CD302

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.74172845
2L-phenylalanine catabolic process (GO:0006559)6.74172845
3L-phenylalanine metabolic process (GO:0006558)6.40526751
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.40526751
5aromatic amino acid family catabolic process (GO:0009074)6.19649600
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.17862515
7tryptophan catabolic process (GO:0006569)5.71774952
8indole-containing compound catabolic process (GO:0042436)5.71774952
9indolalkylamine catabolic process (GO:0046218)5.71774952
10kynurenine metabolic process (GO:0070189)5.47718298
11bile acid biosynthetic process (GO:0006699)5.44634166
12tryptophan metabolic process (GO:0006568)5.44458874
13peptidyl-glutamic acid carboxylation (GO:0017187)5.42666104
14protein carboxylation (GO:0018214)5.42666104
15complement activation, alternative pathway (GO:0006957)5.41586779
16urea cycle (GO:0000050)5.30610046
17urea metabolic process (GO:0019627)5.30610046
18high-density lipoprotein particle remodeling (GO:0034375)5.29710420
19glyoxylate metabolic process (GO:0046487)5.21515036
20detection of molecule of bacterial origin (GO:0032490)5.20690929
21regulation of protein activation cascade (GO:2000257)5.16054414
22negative regulation of fibrinolysis (GO:0051918)5.15788561
23alpha-linolenic acid metabolic process (GO:0036109)5.15486536
24positive regulation by symbiont of host defense response (GO:0052509)5.05736876
25modulation by symbiont of host defense response (GO:0052031)5.05736876
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.05736876
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.05736876
28positive regulation by organism of defense response of other organism involved in symbiotic interact5.05736876
29modulation by symbiont of host immune response (GO:0052553)5.05736876
30regulation of fibrinolysis (GO:0051917)5.04684521
31neutrophil activation involved in immune response (GO:0002283)4.95192840
32positive regulation of gamma-delta T cell activation (GO:0046645)4.94912384
33response to peptidoglycan (GO:0032494)4.90527200
34nitrogen cycle metabolic process (GO:0071941)4.87496642
35sulfur amino acid catabolic process (GO:0000098)4.87010199
36regulation of cholesterol esterification (GO:0010872)4.85349301
37regulation of complement activation (GO:0030449)4.85226243
38reverse cholesterol transport (GO:0043691)4.79990208
39detection of other organism (GO:0098543)4.76426295
40cysteine metabolic process (GO:0006534)4.74435421
41regulation of triglyceride catabolic process (GO:0010896)4.70836736
42protein-lipid complex remodeling (GO:0034368)4.70274131
43macromolecular complex remodeling (GO:0034367)4.70274131
44plasma lipoprotein particle remodeling (GO:0034369)4.70274131
45macrophage activation involved in immune response (GO:0002281)4.64299077
46bile acid metabolic process (GO:0008206)4.59632607
47detection of external biotic stimulus (GO:0098581)4.59301436
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.58635137
49phospholipid efflux (GO:0033700)4.58201337
50plasma lipoprotein particle clearance (GO:0034381)4.55436643
51homocysteine metabolic process (GO:0050667)4.53488138
52aromatic amino acid family metabolic process (GO:0009072)4.46675616
53serine family amino acid catabolic process (GO:0009071)4.46674981
54tyrosine metabolic process (GO:0006570)4.42992899
55cellular extravasation (GO:0045123)4.40673480
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.37240154
57detection of bacterium (GO:0016045)4.34677588
58triglyceride homeostasis (GO:0070328)4.32708840
59acylglycerol homeostasis (GO:0055090)4.32708840
60negative regulation of cholesterol transport (GO:0032375)4.21318648
61negative regulation of sterol transport (GO:0032372)4.21318648
62microglial cell activation (GO:0001774)4.20400738
63amino-acid betaine metabolic process (GO:0006577)4.18694367
64aldehyde catabolic process (GO:0046185)4.18172263
65cholesterol efflux (GO:0033344)4.17919576
66detection of biotic stimulus (GO:0009595)4.11938394
67negative regulation of cell killing (GO:0031342)4.11795191
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11795191
69alpha-amino acid catabolic process (GO:1901606)4.10208253
70low-density lipoprotein particle remodeling (GO:0034374)4.09758774
71cellular glucuronidation (GO:0052695)4.08183634
72indolalkylamine metabolic process (GO:0006586)4.07489451
73fibrinolysis (GO:0042730)4.06569661
74cellular biogenic amine catabolic process (GO:0042402)4.06084372
75amine catabolic process (GO:0009310)4.06084372
76lysine catabolic process (GO:0006554)4.01660731
77lysine metabolic process (GO:0006553)4.01660731
78negative regulation of interleukin-12 production (GO:0032695)3.93584790
79bile acid and bile salt transport (GO:0015721)3.92596846
80positive regulation of lipid catabolic process (GO:0050996)3.90066545
81plasma lipoprotein particle assembly (GO:0034377)3.87759795
82cellular ketone body metabolic process (GO:0046950)3.87688019
83macrophage activation (GO:0042116)3.87271028
84coenzyme catabolic process (GO:0009109)3.86014754
85benzene-containing compound metabolic process (GO:0042537)3.84901932
86regulation of interferon-beta biosynthetic process (GO:0045357)3.80760866
87uronic acid metabolic process (GO:0006063)3.79672497
88glucuronate metabolic process (GO:0019585)3.79672497
89immunoglobulin mediated immune response (GO:0016064)3.77357133
90cellular amino acid catabolic process (GO:0009063)3.77063457
91arginine metabolic process (GO:0006525)3.73772640
92imidazole-containing compound metabolic process (GO:0052803)3.73373934
93cofactor catabolic process (GO:0051187)3.72045993
94acute-phase response (GO:0006953)3.71308665
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.69059441
96complement activation (GO:0006956)3.68407349
97protein activation cascade (GO:0072376)3.68011427
98positive regulation of triglyceride lipase activity (GO:0061365)3.67374137
99positive regulation of lipoprotein lipase activity (GO:0051006)3.67374137
100plasma lipoprotein particle organization (GO:0071827)3.66425393
101positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.65888965
102regulation of gamma-delta T cell activation (GO:0046643)3.65876904
103phospholipid homeostasis (GO:0055091)3.65583617
104cellular modified amino acid catabolic process (GO:0042219)3.64858246
105antigen processing and presentation of endogenous antigen (GO:0019883)3.64451684
106blood coagulation, intrinsic pathway (GO:0007597)3.64294782
107glutamate metabolic process (GO:0006536)3.63903400
108very-low-density lipoprotein particle assembly (GO:0034379)3.62740699
109opsonization (GO:0008228)3.61248473
110complement activation, classical pathway (GO:0006958)3.59262606
111response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.59157310
112response to host immune response (GO:0052572)3.59157310
113dicarboxylic acid biosynthetic process (GO:0043650)3.58215948
114glycine metabolic process (GO:0006544)3.57454655
115regulation of B cell receptor signaling pathway (GO:0050855)3.56023611
116cholesterol homeostasis (GO:0042632)3.52850640
117ethanol oxidation (GO:0006069)3.52306617
118NAD biosynthetic process (GO:0009435)3.50388991
119serine family amino acid metabolic process (GO:0009069)3.49411694
120protein-lipid complex assembly (GO:0065005)3.48176851
121sterol homeostasis (GO:0055092)3.48090415
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.47795451
123neutrophil activation (GO:0042119)3.47556656
124drug catabolic process (GO:0042737)3.46303372
125negative regulation of lipase activity (GO:0060192)3.46035239
126protein-lipid complex subunit organization (GO:0071825)3.44818162
127nicotinamide nucleotide biosynthetic process (GO:0019359)3.44094075
128pyridine nucleotide biosynthetic process (GO:0019363)3.44094075
129positive regulation of mast cell activation (GO:0033005)3.43481688
130positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.43187915
131lipoprotein metabolic process (GO:0042157)3.41127061
132neutrophil mediated immunity (GO:0002446)3.40015702
133regulation of mast cell degranulation (GO:0043304)3.36840165
134organic acid catabolic process (GO:0016054)3.36447676
135carboxylic acid catabolic process (GO:0046395)3.36447676
136regulation of plasminogen activation (GO:0010755)3.35713919
137regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.35184247
138myeloid cell activation involved in immune response (GO:0002275)3.33667781
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28755448
140response to host (GO:0075136)3.28755448
141response to host defenses (GO:0052200)3.28755448
142granulocyte activation (GO:0036230)3.21633829
143antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.20725561
144regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19447770
145positive regulation of mast cell degranulation (GO:0043306)3.18702792
146positive regulation of mast cell activation involved in immune response (GO:0033008)3.18702792
147negative regulation of lymphocyte mediated immunity (GO:0002707)3.17486720
148regulation of gamma-delta T cell differentiation (GO:0045586)3.14338402
149regulation of mast cell activation involved in immune response (GO:0033006)3.11708756
150regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.09679976
151leukocyte migration involved in inflammatory response (GO:0002523)3.08848788
152positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.08654776
153respiratory burst (GO:0045730)3.04589125
154regulation of mast cell activation (GO:0033003)3.02002607
155positive regulation of cellular amide metabolic process (GO:0034250)3.00744853
156killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.98419353
157disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.98419353
158response to muramyl dipeptide (GO:0032495)2.98236011
159negative regulation of erythrocyte differentiation (GO:0045647)2.96743541
160regulation of leukocyte degranulation (GO:0043300)2.96106102
161negative regulation of protein activation cascade (GO:2000258)2.94359846
162lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93302953
163regulation of interleukin-8 biosynthetic process (GO:0045414)2.92941892
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84377779
165negative regulation of complement activation (GO:0045916)2.84265786
166production of molecular mediator involved in inflammatory response (GO:0002532)2.82847521
167myeloid leukocyte mediated immunity (GO:0002444)2.82737423
168positive regulation of B cell differentiation (GO:0045579)2.81231150
169B cell mediated immunity (GO:0019724)2.79713126
170negative regulation of leukocyte mediated immunity (GO:0002704)2.79639970
171negative regulation of humoral immune response (GO:0002921)2.78032308
172T-helper 1 type immune response (GO:0042088)2.77530040
173interferon-gamma-mediated signaling pathway (GO:0060333)2.75999020
174negative regulation of T cell mediated immunity (GO:0002710)2.74476832
175antigen processing and presentation via MHC class Ib (GO:0002475)2.72794432
176regulation of tolerance induction (GO:0002643)2.72244318
177regulation of growth of symbiont in host (GO:0044126)2.68627213
178negative regulation of growth of symbiont in host (GO:0044130)2.68627213
179negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.68627213
180modulation of growth of symbiont involved in interaction with host (GO:0044144)2.68627213
181leukocyte aggregation (GO:0070486)2.66904237
182regulation of humoral immune response (GO:0002920)2.66812959
183regulation of macrophage cytokine production (GO:0010935)2.62850156
184defense response to protozoan (GO:0042832)2.60858506
185negative regulation of cytokine production involved in immune response (GO:0002719)2.60436999
186positive regulation of leukocyte degranulation (GO:0043302)2.60026300
187positive regulation of interferon-alpha production (GO:0032727)2.59285290
188positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59141104
189positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56851799
190B cell receptor signaling pathway (GO:0050853)2.56523921
191epoxygenase P450 pathway (GO:0019373)2.56048752
192negative regulation of interleukin-6 production (GO:0032715)2.55406654
193myeloid leukocyte activation (GO:0002274)2.55199664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.55730446
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.49343735
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.40689472
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.91902347
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.85156876
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.84271501
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.64343167
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.60712906
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.52717059
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.42350839
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15658301
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13813617
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59113174
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.47896355
15SCL_19346495_ChIP-Seq_HPC-7_Human2.36851204
16RUNX_20019798_ChIP-Seq_JUKART_Human2.32935066
17VDR_24763502_ChIP-Seq_THP-1_Human2.26723196
18SPI1_23547873_ChIP-Seq_NB4_Human2.22518731
19SPI1_23127762_ChIP-Seq_K562_Human2.21871761
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.15019423
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00272558
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7411864
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93449677
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.91935450
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89565822
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83804922
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83079168
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81826421
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78753861
30MYB_26560356_Chip-Seq_TH2_Human1.76339460
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76008194
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75564238
33VDR_21846776_ChIP-Seq_THP-1_Human1.71336250
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70837322
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70641069
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67650369
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67284117
38CLOCK_20551151_ChIP-Seq_293T_Human1.67147486
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.65714256
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.60907461
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49929637
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.49579332
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48263146
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47962320
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44191303
46MYB_26560356_Chip-Seq_TH1_Human1.42627279
47GATA1_22025678_ChIP-Seq_K562_Human1.41607017
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40583608
49MAF_26560356_Chip-Seq_TH1_Human1.39223971
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.37757915
51PU_27001747_Chip-Seq_BMDM_Mouse1.37322305
52HTT_18923047_ChIP-ChIP_STHdh_Human1.35600235
53GATA3_27048872_Chip-Seq_THYMUS_Human1.35556957
54* FOXA2_19822575_ChIP-Seq_HepG2_Human1.34983469
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33800509
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29077163
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27654938
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27405862
59GATA3_26560356_Chip-Seq_TH2_Human1.27135557
60* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26529400
61* IRF8_27001747_Chip-Seq_BMDM_Mouse1.25747291
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21711204
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19169667
64* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18754662
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18050733
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15950811
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14539571
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13355003
69* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13276157
70UTX_26944678_Chip-Seq_JUKART_Human1.13193489
71* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12768587
72* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12768587
73TCF7_22412390_ChIP-Seq_EML_Mouse1.10713918
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08841940
75GATA1_19941826_ChIP-Seq_K562_Human1.06287719
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.04886091
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02153996
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01163306
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00680071
80KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99679873
81* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94357185
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94287864
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91756428
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88975816
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87861754
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85920929
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80612326
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80485769
89SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79804562
90* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79579808
91GATA4_25053715_ChIP-Seq_YYC3_Human0.79075498
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76037321
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74604117
94MAF_26560356_Chip-Seq_TH2_Human0.74134762
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73423948
96* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73270716
97KDM2B_26808549_Chip-Seq_DND41_Human0.73161602
98SMRT_27268052_Chip-Seq_Bcells_Human0.72939151
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72817636
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72609095
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.72581426
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71416145
103EGR1_19032775_ChIP-ChIP_M12_Human0.69688771
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67603931
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.67493554
106SOX2_20726797_ChIP-Seq_SW620_Human0.66661914
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66306577
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65882378
109PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.64214806
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63826061
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.63789038
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.63071539
113VDR_24787735_ChIP-Seq_THP-1_Human0.62736095
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62121674
115BRD4_27068464_Chip-Seq_AML-cells_Mouse0.61100733
116* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60631342
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60429230
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.58308257
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.57995916
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.57267227
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.56854307
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.56582644
123AR_20517297_ChIP-Seq_VCAP_Human0.55215965
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.54787289
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54587031
126CEBPB_22108803_ChIP-Seq_LS180_Human0.54017050
127STAT1_17558387_ChIP-Seq_HELA_Human0.53614280
128CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.53075183
129BCAT_22108803_ChIP-Seq_LS180_Human0.52218572
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.52049750
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51884609
132CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.51540475
133CJUN_26792858_Chip-Seq_BT549_Human0.50479025
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.50416156
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.49503548
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.47758878
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.47546518
138MYC_19915707_ChIP-ChIP_AK7_Human0.47354122
139GATA2_19941826_ChIP-Seq_K562_Human0.46533179
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46500410
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46287299
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.46093210
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.45768415
144* FOXA1_25552417_ChIP-Seq_VCAP_Human0.45582630
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44630408
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.44497606
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44072541
148FOXH1_21741376_ChIP-Seq_EPCs_Human0.43570312
149ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.43556241
150TAF2_19829295_ChIP-Seq_ESCs_Human0.43405155
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.43077337
152SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.43016626
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.42734553
154STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.42392520
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.41786557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.58758959
2MP0005360_urolithiasis6.90454849
3MP0005085_abnormal_gallbladder_physiolo5.72739261
4MP0005365_abnormal_bile_salt5.54957665
5MP0008875_abnormal_xenobiotic_pharmacok4.56727082
6MP0003806_abnormal_nucleotide_metabolis3.70397156
7MP0003252_abnormal_bile_duct3.53311795
8MP0010329_abnormal_lipoprotein_level3.39994281
9MP0009840_abnormal_foam_cell3.24452254
10MP0003195_calcinosis2.90072963
11MP0005083_abnormal_biliary_tract2.77649222
12MP0003191_abnormal_cellular_cholesterol2.69319694
13MP0005332_abnormal_amino_acid2.62837820
14MP0001666_abnormal_nutrient_absorption2.28552492
15MP0001800_abnormal_humoral_immune2.20252345
16MP0003300_gastrointestinal_ulcer2.12079223
17MP0000609_abnormal_liver_physiology2.08294838
18MP0003828_pulmonary_edema2.08166840
19MP0004019_abnormal_vitamin_homeostasis2.05765854
20MP0002138_abnormal_hepatobiliary_system2.03036180
21MP0003172_abnormal_lysosome_physiology2.01121854
22MP0005671_abnormal_response_to2.00639590
23MP0002723_abnormal_immune_serum1.99502989
24MP0002452_abnormal_antigen_presenting1.98508020
25MP0002118_abnormal_lipid_homeostasis1.98419522
26MP0002420_abnormal_adaptive_immunity1.82636618
27MP0005319_abnormal_enzyme/_coenzyme1.82361287
28MP0001819_abnormal_immune_cell1.80733622
29MP0003186_abnormal_redox_activity1.68486934
30MP0005397_hematopoietic_system_phenotyp1.61704496
31MP0001545_abnormal_hematopoietic_system1.61704496
32MP0005584_abnormal_enzyme/coenzyme_acti1.58219026
33MP0009697_abnormal_copulation1.57480644
34MP0002405_respiratory_system_inflammati1.57441386
35MP0001764_abnormal_homeostasis1.56614433
36MP0009764_decreased_sensitivity_to1.56554335
37MP0002132_abnormal_respiratory_system1.52393467
38MP0010155_abnormal_intestine_physiology1.52011563
39MP0003868_abnormal_feces_composition1.50268595
40MP0008004_abnormal_stomach_pH1.46464924
41MP0009278_abnormal_bone_marrow1.46331168
42MP0008260_abnormal_autophagy1.42656477
43MP0003724_increased_susceptibility_to1.41551313
44MP0003011_delayed_dark_adaptation1.40288662
45MP0003705_abnormal_hypodermis_morpholog1.39419444
46MP0002998_abnormal_bone_remodeling1.37921018
47MP0003436_decreased_susceptibility_to1.37675198
48MP0005451_abnormal_body_composition1.37386195
49MP0001851_eye_inflammation1.32032008
50MP0000716_abnormal_immune_system1.31512994
51MP0000604_amyloidosis1.30229078
52MP0002166_altered_tumor_susceptibility1.29438179
53MP0000465_gastrointestinal_hemorrhage1.28399596
54MP0008469_abnormal_protein_level1.24291998
55MP0004947_skin_inflammation1.23613876
56MP0003656_abnormal_erythrocyte_physiolo1.23387870
57MP0009643_abnormal_urine_homeostasis1.22333749
58MP0000858_altered_metastatic_potential1.21453136
59MP0002398_abnormal_bone_marrow1.21148094
60MP0002254_reproductive_system_inflammat1.21038600
61MP0009763_increased_sensitivity_to1.19550846
62MP0003183_abnormal_peptide_metabolism1.19069145
63MP0000689_abnormal_spleen_morphology1.14749207
64MP0000598_abnormal_liver_morphology1.13639403
65MP0008438_abnormal_cutaneous_collagen1.08701740
66MP0010368_abnormal_lymphatic_system1.07247869
67MP0000569_abnormal_digit_pigmentation1.07031262
68MP0003690_abnormal_glial_cell1.06998112
69MP0003763_abnormal_thymus_physiology1.06738001
70MP0002722_abnormal_immune_system1.04532901
71MP0006082_CNS_inflammation1.04500907
72MP0009785_altered_susceptibility_to1.02791309
73MP0003866_abnormal_defecation1.00223359
74MP0005647_abnormal_sex_gland1.00163722
75MP0002429_abnormal_blood_cell0.99618981
76MP0001835_abnormal_antigen_presentation0.98959109
77MP0002876_abnormal_thyroid_physiology0.98536369
78MP0003075_altered_response_to0.97538683
79MP0005464_abnormal_platelet_physiology0.94674707
80MP0009333_abnormal_splenocyte_physiolog0.93597574
81MP0003448_altered_tumor_morphology0.93313331
82MP0001958_emphysema0.91910412
83MP0005670_abnormal_white_adipose0.91627184
84MP0006054_spinal_hemorrhage0.90808296
85MP0002419_abnormal_innate_immunity0.90391581
86MP0004510_myositis0.88254871
87MP0009642_abnormal_blood_homeostasis0.88115291
88MP0002396_abnormal_hematopoietic_system0.86328263
89MP0005636_abnormal_mineral_homeostasis0.86029666
90MP0005058_abnormal_lysosome_morphology0.85871424
91MP0004130_abnormal_muscle_cell0.85025907
92MP0005084_abnormal_gallbladder_morpholo0.84479322
93MP0005408_hypopigmentation0.83434726
94MP0005390_skeleton_phenotype0.82966578
95MP0005535_abnormal_body_temperature0.82485545
96MP0005376_homeostasis/metabolism_phenot0.82272389
97MP0005310_abnormal_salivary_gland0.80588772
98MP0002009_preneoplasia0.79588630
99MP0002971_abnormal_brown_adipose0.78907697
100MP0002006_tumorigenesis0.78604948
101MP0005166_decreased_susceptibility_to0.75836044
102MP0005025_abnormal_response_to0.74954563
103MP0005334_abnormal_fat_pad0.74601925
104MP0009765_abnormal_xenobiotic_induced0.74468906
105MP0005164_abnormal_response_to0.74016577
106MP0004782_abnormal_surfactant_physiolog0.73939371
107MP0001853_heart_inflammation0.73561013
108MP0001663_abnormal_digestive_system0.71737739
109MP0002277_abnormal_respiratory_mucosa0.71485387
110MP0001845_abnormal_inflammatory_respons0.71058918
111MP0001533_abnormal_skeleton_physiology0.69942574
112MP0002078_abnormal_glucose_homeostasis0.67328332
113MP0002332_abnormal_exercise_endurance0.67049875
114MP0004883_abnormal_blood_vessel0.65733127
115MP0001756_abnormal_urination0.64848844
116MP0005167_abnormal_blood-brain_barrier0.63054863
117MP0002136_abnormal_kidney_physiology0.62594359
118MP0005275_abnormal_skin_tensile0.61111754
119MP0002148_abnormal_hypersensitivity_rea0.61004785
120MP0006036_abnormal_mitochondrial_physio0.60568693
121MP0001661_extended_life_span0.60486281
122MP0000249_abnormal_blood_vessel0.59807385
123MP0005448_abnormal_energy_balance0.56298601
124MP0002295_abnormal_pulmonary_circulatio0.55485530
125MP0009053_abnormal_anal_canal0.53603657
126MP0005220_abnormal_exocrine_pancreas0.50813626
127MP0009115_abnormal_fat_cell0.50494884
128MP0008873_increased_physiological_sensi0.49508999
129MP0005248_abnormal_Harderian_gland0.48981223
130MP0005266_abnormal_metabolism0.48548191
131MP0000685_abnormal_immune_system0.48367079
132MP0003329_amyloid_beta_deposits0.48207937
133MP0005387_immune_system_phenotype0.48195591
134MP0001790_abnormal_immune_system0.48195591
135MP0003638_abnormal_response/metabolism_0.47384045
136MP0000343_altered_response_to0.46984054
137MP0005395_other_phenotype0.46955390
138MP0005000_abnormal_immune_tolerance0.45959591
139MP0000639_abnormal_adrenal_gland0.44790554
140MP0002168_other_aberrant_phenotype0.43854203
141MP0001243_abnormal_dermal_layer0.43436479
142MP0003303_peritoneal_inflammation0.41576471
143MP0008874_decreased_physiological_sensi0.40443497
144MP0002090_abnormal_vision0.39891814
145MP0005666_abnormal_adipose_tissue0.39074647

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.90033696
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.55683723
3Intrahepatic cholestasis (HP:0001406)6.49435592
4Prolonged partial thromboplastin time (HP:0003645)6.39302089
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.10358351
6Xanthomatosis (HP:0000991)5.95642682
7Complement deficiency (HP:0004431)5.68796543
8Hypobetalipoproteinemia (HP:0003563)5.67459317
9Hyperlipoproteinemia (HP:0010980)5.20140451
10Joint hemorrhage (HP:0005261)5.12423799
11Recurrent abscess formation (HP:0002722)5.06917532
12Myositis (HP:0100614)4.87171113
13Orchitis (HP:0100796)4.71580626
14Retrobulbar optic neuritis (HP:0100654)4.49044764
15Optic neuritis (HP:0100653)4.49044764
16Hypolipoproteinemia (HP:0010981)4.45745359
17Abnormality of the common coagulation pathway (HP:0010990)4.42481016
18Abnormality of complement system (HP:0005339)4.35956622
19Abnormality of macrophages (HP:0004311)4.35053459
20Epidermoid cyst (HP:0200040)4.22484030
21Hyperammonemia (HP:0001987)4.21848003
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12948902
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.12393860
24Hypoalphalipoproteinemia (HP:0003233)4.10316046
25Systemic lupus erythematosus (HP:0002725)3.94144116
26Elevated erythrocyte sedimentation rate (HP:0003565)3.93276999
27Abnormality of methionine metabolism (HP:0010901)3.88942849
28Recurrent gram-negative bacterial infections (HP:0005420)3.88107166
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.85766262
30Fat malabsorption (HP:0002630)3.85611979
31Hyperglycinemia (HP:0002154)3.83719151
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.78826782
33Ketosis (HP:0001946)3.77865521
34Abnormality of pyrimidine metabolism (HP:0004353)3.64130382
35Abnormality of the intrinsic pathway (HP:0010989)3.58883415
36Hyperglycinuria (HP:0003108)3.57862507
37Stomatitis (HP:0010280)3.55255286
38Hypercholesterolemia (HP:0003124)3.49423356
39Hypoglycemic coma (HP:0001325)3.47550136
40Abnormality of serine family amino acid metabolism (HP:0010894)3.47492914
41Abnormality of glycine metabolism (HP:0010895)3.47492914
42Myocardial infarction (HP:0001658)3.43857679
43Recurrent skin infections (HP:0001581)3.43384900
44Spontaneous hematomas (HP:0007420)3.43095621
45Gastrointestinal infarctions (HP:0005244)3.41939099
46Conjugated hyperbilirubinemia (HP:0002908)3.40632753
47Keratoconjunctivitis sicca (HP:0001097)3.38962427
48Glomerulonephritis (HP:0000099)3.34459553
49Chronic obstructive pulmonary disease (HP:0006510)3.32249053
50Obstructive lung disease (HP:0006536)3.32249053
51Meningitis (HP:0001287)3.24138986
52Abnormality of glycolipid metabolism (HP:0010969)3.22174684
53Abnormality of liposaccharide metabolism (HP:0010968)3.22174684
54Abnormality of glycosphingolipid metabolism (HP:0004343)3.22174684
55Epistaxis (HP:0000421)3.20273398
56Recurrent fungal infections (HP:0002841)3.18682761
57Mediastinal lymphadenopathy (HP:0100721)3.18170990
58Gingivitis (HP:0000230)3.16685666
59Abnormality of fatty-acid metabolism (HP:0004359)3.14209669
60Prolonged bleeding time (HP:0003010)3.10888618
61Keratoconjunctivitis (HP:0001096)3.10017037
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.09501656
63Hemoptysis (HP:0002105)3.06304816
64Steatorrhea (HP:0002570)3.04442819
65Pulmonary infiltrates (HP:0002113)3.00213408
66Spontaneous abortion (HP:0005268)2.98405820
67Hyperbilirubinemia (HP:0002904)2.97347726
68Vasculitis (HP:0002633)2.97306561
69Arterial thrombosis (HP:0004420)2.93623671
70Abnormality of nucleobase metabolism (HP:0010932)2.92768423
71Recurrent cutaneous fungal infections (HP:0011370)2.91937344
72Chronic mucocutaneous candidiasis (HP:0002728)2.91937344
73Amyloidosis (HP:0011034)2.89630835
74Purpura (HP:0000979)2.84859796
75Hepatocellular carcinoma (HP:0001402)2.84795238
76Peritonitis (HP:0002586)2.83839973
77Vascular calcification (HP:0004934)2.78958218
78Encephalitis (HP:0002383)2.77388812
79Increased cerebral lipofuscin (HP:0011813)2.76771703
80Urticaria (HP:0001025)2.75518122
81Skin nodule (HP:0200036)2.75242577
82Gangrene (HP:0100758)2.73494165
83Abnormality of serum amino acid levels (HP:0003112)2.71851774
84Delayed CNS myelination (HP:0002188)2.70323001
85Ketoacidosis (HP:0001993)2.70135310
86Chest pain (HP:0100749)2.69265439
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.68992479
88Dysostosis multiplex (HP:0000943)2.61352260
89Mitral stenosis (HP:0001718)2.60780278
90Abnormality of purine metabolism (HP:0004352)2.57087443
91Cardiovascular calcification (HP:0011915)2.55500478
92Metabolic acidosis (HP:0001942)2.53937544
93Gingival bleeding (HP:0000225)2.53796703
94Episodic fever (HP:0001954)2.40193097
95Anorexia (HP:0002039)2.38625384
96Hypochromic microcytic anemia (HP:0004840)2.38159976
97Nephritis (HP:0000123)2.37745205
98Abnormality of the pleura (HP:0002103)2.36229126
99Loss of speech (HP:0002371)2.35417185
100Esophageal varix (HP:0002040)2.34905152
101Leukocytosis (HP:0001974)2.33421536
102Lethargy (HP:0001254)2.31344839
103Sensorimotor neuropathy (HP:0007141)2.30753892
104Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30584965
105Abnormality of polysaccharide metabolism (HP:0011012)2.30584965
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30584965
107Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30105463
108Dicarboxylic aciduria (HP:0003215)2.30105463
109Menorrhagia (HP:0000132)2.29146174
110Urinary glycosaminoglycan excretion (HP:0003541)2.28782997
111Mucopolysacchariduria (HP:0008155)2.28782997
112Vacuolated lymphocytes (HP:0001922)2.26975849
113Increased neuronal autofluorescent lipopigment (HP:0002074)2.26924494
114Thrombophlebitis (HP:0004418)2.26824257
115Increased serum ferritin (HP:0003281)2.26416235
116Pancreatitis (HP:0001733)2.24791601
117Hemorrhage of the eye (HP:0011885)2.21466414
118T lymphocytopenia (HP:0005403)2.20221334
119Spastic diplegia (HP:0001264)2.19761354
120Hypoglycemic seizures (HP:0002173)2.19226493
121Abnormal gallbladder morphology (HP:0012437)2.17094701
122Interstitial pulmonary disease (HP:0006530)2.16528125
123Abnormality of T cell number (HP:0011839)2.16012677
124Cellulitis (HP:0100658)2.15907828
125Abnormality of proline metabolism (HP:0010907)2.15313841
126Hydroxyprolinuria (HP:0003080)2.15313841
127Polycythemia (HP:0001901)2.15245320
128Cerebral edema (HP:0002181)2.13535924
129Recurrent viral infections (HP:0004429)2.13173274
130Cholelithiasis (HP:0001081)2.11286085
131Irritability (HP:0000737)2.10488196
132Increased IgE level (HP:0003212)2.10154791
133Acanthocytosis (HP:0001927)2.07499225
134Axonal loss (HP:0003447)2.06901403
135Periodontitis (HP:0000704)2.06475693
136Vertigo (HP:0002321)2.05885802
137Abnormal platelet volume (HP:0011876)2.05795833
138Polyneuropathy (HP:0001271)2.04958658
139Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04717203
140Petechiae (HP:0000967)2.03501782
141Generalized aminoaciduria (HP:0002909)2.01657061
142Glomerulopathy (HP:0100820)2.01404714
143Inflammation of the large intestine (HP:0002037)2.01256524
144Abnormality of the peritoneum (HP:0002585)2.00591291
145Abnormality of iron homeostasis (HP:0011031)2.00440495
146Acne (HP:0001061)1.99845774
147Osteomyelitis (HP:0002754)1.99563013
148Abnormal gallbladder physiology (HP:0012438)1.99372899
149Cholecystitis (HP:0001082)1.99372899
150Nausea (HP:0002018)1.99289321
151Neonatal onset (HP:0003623)1.98838659
152Enlarged kidneys (HP:0000105)1.96872367
153Vomiting (HP:0002013)1.96809862
154Gout (HP:0001997)1.95857415
155Hypophosphatemic rickets (HP:0004912)1.95366190
156Malnutrition (HP:0004395)1.93485461
157Hematochezia (HP:0002573)1.92675546
158Pulmonary embolism (HP:0002204)1.92404422
159Abnormality of transition element cation homeostasis (HP:0011030)1.92006343
160Opisthotonus (HP:0002179)1.91594309
161Disinhibition (HP:0000734)1.90552822
162Thrombocytosis (HP:0001894)1.90036190
163Abnormal cartilage morphology (HP:0002763)1.87927053
164Rickets (HP:0002748)1.84355670
165Hypertriglyceridemia (HP:0002155)1.80936832
166Alkalosis (HP:0001948)1.80236553
167Eczematoid dermatitis (HP:0000976)1.78841776
168Abnormality of the gallbladder (HP:0005264)1.77777764
169Upper motor neuron abnormality (HP:0002127)1.77421875
170Abnormal enzyme/coenzyme activity (HP:0012379)1.77106960
171Elevated hepatic transaminases (HP:0002910)1.76515653
172Joint swelling (HP:0001386)1.75229308
173Recurrent bacterial skin infections (HP:0005406)1.74688446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.33832428
2ERN14.43339933
3FGFR43.55099675
4SIK13.46506932
5MAP3K142.96503788
6FES2.61307811
7INSRR2.61273094
8TYK22.42806036
9MST1R2.36312242
10ERBB42.31667539
11TAOK32.25786184
12TBK12.13636343
13BLK2.11784146
14PBK2.11009915
15PRPF4B2.01992503
16ABL21.91159121
17IRAK31.84522042
18TNK21.67796379
19NEK91.63941783
20BTK1.62553451
21JAK11.58291452
22RIPK41.57636664
23PIK3CG1.56639644
24TRIB31.51596087
25TEC1.46087128
26MAP2K41.43002495
27FLT31.41502621
28PKN21.39370723
29IKBKE1.38796340
30FGR1.37644569
31JAK21.35939527
32DAPK21.35776856
33MAPK111.35681321
34TGFBR21.35364508
35CSK1.24391282
36TAOK11.23802279
37KDR1.20200034
38MATK1.20071139
39YES11.19520767
40MAP3K31.13375359
41IKBKB1.10986309
42MAP3K61.09685917
43ITK1.09358200
44FRK1.08442370
45EPHA31.08419672
46LCK1.08023132
47MAP2K31.05197035
48PTK61.04425294
49MAP3K21.02685397
50BMPR20.93843358
51CSF1R0.91575158
52LATS10.90874316
53MAP3K130.89991727
54CAMKK20.88507350
55JAK30.88239040
56EPHB10.86180387
57PRKAA20.85218123
58CAMK1D0.84417852
59IRAK40.84341755
60STK38L0.84082157
61MAP3K110.82059759
62MAPK40.81881684
63TIE10.80068661
64KIT0.79517600
65TRPM70.78687162
66TAOK20.76114811
67MAPK120.75519456
68KSR20.75364935
69MARK30.74819897
70IRAK10.73754601
71MET0.73070641
72PINK10.72647995
73PRKCZ0.70544113
74FGFR30.70204026
75CDC42BPA0.69820241
76MARK20.69223599
77BMX0.69022981
78STK30.68856536
79EPHB20.66323384
80CHUK0.64999160
81ACVR1B0.64508897
82RIPK10.64474057
83ERBB20.62602790
84SGK20.62107080
85CDK60.61859189
86PRKACG0.61714192
87GRK60.61528509
88MAP3K50.58630757
89GSK3A0.58032717
90IGF1R0.57982793
91ZAP700.56775651
92MAP4K10.56648796
93LRRK20.56314204
94LYN0.56246256
95NLK0.56235794
96MAPK70.55802130
97PRKCQ0.55397485
98FYN0.54818681
99TXK0.53074447
100PDPK10.52197875
101MAP3K70.51605756
102HIPK20.50942825
103STK100.48937793
104MOS0.48744936
105EGFR0.48681329
106NME20.48358226
107PIK3CA0.47743716
108ABL10.47567243
109PTK2B0.47056838
110MAP2K60.46202265
111PRKCD0.46090427
112MAP3K100.46038553
113RPS6KC10.45380161
114RPS6KL10.45380161
115CAMK2G0.44959852
116PIM20.43756793
117DYRK1B0.43430365
118RET0.42863101
119PDGFRB0.41865881
120HCK0.41761201
121SGK30.41293275
122GRK70.41250502
123PRKD20.40981325
124MAP2K10.40342508
125RPS6KA60.39927997
126STK110.38493298
127FGFR20.37895031
128IRAK20.37391604
129MYLK0.36444913
130MAPKAPK20.36421073
131PRKD10.36130022
132GRK10.35614484
133PIM10.35518447
134NUAK10.33831004
135PDK20.33646398
136SYK0.32953333
137MAPK150.32903559
138EIF2AK20.31710398
139PDK10.30037722
140MAP3K10.29474156

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.47731196
2Nitrogen metabolism_Homo sapiens_hsa009103.38754243
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32709434
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31658253
5Complement and coagulation cascades_Homo sapiens_hsa046103.08294102
6Arginine biosynthesis_Homo sapiens_hsa002202.98797027
7Tryptophan metabolism_Homo sapiens_hsa003802.60750512
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55697139
9Staphylococcus aureus infection_Homo sapiens_hsa051502.52183124
10Fatty acid degradation_Homo sapiens_hsa000712.45064537
11Asthma_Homo sapiens_hsa053102.43251228
12Osteoclast differentiation_Homo sapiens_hsa043802.42635207
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41657243
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40987828
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33160550
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30584625
17Autoimmune thyroid disease_Homo sapiens_hsa053202.15114607
18Peroxisome_Homo sapiens_hsa041462.14623151
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14459341
20PPAR signaling pathway_Homo sapiens_hsa033201.98205510
21Chemical carcinogenesis_Homo sapiens_hsa052041.97860076
22Other glycan degradation_Homo sapiens_hsa005111.97155995
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95417149
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94268172
25Butanoate metabolism_Homo sapiens_hsa006501.91749096
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.90827385
27Histidine metabolism_Homo sapiens_hsa003401.86637081
28Propanoate metabolism_Homo sapiens_hsa006401.84571302
29Caffeine metabolism_Homo sapiens_hsa002321.80100329
30Fatty acid metabolism_Homo sapiens_hsa012121.77336021
31Type I diabetes mellitus_Homo sapiens_hsa049401.75984613
32beta-Alanine metabolism_Homo sapiens_hsa004101.71934728
33Retinol metabolism_Homo sapiens_hsa008301.66232557
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.65000604
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63944607
36Phenylalanine metabolism_Homo sapiens_hsa003601.58679176
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55481379
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50025238
39Hematopoietic cell lineage_Homo sapiens_hsa046401.46924121
40Antigen processing and presentation_Homo sapiens_hsa046121.46105070
41B cell receptor signaling pathway_Homo sapiens_hsa046621.44695397
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44435714
43Toxoplasmosis_Homo sapiens_hsa051451.41419054
44Bile secretion_Homo sapiens_hsa049761.37513908
45Tyrosine metabolism_Homo sapiens_hsa003501.37060534
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35798248
47Selenocompound metabolism_Homo sapiens_hsa004501.35322638
48Starch and sucrose metabolism_Homo sapiens_hsa005001.32996778
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30324309
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29815439
51Sulfur metabolism_Homo sapiens_hsa009201.28369493
52Steroid biosynthesis_Homo sapiens_hsa001001.25678167
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25229088
54Viral myocarditis_Homo sapiens_hsa054161.22258908
55Influenza A_Homo sapiens_hsa051641.22232498
56Fatty acid elongation_Homo sapiens_hsa000621.19359223
57Pyruvate metabolism_Homo sapiens_hsa006201.15923221
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14818845
59ABC transporters_Homo sapiens_hsa020101.12355669
60Fat digestion and absorption_Homo sapiens_hsa049751.11312239
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.10066394
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09031324
63Platelet activation_Homo sapiens_hsa046111.08859485
64Folate biosynthesis_Homo sapiens_hsa007901.07149158
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06731232
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03100252
67Chemokine signaling pathway_Homo sapiens_hsa040621.02617143
68Acute myeloid leukemia_Homo sapiens_hsa052211.02576056
69Jak-STAT signaling pathway_Homo sapiens_hsa046301.01651854
70TNF signaling pathway_Homo sapiens_hsa046681.00988314
71Measles_Homo sapiens_hsa051620.99757312
72Carbon metabolism_Homo sapiens_hsa012000.98601806
73Biosynthesis of amino acids_Homo sapiens_hsa012300.97844272
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94348313
75Vitamin digestion and absorption_Homo sapiens_hsa049770.91592369
76Arginine and proline metabolism_Homo sapiens_hsa003300.90580720
77Herpes simplex infection_Homo sapiens_hsa051680.84936460
78T cell receptor signaling pathway_Homo sapiens_hsa046600.81232049
79Sulfur relay system_Homo sapiens_hsa041220.78256269
80Salmonella infection_Homo sapiens_hsa051320.77894066
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.76409833
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75201603
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.70081595
84Glutathione metabolism_Homo sapiens_hsa004800.69639586
85Primary immunodeficiency_Homo sapiens_hsa053400.69155114
86Glycerolipid metabolism_Homo sapiens_hsa005610.66713095
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.65176937
88Fatty acid biosynthesis_Homo sapiens_hsa000610.64372252
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64110601
90Lysine degradation_Homo sapiens_hsa003100.61818955
91Hepatitis B_Homo sapiens_hsa051610.61683930
92Vitamin B6 metabolism_Homo sapiens_hsa007500.60991396
93Dorso-ventral axis formation_Homo sapiens_hsa043200.59460337
94Prion diseases_Homo sapiens_hsa050200.59272945
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57836126
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56868723
97Non-small cell lung cancer_Homo sapiens_hsa052230.55185580
98Pentose phosphate pathway_Homo sapiens_hsa000300.52809073
99One carbon pool by folate_Homo sapiens_hsa006700.52250978
100Prolactin signaling pathway_Homo sapiens_hsa049170.51443106
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51268057
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50699339
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49905642
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49479468
105Pancreatic cancer_Homo sapiens_hsa052120.43111325
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.41368522
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39796045
108Metabolic pathways_Homo sapiens_hsa011000.39489561
109Shigellosis_Homo sapiens_hsa051310.39198348
110Renal cell carcinoma_Homo sapiens_hsa052110.36246101
111Chronic myeloid leukemia_Homo sapiens_hsa052200.36153104
112Apoptosis_Homo sapiens_hsa042100.35059235
113Systemic lupus erythematosus_Homo sapiens_hsa053220.35035631
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34630101
115FoxO signaling pathway_Homo sapiens_hsa040680.34495112
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.34245873
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34043673
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28252641
119Galactose metabolism_Homo sapiens_hsa000520.26626012
120African trypanosomiasis_Homo sapiens_hsa051430.26576919
121Malaria_Homo sapiens_hsa051440.24637634
122Insulin resistance_Homo sapiens_hsa049310.24602817
123Pertussis_Homo sapiens_hsa051330.22487956
124Fructose and mannose metabolism_Homo sapiens_hsa000510.20842161
125Legionellosis_Homo sapiens_hsa051340.20494764
126Graft-versus-host disease_Homo sapiens_hsa053320.17113118
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16535656
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.13000757
129Linoleic acid metabolism_Homo sapiens_hsa005910.11740798
130Lysosome_Homo sapiens_hsa041420.10690379
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.09599121
132Leishmaniasis_Homo sapiens_hsa051400.09278475
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06499496
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.05108503
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.04961544
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00964462
137Allograft rejection_Homo sapiens_hsa05330-0.0664697
138Renin-angiotensin system_Homo sapiens_hsa04614-0.0655836
139Hepatitis C_Homo sapiens_hsa05160-0.0427615
140Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0384100
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0364871
142Rheumatoid arthritis_Homo sapiens_hsa05323-0.0297457
143Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0277153
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0273644
145NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0255984
146Tuberculosis_Homo sapiens_hsa05152-0.0252254
147Amoebiasis_Homo sapiens_hsa05146-0.0134153
148Phagosome_Homo sapiens_hsa04145-0.0004668

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