CD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.30295557
2negative thymic T cell selection (GO:0045060)8.16903765
3positive regulation of gamma-delta T cell activation (GO:0046645)7.79630241
4positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.48365935
5positive thymic T cell selection (GO:0045059)7.14485110
6regulation of isotype switching to IgG isotypes (GO:0048302)6.91504141
7regulation of gamma-delta T cell differentiation (GO:0045586)6.83002221
8response to interleukin-15 (GO:0070672)6.72542477
9thymic T cell selection (GO:0045061)6.70804962
10positive T cell selection (GO:0043368)6.70709658
11T cell selection (GO:0045058)6.33856410
12regulation of gamma-delta T cell activation (GO:0046643)6.16012167
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.13273106
14negative regulation of cell killing (GO:0031342)6.13273106
15regulation of interleukin-2 biosynthetic process (GO:0045076)6.11717322
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.07083933
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.05055736
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.05055736
19cellular response to interleukin-15 (GO:0071350)5.85672164
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.69064428
21interferon-gamma production (GO:0032609)5.39326738
22tolerance induction (GO:0002507)5.30119425
23regulation of T cell tolerance induction (GO:0002664)5.24145925
24regulation of interleukin-12 biosynthetic process (GO:0045075)5.19980860
25T cell receptor signaling pathway (GO:0050852)5.12730382
26leukocyte aggregation (GO:0070486)5.06957584
27antigen processing and presentation of endogenous antigen (GO:0019883)4.99694186
28regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.97049680
29positive regulation of interleukin-2 production (GO:0032743)4.88709814
30activated T cell proliferation (GO:0050798)4.87158834
31T cell migration (GO:0072678)4.85004576
32regulation of regulatory T cell differentiation (GO:0045589)4.70672323
33regulation of alpha-beta T cell proliferation (GO:0046640)4.67848981
34positive regulation of granulocyte differentiation (GO:0030854)4.58381207
35positive regulation of isotype switching (GO:0045830)4.57188337
36* T cell costimulation (GO:0031295)4.53744534
37* lymphocyte costimulation (GO:0031294)4.46750735
38positive regulation of humoral immune response (GO:0002922)4.45509564
39positive regulation of tolerance induction (GO:0002645)4.31435104
40regulation of isotype switching (GO:0045191)4.22458296
41positive regulation of alpha-beta T cell proliferation (GO:0046641)4.19191097
42CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.12656736
43antigen receptor-mediated signaling pathway (GO:0050851)4.10138248
44positive regulation of natural killer cell mediated immunity (GO:0002717)4.08666631
45positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.08666631
46negative regulation of T cell mediated immunity (GO:0002710)4.05273888
47regulation of interleukin-2 production (GO:0032663)3.97603454
48tyrosine phosphorylation of STAT protein (GO:0007260)3.96561744
49positive regulation of immunoglobulin mediated immune response (GO:0002891)3.94926514
50positive regulation of B cell mediated immunity (GO:0002714)3.94926514
51regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.91900967
52regulation of natural killer cell mediated immunity (GO:0002715)3.91900967
53positive regulation of DNA recombination (GO:0045911)3.88165139
54regulation of T cell receptor signaling pathway (GO:0050856)3.86879126
55NIK/NF-kappaB signaling (GO:0038061)3.77981244
56positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.76581775
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.75696295
58regulation of immunoglobulin mediated immune response (GO:0002889)3.74401673
59regulation of tolerance induction (GO:0002643)3.72252404
60regulation of B cell receptor signaling pathway (GO:0050855)3.64656342
61JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.63313941
62regulation of B cell mediated immunity (GO:0002712)3.60567787
63B cell receptor signaling pathway (GO:0050853)3.60449614
64regulation of immunoglobulin production (GO:0002637)3.58171105
65positive regulation of natural killer cell differentiation (GO:0032825)3.57236272
66regulation of B cell differentiation (GO:0045577)3.55620227
67negative regulation of leukocyte mediated immunity (GO:0002704)3.50357007
68positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.46842956
69positive regulation of immunoglobulin production (GO:0002639)3.45524318
70T cell homeostasis (GO:0043029)3.45278796
71regulation of T cell mediated cytotoxicity (GO:0001914)3.42761380
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.42498352
73positive regulation of T cell differentiation in thymus (GO:0033089)3.42097067
74T cell differentiation (GO:0030217)3.34610439
75alpha-beta T cell differentiation (GO:0046632)3.34376903
76positive regulation of B cell differentiation (GO:0045579)3.32170469
77Peyers patch development (GO:0048541)3.30992367
78mucosal-associated lymphoid tissue development (GO:0048537)3.30992367
79alpha-beta T cell activation (GO:0046631)3.30839800
80negative regulation of lymphocyte mediated immunity (GO:0002707)3.29944829
81positive regulation of lymphocyte mediated immunity (GO:0002708)3.28453242
82regulation of response to interferon-gamma (GO:0060330)3.25252888
83regulation of granulocyte differentiation (GO:0030852)3.25096865
84regulation of leukocyte mediated cytotoxicity (GO:0001910)3.24881618
85positive regulation of T cell mediated cytotoxicity (GO:0001916)3.24830416
86regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.24729048
87antigen processing and presentation via MHC class Ib (GO:0002475)3.24648693
88regulation of immunoglobulin secretion (GO:0051023)3.22267210
89positive regulation of interleukin-4 production (GO:0032753)3.21761707
90detection of bacterium (GO:0016045)3.18939298
91regulation of defense response to virus by virus (GO:0050690)3.18141192
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.16563864
93negative regulation of T-helper cell differentiation (GO:0045623)3.16563864
94T cell proliferation (GO:0042098)3.16371460
95CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.15886484
96T-helper cell differentiation (GO:0042093)3.15886484
97positive regulation of cell killing (GO:0031343)3.15421672
98natural killer cell differentiation (GO:0001779)3.13507413
99negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.11286007
100lymph node development (GO:0048535)3.09941266
101cellular response to interleukin-4 (GO:0071353)3.09909215
102mast cell activation (GO:0045576)3.09246018
103type I interferon signaling pathway (GO:0060337)3.09134289
104cellular response to type I interferon (GO:0071357)3.09134289
105T cell activation (GO:0042110)3.09119619
106regulation of lymphocyte mediated immunity (GO:0002706)3.08626632
107response to type I interferon (GO:0034340)3.07818040
108myeloid dendritic cell activation (GO:0001773)3.07273707
109T cell lineage commitment (GO:0002360)3.07031365
110regulation of alpha-beta T cell activation (GO:0046634)3.06911613
111detection of other organism (GO:0098543)3.06884801
112cellular extravasation (GO:0045123)3.06552013
113lymphocyte migration (GO:0072676)3.05510240
114regulation of interleukin-4 production (GO:0032673)3.05482724
115positive regulation of alpha-beta T cell activation (GO:0046635)3.04296167
116CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.03889915
117myeloid dendritic cell differentiation (GO:0043011)3.03602339
118negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.02362357
119negative regulation of erythrocyte differentiation (GO:0045647)3.00551672
120regulation of chronic inflammatory response (GO:0002676)2.99904722
121regulation of cell killing (GO:0031341)2.99079407
122negative regulation of interleukin-12 production (GO:0032695)2.97670286
123positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96548860
124* positive regulation of T cell activation (GO:0050870)2.95017055
125regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.94691093
126positive regulation of T cell cytokine production (GO:0002726)2.94472079
127regulation of type I interferon-mediated signaling pathway (GO:0060338)2.94400324
128leukocyte cell-cell adhesion (GO:0007159)2.93567608
129positive regulation of T cell differentiation (GO:0045582)2.92451130
130natural killer cell activation (GO:0030101)2.92313346
131lymphocyte homeostasis (GO:0002260)2.88746358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.14832981
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.05092450
3E2F7_22180533_ChIP-Seq_HELA_Human4.68536116
4MYC_22102868_ChIP-Seq_BL_Human4.11747303
5* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.54985959
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.45478364
7RUNX_20019798_ChIP-Seq_JUKART_Human3.37989352
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.28832768
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.18760263
10MYB_26560356_Chip-Seq_TH2_Human3.13193610
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04712492
12MAF_26560356_Chip-Seq_TH1_Human2.98004916
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91755186
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.78861426
15MYB_26560356_Chip-Seq_TH1_Human2.72110751
16UTX_26944678_Chip-Seq_JUKART_Human2.66938873
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.61673912
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.61516571
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.58078391
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53568845
21VDR_21846776_ChIP-Seq_THP-1_Human2.41246184
22* MAF_26560356_Chip-Seq_TH2_Human2.24427980
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.23212510
24* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20507241
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11515171
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03365914
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01905812
28TCF7_22412390_ChIP-Seq_EML_Mouse1.99903971
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95884852
30GATA3_27048872_Chip-Seq_THYMUS_Human1.94119570
31KDM2B_26808549_Chip-Seq_DND41_Human1.83740171
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80182863
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74127256
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.71182196
35VDR_24763502_ChIP-Seq_THP-1_Human1.65625656
36CIITA_25753668_ChIP-Seq_RAJI_Human1.65517276
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62485368
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58230059
39SPI1_23547873_ChIP-Seq_NB4_Human1.57999630
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56012938
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50961642
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43874033
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43845738
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43496687
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41831930
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37787461
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36863035
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.36837277
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36159185
50VDR_23849224_ChIP-Seq_CD4+_Human1.34913056
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.33999163
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.32651572
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32188267
54FOXP3_21729870_ChIP-Seq_TREG_Human1.31925784
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.28765185
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27174472
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.24319052
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23354940
59SCL_19346495_ChIP-Seq_HPC-7_Human1.21804305
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20859701
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20599775
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19995804
63SPI1_23127762_ChIP-Seq_K562_Human1.18224033
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.16207563
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15511655
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12072421
67GATA3_26560356_Chip-Seq_TH2_Human1.08103846
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08011301
69XRN2_22483619_ChIP-Seq_HELA_Human1.07699720
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07290362
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07134860
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.03360677
73PU_27001747_Chip-Seq_BMDM_Mouse1.03207674
74KDM5A_27292631_Chip-Seq_BREAST_Human1.01614070
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01188707
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99319350
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99214859
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97599443
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96613666
80VDR_24787735_ChIP-Seq_THP-1_Human0.95756276
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94297889
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93656202
83GATA1_19941826_ChIP-Seq_K562_Human0.92601450
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89964643
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89555672
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88934588
87ELK1_19687146_ChIP-ChIP_HELA_Human0.88421252
88CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88109964
89* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87373111
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87344896
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86881045
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86827231
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86248715
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85988850
95BCOR_27268052_Chip-Seq_Bcells_Human0.85936384
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85275131
97NCOR1_26117541_ChIP-Seq_K562_Human0.85172621
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84677942
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84446332
100BCL6_27268052_Chip-Seq_Bcells_Human0.83236469
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81457220
102EST1_17652178_ChIP-ChIP_JURKAT_Human0.79194616
103* SA1_27219007_Chip-Seq_ERYTHROID_Human0.79028814
104GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78081486
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77348854
106E2F1_21310950_ChIP-Seq_MCF-7_Human0.76929511
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76784367
108MYC_19030024_ChIP-ChIP_MESCs_Mouse0.75780567
109HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75121870
110CTCF_21964334_ChIP-Seq_BJAB-B_Human0.74487741
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74451673
112* ELF1_20517297_ChIP-Seq_JURKAT_Human0.73650357
113GATA3_26560356_Chip-Seq_TH1_Human0.73478670
114GABP_17652178_ChIP-ChIP_JURKAT_Human0.73423519
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71130209
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.70933714
117SMAD_19615063_ChIP-ChIP_OVARY_Human0.70821439
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70577116
119ETS1_20019798_ChIP-Seq_JURKAT_Human0.70003631
120LXR_22292898_ChIP-Seq_THP-1_Human0.69500279
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.69014068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.19414306
2MP0005671_abnormal_response_to3.97821555
3MP0000685_abnormal_immune_system3.76268737
4MP0001800_abnormal_humoral_immune3.13211336
5MP0005387_immune_system_phenotype3.08519106
6MP0001790_abnormal_immune_system3.08519106
7MP0009333_abnormal_splenocyte_physiolog3.08297566
8MP0002166_altered_tumor_susceptibility3.05063175
9MP0003436_decreased_susceptibility_to2.99357075
10MP0003866_abnormal_defecation2.97716398
11MP0002396_abnormal_hematopoietic_system2.88870519
12MP0003300_gastrointestinal_ulcer2.85136255
13MP0005000_abnormal_immune_tolerance2.83627902
14MP0002398_abnormal_bone_marrow2.81189350
15MP0000703_abnormal_thymus_morphology2.80891537
16MP0001835_abnormal_antigen_presentation2.76836275
17MP0002405_respiratory_system_inflammati2.74845413
18MP0002723_abnormal_immune_serum2.69670879
19MP0001873_stomach_inflammation2.66672151
20MP0002420_abnormal_adaptive_immunity2.65498657
21MP0001819_abnormal_immune_cell2.60211196
22MP0002006_tumorigenesis2.51969197
23MP0002452_abnormal_antigen_presenting2.42178854
24MP0002933_joint_inflammation2.41745129
25MP0000716_abnormal_immune_system2.36347973
26MP0010155_abnormal_intestine_physiology2.35596926
27MP0002722_abnormal_immune_system2.29985163
28MP0009785_altered_susceptibility_to2.28804426
29MP0000689_abnormal_spleen_morphology2.25165181
30MP0003303_peritoneal_inflammation2.21942811
31MP0006082_CNS_inflammation2.19673211
32MP0005025_abnormal_response_to2.19552386
33MP0003724_increased_susceptibility_to1.98512689
34MP0002429_abnormal_blood_cell1.94458133
35MP0004947_skin_inflammation1.88976169
36MP0004510_myositis1.79005253
37MP0002148_abnormal_hypersensitivity_rea1.67944880
38MP0004808_abnormal_hematopoietic_stem1.65993602
39MP0001853_heart_inflammation1.63265423
40MP0001845_abnormal_inflammatory_respons1.59248224
41MP0002419_abnormal_innate_immunity1.48355313
42MP0008057_abnormal_DNA_replication1.40767643
43MP0004381_abnormal_hair_follicle1.39776255
44MP0005464_abnormal_platelet_physiology1.35136863
45MP0002277_abnormal_respiratory_mucosa1.32602695
46MP0010352_gastrointestinal_tract_polyps1.31451491
47MP0000465_gastrointestinal_hemorrhage1.30981061
48MP0005310_abnormal_salivary_gland1.26142437
49MP0008961_abnormal_basal_metabolism1.24562432
50MP0008260_abnormal_autophagy1.19937043
51MP0000490_abnormal_crypts_of1.17780497
52MP0000858_altered_metastatic_potential1.16327092
53MP0001533_abnormal_skeleton_physiology1.14652615
54MP0003172_abnormal_lysosome_physiology1.05230554
55MP0002019_abnormal_tumor_incidence1.03692382
56MP0001851_eye_inflammation1.02406534
57MP0002254_reproductive_system_inflammat1.02176482
58MP0003448_altered_tumor_morphology1.01530713
59MP0005076_abnormal_cell_differentiation0.99726534
60MP0003077_abnormal_cell_cycle0.98777705
61MP0002138_abnormal_hepatobiliary_system0.98706961
62MP0002163_abnormal_gland_morphology0.96347011
63MP0008469_abnormal_protein_level0.94337771
64MP0003693_abnormal_embryo_hatching0.90319656
65MP0001545_abnormal_hematopoietic_system0.88232153
66MP0005397_hematopoietic_system_phenotyp0.88232153
67MP0003191_abnormal_cellular_cholesterol0.88182080
68MP0004957_abnormal_blastocyst_morpholog0.87637513
69MP0002822_catalepsy0.83050010
70MP0005023_abnormal_wound_healing0.80788745
71MP0010094_abnormal_chromosome_stability0.80722385
72MP0004130_abnormal_muscle_cell0.80405543
73MP0003828_pulmonary_edema0.78959252
74MP0005075_abnormal_melanosome_morpholog0.78830693
75MP0002998_abnormal_bone_remodeling0.78435131
76MP0002009_preneoplasia0.76872156
77MP0002693_abnormal_pancreas_physiology0.72683879
78MP0002132_abnormal_respiratory_system0.70904983
79MP0001348_abnormal_lacrimal_gland0.69454498
80MP0000604_amyloidosis0.67908483
81MP0003111_abnormal_nucleus_morphology0.66297716
82MP0004883_abnormal_blood_vessel0.66181381
83MP0009765_abnormal_xenobiotic_induced0.65043341
84MP0001663_abnormal_digestive_system0.64172092
85MP0000350_abnormal_cell_proliferation0.63517387
86MP0004185_abnormal_adipocyte_glucose0.63044742
87MP0001881_abnormal_mammary_gland0.62788439
88MP0000609_abnormal_liver_physiology0.62695489
89MP0000477_abnormal_intestine_morphology0.61724053
90MP0003795_abnormal_bone_structure0.58661370
91MP0001919_abnormal_reproductive_system0.58570093
92MP0000313_abnormal_cell_death0.58379599
93MP0005381_digestive/alimentary_phenotyp0.57435425
94MP0009763_increased_sensitivity_to0.55993910
95MP0008007_abnormal_cellular_replicative0.55777218
96MP0001730_embryonic_growth_arrest0.54670522
97MP0005166_decreased_susceptibility_to0.54383901
98MP0008995_early_reproductive_senescence0.53171368
99MP0000015_abnormal_ear_pigmentation0.51026691
100MP0003453_abnormal_keratinocyte_physiol0.50737569
101MP0009764_decreased_sensitivity_to0.50613527
102MP0001216_abnormal_epidermal_layer0.50291862
103MP0003045_fibrosis0.50130761
104MP0000249_abnormal_blood_vessel0.49361388
105MP0009115_abnormal_fat_cell0.49149322
106MP0003091_abnormal_cell_migration0.48587933
107MP0001243_abnormal_dermal_layer0.48549406
108MP0001986_abnormal_taste_sensitivity0.47791815
109MP0009278_abnormal_bone_marrow0.46717899
110MP0009840_abnormal_foam_cell0.45181361
111MP0000627_abnormal_mammary_gland0.43355720
112MP0005379_endocrine/exocrine_gland_phen0.42652721
113MP0008058_abnormal_DNA_repair0.41927275
114MP0002088_abnormal_embryonic_growth/wei0.41221268
115MP0008004_abnormal_stomach_pH0.40348383
116MP0001191_abnormal_skin_condition0.40029882
117MP0002086_abnormal_extraembryonic_tissu0.39674026
118MP0005390_skeleton_phenotype0.39580345
119MP0005451_abnormal_body_composition0.39465326
120MP0010307_abnormal_tumor_latency0.39412118
121MP0002928_abnormal_bile_duct0.39235126
122MP0000367_abnormal_coat/_hair0.38689426
123MP0008874_decreased_physiological_sensi0.37641053
124MP0008569_lethality_at_weaning0.36808674
125MP0005535_abnormal_body_temperature0.35962144

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.90467125
2Abnormality of T cell number (HP:0011839)7.56339036
3Stomatitis (HP:0010280)5.93920399
4Abnormality of T cells (HP:0002843)5.72075578
5Severe combined immunodeficiency (HP:0004430)5.71632733
6Panhypogammaglobulinemia (HP:0003139)5.33762682
7Combined immunodeficiency (HP:0005387)5.28729093
8Elevated erythrocyte sedimentation rate (HP:0003565)5.28183390
9Recurrent fungal infections (HP:0002841)5.19447293
10Recurrent bronchitis (HP:0002837)4.88823070
11Chronic mucocutaneous candidiasis (HP:0002728)4.68438353
12Recurrent cutaneous fungal infections (HP:0011370)4.68438353
13Chronic diarrhea (HP:0002028)4.63345680
14IgM deficiency (HP:0002850)4.53918220
15Recurrent viral infections (HP:0004429)4.52688424
16Eczematoid dermatitis (HP:0000976)4.47127838
17Nasal polyposis (HP:0100582)4.45624224
18IgG deficiency (HP:0004315)4.29415980
19Chronic otitis media (HP:0000389)4.24897775
20Abnormal delayed hypersensitivity skin test (HP:0002963)4.12753212
21Abnormality of the fingertips (HP:0001211)3.85043234
22Recurrent bacterial skin infections (HP:0005406)3.82929648
23Abnormality of T cell physiology (HP:0011840)3.81330657
24Recurrent abscess formation (HP:0002722)3.74904448
25Pustule (HP:0200039)3.73739025
26IgA deficiency (HP:0002720)3.67300493
27Abnormality of the nasal mucosa (HP:0000433)3.64366389
28Abnormality of B cell number (HP:0010975)3.62086727
29B lymphocytopenia (HP:0010976)3.62086727
30Joint swelling (HP:0001386)3.57082486
31Autoimmune hemolytic anemia (HP:0001890)3.52839806
32Abnormality of macrophages (HP:0004311)3.47352581
33Abnormality of eosinophils (HP:0001879)3.39343796
34Increased IgM level (HP:0003496)3.32924797
35Eosinophilia (HP:0001880)3.30810316
36Lymphopenia (HP:0001888)3.20005310
37Myositis (HP:0100614)3.17972541
38Leukocytosis (HP:0001974)3.14746025
39Gastrointestinal infarctions (HP:0005244)3.12829259
40Abnormality of cells of the lymphoid lineage (HP:0012140)3.12292301
41Thrombocytosis (HP:0001894)3.08824076
42Keratoconjunctivitis sicca (HP:0001097)3.08279282
43Basal cell carcinoma (HP:0002671)3.05508862
44Increased density of long bones (HP:0006392)3.05251998
45Prolonged bleeding time (HP:0003010)2.99195529
46Hemoptysis (HP:0002105)2.93399072
47Granulocytopenia (HP:0001913)2.93268050
48Keratoconjunctivitis (HP:0001096)2.91050824
49Papilledema (HP:0001085)2.84822939
50Cheilitis (HP:0100825)2.84065969
51Lymphoma (HP:0002665)2.75987142
52Bronchitis (HP:0012387)2.73019823
53Pulmonary infiltrates (HP:0002113)2.70696965
54Inflammation of the large intestine (HP:0002037)2.66270033
55Agammaglobulinemia (HP:0004432)2.64282325
56Persistence of primary teeth (HP:0006335)2.61860547
57Gastrointestinal inflammation (HP:0004386)2.61737673
58Slow saccadic eye movements (HP:0000514)2.60018246
59Recurrent gram-negative bacterial infections (HP:0005420)2.59738528
60Mediastinal lymphadenopathy (HP:0100721)2.58190834
61Increased IgE level (HP:0003212)2.55597415
62Vasculitis (HP:0002633)2.55501033
63Autoimmune thrombocytopenia (HP:0001973)2.52848281
64Thyroiditis (HP:0100646)2.43649960
65Hypoplasia of the thymus (HP:0000778)2.40820491
66Colitis (HP:0002583)2.40743170
67Recurrent sinusitis (HP:0011108)2.39598599
68Chest pain (HP:0100749)2.37654724
69Hypergammaglobulinemia (HP:0010702)2.37536523
70Spontaneous hematomas (HP:0007420)2.37399336
71Hypochromic anemia (HP:0001931)2.36459350
72Gingivitis (HP:0000230)2.35248403
73Cellulitis (HP:0100658)2.28005029
74Recurrent skin infections (HP:0001581)2.26587094
75Meningitis (HP:0001287)2.24393721
76Arterial thrombosis (HP:0004420)2.20300442
77Retrobulbar optic neuritis (HP:0100654)2.18596814
78Optic neuritis (HP:0100653)2.18596814
79Verrucae (HP:0200043)2.13073461
80Papilloma (HP:0012740)2.13073461
81Anorexia (HP:0002039)2.11974633
82Chronic sinusitis (HP:0011109)2.10300245
83Ureteral stenosis (HP:0000071)2.09763088
84Fatigue (HP:0012378)2.09060894
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08151913
86Abnormal platelet volume (HP:0011876)2.08142213
87Urticaria (HP:0001025)2.07246442
88Segmental peripheral demyelination/remyelination (HP:0003481)2.06836719
89Amaurosis fugax (HP:0100576)2.06011261
90Acute hepatic failure (HP:0006554)2.04258155
91Gangrene (HP:0100758)2.03667284
92Hypochromic microcytic anemia (HP:0004840)2.02072297
93Episodic fever (HP:0001954)2.01761661
94Microcytic anemia (HP:0001935)2.01127961
95Sepsis (HP:0100806)1.98880800
96Stomach cancer (HP:0012126)1.98467689
97Obstructive lung disease (HP:0006536)1.96376050
98Chronic obstructive pulmonary disease (HP:0006510)1.96376050
99Encephalitis (HP:0002383)1.95929890
100Hepatitis (HP:0012115)1.94324212
101Emphysema (HP:0002097)1.93807407
102Seborrheic dermatitis (HP:0001051)1.92097766
103Abnormality of the pleura (HP:0002103)1.89998698
104Restrictive lung disease (HP:0002091)1.88341821
105Poikiloderma (HP:0001029)1.88205285
106Ureteral obstruction (HP:0006000)1.87803642
107Osteomyelitis (HP:0002754)1.86083769
108Bronchiectasis (HP:0002110)1.85898593
109Epistaxis (HP:0000421)1.83526792
110Recurrent otitis media (HP:0000403)1.83439924
111Acute myeloid leukemia (HP:0004808)1.82715926
112Orchitis (HP:0100796)1.82271769
113Abnormality of the endocardium (HP:0004306)1.78718370
114Pulmonary embolism (HP:0002204)1.76814075
115Trigonocephaly (HP:0000243)1.75719167
116Skin ulcer (HP:0200042)1.74538367
117Aplasia/Hypoplasia of the thymus (HP:0010515)1.73630086
118Somatic mutation (HP:0001428)1.73439977
119Gastrointestinal stroma tumor (HP:0100723)1.72934486
120Arthralgia (HP:0002829)1.72593233
121Entropion (HP:0000621)1.72522330
122Periodontitis (HP:0000704)1.70831919
123Dislocated radial head (HP:0003083)1.70826772
124Gingival bleeding (HP:0000225)1.69732081
125Abnormality of the prostate (HP:0008775)1.68724384
126Increased mean platelet volume (HP:0011877)1.67603218
127Prominent nose (HP:0000448)1.65942811
128Bicuspid aortic valve (HP:0001647)1.65698599
129Teleangiectasia of the skin (HP:0100585)1.63799960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.99273370
2TXK5.84344744
3JAK34.02995020
4ZAP703.58335615
5PRPF4B3.44055175
6ITK3.17278064
7FGFR43.14046393
8RIPK42.54407288
9EEF2K2.46772741
10STK102.36487807
11TYK22.32200199
12MAP3K142.23812516
13IKBKE2.19732620
14NLK2.10879670
15FGFR31.95221692
16CAMKK21.79602979
17* LCK1.76764655
18CAMKK11.75572455
19GRK61.65271058
20JAK11.65024961
21TEC1.63917493
22NME21.63509001
23CDK121.54162350
24TRIB31.51508541
25TAOK31.50941772
26CSK1.49001964
27MAP3K101.47835958
28HCK1.47146032
29KDR1.42878223
30PKN21.25603334
31SYK1.25582890
32MAP3K71.24786431
33TESK21.23995622
34PRKCQ1.22393114
35SMG11.21228897
36TBK11.20289907
37TSSK61.19914681
38CHUK1.19174333
39PRKCH1.18910735
40BTK1.18336471
41IKBKB1.18280139
42ERN11.17350133
43TAOK11.10872601
44EPHA31.10445461
45SIK21.05049430
46JAK21.00846998
47MAPK111.00415529
48MAP3K130.99348830
49MARK30.97740566
50RPS6KA40.97082563
51LRRK20.94683916
52TYRO30.93024158
53MST40.92456275
54ALK0.91917633
55EPHB10.91893962
56PASK0.89209954
57MAP3K10.87169590
58MAPK120.83827054
59CLK10.80827559
60PIM10.76626149
61FGFR10.76083041
62MAP2K30.75076714
63SIK30.74169544
64MARK20.72534847
65KIT0.70719904
66BRD40.70113981
67BLK0.69544723
68CDK40.68891283
69MAP3K110.68463461
70FES0.65530607
71PDGFRB0.64836714
72TTN0.62305132
73TNK20.59418819
74CDC70.57806982
75SIK10.55929013
76TGFBR10.54747649
77KSR20.51420203
78MAP3K80.51015764
79YES10.49188413
80PDK10.47805903
81MELK0.47455067
82CAMK40.44186008
83HIPK20.44033157
84PIM20.43660608
85SGK20.43554947
86INSR0.42492271
87UHMK10.41554013
88FGR0.41200861
89CDC42BPA0.40535882
90NTRK20.39945788
91PTK60.39237281
92ROCK20.38561183
93* LYN0.38408061
94RPS6KA50.37702264
95CHEK10.37152341
96IRAK10.36970921
97IGF1R0.36462966
98* FYN0.36378674
99IRAK40.36084142
100MAP3K30.35202263
101NEK60.34915162
102RPS6KL10.34567118
103RPS6KC10.34567118
104RAF10.33159324
105RET0.32869599
106CSF1R0.31096163
107CDK60.31061380
108CDK90.30555664
109DMPK0.29975999
110RPS6KA60.29844881
111STK380.28729422
112TAOK20.28362729
113STK110.28211501
114PIK3CG0.28196345
115PDPK10.26982862
116BMPR20.26338721
117MAPK30.25568423
118MTOR0.25014281
119NEK20.24647038
120MAPKAPK20.23504450
121STK40.22561541
122TGFBR20.22104721
123SGK30.21976616
124PRKD20.20292009
125RPS6KA10.19805327
126MAPK70.18364514
127FGFR20.18344112
128ATR0.18241883

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.47802608
2T cell receptor signaling pathway_Homo sapiens_hsa046604.30039871
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.65830889
4Measles_Homo sapiens_hsa051622.93088532
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.84585381
6Allograft rejection_Homo sapiens_hsa053302.70162653
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.55516730
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.43349272
9Graft-versus-host disease_Homo sapiens_hsa053322.22907924
10Antigen processing and presentation_Homo sapiens_hsa046122.11051422
11Autoimmune thyroid disease_Homo sapiens_hsa053202.07669437
12Jak-STAT signaling pathway_Homo sapiens_hsa046301.99895077
13Viral myocarditis_Homo sapiens_hsa054161.97762574
14Type I diabetes mellitus_Homo sapiens_hsa049401.81868123
15Leishmaniasis_Homo sapiens_hsa051401.78530258
16Osteoclast differentiation_Homo sapiens_hsa043801.78397876
17Acute myeloid leukemia_Homo sapiens_hsa052211.59861621
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59125615
19Herpes simplex infection_Homo sapiens_hsa051681.57909791
20B cell receptor signaling pathway_Homo sapiens_hsa046621.57517722
21* Hematopoietic cell lineage_Homo sapiens_hsa046401.40826506
22Hepatitis B_Homo sapiens_hsa051611.37065545
23HTLV-I infection_Homo sapiens_hsa051661.37012645
24Toxoplasmosis_Homo sapiens_hsa051451.35438033
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34719511
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28829959
27Asthma_Homo sapiens_hsa053101.28258938
28Chronic myeloid leukemia_Homo sapiens_hsa052201.25625711
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25420653
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24747519
31Chemokine signaling pathway_Homo sapiens_hsa040621.22204705
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18645741
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17678290
34TNF signaling pathway_Homo sapiens_hsa046681.16753403
35Prolactin signaling pathway_Homo sapiens_hsa049171.16697823
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15627973
37Shigellosis_Homo sapiens_hsa051311.13012855
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10439319
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10112263
40Influenza A_Homo sapiens_hsa051641.08480522
41Epstein-Barr virus infection_Homo sapiens_hsa051691.07949573
42Pancreatic cancer_Homo sapiens_hsa052121.07862490
43Spliceosome_Homo sapiens_hsa030401.06247929
44Viral carcinogenesis_Homo sapiens_hsa052031.04884223
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.01160252
46Legionellosis_Homo sapiens_hsa051340.97745911
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94532955
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93245155
49One carbon pool by folate_Homo sapiens_hsa006700.92040781
50Colorectal cancer_Homo sapiens_hsa052100.88058845
51Apoptosis_Homo sapiens_hsa042100.87944810
52Ribosome_Homo sapiens_hsa030100.86228680
53RNA transport_Homo sapiens_hsa030130.86164646
54Hepatitis C_Homo sapiens_hsa051600.80896779
55Inositol phosphate metabolism_Homo sapiens_hsa005620.79132991
56VEGF signaling pathway_Homo sapiens_hsa043700.78474025
57mRNA surveillance pathway_Homo sapiens_hsa030150.77297757
58RNA degradation_Homo sapiens_hsa030180.72354182
59Choline metabolism in cancer_Homo sapiens_hsa052310.70821939
60DNA replication_Homo sapiens_hsa030300.70254377
61Small cell lung cancer_Homo sapiens_hsa052220.66783162
62Platelet activation_Homo sapiens_hsa046110.64668738
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.64603542
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60932059
65Tuberculosis_Homo sapiens_hsa051520.60543869
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59248403
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59143931
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.58999610
69Dorso-ventral axis formation_Homo sapiens_hsa043200.58807670
70Salmonella infection_Homo sapiens_hsa051320.57603101
71Thyroid cancer_Homo sapiens_hsa052160.56587653
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.56230863
73Regulation of autophagy_Homo sapiens_hsa041400.56162485
74Renal cell carcinoma_Homo sapiens_hsa052110.55670871
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55175117
76Malaria_Homo sapiens_hsa051440.54830093
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54593782
78African trypanosomiasis_Homo sapiens_hsa051430.54501283
79MAPK signaling pathway_Homo sapiens_hsa040100.53508371
80Non-homologous end-joining_Homo sapiens_hsa034500.52636559
81p53 signaling pathway_Homo sapiens_hsa041150.51848102
82Non-small cell lung cancer_Homo sapiens_hsa052230.51806024
83ErbB signaling pathway_Homo sapiens_hsa040120.51529753
84Base excision repair_Homo sapiens_hsa034100.51067315
85HIF-1 signaling pathway_Homo sapiens_hsa040660.51024339
86mTOR signaling pathway_Homo sapiens_hsa041500.49965542
87Notch signaling pathway_Homo sapiens_hsa043300.48404602
88Prostate cancer_Homo sapiens_hsa052150.47798128
89Mismatch repair_Homo sapiens_hsa034300.47066689
90Other glycan degradation_Homo sapiens_hsa005110.46878487
91Type II diabetes mellitus_Homo sapiens_hsa049300.46830342
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46667907
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.46585046
94Long-term potentiation_Homo sapiens_hsa047200.46584335
95Ras signaling pathway_Homo sapiens_hsa040140.44965877
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44558585
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44268168
98Pertussis_Homo sapiens_hsa051330.43590220
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43179463
100Glioma_Homo sapiens_hsa052140.41918995
101Insulin resistance_Homo sapiens_hsa049310.40678643
102Staphylococcus aureus infection_Homo sapiens_hsa051500.40278232
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38435614
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35841786
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35837566
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35698905
107MicroRNAs in cancer_Homo sapiens_hsa052060.35458986
108GnRH signaling pathway_Homo sapiens_hsa049120.35003757
109Endocytosis_Homo sapiens_hsa041440.34949289
110Rheumatoid arthritis_Homo sapiens_hsa053230.34833821
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33281554
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.33040994
113Endometrial cancer_Homo sapiens_hsa052130.32247225
114Lysine degradation_Homo sapiens_hsa003100.31801170
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31114318
116Cell cycle_Homo sapiens_hsa041100.29932982
117Insulin signaling pathway_Homo sapiens_hsa049100.29663573
118Phagosome_Homo sapiens_hsa041450.29036718
119FoxO signaling pathway_Homo sapiens_hsa040680.28983374
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.27545263
121Rap1 signaling pathway_Homo sapiens_hsa040150.27429423
122Pathways in cancer_Homo sapiens_hsa052000.26878277
123Nucleotide excision repair_Homo sapiens_hsa034200.26465507

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