CD200R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.93586666
2negative regulation of cell killing (GO:0031342)6.93586666
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.93456790
4neutrophil activation involved in immune response (GO:0002283)6.04811675
5cellular response to interleukin-15 (GO:0071350)5.53844105
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.28845048
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.28845048
8modulation by symbiont of host immune response (GO:0052553)5.28845048
9positive regulation by symbiont of host defense response (GO:0052509)5.28845048
10modulation by symbiont of host defense response (GO:0052031)5.28845048
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.28845048
12response to interleukin-15 (GO:0070672)5.21740273
13tolerance induction (GO:0002507)4.98488712
14negative T cell selection (GO:0043383)4.88894108
15regulation of memory T cell differentiation (GO:0043380)4.81670402
16production of molecular mediator involved in inflammatory response (GO:0002532)4.74668781
17immunoglobulin mediated immune response (GO:0016064)4.73455802
18regulation of regulatory T cell differentiation (GO:0045589)4.68339315
19respiratory burst (GO:0045730)4.64926315
20regulation of interferon-beta biosynthetic process (GO:0045357)4.62279200
21response to peptidoglycan (GO:0032494)4.56313855
22negative thymic T cell selection (GO:0045060)4.52088074
23regulation of T cell mediated cytotoxicity (GO:0001914)4.48897902
24macrophage activation involved in immune response (GO:0002281)4.39357969
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.36426270
26regulation of gamma-delta T cell differentiation (GO:0045586)4.36223405
27positive regulation of interferon-alpha production (GO:0032727)4.35212054
28negative regulation of T cell mediated immunity (GO:0002710)4.26232972
29regulation of interferon-alpha production (GO:0032647)4.20471287
30cytidine catabolic process (GO:0006216)4.15868098
31cytidine deamination (GO:0009972)4.15868098
32cytidine metabolic process (GO:0046087)4.15868098
33antigen processing and presentation of endogenous antigen (GO:0019883)4.14985348
34regulation of B cell receptor signaling pathway (GO:0050855)4.12234881
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.11610117
36granulocyte activation (GO:0036230)4.08383232
37neutrophil activation (GO:0042119)4.04019142
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.03268956
39regulation of gamma-delta T cell activation (GO:0046643)4.02795661
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.97912709
41regulation of leukocyte mediated cytotoxicity (GO:0001910)3.97333871
42myeloid cell activation involved in immune response (GO:0002275)3.94790013
43regulation of activation of Janus kinase activity (GO:0010533)3.91558666
44positive thymic T cell selection (GO:0045059)3.91299044
45positive regulation of monocyte chemotaxis (GO:0090026)3.89911676
46positive regulation of gamma-delta T cell activation (GO:0046645)3.86128340
47positive regulation of T cell mediated cytotoxicity (GO:0001916)3.85692181
48positive regulation of mast cell activation (GO:0033005)3.84455218
49pyrimidine ribonucleoside catabolic process (GO:0046133)3.79126436
50dendritic cell chemotaxis (GO:0002407)3.78346679
51positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.76440164
52regulation of cell killing (GO:0031341)3.74464459
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73447459
54positive T cell selection (GO:0043368)3.72759048
55positive regulation of T cell differentiation in thymus (GO:0033089)3.70795270
56eosinophil migration (GO:0072677)3.66703404
57activated T cell proliferation (GO:0050798)3.66676029
58hydrogen peroxide biosynthetic process (GO:0050665)3.66538135
59positive regulation of mast cell activation involved in immune response (GO:0033008)3.64686204
60positive regulation of mast cell degranulation (GO:0043306)3.64686204
61negative regulation of lymphocyte mediated immunity (GO:0002707)3.62697182
62lymph node development (GO:0048535)3.61675271
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.60572094
64defense response to protozoan (GO:0042832)3.59994351
65regulation of mast cell degranulation (GO:0043304)3.59694679
66myeloid dendritic cell activation (GO:0001773)3.58948844
67superoxide anion generation (GO:0042554)3.56379996
68positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.55989713
69regulation of T cell receptor signaling pathway (GO:0050856)3.55662481
70regulation of natural killer cell mediated immunity (GO:0002715)3.53820693
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.53820693
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.53660410
73response to host immune response (GO:0052572)3.53660410
74positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.53650162
75response to muramyl dipeptide (GO:0032495)3.53357752
76mast cell activation (GO:0045576)3.53098254
77regulation of mast cell activation (GO:0033003)3.52410513
78regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.51689016
79leukocyte aggregation (GO:0070486)3.49648429
80thymic T cell selection (GO:0045061)3.49538236
81DNA deamination (GO:0045006)3.49292628
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.48876815
83B cell mediated immunity (GO:0019724)3.48369087
84myeloid dendritic cell differentiation (GO:0043011)3.48090290
85positive regulation of antigen processing and presentation (GO:0002579)3.46181636
86regulation of chronic inflammatory response (GO:0002676)3.44865109
87T-helper cell differentiation (GO:0042093)3.44827045
88CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.44827045
89cellular response to interferon-beta (GO:0035458)3.44676569
90positive regulation of defense response to virus by host (GO:0002230)3.43494793
91negative regulation of T cell apoptotic process (GO:0070233)3.39574823
92regulation of mast cell activation involved in immune response (GO:0033006)3.38465248
93reactive oxygen species biosynthetic process (GO:1903409)3.36941500
94regulation of T cell mediated immunity (GO:0002709)3.35575370
95T cell selection (GO:0045058)3.35487059
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35241020
97positive regulation of cell killing (GO:0031343)3.34221019
98antigen processing and presentation via MHC class Ib (GO:0002475)3.33728161
99positive regulation of B cell differentiation (GO:0045579)3.33676231
100positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.32746765
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.31503205
102negative regulation of T-helper cell differentiation (GO:0045623)3.31503205
103dendritic cell migration (GO:0036336)3.29986004
104response to interferon-beta (GO:0035456)3.27000519
105macrophage activation (GO:0042116)3.26944301
106negative regulation of adaptive immune response (GO:0002820)3.26481494
107positive regulation of natural killer cell mediated immunity (GO:0002717)3.26283736
108microglial cell activation (GO:0001774)3.26061424
109regulation of interleukin-12 biosynthetic process (GO:0045075)3.26051521
110positive regulation of cellular amide metabolic process (GO:0034250)3.25956952
111positive regulation of interferon-beta production (GO:0032728)3.24131252
112pinocytosis (GO:0006907)3.24108958
113positive regulation of chemokine biosynthetic process (GO:0045080)3.24077636
114response to protozoan (GO:0001562)3.22914103
115T cell migration (GO:0072678)3.22630089
116interferon-gamma-mediated signaling pathway (GO:0060333)3.22173157
117regulation of T cell chemotaxis (GO:0010819)3.21768828
118positive regulation of T cell chemotaxis (GO:0010820)3.21768828
119cellular extravasation (GO:0045123)3.21111298
120positive regulation of calcium-mediated signaling (GO:0050850)3.20261698
121cellular response to type I interferon (GO:0071357)3.19113723
122type I interferon signaling pathway (GO:0060337)3.19113723
123detection of molecule of bacterial origin (GO:0032490)3.18167750
124T cell differentiation involved in immune response (GO:0002292)3.17443157
125alpha-beta T cell differentiation involved in immune response (GO:0002293)3.17443157
126alpha-beta T cell activation involved in immune response (GO:0002287)3.17443157
127positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17042044
128myeloid leukocyte activation (GO:0002274)3.16667761
129response to type I interferon (GO:0034340)3.16414517
130regulation of T cell tolerance induction (GO:0002664)3.16251885
131positive regulation of T cell mediated immunity (GO:0002711)3.14216522
132actin nucleation (GO:0045010)3.13219968
133negative regulation of interleukin-17 production (GO:0032700)3.12987072
134response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11565256
135response to host (GO:0075136)3.11565256
136response to host defenses (GO:0052200)3.11565256
137negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11261807
138negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11110802
139negative regulation of leukocyte mediated immunity (GO:0002704)3.11068032
140regulation of B cell differentiation (GO:0045577)3.10347045
141positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08984331
142positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07823872
143regulation of germinal center formation (GO:0002634)3.07563431
144regulation of mononuclear cell migration (GO:0071675)3.07172037
145negative regulation of mast cell activation (GO:0033004)3.06081109
146Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05779173
147interferon-gamma production (GO:0032609)3.04521625
148eosinophil chemotaxis (GO:0048245)3.04498341
149mast cell activation involved in immune response (GO:0002279)3.03952008
150mast cell degranulation (GO:0043303)3.03952008
151lymphocyte chemotaxis (GO:0048247)3.02616877
152T cell costimulation (GO:0031295)3.01807185
153regulation of myeloid leukocyte mediated immunity (GO:0002886)3.01013061
154T cell receptor signaling pathway (GO:0050852)3.00004585
155positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.99197298
156positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.98741937
157regulation of monocyte chemotaxis (GO:0090025)2.98320867
158regulation of leukocyte degranulation (GO:0043300)2.98219769
159natural killer cell mediated cytotoxicity (GO:0042267)2.98116162
160natural killer cell mediated immunity (GO:0002228)2.98116162
161positive regulation of granulocyte differentiation (GO:0030854)2.98051142
162lymphocyte costimulation (GO:0031294)2.97515353
163regulation of interleukin-8 biosynthetic process (GO:0045414)2.96319656
164dendritic cell differentiation (GO:0097028)2.95336693
165regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.94335902
166cellular response to exogenous dsRNA (GO:0071360)2.92112810
167T-helper 1 type immune response (GO:0042088)2.92017792
168antigen receptor-mediated signaling pathway (GO:0050851)2.91699670
169regulation of antigen processing and presentation (GO:0002577)2.91490830
170positive regulation of interleukin-4 production (GO:0032753)2.91152168
171leukocyte mediated cytotoxicity (GO:0001909)2.90786926
172regulation of alpha-beta T cell proliferation (GO:0046640)2.90636252
173negative regulation of innate immune response (GO:0045824)2.88960687
174regulation of tolerance induction (GO:0002643)2.88703968
175regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88079236
176positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.87597801
177regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.87455012
178cellular response to thyroid hormone stimulus (GO:0097067)2.87312192
179regulation of chemokine biosynthetic process (GO:0045073)2.87136068
180positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.86463039
181neutrophil mediated immunity (GO:0002446)2.86395429
182positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86143422
183positive regulation of interleukin-10 production (GO:0032733)2.84032846
184regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.83757470
185mitotic cell cycle arrest (GO:0071850)2.82065420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.47039187
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.59398673
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.56538463
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.37959207
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.17368784
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.12204448
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.80705575
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.75907358
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72968384
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.58223807
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.55547914
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.20034155
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.12630479
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.87431530
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82898592
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.67095740
17SCL_19346495_ChIP-Seq_HPC-7_Human2.61177646
18SPI1_23547873_ChIP-Seq_NB4_Human2.57845861
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40204888
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40062699
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.38674955
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35238575
23BRD4_27068464_Chip-Seq_AML-cells_Mouse2.24884659
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20073042
25RUNX_20019798_ChIP-Seq_JUKART_Human2.08628879
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.02304904
27MYB_26560356_Chip-Seq_TH2_Human1.97807203
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.94189800
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87351560
30VDR_24763502_ChIP-Seq_THP-1_Human1.83616646
31PU_27001747_Chip-Seq_BMDM_Mouse1.82417244
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82368661
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81789934
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79658722
35CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.79491744
36SPI1_23127762_ChIP-Seq_K562_Human1.79049727
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78481273
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74156961
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72560058
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66611930
41MAF_26560356_Chip-Seq_TH1_Human1.64956809
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63198871
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59102015
44VDR_24787735_ChIP-Seq_THP-1_Human1.54763214
45MYB_26560356_Chip-Seq_TH1_Human1.53104860
46CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.52692117
47VDR_21846776_ChIP-Seq_THP-1_Human1.51862917
48VDR_22108803_ChIP-Seq_LS180_Human1.46736476
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44065731
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43262073
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43239010
52PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35464859
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.34738055
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33739250
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31480967
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30049910
57SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29570331
58GATA3_27048872_Chip-Seq_THYMUS_Human1.27969619
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25276194
60GATA3_26560356_Chip-Seq_TH2_Human1.24343260
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23168626
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21123681
63GATA1_22025678_ChIP-Seq_K562_Human1.20694926
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16918832
65UTX_26944678_Chip-Seq_JUKART_Human1.16490463
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.12772651
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10494778
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09001313
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07958959
70GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07358969
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06872328
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02081219
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01409380
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01236218
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00303383
76GATA3_26560356_Chip-Seq_TH1_Human0.98566741
77RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98115949
78STAT1_20625510_ChIP-Seq_HELA_Human0.97608327
79PRDM14_20953172_ChIP-Seq_ESCs_Human0.97540325
80* GATA1_19941827_ChIP-Seq_MEL_Mouse0.97130482
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95932262
82TCF7_22412390_ChIP-Seq_EML_Mouse0.95209180
83ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92502505
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92305125
85TFEB_21752829_ChIP-Seq_HELA_Human0.91503955
86TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90432347
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86975559
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86437852
89* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84160355
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84088224
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83826767
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.83335435
93MAF_26560356_Chip-Seq_TH2_Human0.82493608
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82307963
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.81702289
96SPI1_20517297_ChIP-Seq_HL60_Human0.78659496
97IRF1_19129219_ChIP-ChIP_H3396_Human0.76632920
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.76467796
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76110501
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74954592
101GATA3_21878914_ChIP-Seq_MCF-7_Human0.73578653
102ELF1_20517297_ChIP-Seq_JURKAT_Human0.72744257
103PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72017265
104P300_27268052_Chip-Seq_Bcells_Human0.71989201
105MYC_22102868_ChIP-Seq_BL_Human0.71678385
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71124107
107CIITA_25753668_ChIP-Seq_RAJI_Human0.70078094
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69996992
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69421301
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.69181838
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68539992
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67855685
113GATA2_19941826_ChIP-Seq_K562_Human0.67582292
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67366400
115EGR1_23403033_ChIP-Seq_LIVER_Mouse0.66681221
116P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.66646959
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.64394019
118GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63591432
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.63433908
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62099963
121EGR1_19032775_ChIP-ChIP_M12_Human0.61063565
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.60598851
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.60158953
124ETS1_22383799_ChIP-Seq_G1ME_Mouse0.59895637
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58370813
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58370813
127SOX2_20726797_ChIP-Seq_SW620_Human0.56039729
128SMRT_27268052_Chip-Seq_Bcells_Human0.55790903
129GATA1_19941826_ChIP-Seq_K562_Human0.55658727
130CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.55307940
131BCL6_27268052_Chip-Seq_Bcells_Human0.54144115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.90444407
2MP0003436_decreased_susceptibility_to4.13172634
3MP0002148_abnormal_hypersensitivity_rea3.74774931
4MP0009785_altered_susceptibility_to3.69647564
5MP0006082_CNS_inflammation3.41628080
6MP0002419_abnormal_innate_immunity3.35705212
7MP0005000_abnormal_immune_tolerance3.33761823
8MP0003303_peritoneal_inflammation3.14497705
9MP0005025_abnormal_response_to3.11945374
10MP0005058_abnormal_lysosome_morphology2.99129386
11* MP0005671_abnormal_response_to2.82445201
12* MP0002452_abnormal_antigen_presenting2.76832327
13MP0003724_increased_susceptibility_to2.73156873
14MP0000685_abnormal_immune_system2.66153780
15* MP0002723_abnormal_immune_serum2.61319337
16MP0001800_abnormal_humoral_immune2.61278036
17MP0005387_immune_system_phenotype2.58301048
18MP0001790_abnormal_immune_system2.58301048
19MP0002009_preneoplasia2.50596559
20MP0005464_abnormal_platelet_physiology2.49537188
21MP0002420_abnormal_adaptive_immunity2.42081991
22* MP0001819_abnormal_immune_cell2.41496852
23MP0001853_heart_inflammation2.20299822
24MP0004510_myositis2.18216877
25MP0002405_respiratory_system_inflammati2.15028165
26MP0003172_abnormal_lysosome_physiology2.06679315
27MP0001533_abnormal_skeleton_physiology1.97120283
28MP0001845_abnormal_inflammatory_respons1.95563651
29MP0010155_abnormal_intestine_physiology1.82744772
30MP0009764_decreased_sensitivity_to1.82682328
31MP0003191_abnormal_cellular_cholesterol1.80465936
32MP0000716_abnormal_immune_system1.77445170
33MP0000343_altered_response_to1.77261799
34MP0002398_abnormal_bone_marrow1.72456203
35MP0005174_abnormal_tail_pigmentation1.70876680
36MP0003075_altered_response_to1.69959680
37MP0003448_altered_tumor_morphology1.69319727
38MP0008469_abnormal_protein_level1.68610341
39MP0009333_abnormal_splenocyte_physiolog1.62476764
40MP0004947_skin_inflammation1.61419113
41MP0005310_abnormal_salivary_gland1.60604635
42MP0000569_abnormal_digit_pigmentation1.51692255
43MP0005166_decreased_susceptibility_to1.49280941
44MP0002998_abnormal_bone_remodeling1.49093143
45MP0004381_abnormal_hair_follicle1.48942165
46MP0000689_abnormal_spleen_morphology1.47188723
47MP0009840_abnormal_foam_cell1.46437715
48MP0000858_altered_metastatic_potential1.44399229
49MP0002429_abnormal_blood_cell1.43798428
50MP0003690_abnormal_glial_cell1.40273715
51MP0002006_tumorigenesis1.39463298
52MP0002722_abnormal_immune_system1.37788700
53MP0000465_gastrointestinal_hemorrhage1.29979148
54MP0000015_abnormal_ear_pigmentation1.26763197
55MP0005397_hematopoietic_system_phenotyp1.26544809
56MP0001545_abnormal_hematopoietic_system1.26544809
57MP0000604_amyloidosis1.25968823
58MP0003828_pulmonary_edema1.19768055
59MP0003763_abnormal_thymus_physiology1.17072370
60MP0001851_eye_inflammation1.14371743
61MP0003300_gastrointestinal_ulcer1.13694509
62MP0001986_abnormal_taste_sensitivity1.09427712
63MP0002933_joint_inflammation1.09364330
64MP0002166_altered_tumor_susceptibility1.07383347
65MP0003183_abnormal_peptide_metabolism1.00081922
66MP0004782_abnormal_surfactant_physiolog0.99951320
67MP0009278_abnormal_bone_marrow0.99593014
68MP0009763_increased_sensitivity_to0.96266396
69MP0002396_abnormal_hematopoietic_system0.95580869
70MP0003866_abnormal_defecation0.94658064
71MP0002876_abnormal_thyroid_physiology0.93119290
72MP0010307_abnormal_tumor_latency0.93083239
73MP0005390_skeleton_phenotype0.92469158
74MP0004808_abnormal_hematopoietic_stem0.92468596
75MP0001873_stomach_inflammation0.91161076
76MP0000490_abnormal_crypts_of0.90065613
77MP0005167_abnormal_blood-brain_barrier0.90034678
78MP0003878_abnormal_ear_physiology0.89837200
79MP0005377_hearing/vestibular/ear_phenot0.89837200
80MP0003656_abnormal_erythrocyte_physiolo0.89581921
81MP0001501_abnormal_sleep_pattern0.89143540
82MP0003186_abnormal_redox_activity0.87485428
83MP0000249_abnormal_blood_vessel0.86745684
84MP0001919_abnormal_reproductive_system0.85655556
85MP0004130_abnormal_muscle_cell0.84315055
86MP0005164_abnormal_response_to0.81909667
87MP0000371_diluted_coat_color0.80274782
88MP0002277_abnormal_respiratory_mucosa0.78958141
89MP0004147_increased_porphyrin_level0.78442870
90MP0003045_fibrosis0.78090208
91MP0003795_abnormal_bone_structure0.77912138
92MP0008260_abnormal_autophagy0.76376927
93MP0003806_abnormal_nucleotide_metabolis0.75984223
94MP0000703_abnormal_thymus_morphology0.74788069
95MP0001663_abnormal_digestive_system0.72763796
96MP0001765_abnormal_ion_homeostasis0.72050672
97MP0004883_abnormal_blood_vessel0.70280496
98MP0002102_abnormal_ear_morphology0.70277278
99MP0003638_abnormal_response/metabolism_0.70039116
100MP0002138_abnormal_hepatobiliary_system0.67814174
101MP0006054_spinal_hemorrhage0.66988539
102MP0004264_abnormal_extraembryonic_tissu0.66748547
103MP0000920_abnormal_myelination0.63453237
104MP0002254_reproductive_system_inflammat0.61872683
105MP0002132_abnormal_respiratory_system0.60823821
106MP0005647_abnormal_sex_gland0.59751883
107MP0002136_abnormal_kidney_physiology0.59558266
108MP0003566_abnormal_cell_adhesion0.58744603
109MP0002139_abnormal_hepatobiliary_system0.58528700
110MP0000372_irregular_coat_pigmentation0.58399112
111MP0008873_increased_physiological_sensi0.58357058
112MP0002693_abnormal_pancreas_physiology0.57231887
113MP0010329_abnormal_lipoprotein_level0.56462942
114MP0003011_delayed_dark_adaptation0.56228668
115MP0005075_abnormal_melanosome_morpholog0.54770792
116MP0002095_abnormal_skin_pigmentation0.53996145
117MP0008877_abnormal_DNA_methylation0.53725491
118MP0003279_aneurysm0.51316103
119MP0010386_abnormal_urinary_bladder0.51193592
120MP0010352_gastrointestinal_tract_polyps0.48815483
121MP0009765_abnormal_xenobiotic_induced0.46432631
122MP0002019_abnormal_tumor_incidence0.46215097
123MP0005076_abnormal_cell_differentiation0.44736977

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.71331363
2Recurrent bacterial skin infections (HP:0005406)7.17902151
3Eczematoid dermatitis (HP:0000976)7.12441006
4Recurrent gram-negative bacterial infections (HP:0005420)6.24437901
5Abnormality of macrophages (HP:0004311)5.37761140
6IgG deficiency (HP:0004315)5.34646933
7Vacuolated lymphocytes (HP:0001922)5.14160659
8Myositis (HP:0100614)4.58717263
9Recurrent skin infections (HP:0001581)4.57906559
10Mediastinal lymphadenopathy (HP:0100721)4.53886035
11Severe combined immunodeficiency (HP:0004430)4.35290985
12Increased cerebral lipofuscin (HP:0011813)4.33584812
13Elevated erythrocyte sedimentation rate (HP:0003565)4.23118523
14Orchitis (HP:0100796)4.22036811
15Stomach cancer (HP:0012126)4.13209964
16Recurrent fungal infections (HP:0002841)4.10632574
17Retrobulbar optic neuritis (HP:0100654)4.09051529
18Optic neuritis (HP:0100653)4.09051529
19Increased neuronal autofluorescent lipopigment (HP:0002074)4.07548001
20Chronic obstructive pulmonary disease (HP:0006510)4.05641600
21Obstructive lung disease (HP:0006536)4.05641600
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.01383038
23Gingivitis (HP:0000230)3.92262826
24Systemic lupus erythematosus (HP:0002725)3.91157361
25Disinhibition (HP:0000734)3.83255966
26Agnosia (HP:0010524)3.81572270
27Abnormality of T cell physiology (HP:0011840)3.78966309
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.52578182
29Abnormality of glycolipid metabolism (HP:0010969)3.49485614
30Abnormality of liposaccharide metabolism (HP:0010968)3.49485614
31Abnormality of glycosphingolipid metabolism (HP:0004343)3.49485614
32Combined immunodeficiency (HP:0005387)3.47467027
33Prostate neoplasm (HP:0100787)3.35078567
34Axonal loss (HP:0003447)3.33985292
35Autoimmune thrombocytopenia (HP:0001973)3.31702028
36Chronic mucocutaneous candidiasis (HP:0002728)3.28640596
37Recurrent cutaneous fungal infections (HP:0011370)3.28640596
38Recurrent bronchitis (HP:0002837)3.27590143
39Stomatitis (HP:0010280)3.26783911
40Chronic diarrhea (HP:0002028)3.20814977
41Recurrent viral infections (HP:0004429)3.20364013
42Dysostosis multiplex (HP:0000943)3.15564431
43Cellulitis (HP:0100658)3.06000851
44Abnormality of B cell number (HP:0010975)3.04535495
45Vasculitis (HP:0002633)3.02888030
46Petechiae (HP:0000967)3.00689736
47Granulocytopenia (HP:0001913)2.88611856
48Meningitis (HP:0001287)2.84903257
49Basal ganglia calcification (HP:0002135)2.82394325
50Glomerulonephritis (HP:0000099)2.77867135
51Pulmonary infiltrates (HP:0002113)2.74777023
52Urticaria (HP:0001025)2.72057073
53Periodontitis (HP:0000704)2.71832576
54Hepatosplenomegaly (HP:0001433)2.71524529
55Abnormality of the prostate (HP:0008775)2.70501687
56Interstitial pulmonary disease (HP:0006530)2.68007476
57Arterial thrombosis (HP:0004420)2.65177039
58Pustule (HP:0200039)2.64196604
59Abnormality of male internal genitalia (HP:0000022)2.58707281
60Leukocytosis (HP:0001974)2.56645469
61Keratoconjunctivitis sicca (HP:0001097)2.55507575
62Mucopolysacchariduria (HP:0008155)2.53175075
63Urinary glycosaminoglycan excretion (HP:0003541)2.53175075
64Recurrent pneumonia (HP:0006532)2.51314347
65Hemoptysis (HP:0002105)2.50367413
66Pulmonary embolism (HP:0002204)2.48730187
67Autoimmune hemolytic anemia (HP:0001890)2.47589890
68B lymphocytopenia (HP:0010976)2.45099409
69Osteomyelitis (HP:0002754)2.42834380
70Pulmonary fibrosis (HP:0002206)2.42371019
71Glomerulopathy (HP:0100820)2.39652841
72Gingival bleeding (HP:0000225)2.37415036
73Abnormality of polysaccharide metabolism (HP:0011012)2.36255831
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36255831
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36255831
76Conical tooth (HP:0000698)2.35418998
77Anhidrosis (HP:0000970)2.34172088
78IgA deficiency (HP:0002720)2.31822891
79Chest pain (HP:0100749)2.31767538
80Keratoconjunctivitis (HP:0001096)2.30471456
81Epistaxis (HP:0000421)2.28164264
82Upper motor neuron abnormality (HP:0002127)2.28054758
83Prolonged bleeding time (HP:0003010)2.27798756
84Poor head control (HP:0002421)2.27686259
85Joint swelling (HP:0001386)2.26716154
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26616566
87Thrombocytosis (HP:0001894)2.25291101
88IgM deficiency (HP:0002850)2.24605801
89Albinism (HP:0001022)2.22544348
90Thick nail (HP:0001805)2.22280817
91Panhypogammaglobulinemia (HP:0003139)2.20155119
92Myocardial infarction (HP:0001658)2.17982139
93Joint hemorrhage (HP:0005261)2.17021177
94Recurrent lower respiratory tract infections (HP:0002783)2.15764976
95Renal cortical cysts (HP:0000803)2.14512493
96Loss of speech (HP:0002371)2.13366597
97Inflammation of the large intestine (HP:0002037)2.10283181
98Spinal cord lesions (HP:0100561)2.08987899
99Syringomyelia (HP:0003396)2.08987899
100Anorexia (HP:0002039)2.08505719
101Abnormality of T cell number (HP:0011839)2.04383336
102Chronic otitis media (HP:0000389)2.03706751
103Purpura (HP:0000979)2.02304138
104Bronchitis (HP:0012387)2.01287791
105Increased IgM level (HP:0003496)2.00523676
106Thyroiditis (HP:0100646)1.98911097
107Spontaneous hematomas (HP:0007420)1.98539879
108Lymphopenia (HP:0001888)1.97785213
109Hypergammaglobulinemia (HP:0010702)1.97613898
110Keratitis (HP:0000491)1.97468100
111Diminished motivation (HP:0000745)1.97166208
112T lymphocytopenia (HP:0005403)1.96429815
113Metaphyseal dysplasia (HP:0100255)1.95993003
114Abnormality of cells of the lymphoid lineage (HP:0012140)1.95188376
115Inappropriate behavior (HP:0000719)1.94835805
116Gastrointestinal inflammation (HP:0004386)1.94283181
117Vertigo (HP:0002321)1.93933638
118Porencephaly (HP:0002132)1.93236752
119Abnormality of the pleura (HP:0002103)1.93094946
120Hematochezia (HP:0002573)1.92326679
121Sepsis (HP:0100806)1.92109799
122Beaking of vertebral bodies (HP:0004568)1.91608271
123Agammaglobulinemia (HP:0004432)1.90487552
124Gastrointestinal infarctions (HP:0005244)1.90103168
125Gangrene (HP:0100758)1.88982535
126Cheilitis (HP:0100825)1.88809303
127Eosinophilia (HP:0001880)1.88348067
128Encephalitis (HP:0002383)1.88074463
129Methylmalonic acidemia (HP:0002912)1.87540004
130Spondylolisthesis (HP:0003302)1.85927638
131Personality changes (HP:0000751)1.85589820
132Gastrointestinal stroma tumor (HP:0100723)1.85411876
133Abnormality of the pericardium (HP:0001697)1.84390256
134Nephritis (HP:0000123)1.83751759
135Arthralgia (HP:0002829)1.83461329
136Polyneuropathy (HP:0001271)1.83213521
137Abnormality of T cells (HP:0002843)1.82759521
138Recurrent sinusitis (HP:0011108)1.82572892
139Growth hormone excess (HP:0000845)1.82261353
140Abnormality of eosinophils (HP:0001879)1.82041920
141Pancreatitis (HP:0001733)1.81709819
142Neutropenia (HP:0001875)1.77776479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.35995547
2BLK4.21417333
3MAP3K143.77038582
4MAP4K13.52916489
5TXK3.35618391
6IRAK33.11501874
7TBK13.09653986
8MAP2K23.01524349
9IRAK42.94999301
10TYK22.83800400
11KIT2.81532260
12TESK22.57066737
13JAK32.34785584
14IKBKB2.30655509
15PBK2.27445245
16MAP3K92.23692736
17NME22.12513765
18PIM22.03023150
19IKBKE1.99088178
20ZAP701.91935081
21TEC1.81194029
22BTK1.79636816
23SYK1.74741209
24JAK11.74032875
25CSF1R1.66571616
26ERN11.59785527
27TLK11.58077827
28NEK91.54584404
29TAOK31.49888159
30TGFBR21.47952026
31HCK1.42949174
32LYN1.41093492
33CLK11.39872872
34LCK1.35252133
35CSK1.30473767
36STK101.25973281
37FES1.20719924
38MATK1.20698709
39JAK21.20456117
40MAP4K21.17875030
41FGR1.17393082
42ABL21.16339452
43PIM11.15449180
44CHUK1.12892025
45GRK71.12535828
46BMPR21.10898214
47ITK1.04384901
48MAP2K31.04224615
49MAP3K131.01328508
50MAPK70.91373066
51ARAF0.89555970
52TRPM70.87033891
53BMX0.85901542
54EPHB10.85547699
55ADRBK20.84306840
56YES10.84217832
57MAP3K120.82641660
58ZAK0.79780849
59MARK30.79725753
60MST40.76652781
61STK40.76437806
62RPS6KA40.74338032
63PRKCD0.73218121
64MAP2K10.70159810
65GRK10.66352425
66FGFR30.65731528
67EIF2AK20.65110594
68ABL10.63043076
69SIK30.63033476
70ERBB30.61860209
71BMPR1B0.61455027
72FLT30.60517036
73PIK3CA0.60133133
74LRRK20.59330815
75SCYL20.59001846
76RAF10.56178702
77PINK10.55977608
78BCKDK0.54842919
79CDK60.54743928
80EPHA30.54613081
81KSR20.54409347
82FRK0.53658499
83SIK20.52749628
84EGFR0.52457693
85PTK2B0.52312245
86PDK10.46366376
87PRKCQ0.46064186
88ACVR1B0.45979562
89MAP3K110.45116153
90IRAK10.44728813
91FGFR40.44245020
92DYRK30.43796464
93MAPKAPK20.43366254
94TGFBR10.41259527
95ERBB20.40974763
96DAPK20.40768977
97MAP3K50.40220222
98MAP3K100.40130925
99GRK60.39824315
100RIPK10.39404392
101RPS6KA60.38270613
102FYN0.37321075
103NUAK10.37225884
104PIK3CG0.35783088
105RPS6KA20.33718876
106CAMKK20.31429455
107PDGFRB0.31376034
108IGF1R0.31320348
109NLK0.29568189
110MOS0.29005040
111MAP2K60.28621201
112INSR0.28059857
113HIPK20.26317166
114PDPK10.26230989
115MAPK120.25910162
116GRK50.25433068
117RPS6KL10.25350853
118RPS6KC10.25350853
119IRAK20.25108504
120MAPK40.25102777
121PRKG20.24718282
122PKN20.24670827
123CDK40.24544269
124TAOK20.24390208
125MAPKAPK30.23207699
126ADRBK10.23099294
127TNK20.22600118
128MAPK110.21424280
129MST1R0.20177639
130DYRK1B0.19983701
131KDR0.19876258
132MAP3K10.19363712
133MAPK30.18030764

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.48465153
2Graft-versus-host disease_Homo sapiens_hsa053323.17475057
3Staphylococcus aureus infection_Homo sapiens_hsa051503.00208128
4Osteoclast differentiation_Homo sapiens_hsa043802.51005561
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.50987929
6Legionellosis_Homo sapiens_hsa051342.49406202
7Tuberculosis_Homo sapiens_hsa051522.45290886
8Lysosome_Homo sapiens_hsa041422.45015593
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.44198083
10Allograft rejection_Homo sapiens_hsa053302.42592868
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.40959575
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37344342
13Rheumatoid arthritis_Homo sapiens_hsa053232.35384129
14Asthma_Homo sapiens_hsa053102.30535420
15Pertussis_Homo sapiens_hsa051332.30366831
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08833691
17Malaria_Homo sapiens_hsa051442.08576896
18Measles_Homo sapiens_hsa051622.08242715
19Phagosome_Homo sapiens_hsa041452.07048766
20Other glycan degradation_Homo sapiens_hsa005112.02313229
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.92065452
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92047057
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.91147879
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82488773
25Hematopoietic cell lineage_Homo sapiens_hsa046401.80960529
26Salmonella infection_Homo sapiens_hsa051321.78827209
27B cell receptor signaling pathway_Homo sapiens_hsa046621.65336489
28Primary immunodeficiency_Homo sapiens_hsa053401.54249508
29Influenza A_Homo sapiens_hsa051641.53738929
30Type I diabetes mellitus_Homo sapiens_hsa049401.53219212
31Antigen processing and presentation_Homo sapiens_hsa046121.49811736
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47737504
33TNF signaling pathway_Homo sapiens_hsa046681.47120009
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47002235
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.45629311
36Toxoplasmosis_Homo sapiens_hsa051451.38772520
37Chemokine signaling pathway_Homo sapiens_hsa040621.38417948
38Herpes simplex infection_Homo sapiens_hsa051681.34288094
39Autoimmune thyroid disease_Homo sapiens_hsa053201.33437532
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32708104
41Shigellosis_Homo sapiens_hsa051311.29802479
42Apoptosis_Homo sapiens_hsa042101.29418106
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23321510
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22311863
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20645721
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11943844
47Caffeine metabolism_Homo sapiens_hsa002321.07998186
48African trypanosomiasis_Homo sapiens_hsa051431.06688972
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05150888
50Viral myocarditis_Homo sapiens_hsa054161.04683630
51Collecting duct acid secretion_Homo sapiens_hsa049661.03379328
52T cell receptor signaling pathway_Homo sapiens_hsa046601.02898227
53Hepatitis B_Homo sapiens_hsa051611.00161066
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92322932
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.89253634
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88527610
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85728445
58Platelet activation_Homo sapiens_hsa046110.85217525
59Hepatitis C_Homo sapiens_hsa051600.84498364
60Complement and coagulation cascades_Homo sapiens_hsa046100.80280931
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79667085
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79588919
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77831793
64Acute myeloid leukemia_Homo sapiens_hsa052210.71965999
65Amoebiasis_Homo sapiens_hsa051460.69893075
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67903152
67Renin-angiotensin system_Homo sapiens_hsa046140.61359526
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61241159
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58800373
70Linoleic acid metabolism_Homo sapiens_hsa005910.56308744
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55979733
72Dorso-ventral axis formation_Homo sapiens_hsa043200.51938348
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51756111
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.51074907
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49742761
76Steroid biosynthesis_Homo sapiens_hsa001000.47384510
77Epstein-Barr virus infection_Homo sapiens_hsa051690.47349727
78Prolactin signaling pathway_Homo sapiens_hsa049170.46735576
79Chronic myeloid leukemia_Homo sapiens_hsa052200.46298207
80Renin secretion_Homo sapiens_hsa049240.46162647
81Pancreatic cancer_Homo sapiens_hsa052120.45125681
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40530759
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39657566
84Prion diseases_Homo sapiens_hsa050200.38855146
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.38829622
86Sphingolipid metabolism_Homo sapiens_hsa006000.37763287
87Vibrio cholerae infection_Homo sapiens_hsa051100.37424337
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.35628177
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34451458
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34167387
91Morphine addiction_Homo sapiens_hsa050320.32748024
92Circadian rhythm_Homo sapiens_hsa047100.31341372
93HIF-1 signaling pathway_Homo sapiens_hsa040660.31180985
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28643243
95Endocytosis_Homo sapiens_hsa041440.28154258
96Viral carcinogenesis_Homo sapiens_hsa052030.26991099
97Serotonergic synapse_Homo sapiens_hsa047260.23575574
98MAPK signaling pathway_Homo sapiens_hsa040100.23445864
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23016261
100Phototransduction_Homo sapiens_hsa047440.22930911
101FoxO signaling pathway_Homo sapiens_hsa040680.21673953
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21471325
103Nitrogen metabolism_Homo sapiens_hsa009100.20695800
104HTLV-I infection_Homo sapiens_hsa051660.17107018
105VEGF signaling pathway_Homo sapiens_hsa043700.16989856
106Tryptophan metabolism_Homo sapiens_hsa003800.14434230
107Mineral absorption_Homo sapiens_hsa049780.13992925
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13365384
109Arachidonic acid metabolism_Homo sapiens_hsa005900.11904769
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.11465029
111Insulin resistance_Homo sapiens_hsa049310.11453920
112Cholinergic synapse_Homo sapiens_hsa047250.11425936
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.10155247
114ABC transporters_Homo sapiens_hsa020100.09180192
115Proteoglycans in cancer_Homo sapiens_hsa052050.09064239
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.08762145
117Regulation of autophagy_Homo sapiens_hsa041400.06565459
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06214542
119cAMP signaling pathway_Homo sapiens_hsa040240.06182156
120Non-homologous end-joining_Homo sapiens_hsa034500.06154648
121Small cell lung cancer_Homo sapiens_hsa052220.05136927
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04587345
123p53 signaling pathway_Homo sapiens_hsa041150.03726184
124Galactose metabolism_Homo sapiens_hsa000520.02868792
125Non-small cell lung cancer_Homo sapiens_hsa052230.02357780

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