CD28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.71596672
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.71596672
3positive regulation of gamma-delta T cell activation (GO:0046645)7.68404804
4* negative T cell selection (GO:0043383)7.65652486
5* negative thymic T cell selection (GO:0045060)6.89526022
6positive T cell selection (GO:0043368)6.89327354
7response to interleukin-15 (GO:0070672)6.85088092
8interferon-gamma production (GO:0032609)6.74436457
9positive thymic T cell selection (GO:0045059)6.74096313
10regulation of gamma-delta T cell differentiation (GO:0045586)6.64916805
11cellular response to interleukin-15 (GO:0071350)6.58669019
12tolerance induction (GO:0002507)6.58222342
13* positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.02056421
14* T cell selection (GO:0045058)6.01953755
15regulation of gamma-delta T cell activation (GO:0046643)6.00238964
16* thymic T cell selection (GO:0045061)5.87922491
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.76043651
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.72309408
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.72309408
20positive regulation of granulocyte differentiation (GO:0030854)5.60232665
21activated T cell proliferation (GO:0050798)5.33923088
22* regulation of isotype switching to IgG isotypes (GO:0048302)5.30834517
23* T cell receptor signaling pathway (GO:0050852)5.21690590
24regulation of B cell receptor signaling pathway (GO:0050855)5.13896823
25regulation of T cell tolerance induction (GO:0002664)5.13458302
26T cell migration (GO:0072678)5.09251163
27leukocyte aggregation (GO:0070486)5.01767847
28gonadal mesoderm development (GO:0007506)4.98488631
29positive regulation of natural killer cell mediated immunity (GO:0002717)4.97214849
30positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.97214849
31* T cell costimulation (GO:0031295)4.85767027
32* lymphocyte costimulation (GO:0031294)4.78510380
33* regulation of interleukin-2 biosynthetic process (GO:0045076)4.77858033
34regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.76845585
35regulation of natural killer cell mediated immunity (GO:0002715)4.76845585
36antigen processing and presentation of endogenous antigen (GO:0019883)4.74531075
37* antigen receptor-mediated signaling pathway (GO:0050851)4.37859630
38regulation of T cell receptor signaling pathway (GO:0050856)4.33855120
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.29779841
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.23706634
41* positive regulation of interleukin-2 production (GO:0032743)4.20033897
42positive regulation of tolerance induction (GO:0002645)4.18237937
43negative regulation of T cell mediated immunity (GO:0002710)3.96232075
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94907557
45positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.93539819
46regulation of regulatory T cell differentiation (GO:0045589)3.92642976
47regulation of leukocyte mediated cytotoxicity (GO:0001910)3.88336140
48positive regulation of T cell differentiation in thymus (GO:0033089)3.87585079
49* regulation of alpha-beta T cell proliferation (GO:0046640)3.85155320
50alpha-beta T cell differentiation (GO:0046632)3.81041741
51alpha-beta T cell activation (GO:0046631)3.78658422
52negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.68168538
53positive regulation of natural killer cell differentiation (GO:0032825)3.67405103
54positive regulation of B cell differentiation (GO:0045579)3.66486110
55CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.66207044
56regulation of granulocyte differentiation (GO:0030852)3.65640131
57regulation of T cell mediated cytotoxicity (GO:0001914)3.64978774
58regulation of interleukin-12 biosynthetic process (GO:0045075)3.64584424
59regulation of tolerance induction (GO:0002643)3.64385165
60positive regulation of cell killing (GO:0031343)3.62878409
61regulation of cell killing (GO:0031341)3.62505730
62mast cell activation (GO:0045576)3.59465967
63* T cell differentiation (GO:0030217)3.58500069
64negative regulation of T cell receptor signaling pathway (GO:0050860)3.53188960
65positive regulation of humoral immune response (GO:0002922)3.52101959
66positive regulation of T cell mediated cytotoxicity (GO:0001916)3.50091925
67mucosal-associated lymphoid tissue development (GO:0048537)3.44300835
68Peyers patch development (GO:0048541)3.44300835
69T cell proliferation (GO:0042098)3.42536435
70regulation of response to interferon-gamma (GO:0060330)3.41175563
71negative regulation of leukocyte mediated immunity (GO:0002704)3.40652327
72regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.40616447
73leukocyte cell-cell adhesion (GO:0007159)3.38166340
74* regulation of interleukin-2 production (GO:0032663)3.36415844
75* positive regulation of alpha-beta T cell proliferation (GO:0046641)3.34794325
76CD4-positive, alpha-beta T cell activation (GO:0035710)3.32028410
77* regulation of isotype switching (GO:0045191)3.29661658
78negative regulation of lymphocyte mediated immunity (GO:0002707)3.29393732
79regulation of B cell differentiation (GO:0045577)3.27657498
80negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.26458586
81* T cell activation (GO:0042110)3.25959531
82antigen processing and presentation via MHC class Ib (GO:0002475)3.23903767
83regulation of chronic inflammatory response (GO:0002676)3.23312994
84CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.23186217
85* positive regulation of isotype switching (GO:0045830)3.22963008
86positive regulation of interleukin-4 production (GO:0032753)3.22151266
87cellular response to type I interferon (GO:0071357)3.22149408
88type I interferon signaling pathway (GO:0060337)3.22149408
89T cell homeostasis (GO:0043029)3.21540558
90CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.21061392
91T-helper cell differentiation (GO:0042093)3.21061392
92response to type I interferon (GO:0034340)3.20913219
93lymphocyte migration (GO:0072676)3.17986703
94NIK/NF-kappaB signaling (GO:0038061)3.17425019
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.16253883
96negative regulation of T-helper cell differentiation (GO:0045623)3.16029087
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.16029087
98regulation of response to tumor cell (GO:0002834)3.13653728
99positive regulation of response to tumor cell (GO:0002836)3.13653728
100positive regulation of immune response to tumor cell (GO:0002839)3.13653728
101regulation of immune response to tumor cell (GO:0002837)3.13653728
102* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.12976110
103* regulation of immunoglobulin production (GO:0002637)3.10900078
104* regulation of alpha-beta T cell activation (GO:0046634)3.09480603
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09084141
106* regulation of immunoglobulin mediated immune response (GO:0002889)3.08479818
107negative regulation of adaptive immune response (GO:0002820)3.08304026
108* positive regulation of immunoglobulin mediated immune response (GO:0002891)3.06694345
109* positive regulation of B cell mediated immunity (GO:0002714)3.06694345
110* positive regulation of T cell activation (GO:0050870)3.06229596
111natural killer cell activation (GO:0030101)3.02623684
112T cell differentiation involved in immune response (GO:0002292)3.00988209
113alpha-beta T cell differentiation involved in immune response (GO:0002293)3.00988209
114alpha-beta T cell activation involved in immune response (GO:0002287)3.00988209
115JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00487238
116hepatocyte apoptotic process (GO:0097284)2.99725073
117regulation of interleukin-4 production (GO:0032673)2.99612505
118lymphocyte homeostasis (GO:0002260)2.99548303
119natural killer cell differentiation (GO:0001779)2.98820418
120* regulation of B cell mediated immunity (GO:0002712)2.98464615
121regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.98121833
122tyrosine phosphorylation of STAT protein (GO:0007260)2.98005447
123* positive regulation of lymphocyte mediated immunity (GO:0002708)2.97272426
124* regulation of lymphocyte mediated immunity (GO:0002706)2.96753187
125negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.96268013
126B cell receptor signaling pathway (GO:0050853)2.95562374
127heterotypic cell-cell adhesion (GO:0034113)2.95474837
128positive regulation of B cell proliferation (GO:0030890)2.94552156
129mast cell activation involved in immune response (GO:0002279)2.93249676
130mast cell degranulation (GO:0043303)2.93249676
131positive regulation of T cell differentiation (GO:0045582)2.93024407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.40698197
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.72628484
3E2F7_22180533_ChIP-Seq_HELA_Human4.23455393
4* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.06115919
5* RUNX_20019798_ChIP-Seq_JUKART_Human3.82759164
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.65281306
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.59924916
8* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.57030087
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.56761598
10MYB_26560356_Chip-Seq_TH2_Human3.39179944
11MYC_22102868_ChIP-Seq_BL_Human3.34656942
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.18145573
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12842364
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02770804
15* MAF_26560356_Chip-Seq_TH1_Human2.83930885
16MYB_26560356_Chip-Seq_TH1_Human2.80706290
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68214723
18UTX_26944678_Chip-Seq_JUKART_Human2.60033808
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57007608
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40468449
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.39524072
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.31077692
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.18411145
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10523630
25MAF_26560356_Chip-Seq_TH2_Human2.08566239
26VDR_21846776_ChIP-Seq_THP-1_Human2.07334112
27* GATA3_27048872_Chip-Seq_THYMUS_Human2.03667328
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02174319
29* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99771529
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.99752659
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99399753
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.95507259
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93045961
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92581629
35SPI1_23547873_ChIP-Seq_NB4_Human1.87759178
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85994431
37TCF7_22412390_ChIP-Seq_EML_Mouse1.83304841
38SCL_19346495_ChIP-Seq_HPC-7_Human1.68844791
39* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66142029
40VDR_24763502_ChIP-Seq_THP-1_Human1.62405564
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59704958
42* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59363234
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55784799
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51931399
45KDM2B_26808549_Chip-Seq_DND41_Human1.49035914
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46293623
47* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41790377
48SPI1_23127762_ChIP-Seq_K562_Human1.39535252
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35280221
50* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34701027
51* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33693222
52CIITA_25753668_ChIP-Seq_RAJI_Human1.29263849
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26681967
54* PU_27001747_Chip-Seq_BMDM_Mouse1.26620776
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.25290312
56VDR_23849224_ChIP-Seq_CD4+_Human1.22688572
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21980456
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20806635
59* GATA3_26560356_Chip-Seq_TH2_Human1.20280679
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16914380
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12801088
62FOXP3_21729870_ChIP-Seq_TREG_Human1.12272460
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11429441
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11088327
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10973445
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09679003
67ELK1_19687146_ChIP-ChIP_HELA_Human1.06092266
68GATA3_26560356_Chip-Seq_TH1_Human1.03733765
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.02157535
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.02020635
71* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98448101
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97970465
73ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97759806
74* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97494514
75* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96369187
76HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96177832
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95720134
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94490087
79ELK3_25401928_ChIP-Seq_HUVEC_Human0.92264686
80* FLI1_27457419_Chip-Seq_LIVER_Mouse0.91011572
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90935835
82SMRT_27268052_Chip-Seq_Bcells_Human0.89118854
83RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85331225
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85130221
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84920425
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81888215
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81816240
88* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81740018
89VDR_24787735_ChIP-Seq_THP-1_Human0.81615934
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81165108
91GATA1_19941826_ChIP-Seq_K562_Human0.80959046
92* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80259143
93GATA1_22025678_ChIP-Seq_K562_Human0.80186381
94* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79962875
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79156954
96* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78609672
97* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76240854
98NCOR1_26117541_ChIP-Seq_K562_Human0.73660986
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72764048
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.72308504
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72032709
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71894365
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71216354
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.70660593
105BCL6_27268052_Chip-Seq_Bcells_Human0.70265885
106* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70225198
107* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69476942
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.67987988
109P300_27268052_Chip-Seq_Bcells_Human0.67841072
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.66565917
111KDM5A_27292631_Chip-Seq_BREAST_Human0.64330203
112* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.63621745
113TFEB_21752829_ChIP-Seq_HELA_Human0.63375651
114* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.63314336
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.63186590
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62859410
117ETS1_22383799_ChIP-Seq_G1ME_Mouse0.62276563
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.61535214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003763_abnormal_thymus_physiology5.55151741
2* MP0005671_abnormal_response_to4.07974534
3MP0000685_abnormal_immune_system3.46527171
4* MP0001800_abnormal_humoral_immune3.19640240
5MP0005387_immune_system_phenotype3.17380160
6MP0001790_abnormal_immune_system3.17380160
7MP0002166_altered_tumor_susceptibility3.15121937
8MP0003436_decreased_susceptibility_to3.14053577
9* MP0005000_abnormal_immune_tolerance3.08156073
10MP0001835_abnormal_antigen_presentation3.02436442
11MP0006082_CNS_inflammation2.87773628
12* MP0002723_abnormal_immune_serum2.83254191
13* MP0002420_abnormal_adaptive_immunity2.82022341
14* MP0002398_abnormal_bone_marrow2.79749716
15MP0000703_abnormal_thymus_morphology2.78010265
16* MP0001819_abnormal_immune_cell2.77236665
17MP0002405_respiratory_system_inflammati2.75038772
18MP0009785_altered_susceptibility_to2.66299969
19MP0002006_tumorigenesis2.62183645
20* MP0002452_abnormal_antigen_presenting2.62010612
21* MP0009333_abnormal_splenocyte_physiolog2.61798759
22MP0003300_gastrointestinal_ulcer2.47609361
23* MP0000716_abnormal_immune_system2.44959802
24MP0002933_joint_inflammation2.43819767
25MP0002722_abnormal_immune_system2.36284003
26* MP0005025_abnormal_response_to2.35328265
27MP0010155_abnormal_intestine_physiology2.31352921
28* MP0000689_abnormal_spleen_morphology2.29138802
29MP0003866_abnormal_defecation2.22254097
30MP0004947_skin_inflammation2.21355755
31MP0001873_stomach_inflammation2.14911583
32MP0002396_abnormal_hematopoietic_system2.13494001
33MP0003724_increased_susceptibility_to2.00467480
34* MP0002429_abnormal_blood_cell2.00448047
35MP0002419_abnormal_innate_immunity1.89452369
36* MP0002148_abnormal_hypersensitivity_rea1.84692526
37MP0000858_altered_metastatic_potential1.81785531
38MP0003303_peritoneal_inflammation1.79398779
39* MP0001845_abnormal_inflammatory_respons1.71597302
40MP0005464_abnormal_platelet_physiology1.58598718
41MP0001853_heart_inflammation1.52249994
42MP0004381_abnormal_hair_follicle1.50414424
43MP0004510_myositis1.49874108
44MP0003448_altered_tumor_morphology1.49731808
45MP0004808_abnormal_hematopoietic_stem1.48530797
46MP0001533_abnormal_skeleton_physiology1.45136626
47MP0001348_abnormal_lacrimal_gland1.36349361
48MP0005310_abnormal_salivary_gland1.29547098
49MP0002009_preneoplasia1.25132781
50MP0000465_gastrointestinal_hemorrhage1.24839619
51MP0000490_abnormal_crypts_of1.15555421
52MP0001851_eye_inflammation1.14811361
53* MP0008469_abnormal_protein_level1.09658493
54MP0002019_abnormal_tumor_incidence1.09522153
55MP0005076_abnormal_cell_differentiation1.07904601
56MP0002998_abnormal_bone_remodeling1.06173628
57MP0010352_gastrointestinal_tract_polyps1.05373851
58MP0005075_abnormal_melanosome_morpholog1.03652579
59MP0008057_abnormal_DNA_replication1.03308003
60MP0005397_hematopoietic_system_phenotyp0.99442601
61MP0001545_abnormal_hematopoietic_system0.99442601
62MP0002163_abnormal_gland_morphology0.96790012
63MP0001919_abnormal_reproductive_system0.90457919
64MP0005451_abnormal_body_composition0.85473831
65MP0004130_abnormal_muscle_cell0.84902133
66MP0008007_abnormal_cellular_replicative0.83356773
67MP0002132_abnormal_respiratory_system0.80294576
68MP0005023_abnormal_wound_healing0.77518820
69MP0003077_abnormal_cell_cycle0.76685596
70MP0003828_pulmonary_edema0.75620391
71MP0005058_abnormal_lysosome_morphology0.75535183
72MP0010094_abnormal_chromosome_stability0.72879819
73* MP0002693_abnormal_pancreas_physiology0.72418965
74MP0003045_fibrosis0.71114371
75MP0002138_abnormal_hepatobiliary_system0.70871839
76MP0003172_abnormal_lysosome_physiology0.70259751
77MP0000604_amyloidosis0.68476328
78MP0008995_early_reproductive_senescence0.66893963
79MP0008961_abnormal_basal_metabolism0.66556811
80MP0009763_increased_sensitivity_to0.66118346
81MP0001243_abnormal_dermal_layer0.65895307
82MP0001986_abnormal_taste_sensitivity0.65799508
83MP0009764_decreased_sensitivity_to0.64493094
84MP0004883_abnormal_blood_vessel0.63938487
85MP0005174_abnormal_tail_pigmentation0.63742240
86MP0009278_abnormal_bone_marrow0.62429710
87MP0003795_abnormal_bone_structure0.61372291
88MP0003693_abnormal_embryo_hatching0.59882327
89MP0001765_abnormal_ion_homeostasis0.59701548
90MP0003786_premature_aging0.59069091
91MP0000609_abnormal_liver_physiology0.58913995
92MP0001191_abnormal_skin_condition0.58577767
93MP0005381_digestive/alimentary_phenotyp0.58259977
94MP0000477_abnormal_intestine_morphology0.57627987
95MP0009765_abnormal_xenobiotic_induced0.56932420
96MP0005390_skeleton_phenotype0.56551814
97MP0001881_abnormal_mammary_gland0.55849317
98MP0005379_endocrine/exocrine_gland_phen0.55781527
99MP0005166_decreased_susceptibility_to0.55398401
100MP0008877_abnormal_DNA_methylation0.53807564
101MP0002136_abnormal_kidney_physiology0.52674411
102MP0008260_abnormal_autophagy0.52138130
103MP0002928_abnormal_bile_duct0.50113343
104MP0000569_abnormal_digit_pigmentation0.50057332
105MP0001501_abnormal_sleep_pattern0.49138353
106MP0003787_abnormal_imprinting0.48270955
107MP0000015_abnormal_ear_pigmentation0.47798867
108MP0002277_abnormal_respiratory_mucosa0.47142291
109MP0003453_abnormal_keratinocyte_physiol0.46949964
110MP0000249_abnormal_blood_vessel0.46904614
111MP0000627_abnormal_mammary_gland0.46872247
112MP0008873_increased_physiological_sensi0.46324156
113MP0010307_abnormal_tumor_latency0.46278535
114MP0001663_abnormal_digestive_system0.45019352
115MP0000313_abnormal_cell_death0.43862689
116MP0004957_abnormal_blastocyst_morpholog0.43670816
117MP0003091_abnormal_cell_migration0.43455117
118MP0008569_lethality_at_weaning0.41455113
119MP0003252_abnormal_bile_duct0.40093081
120MP0003656_abnormal_erythrocyte_physiolo0.39665394
121MP0002083_premature_death0.39639396
122MP0009115_abnormal_fat_cell0.38610978

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.21577808
2Abnormality of T cell number (HP:0011839)7.81828053
3Severe combined immunodeficiency (HP:0004430)5.93941535
4Stomatitis (HP:0010280)5.71058734
5Abnormality of T cells (HP:0002843)5.50587344
6Combined immunodeficiency (HP:0005387)5.44162977
7Elevated erythrocyte sedimentation rate (HP:0003565)5.29451523
8Chronic diarrhea (HP:0002028)4.77045922
9Recurrent fungal infections (HP:0002841)4.73321918
10IgG deficiency (HP:0004315)4.63019667
11IgM deficiency (HP:0002850)4.59724817
12Recurrent bronchitis (HP:0002837)4.57240833
13Abnormality of B cell number (HP:0010975)4.44731747
14B lymphocytopenia (HP:0010976)4.44731747
15Recurrent viral infections (HP:0004429)4.43123734
16Myositis (HP:0100614)4.23673186
17Panhypogammaglobulinemia (HP:0003139)4.13598111
18Thyroiditis (HP:0100646)4.03006046
19Abnormality of eosinophils (HP:0001879)4.00141440
20Chronic mucocutaneous candidiasis (HP:0002728)3.95371723
21Recurrent cutaneous fungal infections (HP:0011370)3.95371723
22Eczematoid dermatitis (HP:0000976)3.85974090
23Abnormality of the fingertips (HP:0001211)3.69227391
24Eosinophilia (HP:0001880)3.68865154
25Retrobulbar optic neuritis (HP:0100654)3.56222602
26Optic neuritis (HP:0100653)3.56222602
27Joint swelling (HP:0001386)3.55535774
28Leukocytosis (HP:0001974)3.54694816
29Pustule (HP:0200039)3.51781555
30Increased IgM level (HP:0003496)3.49741565
31Gastrointestinal infarctions (HP:0005244)3.46703630
32Nasal polyposis (HP:0100582)3.46690285
33Chronic otitis media (HP:0000389)3.41842826
34IgA deficiency (HP:0002720)3.40268333
35Hemoptysis (HP:0002105)3.32666937
36Abnormality of T cell physiology (HP:0011840)3.25591597
37Pulmonary infiltrates (HP:0002113)3.15866634
38Hypoplasia of the thymus (HP:0000778)3.14243432
39Granulocytopenia (HP:0001913)3.10562729
40Orchitis (HP:0100796)3.07203668
41Mediastinal lymphadenopathy (HP:0100721)3.03590723
42Abnormality of the prostate (HP:0008775)3.01377769
43Vasculitis (HP:0002633)2.98584008
44Lymphopenia (HP:0001888)2.98445841
45Autoimmune hemolytic anemia (HP:0001890)2.98243159
46Meningitis (HP:0001287)2.97149902
47Gastrointestinal inflammation (HP:0004386)2.94742948
48Stomach cancer (HP:0012126)2.90990486
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.88599210
50Inflammation of the large intestine (HP:0002037)2.88160592
51Abnormality of macrophages (HP:0004311)2.85464541
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.85117070
53Prolonged bleeding time (HP:0003010)2.84982138
54Obstructive lung disease (HP:0006536)2.83889151
55Chronic obstructive pulmonary disease (HP:0006510)2.83889151
56Arterial thrombosis (HP:0004420)2.83382857
57Recurrent sinusitis (HP:0011108)2.79573213
58Abnormality of the nasal mucosa (HP:0000433)2.79273585
59Recurrent abscess formation (HP:0002722)2.76502975
60Lymphoma (HP:0002665)2.76481141
61Papilledema (HP:0001085)2.76477006
62Basal cell carcinoma (HP:0002671)2.60669657
63Ureteral stenosis (HP:0000071)2.60267514
64Keratoconjunctivitis sicca (HP:0001097)2.56925724
65Encephalitis (HP:0002383)2.54347598
66Autoimmune thrombocytopenia (HP:0001973)2.52271507
67Bronchitis (HP:0012387)2.46487569
68Acute hepatic failure (HP:0006554)2.46056980
69Ureteral obstruction (HP:0006000)2.45558399
70Recurrent skin infections (HP:0001581)2.44726156
71Amaurosis fugax (HP:0100576)2.42251856
72Pulmonary embolism (HP:0002204)2.41728167
73Cheilitis (HP:0100825)2.39611272
74Spontaneous hematomas (HP:0007420)2.35365449
75Hypochromic anemia (HP:0001931)2.33499903
76Hypergammaglobulinemia (HP:0010702)2.33364560
77Chest pain (HP:0100749)2.31359791
78Abnormality of binocular vision (HP:0011514)2.30405084
79Diplopia (HP:0000651)2.30405084
80Keratoconjunctivitis (HP:0001096)2.29877508
81Slow saccadic eye movements (HP:0000514)2.28671397
82Gangrene (HP:0100758)2.23550408
83Increased density of long bones (HP:0006392)2.09817777
84Urticaria (HP:0001025)2.09058813
85Thrombocytosis (HP:0001894)2.07087209
86Verrucae (HP:0200043)2.06346853
87Papilloma (HP:0012740)2.06346853
88Colitis (HP:0002583)2.04987292
89Epistaxis (HP:0000421)2.02636626
90Increased IgE level (HP:0003212)2.00599493
91Microcytic anemia (HP:0001935)2.00375137
92Gingivitis (HP:0000230)1.98545754
93Periodontitis (HP:0000704)1.97058599
94Anorexia (HP:0002039)1.96856875
95Abnormality of the pleura (HP:0002103)1.95257928
96Prostate neoplasm (HP:0100787)1.95222574
97Recurrent otitis media (HP:0000403)1.93474071
98Recurrent bacterial skin infections (HP:0005406)1.93426667
99Agammaglobulinemia (HP:0004432)1.92049882
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90395153
101Keratitis (HP:0000491)1.89605639
102Persistence of primary teeth (HP:0006335)1.89357082
103Hematochezia (HP:0002573)1.87072411
104Gastrointestinal stroma tumor (HP:0100723)1.86261722
105Abnormal platelet volume (HP:0011876)1.85688399
106Petechiae (HP:0000967)1.84868217
107Fatigue (HP:0012378)1.84585718
108Glomerulopathy (HP:0100820)1.84160043
109Alveolar cell carcinoma (HP:0006519)1.82110187
110Hypoproteinemia (HP:0003075)1.80473874
111Arthralgia (HP:0002829)1.78766074
112Neoplasm of the tracheobronchial system (HP:0100552)1.76945491
113Recurrent gram-negative bacterial infections (HP:0005420)1.76704887
114Polyneuropathy (HP:0001271)1.76553339
115Emphysema (HP:0002097)1.71985096
116Skin ulcer (HP:0200042)1.70936145
117Abnormality of the endocardium (HP:0004306)1.70649743
118Aplasia/Hypoplasia of the thymus (HP:0010515)1.70533851
119Gingival bleeding (HP:0000225)1.69874426
120Pulmonary fibrosis (HP:0002206)1.68865779
121Hepatitis (HP:0012115)1.68226527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.97635783
2MAP4K15.91629305
3JAK33.51003021
4ZAP703.17139205
5* ITK2.93182376
6FGFR42.72208554
7STK102.49507460
8IKBKE2.35218625
9RIPK42.33091039
10TYK22.31592540
11MAP3K142.28807100
12NLK2.26159637
13CAMKK22.22277336
14TEC2.17484382
15* LCK1.95422144
16JAK11.94586011
17GRK61.90418078
18FGFR31.86660773
19HCK1.62893891
20NME21.62090081
21CAMKK11.60021975
22CSK1.58564632
23BTK1.49650609
24SYK1.45640545
25TBK11.44031837
26MST41.42224160
27PRKCQ1.38969196
28EEF2K1.28559587
29MAP3K131.13092963
30IKBKB1.12708501
31CDK121.10474266
32SIK31.09766242
33KDR1.08387979
34BLK1.08016706
35TESK21.07782404
36IRAK41.01911908
37EPHA31.00312383
38EPHB10.98601855
39CLK10.98588214
40PRKCH0.98505339
41CHUK0.98099738
42MAP3K100.98081901
43PIM10.95579926
44JAK20.95287488
45LRRK20.88113079
46MARK30.86355004
47PKN20.85993050
48PIK3CG0.85594639
49KIT0.83891509
50SIK20.81803431
51TSSK60.81652299
52MELK0.77936985
53LYN0.76260407
54MAP3K70.76242730
55FES0.73143642
56PDGFRB0.72223196
57TNK20.69875562
58RPS6KA40.68565045
59TRIB30.67996981
60FRK0.67156478
61NUAK10.66409151
62TYRO30.66252327
63TGFBR20.65467397
64CDK60.63027588
65CDK40.61892153
66TAOK30.61468542
67MAP2K20.59119044
68TTN0.57552462
69MAP3K10.55701834
70ALK0.55245028
71TLK10.54375742
72ADRBK20.53257528
73MAPK70.51900415
74TAOK20.51778005
75ERN10.50731713
76STK40.48520578
77BRD40.47232980
78MAP2K30.47055664
79PDK10.46303430
80MAP3K30.45469266
81MAP2K60.45290282
82MAP3K110.44904779
83FGFR10.44620065
84FYN0.44518333
85HIPK20.43501446
86IRAK10.43300511
87CDC70.41945381
88INSR0.41913508
89CDK90.41685684
90CSF1R0.38870263
91DMPK0.38532326
92NEK90.38336538
93BMPR20.37406183
94CAMK40.36732858
95YES10.36138814
96NTRK20.35655782
97SCYL20.34828568
98SGK20.32949823
99FGR0.31685594
100MAPK120.31194882
101NEK60.30775323
102* IGF1R0.30735146
103EGFR0.30666377
104PTK60.30065117
105SGK30.29872539
106MAPK110.29688699
107MARK20.28727917
108RPS6KA50.26652773
109STK240.26313887
110IRAK20.26103855
111MAPK30.26006355
112RPS6KA60.25634307
113NEK20.24303898
114TAOK10.24115445
115MAPK40.23596409
116MAP3K80.23047672
117RAF10.22399084
118MAPKAPK20.21428201
119RPS6KC10.20375163
120TRPM70.19531143
121ABL10.19052577
122PRPF4B0.17105321
123IRAK30.17096815
124PASK0.16779551
125FGFR20.16338120

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.87535570
2* T cell receptor signaling pathway_Homo sapiens_hsa046604.11257546
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.91297642
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.15309787
5* Measles_Homo sapiens_hsa051622.84939853
6Antigen processing and presentation_Homo sapiens_hsa046122.73815387
7* Intestinal immune network for IgA production_Homo sapiens_hsa046722.63720866
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.63182341
9Hematopoietic cell lineage_Homo sapiens_hsa046402.26235775
10Osteoclast differentiation_Homo sapiens_hsa043802.06924293
11Jak-STAT signaling pathway_Homo sapiens_hsa046302.04783520
12Leishmaniasis_Homo sapiens_hsa051402.00305592
13* Allograft rejection_Homo sapiens_hsa053301.82868209
14B cell receptor signaling pathway_Homo sapiens_hsa046621.68656071
15* Graft-versus-host disease_Homo sapiens_hsa053321.66169281
16* Viral myocarditis_Homo sapiens_hsa054161.58371917
17Asthma_Homo sapiens_hsa053101.57735748
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53721882
19Herpes simplex infection_Homo sapiens_hsa051681.43452888
20* Autoimmune thyroid disease_Homo sapiens_hsa053201.42776364
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39192597
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38262262
23Toxoplasmosis_Homo sapiens_hsa051451.37400671
24Hepatitis B_Homo sapiens_hsa051611.36932103
25Chemokine signaling pathway_Homo sapiens_hsa040621.36772603
26Acute myeloid leukemia_Homo sapiens_hsa052211.36599547
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30396472
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.28386119
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28324204
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24851459
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24538006
32HTLV-I infection_Homo sapiens_hsa051661.20245778
33* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14330167
34Influenza A_Homo sapiens_hsa051641.14225817
35TNF signaling pathway_Homo sapiens_hsa046681.13865486
36Shigellosis_Homo sapiens_hsa051311.08973593
37Chronic myeloid leukemia_Homo sapiens_hsa052201.07062626
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06885843
39Staphylococcus aureus infection_Homo sapiens_hsa051501.04112390
40Pancreatic cancer_Homo sapiens_hsa052121.03857215
41Apoptosis_Homo sapiens_hsa042101.03318921
42Legionellosis_Homo sapiens_hsa051340.97117961
43Non-homologous end-joining_Homo sapiens_hsa034500.96701781
44Epstein-Barr virus infection_Homo sapiens_hsa051690.96090801
45Viral carcinogenesis_Homo sapiens_hsa052030.95447914
46Colorectal cancer_Homo sapiens_hsa052100.88778937
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87975765
48Malaria_Homo sapiens_hsa051440.86396688
49Prolactin signaling pathway_Homo sapiens_hsa049170.85379231
50Tuberculosis_Homo sapiens_hsa051520.82575969
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82552001
52VEGF signaling pathway_Homo sapiens_hsa043700.81808172
53Platelet activation_Homo sapiens_hsa046110.77241526
54Hepatitis C_Homo sapiens_hsa051600.76919451
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76381410
56Base excision repair_Homo sapiens_hsa034100.73756330
57p53 signaling pathway_Homo sapiens_hsa041150.69249272
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65210077
59Non-small cell lung cancer_Homo sapiens_hsa052230.64387170
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63717185
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62028426
62Mismatch repair_Homo sapiens_hsa034300.61333202
63Renal cell carcinoma_Homo sapiens_hsa052110.60276613
64Small cell lung cancer_Homo sapiens_hsa052220.59394630
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.59094058
66Pertussis_Homo sapiens_hsa051330.58812838
67Salmonella infection_Homo sapiens_hsa051320.58635242
68DNA replication_Homo sapiens_hsa030300.58495173
69Spliceosome_Homo sapiens_hsa030400.58433372
70Ribosome_Homo sapiens_hsa030100.58035880
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54878917
72Thyroid cancer_Homo sapiens_hsa052160.54413988
73RNA degradation_Homo sapiens_hsa030180.53287335
74* Rheumatoid arthritis_Homo sapiens_hsa053230.52543612
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52063533
76FoxO signaling pathway_Homo sapiens_hsa040680.52029666
77Prostate cancer_Homo sapiens_hsa052150.51866322
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49372562
79Notch signaling pathway_Homo sapiens_hsa043300.48524110
80Endocytosis_Homo sapiens_hsa041440.48390319
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47968299
82HIF-1 signaling pathway_Homo sapiens_hsa040660.47676467
83mTOR signaling pathway_Homo sapiens_hsa041500.45130682
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42775175
85Regulation of autophagy_Homo sapiens_hsa041400.42477112
86Circadian rhythm_Homo sapiens_hsa047100.41073044
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41057741
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39400473
89Endometrial cancer_Homo sapiens_hsa052130.39330772
90Linoleic acid metabolism_Homo sapiens_hsa005910.38404350
91African trypanosomiasis_Homo sapiens_hsa051430.38262805
92Ras signaling pathway_Homo sapiens_hsa040140.38054861
93MAPK signaling pathway_Homo sapiens_hsa040100.38034348
94Other glycan degradation_Homo sapiens_hsa005110.37754420
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.37341700
96mRNA surveillance pathway_Homo sapiens_hsa030150.36850212
97* Type I diabetes mellitus_Homo sapiens_hsa049400.36227784
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.35584598
99MicroRNAs in cancer_Homo sapiens_hsa052060.34257522
100Inositol phosphate metabolism_Homo sapiens_hsa005620.32915162
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.30479984
102RNA transport_Homo sapiens_hsa030130.29581254
103Type II diabetes mellitus_Homo sapiens_hsa049300.29375187
104Rap1 signaling pathway_Homo sapiens_hsa040150.29245184
105Adherens junction_Homo sapiens_hsa045200.27696611
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27022406
107Dorso-ventral axis formation_Homo sapiens_hsa043200.26942894
108Insulin resistance_Homo sapiens_hsa049310.26777975
109Choline metabolism in cancer_Homo sapiens_hsa052310.26455792
110Lysosome_Homo sapiens_hsa041420.24747291
111One carbon pool by folate_Homo sapiens_hsa006700.24418300
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.24379341
113Cell cycle_Homo sapiens_hsa041100.24327359
114Pathways in cancer_Homo sapiens_hsa052000.23449018
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22581126
116ErbB signaling pathway_Homo sapiens_hsa040120.22438486
117Long-term potentiation_Homo sapiens_hsa047200.22309957
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19690545
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19120222
120Glioma_Homo sapiens_hsa052140.18878763
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16902638

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