CD300LG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to dietary excess (GO:0002021)5.45969168
2glycerolipid catabolic process (GO:0046503)5.36166581
3regulation of sequestering of triglyceride (GO:0010889)5.20074735
4fatty acid transmembrane transport (GO:1902001)5.01520094
5positive regulation of glomerulus development (GO:0090193)4.93375012
6vascular endothelial growth factor signaling pathway (GO:0038084)4.86295417
7lymph vessel development (GO:0001945)4.82845723
8negative regulation of amino acid transport (GO:0051956)4.58937811
9retina vasculature morphogenesis in camera-type eye (GO:0061299)4.48951809
10lipid particle organization (GO:0034389)4.48334366
11carnitine shuttle (GO:0006853)4.45497491
12lipid storage (GO:0019915)4.44402420
13protein heterotrimerization (GO:0070208)4.28678105
14positive regulation of glycolytic process (GO:0045821)4.27853788
15regulation of gonadotropin secretion (GO:0032276)4.26129942
16fatty acid homeostasis (GO:0055089)4.17362655
17low-density lipoprotein particle clearance (GO:0034383)4.08944967
18diacylglycerol metabolic process (GO:0046339)4.07456394
19regulation of lipoprotein metabolic process (GO:0050746)3.99913031
20negative regulation of response to food (GO:0032096)3.95472585
21negative regulation of appetite (GO:0032099)3.95472585
22regulation of glycogen (starch) synthase activity (GO:2000465)3.90381700
23negative regulation of macrophage differentiation (GO:0045650)3.86225163
24ethanol oxidation (GO:0006069)3.79169948
25negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.79031229
26tyrosine phosphorylation of STAT protein (GO:0007260)3.75141421
27* transcytosis (GO:0045056)3.73969308
28glycerol metabolic process (GO:0006071)3.66927746
29biotin metabolic process (GO:0006768)3.65471230
30fatty acid beta-oxidation (GO:0006635)3.62937942
31cardiac myofibril assembly (GO:0055003)3.60084189
32sarcomere organization (GO:0045214)3.58078473
33cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.57475938
34negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.57038954
35regulation of macrophage derived foam cell differentiation (GO:0010743)3.55909221
36adult feeding behavior (GO:0008343)3.54282711
37glomerular filtration (GO:0003094)3.53405259
38cellular response to leptin stimulus (GO:0044320)3.51407352
39endothelium development (GO:0003158)3.51344536
40regulation of cAMP-dependent protein kinase activity (GO:2000479)3.45537160
41carnitine transmembrane transport (GO:1902603)3.42066563
42brown fat cell differentiation (GO:0050873)3.41108762
43surfactant homeostasis (GO:0043129)3.36102519
44myofibril assembly (GO:0030239)3.35279094
45positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.33279272
46negative regulation of granulocyte differentiation (GO:0030853)3.33114000
47heart trabecula formation (GO:0060347)3.32771515
48response to phenylpropanoid (GO:0080184)3.28913192
49bundle of His cell to Purkinje myocyte communication (GO:0086069)3.27120805
50plasma membrane repair (GO:0001778)3.26315235
51positive regulation of fatty acid oxidation (GO:0046321)3.25269517
52fatty acid oxidation (GO:0019395)3.24491605
53oxaloacetate metabolic process (GO:0006107)3.22801651
54regulation of glomerulus development (GO:0090192)3.22384826
55negative regulation of DNA biosynthetic process (GO:2000279)3.21976129
56carnitine transport (GO:0015879)3.21610511
57amino-acid betaine transport (GO:0015838)3.21610511
58regulation of cholesterol storage (GO:0010885)3.19246358
59lipid oxidation (GO:0034440)3.18424847
60renal filtration (GO:0097205)3.16898202
61response to vitamin E (GO:0033197)3.15952000
62regulation of actin filament-based movement (GO:1903115)3.15397066
63detection of calcium ion (GO:0005513)3.14879006
64negative regulation of metanephros development (GO:0072217)3.14619286
65response to epinephrine (GO:0071871)3.11673229
66tricarboxylic acid cycle (GO:0006099)3.11572869
67fatty acid catabolic process (GO:0009062)3.11248994
68alditol metabolic process (GO:0019400)3.09762433
69negative regulation of phagocytosis (GO:0050765)3.08287931
70response to leptin (GO:0044321)3.08264316
71CDP-diacylglycerol biosynthetic process (GO:0016024)3.07722784
72regulation of fatty acid oxidation (GO:0046320)3.07709069
73regulation of lipid storage (GO:0010883)3.05671474
74positive regulation of lipoprotein lipase activity (GO:0051006)3.05154587
75positive regulation of triglyceride lipase activity (GO:0061365)3.05154587
76phosphatidic acid biosynthetic process (GO:0006654)3.05153979
77phosphatidic acid metabolic process (GO:0046473)3.05153979
78negative regulation of Rho protein signal transduction (GO:0035024)3.04422488
79negative regulation of gluconeogenesis (GO:0045721)3.03321726
80negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.03292221
81response to nitrosative stress (GO:0051409)3.01919939
82primary alcohol metabolic process (GO:0034308)3.00009486
83ovulation from ovarian follicle (GO:0001542)2.99927249
84lymphangiogenesis (GO:0001946)2.98748913
85negative regulation of nitric-oxide synthase activity (GO:0051001)2.97863082
86regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.97125477
87triglyceride catabolic process (GO:0019433)2.95893789
88positive regulation of lipid storage (GO:0010884)2.94040577
89polyol transport (GO:0015791)2.93837575
90chemical homeostasis within a tissue (GO:0048875)2.93321287
912-oxoglutarate metabolic process (GO:0006103)2.90048473
92somite development (GO:0061053)2.89130395
93acetyl-CoA metabolic process (GO:0006084)2.88328099
94regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.87310650
95retinol metabolic process (GO:0042572)2.87021534
96ethanol metabolic process (GO:0006067)2.86877016
97regulation of protein kinase A signaling (GO:0010738)2.85952366
98positive regulation of fatty acid beta-oxidation (GO:0032000)2.85756595
99regulation of triglyceride catabolic process (GO:0010896)2.85704313
100succinate metabolic process (GO:0006105)2.85319554
101regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.84868816
102angiogenesis involved in wound healing (GO:0060055)2.82027310
103regulation of receptor binding (GO:1900120)2.81873249
104triglyceride biosynthetic process (GO:0019432)2.81788530
105negative regulation of execution phase of apoptosis (GO:1900118)2.81295751
106vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.81030896
107triglyceride metabolic process (GO:0006641)2.80177779
108branched-chain amino acid catabolic process (GO:0009083)2.79152068
109glomerular basement membrane development (GO:0032836)2.78827663
110glomerular visceral epithelial cell development (GO:0072015)2.77650779
111negative regulation of protein autophosphorylation (GO:0031953)2.76729981
112cGMP-mediated signaling (GO:0019934)2.76641871
113regulation of skeletal muscle contraction (GO:0014819)2.76238587
114acylglycerol biosynthetic process (GO:0046463)2.75978196
115neutral lipid biosynthetic process (GO:0046460)2.75978196
116muscle filament sliding (GO:0030049)2.74777958
117actin-myosin filament sliding (GO:0033275)2.74777958
118cell migration involved in sprouting angiogenesis (GO:0002042)2.74478206
119neutral lipid catabolic process (GO:0046461)2.72716299
120acylglycerol catabolic process (GO:0046464)2.72716299
121short-chain fatty acid metabolic process (GO:0046459)2.72686015
122venous blood vessel morphogenesis (GO:0048845)2.72349026
123CDP-diacylglycerol metabolic process (GO:0046341)2.71779892
124behavioral response to nicotine (GO:0035095)2.70438586
125negative regulation of lipid catabolic process (GO:0050995)2.70158419
126cellular response to vitamin (GO:0071295)2.67669353
127plasma lipoprotein particle clearance (GO:0034381)2.67542699
128regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.67296374
129lysine catabolic process (GO:0006554)2.67153992
130lysine metabolic process (GO:0006553)2.67153992
131regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.66718975
132cellular response to epinephrine stimulus (GO:0071872)2.66567340
133ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.65957368
134negative regulation of smooth muscle cell proliferation (GO:0048662)2.65810711
135positive regulation of vasculogenesis (GO:2001214)2.65310498
136regulation of acyl-CoA biosynthetic process (GO:0050812)2.65020533
137endocrine hormone secretion (GO:0060986)2.64585503
138cardiac muscle contraction (GO:0060048)2.64573666
139monocarboxylic acid catabolic process (GO:0072329)2.63850467
140regulation of relaxation of muscle (GO:1901077)2.63432390
141endothelial cell morphogenesis (GO:0001886)2.63203727
142branched-chain amino acid metabolic process (GO:0009081)2.62660178
143negative regulation of potassium ion transmembrane transport (GO:1901380)2.62550905
144cardiac muscle tissue morphogenesis (GO:0055008)2.62393497
145positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.61862862
146ventricular cardiac muscle cell action potential (GO:0086005)2.61594144
147white fat cell differentiation (GO:0050872)2.60459384
148valine metabolic process (GO:0006573)2.55580062
149blood vessel endothelial cell migration (GO:0043534)2.54813342
150cardiac muscle hypertrophy (GO:0003300)2.53733566
151regulation of endothelial cell differentiation (GO:0045601)2.53262184
152regulation of cardiac muscle cell contraction (GO:0086004)2.52485155
153quaternary ammonium group transport (GO:0015697)2.51680725
154intracellular lipid transport (GO:0032365)2.47813628
155regulation of sarcomere organization (GO:0060297)2.47407424
156creatine metabolic process (GO:0006600)2.47021480
157phagocytosis, recognition (GO:0006910)2.46796667
158actin-mediated cell contraction (GO:0070252)2.45466121
159long-chain fatty acid transport (GO:0015909)2.45400252
160regulation of p38MAPK cascade (GO:1900744)2.44858568
161NADH metabolic process (GO:0006734)2.44648304
162regulation of triglyceride biosynthetic process (GO:0010866)2.44341896
163adult heart development (GO:0007512)2.43717357
164regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.43623134
165fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.43301709
166carnitine metabolic process (GO:0009437)2.42794425
167negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.42627259
168acylglycerol homeostasis (GO:0055090)2.42530110
169triglyceride homeostasis (GO:0070328)2.42530110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.69995077
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.34307266
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.87876799
4IGF1R_20145208_ChIP-Seq_DFB_Human2.77242124
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.40967810
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38290166
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.35175363
8ZNF274_21170338_ChIP-Seq_K562_Hela2.34418926
9* RXR_22158963_ChIP-Seq_LIVER_Mouse2.19524300
10* LXR_22158963_ChIP-Seq_LIVER_Mouse2.15929543
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11135757
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.97897483
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90313829
14* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86914539
15GATA2_21666600_ChIP-Seq_HMVEC_Human1.86247731
16* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79136637
17CLOCK_20551151_ChIP-Seq_293T_Human1.75303242
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72016533
19EZH2_22144423_ChIP-Seq_EOC_Human1.71643056
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71594953
21TBX20_22328084_ChIP-Seq_HEART_Mouse1.71282728
22TBX20_22080862_ChIP-Seq_HEART_Mouse1.71282728
23GBX2_23144817_ChIP-Seq_PC3_Human1.64495006
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64131414
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62782779
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60476498
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60457011
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.58643732
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53598931
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52574464
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52091511
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52091511
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48882356
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.44603301
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43171754
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42404342
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40017958
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38903147
39P300_19829295_ChIP-Seq_ESCs_Human1.37693715
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.36999425
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.36115616
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32145097
43ER_23166858_ChIP-Seq_MCF-7_Human1.31283377
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29487381
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.28886559
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.27611249
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.26559439
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26559439
49GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.25983769
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.25047381
51AR_25329375_ChIP-Seq_VCAP_Human1.23596002
52CJUN_26792858_Chip-Seq_BT549_Human1.22671816
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22287687
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22284072
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22136271
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22075320
57DROSHA_22980978_ChIP-Seq_HELA_Human1.21701837
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.20739841
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.20732638
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20136543
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19810998
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.19330398
63TAF15_26573619_Chip-Seq_HEK293_Human1.18816285
64GATA1_22025678_ChIP-Seq_K562_Human1.18274673
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.16983908
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15257810
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14850426
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14706590
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13916456
70PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13054647
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11399458
72AHR_22903824_ChIP-Seq_MCF-7_Human1.11283171
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10878449
74CBP_20019798_ChIP-Seq_JUKART_Human1.10878449
75* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09893866
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.09059329
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08798498
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08561651
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06875892
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05915496
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05800567
82CBP_21632823_ChIP-Seq_H3396_Human1.05617770
83AR_20517297_ChIP-Seq_VCAP_Human1.05412702
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05158244
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05017136
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04667299
87TCF4_22108803_ChIP-Seq_LS180_Human1.04025893
88TCF4_23295773_ChIP-Seq_U87_Human1.03894302
89STAT3_23295773_ChIP-Seq_U87_Human1.03740825
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.03236291
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03104780
92AR_21572438_ChIP-Seq_LNCaP_Human1.02029120
93CDX2_22108803_ChIP-Seq_LS180_Human1.01730842
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00980172
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00846489
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00846489
97* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00731629
98FOXH1_21741376_ChIP-Seq_ESCs_Human1.00482858
99SOX2_19829295_ChIP-Seq_ESCs_Human1.00462588
100NANOG_19829295_ChIP-Seq_ESCs_Human1.00462588
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00342198
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00152917
103ERA_21632823_ChIP-Seq_H3396_Human1.00006974
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99773624
105TP63_17297297_ChIP-ChIP_HaCaT_Human0.99617876
106BCAT_22108803_ChIP-Seq_LS180_Human0.99039816
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98843225
108VDR_22108803_ChIP-Seq_LS180_Human0.97510306
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97064236
110TP53_18474530_ChIP-ChIP_U2OS_Human0.96536097
111FUS_26573619_Chip-Seq_HEK293_Human0.96493191
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96322838
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95759717
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.95739543
115TAF2_19829295_ChIP-Seq_ESCs_Human0.95275386
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95200569
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94874965
118RNF2_27304074_Chip-Seq_ESCs_Mouse0.94560630
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.94371595
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.92967924
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92930173
122NCOR_22424771_ChIP-Seq_293T_Human0.92268824
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.91797957
124EWS_26573619_Chip-Seq_HEK293_Human0.91772648
125PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91689825
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91433917
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.91286378
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.91214407
129ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91151555
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90947918
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90134158
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90107286
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90095324
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90016653
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.89993003
136WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89867104
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89599043
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.86750582
139VDR_24787735_ChIP-Seq_THP-1_Human0.86565817
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.86372444
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85051714
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84650152
143TP53_16413492_ChIP-PET_HCT116_Human0.83260591
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82155046
145FOXO3_23340844_ChIP-Seq_DLD1_Human0.81389459
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79402412
147GATA1_19941826_ChIP-Seq_K562_Human0.79178973
148SMAD4_21799915_ChIP-Seq_A2780_Human0.78656609
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.75839090
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75626765
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75576558
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74861605
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74762979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.57166336
2MP0002837_dystrophic_cardiac_calcinosis4.50068652
3MP0010368_abnormal_lymphatic_system3.81680999
4MP0004215_abnormal_myocardial_fiber3.55532599
5MP0004130_abnormal_muscle_cell3.52992424
6MP0004084_abnormal_cardiac_muscle3.50398740
7MP0000751_myopathy3.26924703
8MP0001879_abnormal_lymphatic_vessel3.24936309
9MP0003724_increased_susceptibility_to3.18860538
10MP0003646_muscle_fatigue2.84875634
11MP0005666_abnormal_adipose_tissue2.84151967
12MP0004036_abnormal_muscle_relaxation2.73961600
13MP0003828_pulmonary_edema2.68696794
14MP0002638_abnormal_pupillary_reflex2.55020160
15MP0003959_abnormal_lean_body2.41786173
16MP0004272_abnormal_basement_membrane2.41061554
17MP0004185_abnormal_adipocyte_glucose2.39240177
18MP0005330_cardiomyopathy2.36787525
19MP0003011_delayed_dark_adaptation2.29002176
20MP0006138_congestive_heart_failure2.19378221
21MP0008775_abnormal_heart_ventricle2.09186819
22MP0000749_muscle_degeneration2.08554077
23MP0005375_adipose_tissue_phenotype2.07048547
24MP0002972_abnormal_cardiac_muscle2.03090897
25MP0000013_abnormal_adipose_tissue2.02575114
26MP0005379_endocrine/exocrine_gland_phen2.00986510
27MP0000750_abnormal_muscle_regeneration1.99448980
28MP0005385_cardiovascular_system_phenoty1.97134082
29MP0001544_abnormal_cardiovascular_syste1.97134082
30MP0005620_abnormal_muscle_contractility1.94347905
31MP0002970_abnormal_white_adipose1.88708572
32MP0003186_abnormal_redox_activity1.86809593
33MP0004484_altered_response_of1.82096189
34MP0001501_abnormal_sleep_pattern1.80911813
35MP0005167_abnormal_blood-brain_barrier1.80230151
36MP0004087_abnormal_muscle_fiber1.79174798
37MP0005360_urolithiasis1.79008841
38MP0005503_abnormal_tendon_morphology1.73938613
39MP0006276_abnormal_autonomic_nervous1.72405166
40MP0005448_abnormal_energy_balance1.72009226
41MP0010329_abnormal_lipoprotein_level1.65632035
42MP0002332_abnormal_exercise_endurance1.63251191
43MP0000343_altered_response_to1.57652915
44MP0004085_abnormal_heartbeat1.55907901
45MP0010630_abnormal_cardiac_muscle1.55785098
46MP0002909_abnormal_adrenal_gland1.54865822
47MP0002971_abnormal_brown_adipose1.54050559
48MP0003950_abnormal_plasma_membrane1.49798852
49MP0005165_increased_susceptibility_to1.45441118
50MP0005085_abnormal_gallbladder_physiolo1.44379334
51MP0000003_abnormal_adipose_tissue1.43574352
52MP0003191_abnormal_cellular_cholesterol1.41378948
53MP0005365_abnormal_bile_salt1.40133833
54MP0005452_abnormal_adipose_tissue1.40003594
55MP0003137_abnormal_impulse_conducting1.37768478
56MP0002106_abnormal_muscle_physiology1.30221908
57MP0000230_abnormal_systemic_arterial1.28264432
58MP0004147_increased_porphyrin_level1.27682256
59MP0002118_abnormal_lipid_homeostasis1.24429861
60MP0002933_joint_inflammation1.21876924
61MP0002139_abnormal_hepatobiliary_system1.20053577
62MP0001661_extended_life_span1.19795966
63MP0001764_abnormal_homeostasis1.18748382
64MP0003868_abnormal_feces_composition1.18465173
65MP0000759_abnormal_skeletal_muscle1.16969152
66MP0002127_abnormal_cardiovascular_syste1.12162402
67MP0005595_abnormal_vascular_smooth1.12018831
68MP0003690_abnormal_glial_cell1.11996590
69MP0005369_muscle_phenotype1.09822786
70MP0003279_aneurysm1.05692853
71MP0008438_abnormal_cutaneous_collagen1.04702128
72MP0004145_abnormal_muscle_electrophysio1.03209807
73MP0009115_abnormal_fat_cell1.02665014
74MP0005334_abnormal_fat_pad1.02014876
75MP0000767_abnormal_smooth_muscle1.01422475
76MP0003252_abnormal_bile_duct1.00313325
77MP0005266_abnormal_metabolism0.99873267
78MP0005647_abnormal_sex_gland0.98321452
79MP0005551_abnormal_eye_electrophysiolog0.97322692
80MP0005535_abnormal_body_temperature0.95990792
81MP0002295_abnormal_pulmonary_circulatio0.94222218
82MP0002269_muscular_atrophy0.92953300
83MP0005332_abnormal_amino_acid0.90898621
84MP0000249_abnormal_blood_vessel0.89414964
85MP0008875_abnormal_xenobiotic_pharmacok0.88570477
86MP0004019_abnormal_vitamin_homeostasis0.88458122
87MP0006036_abnormal_mitochondrial_physio0.88366226
88MP0003195_calcinosis0.87968911
89MP0002128_abnormal_blood_circulation0.86787434
90MP0001984_abnormal_olfaction0.86157679
91MP0005319_abnormal_enzyme/_coenzyme0.84973812
92MP0000747_muscle_weakness0.84567820
93MP0005451_abnormal_body_composition0.84061393
94MP0003566_abnormal_cell_adhesion0.83351140
95MP0008004_abnormal_stomach_pH0.82105339
96MP0009643_abnormal_urine_homeostasis0.80327935
97MP0004510_myositis0.77683261
98MP0002876_abnormal_thyroid_physiology0.77161509
99MP0001851_eye_inflammation0.77141408
100MP0000609_abnormal_liver_physiology0.77073825
101MP0002108_abnormal_muscle_morphology0.75777946
102MP0003948_abnormal_gas_homeostasis0.74282754
103MP0001502_abnormal_circadian_rhythm0.73919538
104MP0005409_darkened_coat_color0.73847663
105MP0003953_abnormal_hormone_level0.72759781
106MP0002078_abnormal_glucose_homeostasis0.72682570
107MP0005275_abnormal_skin_tensile0.72243654
108MP0008961_abnormal_basal_metabolism0.70246614
109MP0003705_abnormal_hypodermis_morpholog0.69941498
110MP0006072_abnormal_retinal_apoptosis0.69776399
111MP0000266_abnormal_heart_morphology0.69278986
112MP0003300_gastrointestinal_ulcer0.68687383
113MP0002102_abnormal_ear_morphology0.68416945
114MP0005645_abnormal_hypothalamus_physiol0.68389004
115MP0003045_fibrosis0.68143202
116MP0002138_abnormal_hepatobiliary_system0.64623186
117MP0005386_behavior/neurological_phenoty0.63638836
118MP0004924_abnormal_behavior0.63638836
119MP0005164_abnormal_response_to0.63631335
120MP0001727_abnormal_embryo_implantation0.63233808
121MP0005084_abnormal_gallbladder_morpholo0.62078478
122MP0005623_abnormal_meninges_morphology0.61771452
123MP0002796_impaired_skin_barrier0.61300206
124MP0008872_abnormal_physiological_respon0.61222046
125MP0003221_abnormal_cardiomyocyte_apopto0.60698338
126MP0001944_abnormal_pancreas_morphology0.60374070
127MP0009780_abnormal_chondrocyte_physiolo0.60170607
128MP0001756_abnormal_urination0.59713086
129MP0001614_abnormal_blood_vessel0.59314214
130MP0005253_abnormal_eye_physiology0.57680343
131MP0005584_abnormal_enzyme/coenzyme_acti0.57610872
132MP0004043_abnormal_pH_regulation0.56175057
133MP0005646_abnormal_pituitary_gland0.53583341
134MP0004782_abnormal_surfactant_physiolog0.47856252
135MP0002733_abnormal_thermal_nociception0.46760969

Predicted human phenotypes

RankGene SetZ-score
1Ventricular tachycardia (HP:0004756)5.36268138
2Sudden death (HP:0001699)5.32491544
3Muscle fiber splitting (HP:0003555)5.21428895
4Atrial fibrillation (HP:0005110)4.47234641
5Calf muscle hypertrophy (HP:0008981)4.45460942
6Hyporeflexia of lower limbs (HP:0002600)4.44270336
7Muscle hypertrophy of the lower extremities (HP:0008968)4.21972885
8Exercise-induced myalgia (HP:0003738)4.14662883
9Primary atrial arrhythmia (HP:0001692)4.07494453
10Difficulty running (HP:0009046)4.06754866
11Right ventricular cardiomyopathy (HP:0011663)4.05906147
12Supraventricular arrhythmia (HP:0005115)3.95318983
13Lipoatrophy (HP:0100578)3.94861839
14Increased connective tissue (HP:0009025)3.94809269
15Supraventricular tachycardia (HP:0004755)3.87604114
16Myoglobinuria (HP:0002913)3.75456001
17Abnormality of the calf musculature (HP:0001430)3.41378463
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.38898129
19Abnormality of alanine metabolism (HP:0010916)3.38898129
20Hyperalaninemia (HP:0003348)3.38898129
21Abnormal eating behavior (HP:0100738)3.36391709
22Hyperglycinuria (HP:0003108)3.35892125
23Decreased circulating renin level (HP:0003351)3.31155501
24Syncope (HP:0001279)3.28609219
25Ketoacidosis (HP:0001993)3.25344026
26Abnormality of fatty-acid metabolism (HP:0004359)3.23371359
27Polycythemia (HP:0001901)3.21720958
28Hypoglycemic coma (HP:0001325)3.18906788
29Insulin resistance (HP:0000855)3.17185200
30Dilated cardiomyopathy (HP:0001644)3.13698322
31Prolonged QT interval (HP:0001657)3.11695606
32Adactyly (HP:0009776)3.07506804
33Exercise-induced muscle cramps (HP:0003710)3.03447565
34Palpitations (HP:0001962)3.00522478
35Ketosis (HP:0001946)2.91802108
36Hypoalphalipoproteinemia (HP:0003233)2.85697014
37EMG: myopathic abnormalities (HP:0003458)2.84671713
38Dicarboxylic aciduria (HP:0003215)2.83000349
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.83000349
40Epidermoid cyst (HP:0200040)2.82599365
41Deep venous thrombosis (HP:0002625)2.81468515
42Oligomenorrhea (HP:0000876)2.75988797
43Rhabdomyolysis (HP:0003201)2.75675153
44Myotonia (HP:0002486)2.73974478
45Frequent falls (HP:0002359)2.73240702
46Broad metatarsal (HP:0001783)2.72975843
47Polyphagia (HP:0002591)2.72331613
48Abnormality of glycine metabolism (HP:0010895)2.71894983
49Abnormality of serine family amino acid metabolism (HP:0010894)2.71894983
50Acanthosis nigricans (HP:0000956)2.67586253
51Type 1 muscle fiber predominance (HP:0003803)2.66825333
52Bundle branch block (HP:0011710)2.66714927
53Rimmed vacuoles (HP:0003805)2.66201785
54Atrioventricular block (HP:0001678)2.64344287
55Polydipsia (HP:0001959)2.63732733
56Abnormal drinking behavior (HP:0030082)2.63732733
57Delayed CNS myelination (HP:0002188)2.62273274
58Heart block (HP:0012722)2.61689186
59Increased variability in muscle fiber diameter (HP:0003557)2.58750903
60Prominent supraorbital ridges (HP:0000336)2.57181190
61Asymmetric septal hypertrophy (HP:0001670)2.56792397
62Cerebral hemorrhage (HP:0001342)2.55552339
63Hyperammonemia (HP:0001987)2.55074545
64Muscle fiber inclusion bodies (HP:0100299)2.53011640
65Distal lower limb muscle weakness (HP:0009053)2.51219011
66Abnormal atrioventricular conduction (HP:0005150)2.48851350
67Subaortic stenosis (HP:0001682)2.48201137
68Abnormality of the left ventricular outflow tract (HP:0011103)2.48201137
69Muscle stiffness (HP:0003552)2.46888850
70Hyperlipoproteinemia (HP:0010980)2.41878767
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41178031
72Insulin-resistant diabetes mellitus (HP:0000831)2.40183769
73Ventricular arrhythmia (HP:0004308)2.40102910
74Neck muscle weakness (HP:0000467)2.36765262
75Lymphangioma (HP:0100764)2.35686182
76Inability to walk (HP:0002540)2.32469216
77Increased muscle lipid content (HP:0009058)2.32236970
78Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.31022392
79Hypertriglyceridemia (HP:0002155)2.29688003
80Complement deficiency (HP:0004431)2.28621118
81Esophageal varix (HP:0002040)2.27549375
82Nemaline bodies (HP:0003798)2.26256606
83Difficulty climbing stairs (HP:0003551)2.24537575
84Spontaneous hematomas (HP:0007420)2.24157290
85Abnormality of skeletal muscle fiber size (HP:0012084)2.22103537
86Joint hemorrhage (HP:0005261)2.21119046
87Testicular atrophy (HP:0000029)2.20775674
88Congenital, generalized hypertrichosis (HP:0004540)2.20224517
89Congenital stationary night blindness (HP:0007642)2.20045750
90Abnormality of the ischium (HP:0003174)2.19921867
91Bone cyst (HP:0012062)2.18944767
92Hypoplastic ischia (HP:0003175)2.18097203
93Pancreatic cysts (HP:0001737)2.17370247
94Hypoplasia of the iris (HP:0007676)2.16835962
95Hepatic necrosis (HP:0002605)2.15277571
96Xanthomatosis (HP:0000991)2.12897359
97Pulmonary artery stenosis (HP:0004415)2.11725685
98Abnormality of the renal collecting system (HP:0004742)2.11158478
99Hemorrhage of the eye (HP:0011885)2.10692392
100Nephronophthisis (HP:0000090)2.10630335
101Skin nodule (HP:0200036)2.10159018
102Generalized aminoaciduria (HP:0002909)2.09234164
103Areflexia of lower limbs (HP:0002522)2.07962208
104Mesangial abnormality (HP:0001966)2.02370151
105Increased circulating renin level (HP:0000848)2.01956214
106Broad-based gait (HP:0002136)2.01802895
107Nausea (HP:0002018)2.01622068
108Duplicated collecting system (HP:0000081)2.01464865
109Attenuation of retinal blood vessels (HP:0007843)2.00897405
110Generalized muscle weakness (HP:0003324)2.00368942
111Increased corneal curvature (HP:0100692)1.99892725
112Keratoconus (HP:0000563)1.99892725
113Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99706410
114Pigmentary retinal degeneration (HP:0001146)1.99641926
115Cerebral edema (HP:0002181)1.99293719
116Abnormal EKG (HP:0003115)1.98960774
117Hematochezia (HP:0002573)1.98416727
118Mitochondrial inheritance (HP:0001427)1.97442869
119Large for gestational age (HP:0001520)1.96812394
120Renal Fanconi syndrome (HP:0001994)1.96714183
121Toxemia of pregnancy (HP:0100603)1.96091249
122Hepatocellular necrosis (HP:0001404)1.95848575
123Renal cortical cysts (HP:0000803)1.95097512
124Prolonged partial thromboplastin time (HP:0003645)1.94936403
125Hyperinsulinemic hypoglycemia (HP:0000825)1.94313661
126Abnormality of the renal cortex (HP:0011035)1.94086960
127Infantile muscular hypotonia (HP:0008947)1.92953270
128Spinal rigidity (HP:0003306)1.92348916
129Abnormal hemoglobin (HP:0011902)1.92204193
130Abolished electroretinogram (ERG) (HP:0000550)1.91996157
131Reduced subcutaneous adipose tissue (HP:0003758)1.91066551
132Axonal loss (HP:0003447)1.90397134
133Exertional dyspnea (HP:0002875)1.90387476
134Increased serum pyruvate (HP:0003542)1.89578130
135Acute necrotizing encephalopathy (HP:0006965)1.88872407
136Myocardial infarction (HP:0001658)1.88556260
137Polyuria (HP:0000103)1.87086566
138Abnormal urine output (HP:0012590)1.86649178
139Facial diplegia (HP:0001349)1.86562990
140Gowers sign (HP:0003391)1.86345703
141Opisthotonus (HP:0002179)1.86282375
142True hermaphroditism (HP:0010459)1.85569460
143Metabolic acidosis (HP:0001942)1.85495665
144Abnormality of midbrain morphology (HP:0002418)1.85049430
145Molar tooth sign on MRI (HP:0002419)1.85049430
146Hyperglycemia (HP:0003074)1.84250072
147Metaphyseal dysplasia (HP:0100255)1.84203442
148Back pain (HP:0003418)1.83449812
149Increased intramyocellular lipid droplets (HP:0012240)1.82588160
150Pancreatic fibrosis (HP:0100732)1.82516326
151Pancreatic islet-cell hyperplasia (HP:0004510)1.81421680
152Hyperglycinemia (HP:0002154)1.81295125
153Nonimmune hydrops fetalis (HP:0001790)1.81203223
154Nephritis (HP:0000123)1.79251548
155Cavernous hemangioma (HP:0001048)1.78928486
156Ventricular fibrillation (HP:0001663)1.77150065
157Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.77107351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.59123294
2KDR4.93440984
3FRK4.07799017
4TTN3.02125935
5TGFBR22.75593892
6MYLK2.57224298
7WNK42.39350237
8MAPKAPK32.27808244
9BCKDK2.24794113
10INSRR2.17325697
11PHKG12.07560511
12PHKG22.07560511
13CAMKK22.01808274
14EPHB22.01789847
15STK392.01071257
16MAP4K21.98789704
17OBSCN1.94474470
18ADRBK21.92177677
19PDK21.85839240
20CAMK1D1.85548749
21PDK31.72059318
22PDK41.72059318
23LMTK21.65757499
24ADRBK11.64628738
25RIPK11.63743808
26SIK11.62288560
27DMPK1.61292602
28CAMK1G1.54120515
29GRK51.52947698
30PIK3CA1.52651062
31KIT1.47660051
32WNK31.41736090
33EPHB11.39306604
34OXSR11.33552955
35BLK1.32100170
36ZAK1.30415259
37PRKAA21.27847845
38MAPK131.25390213
39TXK1.25018413
40MAPK121.20982873
41TRIB31.15943774
42NUAK11.15584005
43ERN11.14551677
44TGFBR11.14526281
45PTK2B1.14132686
46NLK1.11570100
47STK38L1.09951812
48DDR21.09459482
49PRKD11.09219034
50TLK11.08873043
51FGFR41.07617436
52PKN11.05323882
53FER1.04962554
54LATS11.04593677
55ABL21.03688995
56GRK71.02710431
57IRAK31.00216807
58ACVR1B0.97157546
59JAK10.96965526
60GRK10.96137095
61CASK0.93004464
62PRKG10.92086443
63MAP2K30.90916069
64MAPKAPK50.85858040
65MAP3K30.85487643
66MAP3K70.85370443
67MAP3K140.80682401
68PINK10.79389080
69ERBB30.77227526
70MARK10.76055318
71PDGFRA0.72381149
72CAMK40.70240080
73CSK0.69739164
74PAK30.69356616
75FGFR20.67523867
76TEC0.67029838
77PDPK10.65556371
78IRAK10.64906844
79MST1R0.64692550
80PRKCE0.64638120
81MUSK0.63977922
82PRKAA10.62901666
83MAPK150.61565788
84EPHA30.60866442
85TRPM70.60372497
86MAPK70.60028307
87PTK60.58373679
88PIK3CG0.58001892
89PRKCH0.57458051
90CAMK10.57265759
91FGFR30.56246969
92TNK20.54987655
93STK30.54229248
94FLT30.54185205
95JAK20.53530593
96BMPR1B0.53118014
97ROCK10.50839607
98CAMK2D0.50742047
99WNK10.50615027
100MAP3K40.50413875
101BCR0.50042884
102CCNB10.48421997
103GSK3A0.47512630
104MARK20.47509961
105MAP2K60.47503163
106ABL10.46575154
107ITK0.45118064
108CAMK2A0.44571535
109MKNK20.44526846
110JAK30.43044374
111PRKCG0.42163383
112IGF1R0.41170285
113TAOK30.40899911
114PRKACG0.40194937
115DAPK20.39905858
116PRKG20.39741453
117CDK90.38093826
118PDK10.37170854
119PDGFRB0.37016119
120FES0.36427056
121MET0.36093042
122MAPK40.35917507
123CDC42BPA0.35292134
124PRKACA0.35098283
125MAP2K10.34399047
126PRKD20.34100669
127RPS6KA30.33534410
128MAP3K60.33415629
129PKN20.32472424
130PRKCQ0.32307170
131PRKACB0.32258860
132MAP3K130.32108087
133EIF2AK20.31923725
134MAP3K10.31810715
135MAP2K40.31351331
136MAPK30.30517365
137PRKCA0.29901124
138STK240.29691650
139SGK10.26723659
140STK110.26512325
141TYK20.26087068

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.48808213
2Fatty acid degradation_Homo sapiens_hsa000713.14164613
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.10140996
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.95322154
5PPAR signaling pathway_Homo sapiens_hsa033202.86171601
6Fatty acid metabolism_Homo sapiens_hsa012122.75845179
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.53309021
8Fatty acid elongation_Homo sapiens_hsa000622.02226887
9Fatty acid biosynthesis_Homo sapiens_hsa000611.99544233
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.97951980
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95120212
12Butanoate metabolism_Homo sapiens_hsa006501.91605749
13Dilated cardiomyopathy_Homo sapiens_hsa054141.90709001
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79126847
15Tryptophan metabolism_Homo sapiens_hsa003801.76695801
16Pyruvate metabolism_Homo sapiens_hsa006201.69874088
17beta-Alanine metabolism_Homo sapiens_hsa004101.69276269
18Arginine biosynthesis_Homo sapiens_hsa002201.68664007
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64253633
20Caffeine metabolism_Homo sapiens_hsa002321.55359767
21Cardiac muscle contraction_Homo sapiens_hsa042601.54870135
22Complement and coagulation cascades_Homo sapiens_hsa046101.53333013
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49124885
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.45927812
25Peroxisome_Homo sapiens_hsa041461.45578414
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41637492
27Phototransduction_Homo sapiens_hsa047441.39756259
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38354158
29Staphylococcus aureus infection_Homo sapiens_hsa051501.36456575
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.35277705
31Carbon metabolism_Homo sapiens_hsa012001.31664120
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31059643
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21505801
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18535067
35ECM-receptor interaction_Homo sapiens_hsa045121.10260444
36Oxidative phosphorylation_Homo sapiens_hsa001901.09061546
37Phenylalanine metabolism_Homo sapiens_hsa003601.08708964
38Glycerolipid metabolism_Homo sapiens_hsa005611.04079339
39ABC transporters_Homo sapiens_hsa020101.04047541
40Fat digestion and absorption_Homo sapiens_hsa049751.03961397
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01310716
42Insulin resistance_Homo sapiens_hsa049311.00888133
43Nitrogen metabolism_Homo sapiens_hsa009101.00718423
44Ether lipid metabolism_Homo sapiens_hsa005650.97677306
45Bile secretion_Homo sapiens_hsa049760.94128353
46Morphine addiction_Homo sapiens_hsa050320.91654046
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91227855
48Parkinsons disease_Homo sapiens_hsa050120.89341235
49Starch and sucrose metabolism_Homo sapiens_hsa005000.88982494
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.86163035
51Alzheimers disease_Homo sapiens_hsa050100.85980878
52Tyrosine metabolism_Homo sapiens_hsa003500.85831047
53Renin secretion_Homo sapiens_hsa049240.84662488
54Lysine degradation_Homo sapiens_hsa003100.83598244
55Circadian rhythm_Homo sapiens_hsa047100.82897903
56Malaria_Homo sapiens_hsa051440.81292694
57Focal adhesion_Homo sapiens_hsa045100.79776823
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78980120
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78339537
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78109130
61Asthma_Homo sapiens_hsa053100.77543743
62AMPK signaling pathway_Homo sapiens_hsa041520.76275705
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74000455
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.73893526
65Arginine and proline metabolism_Homo sapiens_hsa003300.72446069
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70275872
67Sulfur relay system_Homo sapiens_hsa041220.70228495
68Olfactory transduction_Homo sapiens_hsa047400.70118925
69Histidine metabolism_Homo sapiens_hsa003400.69650986
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68980533
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.67951883
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66973930
73Retinol metabolism_Homo sapiens_hsa008300.66190117
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64388923
75Arachidonic acid metabolism_Homo sapiens_hsa005900.62854407
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60562380
77Dorso-ventral axis formation_Homo sapiens_hsa043200.60003705
78Glucagon signaling pathway_Homo sapiens_hsa049220.59392433
79Circadian entrainment_Homo sapiens_hsa047130.59125117
80Glutathione metabolism_Homo sapiens_hsa004800.58733438
81Ovarian steroidogenesis_Homo sapiens_hsa049130.58173670
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57296705
83Viral myocarditis_Homo sapiens_hsa054160.54629433
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52599417
85Regulation of autophagy_Homo sapiens_hsa041400.52558791
86Calcium signaling pathway_Homo sapiens_hsa040200.52279161
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.51515832
88Insulin secretion_Homo sapiens_hsa049110.51486937
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50433960
90cAMP signaling pathway_Homo sapiens_hsa040240.50088458
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49943163
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49608224
93Chemical carcinogenesis_Homo sapiens_hsa052040.48029951
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47407333
95Amoebiasis_Homo sapiens_hsa051460.47287433
96GABAergic synapse_Homo sapiens_hsa047270.46581248
97Vitamin digestion and absorption_Homo sapiens_hsa049770.46354722
98Insulin signaling pathway_Homo sapiens_hsa049100.45478136
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44736092
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.44640773
101African trypanosomiasis_Homo sapiens_hsa051430.44574153
102Axon guidance_Homo sapiens_hsa043600.42982688
103Selenocompound metabolism_Homo sapiens_hsa004500.42043228
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.41575988
105Protein digestion and absorption_Homo sapiens_hsa049740.40721407
106Nicotine addiction_Homo sapiens_hsa050330.39767959
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39661362
108Serotonergic synapse_Homo sapiens_hsa047260.39046609
109Type II diabetes mellitus_Homo sapiens_hsa049300.38791702
110Rap1 signaling pathway_Homo sapiens_hsa040150.38296591
111Adherens junction_Homo sapiens_hsa045200.38150298
112Sulfur metabolism_Homo sapiens_hsa009200.37816580
113Protein export_Homo sapiens_hsa030600.37650053
114Metabolic pathways_Homo sapiens_hsa011000.37397515
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36867244
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36524541
117Allograft rejection_Homo sapiens_hsa053300.35813919
118Huntingtons disease_Homo sapiens_hsa050160.33591603
119Oxytocin signaling pathway_Homo sapiens_hsa049210.33234437
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32774986
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32012059
122Gastric acid secretion_Homo sapiens_hsa049710.29651885
123Ras signaling pathway_Homo sapiens_hsa040140.29461731
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28820593
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27725731
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27188698
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27168565
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25547276
129Salivary secretion_Homo sapiens_hsa049700.25040581
130Taste transduction_Homo sapiens_hsa047420.24263626
131Linoleic acid metabolism_Homo sapiens_hsa005910.23104673

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