CD81

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.82873440
2central nervous system myelination (GO:0022010)9.82873440
3fatty acid elongation (GO:0030497)6.85258070
4myelination (GO:0042552)6.75978989
5axon ensheathment (GO:0008366)6.73478384
6ensheathment of neurons (GO:0007272)6.73478384
7negative regulation of neurotransmitter secretion (GO:0046929)5.11880525
8oligodendrocyte differentiation (GO:0048709)4.90237647
9long-chain fatty acid biosynthetic process (GO:0042759)4.79596333
10myelination in peripheral nervous system (GO:0022011)4.50405617
11peripheral nervous system axon ensheathment (GO:0032292)4.50405617
12barbed-end actin filament capping (GO:0051016)4.48571669
13astrocyte development (GO:0014002)4.28478459
14negative regulation of neurotransmitter transport (GO:0051589)4.25140738
15cholesterol biosynthetic process (GO:0006695)4.22741665
16myelin maintenance (GO:0043217)4.21125098
17glycerophospholipid catabolic process (GO:0046475)4.09713607
18creatine metabolic process (GO:0006600)4.04341438
19substantia nigra development (GO:0021762)4.02671618
20negative regulation of protein localization to cell surface (GO:2000009)4.01850514
21L-amino acid import (GO:0043092)3.90862190
22presynaptic membrane assembly (GO:0097105)3.90823131
23eye photoreceptor cell differentiation (GO:0001754)3.83280329
24photoreceptor cell differentiation (GO:0046530)3.83280329
25protein localization to endosome (GO:0036010)3.79720480
26asymmetric protein localization (GO:0008105)3.76357611
27response to redox state (GO:0051775)3.73003154
28presynaptic membrane organization (GO:0097090)3.72710918
29apical protein localization (GO:0045176)3.70835172
30regulation of early endosome to late endosome transport (GO:2000641)3.64390867
31sterol biosynthetic process (GO:0016126)3.64252529
32regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.60942959
33long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.60565113
34regulation of collateral sprouting (GO:0048670)3.58153612
35peptidyl-tyrosine autophosphorylation (GO:0038083)3.55835266
36negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.47300276
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.45498126
38import into cell (GO:0098657)3.40917458
39positive regulation of action potential (GO:0045760)3.37892579
40protein heterotrimerization (GO:0070208)3.37436614
41protein retention in ER lumen (GO:0006621)3.36625884
42L-serine transport (GO:0015825)3.36416491
43nucleotide transmembrane transport (GO:1901679)3.33338496
44amino acid import (GO:0043090)3.33171588
45basement membrane organization (GO:0071711)3.31639869
46stress fiber assembly (GO:0043149)3.30340386
47cell migration involved in heart development (GO:0060973)3.28842943
48cellular response to epinephrine stimulus (GO:0071872)3.24556884
49apoptotic cell clearance (GO:0043277)3.24260113
50endodermal cell differentiation (GO:0035987)3.21468908
51transmission of nerve impulse (GO:0019226)3.21166878
52long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.19014475
53fatty-acyl-CoA biosynthetic process (GO:0046949)3.17671440
54amyloid precursor protein metabolic process (GO:0042982)3.16542863
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.10651272
56regulation of extracellular matrix disassembly (GO:0010715)3.08187531
57isoprenoid biosynthetic process (GO:0008299)3.07860124
58response to lipoprotein particle (GO:0055094)3.06367471
59skin morphogenesis (GO:0043589)3.06301185
60response to epinephrine (GO:0071871)3.05729115
61positive regulation of oligodendrocyte differentiation (GO:0048714)3.04235459
62mannose metabolic process (GO:0006013)3.02049969
63vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.00466115
64response to methylmercury (GO:0051597)2.99338116
65vascular endothelial growth factor signaling pathway (GO:0038084)2.99115592
66neuron cell-cell adhesion (GO:0007158)2.95763842
67very long-chain fatty acid metabolic process (GO:0000038)2.94824725
68establishment of mitochondrion localization (GO:0051654)2.94737351
69positive regulation of receptor recycling (GO:0001921)2.93880512
70response to hepatocyte growth factor (GO:0035728)2.91457716
71cellular response to hepatocyte growth factor stimulus (GO:0035729)2.91457716
72cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.90946583
73tooth mineralization (GO:0034505)2.90317445
74cerebellar granule cell differentiation (GO:0021707)2.89551507
75membrane tubulation (GO:0097320)2.89045561
76fatty-acyl-CoA metabolic process (GO:0035337)2.88943899
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.88636224
78extracellular matrix assembly (GO:0085029)2.88104815
79negative regulation of axonogenesis (GO:0050771)2.87236736
80semaphorin-plexin signaling pathway (GO:0071526)2.87011114
81cerebral cortex radially oriented cell migration (GO:0021799)2.86774197
82positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86281564
83peripheral nervous system development (GO:0007422)2.85644577
84adherens junction assembly (GO:0034333)2.84837803
85glial cell development (GO:0021782)2.84448920
86limb bud formation (GO:0060174)2.83024905
87glycosylceramide metabolic process (GO:0006677)2.81413548
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.79864198
89extracellular fibril organization (GO:0043206)2.76305668
90serine transport (GO:0032329)2.75063034
91endothelial cell chemotaxis (GO:0035767)2.75017192
92membrane assembly (GO:0071709)2.74966053
93protein palmitoylation (GO:0018345)2.74837736
94leukocyte migration involved in inflammatory response (GO:0002523)2.74392175
95cell-substrate junction assembly (GO:0007044)2.73825035
96negative regulation of JUN kinase activity (GO:0043508)2.70723396
97glial cell migration (GO:0008347)2.70481552
98surfactant homeostasis (GO:0043129)2.69333304
99acyl-CoA biosynthetic process (GO:0071616)2.68719222
100thioester biosynthetic process (GO:0035384)2.68719222
101interleukin-6-mediated signaling pathway (GO:0070102)2.67440931
102nucleotide transport (GO:0006862)2.67384735
103collagen metabolic process (GO:0032963)2.66860926
104negative regulation of axon extension (GO:0030517)2.66034810
105axon development (GO:0061564)2.64386168
106amyloid precursor protein catabolic process (GO:0042987)2.63787847
107sodium ion export (GO:0071436)2.63615673
108fibril organization (GO:0097435)2.63186039
109embryo implantation (GO:0007566)2.63069642
110neurotransmitter uptake (GO:0001504)2.62797422
111adult walking behavior (GO:0007628)2.62131931
112neural nucleus development (GO:0048857)2.61787810
113collagen catabolic process (GO:0030574)2.61626209
114enteric nervous system development (GO:0048484)2.60766878
115* adhesion of symbiont to host cell (GO:0044650)2.60542322
116* virion attachment to host cell (GO:0019062)2.60542322
117positive regulation of extracellular matrix organization (GO:1903055)2.59098845
118response to lead ion (GO:0010288)2.58392046
119chondroitin sulfate catabolic process (GO:0030207)2.58322827
120keratan sulfate catabolic process (GO:0042340)2.58077263
121GPI anchor metabolic process (GO:0006505)2.56707848
122pinocytosis (GO:0006907)2.56691332
123venous blood vessel morphogenesis (GO:0048845)2.56203715
124glial cell differentiation (GO:0010001)2.56181100
125negative regulation of erythrocyte differentiation (GO:0045647)2.54733954
126GPI anchor biosynthetic process (GO:0006506)2.54600812
127cell volume homeostasis (GO:0006884)2.54494364
128cell-cell junction maintenance (GO:0045217)2.54040451
129neuron remodeling (GO:0016322)2.53750850
130extracellular matrix disassembly (GO:0022617)2.53612760
131cell-substrate adherens junction assembly (GO:0007045)2.52595511
132focal adhesion assembly (GO:0048041)2.52595511
133neuronal ion channel clustering (GO:0045161)2.52198993
134cortical actin cytoskeleton organization (GO:0030866)2.51880609
135hyaluronan catabolic process (GO:0030214)2.51312434
136* adhesion of symbiont to host (GO:0044406)2.50877227
137mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50532774
138multicellular organismal macromolecule metabolic process (GO:0044259)2.49442028
139regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49304212
140negative regulation of smooth muscle cell migration (GO:0014912)2.48289259
141magnesium ion transport (GO:0015693)2.47344068
142neurotransmitter catabolic process (GO:0042135)2.46802766
143dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46042760
144negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44028043
145cellular response to catecholamine stimulus (GO:0071870)2.43828688
146cellular response to monoamine stimulus (GO:0071868)2.43828688
147collagen fibril organization (GO:0030199)2.42799670
148hemidesmosome assembly (GO:0031581)2.42211307
149negative regulation of myoblast differentiation (GO:0045662)2.41996488
150glomerular filtration (GO:0003094)2.41786432
151multicellular organismal catabolic process (GO:0044243)2.41293474
152positive regulation of cellular amine metabolic process (GO:0033240)2.41140884
153Golgi to plasma membrane protein transport (GO:0043001)2.40615383
154activation of MAPKKK activity (GO:0000185)2.40569877
155response to monoamine (GO:0071867)2.39182662
156response to catecholamine (GO:0071869)2.39182662
157positive regulation of protein dephosphorylation (GO:0035307)2.38422287
158positive regulation of glial cell differentiation (GO:0045687)2.38414687
159negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.37814701
160negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.36787916
161ear development (GO:0043583)2.35822314
162regulation of membrane protein ectodomain proteolysis (GO:0051043)2.35097476
163apoptotic process involved in morphogenesis (GO:0060561)2.34539608
164low-density lipoprotein particle clearance (GO:0034383)2.34420070
165multicellular organismal metabolic process (GO:0044236)2.34138368
166cortical cytoskeleton organization (GO:0030865)2.33351902
167negative regulation of focal adhesion assembly (GO:0051895)2.32136945
168negative regulation of cell junction assembly (GO:1901889)2.32136945
169negative regulation of adherens junction organization (GO:1903392)2.32136945
170dermatan sulfate metabolic process (GO:0030205)2.32104194
171mannosylation (GO:0097502)2.32044482
172COPI coating of Golgi vesicle (GO:0048205)2.31240280
173Golgi transport vesicle coating (GO:0048200)2.31240280
174adenosine receptor signaling pathway (GO:0001973)2.31230282
175cellular response to thyroid hormone stimulus (GO:0097067)2.31155653
176Leydig cell differentiation (GO:0033327)2.31040740
177regulation of extracellular matrix organization (GO:1903053)2.30483074
178lateral sprouting from an epithelium (GO:0060601)2.28992446
179positive regulation of endothelial cell apoptotic process (GO:2000353)2.28988761
180epithelial cell-cell adhesion (GO:0090136)2.27297443
181positive regulation of blood vessel endothelial cell migration (GO:0043536)2.24776794
182negative regulation of fatty acid transport (GO:2000192)2.24102406
183atrioventricular valve morphogenesis (GO:0003181)2.23884192
184endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.23265155
185chondroitin sulfate biosynthetic process (GO:0030206)2.22561570
186type B pancreatic cell proliferation (GO:0044342)2.22210202
187regulation of glucose import in response to insulin stimulus (GO:2001273)2.21470702
188positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.21460419
189endocytic recycling (GO:0032456)2.20834692
190endothelial cell morphogenesis (GO:0001886)2.19353587
191dermatan sulfate biosynthetic process (GO:0030208)2.18321613
192cAMP biosynthetic process (GO:0006171)2.17562082
193glycosphingolipid catabolic process (GO:0046479)2.16980357
194regulation of cholesterol storage (GO:0010885)2.16229546
195UV protection (GO:0009650)2.16200642
196neuron projection extension involved in neuron projection guidance (GO:1902284)2.15072410
197axon extension involved in axon guidance (GO:0048846)2.15072410
198negative regulation of catenin import into nucleus (GO:0035414)2.14761692
199positive regulation of axon extension (GO:0045773)2.14445640
200amino sugar catabolic process (GO:0046348)2.12893112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse3.55638111
2GBX2_23144817_ChIP-Seq_PC3_Human3.39138459
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.38266795
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.10501922
5* LXR_22292898_ChIP-Seq_THP-1_Human2.85459225
6* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.56904235
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.54432249
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54058936
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52648566
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46041523
11* ELK3_25401928_ChIP-Seq_HUVEC_Human2.45599485
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36422298
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34152891
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23862415
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.21583655
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19131510
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13995414
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13244553
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11439195
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.10710226
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08973837
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08973837
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.06925252
24KDM2B_26808549_Chip-Seq_K562_Human2.02031165
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01754254
26* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.01637694
27RACK7_27058665_Chip-Seq_MCF-7_Human2.00788606
28CLOCK_20551151_ChIP-Seq_293T_Human1.96482384
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96020688
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93215606
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.92904147
32TAF15_26573619_Chip-Seq_HEK293_Human1.91630811
33AR_21572438_ChIP-Seq_LNCaP_Human1.91314792
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88985880
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88592647
36VDR_21846776_ChIP-Seq_THP-1_Human1.84082075
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83896906
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.83320543
39* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82993264
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82600194
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82006366
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79343253
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.78752483
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76776239
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75327802
46* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74527729
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73834490
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72140468
49* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.70742887
50DROSHA_22980978_ChIP-Seq_HELA_Human1.70122234
51* KDM2B_26808549_Chip-Seq_DND41_Human1.69748910
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69306121
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69184130
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67612135
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.66398372
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.64187763
57* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63601649
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60762146
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58193099
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56503922
61EZH2_22144423_ChIP-Seq_EOC_Human1.55984343
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55753546
63ER_23166858_ChIP-Seq_MCF-7_Human1.52568382
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.51917751
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50899788
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49812115
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.48323801
68ZNF263_19887448_ChIP-Seq_K562_Human1.46286218
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44487580
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44487580
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.43976786
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42602896
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.41050973
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38900221
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.38865828
76TCF7_22412390_ChIP-Seq_EML_Mouse1.37773646
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36893620
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36279462
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35714235
80SMC4_20622854_ChIP-Seq_HELA_Human1.35313940
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.35038646
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32703369
83CTCF_27219007_Chip-Seq_Bcells_Human1.32343566
84VDR_22108803_ChIP-Seq_LS180_Human1.29855551
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29500358
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29386708
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28917220
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.28852386
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26843099
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26370411
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25838907
92SMC1_22415368_ChIP-Seq_MEFs_Mouse1.25428053
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24909761
94TBX20_22328084_ChIP-Seq_HEART_Mouse1.24733005
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.24733005
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24671329
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.24613801
98P300_19829295_ChIP-Seq_ESCs_Human1.24434398
99* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23704075
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23065944
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.22916485
102SMC3_22415368_ChIP-Seq_MEFs_Mouse1.22819167
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22655166
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22176593
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21416616
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21376463
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20999028
108P68_20966046_ChIP-Seq_HELA_Human1.19862481
109TP53_22127205_ChIP-Seq_IMR90_Human1.18668581
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17739730
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17409735
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15905768
113TET1_21490601_ChIP-Seq_MESCs_Mouse1.15443843
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15197739
115VDR_24763502_ChIP-Seq_THP-1_Human1.13348824
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13071708
117EOMES_21245162_ChIP-Seq_HESCs_Human1.12309024
118CREB1_26743006_Chip-Seq_LNCaP_Human1.12163690
119ESR1_21235772_ChIP-Seq_MCF-7_Human1.09916970
120* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09908587
121FUS_26573619_Chip-Seq_HEK293_Human1.09869502
122SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08729729
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06859420
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04645035
125* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04207904
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03924369
127IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03247616
128UBF1/2_26484160_Chip-Seq_HMECs_Human1.03143918
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02834160
130TP53_18474530_ChIP-ChIP_U2OS_Human1.02821424
131* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01667923
132NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01451922
133TP63_22573176_ChIP-Seq_HFKS_Human1.01124449
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99862870
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99362144
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99081175
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98756603
138* TP53_23651856_ChIP-Seq_MEFs_Mouse0.98604460
139EGR1_19374776_ChIP-ChIP_THP-1_Human0.96874478
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95674696
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95512168
142* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94857525
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94712862
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.94262825
145STAT3_23295773_ChIP-Seq_U87_Human0.94149333
146MYC_22102868_ChIP-Seq_BL_Human0.93857977
147SMAD4_21799915_ChIP-Seq_A2780_Human0.93444627
148RING1B_27294783_Chip-Seq_ESCs_Mouse0.92997201
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92936069
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92522900
151REST_21632747_ChIP-Seq_MESCs_Mouse0.92114683
152TAL1_26923725_Chip-Seq_HPCs_Mouse0.91607602
153NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90962153
154GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90345860
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89945313
156HTT_18923047_ChIP-ChIP_STHdh_Human0.89538776
157ESR2_21235772_ChIP-Seq_MCF-7_Human0.89454280
158RARB_27405468_Chip-Seq_BRAIN_Mouse0.87895476
159AHR_22903824_ChIP-Seq_MCF-7_Human0.87464416
160MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86702774
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85410007
162EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85281869
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84512793
164OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83596661
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.83575893
166PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83093817
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82451623
168ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82135160
169TCF4_23295773_ChIP-Seq_U87_Human0.81562997
170TP53_16413492_ChIP-PET_HCT116_Human0.81208694
171SOX2_21211035_ChIP-Seq_LN229_Gbm0.81092949
172RUNX2_22187159_ChIP-Seq_PCA_Human0.79944086
173CMYC_18555785_Chip-Seq_ESCs_Mouse0.79584056
174PRDM14_20953172_ChIP-Seq_ESCs_Human0.79582815
175RING1B_27294783_Chip-Seq_NPCs_Mouse0.79097714
176LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78934508
177TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78874794
178REST_18959480_ChIP-ChIP_MESCs_Mouse0.78379972
179ERG_21242973_ChIP-ChIP_JURKAT_Human0.78247528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.13422730
2MP0003705_abnormal_hypodermis_morpholog4.54695260
3MP0003690_abnormal_glial_cell4.01025178
4MP0003950_abnormal_plasma_membrane3.32165802
5MP0005171_absent_coat_pigmentation3.24146708
6MP0003136_yellow_coat_color3.11604891
7MP0005257_abnormal_intraocular_pressure3.00855557
8MP0009840_abnormal_foam_cell2.97017315
9MP0004885_abnormal_endolymph2.93836345
10MP0003880_abnormal_central_pattern2.92807396
11MP0005275_abnormal_skin_tensile2.74473122
12MP0003329_amyloid_beta_deposits2.73403727
13MP0004270_analgesia2.62620465
14* MP0003634_abnormal_glial_cell2.40321783
15MP0001485_abnormal_pinna_reflex2.21703431
16MP0004742_abnormal_vestibular_system2.21061079
17MP0001529_abnormal_vocalization2.19015913
18MP0001486_abnormal_startle_reflex2.16802621
19MP0008438_abnormal_cutaneous_collagen2.12914977
20MP0002272_abnormal_nervous_system2.12716117
21MP0003566_abnormal_cell_adhesion2.02282966
22MP0004142_abnormal_muscle_tone2.00837641
23MP0010368_abnormal_lymphatic_system1.98004278
24MP0002064_seizures1.94387747
25MP0001849_ear_inflammation1.94271128
26MP0000751_myopathy1.82186147
27MP0003091_abnormal_cell_migration1.81866146
28MP0004510_myositis1.81574687
29MP0005023_abnormal_wound_healing1.80252959
30MP0003632_abnormal_nervous_system1.76568219
31MP0005670_abnormal_white_adipose1.70464883
32MP0000462_abnormal_digestive_system1.70320651
33MP0009046_muscle_twitch1.66223869
34MP0000343_altered_response_to1.66190951
35MP0003172_abnormal_lysosome_physiology1.65247306
36* MP0001905_abnormal_dopamine_level1.64715137
37MP0002229_neurodegeneration1.64667875
38MP0003191_abnormal_cellular_cholesterol1.64372910
39MP0005409_darkened_coat_color1.63851213
40MP0004134_abnormal_chest_morphology1.61601368
41MP0002877_abnormal_melanocyte_morpholog1.59971391
42MP0000767_abnormal_smooth_muscle1.58775483
43MP0004272_abnormal_basement_membrane1.56802717
44MP0009384_cardiac_valve_regurgitation1.56060539
45MP0004859_abnormal_synaptic_plasticity1.55819905
46MP0005623_abnormal_meninges_morphology1.54291485
47MP0003300_gastrointestinal_ulcer1.51026227
48MP0005508_abnormal_skeleton_morphology1.48366641
49MP0003303_peritoneal_inflammation1.47768377
50* MP0000778_abnormal_nervous_system1.46180171
51MP0002998_abnormal_bone_remodeling1.43652888
52MP0000604_amyloidosis1.42926282
53MP0005551_abnormal_eye_electrophysiolog1.42761888
54MP0004147_increased_porphyrin_level1.40875115
55MP0003453_abnormal_keratinocyte_physiol1.40448716
56MP0002060_abnormal_skin_morphology1.37746887
57MP0002295_abnormal_pulmonary_circulatio1.37565420
58MP0002734_abnormal_mechanical_nocicepti1.36997879
59MP0003635_abnormal_synaptic_transmissio1.35528811
60MP0003806_abnormal_nucleotide_metabolis1.34648951
61MP0002896_abnormal_bone_mineralization1.34562018
62MP0000566_synostosis1.32039230
63MP0001440_abnormal_grooming_behavior1.31978982
64MP0008260_abnormal_autophagy1.30969790
65MP0005423_abnormal_somatic_nervous1.30406618
66MP0005666_abnormal_adipose_tissue1.28746395
67MP0005410_abnormal_fertilization1.27245368
68* MP0009745_abnormal_behavioral_response1.26473289
69MP0003631_nervous_system_phenotype1.25356600
70MP0010030_abnormal_orbit_morphology1.24760892
71MP0004043_abnormal_pH_regulation1.22863990
72MP0001299_abnormal_eye_distance/1.22797452
73MP0005451_abnormal_body_composition1.22668456
74MP0005375_adipose_tissue_phenotype1.21949018
75MP0001661_extended_life_span1.20476836
76MP0000383_abnormal_hair_follicle1.17708776
77MP0005165_increased_susceptibility_to1.15281709
78MP0001963_abnormal_hearing_physiology1.15140204
79MP0003828_pulmonary_edema1.14095021
80* MP0002882_abnormal_neuron_morphology1.13880643
81MP0000955_abnormal_spinal_cord1.12783798
82MP0005058_abnormal_lysosome_morphology1.12342981
83MP0002572_abnormal_emotion/affect_behav1.11896535
84MP0002090_abnormal_vision1.11429996
85MP0009278_abnormal_bone_marrow1.09111291
86MP0001533_abnormal_skeleton_physiology1.09076165
87MP0010678_abnormal_skin_adnexa1.08884364
88MP0003633_abnormal_nervous_system1.07970327
89MP0003879_abnormal_hair_cell1.07709936
90MP0005390_skeleton_phenotype1.06672838
91MP0009780_abnormal_chondrocyte_physiolo1.06187417
92MP0000747_muscle_weakness1.04412129
93MP0002067_abnormal_sensory_capabilities1.03375368
94MP0002254_reproductive_system_inflammat1.02026594
95MP0000003_abnormal_adipose_tissue1.01926901
96MP0008569_lethality_at_weaning1.01575645
97MP0002752_abnormal_somatic_nervous1.01277072
98* MP0002066_abnormal_motor_capabilities/c1.00337133
99MP0000858_altered_metastatic_potential0.99561291
100MP0003448_altered_tumor_morphology0.96646857
101MP0001348_abnormal_lacrimal_gland0.95629458
102MP0004036_abnormal_muscle_relaxation0.94470956
103MP0009379_abnormal_foot_pigmentation0.94013386
104MP0005195_abnormal_posterior_eye0.93610820
105MP0002249_abnormal_larynx_morphology0.93428520
106MP0002089_abnormal_postnatal_growth/wei0.93025273
107MP0004924_abnormal_behavior0.92519969
108MP0005386_behavior/neurological_phenoty0.92519969
109MP0003011_delayed_dark_adaptation0.91455236
110MP0008004_abnormal_stomach_pH0.91224122
111MP0000733_abnormal_muscle_development0.88841884
112MP0001958_emphysema0.88322714
113MP0002933_joint_inflammation0.88168043
114MP0006138_congestive_heart_failure0.88148198
115MP0002063_abnormal_learning/memory/cond0.88027482
116MP0005167_abnormal_blood-brain_barrier0.87224200
117MP0000681_abnormal_thyroid_gland0.87203890
118MP0001177_atelectasis0.86056339
119MP0005503_abnormal_tendon_morphology0.85584927
120MP0003436_decreased_susceptibility_to0.85210143
121MP0005166_decreased_susceptibility_to0.84796345
122MP0006082_CNS_inflammation0.84349424
123MP0005646_abnormal_pituitary_gland0.84335656
124MP0001970_abnormal_pain_threshold0.84171147
125MP0006054_spinal_hemorrhage0.83790435
126MP0000026_abnormal_inner_ear0.83731581
127MP0000762_abnormal_tongue_morphology0.82481491
128MP0003938_abnormal_ear_development0.81885092
129MP0004185_abnormal_adipocyte_glucose0.81262274
130MP0005253_abnormal_eye_physiology0.81235833
131MP0003195_calcinosis0.80677298
132MP0003137_abnormal_impulse_conducting0.80608032
133MP0002971_abnormal_brown_adipose0.80325110
134MP0000759_abnormal_skeletal_muscle0.80194312
135MP0001879_abnormal_lymphatic_vessel0.80187332
136MP0004858_abnormal_nervous_system0.79527122
137MP0001346_abnormal_lacrimal_gland0.79403703
138MP0002139_abnormal_hepatobiliary_system0.78663391
139MP0004947_skin_inflammation0.78452740
140MP0004381_abnormal_hair_follicle0.78342786
141MP0003075_altered_response_to0.77677222
142MP0000678_abnormal_parathyroid_gland0.77434306
143MP0001243_abnormal_dermal_layer0.77003650
144MP0002108_abnormal_muscle_morphology0.76998419
145MP0004130_abnormal_muscle_cell0.76579089
146MP0000249_abnormal_blood_vessel0.75460219
147MP0005645_abnormal_hypothalamus_physiol0.75278217
148MP0003279_aneurysm0.74630348
149MP0000749_muscle_degeneration0.74288570
150MP0000372_irregular_coat_pigmentation0.74131421
151MP0005595_abnormal_vascular_smooth0.74043652
152MP0001502_abnormal_circadian_rhythm0.73433135
153MP0002733_abnormal_thermal_nociception0.73364357
154MP0009053_abnormal_anal_canal0.72748207
155MP0005330_cardiomyopathy0.72421663
156MP0001542_abnormal_bone_strength0.72358056
157MP0002133_abnormal_respiratory_system0.71890889
158MP0005388_respiratory_system_phenotype0.71890889
159MP0009250_abnormal_appendicular_skeleto0.71794600
160MP0003283_abnormal_digestive_organ0.71555516
161MP0001851_eye_inflammation0.70360275
162MP0005408_hypopigmentation0.70020441
163MP0003937_abnormal_limbs/digits/tail_de0.69853141
164MP0000647_abnormal_sebaceous_gland0.69720078
165MP0005164_abnormal_response_to0.69536558
166MP0000013_abnormal_adipose_tissue0.69404067
167MP0002736_abnormal_nociception_after0.67592772
168MP0002796_impaired_skin_barrier0.66705632
169MP0001614_abnormal_blood_vessel0.66378994
170MP0005076_abnormal_cell_differentiation0.64545928
171MP0004087_abnormal_muscle_fiber0.64120434

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.19189018
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.35060588
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.35060588
4Protrusio acetabuli (HP:0003179)5.30204887
5Sensory axonal neuropathy (HP:0003390)4.79960797
6Parakeratosis (HP:0001036)4.38420985
7Cerebral inclusion bodies (HP:0100314)4.23968042
8Abnormality of the corticospinal tract (HP:0002492)3.77643413
9Abnormality of liposaccharide metabolism (HP:0010968)3.76981351
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.76981351
11Abnormality of glycolipid metabolism (HP:0010969)3.76981351
12Peripheral hypomyelination (HP:0007182)3.72494776
13Systemic lupus erythematosus (HP:0002725)3.67791783
14Vertebral compression fractures (HP:0002953)3.64689254
15Cerebral aneurysm (HP:0004944)3.34400472
16Supranuclear gaze palsy (HP:0000605)3.25583913
17Aplasia involving bones of the upper limbs (HP:0009823)3.21791974
18Aplasia of the phalanges of the hand (HP:0009802)3.21791974
19Aplasia involving bones of the extremities (HP:0009825)3.21791974
20Aortic aneurysm (HP:0004942)3.14762121
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.14361041
22Intention tremor (HP:0002080)3.13018637
23Abnormal auditory evoked potentials (HP:0006958)3.12190114
24Shallow orbits (HP:0000586)3.09232245
25Bladder diverticulum (HP:0000015)3.08647657
26Cerebral hypomyelination (HP:0006808)3.05033702
27Increased variability in muscle fiber diameter (HP:0003557)3.04498837
28Spastic paraparesis (HP:0002313)3.04173143
29Vascular tortuosity (HP:0004948)3.04043887
30Akinesia (HP:0002304)3.02479345
31Alacrima (HP:0000522)3.00725690
32Ankle contracture (HP:0006466)2.98721048
33Cervical subluxation (HP:0003308)2.95234925
34Premature skin wrinkling (HP:0100678)2.92011937
35Spinal rigidity (HP:0003306)2.91625268
36Dysostosis multiplex (HP:0000943)2.88193593
37Aortic dissection (HP:0002647)2.86803385
38Abnormality of glycolysis (HP:0004366)2.86652411
39Increased serum pyruvate (HP:0003542)2.86652411
40Abnormality of complement system (HP:0005339)2.83912571
41Complement deficiency (HP:0004431)2.83147187
42Spastic gait (HP:0002064)2.81633245
43Atrophic scars (HP:0001075)2.81332889
44Retinal dysplasia (HP:0007973)2.80607484
45Onion bulb formation (HP:0003383)2.76764078
46Leukodystrophy (HP:0002415)2.76541938
47Pheochromocytoma (HP:0002666)2.76262578
48Hypoplastic pelvis (HP:0008839)2.74478436
49Fragile skin (HP:0001030)2.72706837
50Humeroradial synostosis (HP:0003041)2.72308110
51Synostosis involving the elbow (HP:0003938)2.72308110
52Clumsiness (HP:0002312)2.70146315
53Obstructive sleep apnea (HP:0002870)2.69848187
54Axonal loss (HP:0003447)2.68451316
55Megalencephaly (HP:0001355)2.67187724
56Dysmetria (HP:0001310)2.66217673
57Coronal craniosynostosis (HP:0004440)2.65316823
58Genu recurvatum (HP:0002816)2.61483838
59Split foot (HP:0001839)2.59035141
60Arterial tortuosity (HP:0005116)2.57310867
61Cerebral hemorrhage (HP:0001342)2.56571544
62Achilles tendon contracture (HP:0001771)2.54629665
63Increased circulating renin level (HP:0000848)2.54517984
64Infantile muscular hypotonia (HP:0008947)2.53989415
65Nuclear cataract (HP:0100018)2.53962289
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.52024571
67Blue sclerae (HP:0000592)2.51385406
68Neuroendocrine neoplasm (HP:0100634)2.50710919
69Distal upper limb amyotrophy (HP:0007149)2.50579854
70Upper limb amyotrophy (HP:0009129)2.50579854
71Type 1 muscle fiber predominance (HP:0003803)2.48755409
72Abnormality of skeletal muscle fiber size (HP:0012084)2.46771414
73Wormian bones (HP:0002645)2.46649074
74Mitral regurgitation (HP:0001653)2.46040574
75Hyperacusis (HP:0010780)2.44006565
76Hypoplastic left heart (HP:0004383)2.43524359
77Anteriorly placed anus (HP:0001545)2.42701015
78Increased connective tissue (HP:0009025)2.42112850
79Turricephaly (HP:0000262)2.41729573
80White forelock (HP:0002211)2.40453880
81Abnormality of polysaccharide metabolism (HP:0011012)2.40326748
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40326748
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40326748
84Thickened helices (HP:0000391)2.39693984
85Slow saccadic eye movements (HP:0000514)2.39398707
86Patchy hypopigmentation of hair (HP:0011365)2.37263471
87Urinary glycosaminoglycan excretion (HP:0003541)2.36518182
88Mucopolysacchariduria (HP:0008155)2.36518182
89Morphological abnormality of the inner ear (HP:0011390)2.36374622
90Soft skin (HP:0000977)2.35180303
91Increased cerebral lipofuscin (HP:0011813)2.34854571
92Scanning speech (HP:0002168)2.34057448
93Paraparesis (HP:0002385)2.32971199
94Congenital ichthyosiform erythroderma (HP:0007431)2.30142768
95Dilatation of the ascending aorta (HP:0005111)2.29937681
96Abnormality of the Achilles tendon (HP:0005109)2.27727429
97Adrenal hypoplasia (HP:0000835)2.27488853
98Abnormality of dentin (HP:0010299)2.27289049
99Decreased lacrimation (HP:0000633)2.27084062
100Aneurysm (HP:0002617)2.26596518
101Stridor (HP:0010307)2.23874096
102Joint stiffness (HP:0001387)2.22512477
103Methylmalonic acidemia (HP:0002912)2.21978985
104Glomerulonephritis (HP:0000099)2.18800433
105Renal Fanconi syndrome (HP:0001994)2.17569802
106Neonatal short-limb short stature (HP:0008921)2.16946836
107Distal lower limb muscle weakness (HP:0009053)2.15372672
108Hypokalemic alkalosis (HP:0001949)2.14072055
109Mildly elevated creatine phosphokinase (HP:0008180)2.13942101
110Follicular hyperkeratosis (HP:0007502)2.13385400
111Hypoplasia of the iris (HP:0007676)2.11502911
112Partial duplication of thumb phalanx (HP:0009944)2.10272173
113Hyperextensible skin (HP:0000974)2.09741015
114Autoamputation (HP:0001218)2.09428009
115Hepatosplenomegaly (HP:0001433)2.07854114
116Atonic seizures (HP:0010819)2.06903452
117Ulnar bowing (HP:0003031)2.05635788
118Asymmetric septal hypertrophy (HP:0001670)2.04776680
119Slender build (HP:0001533)2.04765574
120Metabolic alkalosis (HP:0200114)2.04740685
121Biconcave vertebral bodies (HP:0004586)2.02933152
122Absent septum pellucidum (HP:0001331)2.02615338
123Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02206032
124Hypomagnesemia (HP:0002917)2.02153171
125Abnormality of the middle phalanges of the toes (HP:0010183)2.02083870
126Hand muscle atrophy (HP:0009130)2.01410194
127Thin bony cortex (HP:0002753)2.00649907
128Mitral valve prolapse (HP:0001634)1.99548280
129Bowel diverticulosis (HP:0005222)1.99343150
130Spondylolisthesis (HP:0003302)1.98488840
131Abnormality of the nasal mucosa (HP:0000433)1.97929316
132Broad metatarsal (HP:0001783)1.97761273
133Lower limb muscle weakness (HP:0007340)1.97487043
134Generalized amyotrophy (HP:0003700)1.96497500
135Disproportionate tall stature (HP:0001519)1.96040799
136Hyperparathyroidism (HP:0000843)1.95214883
137Myelomeningocele (HP:0002475)1.93464158
138Elbow flexion contracture (HP:0002987)1.91068732
139Joint laxity (HP:0001388)1.89784859
140Hypoplastic heart (HP:0001961)1.89460615
141Abolished electroretinogram (ERG) (HP:0000550)1.88448562
142Barrel-shaped chest (HP:0001552)1.87558454
143Loss of speech (HP:0002371)1.87009146
144Premature rupture of membranes (HP:0001788)1.86994363
145Insomnia (HP:0100785)1.86160305
146Partial duplication of the phalanx of hand (HP:0009999)1.84366123
147Diminished movement (HP:0002374)1.84363112
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.84135052
149Osteolytic defects of the hand bones (HP:0009699)1.84135052
150Short nail (HP:0001799)1.83761722
151Partial agenesis of the corpus callosum (HP:0001338)1.83411025
152Hypoventilation (HP:0002791)1.83035691
153Vaginal atresia (HP:0000148)1.83024503
154Long toe (HP:0010511)1.82880235
155Muscle fiber splitting (HP:0003555)1.82447837
156Polygenic inheritance (HP:0010982)1.82121165
157Mixed hearing impairment (HP:0000410)1.79922494
158Acute necrotizing encephalopathy (HP:0006965)1.79592801
159Natal tooth (HP:0000695)1.77566459
160CNS hypomyelination (HP:0003429)1.77402886
161Ankle clonus (HP:0011448)1.77346706
162Gowers sign (HP:0003391)1.76846344
163Insidious onset (HP:0003587)1.76787102
164Termporal pattern (HP:0011008)1.76787102
165Generalized myoclonic seizures (HP:0002123)1.74978564
166Relative macrocephaly (HP:0004482)1.73693763
167Nephritis (HP:0000123)1.73513842
168Anomalous pulmonary venous return (HP:0010772)1.73017401
169Back pain (HP:0003418)1.72486758
170Aortic regurgitation (HP:0001659)1.71656188
171Atelectasis (HP:0100750)1.71622854
172Mitral stenosis (HP:0001718)1.71287784
173J-shaped sella turcica (HP:0002680)1.71251245
174Cupped ear (HP:0000378)1.70000233
175* Emphysema (HP:0002097)1.69641324
176Poor speech (HP:0002465)1.69580690
177Genital tract atresia (HP:0001827)1.69133010
178Venous abnormality (HP:0002624)1.68333352
179Urinary incontinence (HP:0000020)1.67123405
180Bell-shaped thorax (HP:0001591)1.66903685
181Short hallux (HP:0010109)1.66664554
182Esophageal atresia (HP:0002032)1.65601563
183Hypercortisolism (HP:0001578)1.65241703
184Increased neuronal autofluorescent lipopigment (HP:0002074)1.64642047
185Type II lissencephaly (HP:0007260)1.64162165
186Amyloidosis (HP:0011034)1.63375645
187Overgrowth (HP:0001548)1.63320659
188Interstitial pulmonary disease (HP:0006530)1.63207844
189Aortic valve stenosis (HP:0001650)1.62990209
190Septo-optic dysplasia (HP:0100842)1.61902393
191Myokymia (HP:0002411)1.61224999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.18446619
2OXSR14.60694289
3TNIK3.79959626
4TRIB33.73653794
5ERN13.30773676
6RIPK13.25022341
7BCR2.96693014
8EPHB12.89990082
9PRPF4B2.66372312
10WNK42.57973482
11PDGFRA2.41996934
12CDK192.38335789
13SMG12.36131493
14MET2.31503086
15PKN12.28809006
16SIK12.26676706
17NEK62.26405593
18PBK2.13685158
19ICK2.03787997
20FGFR21.97636943
21TESK11.95699756
22CDC42BPA1.93114051
23PRKD31.89078833
24WNK11.76607463
25LIMK11.76388578
26CSNK1G31.75999465
27TGFBR21.75920987
28IRAK31.70950672
29LATS21.66895489
30ROCK21.65912760
31TTN1.65620033
32NME21.63571336
33EEF2K1.63094641
34CSNK1A1L1.62109064
35MAPKAPK51.53396098
36UHMK11.45446770
37CASK1.43126365
38PTK21.41042351
39PRKD21.37479119
40NTRK11.35567785
41CSNK1G11.35401800
42MST41.35377212
43FGR1.34737890
44ABL21.33697210
45MAPK151.29048864
46CSNK1G21.28028168
47RPS6KA21.25794762
48TAOK21.25733992
49CAMK2B1.24495463
50PHKG11.22542143
51PHKG21.22542143
52CAMK2D1.21160704
53MAP3K111.19934489
54EPHA41.18025929
55PAK61.16988227
56MAP3K31.15976960
57PIM21.15337874
58DAPK31.13640437
59PAK31.12986844
60FGFR41.12652891
61PAK41.12297859
62KSR21.10428406
63CLK11.09041544
64TYRO31.03215131
65NEK91.02210963
66PAK21.01759039
67MUSK0.95455405
68ARAF0.94703621
69TBK10.93799451
70CAMK2G0.92846991
71SGK4940.91864942
72SGK2230.91864942
73PKN20.89378100
74CDK140.86897019
75TIE10.86726327
76MAP3K10.85500916
77ERBB40.84130742
78LMTK20.83389388
79PRKCQ0.81651060
80PRKG20.81264529
81MAPK120.81076578
82MAP2K30.80888509
83PNCK0.80522613
84MTOR0.80255799
85EPHA20.79338761
86BRAF0.78749273
87RPS6KL10.78208427
88RPS6KC10.78208427
89CAMK2A0.77870006
90TYK20.76705603
91PRKCE0.75035407
92NTRK20.74085512
93CDK150.70984370
94CDK50.70443524
95MAPKAPK30.70258755
96TESK20.69654496
97PTK60.69501814
98MAP3K60.68958049
99TAOK10.68376312
100PIK3CA0.68274056
101STK380.68018507
102ROCK10.67928392
103CDK180.65742590
104GRK70.65516036
105MAPK40.65309020
106MAPK130.65292273
107PRKD10.65118768
108IRAK20.63754371
109CDK11A0.62715553
110BMPR1B0.60615948
111DYRK20.59931671
112ILK0.59128271
113LRRK20.58497639
114MAPK70.57894714
115MARK20.57874093
116CAMKK10.57805096
117PRKCH0.56855977
118MAP3K90.56220056
119RPS6KA60.55889730
120FYN0.55875708
121HIPK20.54567100
122IRAK10.54154360
123GRK50.53079452
124TRPM70.52283994
125CAMK1D0.50000301
126MAP3K130.49930708
127MARK10.49525330
128CDK120.48153302
129MYLK0.47779441
130PRKG10.47728701
131ZAP700.46136971
132PDPK10.45780403
133MOS0.44556771
134ADRBK20.43754288
135PTK2B0.42224666
136MAP3K80.41203805
137RET0.40727372
138NTRK30.40400675
139PDGFRB0.40366549
140KIT0.40261816
141OBSCN0.40177218
142MAP2K20.39808835
143BMX0.38981496
144MAP3K140.38766003
145INSR0.38197206
146KDR0.38060628
147STK160.38019486
148JAK10.37731469
149PRKACB0.37513237
150DDR20.36466386
151PDK10.34423981
152EPHB20.34003771
153CSNK1D0.33951601
154FES0.33527023
155CSNK1A10.31015508
156PRKACA0.30717143
157GSK3A0.29243942
158ADRBK10.29170558
159DMPK0.28490631
160CAMK1G0.27592744
161EPHA30.26115702
162WNK30.25967271
163CSF1R0.25846195
164SRC0.25378763
165GRK10.24425741
166PAK10.24090047

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.47028552
2Steroid biosynthesis_Homo sapiens_hsa001004.32122141
3Fatty acid elongation_Homo sapiens_hsa000624.23830905
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.42118694
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.96747627
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.81646886
7Ether lipid metabolism_Homo sapiens_hsa005652.69714214
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.68514795
9Oxidative phosphorylation_Homo sapiens_hsa001902.47587038
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.35094040
11Sulfur metabolism_Homo sapiens_hsa009201.95049597
12Protein export_Homo sapiens_hsa030601.85293229
13Sphingolipid metabolism_Homo sapiens_hsa006001.78537059
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77063549
15Parkinsons disease_Homo sapiens_hsa050121.75568822
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74032565
17Axon guidance_Homo sapiens_hsa043601.73171417
18Butanoate metabolism_Homo sapiens_hsa006501.63175410
19Fatty acid metabolism_Homo sapiens_hsa012121.61991396
20Alzheimers disease_Homo sapiens_hsa050101.61227263
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.59895518
22Amoebiasis_Homo sapiens_hsa051461.56553356
23Notch signaling pathway_Homo sapiens_hsa043301.53695108
24Bladder cancer_Homo sapiens_hsa052191.34922956
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33953476
26Complement and coagulation cascades_Homo sapiens_hsa046101.30066045
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26714963
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25841051
29Nitrogen metabolism_Homo sapiens_hsa009101.24616296
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23978013
31Propanoate metabolism_Homo sapiens_hsa006401.20604036
32Arginine and proline metabolism_Homo sapiens_hsa003301.20420048
33Fatty acid biosynthesis_Homo sapiens_hsa000611.18346810
34Staphylococcus aureus infection_Homo sapiens_hsa051501.17784300
35GABAergic synapse_Homo sapiens_hsa047271.16814883
36Cardiac muscle contraction_Homo sapiens_hsa042601.15545441
37Vibrio cholerae infection_Homo sapiens_hsa051101.15399417
38VEGF signaling pathway_Homo sapiens_hsa043701.14735596
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14544105
40Proteoglycans in cancer_Homo sapiens_hsa052051.09446694
41Pertussis_Homo sapiens_hsa051331.09200776
42Protein digestion and absorption_Homo sapiens_hsa049741.08534278
43Vitamin B6 metabolism_Homo sapiens_hsa007501.08096146
44Linoleic acid metabolism_Homo sapiens_hsa005911.07346439
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06312812
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05771334
47Chronic myeloid leukemia_Homo sapiens_hsa052201.05574293
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05330860
49Serotonergic synapse_Homo sapiens_hsa047261.04427465
50Histidine metabolism_Homo sapiens_hsa003401.01419514
51Glutamatergic synapse_Homo sapiens_hsa047241.00768243
52Osteoclast differentiation_Homo sapiens_hsa043800.99922264
53Phenylalanine metabolism_Homo sapiens_hsa003600.99858685
54Collecting duct acid secretion_Homo sapiens_hsa049660.98930213
55Lysosome_Homo sapiens_hsa041420.98735580
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.96579647
57ECM-receptor interaction_Homo sapiens_hsa045120.95999930
58GnRH signaling pathway_Homo sapiens_hsa049120.93370409
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.93338354
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92770454
61Peroxisome_Homo sapiens_hsa041460.92725312
62Rheumatoid arthritis_Homo sapiens_hsa053230.91466598
63Glutathione metabolism_Homo sapiens_hsa004800.90370599
64Galactose metabolism_Homo sapiens_hsa000520.89226716
65Huntingtons disease_Homo sapiens_hsa050160.88836508
66Renal cell carcinoma_Homo sapiens_hsa052110.87980147
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87545382
68Tight junction_Homo sapiens_hsa045300.87272373
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.86280313
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.85751976
71Arachidonic acid metabolism_Homo sapiens_hsa005900.85040972
72Estrogen signaling pathway_Homo sapiens_hsa049150.84907875
73Acute myeloid leukemia_Homo sapiens_hsa052210.84845389
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83788243
75Melanogenesis_Homo sapiens_hsa049160.82300114
76Glioma_Homo sapiens_hsa052140.82087893
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79881213
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79530825
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78473244
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77732529
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76758561
82Morphine addiction_Homo sapiens_hsa050320.76196468
83Sulfur relay system_Homo sapiens_hsa041220.75378683
84Toxoplasmosis_Homo sapiens_hsa051450.74513685
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73107253
86Fatty acid degradation_Homo sapiens_hsa000710.72935668
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.72565200
88Long-term depression_Homo sapiens_hsa047300.70876190
89Salmonella infection_Homo sapiens_hsa051320.69862987
90Rap1 signaling pathway_Homo sapiens_hsa040150.68538469
91Pentose phosphate pathway_Homo sapiens_hsa000300.67647882
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.66567934
93Salivary secretion_Homo sapiens_hsa049700.66447813
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65890173
95TNF signaling pathway_Homo sapiens_hsa046680.65614109
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.65509328
97Insulin signaling pathway_Homo sapiens_hsa049100.64776893
98* Malaria_Homo sapiens_hsa051440.64426619
99Ovarian steroidogenesis_Homo sapiens_hsa049130.64277610
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63130823
101Pancreatic cancer_Homo sapiens_hsa052120.63025468
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.62774150
103Endocytosis_Homo sapiens_hsa041440.62596947
104Mineral absorption_Homo sapiens_hsa049780.60965776
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60703486
106AMPK signaling pathway_Homo sapiens_hsa041520.60274646
107Ras signaling pathway_Homo sapiens_hsa040140.59986437
108Long-term potentiation_Homo sapiens_hsa047200.59529046
109Adherens junction_Homo sapiens_hsa045200.57203521
110Tuberculosis_Homo sapiens_hsa051520.57115671
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56924870
112Fructose and mannose metabolism_Homo sapiens_hsa000510.56894576
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.56585271
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.54929005
115Leishmaniasis_Homo sapiens_hsa051400.54235627
116Small cell lung cancer_Homo sapiens_hsa052220.54123597
117Nicotine addiction_Homo sapiens_hsa050330.53956895
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53565040
119Pyruvate metabolism_Homo sapiens_hsa006200.53345510
120Gastric acid secretion_Homo sapiens_hsa049710.53225109
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52232871
122Hedgehog signaling pathway_Homo sapiens_hsa043400.51650400
123Phagosome_Homo sapiens_hsa041450.51416577
124Circadian entrainment_Homo sapiens_hsa047130.51213341
125Melanoma_Homo sapiens_hsa052180.50911671
126Endometrial cancer_Homo sapiens_hsa052130.50706909
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50696964
128Cocaine addiction_Homo sapiens_hsa050300.50445129
129Metabolic pathways_Homo sapiens_hsa011000.50048372
130Dilated cardiomyopathy_Homo sapiens_hsa054140.48548860
131Autoimmune thyroid disease_Homo sapiens_hsa053200.47462033
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47415610
133Vitamin digestion and absorption_Homo sapiens_hsa049770.47376265
134Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46995523
135Thyroid hormone synthesis_Homo sapiens_hsa049180.46673943
136Arginine biosynthesis_Homo sapiens_hsa002200.45649648
137mTOR signaling pathway_Homo sapiens_hsa041500.45576728
138PPAR signaling pathway_Homo sapiens_hsa033200.45431356
139Chemical carcinogenesis_Homo sapiens_hsa052040.45221178
140Pancreatic secretion_Homo sapiens_hsa049720.45131037
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45115284
142Insulin resistance_Homo sapiens_hsa049310.44840644
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44824403
144Pathways in cancer_Homo sapiens_hsa052000.44347235
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43558054
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42081176
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40640172
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37822896
149Prion diseases_Homo sapiens_hsa050200.36657999
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35885103
151cAMP signaling pathway_Homo sapiens_hsa040240.35421050
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34817262
153Gap junction_Homo sapiens_hsa045400.34479684
154Cholinergic synapse_Homo sapiens_hsa047250.33583000
155Focal adhesion_Homo sapiens_hsa045100.33069543
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32459088
157Basal cell carcinoma_Homo sapiens_hsa052170.32403826
158Other glycan degradation_Homo sapiens_hsa005110.31830146
159Synaptic vesicle cycle_Homo sapiens_hsa047210.31709592
160Tyrosine metabolism_Homo sapiens_hsa003500.31697629
161Renin secretion_Homo sapiens_hsa049240.31642491
162Bile secretion_Homo sapiens_hsa049760.31626642
163Glycerolipid metabolism_Homo sapiens_hsa005610.31055492
164ErbB signaling pathway_Homo sapiens_hsa040120.30463604

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