CD74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)5.66658258
2* antigen processing and presentation of endogenous antigen (GO:0019883)5.59429797
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.59429797
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.59429797
5NIK/NF-kappaB signaling (GO:0038061)5.42700250
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.41432027
7B cell receptor signaling pathway (GO:0050853)5.41061837
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.34992261
9* B cell mediated immunity (GO:0019724)5.09419666
10detection of bacterium (GO:0016045)4.94168125
11positive regulation of gamma-delta T cell activation (GO:0046645)4.88233797
12cellular response to zinc ion (GO:0071294)4.85327662
13detection of other organism (GO:0098543)4.70573549
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.50817043
15negative regulation of cell killing (GO:0031342)4.50817043
16regulation of interleukin-12 biosynthetic process (GO:0045075)4.48608484
17regulation of interferon-beta biosynthetic process (GO:0045357)4.48211808
18regulation of B cell differentiation (GO:0045577)4.46807160
19positive regulation of interferon-alpha production (GO:0032727)4.43455769
20interferon-gamma-mediated signaling pathway (GO:0060333)4.42557123
21cellular response to exogenous dsRNA (GO:0071360)4.37934701
22myeloid dendritic cell differentiation (GO:0043011)4.34355563
23positive regulation of interleukin-12 production (GO:0032735)4.27126814
24regulation of interferon-alpha production (GO:0032647)4.20179026
25myeloid dendritic cell activation (GO:0001773)4.08679262
26positive regulation of B cell differentiation (GO:0045579)4.06097216
27cytidine metabolic process (GO:0046087)4.04105649
28cytidine catabolic process (GO:0006216)4.04105649
29cytidine deamination (GO:0009972)4.04105649
30regulation of T-helper 1 cell differentiation (GO:0045625)4.00015456
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.97768813
32neutrophil activation involved in immune response (GO:0002283)3.86584401
33positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.84664698
34* regulation of dendritic cell antigen processing and presentation (GO:0002604)3.82481461
35germinal center formation (GO:0002467)3.82137677
36positive regulation of interleukin-2 production (GO:0032743)3.80398765
37response to type I interferon (GO:0034340)3.76483111
38cellular response to type I interferon (GO:0071357)3.75302816
39type I interferon signaling pathway (GO:0060337)3.75302816
40positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.73873669
41* positive thymic T cell selection (GO:0045059)3.73431982
42regulation of alpha-beta T cell proliferation (GO:0046640)3.66909112
43T cell costimulation (GO:0031295)3.66792340
44dendritic cell differentiation (GO:0097028)3.66505983
45lymphocyte costimulation (GO:0031294)3.61412292
46* positive regulation of antigen processing and presentation (GO:0002579)3.60980491
47regulation of interleukin-12 production (GO:0032655)3.60366373
48positive regulation of monocyte chemotaxis (GO:0090026)3.58717995
49neutrophil activation (GO:0042119)3.58030729
50respiratory burst (GO:0045730)3.57715085
51mature B cell differentiation (GO:0002335)3.57375310
52detection of external biotic stimulus (GO:0098581)3.53891530
53JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.53437572
54natural killer cell mediated cytotoxicity (GO:0042267)3.47401376
55natural killer cell mediated immunity (GO:0002228)3.47401376
56defense response to protozoan (GO:0042832)3.46694853
57response to muramyl dipeptide (GO:0032495)3.44657109
58response to interferon-beta (GO:0035456)3.43975356
59regulation of T cell tolerance induction (GO:0002664)3.43800012
60negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.41905940
61regulation of germinal center formation (GO:0002634)3.40691854
62granulocyte activation (GO:0036230)3.39199291
63negative regulation of B cell proliferation (GO:0030889)3.39047207
64positive regulation by symbiont of host defense response (GO:0052509)3.38883725
65modulation by symbiont of host defense response (GO:0052031)3.38883725
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38883725
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38883725
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.38883725
69modulation by symbiont of host immune response (GO:0052553)3.38883725
70response to host immune response (GO:0052572)3.37959354
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37959354
72* regulation of B cell proliferation (GO:0030888)3.37797205
73antigen receptor-mediated signaling pathway (GO:0050851)3.35855164
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.35076696
75response to peptidoglycan (GO:0032494)3.34193157
76cellular response to interferon-beta (GO:0035458)3.33961181
77dendritic cell chemotaxis (GO:0002407)3.33959072
78B cell proliferation (GO:0042100)3.33624427
79regulation of gamma-delta T cell differentiation (GO:0045586)3.32738283
80positive regulation of natural killer cell differentiation (GO:0032825)3.31329057
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.30797617
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30778554
83macrophage activation involved in immune response (GO:0002281)3.30668666
84regulation of gamma-delta T cell activation (GO:0046643)3.29819538
85regulation of RIG-I signaling pathway (GO:0039535)3.26158507
86positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.26037078
87myeloid cell activation involved in immune response (GO:0002275)3.26018208
88cellular response to interferon-gamma (GO:0071346)3.25590645
89* immunoglobulin mediated immune response (GO:0016064)3.25438148
90negative regulation of interleukin-12 production (GO:0032695)3.25198296
91regulation of mast cell degranulation (GO:0043304)3.22543551
92positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21626481
93positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.21303979
94regulation of monocyte chemotaxis (GO:0090025)3.18410699
95leukocyte mediated cytotoxicity (GO:0001909)3.16662050
96regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.15867961
97* regulation of antigen processing and presentation (GO:0002577)3.15653953
98Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15003350
99dendritic cell migration (GO:0036336)3.14876037
100production of molecular mediator of immune response (GO:0002440)3.14350437
101regulation of mast cell activation (GO:0033003)3.10493646
102positive regulation of cytokine biosynthetic process (GO:0042108)3.10395356
103positive regulation of T-helper cell differentiation (GO:0045624)3.10101949
104regulation of MHC class II biosynthetic process (GO:0045346)3.09893435
105response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.09495392
106response to host (GO:0075136)3.09495392
107response to host defenses (GO:0052200)3.09495392
108pyrimidine ribonucleoside catabolic process (GO:0046133)3.09225107
109detection of biotic stimulus (GO:0009595)3.08530235
110positive regulation of interferon-beta production (GO:0032728)3.06049739
111* positive regulation of B cell proliferation (GO:0030890)3.05461280
112regulation of interferon-gamma biosynthetic process (GO:0045072)3.05091283
113positive regulation of alpha-beta T cell proliferation (GO:0046641)3.04432253
114negative regulation of lymphocyte mediated immunity (GO:0002707)3.02305135
115positive regulation of mast cell activation (GO:0033005)3.01561030
116T cell migration (GO:0072678)3.01308230
117negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.99778474
118microglial cell activation (GO:0001774)2.99649209
119negative regulation of leukocyte mediated immunity (GO:0002704)2.99526659
120regulation of mast cell activation involved in immune response (GO:0033006)2.98566783
121response to interferon-gamma (GO:0034341)2.97308534
122T-helper 1 type immune response (GO:0042088)2.95673442
123response to protozoan (GO:0001562)2.93966249
124lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93900791
125* adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.93847175
126mature B cell differentiation involved in immune response (GO:0002313)2.93425081
127regulation of hypersensitivity (GO:0002883)2.91970991
128mast cell activation (GO:0045576)2.91459481
129* T cell selection (GO:0045058)2.91254354
130cellular extravasation (GO:0045123)2.90097877
131negative regulation of innate immune response (GO:0045824)2.89534787
132mucosal-associated lymphoid tissue development (GO:0048537)2.89113695
133Peyers patch development (GO:0048541)2.89113695
134* thymic T cell selection (GO:0045061)2.88315521
135* negative thymic T cell selection (GO:0045060)2.86219165
136* positive regulation of B cell activation (GO:0050871)2.86141059
137regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.84993813
138positive regulation of mast cell degranulation (GO:0043306)2.84397621
139positive regulation of mast cell activation involved in immune response (GO:0033008)2.84397621
140B cell homeostasis (GO:0001782)2.84076337
141regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83572477
142regulation of T cell mediated cytotoxicity (GO:0001914)2.82954390
143* regulation of B cell activation (GO:0050864)2.82408428
144T cell receptor signaling pathway (GO:0050852)2.82261333
145response to interleukin-15 (GO:0070672)2.81235816
146positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77680555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human7.82479793
2* IRF8_21731497_ChIP-ChIP_J774_Mouse6.05746037
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.18966612
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.11687146
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.36080750
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.07584750
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.91936843
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.86558618
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.62817926
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.47047277
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.35855997
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25594410
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.04406679
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98165671
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.95952233
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62460440
17MYC_22102868_ChIP-Seq_BL_Human2.48339601
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42851258
19RUNX_20019798_ChIP-Seq_JUKART_Human2.32500913
20MYB_26560356_Chip-Seq_TH2_Human2.25851181
21VDR_21846776_ChIP-Seq_THP-1_Human2.20702244
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19780130
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19211904
24* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18723250
25MAF_26560356_Chip-Seq_TH1_Human2.17717050
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14682217
27SPI1_23547873_ChIP-Seq_NB4_Human2.08360682
28VDR_24763502_ChIP-Seq_THP-1_Human2.06597685
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06492890
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98872228
31MYB_26560356_Chip-Seq_TH1_Human1.98134553
32* CIITA_25753668_ChIP-Seq_RAJI_Human1.97405265
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92236534
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84945031
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.81543303
36SPI1_23127762_ChIP-Seq_K562_Human1.79036846
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78752083
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77210614
39SCL_19346495_ChIP-Seq_HPC-7_Human1.68486272
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64547890
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62212620
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61845754
43* RUNX1_22412390_ChIP-Seq_EML_Mouse1.59423551
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57046795
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53304008
46TCF7_22412390_ChIP-Seq_EML_Mouse1.49887140
47GATA1_22025678_ChIP-Seq_K562_Human1.49492622
48VDR_24787735_ChIP-Seq_THP-1_Human1.47333316
49UTX_26944678_Chip-Seq_JUKART_Human1.47318804
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46511945
51PU_27001747_Chip-Seq_BMDM_Mouse1.46374300
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41405022
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41397025
54GATA3_27048872_Chip-Seq_THYMUS_Human1.40918869
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.37742232
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36859956
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33308191
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31769913
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30304875
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29975027
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26709405
62* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26232203
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26178276
64* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23802541
65MAF_26560356_Chip-Seq_TH2_Human1.22603318
66GATA3_26560356_Chip-Seq_TH2_Human1.20077478
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17571733
68* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17227074
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16279538
70KDM2B_26808549_Chip-Seq_DND41_Human1.15169331
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14400858
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12973268
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.10877784
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10779489
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09691920
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.07404042
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.02238616
78STAT1_20625510_ChIP-Seq_HELA_Human1.02229056
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02056860
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00586795
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99553977
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99170082
83GATA1_19941826_ChIP-Seq_K562_Human0.99157003
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99151739
85GATA2_21666600_ChIP-Seq_HMVEC_Human0.93925503
86* SMRT_27268052_Chip-Seq_Bcells_Human0.91857291
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91542247
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.91413642
89EGR1_19032775_ChIP-ChIP_M12_Human0.90500383
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89438224
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87622138
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86602199
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86599814
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86386071
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86187965
96E2F1_20622854_ChIP-Seq_HELA_Human0.84118173
97P68_20966046_ChIP-Seq_HELA_Human0.83657304
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83367501
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83192502
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82911408
101EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82012616
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78525956
103P300_27268052_Chip-Seq_Bcells_Human0.74847918
104FOXO3_23340844_ChIP-Seq_DLD1_Human0.72390694
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72075014
106NCOR1_26117541_ChIP-Seq_K562_Human0.68879787
107* LXR_22292898_ChIP-Seq_THP-1_Human0.68666720
108GATA2_19941826_ChIP-Seq_K562_Human0.68237002
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.66653341
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.66653341
111* BCL6_27268052_Chip-Seq_Bcells_Human0.66598379
112CTCF_26484167_Chip-Seq_Bcells_Mouse0.65822639
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65273808
114SPI1_20517297_ChIP-Seq_HL60_Human0.64154603
115BCOR_27268052_Chip-Seq_Bcells_Human0.64002228
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63399127
117* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62963371
118SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.62882655
119CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61461563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation6.23227635
2MP0000685_abnormal_immune_system4.54881661
3MP0005387_immune_system_phenotype4.23872563
4MP0001790_abnormal_immune_system4.23872563
5MP0002254_reproductive_system_inflammat3.78104064
6* MP0001800_abnormal_humoral_immune3.64490215
7MP0005671_abnormal_response_to3.63588054
8MP0004510_myositis3.60004888
9* MP0005000_abnormal_immune_tolerance3.17871643
10* MP0002452_abnormal_antigen_presenting3.10453685
11* MP0002148_abnormal_hypersensitivity_rea3.07987366
12MP0003303_peritoneal_inflammation3.05652382
13MP0009785_altered_susceptibility_to2.74281349
14MP0005310_abnormal_salivary_gland2.71996000
15* MP0002723_abnormal_immune_serum2.71990130
16MP0003436_decreased_susceptibility_to2.60180232
17* MP0005025_abnormal_response_to2.58296676
18* MP0002420_abnormal_adaptive_immunity2.53981483
19* MP0001819_abnormal_immune_cell2.53365482
20MP0002419_abnormal_innate_immunity2.51826605
21MP0001853_heart_inflammation2.43633159
22MP0006082_CNS_inflammation2.15965007
23MP0001348_abnormal_lacrimal_gland2.09559332
24MP0002138_abnormal_hepatobiliary_system2.06969070
25MP0001873_stomach_inflammation2.03447014
26* MP0000716_abnormal_immune_system2.03215791
27MP0002405_respiratory_system_inflammati2.02564746
28* MP0002398_abnormal_bone_marrow2.00033811
29MP0002166_altered_tumor_susceptibility1.86185534
30MP0001845_abnormal_inflammatory_respons1.80739021
31MP0003763_abnormal_thymus_physiology1.78666514
32MP0010155_abnormal_intestine_physiology1.67177341
33MP0000689_abnormal_spleen_morphology1.66345840
34MP0002876_abnormal_thyroid_physiology1.65211627
35MP0004947_skin_inflammation1.63930183
36* MP0002429_abnormal_blood_cell1.59965275
37MP0003806_abnormal_nucleotide_metabolis1.57863620
38MP0002006_tumorigenesis1.57227568
39MP0003300_gastrointestinal_ulcer1.55051418
40MP0009333_abnormal_splenocyte_physiolog1.52080760
41* MP0002722_abnormal_immune_system1.48531123
42MP0005464_abnormal_platelet_physiology1.43127786
43MP0003724_increased_susceptibility_to1.42416916
44MP0001346_abnormal_lacrimal_gland1.39246161
45MP0009764_decreased_sensitivity_to1.31487600
46MP0008469_abnormal_protein_level1.24692490
47MP0001533_abnormal_skeleton_physiology1.19866767
48MP0003183_abnormal_peptide_metabolism1.18322024
49MP0003448_altered_tumor_morphology1.15445263
50MP0002132_abnormal_respiratory_system1.11447407
51MP0010352_gastrointestinal_tract_polyps1.09325194
52MP0008057_abnormal_DNA_replication1.08935361
53MP0005075_abnormal_melanosome_morpholog1.05723756
54MP0005451_abnormal_body_composition1.04810303
55MP0002277_abnormal_respiratory_mucosa1.01851651
56MP0003045_fibrosis1.00934979
57MP0000703_abnormal_thymus_morphology0.99217060
58MP0002933_joint_inflammation0.98126425
59MP0003866_abnormal_defecation0.97964527
60MP0005645_abnormal_hypothalamus_physiol0.94424577
61MP0002139_abnormal_hepatobiliary_system0.92648014
62MP0003453_abnormal_keratinocyte_physiol0.90937242
63MP0005076_abnormal_cell_differentiation0.85153201
64MP0000569_abnormal_digit_pigmentation0.83816061
65MP0002136_abnormal_kidney_physiology0.83788710
66MP0005058_abnormal_lysosome_morphology0.83369714
67MP0003191_abnormal_cellular_cholesterol0.82507474
68MP0000858_altered_metastatic_potential0.80519076
69MP0003075_altered_response_to0.80387277
70MP0003091_abnormal_cell_migration0.80339130
71MP0003828_pulmonary_edema0.80228601
72MP0002877_abnormal_melanocyte_morpholog0.79585926
73MP0008260_abnormal_autophagy0.79380899
74MP0002396_abnormal_hematopoietic_system0.78187256
75MP0000490_abnormal_crypts_of0.77622333
76MP0004782_abnormal_surfactant_physiolog0.76484133
77MP0010234_abnormal_vibrissa_follicle0.75332220
78MP0004808_abnormal_hematopoietic_stem0.72728513
79MP0003566_abnormal_cell_adhesion0.72460132
80MP0005397_hematopoietic_system_phenotyp0.72437302
81MP0001545_abnormal_hematopoietic_system0.72437302
82MP0000343_altered_response_to0.72103469
83MP0009278_abnormal_bone_marrow0.71892440
84MP0001851_eye_inflammation0.71625910
85MP0000015_abnormal_ear_pigmentation0.67776002
86MP0008004_abnormal_stomach_pH0.67505408
87MP0005165_increased_susceptibility_to0.67289615
88MP0002998_abnormal_bone_remodeling0.67069984
89MP0000604_amyloidosis0.66388901
90MP0004883_abnormal_blood_vessel0.64174848
91MP0005166_decreased_susceptibility_to0.61649343
92MP0003172_abnormal_lysosome_physiology0.61176388
93MP0009765_abnormal_xenobiotic_induced0.60320034
94MP0009763_increased_sensitivity_to0.59311102
95MP0003252_abnormal_bile_duct0.59271338
96MP0008874_decreased_physiological_sensi0.59262025
97MP0000249_abnormal_blood_vessel0.58711212
98MP0000465_gastrointestinal_hemorrhage0.57555730
99MP0001663_abnormal_digestive_system0.57269140
100MP0003690_abnormal_glial_cell0.57190637
101MP0000767_abnormal_smooth_muscle0.56988654
102MP0002163_abnormal_gland_morphology0.55368352
103MP0005174_abnormal_tail_pigmentation0.54846226
104MP0002693_abnormal_pancreas_physiology0.54840796
105MP0001986_abnormal_taste_sensitivity0.54043059
106MP0005319_abnormal_enzyme/_coenzyme0.52979495
107MP0005084_abnormal_gallbladder_morpholo0.52317700
108MP0005584_abnormal_enzyme/coenzyme_acti0.52293472
109MP0003795_abnormal_bone_structure0.50625116
110MP0000609_abnormal_liver_physiology0.50061145
111MP0002928_abnormal_bile_duct0.49335132
112MP0005167_abnormal_blood-brain_barrier0.48752774
113MP0002019_abnormal_tumor_incidence0.48427910
114MP0005164_abnormal_response_to0.48307905
115MP0005381_digestive/alimentary_phenotyp0.48085859
116MP0005390_skeleton_phenotype0.47565282
117MP0010307_abnormal_tumor_latency0.47213655
118MP0008875_abnormal_xenobiotic_pharmacok0.46243615
119MP0005023_abnormal_wound_healing0.45592218
120MP0000371_diluted_coat_color0.44992657
121MP0003638_abnormal_response/metabolism_0.44722848
122MP0009840_abnormal_foam_cell0.43266743
123MP0009643_abnormal_urine_homeostasis0.42820303
124MP0002009_preneoplasia0.41756507
125MP0002168_other_aberrant_phenotype0.41175039
126MP0000470_abnormal_stomach_morphology0.40981963

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.81758000
2Recurrent abscess formation (HP:0002722)5.78275169
3Gastrointestinal stroma tumor (HP:0100723)5.57102106
4Recurrent bacterial skin infections (HP:0005406)5.55862359
5Colitis (HP:0002583)5.43022950
6Eczematoid dermatitis (HP:0000976)5.41999917
7Chronic mucocutaneous candidiasis (HP:0002728)5.33932779
8Recurrent cutaneous fungal infections (HP:0011370)5.33932779
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.86495357
10Recurrent bronchitis (HP:0002837)4.75703890
11Recurrent fungal infections (HP:0002841)4.67314232
12Cellulitis (HP:0100658)4.62923418
13Recurrent skin infections (HP:0001581)4.60272485
14Recurrent viral infections (HP:0004429)4.49085975
15Inflammation of the large intestine (HP:0002037)4.44752623
16Vasculitis (HP:0002633)4.37578822
17Chronic otitis media (HP:0000389)4.29680099
18Gastrointestinal inflammation (HP:0004386)4.20829516
19Recurrent sinusitis (HP:0011108)4.10882025
20Interstitial pulmonary disease (HP:0006530)4.07610974
21Mediastinal lymphadenopathy (HP:0100721)4.03763661
22Meningitis (HP:0001287)4.02950928
23Recurrent gram-negative bacterial infections (HP:0005420)3.99506402
24Elevated erythrocyte sedimentation rate (HP:0003565)3.97432537
25Panhypogammaglobulinemia (HP:0003139)3.96476762
26Emphysema (HP:0002097)3.94667141
27Autoimmune thrombocytopenia (HP:0001973)3.78863853
28Recurrent lower respiratory tract infections (HP:0002783)3.67056563
29Myositis (HP:0100614)3.60060579
30Chronic sinusitis (HP:0011109)3.49348625
31Lymphopenia (HP:0001888)3.47417991
32Recurrent pneumonia (HP:0006532)3.46795242
33Abnormality of cells of the lymphoid lineage (HP:0012140)3.46235235
34IgM deficiency (HP:0002850)3.42051954
35Abnormality of the prostate (HP:0008775)3.38552466
36Abnormality of B cell number (HP:0010975)3.36708967
37IgA deficiency (HP:0002720)3.31519604
38Osteomyelitis (HP:0002754)3.20904850
39Optic neuritis (HP:0100653)3.18892084
40Retrobulbar optic neuritis (HP:0100654)3.18892084
41Gingivitis (HP:0000230)3.18131195
42Keratoconjunctivitis (HP:0001096)3.17186768
43B lymphocytopenia (HP:0010976)3.13627358
44Pulmonary infiltrates (HP:0002113)3.12635197
45Orchitis (HP:0100796)3.10995588
46Papilloma (HP:0012740)3.10983614
47Verrucae (HP:0200043)3.10983614
48Systemic lupus erythematosus (HP:0002725)3.10557992
49Abnormality of macrophages (HP:0004311)3.08461245
50Chronic obstructive pulmonary disease (HP:0006510)3.07859307
51Obstructive lung disease (HP:0006536)3.07859307
52Pustule (HP:0200039)3.06498382
53Restrictive lung disease (HP:0002091)3.04119085
54Increased IgE level (HP:0003212)2.96738136
55Nasal polyposis (HP:0100582)2.95244860
56Abnormality of liposaccharide metabolism (HP:0010968)2.92042605
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.92042605
58Abnormality of glycolipid metabolism (HP:0010969)2.92042605
59Increased IgM level (HP:0003496)2.86666803
60Periodontitis (HP:0000704)2.85970324
61Hematochezia (HP:0002573)2.84452933
62Abnormality of T cell physiology (HP:0011840)2.83392615
63Increased cerebral lipofuscin (HP:0011813)2.78493937
64Viral hepatitis (HP:0006562)2.76992772
65Thrombocytosis (HP:0001894)2.73613854
66Bronchitis (HP:0012387)2.72283114
67Hypergammaglobulinemia (HP:0010702)2.71618398
68Abnormality of the pleura (HP:0002103)2.68064824
69Encephalitis (HP:0002383)2.67375440
70T lymphocytopenia (HP:0005403)2.61391672
71Arterial thrombosis (HP:0004420)2.59502749
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.58852058
73Abnormality of the nasal mucosa (HP:0000433)2.57641535
74Sepsis (HP:0100806)2.56720378
75IgG deficiency (HP:0004315)2.54524700
76Hypertensive crisis (HP:0100735)2.54092467
77Autoimmune hemolytic anemia (HP:0001890)2.53255943
78Severe combined immunodeficiency (HP:0004430)2.53248419
79Myocardial infarction (HP:0001658)2.50900920
80Abnormality of T cells (HP:0002843)2.49814862
81Pulmonary fibrosis (HP:0002206)2.48372121
82Gastrointestinal infarctions (HP:0005244)2.43416343
83Vacuolated lymphocytes (HP:0001922)2.41612917
84Skin ulcer (HP:0200042)2.39539695
85Chronic diarrhea (HP:0002028)2.38958362
86Urticaria (HP:0001025)2.38019004
87Epistaxis (HP:0000421)2.33131922
88Keratoconjunctivitis sicca (HP:0001097)2.32092582
89Leukopenia (HP:0001882)2.30365058
90Abnormality of T cell number (HP:0011839)2.29541203
91Petechiae (HP:0000967)2.28307042
92Osteolytic defects of the phalanges of the hand (HP:0009771)2.27077340
93Osteolytic defects of the hand bones (HP:0009699)2.27077340
94Mitral stenosis (HP:0001718)2.26454956
95Arthralgia (HP:0002829)2.25143081
96Thyroiditis (HP:0100646)2.24194519
97Spontaneous hematomas (HP:0007420)2.21848473
98Eosinophilia (HP:0001880)2.21403623
99Abnormality of small intestinal villus morphology (HP:0011472)2.21340842
100Villous atrophy (HP:0011473)2.21340842
101Combined immunodeficiency (HP:0005387)2.20983725
102Pulmonary embolism (HP:0002204)2.18331740
103Xerostomia (HP:0000217)2.17407278
104Gangrene (HP:0100758)2.17297164
105Stomatitis (HP:0010280)2.17101895
106Prostate neoplasm (HP:0100787)2.16995243
107Leukocytosis (HP:0001974)2.16796387
108Dysostosis multiplex (HP:0000943)2.15465079
109Hepatosplenomegaly (HP:0001433)2.14618945
110Purpura (HP:0000979)2.14091103
111Chest pain (HP:0100749)2.09526176
112Abnormality of the peritoneum (HP:0002585)2.07418640
113Hemoptysis (HP:0002105)2.04419672
114Acrocyanosis (HP:0001063)2.04148170
115Thick nail (HP:0001805)2.03690365
116Gingival bleeding (HP:0000225)2.01629865
117Abnormality of the fingertips (HP:0001211)2.01402643
118Skin rash (HP:0000988)2.01086113
119Lymphoma (HP:0002665)1.98976824
120Glomerulonephritis (HP:0000099)1.97770533
121Basal ganglia calcification (HP:0002135)1.96151445
122Granulocytopenia (HP:0001913)1.95482338
123Fatigue (HP:0012378)1.93781397
124Hepatitis (HP:0012115)1.91822773
125Recurrent otitis media (HP:0000403)1.91238649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.36197375
2MAP3K145.03885853
3BLK4.11743400
4TYK23.26366617
5RIPK43.04390845
6MAP3K132.93262148
7TESK22.89719418
8TBK12.80800964
9IRAK42.72410983
10IKBKB2.52765740
11ERN12.45276120
12CSF1R2.43766146
13JAK32.41711829
14SYK2.34153542
15JAK12.28376999
16KIT2.10595896
17IRAK32.09349200
18BTK2.07444633
19IKBKE2.04939666
20MST41.96125427
21CHUK1.90186633
22KDR1.87956707
23EPHB11.70240611
24LRRK21.69182519
25STK101.68338921
26PRPF4B1.63751678
27CSK1.59034201
28ZAP701.48823175
29FGFR41.47809564
30TNK21.46583980
31GRK61.45794117
32EPHA31.45349084
33LYN1.43968120
34MAP3K111.38841812
35HCK1.29398287
36BCKDK1.24093764
37FGFR31.21434882
38ITK1.19061658
39TLK11.16898403
40TGFBR21.13945107
41TEC1.09087654
42MATK1.08929414
43SIK31.08438708
44MAP3K101.06270483
45PRKCQ1.06262831
46NME21.03134006
47LCK1.01814563
48BMPR21.01558504
49SIK21.00263018
50JAK20.99779428
51NEK90.96561152
52MARK30.91448200
53PIM10.85398901
54RPS6KA40.83723546
55FGR0.82785503
56MAPKAPK30.82603815
57CDC42BPA0.82184600
58TXK0.81958999
59GRK10.81844688
60PIK3CG0.79682213
61CLK10.76147083
62FES0.76036313
63MAPK120.75920809
64MAPK110.74656975
65SMG10.71627115
66CDK190.70978856
67VRK20.68544080
68TAOK30.66611830
69MAP3K10.64140021
70PRKCD0.63521417
71PRKCH0.62998477
72MAPK70.62961337
73TAOK20.59280857
74PTK60.58860103
75ABL10.58744994
76NLK0.57319050
77CDK120.57011800
78IRAK10.54032162
79MAPKAPK20.53899881
80DAPK10.52737113
81CCNB10.52072130
82DYRK1B0.50455674
83CDK40.49232082
84MAP2K30.49128809
85EGFR0.45477506
86SIK10.41016644
87PDPK10.40132924
88PIM20.40117555
89VRK10.39984512
90PKN10.38552243
91ALK0.37531031
92MAPK40.37129379
93ARAF0.36889902
94FYN0.34371693
95INSR0.34178007
96ADRBK20.33929733
97RPS6KL10.33656989
98RPS6KC10.33656989
99TTN0.30650717
100TRPM70.30509318
101TAOK10.29938907
102EIF2AK20.29868725
103ZAK0.29822105
104HIPK20.29709141
105EIF2AK30.29401092
106BMX0.28809477
107RPS6KA60.28726077
108STK240.28176628
109PDK10.28039874
110MAP3K50.26993943
111STK40.24941370
112MAP3K90.24730475
113TRIB30.23855974
114SCYL20.23419537
115DAPK30.23328820
116MAP2K20.22933372
117MAP3K80.21766560
118MOS0.19390020
119MAPK150.19238240
120CDK90.19159217
121MAPK30.16341684
122SRC0.15886086
123IGF1R0.15588355
124PRKCI0.15137279
125PRKAA20.14734437
126YES10.14310064
127PRKD10.13483565
128DYRK30.13120711
129FLT30.12787176
130MAP3K70.12163494
131MAP3K30.12101978
132GRK70.11950698
133RPS6KA50.11668818
134RPS6KA10.10891584

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.37874675
2B cell receptor signaling pathway_Homo sapiens_hsa046623.77336430
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.48877007
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.30568422
5Leishmaniasis_Homo sapiens_hsa051403.06395429
6Allograft rejection_Homo sapiens_hsa053302.62670119
7Osteoclast differentiation_Homo sapiens_hsa043802.59712919
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47819373
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36917403
10Graft-versus-host disease_Homo sapiens_hsa053322.35313945
11* Antigen processing and presentation_Homo sapiens_hsa046122.31251386
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99044247
13Measles_Homo sapiens_hsa051621.96320261
14Hematopoietic cell lineage_Homo sapiens_hsa046401.94028453
15Staphylococcus aureus infection_Homo sapiens_hsa051501.93615851
16Toxoplasmosis_Homo sapiens_hsa051451.85904480
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85579254
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82479045
19* Tuberculosis_Homo sapiens_hsa051521.82297569
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80299063
21Pertussis_Homo sapiens_hsa051331.77079377
22Chemokine signaling pathway_Homo sapiens_hsa040621.76194537
23Influenza A_Homo sapiens_hsa051641.70721923
24Legionellosis_Homo sapiens_hsa051341.69539536
25Systemic lupus erythematosus_Homo sapiens_hsa053221.68758315
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65614357
27Autoimmune thyroid disease_Homo sapiens_hsa053201.61776214
28Viral myocarditis_Homo sapiens_hsa054161.61724600
29Malaria_Homo sapiens_hsa051441.55311526
30TNF signaling pathway_Homo sapiens_hsa046681.54686834
31African trypanosomiasis_Homo sapiens_hsa051431.53101495
32* Herpes simplex infection_Homo sapiens_hsa051681.51866880
33Apoptosis_Homo sapiens_hsa042101.50978336
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49018096
35Type I diabetes mellitus_Homo sapiens_hsa049401.43659419
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.41851623
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41523927
38T cell receptor signaling pathway_Homo sapiens_hsa046601.36451401
39Shigellosis_Homo sapiens_hsa051311.34872987
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27620551
41Salmonella infection_Homo sapiens_hsa051321.26004485
42Asthma_Homo sapiens_hsa053101.18521569
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.18099644
44Rheumatoid arthritis_Homo sapiens_hsa053231.16752309
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11311516
46Hepatitis B_Homo sapiens_hsa051611.08729126
47Lysosome_Homo sapiens_hsa041420.99405377
48Epstein-Barr virus infection_Homo sapiens_hsa051690.99109791
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93748999
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93352969
51Acute myeloid leukemia_Homo sapiens_hsa052210.91022075
52Hepatitis C_Homo sapiens_hsa051600.87379064
53Pancreatic cancer_Homo sapiens_hsa052120.83491302
54Phagosome_Homo sapiens_hsa041450.78978278
55Chronic myeloid leukemia_Homo sapiens_hsa052200.76250656
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75598221
57Prolactin signaling pathway_Homo sapiens_hsa049170.74831370
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73504775
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.72366580
60Other glycan degradation_Homo sapiens_hsa005110.69848350
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66523685
62Small cell lung cancer_Homo sapiens_hsa052220.66330426
63Platelet activation_Homo sapiens_hsa046110.65681578
64HTLV-I infection_Homo sapiens_hsa051660.61992059
65Viral carcinogenesis_Homo sapiens_hsa052030.60738812
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.58361200
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58076327
68VEGF signaling pathway_Homo sapiens_hsa043700.51109358
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50567892
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.47648039
71Amoebiasis_Homo sapiens_hsa051460.46961475
72Notch signaling pathway_Homo sapiens_hsa043300.42522097
73Base excision repair_Homo sapiens_hsa034100.39465629
74MAPK signaling pathway_Homo sapiens_hsa040100.39253895
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38481994
76Complement and coagulation cascades_Homo sapiens_hsa046100.37752131
77Non-small cell lung cancer_Homo sapiens_hsa052230.36839143
78p53 signaling pathway_Homo sapiens_hsa041150.36334493
79Phenylalanine metabolism_Homo sapiens_hsa003600.36051276
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36007290
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35210668
82Insulin resistance_Homo sapiens_hsa049310.33211458
83Endocytosis_Homo sapiens_hsa041440.32258016
84Proteoglycans in cancer_Homo sapiens_hsa052050.31167531
85Prion diseases_Homo sapiens_hsa050200.29773726
86Arachidonic acid metabolism_Homo sapiens_hsa005900.27751098
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.27481678
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25571739
89MicroRNAs in cancer_Homo sapiens_hsa052060.23590668
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23517235
91Dorso-ventral axis formation_Homo sapiens_hsa043200.23063622
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22274838
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20310972
94FoxO signaling pathway_Homo sapiens_hsa040680.19067770
95Pathways in cancer_Homo sapiens_hsa052000.18291299
96Adherens junction_Homo sapiens_hsa045200.17875970
97Inositol phosphate metabolism_Homo sapiens_hsa005620.16337970
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.15602098
99HIF-1 signaling pathway_Homo sapiens_hsa040660.15309938
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11451242
101ABC transporters_Homo sapiens_hsa020100.11258123
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10451467
103Caffeine metabolism_Homo sapiens_hsa002320.09546933
104Linoleic acid metabolism_Homo sapiens_hsa005910.09277644
105Ether lipid metabolism_Homo sapiens_hsa005650.09255512
106Prostate cancer_Homo sapiens_hsa052150.09229208
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08172512
108Pentose phosphate pathway_Homo sapiens_hsa000300.07896188
109Focal adhesion_Homo sapiens_hsa045100.07228618
110Proteasome_Homo sapiens_hsa030500.06887661
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.06378555
112Alcoholism_Homo sapiens_hsa050340.03858196
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02581400
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.01627676
115Collecting duct acid secretion_Homo sapiens_hsa04966-0.0653292
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0626601
117Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0525571
118Regulation of autophagy_Homo sapiens_hsa04140-0.0416349
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0369666
120Peroxisome_Homo sapiens_hsa04146-0.0335888
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0039148
122Renin-angiotensin system_Homo sapiens_hsa04614-0.0024404

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