CD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)9.08426654
2cytidine metabolic process (GO:0046087)9.08426654
3cytidine catabolic process (GO:0006216)9.08426654
4negative T cell selection (GO:0043383)8.39184272
5positive regulation of gamma-delta T cell activation (GO:0046645)8.28711652
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.24053393
7negative thymic T cell selection (GO:0045060)8.24036884
8positive thymic T cell selection (GO:0045059)8.07377893
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.63441439
10thymic T cell selection (GO:0045061)7.45454830
11DNA deamination (GO:0045006)7.34598833
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.24126274
13positive T cell selection (GO:0043368)7.23333658
14regulation of gamma-delta T cell differentiation (GO:0045586)6.85259866
15T cell selection (GO:0045058)6.79286970
16regulation of isotype switching to IgG isotypes (GO:0048302)6.55881348
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.28059896
18negative regulation of cell killing (GO:0031342)6.28059896
19cellular response to interleukin-15 (GO:0071350)6.26602890
20regulation of gamma-delta T cell activation (GO:0046643)6.18220421
21response to interleukin-15 (GO:0070672)6.15073875
22regulation of T cell tolerance induction (GO:0002664)6.14545416
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.04236199
24interferon-gamma production (GO:0032609)6.00754141
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95853652
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.95853652
27T cell costimulation (GO:0031295)5.81159894
28T cell receptor signaling pathway (GO:0050852)5.81044494
29lymphocyte costimulation (GO:0031294)5.71773055
30leukocyte aggregation (GO:0070486)5.67772618
31T cell migration (GO:0072678)5.50018966
32antigen processing and presentation of endogenous antigen (GO:0019883)5.36340555
33sequestering of actin monomers (GO:0042989)5.29939490
34positive regulation of tolerance induction (GO:0002645)5.04810253
35antigen receptor-mediated signaling pathway (GO:0050851)5.02665886
36regulation of B cell receptor signaling pathway (GO:0050855)4.83487001
37regulation of T cell receptor signaling pathway (GO:0050856)4.82006184
38regulation of alpha-beta T cell proliferation (GO:0046640)4.67354594
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.64432585
40regulation of activation of Janus kinase activity (GO:0010533)4.60409311
41regulation of interleukin-2 biosynthetic process (GO:0045076)4.60108549
42positive regulation of alpha-beta T cell proliferation (GO:0046641)4.48957779
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.45482976
44negative regulation by host of viral transcription (GO:0043922)4.44713236
45regulation of tolerance induction (GO:0002643)4.43791543
46tolerance induction (GO:0002507)4.43236435
47regulation of chronic inflammatory response (GO:0002676)4.39663466
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.37313744
49negative regulation of T cell apoptotic process (GO:0070233)4.34870331
50regulation of lymphocyte chemotaxis (GO:1901623)4.34653163
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.22356667
52positive regulation of T cell mediated cytotoxicity (GO:0001916)4.18409260
53positive regulation of interleukin-2 production (GO:0032743)4.11459494
54positive regulation of natural killer cell mediated immunity (GO:0002717)4.09868676
55positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.09868676
56regulation of natural killer cell mediated immunity (GO:0002715)4.08643661
57regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.08643661
58regulation of T cell mediated cytotoxicity (GO:0001914)4.08318895
59negative regulation of viral genome replication (GO:0045071)4.04059556
60mast cell activation (GO:0045576)4.03153144
61eosinophil chemotaxis (GO:0048245)3.99151724
62positive regulation of isotype switching (GO:0045830)3.98993746
63positive regulation of calcium-mediated signaling (GO:0050850)3.96166412
64regulation of interleukin-12 biosynthetic process (GO:0045075)3.94259926
65pyrimidine nucleoside catabolic process (GO:0046135)3.93715443
66activated T cell proliferation (GO:0050798)3.89387301
67positive regulation of T cell chemotaxis (GO:0010820)3.89169663
68regulation of T cell chemotaxis (GO:0010819)3.89169663
69positive regulation of defense response to virus by host (GO:0002230)3.89106412
70regulation of response to interferon-gamma (GO:0060330)3.88770928
71positive regulation of lymphocyte migration (GO:2000403)3.87352439
72regulation of isotype switching (GO:0045191)3.87247345
73regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.84985343
74regulation of regulatory T cell differentiation (GO:0045589)3.77076049
75positive regulation of humoral immune response (GO:0002922)3.76587095
76B cell receptor signaling pathway (GO:0050853)3.74524808
77lymphocyte chemotaxis (GO:0048247)3.74505080
78positive regulation of B cell differentiation (GO:0045579)3.72214700
79regulation of defense response to virus by virus (GO:0050690)3.71248406
80regulation of type I interferon-mediated signaling pathway (GO:0060338)3.67898079
81positive regulation of immunoglobulin mediated immune response (GO:0002891)3.66345468
82positive regulation of B cell mediated immunity (GO:0002714)3.66345468
83regulation of immunoglobulin mediated immune response (GO:0002889)3.66313493
84response to type I interferon (GO:0034340)3.62825941
85T cell differentiation (GO:0030217)3.62061129
86eosinophil migration (GO:0072677)3.59608046
87immune response-activating cell surface receptor signaling pathway (GO:0002429)3.59465456
88cellular response to type I interferon (GO:0071357)3.57805047
89type I interferon signaling pathway (GO:0060337)3.57805047
90negative regulation of B cell proliferation (GO:0030889)3.57728336
91positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.57634077
92actin nucleation (GO:0045010)3.57077043
93regulation of leukocyte mediated cytotoxicity (GO:0001910)3.56579416
94regulation of B cell mediated immunity (GO:0002712)3.56560259
95macrophage chemotaxis (GO:0048246)3.55023163
96dendritic cell chemotaxis (GO:0002407)3.54574505
97negative regulation of T cell mediated immunity (GO:0002710)3.49459789
98leukocyte cell-cell adhesion (GO:0007159)3.49426419
99positive regulation of immunoglobulin production (GO:0002639)3.48371777
100positive regulation of DNA recombination (GO:0045911)3.47681394
101negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.46874155
102regulation of immunoglobulin production (GO:0002637)3.45598427
103cellular defense response (GO:0006968)3.43872251
104negative regulation of T cell receptor signaling pathway (GO:0050860)3.43776412
105regulation of B cell differentiation (GO:0045577)3.37812954
106* T cell activation (GO:0042110)3.36417283
107regulation of interleukin-4 production (GO:0032673)3.33890102
108regulation of cell killing (GO:0031341)3.32437108
109positive regulation of cell killing (GO:0031343)3.31740495
110positive regulation of interleukin-4 production (GO:0032753)3.31157192
111positive regulation of T cell activation (GO:0050870)3.27173243
112negative regulation of lymphocyte mediated immunity (GO:0002707)3.25777947
113positive regulation of lymphocyte mediated immunity (GO:0002708)3.25772435
114T cell homeostasis (GO:0043029)3.22999048
115negative regulation of B cell activation (GO:0050869)3.22925801
116lymphocyte migration (GO:0072676)3.21051330
117lymph node development (GO:0048535)3.20726454
118antigen processing and presentation via MHC class Ib (GO:0002475)3.20522167
119NIK/NF-kappaB signaling (GO:0038061)3.20307006
120alpha-beta T cell activation (GO:0046631)3.19781231
121positive regulation of monocyte chemotaxis (GO:0090026)3.19757357
122positive regulation of lamellipodium assembly (GO:0010592)3.19596374
123positive regulation of macrophage differentiation (GO:0045651)3.19109334
124alpha-beta T cell differentiation (GO:0046632)3.18831927
125interferon-gamma-mediated signaling pathway (GO:0060333)3.18522175
126positive regulation of T cell mediated immunity (GO:0002711)3.17145118
127regulation of lymphocyte migration (GO:2000401)3.16351258
128mast cell degranulation (GO:0043303)3.09924585
129mast cell activation involved in immune response (GO:0002279)3.09924585
130positive regulation of T cell migration (GO:2000406)3.09668797
131regulation of interleukin-2 production (GO:0032663)3.09146486
132negative regulation of leukocyte mediated immunity (GO:0002704)3.07673110
133chemokine-mediated signaling pathway (GO:0070098)3.06757405
134dendritic cell migration (GO:0036336)3.04595923
135granulocyte activation (GO:0036230)3.04481064
136Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04240752
137regulation of T cell apoptotic process (GO:0070232)3.04134859
138endothelial tube morphogenesis (GO:0061154)2.98616890
139morphogenesis of an endothelium (GO:0003159)2.98616890
140regulation of lymphocyte mediated immunity (GO:0002706)2.97540820
141JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96751950
142T cell proliferation (GO:0042098)2.93203211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.20753213
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.07219666
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.06018094
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.39931045
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.75329562
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.73665487
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.69985278
8* RUNX_20019798_ChIP-Seq_JUKART_Human3.61161471
9* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.53723465
10MYC_22102868_ChIP-Seq_BL_Human3.51953884
11* MYB_26560356_Chip-Seq_TH2_Human3.28020126
12E2F7_22180533_ChIP-Seq_HELA_Human3.21439387
13* MAF_26560356_Chip-Seq_TH1_Human3.12437453
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04959653
15IRF8_21731497_ChIP-ChIP_J774_Mouse3.00168058
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.98562552
17UTX_26944678_Chip-Seq_JUKART_Human2.91077004
18MYB_26560356_Chip-Seq_TH1_Human2.81734844
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35003446
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24294726
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22128341
22* MAF_26560356_Chip-Seq_TH2_Human2.19949540
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.18810631
24VDR_21846776_ChIP-Seq_THP-1_Human2.18622469
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.12857911
26* GATA3_27048872_Chip-Seq_THYMUS_Human2.05709255
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94430358
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92253131
29* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87464782
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87148620
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86718148
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.86028297
33SPI1_23547873_ChIP-Seq_NB4_Human1.85699057
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82213027
35* IRF8_27001747_Chip-Seq_BMDM_Mouse1.80246528
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.79217476
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72186436
38TCF7_22412390_ChIP-Seq_EML_Mouse1.68447375
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63383152
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60512093
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57668529
42VDR_24763502_ChIP-Seq_THP-1_Human1.53450170
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48711366
44KDM2B_26808549_Chip-Seq_DND41_Human1.46029154
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44772545
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44528833
47SCL_19346495_ChIP-Seq_HPC-7_Human1.43554691
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41395766
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40454466
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40434165
51CIITA_25753668_ChIP-Seq_RAJI_Human1.38315175
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36971328
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35246433
54* SPI1_23127762_ChIP-Seq_K562_Human1.32301116
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30488050
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.27064826
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27039006
58VDR_23849224_ChIP-Seq_CD4+_Human1.23859042
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22933905
60GATA3_26560356_Chip-Seq_TH2_Human1.22789088
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20812837
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19341539
63PU_27001747_Chip-Seq_BMDM_Mouse1.17444299
64FOXP3_21729870_ChIP-Seq_TREG_Human1.12828390
65BCL6_27268052_Chip-Seq_Bcells_Human1.12725163
66* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11309895
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10217301
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09169157
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08973588
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.07741452
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06274212
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05194779
73GATA3_26560356_Chip-Seq_TH1_Human1.04804062
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04030116
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.02767437
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01547494
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.01041379
78GATA1_22025678_ChIP-Seq_K562_Human0.97586200
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97096660
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96550794
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95889294
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95027212
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94843096
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91147068
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90711548
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90019244
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89271293
88P300_27268052_Chip-Seq_Bcells_Human0.88658642
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87924756
90EST1_17652178_ChIP-ChIP_JURKAT_Human0.86790353
91E2F4_17652178_ChIP-ChIP_JURKAT_Human0.86014374
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85860567
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85005078
94FOXM1_23109430_ChIP-Seq_U2OS_Human0.83612582
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83182216
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82308175
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82244360
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82214042
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.81633398
100ELK1_19687146_ChIP-ChIP_HELA_Human0.81025391
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79036825
102BCOR_27268052_Chip-Seq_Bcells_Human0.78580940
103PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77476337
104RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77241259
105GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77236765
106SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77143044
107PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76792442
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76354395
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74723094
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74538400
111SMRT_27268052_Chip-Seq_Bcells_Human0.73205251
112GABP_17652178_ChIP-ChIP_JURKAT_Human0.71535072
113CTCF_20526341_ChIP-Seq_ESCs_Human0.71141125
114JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.70778367
115* NANOG_20526341_ChIP-Seq_ESCs_Human0.70527304
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.70350079
117TAF2_19829295_ChIP-Seq_ESCs_Human0.70099315
118* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.68181607
119STAT1_20625510_ChIP-Seq_HELA_Human0.67928876
120* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.67220394
121VDR_24787735_ChIP-Seq_THP-1_Human0.66892945
122* SA1_27219007_Chip-Seq_Bcells_Human0.66521689
123* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.66290835
124YY1_22570637_ChIP-Seq_MALME-3M_Human0.66248046
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66101560
126LXR_22292898_ChIP-Seq_THP-1_Human0.66058081
127CTCF_26484167_Chip-Seq_Bcells_Mouse0.65898615
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.65429366
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.65072693
130CTCF_27219007_Chip-Seq_ERYTHROID_Human0.65013413
131XRN2_22483619_ChIP-Seq_HELA_Human0.64983953
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.63859140
133NFE2_27457419_Chip-Seq_LIVER_Mouse0.63561140
134SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.63456045
135SPI1_20517297_ChIP-Seq_HL60_Human0.62305522
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62166825
137GATA1_19941826_ChIP-Seq_K562_Human0.60745448
138NCOR1_26117541_ChIP-Seq_K562_Human0.60096269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.01918469
2MP0005671_abnormal_response_to5.19831734
3MP0001835_abnormal_antigen_presentation3.93873884
4MP0000685_abnormal_immune_system3.65563207
5MP0002166_altered_tumor_susceptibility3.60675660
6MP0001800_abnormal_humoral_immune3.46697036
7MP0005387_immune_system_phenotype3.30170824
8MP0001790_abnormal_immune_system3.30170824
9MP0005000_abnormal_immune_tolerance3.10464860
10MP0002420_abnormal_adaptive_immunity3.04342937
11MP0001819_abnormal_immune_cell2.99760505
12MP0002723_abnormal_immune_serum2.97616711
13MP0002006_tumorigenesis2.96653915
14MP0002398_abnormal_bone_marrow2.95345346
15MP0009333_abnormal_splenocyte_physiolog2.93146268
16MP0009785_altered_susceptibility_to2.88953477
17MP0002452_abnormal_antigen_presenting2.76964606
18MP0001873_stomach_inflammation2.67442150
19MP0000703_abnormal_thymus_morphology2.66606013
20MP0006082_CNS_inflammation2.66469180
21MP0000716_abnormal_immune_system2.61097365
22MP0005025_abnormal_response_to2.58401554
23MP0002405_respiratory_system_inflammati2.51526837
24MP0002722_abnormal_immune_system2.43182519
25MP0000689_abnormal_spleen_morphology2.32983309
26MP0010155_abnormal_intestine_physiology2.21285616
27MP0003436_decreased_susceptibility_to2.15963493
28MP0003866_abnormal_defecation2.13174983
29MP0002429_abnormal_blood_cell2.10321904
30MP0004947_skin_inflammation2.08756512
31MP0003724_increased_susceptibility_to2.07960170
32MP0002933_joint_inflammation2.05281064
33MP0003300_gastrointestinal_ulcer2.01509738
34MP0002148_abnormal_hypersensitivity_rea1.86021041
35MP0002419_abnormal_innate_immunity1.83786575
36MP0004510_myositis1.82202681
37MP0002396_abnormal_hematopoietic_system1.79998010
38MP0001845_abnormal_inflammatory_respons1.71788569
39MP0002009_preneoplasia1.69125172
40MP0004381_abnormal_hair_follicle1.59084061
41MP0005310_abnormal_salivary_gland1.58345249
42MP0003303_peritoneal_inflammation1.53136906
43MP0005464_abnormal_platelet_physiology1.53015178
44MP0002277_abnormal_respiratory_mucosa1.35704524
45MP0001853_heart_inflammation1.32284961
46MP0000858_altered_metastatic_potential1.29372381
47MP0003448_altered_tumor_morphology1.23466086
48MP0004808_abnormal_hematopoietic_stem1.22563265
49MP0008469_abnormal_protein_level1.19935875
50MP0000465_gastrointestinal_hemorrhage1.18372974
51MP0003786_premature_aging1.13032555
52MP0002019_abnormal_tumor_incidence1.07328803
53MP0003878_abnormal_ear_physiology1.02222363
54MP0005377_hearing/vestibular/ear_phenot1.02222363
55MP0002132_abnormal_respiratory_system1.01076578
56MP0005075_abnormal_melanosome_morpholog1.00751077
57MP0001919_abnormal_reproductive_system1.00581229
58MP0001851_eye_inflammation0.99853510
59MP0000490_abnormal_crypts_of0.99656115
60MP0002138_abnormal_hepatobiliary_system0.96466094
61MP0001533_abnormal_skeleton_physiology0.94822554
62MP0003045_fibrosis0.94590480
63MP0010352_gastrointestinal_tract_polyps0.92715065
64MP0008961_abnormal_basal_metabolism0.91151427
65MP0001501_abnormal_sleep_pattern0.83962616
66MP0002822_catalepsy0.82017571
67MP0002998_abnormal_bone_remodeling0.81922514
68MP0002876_abnormal_thyroid_physiology0.80536204
69MP0002877_abnormal_melanocyte_morpholog0.74861092
70MP0001348_abnormal_lacrimal_gland0.72533951
71MP0005023_abnormal_wound_healing0.68127288
72MP0000569_abnormal_digit_pigmentation0.67624138
73MP0009763_increased_sensitivity_to0.67384469
74MP0001765_abnormal_ion_homeostasis0.66701238
75MP0004145_abnormal_muscle_electrophysio0.65983808
76MP0008057_abnormal_DNA_replication0.65496886
77MP0003075_altered_response_to0.65021262
78MP0003077_abnormal_cell_cycle0.60737905
79MP0002163_abnormal_gland_morphology0.60468701
80MP0000604_amyloidosis0.59846603
81MP0002095_abnormal_skin_pigmentation0.59100364
82MP0000920_abnormal_myelination0.56341826
83MP0002136_abnormal_kidney_physiology0.56030832
84MP0009765_abnormal_xenobiotic_induced0.55651485
85MP0000609_abnormal_liver_physiology0.53233691
86MP0009764_decreased_sensitivity_to0.53129568
87MP0005397_hematopoietic_system_phenotyp0.52812167
88MP0001545_abnormal_hematopoietic_system0.52812167
89MP0001243_abnormal_dermal_layer0.52736285
90MP0000477_abnormal_intestine_morphology0.52158121
91MP0001663_abnormal_digestive_system0.50732339
92MP0008872_abnormal_physiological_respon0.50018980
93MP0003795_abnormal_bone_structure0.49885331
94MP0010307_abnormal_tumor_latency0.49006193
95MP0003183_abnormal_peptide_metabolism0.48952671
96MP0010234_abnormal_vibrissa_follicle0.48891392
97MP0005379_endocrine/exocrine_gland_phen0.48538728
98MP0003787_abnormal_imprinting0.46583583
99MP0001191_abnormal_skin_condition0.45364930
100MP0003011_delayed_dark_adaptation0.45320773
101MP0005389_reproductive_system_phenotype0.44656796
102MP0002693_abnormal_pancreas_physiology0.43759926
103MP0003195_calcinosis0.42526195
104MP0008873_increased_physiological_sensi0.42428696
105MP0003453_abnormal_keratinocyte_physiol0.42087897
106MP0000372_irregular_coat_pigmentation0.41734713
107MP0002168_other_aberrant_phenotype0.41467405
108MP0010094_abnormal_chromosome_stability0.41410071
109MP0005584_abnormal_enzyme/coenzyme_acti0.41359874
110MP0009643_abnormal_urine_homeostasis0.41169088
111MP0005076_abnormal_cell_differentiation0.40955143
112MP0004957_abnormal_blastocyst_morpholog0.40663024
113MP0000015_abnormal_ear_pigmentation0.40528719
114MP0003252_abnormal_bile_duct0.39503092
115MP0000313_abnormal_cell_death0.39191450
116MP0001188_hyperpigmentation0.39184140
117MP0001986_abnormal_taste_sensitivity0.38961082
118MP0002083_premature_death0.38540103
119MP0003646_muscle_fatigue0.37602179
120MP0005319_abnormal_enzyme/_coenzyme0.37096451
121MP0003091_abnormal_cell_migration0.36528600
122MP0005174_abnormal_tail_pigmentation0.36288377
123MP0001216_abnormal_epidermal_layer0.33313243
124MP0005166_decreased_susceptibility_to0.33095904
125MP0008569_lethality_at_weaning0.32831950
126MP0000249_abnormal_blood_vessel0.30911275
127MP0000367_abnormal_coat/_hair0.30681459
128MP0000598_abnormal_liver_morphology0.30494505
129MP0005390_skeleton_phenotype0.30049362
130MP0003693_abnormal_embryo_hatching0.29085149
131MP0008877_abnormal_DNA_methylation0.26181934
132MP0001661_extended_life_span0.25880543

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.20302863
2Abnormality of T cell number (HP:0011839)7.95936168
3Recurrent bronchitis (HP:0002837)5.97680097
4Elevated erythrocyte sedimentation rate (HP:0003565)5.87523117
5Abnormality of T cells (HP:0002843)5.68394119
6Severe combined immunodeficiency (HP:0004430)5.60210085
7Combined immunodeficiency (HP:0005387)5.44488701
8Increased IgM level (HP:0003496)5.07223594
9IgM deficiency (HP:0002850)4.93607870
10IgG deficiency (HP:0004315)4.92276154
11Stomatitis (HP:0010280)4.85404781
12Autoimmune hemolytic anemia (HP:0001890)4.74950728
13Chronic mucocutaneous candidiasis (HP:0002728)4.73564475
14Recurrent cutaneous fungal infections (HP:0011370)4.73564475
15Lymphopenia (HP:0001888)4.61049100
16Recurrent fungal infections (HP:0002841)4.55368984
17Aplastic anemia (HP:0001915)4.50646812
18Abnormality of cells of the lymphoid lineage (HP:0012140)4.45421196
19Recurrent viral infections (HP:0004429)4.41657248
20Chronic otitis media (HP:0000389)4.14020167
21Nasal polyposis (HP:0100582)4.08674119
22Abnormality of eosinophils (HP:0001879)4.02552957
23Panhypogammaglobulinemia (HP:0003139)4.00323108
24Chronic diarrhea (HP:0002028)3.96863729
25Agammaglobulinemia (HP:0004432)3.87874044
26Thyroiditis (HP:0100646)3.82833627
27Hypoproteinemia (HP:0003075)3.82822226
28Eczematoid dermatitis (HP:0000976)3.74484906
29Myositis (HP:0100614)3.69414773
30Recurrent sinusitis (HP:0011108)3.67249706
31Abnormality of the nasal mucosa (HP:0000433)3.62572605
32Eosinophilia (HP:0001880)3.61812840
33B lymphocytopenia (HP:0010976)3.57427452
34Abnormality of B cell number (HP:0010975)3.57427452
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.54393694
36Joint swelling (HP:0001386)3.53510370
37Abnormality of macrophages (HP:0004311)3.50722955
38Leukocytosis (HP:0001974)3.50155004
39Bronchitis (HP:0012387)3.39372700
40Abnormality of T cell physiology (HP:0011840)3.38165649
41Vasculitis (HP:0002633)3.31940162
42Meningitis (HP:0001287)3.28933903
43Hypoplasia of the thymus (HP:0000778)3.27357747
44Gangrene (HP:0100758)3.27002750
45Abnormality of the fingertips (HP:0001211)3.26065155
46Pustule (HP:0200039)3.24469533
47Granulocytopenia (HP:0001913)3.14451118
48Hypergammaglobulinemia (HP:0010702)3.13758445
49Recurrent otitis media (HP:0000403)3.12646316
50Lymphoma (HP:0002665)2.97868455
51Pulmonary infiltrates (HP:0002113)2.97316332
52IgA deficiency (HP:0002720)2.95055575
53Inflammation of the large intestine (HP:0002037)2.89527758
54Autoimmune thrombocytopenia (HP:0001973)2.83700124
55Gastrointestinal inflammation (HP:0004386)2.83360608
56Spontaneous hematomas (HP:0007420)2.83099818
57Recurrent abscess formation (HP:0002722)2.81074295
58Hemoptysis (HP:0002105)2.80515183
59Mediastinal lymphadenopathy (HP:0100721)2.80441230
60Ureteral obstruction (HP:0006000)2.72275454
61Optic neuritis (HP:0100653)2.70417284
62Retrobulbar optic neuritis (HP:0100654)2.70417284
63Recurrent skin infections (HP:0001581)2.69742915
64Encephalitis (HP:0002383)2.69561911
65Papilloma (HP:0012740)2.68071952
66Verrucae (HP:0200043)2.68071952
67Pulmonary fibrosis (HP:0002206)2.67490722
68Chronic sinusitis (HP:0011109)2.64991274
69Obstructive lung disease (HP:0006536)2.62461969
70Chronic obstructive pulmonary disease (HP:0006510)2.62461969
71Hemiplegia (HP:0002301)2.61950940
72Orchitis (HP:0100796)2.56516164
73Gastrointestinal stroma tumor (HP:0100723)2.51176337
74Gastrointestinal infarctions (HP:0005244)2.41138865
75Basal cell carcinoma (HP:0002671)2.40277124
763-Methylglutaconic aciduria (HP:0003535)2.34707980
77Glomerulopathy (HP:0100820)2.25614415
78Cheilitis (HP:0100825)2.23432975
79Increased IgE level (HP:0003212)2.20749497
80Renal cortical cysts (HP:0000803)2.19137994
81Abnormality of the pericardium (HP:0001697)2.16587168
82Emphysema (HP:0002097)2.15741608
83Abnormality of the prostate (HP:0008775)2.14503494
84Hypoalbuminemia (HP:0003073)2.13904769
85Abnormal albumin level (HP:0012116)2.13904769
86Gingival bleeding (HP:0000225)2.13551144
87Abnormality of male internal genitalia (HP:0000022)2.11111834
88Epistaxis (HP:0000421)2.10271744
89Abnormality of binocular vision (HP:0011514)2.09989910
90Diplopia (HP:0000651)2.09989910
91Poikiloderma (HP:0001029)2.09729624
92Reduced subcutaneous adipose tissue (HP:0003758)2.08868152
93Colitis (HP:0002583)2.08374055
94Entropion (HP:0000621)2.07671548
95Premature loss of primary teeth (HP:0006323)2.07346041
96Pulmonary embolism (HP:0002204)2.06044181
97Arterial thrombosis (HP:0004420)2.04424445
98Keratoconjunctivitis sicca (HP:0001097)2.02372580
99Thrombocytosis (HP:0001894)2.01373524
100Chest pain (HP:0100749)1.97693668
101Microcytic anemia (HP:0001935)1.96094530
102Bronchiectasis (HP:0002110)1.96051707
103Petechiae (HP:0000967)1.95052284
104Aplasia/Hypoplasia of the thymus (HP:0010515)1.95034944
105Anorexia (HP:0002039)1.94815047
106Hypochromic anemia (HP:0001931)1.92207449
107Amaurosis fugax (HP:0100576)1.91185058
108Skin rash (HP:0000988)1.91037412
109Pancytopenia (HP:0001876)1.90968229
110Skin ulcer (HP:0200042)1.89824978
111Acute hepatic failure (HP:0006554)1.88537603
112Thrombophlebitis (HP:0004418)1.86637172
113Keratoconjunctivitis (HP:0001096)1.86279950
114Pancreatitis (HP:0001733)1.84404913
115Congenital stationary night blindness (HP:0007642)1.83768735
116Arthralgia (HP:0002829)1.83659021
117Ureteral stenosis (HP:0000071)1.81422022
118Polyneuropathy (HP:0001271)1.80949638
119Cellulitis (HP:0100658)1.80048304
120Restrictive lung disease (HP:0002091)1.79959450
121Stomach cancer (HP:0012126)1.78263659
122Recurrent bacterial skin infections (HP:0005406)1.77910125
123Oral leukoplakia (HP:0002745)1.77471028
124Gingivitis (HP:0000230)1.74200158
125Abnormality of the pleura (HP:0002103)1.73987167
126Keratitis (HP:0000491)1.71344646
127Hepatitis (HP:0012115)1.71020521
128Alveolar cell carcinoma (HP:0006519)1.64465492
129Abnormality of the alveolar ridges (HP:0006477)1.64285335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.06736851
2TXK5.95262709
3ZAP703.33881862
4ITK3.32373234
5FGFR43.14728696
6IKBKE3.10538409
7JAK33.02929673
8TYK22.82094662
9STK102.69147351
10GRK62.47768432
11NLK2.35082884
12TESK22.28619743
13TAOK32.25812142
14LCK2.15776970
15KDR2.13488587
16JAK12.09380435
17FGFR31.97121722
18TBK11.95924397
19MAP3K141.92046924
20CSK1.88571645
21RIPK41.78473690
22SYK1.74874078
23MST41.73063527
24BTK1.61733917
25BCKDK1.61665002
26TEC1.56757033
27HCK1.46374507
28MUSK1.37957745
29BLK1.37585301
30TNK21.31593550
31PRKCQ1.27971548
32PRKCH1.27162492
33NME21.26559561
34GRK71.24639793
35MAP3K101.24174719
36KIT1.22437888
37ADRBK21.15019916
38IRAK41.12459515
39LRRK21.12245741
40MAP3K131.10301739
41PIK3CA1.04272176
42IKBKB1.03980794
43MARK30.99865538
44CAMKK20.96458143
45LYN0.94326553
46CLK10.91609051
47NUAK10.91429991
48ZAK0.89958158
49EEF2K0.86451227
50BUB10.84343789
51MAP4K20.80485282
52MAPKAPK30.80048471
53PIM10.77832764
54JAK20.75904536
55TGFBR20.75772948
56ERN10.75603653
57SIK20.75438832
58CSF1R0.74025494
59PIK3CG0.74014000
60FES0.72268572
61TESK10.70288819
62TLK10.70143746
63SIK30.69338044
64CHUK0.69288883
65INSR0.68112753
66FYN0.64651633
67CDK120.62764801
68MAP3K120.62730261
69BMPR20.60860147
70TRIB30.60299336
71CAMKK10.58486604
72GRK10.57683468
73PKN20.57445896
74PDGFRB0.57199468
75STK40.54535272
76MAP3K70.53584632
77LIMK10.50504299
78TAOK10.50004175
79PRKD20.48366340
80RPS6KA40.48096620
81CDK40.47347932
82MAPK110.44697144
83STK240.44432400
84IGF1R0.44279260
85PDK10.41710436
86FGFR10.40359992
87ALK0.39897183
88WNK40.39160615
89CDK90.37589646
90TYRO30.36556901
91MAP2K20.36113628
92TTN0.34884539
93MATK0.34852516
94NME10.34007410
95HIPK20.33580835
96MARK20.33234076
97EPHA30.32077517
98DAPK10.31285619
99IRAK10.30452257
100EPHB10.29170636
101MAPK70.28893379
102BRD40.28459077
103MAPK30.28355247
104MELK0.26482749
105PASK0.26239872
106MYLK0.25033206
107MAPK120.24690491
108VRK20.23574527
109FGFR20.23136629
110MAP3K110.22031812
111SRC0.21716120
112PRKCD0.21491360
113EGFR0.21065547
114VRK10.20843709
115PRKCA0.20168422
116NEK60.19306005
117FGR0.17993128
118RPS6KA50.17795090
119EIF2AK30.17759283
120IRAK20.17309695
121MAPKAPK20.16154294
122ABL10.15324960
123MAP2K30.15052727
124MAPK40.14758021
125GRK50.14467590
126SIK10.14338682
127MAP3K80.13832050
128NEK90.13549689
129PRKCB0.13409981
130EIF2AK20.12968013
131MAP2K60.12535566
132PRKD10.10887053

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.71119282
2T cell receptor signaling pathway_Homo sapiens_hsa046604.05155298
3Graft-versus-host disease_Homo sapiens_hsa053323.52855041
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.46541250
5Measles_Homo sapiens_hsa051623.08644338
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.00401805
7Antigen processing and presentation_Homo sapiens_hsa046122.82819449
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.77061900
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.74280136
10Allograft rejection_Homo sapiens_hsa053302.57222364
11* Hematopoietic cell lineage_Homo sapiens_hsa046402.27369885
12Viral myocarditis_Homo sapiens_hsa054161.92068490
13B cell receptor signaling pathway_Homo sapiens_hsa046621.90974930
14Leishmaniasis_Homo sapiens_hsa051401.90898147
15Autoimmune thyroid disease_Homo sapiens_hsa053201.89608122
16Osteoclast differentiation_Homo sapiens_hsa043801.79161157
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71295592
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67911472
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.65118614
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60561703
21Herpes simplex infection_Homo sapiens_hsa051681.54854508
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50003596
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.29092487
24Chemokine signaling pathway_Homo sapiens_hsa040621.23557385
25Ribosome_Homo sapiens_hsa030101.22991594
26Type I diabetes mellitus_Homo sapiens_hsa049401.20769083
27Hepatitis B_Homo sapiens_hsa051611.19938690
28Shigellosis_Homo sapiens_hsa051311.19854645
29Toxoplasmosis_Homo sapiens_hsa051451.18471843
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14428480
31* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13508169
32HTLV-I infection_Homo sapiens_hsa051661.13144205
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09256443
34Influenza A_Homo sapiens_hsa051641.07559121
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03880026
36Non-homologous end-joining_Homo sapiens_hsa034500.96507515
37NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95548868
38Malaria_Homo sapiens_hsa051440.95500376
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91628698
40Acute myeloid leukemia_Homo sapiens_hsa052210.91125016
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90977617
42Spliceosome_Homo sapiens_hsa030400.87889692
43Apoptosis_Homo sapiens_hsa042100.87413264
44Epstein-Barr virus infection_Homo sapiens_hsa051690.83103245
45Pancreatic cancer_Homo sapiens_hsa052120.82095640
46Legionellosis_Homo sapiens_hsa051340.79332745
47Asthma_Homo sapiens_hsa053100.79084233
48Salmonella infection_Homo sapiens_hsa051320.77574586
49Tuberculosis_Homo sapiens_hsa051520.76795609
50TNF signaling pathway_Homo sapiens_hsa046680.76583799
51Colorectal cancer_Homo sapiens_hsa052100.74459119
52Viral carcinogenesis_Homo sapiens_hsa052030.74257715
53Proteasome_Homo sapiens_hsa030500.74184522
54Hepatitis C_Homo sapiens_hsa051600.73473004
55RNA polymerase_Homo sapiens_hsa030200.72158809
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70782499
57Oxidative phosphorylation_Homo sapiens_hsa001900.69906013
58Platelet activation_Homo sapiens_hsa046110.69729951
59VEGF signaling pathway_Homo sapiens_hsa043700.69444240
60Staphylococcus aureus infection_Homo sapiens_hsa051500.67139756
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64893742
62Pertussis_Homo sapiens_hsa051330.63016086
63p53 signaling pathway_Homo sapiens_hsa041150.60943881
64Linoleic acid metabolism_Homo sapiens_hsa005910.59560081
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59473637
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57942575
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56319334
68Nucleotide excision repair_Homo sapiens_hsa034200.56035316
69Chronic myeloid leukemia_Homo sapiens_hsa052200.55050612
70Protein export_Homo sapiens_hsa030600.54826784
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53416318
72Prolactin signaling pathway_Homo sapiens_hsa049170.52533770
73African trypanosomiasis_Homo sapiens_hsa051430.51642004
74Parkinsons disease_Homo sapiens_hsa050120.51462647
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51184341
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51047531
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49986783
78DNA replication_Homo sapiens_hsa030300.49978260
79Caffeine metabolism_Homo sapiens_hsa002320.49717245
80Other glycan degradation_Homo sapiens_hsa005110.49710426
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48121770
82Endocytosis_Homo sapiens_hsa041440.47981999
83Mismatch repair_Homo sapiens_hsa034300.47701452
84Phototransduction_Homo sapiens_hsa047440.44551336
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44237808
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43163798
87Nitrogen metabolism_Homo sapiens_hsa009100.42124753
88RNA degradation_Homo sapiens_hsa030180.41535589
89Rheumatoid arthritis_Homo sapiens_hsa053230.41429159
90Base excision repair_Homo sapiens_hsa034100.40010583
91mRNA surveillance pathway_Homo sapiens_hsa030150.38609265
92Notch signaling pathway_Homo sapiens_hsa043300.38133337
93Non-small cell lung cancer_Homo sapiens_hsa052230.34638992
94Adherens junction_Homo sapiens_hsa045200.34186383
95Prion diseases_Homo sapiens_hsa050200.33576772
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32926404
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31921987
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.31427167
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.31110375
100Thyroid cancer_Homo sapiens_hsa052160.30918452
101Small cell lung cancer_Homo sapiens_hsa052220.28909371
102Rap1 signaling pathway_Homo sapiens_hsa040150.28157240
103FoxO signaling pathway_Homo sapiens_hsa040680.26177858
104Alzheimers disease_Homo sapiens_hsa050100.25494956
105MAPK signaling pathway_Homo sapiens_hsa040100.23678079
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23434718
107Regulation of autophagy_Homo sapiens_hsa041400.22186606
108Choline metabolism in cancer_Homo sapiens_hsa052310.20345948
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20195585
110Peroxisome_Homo sapiens_hsa041460.19404483
111RNA transport_Homo sapiens_hsa030130.18387540
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16755801
113Sulfur relay system_Homo sapiens_hsa041220.15888631
114Inositol phosphate metabolism_Homo sapiens_hsa005620.15434485
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15077898
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13865952
117Cell cycle_Homo sapiens_hsa041100.12346767
118Systemic lupus erythematosus_Homo sapiens_hsa053220.12053065
119Endometrial cancer_Homo sapiens_hsa052130.12025154
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.11866889
121mTOR signaling pathway_Homo sapiens_hsa041500.10947610
122Pathways in cancer_Homo sapiens_hsa052000.10793886
123Prostate cancer_Homo sapiens_hsa052150.10351672
124Phagosome_Homo sapiens_hsa041450.09540818
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09365177
126Arachidonic acid metabolism_Homo sapiens_hsa005900.08113496
127Lysosome_Homo sapiens_hsa041420.08001099
128Sulfur metabolism_Homo sapiens_hsa009200.07751705
129Ether lipid metabolism_Homo sapiens_hsa005650.05405148
130ABC transporters_Homo sapiens_hsa020100.04626614
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.04400186
132Ras signaling pathway_Homo sapiens_hsa040140.03541973
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.03455388
134Collecting duct acid secretion_Homo sapiens_hsa049660.01615851
135Pyrimidine metabolism_Homo sapiens_hsa002400.00745793
136Homologous recombination_Homo sapiens_hsa034400.00116635
137Huntingtons disease_Homo sapiens_hsa05016-0.0112437

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