSK0.83018514
71MAP3K100.82226004
72PKN20.81917232
73MOS0.80725152
74TRPM70.78090574
75IRAK40.77118752
76PASK0.77010565
77MAPKAPK30.75526560
78FGR0.74995582
79PRKCH0.70701684
80PIM10.67863484
81MAP4K20.67066179
82PRKG20.64682358
83MARK30.63388266
84NME10.63220008
85RPS6KA40.61446172
86MAP3K110.60960835
87PIM20.59175674
88MAPKAPK20.58518961
89LYN0.58295143
90ZAK0.56791363
91PKN10.56518038
92NME20.56049166
93TESK10.55812565
94STK160.55623181
95PIK3CG0.55483288
96GSK3A0.54730411
97TGFBR10.54441470
98FLT30.54129627
99MAP3K10.53640818
100PRKCD0.52234460
101PDGFRB0.51372976
102MAP3K20.51227717
103OXSR10.51221762
104PTK20.50854350
105EPHB20.50457494
106MAPKAPK50.48598997
107DAPK10.48526189
108IRAK10.48476080
109MET0.47341474
110GRK50.45911297
111MAPK110.45352074
112RIPK10.42802739
113TAOK10.42163092
114ADRBK10.41750255
115MAP3K80.41220407
116GRK10.40534177
117FGFR20.40194385
118MATK0.40164078
119INSR0.39690961
120RET0.39125851
121SMG10.38464898
122CLK10.38037243
123FRK0.37327653
124AURKA0.35933995
125PDK10.35030535
126MAP2K60.34962700
127BMX0.34903101
128RPS6KA60.34204862
129MAP3K50.33601560
130IGF1R0.33457239
131MAPK70.33087478
132MAPK40.32307257
133ABL10.31873109
134RPS6KC10.30763498
135RPS6KL10.30763498
136HIPK20.30706802
137LIMK10.30276363
138RPS6KA50.30270765
139EGFR0.30179603
140FYN0.28726615
141NEK90.27493652

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.09075086
2Type I diabetes mellitus_Homo sapiens_hsa049402.94155914
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.63536014
4Ribosome_Homo sapiens_hsa030102.42595917
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.22818133
6Oxidative phosphorylation_Homo sapiens_hsa001902.14546275
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.13307930
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.04257882
9T cell receptor signaling pathway_Homo sapiens_hsa046602.03698487
10Caffeine metabolism_Homo sapiens_hsa002321.88649057
11Leishmaniasis_Homo sapiens_hsa051401.88358151
12Allograft rejection_Homo sapiens_hsa053301.82317690
13Parkinsons disease_Homo sapiens_hsa050121.78420125
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.76705056
15Antigen processing and presentation_Homo sapiens_hsa046121.76402803
16Staphylococcus aureus infection_Homo sapiens_hsa051501.74980502
17Osteoclast differentiation_Homo sapiens_hsa043801.70586546
18Measles_Homo sapiens_hsa051621.67104704
19Graft-versus-host disease_Homo sapiens_hsa053321.64297957
20Systemic lupus erythematosus_Homo sapiens_hsa053221.62185648
21Histidine metabolism_Homo sapiens_hsa003401.56843684
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52312242
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50633038
24Sulfur metabolism_Homo sapiens_hsa009201.49077049
25Nitrogen metabolism_Homo sapiens_hsa009101.48080492
26Proteasome_Homo sapiens_hsa030501.43354036
27B cell receptor signaling pathway_Homo sapiens_hsa046621.42310634
28Autoimmune thyroid disease_Homo sapiens_hsa053201.38529596
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.35139899
30Hematopoietic cell lineage_Homo sapiens_hsa046401.34405923
31Toxoplasmosis_Homo sapiens_hsa051451.31152976
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28770228
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27053703
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26131565
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25733442
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25576384
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.22808383
38Tryptophan metabolism_Homo sapiens_hsa003801.21136786
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19681408
40TNF signaling pathway_Homo sapiens_hsa046681.17479787
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16271386
42ABC transporters_Homo sapiens_hsa020101.16249574
43Complement and coagulation cascades_Homo sapiens_hsa046101.15378603
44Fat digestion and absorption_Homo sapiens_hsa049751.13663603
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12672257
46Arginine biosynthesis_Homo sapiens_hsa002201.11330998
47Phagosome_Homo sapiens_hsa041451.08695707
48Fatty acid degradation_Homo sapiens_hsa000711.07852231
49Alzheimers disease_Homo sapiens_hsa050101.07128652
50Vitamin digestion and absorption_Homo sapiens_hsa049771.04842396
51Chemical carcinogenesis_Homo sapiens_hsa052041.03601708
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03164867
53Malaria_Homo sapiens_hsa051441.03080309
54Legionellosis_Homo sapiens_hsa051341.02679520
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00257769
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99910138
57Huntingtons disease_Homo sapiens_hsa050160.98403990
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97227609
59Shigellosis_Homo sapiens_hsa051310.96117222
60Pertussis_Homo sapiens_hsa051330.95461472
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93820312
62Influenza A_Homo sapiens_hsa051640.92983725
63Peroxisome_Homo sapiens_hsa041460.92029316
64Epstein-Barr virus infection_Homo sapiens_hsa051690.90976008
65Folate biosynthesis_Homo sapiens_hsa007900.90399422
66Hepatitis C_Homo sapiens_hsa051600.90381159
67Apoptosis_Homo sapiens_hsa042100.89005448
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.88352003
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88349863
70PPAR signaling pathway_Homo sapiens_hsa033200.87413106
71Viral myocarditis_Homo sapiens_hsa054160.87240461
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87196093
73Fatty acid elongation_Homo sapiens_hsa000620.86946812
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86716958
75Bile secretion_Homo sapiens_hsa049760.85411951
76Acute myeloid leukemia_Homo sapiens_hsa052210.85381135
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84781982
78African trypanosomiasis_Homo sapiens_hsa051430.84687316
79Chemokine signaling pathway_Homo sapiens_hsa040620.84196339
80Retinol metabolism_Homo sapiens_hsa008300.78530431
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78250806
82Lysosome_Homo sapiens_hsa041420.77717697
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77168888
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74226932
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73652395
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.71737273
87Homologous recombination_Homo sapiens_hsa034400.71623325
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71283870
89Sulfur relay system_Homo sapiens_hsa041220.71223339
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70321773
91Glutathione metabolism_Homo sapiens_hsa004800.69814637
92Steroid biosynthesis_Homo sapiens_hsa001000.69113903
93Pancreatic cancer_Homo sapiens_hsa052120.68335893
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.68335392
95Herpes simplex infection_Homo sapiens_hsa051680.67798658
96Tuberculosis_Homo sapiens_hsa051520.67449935
97Pyrimidine metabolism_Homo sapiens_hsa002400.65697010
98Prolactin signaling pathway_Homo sapiens_hsa049170.65090081
99Glycerolipid metabolism_Homo sapiens_hsa005610.64479899
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.64469049
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64221225
102Hepatitis B_Homo sapiens_hsa051610.63914238
103beta-Alanine metabolism_Homo sapiens_hsa004100.63355492
104Collecting duct acid secretion_Homo sapiens_hsa049660.63300939
105Selenocompound metabolism_Homo sapiens_hsa004500.60984854
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60771501
107Fatty acid metabolism_Homo sapiens_hsa012120.60412299
108Other glycan degradation_Homo sapiens_hsa005110.60190505
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58897678
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58042872
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58039746
112Asthma_Homo sapiens_hsa053100.57770891
113Starch and sucrose metabolism_Homo sapiens_hsa005000.57726705
114Base excision repair_Homo sapiens_hsa034100.56742007
115DNA replication_Homo sapiens_hsa030300.56492669
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56193480
117Rheumatoid arthritis_Homo sapiens_hsa053230.56106509
118Salmonella infection_Homo sapiens_hsa051320.56004949
119Chronic myeloid leukemia_Homo sapiens_hsa052200.55349163
120Arginine and proline metabolism_Homo sapiens_hsa003300.55059911
121HTLV-I infection_Homo sapiens_hsa051660.54143294
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.51127591
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50569653
124Propanoate metabolism_Homo sapiens_hsa006400.49893735
125Arachidonic acid metabolism_Homo sapiens_hsa005900.49884350
126Insulin resistance_Homo sapiens_hsa049310.48411466
127Renin-angiotensin system_Homo sapiens_hsa046140.46223838
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45393351
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45247942
130Mineral absorption_Homo sapiens_hsa049780.45097091
131Galactose metabolism_Homo sapiens_hsa000520.43220201
132Viral carcinogenesis_Homo sapiens_hsa052030.41729429
133RNA polymerase_Homo sapiens_hsa030200.40094282
134Mismatch repair_Homo sapiens_hsa034300.39750366
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38120199
136Protein export_Homo sapiens_hsa030600.30887716
137Fructose and mannose metabolism_Homo sapiens_hsa000510.30718022
138Platelet activation_Homo sapiens_hsa046110.24832976
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24566984
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20798350
141Cardiac muscle contraction_Homo sapiens_hsa042600.16805347
142Purine metabolism_Homo sapiens_hsa002300.16770150
143Bladder cancer_Homo sapiens_hsa052190.16382000
144Alcoholism_Homo sapiens_hsa050340.15511692

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