CD300LF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.40888342
2positive regulation by symbiont of host defense response (GO:0052509)5.60065180
3modulation by symbiont of host defense response (GO:0052031)5.60065180
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.60065180
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.60065180
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.60065180
7modulation by symbiont of host immune response (GO:0052553)5.60065180
8response to peptidoglycan (GO:0032494)5.42542787
9leukocyte aggregation (GO:0070486)5.30699780
10respiratory burst (GO:0045730)5.18801037
11neutrophil activation (GO:0042119)4.94692858
12superoxide anion generation (GO:0042554)4.84272978
13cellular extravasation (GO:0045123)4.83456732
14production of molecular mediator involved in inflammatory response (GO:0002532)4.77725253
15granulocyte activation (GO:0036230)4.73366973
16antigen processing and presentation of endogenous antigen (GO:0019883)4.69324246
17positive regulation of mast cell activation (GO:0033005)4.60504046
18positive regulation of mast cell degranulation (GO:0043306)4.50638343
19positive regulation of mast cell activation involved in immune response (GO:0033008)4.50638343
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49610897
21leukocyte migration involved in inflammatory response (GO:0002523)4.46177514
22regulation of mast cell degranulation (GO:0043304)4.45567327
23response to host immune response (GO:0052572)4.43011530
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.43011530
25detection of other organism (GO:0098543)4.36096862
26neutrophil mediated immunity (GO:0002446)4.35370776
27macrophage activation involved in immune response (GO:0002281)4.34983517
28regulation of B cell receptor signaling pathway (GO:0050855)4.34042513
29cellular response to interleukin-15 (GO:0071350)4.28394589
30regulation of mast cell activation (GO:0033003)4.21796709
31response to interleukin-15 (GO:0070672)4.17602204
32regulation of mast cell activation involved in immune response (GO:0033006)4.16809127
33negative regulation of lymphocyte mediated immunity (GO:0002707)4.16494565
34regulation of gamma-delta T cell activation (GO:0046643)4.15729714
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07525116
36positive regulation of monocyte chemotaxis (GO:0090026)4.01306514
37negative regulation of T cell mediated immunity (GO:0002710)3.97774576
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95909871
39positive regulation of cellular amide metabolic process (GO:0034250)3.93455367
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.90142970
41response to host (GO:0075136)3.90142970
42response to host defenses (GO:0052200)3.90142970
43negative regulation of mast cell activation (GO:0033004)3.88215363
44microglial cell activation (GO:0001774)3.81321914
45regulation of myeloid leukocyte mediated immunity (GO:0002886)3.81150534
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.78011385
47myeloid cell activation involved in immune response (GO:0002275)3.77183753
48negative regulation of leukocyte mediated immunity (GO:0002704)3.73811950
49hydrogen peroxide biosynthetic process (GO:0050665)3.70936096
50detection of bacterium (GO:0016045)3.70088570
51regulation of interferon-beta biosynthetic process (GO:0045357)3.68874490
52regulation of gamma-delta T cell differentiation (GO:0045586)3.65168425
53regulation of leukocyte degranulation (GO:0043300)3.59990542
54neutrophil chemotaxis (GO:0030593)3.59855927
55immunoglobulin mediated immune response (GO:0016064)3.57699527
56positive regulation of antigen processing and presentation (GO:0002579)3.56711566
57positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.56514489
58mast cell activation (GO:0045576)3.54420941
59regulation of dendritic cell antigen processing and presentation (GO:0002604)3.54003397
60detection of molecule of bacterial origin (GO:0032490)3.53556269
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.51473133
62phagosome maturation (GO:0090382)3.50489274
63neutrophil migration (GO:1990266)3.49140129
64macrophage activation (GO:0042116)3.48083284
65regulation of T cell mediated cytotoxicity (GO:0001914)3.44917266
66B cell mediated immunity (GO:0019724)3.40581837
67detection of external biotic stimulus (GO:0098581)3.38490893
68response to muramyl dipeptide (GO:0032495)3.35878952
69positive thymic T cell selection (GO:0045059)3.30750773
70regulation of B cell differentiation (GO:0045577)3.29844727
71positive regulation of interleukin-17 production (GO:0032740)3.29668087
72myeloid leukocyte mediated immunity (GO:0002444)3.28270249
73negative thymic T cell selection (GO:0045060)3.27598788
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.27116873
75antigen processing and presentation via MHC class Ib (GO:0002475)3.26956661
76reactive oxygen species biosynthetic process (GO:1903409)3.26063278
77negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23104421
78tolerance induction (GO:0002507)3.23030732
79negative T cell selection (GO:0043383)3.22439336
80granulocyte chemotaxis (GO:0071621)3.19759124
81lipopolysaccharide-mediated signaling pathway (GO:0031663)3.19650349
82granulocyte migration (GO:0097530)3.16779804
83response to fungus (GO:0009620)3.15365691
84regulation of monocyte chemotaxis (GO:0090025)3.14940367
85positive regulation of leukocyte degranulation (GO:0043302)3.14484176
86negative regulation of interleukin-17 production (GO:0032700)3.12959437
87positive regulation of B cell differentiation (GO:0045579)3.11333931
88dendritic cell chemotaxis (GO:0002407)3.11167963
89positive regulation of toll-like receptor signaling pathway (GO:0034123)3.11005385
90leukotriene metabolic process (GO:0006691)3.10805800
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10376409
92negative regulation of cell killing (GO:0031342)3.10376409
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.08493698
94positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.07451206
95B cell receptor signaling pathway (GO:0050853)3.06182039
96regulation of antigen processing and presentation (GO:0002577)3.04716912
97negative regulation of innate immune response (GO:0045824)3.04088491
98dendritic cell migration (GO:0036336)3.02895654
99regulation of tolerance induction (GO:0002643)3.02036145
100interferon-gamma-mediated signaling pathway (GO:0060333)3.01704421
101negative regulation of interleukin-6 production (GO:0032715)3.00613408
102regulation of alpha-beta T cell proliferation (GO:0046640)2.99535946
103negative regulation of interleukin-12 production (GO:0032695)2.99124284
104regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98044625
105regulation of natural killer cell mediated immunity (GO:0002715)2.98044625
106detection of biotic stimulus (GO:0009595)2.97874803
107T-helper 1 type immune response (GO:0042088)2.97414000
108leukocyte mediated cytotoxicity (GO:0001909)2.97169686
109leukocyte degranulation (GO:0043299)2.96154883
110defense response to protozoan (GO:0042832)2.93819955
111positive regulation of interferon-alpha production (GO:0032727)2.93450955
112positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92409187
113I-kappaB phosphorylation (GO:0007252)2.91909590
114regulation of germinal center formation (GO:0002634)2.91491654
115negative regulation of cytokine production involved in immune response (GO:0002719)2.91431230
116myeloid leukocyte activation (GO:0002274)2.91021969
117positive regulation of gamma-delta T cell activation (GO:0046645)2.90914300
118regulation of leukocyte mediated cytotoxicity (GO:0001910)2.87950779
119negative regulation of interleukin-1 beta production (GO:0032691)2.87887394
120regulation of regulated secretory pathway (GO:1903305)2.87743631
121regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87576177
122negative regulation of interleukin-1 production (GO:0032692)2.87477924
123positive regulation of chemokine biosynthetic process (GO:0045080)2.86245771
124positive regulation of acute inflammatory response (GO:0002675)2.84193537
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84069606
126eosinophil migration (GO:0072677)2.83478323
127regulation of T cell tolerance induction (GO:0002664)2.82353846
128lipoxygenase pathway (GO:0019372)2.80038706
129regulation of interferon-alpha production (GO:0032647)2.79204085
130positive regulation of interleukin-1 beta secretion (GO:0050718)2.75420881
131regulation of interleukin-17 production (GO:0032660)2.71911098
132positive regulation of heat generation (GO:0031652)2.70695064
133superoxide metabolic process (GO:0006801)2.70320818
134regulation of interleukin-8 biosynthetic process (GO:0045414)2.65910543
135leukocyte cell-cell adhesion (GO:0007159)2.65102029
136leukocyte chemotaxis (GO:0030595)2.62977309
137regulation of activation of Janus kinase activity (GO:0010533)2.62024628
138positive regulation of interleukin-10 production (GO:0032733)2.60293113
139regulation of interleukin-6 biosynthetic process (GO:0045408)2.59985897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.99202743
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.44785560
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.69003204
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.58496954
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42528791
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.28963728
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69156589
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59978334
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59315674
10VDR_21846776_ChIP-Seq_THP-1_Human2.49931067
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41884295
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40855346
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30776998
14MAF_26560356_Chip-Seq_TH1_Human2.28627736
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23267800
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.19607765
17UTX_26944678_Chip-Seq_JUKART_Human2.14544053
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09370314
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07233202
20MYB_26560356_Chip-Seq_TH1_Human1.96836113
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90930439
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88123041
23VDR_24787735_ChIP-Seq_THP-1_Human1.85867678
24MYC_22102868_ChIP-Seq_BL_Human1.82357107
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80142707
26GATA3_27048872_Chip-Seq_THYMUS_Human1.78507921
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.76880058
28GBX2_23144817_ChIP-Seq_PC3_Human1.73634468
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72660407
30PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70723562
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.70481405
32MAF_26560356_Chip-Seq_TH2_Human1.70091077
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69009651
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68359357
35GATA1_22025678_ChIP-Seq_K562_Human1.63473439
36TCF7_22412390_ChIP-Seq_EML_Mouse1.62749892
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62218637
38* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61176006
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60181412
40* SPI1_23547873_ChIP-Seq_NB4_Human1.59964460
41RUNX_20019798_ChIP-Seq_JUKART_Human1.58392170
42GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53364807
43SCL_19346495_ChIP-Seq_HPC-7_Human1.52751973
44* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52407638
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52114225
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.49223549
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47048921
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46106946
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40923821
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39976287
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39541402
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38699097
53PU_27001747_Chip-Seq_BMDM_Mouse1.35976170
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34444825
55KDM2B_26808549_Chip-Seq_DND41_Human1.33858832
56SPI1_23127762_ChIP-Seq_K562_Human1.29725565
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29039516
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28994698
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27588686
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26107333
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25658303
62VDR_22108803_ChIP-Seq_LS180_Human1.25317750
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24864143
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24502248
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23656666
66* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21950572
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20740287
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.20659684
69GATA1_19941826_ChIP-Seq_K562_Human1.20295372
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20047262
71* BCL6_27268052_Chip-Seq_Bcells_Human1.19642973
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19452575
73* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19239969
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19041494
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18459028
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18214049
77IGF1R_20145208_ChIP-Seq_DFB_Human1.18038092
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.17903610
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14659556
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14479734
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13601459
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13064472
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.11797106
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11647923
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09803295
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.07864878
87P53_22387025_ChIP-Seq_ESCs_Mouse1.07857589
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07442093
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06399013
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06357137
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06190866
92VDR_24763502_ChIP-Seq_THP-1_Human1.06137527
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.06049306
94STAT1_20625510_ChIP-Seq_HELA_Human1.05092556
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.04812837
96TAF15_26573619_Chip-Seq_HEK293_Human1.04792688
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04500997
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04370143
99P300_19829295_ChIP-Seq_ESCs_Human1.04027138
100STAT3_18555785_Chip-Seq_ESCs_Mouse1.03990737
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03609479
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03158270
103BCOR_27268052_Chip-Seq_Bcells_Human1.02893236
104PU1_27457419_Chip-Seq_LIVER_Mouse1.02525199
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01775310
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01481100
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01411127
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.01247385
109* RUNX1_22412390_ChIP-Seq_EML_Mouse1.01020204
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00293514
111CMYC_18555785_Chip-Seq_ESCs_Mouse0.98973370
112RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98323999
113* ER_23166858_ChIP-Seq_MCF-7_Human0.98303261
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97572284
115NMYC_18555785_Chip-Seq_ESCs_Mouse0.97190407
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96455206
117TP53_16413492_ChIP-PET_HCT116_Human0.96170580
118MYB_26560356_Chip-Seq_TH2_Human0.96129259
119* SPI1_20517297_ChIP-Seq_HL60_Human0.95831204
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95415015
121LXR_22292898_ChIP-Seq_THP-1_Human0.94568740
122RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93821867
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.93756409
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93231075
125GATA2_19941826_ChIP-Seq_K562_Human0.92742097
126RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92417356
127P300_18555785_Chip-Seq_ESCs_Mouse0.92389467
128JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91804593
129* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91734949
130SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89509299
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88534460
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88534460
133TFEB_21752829_ChIP-Seq_HELA_Human0.87679401
134TP53_18474530_ChIP-ChIP_U2OS_Human0.87323642
135OCT4_18555785_Chip-Seq_ESCs_Mouse0.86289346
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.86250115
137SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86083372
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.85902706
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.85214269
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85186021
141EZH2_22144423_ChIP-Seq_EOC_Human0.84851138
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84749322
143GATA3_26560356_Chip-Seq_TH2_Human0.84709030
144ESRRB_18555785_Chip-Seq_ESCs_Mouse0.84174561
145FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83578371
146ZFX_18555785_Chip-Seq_ESCs_Mouse0.82994879
147SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.82946395
148CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82690801
149KLF4_18555785_Chip-Seq_ESCs_Mouse0.82667854
150FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81671293
151KDM2B_26808549_Chip-Seq_JURKAT_Human0.81461234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.15025007
2MP0001835_abnormal_antigen_presentation3.97718690
3MP0002419_abnormal_innate_immunity3.50054936
4MP0002148_abnormal_hypersensitivity_rea3.38918572
5MP0009785_altered_susceptibility_to3.38202327
6MP0003303_peritoneal_inflammation3.28476856
7MP0003724_increased_susceptibility_to3.27760136
8* MP0005000_abnormal_immune_tolerance2.95996362
9MP0000569_abnormal_digit_pigmentation2.84327214
10MP0005025_abnormal_response_to2.78220598
11MP0005387_immune_system_phenotype2.58715350
12MP0001790_abnormal_immune_system2.58715350
13MP0005174_abnormal_tail_pigmentation2.57676259
14MP0002452_abnormal_antigen_presenting2.52831037
15MP0006082_CNS_inflammation2.45504946
16MP0002277_abnormal_respiratory_mucosa2.42479392
17MP0001800_abnormal_humoral_immune2.36790411
18MP0004510_myositis2.30204612
19* MP0002723_abnormal_immune_serum2.28992975
20MP0005058_abnormal_lysosome_morphology2.26657305
21MP0009278_abnormal_bone_marrow2.24808400
22MP0005671_abnormal_response_to2.23047327
23MP0001533_abnormal_skeleton_physiology2.18822192
24MP0001819_abnormal_immune_cell2.17332518
25MP0002420_abnormal_adaptive_immunity2.16054705
26MP0008260_abnormal_autophagy2.11877740
27MP0003183_abnormal_peptide_metabolism2.10378322
28MP0005464_abnormal_platelet_physiology2.10343919
29MP0003763_abnormal_thymus_physiology2.03328935
30MP0002405_respiratory_system_inflammati2.02842135
31MP0003136_yellow_coat_color1.99413690
32MP0009764_decreased_sensitivity_to1.91986806
33MP0003172_abnormal_lysosome_physiology1.90178198
34MP0001853_heart_inflammation1.86914393
35MP0000015_abnormal_ear_pigmentation1.84776835
36MP0000343_altered_response_to1.77776363
37MP0000685_abnormal_immune_system1.69108961
38MP0005310_abnormal_salivary_gland1.68058452
39MP0001845_abnormal_inflammatory_respons1.65764179
40MP0004381_abnormal_hair_follicle1.64061692
41MP0003075_altered_response_to1.55476732
42MP0003866_abnormal_defecation1.52453260
43MP0003448_altered_tumor_morphology1.50659114
44MP0002933_joint_inflammation1.49220094
45MP0001851_eye_inflammation1.45228349
46MP0002396_abnormal_hematopoietic_system1.42864635
47MP0000716_abnormal_immune_system1.41924951
48MP0002998_abnormal_bone_remodeling1.36496720
49MP0000703_abnormal_thymus_morphology1.34871970
50MP0005167_abnormal_blood-brain_barrier1.31855436
51MP0000465_gastrointestinal_hemorrhage1.31197975
52MP0003690_abnormal_glial_cell1.29711222
53MP0003878_abnormal_ear_physiology1.29340306
54MP0005377_hearing/vestibular/ear_phenot1.29340306
55MP0002132_abnormal_respiratory_system1.27995706
56MP0008469_abnormal_protein_level1.26469802
57MP0003828_pulmonary_edema1.26425628
58MP0005409_darkened_coat_color1.23767070
59MP0006292_abnormal_olfactory_placode1.23153081
60MP0004947_skin_inflammation1.21171878
61MP0002102_abnormal_ear_morphology1.20042902
62MP0000858_altered_metastatic_potential1.19512076
63MP0004742_abnormal_vestibular_system1.19389289
64MP0005164_abnormal_response_to1.18839846
65MP0004883_abnormal_blood_vessel1.17475750
66MP0002398_abnormal_bone_marrow1.17321791
67MP0005390_skeleton_phenotype1.16453275
68MP0005166_decreased_susceptibility_to1.16013301
69MP0003656_abnormal_erythrocyte_physiolo1.13989321
70MP0002166_altered_tumor_susceptibility1.13703687
71MP0005075_abnormal_melanosome_morpholog1.10409727
72MP0010155_abnormal_intestine_physiology1.09789961
73MP0002429_abnormal_blood_cell1.04281513
74MP0003806_abnormal_nucleotide_metabolis1.03970926
75MP0005083_abnormal_biliary_tract1.02071386
76MP0000689_abnormal_spleen_morphology0.98430518
77* MP0000920_abnormal_myelination0.98144436
78MP0004782_abnormal_surfactant_physiolog0.98067881
79MP0005171_absent_coat_pigmentation0.97895688
80MP0005451_abnormal_body_composition0.92690265
81MP0002006_tumorigenesis0.92550624
82MP0001545_abnormal_hematopoietic_system0.89005948
83MP0005397_hematopoietic_system_phenotyp0.89005948
84MP0009333_abnormal_splenocyte_physiolog0.88484403
85MP0001986_abnormal_taste_sensitivity0.88343699
86MP0002722_abnormal_immune_system0.87105939
87MP0003191_abnormal_cellular_cholesterol0.85317391
88MP0002254_reproductive_system_inflammat0.82773900
89MP0009765_abnormal_xenobiotic_induced0.82532791
90MP0001188_hyperpigmentation0.81055795
91MP0001873_stomach_inflammation0.80201538
92MP0010386_abnormal_urinary_bladder0.77506227
93MP0008004_abnormal_stomach_pH0.76935106
94MP0001958_emphysema0.75147197
95MP0002095_abnormal_skin_pigmentation0.73896836
96MP0005257_abnormal_intraocular_pressure0.71930024
97MP0000604_amyloidosis0.69496836
98MP0001663_abnormal_digestive_system0.69440430
99MP0009840_abnormal_foam_cell0.67941093
100MP0003795_abnormal_bone_structure0.66348275
101MP0003045_fibrosis0.65279822
102MP0003950_abnormal_plasma_membrane0.63903868
103MP0009763_increased_sensitivity_to0.63225963
104MP0004808_abnormal_hematopoietic_stem0.63083471
105MP0000371_diluted_coat_color0.62597652
106MP0002138_abnormal_hepatobiliary_system0.62184140
107MP0000249_abnormal_blood_vessel0.61459530
108MP0003252_abnormal_bile_duct0.59995592
109MP0005365_abnormal_bile_salt0.58664934
110MP0000372_irregular_coat_pigmentation0.57663550
111MP0004130_abnormal_muscle_cell0.57261592
112MP0005319_abnormal_enzyme/_coenzyme0.53266930
113MP0003453_abnormal_keratinocyte_physiol0.51394383
114MP0005388_respiratory_system_phenotype0.51376998
115MP0002133_abnormal_respiratory_system0.51376998
116MP0000609_abnormal_liver_physiology0.51217592
117MP0002735_abnormal_chemical_nociception0.50962429
118MP0003638_abnormal_response/metabolism_0.50362311
119MP0001765_abnormal_ion_homeostasis0.50304245
120MP0003300_gastrointestinal_ulcer0.49041911
121MP0009046_muscle_twitch0.48989899
122MP0000566_synostosis0.48552682
123MP0000490_abnormal_crypts_of0.47567388
124MP0000767_abnormal_smooth_muscle0.47538291

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.26414347
2Eczematoid dermatitis (HP:0000976)7.32272130
3Recurrent bacterial skin infections (HP:0005406)7.22595037
4Recurrent gram-negative bacterial infections (HP:0005420)6.59945148
5Abnormality of macrophages (HP:0004311)5.25004371
6Obstructive lung disease (HP:0006536)4.99246894
7Chronic obstructive pulmonary disease (HP:0006510)4.99246894
8Gingivitis (HP:0000230)4.70945580
9Mediastinal lymphadenopathy (HP:0100721)4.70878353
10Stomatitis (HP:0010280)4.63930413
11Recurrent skin infections (HP:0001581)4.60238424
12Retrobulbar optic neuritis (HP:0100654)4.25016513
13Optic neuritis (HP:0100653)4.25016513
14Myositis (HP:0100614)4.21288106
15Gastrointestinal infarctions (HP:0005244)4.12532596
16Orchitis (HP:0100796)4.09038183
17Recurrent fungal infections (HP:0002841)3.93868482
18Vacuolated lymphocytes (HP:0001922)3.85720687
19Recurrent cutaneous fungal infections (HP:0011370)3.52618799
20Chronic mucocutaneous candidiasis (HP:0002728)3.52618799
21Prostate neoplasm (HP:0100787)3.51591972
22T lymphocytopenia (HP:0005403)3.43483148
23Abnormality of T cell number (HP:0011839)3.26858669
24Meningitis (HP:0001287)3.22657409
25Increased cerebral lipofuscin (HP:0011813)3.17432468
26Recurrent pneumonia (HP:0006532)3.12714607
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.12399688
28Urticaria (HP:0001025)3.06024046
29Elevated erythrocyte sedimentation rate (HP:0003565)3.04213815
30Cellulitis (HP:0100658)3.00013446
31Chest pain (HP:0100749)2.94080086
32Anorexia (HP:0002039)2.93738495
33Vasculitis (HP:0002633)2.90334715
34Abnormality of T cells (HP:0002843)2.82560128
35Panhypogammaglobulinemia (HP:0003139)2.82186021
36Amyloidosis (HP:0011034)2.81481469
37Cheilitis (HP:0100825)2.74492372
38Increased IgE level (HP:0003212)2.70873994
39Parakeratosis (HP:0001036)2.70575599
40Episodic fever (HP:0001954)2.63261496
41Spontaneous hematomas (HP:0007420)2.60598672
42Periodontitis (HP:0000704)2.57578976
43Keratoconjunctivitis sicca (HP:0001097)2.53425537
44Thick nail (HP:0001805)2.53315174
45Joint hemorrhage (HP:0005261)2.52960837
46Osteomyelitis (HP:0002754)2.50748750
47Severe combined immunodeficiency (HP:0004430)2.49223611
48Axonal loss (HP:0003447)2.49023793
49Recurrent lower respiratory tract infections (HP:0002783)2.46444550
50Hemoptysis (HP:0002105)2.45758600
51Granulocytopenia (HP:0001913)2.44898807
52Vertigo (HP:0002321)2.43261835
53Hypochromic microcytic anemia (HP:0004840)2.41945019
54Hepatosplenomegaly (HP:0001433)2.41680191
55Loss of speech (HP:0002371)2.41507988
56Abnormality of the pleura (HP:0002103)2.41427312
57Hypochromic anemia (HP:0001931)2.39364118
58Abnormality of glycolipid metabolism (HP:0010969)2.39088893
59Abnormality of liposaccharide metabolism (HP:0010968)2.39088893
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.39088893
61Systemic lupus erythematosus (HP:0002725)2.37157026
62Pulmonary infiltrates (HP:0002113)2.35126954
63Pustule (HP:0200039)2.34182882
64Keratoconjunctivitis (HP:0001096)2.33398751
65Polyneuropathy (HP:0001271)2.31821041
66Abnormality of T cell physiology (HP:0011840)2.30221948
67Recurrent viral infections (HP:0004429)2.26521062
68Purpura (HP:0000979)2.23773127
69IgG deficiency (HP:0004315)2.23414562
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23144314
71Disinhibition (HP:0000734)2.21740138
72Abnormality of eosinophils (HP:0001879)2.21679993
73Combined immunodeficiency (HP:0005387)2.20959252
74Increased serum ferritin (HP:0003281)2.15518536
75Autoimmune thrombocytopenia (HP:0001973)2.15225226
76Basal ganglia calcification (HP:0002135)2.13275194
77Gingival bleeding (HP:0000225)2.12788872
78Leukocytosis (HP:0001974)2.12426508
79Abnormality of the prostate (HP:0008775)2.08114917
80Abnormality of the endocardium (HP:0004306)2.07309758
81White forelock (HP:0002211)2.04386802
82Hypergammaglobulinemia (HP:0010702)2.02821171
83Abnormality of iron homeostasis (HP:0011031)2.02393687
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01979235
85Sepsis (HP:0100806)2.01175151
86Inflammation of the large intestine (HP:0002037)2.00459125
87Eosinophilia (HP:0001880)1.99896789
88Chronic otitis media (HP:0000389)1.99334787
89Joint swelling (HP:0001386)1.98810753
90Encephalitis (HP:0002383)1.98387271
91Abnormality of the pericardium (HP:0001697)1.97923260
92Dysostosis multiplex (HP:0000943)1.97861080
93Xerostomia (HP:0000217)1.96529257
94Amaurosis fugax (HP:0100576)1.94432755
95Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93651707
96Fatigue (HP:0012378)1.93274801
97Epistaxis (HP:0000421)1.93156355
98Chromsome breakage (HP:0040012)1.91167549
99Glomerulonephritis (HP:0000099)1.90471547
100Menorrhagia (HP:0000132)1.89979651
101Lymphopenia (HP:0001888)1.89518020
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.88844108
103Interstitial pulmonary disease (HP:0006530)1.88487226
104Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88442812
105Bone pain (HP:0002653)1.88399623
106Prolonged bleeding time (HP:0003010)1.88130652
107Thrombophlebitis (HP:0004418)1.87503061
108Patchy hypopigmentation of hair (HP:0011365)1.87498651
109Alveolar cell carcinoma (HP:0006519)1.86135552
110Microcytic anemia (HP:0001935)1.85551653
111Absent/shortened dynein arms (HP:0200106)1.85253761
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.85253761
113Absent frontal sinuses (HP:0002688)1.85215438
114Peritonitis (HP:0002586)1.84924786
115Skin rash (HP:0000988)1.84486378
116Increased IgM level (HP:0003496)1.84053201
117Petechiae (HP:0000967)1.83510891
118Premature loss of primary teeth (HP:0006323)1.82037186
119Arterial thrombosis (HP:0004420)1.81644187
120Agammaglobulinemia (HP:0004432)1.78909954
121Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.77900345
122Aplasia cutis congenita (HP:0001057)1.76536629
123Keratitis (HP:0000491)1.75971202
124Recurrent corneal erosions (HP:0000495)1.75508450
125Pulmonary embolism (HP:0002204)1.74545360
126Colitis (HP:0002583)1.70446249
127Submucous cleft hard palate (HP:0000176)1.69649541
128Duplicated collecting system (HP:0000081)1.68668358
129Recurrent sinusitis (HP:0011108)1.67711311
130Gangrene (HP:0100758)1.65708208
131Gastrointestinal inflammation (HP:0004386)1.63266048
132Skin ulcer (HP:0200042)1.60904768
133Pulmonary artery stenosis (HP:0004415)1.60750945
134Agnosia (HP:0010524)1.59644590
135Prolonged neonatal jaundice (HP:0006579)1.59506351
136IgM deficiency (HP:0002850)1.59300060
137Septo-optic dysplasia (HP:0100842)1.59166780
138Glomerulopathy (HP:0100820)1.58550670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.76882918
2RIPK44.57635673
3IRAK44.06024074
4MAP3K143.31820143
5IRAK32.45913660
6FGR2.43635808
7TXK2.31365718
8MAP4K12.24562221
9FES2.17396133
10EPHB12.12003890
11CASK2.05149959
12CSK2.03946491
13KIT2.02119697
14CLK11.94554673
15PBK1.84286406
16TEC1.77043573
17TBK11.73362448
18YES11.63604646
19TYK21.62597354
20TESK21.60760856
21HCK1.57862860
22IKBKB1.57618011
23IKBKE1.57171070
24SIK21.52143488
25MAP3K131.51453119
26BTK1.51195382
27TAOK31.49106915
28BMPR21.44170114
29MAP3K31.42465211
30GRK71.37249661
31TAOK11.37175872
32SIK31.36777415
33MAP3K111.36463081
34LYN1.30922262
35TRPM71.24973466
36SYK1.24356168
37BCKDK1.21355905
38MAP2K21.11214686
39MARK31.05769575
40MAP3K121.05422748
41EIF2AK21.03737089
42ADRBK21.03019705
43STK101.01582633
44MST41.00887894
45GRK11.00113736
46LCK0.98925152
47JAK10.94630230
48CSF1R0.94454357
49TGFBR20.93670995
50MAP3K10.93638247
51ZAP700.91024108
52JAK30.90128117
53PKN10.87919988
54ITK0.86283409
55PDK10.84856118
56TAOK20.82523222
57MKNK20.80836463
58PRPF4B0.79955693
59PRKD20.78543978
60TNIK0.76878267
61IRAK10.75640790
62MAP2K30.75196161
63CAMK1D0.73145520
64INSRR0.72669492
65MARK20.68570100
66PRKCQ0.67238786
67MAP3K70.66537784
68ABL10.64768351
69KSR20.64247813
70CHUK0.64180219
71CAMK1G0.64130307
72PDPK10.63873632
73MATK0.63797177
74BMPR1B0.63305153
75KDR0.62911811
76NUAK10.61625380
77PRKCD0.61586558
78IRAK20.61016429
79PTK60.56210817
80TNK20.56101771
81ERBB30.55839801
82EPHA30.52602650
83MUSK0.51530529
84TLK10.50874839
85ABL20.50501084
86CDK90.49617267
87STK40.49611941
88PIK3CG0.48549757
89LRRK20.48155977
90NLK0.48021136
91* FYN0.47926049
92PIM10.46908765
93NEK60.46136263
94MAP3K60.43866751
95JAK20.43468071
96MAP3K50.42304917
97GRK60.42214326
98EGFR0.38928207
99DMPK0.38591941
100RPS6KA20.37548431
101PRKG20.37486492
102CDK190.36937881
103RPS6KA60.36687186
104RPS6KA10.34908597
105CDK60.34272820
106RPS6KC10.33128433
107RPS6KL10.33128433
108PIM20.33000192
109CDK40.32739471
110MAPK40.32491326
111DAPK20.32165901
112PRKG10.32046543
113ERN10.30700378
114RAF10.30566965
115MAPK70.30052170
116CDK30.29305056
117IGF1R0.27297969
118MAPK30.27214929
119MAPKAPK20.27069272
120PRKCE0.26821034
121PRKAA20.26651316
122NEK90.26142229
123STK110.26009197
124HIPK20.25773607
125CDC42BPA0.25650668
126PRKD10.25596131
127MKNK10.25427413
128MAP2K60.25106749
129INSR0.24203462
130MOS0.23717705
131SGK10.22673567
132MAPK130.22205103
133MAPK120.22054282
134SRC0.19296648

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.22170035
2Staphylococcus aureus infection_Homo sapiens_hsa051503.12202872
3Asthma_Homo sapiens_hsa053102.43688722
4Osteoclast differentiation_Homo sapiens_hsa043802.38654503
5Graft-versus-host disease_Homo sapiens_hsa053322.34416873
6Rheumatoid arthritis_Homo sapiens_hsa053232.33463113
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.31529957
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23219611
9Tuberculosis_Homo sapiens_hsa051522.19444070
10Malaria_Homo sapiens_hsa051442.09989546
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07776622
12Phagosome_Homo sapiens_hsa041451.98790793
13Hematopoietic cell lineage_Homo sapiens_hsa046401.98216242
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95454619
15Pertussis_Homo sapiens_hsa051331.92576116
16Lysosome_Homo sapiens_hsa041421.71676883
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71356424
18Other glycan degradation_Homo sapiens_hsa005111.68437222
19B cell receptor signaling pathway_Homo sapiens_hsa046621.66386120
20Allograft rejection_Homo sapiens_hsa053301.64800245
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59651148
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57497823
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57284959
24Salmonella infection_Homo sapiens_hsa051321.57271309
25Measles_Homo sapiens_hsa051621.57256052
26Legionellosis_Homo sapiens_hsa051341.56523120
27Chemokine signaling pathway_Homo sapiens_hsa040621.55853413
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53354959
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.51359683
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45907651
31TNF signaling pathway_Homo sapiens_hsa046681.45389286
32African trypanosomiasis_Homo sapiens_hsa051431.45387816
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.43946353
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32063169
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.29462481
36Collecting duct acid secretion_Homo sapiens_hsa049661.22231594
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.22069973
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21813767
39Influenza A_Homo sapiens_hsa051641.20383351
40Shigellosis_Homo sapiens_hsa051311.12983668
41Toxoplasmosis_Homo sapiens_hsa051451.11398155
42Autoimmune thyroid disease_Homo sapiens_hsa053201.07675040
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03715304
44Primary immunodeficiency_Homo sapiens_hsa053401.03113688
45Sphingolipid metabolism_Homo sapiens_hsa006001.02986345
46Type I diabetes mellitus_Homo sapiens_hsa049401.01611894
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99022149
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94110845
49Apoptosis_Homo sapiens_hsa042100.88492061
50Hepatitis B_Homo sapiens_hsa051610.87923848
51Herpes simplex infection_Homo sapiens_hsa051680.87596078
52Non-small cell lung cancer_Homo sapiens_hsa052230.86231856
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84760682
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84358618
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83761969
56T cell receptor signaling pathway_Homo sapiens_hsa046600.79927151
57Ether lipid metabolism_Homo sapiens_hsa005650.78517198
58Platelet activation_Homo sapiens_hsa046110.78094148
59Hepatitis C_Homo sapiens_hsa051600.77394694
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72919705
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.70798300
62Amoebiasis_Homo sapiens_hsa051460.70112200
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69105121
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67563213
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66578901
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66553494
67Mineral absorption_Homo sapiens_hsa049780.63768874
68Complement and coagulation cascades_Homo sapiens_hsa046100.63428207
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63086985
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.62451445
71Endocytosis_Homo sapiens_hsa041440.62134813
72Arachidonic acid metabolism_Homo sapiens_hsa005900.62126090
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61472726
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60729986
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58724605
76Serotonergic synapse_Homo sapiens_hsa047260.57943476
77Viral myocarditis_Homo sapiens_hsa054160.57077574
78Pancreatic cancer_Homo sapiens_hsa052120.55474646
79Acute myeloid leukemia_Homo sapiens_hsa052210.54766245
80Epstein-Barr virus infection_Homo sapiens_hsa051690.52872161
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50303439
82Steroid biosynthesis_Homo sapiens_hsa001000.49723736
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46977234
84Regulation of autophagy_Homo sapiens_hsa041400.46698260
85Histidine metabolism_Homo sapiens_hsa003400.46471449
86Morphine addiction_Homo sapiens_hsa050320.45714206
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44744919
88Chronic myeloid leukemia_Homo sapiens_hsa052200.43228789
89Viral carcinogenesis_Homo sapiens_hsa052030.41267521
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.40093735
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.39734009
92Melanoma_Homo sapiens_hsa052180.39021305
93Notch signaling pathway_Homo sapiens_hsa043300.37795041
94MAPK signaling pathway_Homo sapiens_hsa040100.37768106
95HTLV-I infection_Homo sapiens_hsa051660.36901517
96Ras signaling pathway_Homo sapiens_hsa040140.36660373
97Rap1 signaling pathway_Homo sapiens_hsa040150.36120754
98Type II diabetes mellitus_Homo sapiens_hsa049300.33461671
99Antigen processing and presentation_Homo sapiens_hsa046120.32257234
100Choline metabolism in cancer_Homo sapiens_hsa052310.31831960
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31686608
102Vibrio cholerae infection_Homo sapiens_hsa051100.30749971
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30543622
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29388256
105ABC transporters_Homo sapiens_hsa020100.28658730
106Insulin resistance_Homo sapiens_hsa049310.28234946
107Caffeine metabolism_Homo sapiens_hsa002320.28048346
108GnRH signaling pathway_Homo sapiens_hsa049120.26806572
109Dorso-ventral axis formation_Homo sapiens_hsa043200.25084519
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24185750
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23666058
112HIF-1 signaling pathway_Homo sapiens_hsa040660.23521647
113Prolactin signaling pathway_Homo sapiens_hsa049170.23409959
114mTOR signaling pathway_Homo sapiens_hsa041500.23280982
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.23279166
116Fanconi anemia pathway_Homo sapiens_hsa034600.23051107
117Calcium signaling pathway_Homo sapiens_hsa040200.22797264
118FoxO signaling pathway_Homo sapiens_hsa040680.22770292
119Long-term depression_Homo sapiens_hsa047300.22762475
120VEGF signaling pathway_Homo sapiens_hsa043700.22727727
121Inositol phosphate metabolism_Homo sapiens_hsa005620.20516650
122Renal cell carcinoma_Homo sapiens_hsa052110.19088976
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16463714
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14789307

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