CD3G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)9.42768304
2positive thymic T cell selection (GO:0045059)9.07250415
3negative T cell selection (GO:0043383)8.93827951
4positive T cell selection (GO:0043368)8.58266822
5negative thymic T cell selection (GO:0045060)8.43950113
6cytidine deamination (GO:0009972)8.05959637
7cytidine metabolic process (GO:0046087)8.05959637
8cytidine catabolic process (GO:0006216)8.05959637
9thymic T cell selection (GO:0045061)7.99537860
10positive regulation of gamma-delta T cell activation (GO:0046645)7.75071760
11interferon-gamma production (GO:0032609)7.44900881
12pyrimidine ribonucleoside catabolic process (GO:0046133)7.38754434
13T cell selection (GO:0045058)7.26941714
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.10772775
15DNA deamination (GO:0045006)6.90881397
16regulation of gamma-delta T cell differentiation (GO:0045586)6.66249434
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.52636862
18negative regulation of cell killing (GO:0031342)6.52636862
19regulation of isotype switching to IgG isotypes (GO:0048302)6.46698084
20* T cell receptor signaling pathway (GO:0050852)6.37629111
21regulation of T cell receptor signaling pathway (GO:0050856)6.32587376
22cellular response to interleukin-15 (GO:0071350)6.29582790
23regulation of T cell tolerance induction (GO:0002664)6.19443605
24regulation of gamma-delta T cell activation (GO:0046643)5.98996754
25leukocyte aggregation (GO:0070486)5.91662907
26response to interleukin-15 (GO:0070672)5.89229227
27regulation of antigen receptor-mediated signaling pathway (GO:0050854)5.64454199
28* T cell costimulation (GO:0031295)5.57537398
29* lymphocyte costimulation (GO:0031294)5.52509946
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.42865175
31T cell migration (GO:0072678)5.39047691
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.27038046
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.27038046
34* antigen receptor-mediated signaling pathway (GO:0050851)5.25858901
35positive regulation of tolerance induction (GO:0002645)5.07791220
36regulation of B cell receptor signaling pathway (GO:0050855)5.00411086
37positive regulation of alpha-beta T cell proliferation (GO:0046641)4.92126171
38negative regulation of T cell mediated immunity (GO:0002710)4.69343152
39sequestering of actin monomers (GO:0042989)4.69060943
40regulation of alpha-beta T cell proliferation (GO:0046640)4.67933289
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.66917686
42mast cell activation (GO:0045576)4.61691161
43positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.41699588
44positive regulation of natural killer cell mediated immunity (GO:0002717)4.41699588
45regulation of tolerance induction (GO:0002643)4.39313183
46antigen processing and presentation of endogenous antigen (GO:0019883)4.34074351
47positive regulation of calcium-mediated signaling (GO:0050850)4.24904564
48regulation of natural killer cell mediated immunity (GO:0002715)4.20923067
49regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.20923067
50positive regulation of B cell differentiation (GO:0045579)4.20348923
51negative regulation of T cell apoptotic process (GO:0070233)4.20132129
52negative regulation of T cell receptor signaling pathway (GO:0050860)4.17574275
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.17333469
54regulation of B cell differentiation (GO:0045577)4.10228453
55regulation of interleukin-2 biosynthetic process (GO:0045076)4.08539448
56positive regulation of immunoglobulin mediated immune response (GO:0002891)4.05875343
57positive regulation of B cell mediated immunity (GO:0002714)4.05875343
58negative regulation of viral genome replication (GO:0045071)4.05170477
59negative regulation by host of viral transcription (GO:0043922)4.04847410
60positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.03999772
61T cell differentiation (GO:0030217)3.98934815
62regulation of immunoglobulin mediated immune response (GO:0002889)3.98392911
63positive regulation of isotype switching (GO:0045830)3.97853606
64negative regulation of lymphocyte mediated immunity (GO:0002707)3.96586669
65tolerance induction (GO:0002507)3.96466283
66regulation of leukocyte mediated cytotoxicity (GO:0001910)3.89739935
67negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.89570523
68regulation of isotype switching (GO:0045191)3.85097300
69regulation of B cell mediated immunity (GO:0002712)3.83173156
70positive regulation of defense response to virus by host (GO:0002230)3.76517689
71negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.76090838
72Arp2/3 complex-mediated actin nucleation (GO:0034314)3.75933047
73activated T cell proliferation (GO:0050798)3.74566717
74positive regulation of cell killing (GO:0031343)3.71107241
75positive regulation of granulocyte differentiation (GO:0030854)3.63184324
76pyrimidine nucleoside catabolic process (GO:0046135)3.62872968
77cellular defense response (GO:0006968)3.62388640
78positive regulation of interleukin-8 secretion (GO:2000484)3.61641730
79regulation of cell killing (GO:0031341)3.58650262
80* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.56522899
81positive regulation of interleukin-2 production (GO:0032743)3.56175162
82regulation of response to interferon-gamma (GO:0060330)3.55858512
83regulation of lymphocyte chemotaxis (GO:1901623)3.55650709
84* T cell activation (GO:0042110)3.53705161
85regulation of regulatory T cell differentiation (GO:0045589)3.52434464
86regulation of T cell mediated cytotoxicity (GO:0001914)3.50732887
87regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.50653385
88regulation of chronic inflammatory response (GO:0002676)3.50557368
89positive regulation of DNA recombination (GO:0045911)3.49842077
90natural killer cell activation (GO:0030101)3.47518927
91regulation of immunoglobulin production (GO:0002637)3.46383593
92alpha-beta T cell differentiation (GO:0046632)3.45314601
93lymphocyte migration (GO:0072676)3.43464390
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.43139176
95positive regulation of immunoglobulin production (GO:0002639)3.42850937
96antigen processing and presentation via MHC class Ib (GO:0002475)3.42593294
97negative regulation of B cell proliferation (GO:0030889)3.41393131
98leukocyte cell-cell adhesion (GO:0007159)3.39366544
99regulation of hypersensitivity (GO:0002883)3.39318877
100chemokine-mediated signaling pathway (GO:0070098)3.38484729
101mast cell degranulation (GO:0043303)3.36408463
102mast cell activation involved in immune response (GO:0002279)3.36408463
103regulation of activation of Janus kinase activity (GO:0010533)3.35970714
104positive regulation of T cell chemotaxis (GO:0010820)3.34734108
105regulation of T cell chemotaxis (GO:0010819)3.34734108
106positive regulation of interleukin-4 production (GO:0032753)3.34105579
107regulation of defense response to virus by virus (GO:0050690)3.32540309
108actin nucleation (GO:0045010)3.32482154
109heterotypic cell-cell adhesion (GO:0034113)3.32090215
110dendritic cell chemotaxis (GO:0002407)3.31738004
111V(D)J recombination (GO:0033151)3.31124563
112alpha-beta T cell activation (GO:0046631)3.30606684
113positive regulation of T cell mediated cytotoxicity (GO:0001916)3.23374423
114regulation of interleukin-4 production (GO:0032673)3.22350264
115* positive regulation of T cell activation (GO:0050870)3.22123332
116lymphocyte chemotaxis (GO:0048247)3.20779612
117regulation of viral genome replication (GO:0045069)3.20306468
118positive regulation of lamellipodium assembly (GO:0010592)3.20025637
119regulation of lymphocyte mediated immunity (GO:0002706)3.16629020
120cellular response to interleukin-4 (GO:0071353)3.15527261
121regulation of type I interferon-mediated signaling pathway (GO:0060338)3.14427568
122negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.14015650
123positive regulation of macrophage differentiation (GO:0045651)3.11927661
124positive regulation of lymphocyte mediated immunity (GO:0002708)3.11868337
125negative regulation of B cell activation (GO:0050869)3.11773860
126B cell receptor signaling pathway (GO:0050853)3.10775385
127positive regulation of interleukin-1 beta secretion (GO:0050718)3.08846407
128positive regulation of lymphocyte migration (GO:2000403)3.08679552
129* regulation of T cell activation (GO:0050863)3.07212487
130regulation of interleukin-1 beta secretion (GO:0050706)3.06959664
131positive regulation of humoral immune response (GO:0002922)3.05642999
132regulation of calcium-mediated signaling (GO:0050848)3.05151314
133cellular response to type I interferon (GO:0071357)3.03036077
134type I interferon signaling pathway (GO:0060337)3.03036077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.70423810
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.68251611
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.08951918
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.06028863
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.96381673
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.74587642
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.72562503
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.67867490
9RUNX_20019798_ChIP-Seq_JUKART_Human3.59798752
10MYB_26560356_Chip-Seq_TH2_Human3.47702592
11MYC_22102868_ChIP-Seq_BL_Human3.33834692
12E2F7_22180533_ChIP-Seq_HELA_Human3.18671900
13MAF_26560356_Chip-Seq_TH1_Human3.09723717
14UTX_26944678_Chip-Seq_JUKART_Human3.02790786
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90627063
16MYB_26560356_Chip-Seq_TH1_Human2.85556235
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73585899
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73386142
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.52403904
20GATA3_27048872_Chip-Seq_THYMUS_Human2.27605761
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17663455
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14101761
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08594254
24* MAF_26560356_Chip-Seq_TH2_Human2.04210763
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.02788226
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.98609413
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88186138
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86500024
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85065718
30SPI1_23547873_ChIP-Seq_NB4_Human1.83068009
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.78102646
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75899940
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73647255
34VDR_22108803_ChIP-Seq_LS180_Human1.72258850
35VDR_21846776_ChIP-Seq_THP-1_Human1.71860861
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71302301
37TCF7_22412390_ChIP-Seq_EML_Mouse1.66192818
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.65719416
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61281037
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59031038
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56970665
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56945172
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52301582
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50416870
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48733210
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.42862174
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.41852085
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36827983
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36169736
50TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.33299720
51SCL_19346495_ChIP-Seq_HPC-7_Human1.32479474
52KDM2B_26808549_Chip-Seq_DND41_Human1.32011058
53VDR_24763502_ChIP-Seq_THP-1_Human1.31575250
54VDR_23849224_ChIP-Seq_CD4+_Human1.30560969
55GATA3_26560356_Chip-Seq_TH2_Human1.30249631
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29977985
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29612621
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26439638
59GATA3_26560356_Chip-Seq_TH1_Human1.20858950
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20539055
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20515346
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17834120
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.13851228
64PU_27001747_Chip-Seq_BMDM_Mouse1.13372842
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11818188
66* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11437773
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11084841
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10269882
69FOXP3_21729870_ChIP-Seq_TREG_Human1.09938980
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09842119
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06309698
72SPI1_23127762_ChIP-Seq_K562_Human1.04852760
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04446537
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03839862
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02801396
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01641181
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.01537241
78GATA1_22025678_ChIP-Seq_K562_Human0.98790271
79E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98678560
80PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98629625
81CIITA_25753668_ChIP-Seq_RAJI_Human0.97204316
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95609013
83* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95537173
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95186838
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.94922743
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94438984
87IGF1R_20145208_ChIP-Seq_DFB_Human0.93924901
88ER_23166858_ChIP-Seq_MCF-7_Human0.93168351
89TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92482819
90GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91914427
91FOXM1_23109430_ChIP-Seq_U2OS_Human0.91801486
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91415201
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90837785
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90336056
95SMRT_27268052_Chip-Seq_Bcells_Human0.88482562
96VDR_24787735_ChIP-Seq_THP-1_Human0.88431944
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87311210
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.85489634
99KDM2B_26808549_Chip-Seq_JURKAT_Human0.85209006
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84851004
101ELK3_25401928_ChIP-Seq_HUVEC_Human0.84281980
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82507742
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82012294
104ELK1_19687146_ChIP-ChIP_HELA_Human0.80949858
105ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80662788
106SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.80101589
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80076490
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79402171
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79007926
110FOXA1_25329375_ChIP-Seq_VCAP_Human0.78504309
111FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78504309
112TP63_17297297_ChIP-ChIP_HaCaT_Human0.77939924
113GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76325204
114PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75671499
115RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75506684
116FLI1_21867929_ChIP-Seq_CD8_Mouse0.75258945
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75210236
118OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75044367
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74410944
120GATA6_21074721_ChIP-Seq_CACO-2_Human0.73433724
121RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73024312
122* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.72421545
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72140425
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71904168
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71604232
126NANOG_20526341_ChIP-Seq_ESCs_Human0.71292494
127EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70895362
128TP53_22573176_ChIP-Seq_HFKS_Human0.70878045
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.70280372
130FOXA1_21572438_ChIP-Seq_LNCaP_Human0.70176135
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70120371
132FOXH1_21741376_ChIP-Seq_EPCs_Human0.70091410
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.69373542
134BCL6_27268052_Chip-Seq_Bcells_Human0.68817670
135TAF2_19829295_ChIP-Seq_ESCs_Human0.68024642
136GABP_17652178_ChIP-ChIP_JURKAT_Human0.66724214
137XRN2_22483619_ChIP-Seq_HELA_Human0.66640340
138MYC_19079543_ChIP-ChIP_MESCs_Mouse0.65570371
139* SMAD_19615063_ChIP-ChIP_OVARY_Human0.65305205
140EGR1_19032775_ChIP-ChIP_M12_Human0.63737842
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.63463260
142EST1_17652178_ChIP-ChIP_JURKAT_Human0.62896795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.46071108
2MP0005671_abnormal_response_to5.07669246
3MP0002166_altered_tumor_susceptibility3.81264027
4MP0000685_abnormal_immune_system3.52085483
5MP0002006_tumorigenesis3.37957327
6MP0001835_abnormal_antigen_presentation3.18587779
7MP0009785_altered_susceptibility_to3.00389466
8MP0001800_abnormal_humoral_immune2.99157494
9MP0005000_abnormal_immune_tolerance2.90719019
10MP0009333_abnormal_splenocyte_physiolog2.89963467
11* MP0000703_abnormal_thymus_morphology2.89710299
12* MP0002398_abnormal_bone_marrow2.84642116
13MP0006082_CNS_inflammation2.81186566
14* MP0002420_abnormal_adaptive_immunity2.76116305
15* MP0001819_abnormal_immune_cell2.75001122
16MP0002723_abnormal_immune_serum2.73134818
17MP0004381_abnormal_hair_follicle2.68701142
18MP0001790_abnormal_immune_system2.65764731
19MP0005387_immune_system_phenotype2.65764731
20MP0002009_preneoplasia2.58596117
21MP0003724_increased_susceptibility_to2.58303252
22MP0004947_skin_inflammation2.57484496
23MP0001873_stomach_inflammation2.51357162
24MP0002405_respiratory_system_inflammati2.47936361
25* MP0000716_abnormal_immune_system2.43458499
26* MP0002722_abnormal_immune_system2.43276727
27* MP0005025_abnormal_response_to2.43152063
28MP0002452_abnormal_antigen_presenting2.37563026
29MP0002933_joint_inflammation2.17288145
30MP0003866_abnormal_defecation2.14404152
31* MP0000689_abnormal_spleen_morphology2.14138139
32MP0010155_abnormal_intestine_physiology2.03340386
33MP0003300_gastrointestinal_ulcer1.99530244
34* MP0002429_abnormal_blood_cell1.92840701
35MP0002148_abnormal_hypersensitivity_rea1.90945899
36MP0002396_abnormal_hematopoietic_system1.85395777
37MP0005310_abnormal_salivary_gland1.76697340
38MP0003436_decreased_susceptibility_to1.68695905
39MP0000858_altered_metastatic_potential1.60305131
40MP0002419_abnormal_innate_immunity1.56432796
41MP0001845_abnormal_inflammatory_respons1.55099312
42MP0005464_abnormal_platelet_physiology1.50988435
43MP0001851_eye_inflammation1.50535300
44MP0002132_abnormal_respiratory_system1.45132067
45MP0004510_myositis1.43085144
46MP0001853_heart_inflammation1.41662819
47MP0002163_abnormal_gland_morphology1.41237956
48MP0002277_abnormal_respiratory_mucosa1.36947219
49MP0003448_altered_tumor_morphology1.32661109
50MP0001919_abnormal_reproductive_system1.31168184
51MP0000490_abnormal_crypts_of1.18120723
52MP0005075_abnormal_melanosome_morpholog1.18021887
53MP0002019_abnormal_tumor_incidence1.12158098
54MP0008469_abnormal_protein_level1.02589091
55MP0000569_abnormal_digit_pigmentation0.98697955
56MP0002876_abnormal_thyroid_physiology0.96176481
57MP0001348_abnormal_lacrimal_gland0.90330988
58MP0010234_abnormal_vibrissa_follicle0.88208826
59MP0003786_premature_aging0.86929279
60MP0008872_abnormal_physiological_respon0.86625515
61MP0010352_gastrointestinal_tract_polyps0.84035295
62MP0005645_abnormal_hypothalamus_physiol0.83922091
63MP0005023_abnormal_wound_healing0.82842111
64MP0004808_abnormal_hematopoietic_stem0.82394244
65MP0003303_peritoneal_inflammation0.82331880
66MP0000465_gastrointestinal_hemorrhage0.80919138
67MP0001533_abnormal_skeleton_physiology0.79522141
68MP0005389_reproductive_system_phenotype0.78191944
69MP0009763_increased_sensitivity_to0.77291333
70MP0002638_abnormal_pupillary_reflex0.75784895
71MP0002998_abnormal_bone_remodeling0.73725410
72MP0003252_abnormal_bile_duct0.69795397
73MP0000477_abnormal_intestine_morphology0.68876040
74MP0001243_abnormal_dermal_layer0.67298760
75MP0001765_abnormal_ion_homeostasis0.65926816
76MP0001501_abnormal_sleep_pattern0.63142079
77MP0000015_abnormal_ear_pigmentation0.61843718
78MP0009765_abnormal_xenobiotic_induced0.61537704
79MP0001216_abnormal_epidermal_layer0.61064607
80MP0010094_abnormal_chromosome_stability0.59599985
81MP0005670_abnormal_white_adipose0.59308732
82MP0009764_decreased_sensitivity_to0.59097828
83MP0003045_fibrosis0.58311470
84MP0002693_abnormal_pancreas_physiology0.57846153
85MP0003693_abnormal_embryo_hatching0.57262805
86MP0004130_abnormal_muscle_cell0.57158650
87MP0000627_abnormal_mammary_gland0.57141303
88MP0008057_abnormal_DNA_replication0.56823001
89MP0000609_abnormal_liver_physiology0.56494310
90MP0003453_abnormal_keratinocyte_physiol0.56461003
91MP0005451_abnormal_body_composition0.56045683
92MP0001986_abnormal_taste_sensitivity0.55950861
93MP0001191_abnormal_skin_condition0.55236834
94MP0002098_abnormal_vibrissa_morphology0.55092597
95MP0002136_abnormal_kidney_physiology0.54885824
96MP0000367_abnormal_coat/_hair0.54441855
97MP0001545_abnormal_hematopoietic_system0.54350183
98MP0005397_hematopoietic_system_phenotyp0.54350183
99MP0001881_abnormal_mammary_gland0.54190832
100MP0003787_abnormal_imprinting0.53082698
101MP0002102_abnormal_ear_morphology0.52891958
102MP0005174_abnormal_tail_pigmentation0.52239371
103MP0002138_abnormal_hepatobiliary_system0.50375437
104MP0006072_abnormal_retinal_apoptosis0.49766699
105MP0004957_abnormal_blastocyst_morpholog0.49690397
106MP0000372_irregular_coat_pigmentation0.49341462
107MP0009643_abnormal_urine_homeostasis0.48780922
108MP0008961_abnormal_basal_metabolism0.48543450
109MP0001905_abnormal_dopamine_level0.47014985
110MP0003077_abnormal_cell_cycle0.46537498
111MP0003795_abnormal_bone_structure0.46312058
112MP0002822_catalepsy0.45644983
113MP0003646_muscle_fatigue0.44174711
114MP0004134_abnormal_chest_morphology0.43845235
115MP0005551_abnormal_eye_electrophysiolog0.42869027
116MP0002095_abnormal_skin_pigmentation0.42651378
117MP0005379_endocrine/exocrine_gland_phen0.41719343
118MP0004142_abnormal_muscle_tone0.41152307
119MP0008877_abnormal_DNA_methylation0.41097886
120MP0000249_abnormal_blood_vessel0.40856494
121MP0005636_abnormal_mineral_homeostasis0.40165378
122MP0001119_abnormal_female_reproductive0.40088178
123MP0008873_increased_physiological_sensi0.39774647
124MP0003195_calcinosis0.39605118
125MP0002083_premature_death0.39417346
126MP0005253_abnormal_eye_physiology0.39275104
127MP0005390_skeleton_phenotype0.39228549
128MP0008007_abnormal_cellular_replicative0.38231619
129MP0005076_abnormal_cell_differentiation0.37615023
130MP0005166_decreased_susceptibility_to0.36397171
131MP0001663_abnormal_digestive_system0.36152428
132MP0003959_abnormal_lean_body0.35513729

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)8.48287575
2T lymphocytopenia (HP:0005403)8.45652591
3Severe combined immunodeficiency (HP:0004430)7.39250635
4Stomatitis (HP:0010280)7.03355642
5Combined immunodeficiency (HP:0005387)6.77972346
6Elevated erythrocyte sedimentation rate (HP:0003565)6.25476284
7Abnormality of T cells (HP:0002843)5.89298271
8IgG deficiency (HP:0004315)5.52282331
9Increased IgM level (HP:0003496)5.19020938
10Recurrent bronchitis (HP:0002837)5.02134946
11Thyroiditis (HP:0100646)4.87890724
12Abnormality of eosinophils (HP:0001879)4.81054182
13Myositis (HP:0100614)4.63172636
14B lymphocytopenia (HP:0010976)4.44331821
15Abnormality of B cell number (HP:0010975)4.44331821
16IgM deficiency (HP:0002850)4.36082875
17Hypoplasia of the thymus (HP:0000778)4.34268710
18Eosinophilia (HP:0001880)4.32265450
19Panhypogammaglobulinemia (HP:0003139)4.30476180
20Recurrent fungal infections (HP:0002841)4.28911741
21Abnormality of cells of the lymphoid lineage (HP:0012140)4.21232931
22Lymphopenia (HP:0001888)4.21010231
23Retrobulbar optic neuritis (HP:0100654)3.94206903
24Optic neuritis (HP:0100653)3.94206903
25Leukocytosis (HP:0001974)3.91202531
26Chronic mucocutaneous candidiasis (HP:0002728)3.85598246
27Recurrent cutaneous fungal infections (HP:0011370)3.85598246
28Chronic diarrhea (HP:0002028)3.81214788
29Recurrent viral infections (HP:0004429)3.80188589
30Eczematoid dermatitis (HP:0000976)3.78271855
31Nasal polyposis (HP:0100582)3.68246914
32Abnormality of T cell physiology (HP:0011840)3.64960364
33Orchitis (HP:0100796)3.63895220
34Granulocytopenia (HP:0001913)3.60685755
35Aplastic anemia (HP:0001915)3.60046482
36Joint swelling (HP:0001386)3.54019247
37Abnormal delayed hypersensitivity skin test (HP:0002963)3.39093179
38Chronic otitis media (HP:0000389)3.33323474
39Abnormality of the nasal mucosa (HP:0000433)3.06119269
40Pustule (HP:0200039)3.04779190
41Pulmonary infiltrates (HP:0002113)3.03460454
42Vasculitis (HP:0002633)3.01844855
43Gastrointestinal infarctions (HP:0005244)3.00962310
44Meningitis (HP:0001287)3.00243680
45Hypergammaglobulinemia (HP:0010702)2.97323928
46Hemoptysis (HP:0002105)2.95948721
47Autoimmune thrombocytopenia (HP:0001973)2.89165110
48Abnormality of binocular vision (HP:0011514)2.85765027
49Diplopia (HP:0000651)2.85765027
50Recurrent otitis media (HP:0000403)2.84680307
51Keratoconjunctivitis sicca (HP:0001097)2.83095744
52Lymphoma (HP:0002665)2.82127087
53Bronchitis (HP:0012387)2.77854906
54Abnormality of the fingertips (HP:0001211)2.76580840
55IgA deficiency (HP:0002720)2.66086383
56Encephalitis (HP:0002383)2.66021213
57Muscle fiber atrophy (HP:0100295)2.62902143
58Recurrent sinusitis (HP:0011108)2.62238138
59Keratoconjunctivitis (HP:0001096)2.55778080
60Mediastinal lymphadenopathy (HP:0100721)2.50057270
61Abnormality of macrophages (HP:0004311)2.49296241
62Abnormality of male internal genitalia (HP:0000022)2.48611610
63Pulmonary fibrosis (HP:0002206)2.48603595
64Hypoproteinemia (HP:0003075)2.48458018
65Abnormality of the prostate (HP:0008775)2.43696073
66Chronic obstructive pulmonary disease (HP:0006510)2.41207606
67Obstructive lung disease (HP:0006536)2.41207606
68Hemiplegia (HP:0002301)2.37599519
69Gangrene (HP:0100758)2.35130613
70Arterial thrombosis (HP:0004420)2.33807182
71Agammaglobulinemia (HP:0004432)2.29092107
72Congenital stationary night blindness (HP:0007642)2.29067048
73Pulmonary embolism (HP:0002204)2.22183412
74Abnormal albumin level (HP:0012116)2.20377302
75Hypoalbuminemia (HP:0003073)2.20377302
76Pancytopenia (HP:0001876)2.15635140
77Papilledema (HP:0001085)2.12246913
78Recurrent skin infections (HP:0001581)2.11642159
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11399942
80* Autoimmune hemolytic anemia (HP:0001890)2.10624807
81Acute hepatic failure (HP:0006554)2.08198767
82Recurrent abscess formation (HP:0002722)2.05023710
83Recurrent bacterial skin infections (HP:0005406)2.04839412
84Aplasia/Hypoplasia of the thymus (HP:0010515)2.04788920
85Skin rash (HP:0000988)2.02665856
86Ureteral stenosis (HP:0000071)2.00154522
87Genetic anticipation (HP:0003743)1.98769509
88Anorexia (HP:0002039)1.98194017
89Reduced subcutaneous adipose tissue (HP:0003758)1.95564549
90Basal cell carcinoma (HP:0002671)1.94213368
91Spontaneous hematomas (HP:0007420)1.89644790
92Papilloma (HP:0012740)1.88761102
93Verrucae (HP:0200043)1.88761102
94Premature graying of hair (HP:0002216)1.83506972
95Increased IgE level (HP:0003212)1.82897942
96Prostate neoplasm (HP:0100787)1.82877423
97Abnormality of the pericardium (HP:0001697)1.82671780
983-Methylglutaconic aciduria (HP:0003535)1.81990757
99Chest pain (HP:0100749)1.80146752
100Inflammation of the large intestine (HP:0002037)1.80067649
101Amyotrophic lateral sclerosis (HP:0007354)1.79726292
102Alveolar cell carcinoma (HP:0006519)1.79507699
103Ureteral obstruction (HP:0006000)1.79446055
104Polyneuropathy (HP:0001271)1.78846233
105Keratitis (HP:0000491)1.77322130
106Renal cortical cysts (HP:0000803)1.77006669
107Thrombocytosis (HP:0001894)1.76363187
108Amaurosis fugax (HP:0100576)1.75845798
109Epistaxis (HP:0000421)1.75218116
110Gastrointestinal inflammation (HP:0004386)1.73995390
111Abnormality of the pleura (HP:0002103)1.73070505
112Abnormal rod and cone electroretinograms (HP:0008323)1.73009148
113Arthralgia (HP:0002829)1.73005115
114Cheilitis (HP:0100825)1.71083619
115Glomerulopathy (HP:0100820)1.69767003
116Abnormal number of erythroid precursors (HP:0012131)1.65973598
117Type 2 muscle fiber atrophy (HP:0003554)1.65774971
118Bronchiectasis (HP:0002110)1.65288936
119Chronic sinusitis (HP:0011109)1.64717049
120Stomach cancer (HP:0012126)1.64505013
121Hypochromic anemia (HP:0001931)1.63798863
122Abnormality of cells of the erythroid lineage (HP:0012130)1.63767194
123Gingivitis (HP:0000230)1.63364009
124Entropion (HP:0000621)1.61918502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.71420553
2MAP4K15.35180695
3ZAP703.80557005
4ITK3.52054119
5FGFR43.02858138
6TESK22.87322885
7KDR2.81122579
8IKBKE2.79624342
9TAOK32.37630253
10JAK32.31186762
11LCK2.19472593
12MST42.17074964
13GRK62.15518856
14TYK22.14625293
15STK102.11762979
16NLK1.92304687
17TBK11.91818399
18JAK11.88336503
19ADRBK21.79767789
20FGFR31.78117001
21CSK1.75355543
22TEC1.72812756
23CAMKK21.72086515
24MAP3K141.70538185
25SYK1.68468842
26FRK1.68362022
27MAP3K121.67552856
28HCK1.52012093
29BRD41.50807712
30BLK1.45241730
31GRK71.44690577
32NME21.37173014
33BTK1.36489745
34SIK31.34921818
35EEF2K1.33198262
36NUAK11.25236218
37MAP3K101.16913737
38CLK11.15561343
39RIPK41.14322644
40TNK21.14237046
41PRKCQ1.14120502
42PRKCH1.09544193
43CDK31.05942308
44TLK11.04688175
45BUB11.03748110
46PIK3CA1.00497726
47TESK11.00401867
48GRK10.99762953
49LRRK20.98691950
50CDK40.95772253
51ZAK0.94941585
52MAP3K130.93181673
53KIT0.93117666
54MAPKAPK30.93030984
55PIK3CG0.92296577
56LYN0.91348995
57CAMKK10.85754208
58IKBKB0.83203620
59IRAK40.73401172
60PIM10.71101597
61FGFR10.70978648
62MAP3K70.70178075
63BMPR1B0.69914866
64TRIM280.68528593
65INSR0.68340914
66EIF2AK10.67798246
67BCKDK0.67284837
68VRK10.64733038
69CDK80.62948561
70JAK20.60036065
71PDGFRB0.59499246
72WNK40.57716491
73FGFR20.54407368
74BCR0.54243632
75CDK90.53288349
76HIPK20.53067737
77* FYN0.52952397
78TYRO30.51233637
79FES0.50833196
80AKT30.50391263
81CHUK0.50364190
82TAOK10.47322184
83STK40.47167822
84MAP4K20.46974359
85TSSK60.45056616
86CDK60.44472053
87PRKD20.41602462
88MAPK110.39862715
89TRPM70.39802214
90MARK20.37678624
91MAPK130.37132941
92RPS6KA40.36959366
93DYRK1B0.36146708
94RPS6KB20.35506506
95GRK50.33755858
96MYLK0.33262311
97RIPK10.32721949
98SIK20.30799912
99MAP2K60.30075953
100TGFBR20.29076640
101MAPK70.27422334
102INSRR0.26721259
103PDK10.26432799
104AURKB0.25256342
105DAPK10.25152731
106CSF1R0.24896488
107LIMK10.24561456
108CDC70.23615030
109ERBB30.23136314
110NEK20.23020077
111MAP3K110.22760102
112NEK60.22240777
113BMPR20.22208313
114PKN20.21805224
115IRAK10.21646992
116VRK20.21079298
117ILK0.21013739
118SRC0.20631351
119MARK30.20546930
120MAPK30.20390893
121ACVR1B0.20123254
122PINK10.19878882
123* PRKCA0.19177589
124EIF2AK30.18992268
125ABL10.17953981
126PASK0.17301518
127* IGF1R0.16762384
128RPS6KB10.16277677
129CDK120.15812548
130PRKCD0.14941284
131CSNK1D0.14705286
132DYRK30.14500040
133NTRK20.14151219
134RPS6KA50.13709744
135SRPK10.13696494
136MAPKAPK20.13442120

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.15634751
2Graft-versus-host disease_Homo sapiens_hsa053325.48852219
3* T cell receptor signaling pathway_Homo sapiens_hsa046604.00666234
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.99064059
5Antigen processing and presentation_Homo sapiens_hsa046123.57394162
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.95584360
7Allograft rejection_Homo sapiens_hsa053302.92315510
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.74488065
9* Measles_Homo sapiens_hsa051622.71035267
10* Hematopoietic cell lineage_Homo sapiens_hsa046402.32403395
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.23235830
12Autoimmune thyroid disease_Homo sapiens_hsa053202.21373502
13Viral myocarditis_Homo sapiens_hsa054161.74200181
14Ribosome_Homo sapiens_hsa030101.68133796
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55983678
16Leishmaniasis_Homo sapiens_hsa051401.48379235
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45618926
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.45104918
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43208721
20Osteoclast differentiation_Homo sapiens_hsa043801.40680084
21Asthma_Homo sapiens_hsa053101.35797836
22Non-homologous end-joining_Homo sapiens_hsa034501.35592452
23Herpes simplex infection_Homo sapiens_hsa051681.30030341
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.22602389
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22453462
26* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19022257
27Chemokine signaling pathway_Homo sapiens_hsa040621.13252027
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10108824
29B cell receptor signaling pathway_Homo sapiens_hsa046621.04258872
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03702328
31Type I diabetes mellitus_Homo sapiens_hsa049401.03292350
32* HTLV-I infection_Homo sapiens_hsa051661.02638386
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00044485
34Linoleic acid metabolism_Homo sapiens_hsa005910.98115115
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97287275
36Oxidative phosphorylation_Homo sapiens_hsa001900.95243991
37Hepatitis B_Homo sapiens_hsa051610.92765848
38Shigellosis_Homo sapiens_hsa051310.91930587
39Phototransduction_Homo sapiens_hsa047440.89421757
40Toxoplasmosis_Homo sapiens_hsa051450.89226427
41Nitrogen metabolism_Homo sapiens_hsa009100.86579420
42Spliceosome_Homo sapiens_hsa030400.86173203
43Apoptosis_Homo sapiens_hsa042100.82722590
44Malaria_Homo sapiens_hsa051440.77717696
45Influenza A_Homo sapiens_hsa051640.77682675
46Colorectal cancer_Homo sapiens_hsa052100.74935442
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72693042
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70923351
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70728616
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70306012
51Acute myeloid leukemia_Homo sapiens_hsa052210.69744676
52Parkinsons disease_Homo sapiens_hsa050120.68133211
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66799600
54DNA replication_Homo sapiens_hsa030300.65383228
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64635478
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64308087
57Proteasome_Homo sapiens_hsa030500.64145929
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64094658
59Pancreatic cancer_Homo sapiens_hsa052120.63967146
60Viral carcinogenesis_Homo sapiens_hsa052030.62838737
61Epstein-Barr virus infection_Homo sapiens_hsa051690.62643708
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61808189
63Staphylococcus aureus infection_Homo sapiens_hsa051500.61525278
64Platelet activation_Homo sapiens_hsa046110.60468975
65p53 signaling pathway_Homo sapiens_hsa041150.59003534
66Hepatitis C_Homo sapiens_hsa051600.54501559
67TNF signaling pathway_Homo sapiens_hsa046680.52590910
68Non-small cell lung cancer_Homo sapiens_hsa052230.51811241
69Salmonella infection_Homo sapiens_hsa051320.50893621
70Regulation of autophagy_Homo sapiens_hsa041400.50615100
71VEGF signaling pathway_Homo sapiens_hsa043700.49930440
72Legionellosis_Homo sapiens_hsa051340.47932656
73Thyroid cancer_Homo sapiens_hsa052160.45692185
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44262046
75Olfactory transduction_Homo sapiens_hsa047400.43954895
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43943960
77Adherens junction_Homo sapiens_hsa045200.42754144
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42559658
79Mismatch repair_Homo sapiens_hsa034300.41827374
80Basal transcription factors_Homo sapiens_hsa030220.41052310
81Alzheimers disease_Homo sapiens_hsa050100.39343961
82Nucleotide excision repair_Homo sapiens_hsa034200.39247364
83Tuberculosis_Homo sapiens_hsa051520.38134844
84Chronic myeloid leukemia_Homo sapiens_hsa052200.37011361
85Systemic lupus erythematosus_Homo sapiens_hsa053220.35638724
86Endocytosis_Homo sapiens_hsa041440.35484701
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34962360
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.33863554
89Ether lipid metabolism_Homo sapiens_hsa005650.32846444
90RNA degradation_Homo sapiens_hsa030180.32271711
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31702699
92Collecting duct acid secretion_Homo sapiens_hsa049660.31384326
93Prolactin signaling pathway_Homo sapiens_hsa049170.29839681
94Base excision repair_Homo sapiens_hsa034100.27724432
95Caffeine metabolism_Homo sapiens_hsa002320.26777995
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26696398
97Rheumatoid arthritis_Homo sapiens_hsa053230.26336730
98Peroxisome_Homo sapiens_hsa041460.25572906
99Dorso-ventral axis formation_Homo sapiens_hsa043200.25266751
100FoxO signaling pathway_Homo sapiens_hsa040680.25024265
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24996576
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24736914
103Rap1 signaling pathway_Homo sapiens_hsa040150.24437710
104Notch signaling pathway_Homo sapiens_hsa043300.21830740
105Pertussis_Homo sapiens_hsa051330.21244292
106Morphine addiction_Homo sapiens_hsa050320.20655364
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.19890447
108Small cell lung cancer_Homo sapiens_hsa052220.19772369
109Protein export_Homo sapiens_hsa030600.19237936
110Circadian rhythm_Homo sapiens_hsa047100.18828476
111ABC transporters_Homo sapiens_hsa020100.18734035
112African trypanosomiasis_Homo sapiens_hsa051430.18295350
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.16151001
114MAPK signaling pathway_Homo sapiens_hsa040100.14673615
115RNA polymerase_Homo sapiens_hsa030200.14312667
116Huntingtons disease_Homo sapiens_hsa050160.13337942
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12608621
118Pyrimidine metabolism_Homo sapiens_hsa002400.11899156
119Pathways in cancer_Homo sapiens_hsa052000.11373926
120Pentose phosphate pathway_Homo sapiens_hsa000300.11358817
121Inositol phosphate metabolism_Homo sapiens_hsa005620.10679841
122Cell cycle_Homo sapiens_hsa041100.09760928
123Retinol metabolism_Homo sapiens_hsa008300.09465969
124Endometrial cancer_Homo sapiens_hsa052130.09382002
125Other glycan degradation_Homo sapiens_hsa005110.09312010
126mRNA surveillance pathway_Homo sapiens_hsa030150.08831249
127Prostate cancer_Homo sapiens_hsa052150.07384751
128Renin secretion_Homo sapiens_hsa049240.06952977
129Calcium signaling pathway_Homo sapiens_hsa040200.06940053
130Taste transduction_Homo sapiens_hsa047420.06851832
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06688835
132Homologous recombination_Homo sapiens_hsa034400.06619166
133Ras signaling pathway_Homo sapiens_hsa040140.06346594
134Fanconi anemia pathway_Homo sapiens_hsa034600.06029081

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