CD1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)7.17652267
2positive regulation of mast cell activation (GO:0033005)5.94927367
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.88914898
4positive regulation of mast cell activation involved in immune response (GO:0033008)5.69172824
5positive regulation of mast cell degranulation (GO:0043306)5.69172824
6B cell mediated immunity (GO:0019724)5.67904483
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.52543857
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.52543857
9modulation by symbiont of host immune response (GO:0052553)5.52543857
10positive regulation by symbiont of host defense response (GO:0052509)5.52543857
11modulation by symbiont of host defense response (GO:0052031)5.52543857
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.52543857
13neutrophil activation involved in immune response (GO:0002283)5.47855081
14regulation of interferon-beta biosynthetic process (GO:0045357)5.44628818
15interferon-gamma-mediated signaling pathway (GO:0060333)5.24253243
16macrophage activation involved in immune response (GO:0002281)5.10740603
17positive regulation of gamma-delta T cell activation (GO:0046645)5.06365837
18cellular extravasation (GO:0045123)5.04479940
19positive thymic T cell selection (GO:0045059)5.02804138
20regulation of hypersensitivity (GO:0002883)4.93632391
21regulation of antigen processing and presentation (GO:0002577)4.82098245
22antigen processing and presentation of endogenous antigen (GO:0019883)4.77145438
23T cell costimulation (GO:0031295)4.66624500
24lymphocyte costimulation (GO:0031294)4.60053432
25regulation of mast cell degranulation (GO:0043304)4.59448739
26detection of bacterium (GO:0016045)4.50664903
27regulation of mast cell activation (GO:0033003)4.48826699
28regulation of B cell receptor signaling pathway (GO:0050855)4.41735612
29detection of other organism (GO:0098543)4.39452726
30positive regulation of antigen processing and presentation (GO:0002579)4.39126839
31negative thymic T cell selection (GO:0045060)4.30665286
32B cell receptor signaling pathway (GO:0050853)4.29891255
33microglial cell activation (GO:0001774)4.27019893
34regulation of mast cell activation involved in immune response (GO:0033006)4.25347582
35regulation of dendritic cell antigen processing and presentation (GO:0002604)4.23031170
36positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.19143052
37cellular response to interferon-gamma (GO:0071346)4.06703227
38myeloid cell activation involved in immune response (GO:0002275)4.06570061
39negative T cell selection (GO:0043383)4.02911307
40positive regulation of leukocyte degranulation (GO:0043302)4.01227401
41positive T cell selection (GO:0043368)3.88446920
42positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.85519901
43positive regulation of type 2 immune response (GO:0002830)3.82909419
44response to peptidoglycan (GO:0032494)3.82770171
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.82553977
46response to host immune response (GO:0052572)3.82553977
47positive regulation of B cell differentiation (GO:0045579)3.77218844
48T-helper 1 type immune response (GO:0042088)3.77063320
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.73093195
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.68613059
51antigen receptor-mediated signaling pathway (GO:0050851)3.60197923
52regulation of leukocyte degranulation (GO:0043300)3.60013546
53respiratory burst (GO:0045730)3.59950581
54T cell selection (GO:0045058)3.59349611
55detection of external biotic stimulus (GO:0098581)3.56418085
56positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.55643459
57response to interferon-gamma (GO:0034341)3.54370981
58positive regulation of macrophage cytokine production (GO:0060907)3.51148317
59regulation of gamma-delta T cell activation (GO:0046643)3.49685640
60chaperone mediated protein folding requiring cofactor (GO:0051085)3.49291832
61regulation of germinal center formation (GO:0002634)3.45494188
62regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.45457594
63neutrophil activation (GO:0042119)3.41594231
64regulation of B cell differentiation (GO:0045577)3.41525801
65response to host defenses (GO:0052200)3.40415465
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40415465
67response to host (GO:0075136)3.40415465
68thymic T cell selection (GO:0045061)3.39533119
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.38926683
70positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.37606282
71positive regulation of interferon-alpha production (GO:0032727)3.36785012
72negative regulation of cell killing (GO:0031342)3.32552065
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.32552065
74T cell receptor signaling pathway (GO:0050852)3.31973790
75regulation of T-helper 2 cell differentiation (GO:0045628)3.31290509
76macrophage activation (GO:0042116)3.28163874
77regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.24108756
78regulation of gamma-delta T cell differentiation (GO:0045586)3.21391689
79granulocyte activation (GO:0036230)3.20301711
80activated T cell proliferation (GO:0050798)3.19327095
81production of molecular mediator of immune response (GO:0002440)3.16144731
82regulation of interferon-alpha production (GO:0032647)3.14490288
83detection of biotic stimulus (GO:0009595)3.13617534
84adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.13184552
85positive regulation of B cell proliferation (GO:0030890)3.12650501
86regulation of type 2 immune response (GO:0002828)3.11522341
87mast cell activation (GO:0045576)3.11247936
88positive regulation of interferon-gamma production (GO:0032729)3.10830171
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09597787
90positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.09520867
91lipoxygenase pathway (GO:0019372)3.09254363
92positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.08741221
93positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08737919
94regulation of inflammatory response to antigenic stimulus (GO:0002861)3.06022663
95negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.03551248
96positive regulation of regulated secretory pathway (GO:1903307)3.03010366
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97310555
98regulation of regulated secretory pathway (GO:1903305)2.91210685
99response to protozoan (GO:0001562)2.90712744
100defense response to protozoan (GO:0042832)2.89645594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.58904053
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.20072055
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.14568015
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.95519261
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.66022357
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42134127
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.38181025
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.32597407
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26866976
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.19154600
11SCL_19346495_ChIP-Seq_HPC-7_Human2.93441185
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86916342
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82772442
14SPI1_23547873_ChIP-Seq_NB4_Human2.75611139
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75438364
16RUNX_20019798_ChIP-Seq_JUKART_Human2.56652174
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49962409
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49376205
19SPI1_23127762_ChIP-Seq_K562_Human2.40082340
20MYB_26560356_Chip-Seq_TH2_Human2.29051237
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.17948959
22VDR_24763502_ChIP-Seq_THP-1_Human2.17803138
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17747257
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12566793
25MYC_22102868_ChIP-Seq_BL_Human2.06095198
26CIITA_25753668_ChIP-Seq_RAJI_Human2.03018017
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02270989
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02061775
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99006923
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97720228
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87846678
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87372811
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87363924
34GATA1_22025678_ChIP-Seq_K562_Human1.82054605
35VDR_24787735_ChIP-Seq_THP-1_Human1.81885688
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.81128245
37VDR_21846776_ChIP-Seq_THP-1_Human1.81024667
38* GATA3_27048872_Chip-Seq_THYMUS_Human1.78565958
39MAF_26560356_Chip-Seq_TH1_Human1.77736895
40MYB_26560356_Chip-Seq_TH1_Human1.66731453
41* UTX_26944678_Chip-Seq_JUKART_Human1.58216528
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56179870
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55981155
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.49496611
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48814970
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45572977
47GATA3_26560356_Chip-Seq_TH2_Human1.42840043
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41380797
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41276222
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41253513
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40837601
52PU_27001747_Chip-Seq_BMDM_Mouse1.37353456
53CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29741475
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26844925
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26802220
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25992840
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22810887
58SPI1_20517297_ChIP-Seq_HL60_Human1.20296026
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19468447
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19141697
61MAF_26560356_Chip-Seq_TH2_Human1.18172217
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16420747
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.15340033
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14527094
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14476084
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11259814
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10977376
68TCF7_22412390_ChIP-Seq_EML_Mouse1.07960808
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07051277
70EGR1_19032775_ChIP-ChIP_M12_Human1.06752475
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03482356
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.01345591
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98780092
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98144996
75BCL6_27268052_Chip-Seq_Bcells_Human0.97256936
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97019743
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96992771
78PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96147071
79SMRT_27268052_Chip-Seq_Bcells_Human0.95254331
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92980932
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90552013
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90452221
83GATA1_19941826_ChIP-Seq_K562_Human0.86411332
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85764321
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85725707
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85637404
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83377287
88* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81324123
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78981935
90LXR_22292898_ChIP-Seq_THP-1_Human0.76076649
91KDM2B_26808549_Chip-Seq_DND41_Human0.74020698
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73977890
93GATA3_26560356_Chip-Seq_TH1_Human0.73410378
94GATA2_19941826_ChIP-Seq_K562_Human0.72917254
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72040811
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71958537
97P300_27268052_Chip-Seq_Bcells_Human0.70995134
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70918330
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.69497164
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.69433478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.18466252
2MP0005671_abnormal_response_to4.87965760
3MP0005387_immune_system_phenotype3.48212705
4MP0001790_abnormal_immune_system3.48212705
5MP0001800_abnormal_humoral_immune3.44824296
6MP0002148_abnormal_hypersensitivity_rea3.29911488
7MP0003436_decreased_susceptibility_to3.07374819
8MP0002452_abnormal_antigen_presenting3.06367495
9MP0002419_abnormal_innate_immunity3.05403629
10MP0005000_abnormal_immune_tolerance2.86944927
11MP0005025_abnormal_response_to2.84849208
12MP0003724_increased_susceptibility_to2.81610970
13MP0000685_abnormal_immune_system2.81564653
14MP0002723_abnormal_immune_serum2.78921845
15MP0002420_abnormal_adaptive_immunity2.64884448
16MP0001819_abnormal_immune_cell2.64246874
17MP0009785_altered_susceptibility_to2.49391108
18MP0003172_abnormal_lysosome_physiology2.47847380
19MP0003303_peritoneal_inflammation2.47177373
20MP0005464_abnormal_platelet_physiology2.30689988
21MP0006082_CNS_inflammation2.21725701
22MP0000716_abnormal_immune_system1.98186075
23MP0002398_abnormal_bone_marrow1.97938760
24MP0003300_gastrointestinal_ulcer1.95061564
25MP0002405_respiratory_system_inflammati1.92100799
26MP0005166_decreased_susceptibility_to1.83960493
27MP0003075_altered_response_to1.82946313
28MP0001853_heart_inflammation1.82065700
29MP0010155_abnormal_intestine_physiology1.81694786
30MP0003763_abnormal_thymus_physiology1.78528618
31MP0002166_altered_tumor_susceptibility1.78235739
32MP0001845_abnormal_inflammatory_respons1.78166795
33MP0008004_abnormal_stomach_pH1.77371525
34MP0000689_abnormal_spleen_morphology1.74794556
35MP0005058_abnormal_lysosome_morphology1.71414213
36MP0002396_abnormal_hematopoietic_system1.70672089
37MP0009333_abnormal_splenocyte_physiolog1.69735501
38MP0004947_skin_inflammation1.67426969
39MP0001533_abnormal_skeleton_physiology1.64258464
40MP0001958_emphysema1.55855414
41MP0002138_abnormal_hepatobiliary_system1.55511706
42MP0002429_abnormal_blood_cell1.55013494
43MP0000465_gastrointestinal_hemorrhage1.51688564
44MP0003183_abnormal_peptide_metabolism1.49302714
45MP0009764_decreased_sensitivity_to1.46177341
46MP0002722_abnormal_immune_system1.46019748
47MP0008469_abnormal_protein_level1.44972507
48MP0003828_pulmonary_edema1.44497609
49MP0003866_abnormal_defecation1.41297860
50MP0002998_abnormal_bone_remodeling1.27221945
51MP0000858_altered_metastatic_potential1.27026694
52MP0000343_altered_response_to1.25998646
53MP0003191_abnormal_cellular_cholesterol1.24443007
54MP0000569_abnormal_digit_pigmentation1.18647979
55MP0002006_tumorigenesis1.17766254
56MP0005075_abnormal_melanosome_morpholog1.17077170
57MP0000015_abnormal_ear_pigmentation1.12102922
58MP0001545_abnormal_hematopoietic_system1.10494146
59MP0005397_hematopoietic_system_phenotyp1.10494146
60MP0005647_abnormal_sex_gland1.10373724
61MP0001986_abnormal_taste_sensitivity1.10365435
62MP0005310_abnormal_salivary_gland1.05611589
63MP0005451_abnormal_body_composition1.04420196
64MP0001851_eye_inflammation1.03515338
65MP0005174_abnormal_tail_pigmentation1.01204474
66MP0001873_stomach_inflammation0.99973841
67MP0003279_aneurysm0.97737354
68MP0000703_abnormal_thymus_morphology0.90897363
69MP0003252_abnormal_bile_duct0.90692552
70MP0000249_abnormal_blood_vessel0.87812225
71MP0004084_abnormal_cardiac_muscle0.86646728
72MP0003448_altered_tumor_morphology0.86577062
73MP0004381_abnormal_hair_follicle0.86403018
74MP0002009_preneoplasia0.84621300
75MP0009763_increased_sensitivity_to0.80410679
76MP0005165_increased_susceptibility_to0.73945628
77MP0004883_abnormal_blood_vessel0.73449459
78MP0003045_fibrosis0.71507547
79MP0000920_abnormal_myelination0.67344210
80MP0009115_abnormal_fat_cell0.67099770
81MP0003806_abnormal_nucleotide_metabolis0.63535445
82MP0008875_abnormal_xenobiotic_pharmacok0.62955910
83MP0000490_abnormal_crypts_of0.62792028
84MP0008874_decreased_physiological_sensi0.59437737
85MP0005390_skeleton_phenotype0.58346076
86MP0003690_abnormal_glial_cell0.57723057
87MP0000371_diluted_coat_color0.57020886
88MP0001663_abnormal_digestive_system0.56138400
89MP0005584_abnormal_enzyme/coenzyme_acti0.55437679
90MP0009765_abnormal_xenobiotic_induced0.54232223
91MP0002132_abnormal_respiratory_system0.53231667
92MP0002019_abnormal_tumor_incidence0.52818365
93MP0001542_abnormal_bone_strength0.52709350
94MP0003091_abnormal_cell_migration0.51567682
95MP0005164_abnormal_response_to0.51227885
96MP0003795_abnormal_bone_structure0.50516845
97MP0002133_abnormal_respiratory_system0.50414841
98MP0005388_respiratory_system_phenotype0.50414841
99MP0009278_abnormal_bone_marrow0.49818647
100MP0004036_abnormal_muscle_relaxation0.49813424

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.51065860
2Vacuolated lymphocytes (HP:0001922)5.44238149
3Abnormality of macrophages (HP:0004311)5.41436660
4Recurrent abscess formation (HP:0002722)5.38819562
5Eczematoid dermatitis (HP:0000976)5.19639856
6Agammaglobulinemia (HP:0004432)4.82595737
7Meningitis (HP:0001287)4.82549210
8Obstructive lung disease (HP:0006536)4.65198832
9Chronic obstructive pulmonary disease (HP:0006510)4.65198832
10Mediastinal lymphadenopathy (HP:0100721)4.46715761
11Chronic mucocutaneous candidiasis (HP:0002728)4.45399423
12Recurrent cutaneous fungal infections (HP:0011370)4.45399423
13Recurrent gram-negative bacterial infections (HP:0005420)4.28266107
14Recurrent skin infections (HP:0001581)4.11982998
15Recurrent fungal infections (HP:0002841)4.10058058
16Chest pain (HP:0100749)3.77352696
17Pulmonary infiltrates (HP:0002113)3.66575074
18Systemic lupus erythematosus (HP:0002725)3.66458713
19Spontaneous hematomas (HP:0007420)3.66030792
20Abnormality of the prostate (HP:0008775)3.58861770
21Vasculitis (HP:0002633)3.57414391
22Urticaria (HP:0001025)3.57079009
23Cellulitis (HP:0100658)3.49602472
24Increased cerebral lipofuscin (HP:0011813)3.49209787
25Colitis (HP:0002583)3.37718304
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.36362349
27Inflammation of the large intestine (HP:0002037)3.34248104
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.33245580
29Hemoptysis (HP:0002105)3.32315568
30Gastrointestinal inflammation (HP:0004386)3.12950594
31Panhypogammaglobulinemia (HP:0003139)3.11142286
32Gastrointestinal infarctions (HP:0005244)3.07387212
33Recurrent viral infections (HP:0004429)3.02273660
34Epistaxis (HP:0000421)3.01987136
35Stomatitis (HP:0010280)3.01449186
36Amyloidosis (HP:0011034)2.95487678
37Osteomyelitis (HP:0002754)2.88591950
38Recurrent pneumonia (HP:0006532)2.87827198
39Restrictive lung disease (HP:0002091)2.80931548
40Gastrointestinal stroma tumor (HP:0100723)2.80920615
41Gingival bleeding (HP:0000225)2.79534290
42Pulmonary fibrosis (HP:0002206)2.74330238
43Increased IgE level (HP:0003212)2.73877669
44Recurrent bronchitis (HP:0002837)2.69247063
45Encephalitis (HP:0002383)2.68299710
46Verrucae (HP:0200043)2.66406464
47Papilloma (HP:0012740)2.66406464
48Dysostosis multiplex (HP:0000943)2.65123182
49Abnormality of the pleura (HP:0002103)2.61480735
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.59691239
51Abnormality of glycolipid metabolism (HP:0010969)2.59691239
52Abnormality of liposaccharide metabolism (HP:0010968)2.59691239
53Gingivitis (HP:0000230)2.58062747
54Elevated erythrocyte sedimentation rate (HP:0003565)2.56136744
55Skin rash (HP:0000988)2.55543046
56Abnormality of the peritoneum (HP:0002585)2.54580347
57Recurrent lower respiratory tract infections (HP:0002783)2.51890490
58Ureteral stenosis (HP:0000071)2.50087540
59Myositis (HP:0100614)2.48766258
60Hepatosplenomegaly (HP:0001433)2.47550153
61Pulmonary embolism (HP:0002204)2.47480702
62Ureteral obstruction (HP:0006000)2.45380751
63Xerostomia (HP:0000217)2.45182496
64Polygenic inheritance (HP:0010982)2.45055069
65Petechiae (HP:0000967)2.42705357
66Amaurosis fugax (HP:0100576)2.41230239
67Gangrene (HP:0100758)2.40378526
68Chronic sinusitis (HP:0011109)2.39527660
69Skin ulcer (HP:0200042)2.39009286
70Prolonged bleeding time (HP:0003010)2.38849295
71T lymphocytopenia (HP:0005403)2.30910657
72Esophageal varix (HP:0002040)2.29569486
73Pustule (HP:0200039)2.29465674
74Purpura (HP:0000979)2.24206457
75Recurrent sinusitis (HP:0011108)2.21669249
76Hypertensive crisis (HP:0100735)2.20859952
77Sepsis (HP:0100806)2.19910499
78Retrobulbar optic neuritis (HP:0100654)2.17900827
79Optic neuritis (HP:0100653)2.17900827
80Abnormality of T cell number (HP:0011839)2.17687152
81Orchitis (HP:0100796)2.14134107
82Spondylolisthesis (HP:0003302)2.11485098
83Polyneuropathy (HP:0001271)2.11480779
84Basal ganglia calcification (HP:0002135)2.10063103
85Leukocytosis (HP:0001974)2.09893039
86Arterial thrombosis (HP:0004420)2.09246771
87Lymphopenia (HP:0001888)2.06716157
88Abnormality of male internal genitalia (HP:0000022)2.06626512
89Mucopolysacchariduria (HP:0008155)2.05340399
90Urinary glycosaminoglycan excretion (HP:0003541)2.05340399
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05098446
92Loss of speech (HP:0002371)2.04431021
93Thrombocytosis (HP:0001894)2.03773932
94Abnormality of T cells (HP:0002843)2.01970566
95Abnormality of polysaccharide metabolism (HP:0011012)1.99032158
96Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99032158
97Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99032158
98Cheilitis (HP:0100825)1.97702685
99Thrombophlebitis (HP:0004418)1.94245283
100Mucosal telangiectasiae (HP:0100579)1.92397352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.80939626
2RIPK44.04216605
3BMPR23.50251417
4CSF1R3.20442062
5MAP4K13.11792287
6TYK23.01437257
7SYK2.45950779
8MAP3K142.39934769
9CDK192.34352978
10FES2.34175805
11JAK32.34031502
12MAP3K132.33720574
13KIT2.18901770
14BTK2.14967723
15IRAK42.06318416
16ZAP702.02525804
17CSK1.94657504
18LYN1.88085187
19PIK3CG1.81372633
20TEC1.61898682
21ITK1.60223156
22TXK1.57209110
23GRK61.53135831
24PRPF4B1.49875741
25TNK21.47767078
26HCK1.45527780
27LCK1.35003232
28TAOK31.32058570
29IKBKB1.31330027
30NEK91.28381260
31JAK11.24390868
32MAP2K31.20760130
33IKBKE1.14559746
34JAK21.14289971
35KDR1.11724670
36ERN11.10548684
37CDC42BPA1.00188496
38GRK70.99112798
39MARK30.99054725
40PRKCQ0.97261133
41MAPK120.93445681
42MAP3K120.90248331
43TBK10.89069131
44MAP3K30.88757441
45FGR0.88197741
46SIK30.87204192
47MAP3K10.85784335
48TLK10.84196563
49TRPM70.83338630
50YES10.79668749
51MAPK70.75455370
52MATK0.75359098
53ARAF0.73637648
54FYN0.72818592
55PDK10.71774754
56OXSR10.69120711
57ABL10.62562292
58MAP2K10.61026509
59CDK60.59786636
60CAMKK20.59601389
61MOS0.56004135
62TTN0.55303430
63TGFBR20.53343069
64PDPK10.51282799
65RPS6KC10.51170404
66RPS6KL10.51170404
67MAP3K110.51082134
68MAP2K20.50773075
69DAPK30.48325895
70RPS6KA60.47530562
71MAPKAPK20.46978725
72TESK20.46697955
73KSR20.46315855
74RPS6KA20.45266404
75MST40.44252459
76MAP3K80.43580248
77CAMK1D0.42692768
78EGFR0.41547263
79PIM20.41247714
80RPS6KA40.40428337
81FLT30.40077342
82STK100.39504558
83IGF1R0.38778115
84MAP3K20.38478556
85FGFR30.37197903
86ILK0.36940153
87CAMKK10.36847148
88PKN10.34288782
89TAOK20.33672318
90PIM10.33041389
91SIK20.32536885
92PRKCD0.32387110
93MAP3K50.32114586
94ADRBK20.30982201
95PTK2B0.30667548
96PRKD10.30181658
97BRD40.28530987
98STK240.27444611
99RAF10.27296951
100STK110.26873828

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.98468018
2Allograft rejection_Homo sapiens_hsa053304.98053110
3Autoimmune thyroid disease_Homo sapiens_hsa053204.70851425
4Graft-versus-host disease_Homo sapiens_hsa053324.68792190
5Intestinal immune network for IgA production_Homo sapiens_hsa046724.26413161
6Type I diabetes mellitus_Homo sapiens_hsa049404.03441583
7Staphylococcus aureus infection_Homo sapiens_hsa051503.84341347
8Leishmaniasis_Homo sapiens_hsa051403.32909855
9Viral myocarditis_Homo sapiens_hsa054163.24265840
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.94029231
11Antigen processing and presentation_Homo sapiens_hsa046122.81799235
12Rheumatoid arthritis_Homo sapiens_hsa053232.29525350
13* Hematopoietic cell lineage_Homo sapiens_hsa046402.22861505
14Tuberculosis_Homo sapiens_hsa051522.12385788
15Toxoplasmosis_Homo sapiens_hsa051451.85356322
16Phagosome_Homo sapiens_hsa041451.64464588
17Primary immunodeficiency_Homo sapiens_hsa053401.55839151
18B cell receptor signaling pathway_Homo sapiens_hsa046621.54089751
19Influenza A_Homo sapiens_hsa051641.53587025
20Herpes simplex infection_Homo sapiens_hsa051681.33780048
21Osteoclast differentiation_Homo sapiens_hsa043801.32567773
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29666275
23Systemic lupus erythematosus_Homo sapiens_hsa053221.26025837
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09777460
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98602258
26NF-kappa B signaling pathway_Homo sapiens_hsa040640.93451813
27Other glycan degradation_Homo sapiens_hsa005110.85218528
28Lysosome_Homo sapiens_hsa041420.80744161
29Chemokine signaling pathway_Homo sapiens_hsa040620.78600397
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76396761
31Epstein-Barr virus infection_Homo sapiens_hsa051690.75185585
32NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74871803
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72236054
34Legionellosis_Homo sapiens_hsa051340.70130690
35Measles_Homo sapiens_hsa051620.68619880
36Pertussis_Homo sapiens_hsa051330.67318184
37Glycosaminoglycan degradation_Homo sapiens_hsa005310.66190722
38T cell receptor signaling pathway_Homo sapiens_hsa046600.64745231
39Platelet activation_Homo sapiens_hsa046110.59019630
40Malaria_Homo sapiens_hsa051440.55164108
41HTLV-I infection_Homo sapiens_hsa051660.54183735
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.53555408
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.51751525
44Salmonella infection_Homo sapiens_hsa051320.50462454
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50402498
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48706118
47Shigellosis_Homo sapiens_hsa051310.47745483
48Acute myeloid leukemia_Homo sapiens_hsa052210.40721347
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39670980
50TNF signaling pathway_Homo sapiens_hsa046680.36618817
51African trypanosomiasis_Homo sapiens_hsa051430.33600988
52Hepatitis B_Homo sapiens_hsa051610.31267945
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30253566
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30190381
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28776408
56Apoptosis_Homo sapiens_hsa042100.26827513
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.25834063
58Hepatitis C_Homo sapiens_hsa051600.24835205
59Non-small cell lung cancer_Homo sapiens_hsa052230.23317235
60Arachidonic acid metabolism_Homo sapiens_hsa005900.21153253
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20422181
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19586167
63Linoleic acid metabolism_Homo sapiens_hsa005910.17834240
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17365036
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15598262
66Endocytosis_Homo sapiens_hsa041440.14477287
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14396551
68Amoebiasis_Homo sapiens_hsa051460.13664354
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12825087
70Galactose metabolism_Homo sapiens_hsa000520.09389234
71Complement and coagulation cascades_Homo sapiens_hsa046100.08837720
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.08824063
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08812693
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08494319
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07604599
76Pancreatic cancer_Homo sapiens_hsa052120.06899309
77VEGF signaling pathway_Homo sapiens_hsa043700.06812288
78Viral carcinogenesis_Homo sapiens_hsa052030.06607325
79Prolactin signaling pathway_Homo sapiens_hsa049170.06569045
80Renal cell carcinoma_Homo sapiens_hsa052110.06047449
81Collecting duct acid secretion_Homo sapiens_hsa049660.05248435
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.04584672
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.03458907
84Salivary secretion_Homo sapiens_hsa049700.03155117
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.02230793
86Gastric acid secretion_Homo sapiens_hsa04971-0.0499268
87Type II diabetes mellitus_Homo sapiens_hsa04930-0.0499261
88Cholinergic synapse_Homo sapiens_hsa04725-0.0476010
89Choline metabolism in cancer_Homo sapiens_hsa05231-0.0475242
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0330323
91mTOR signaling pathway_Homo sapiens_hsa04150-0.0324185
92Renin secretion_Homo sapiens_hsa04924-0.0323783
93alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0322528
94HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0314295
95MAPK signaling pathway_Homo sapiens_hsa04010-0.0282682
96Oxytocin signaling pathway_Homo sapiens_hsa04921-0.0276127
97GnRH signaling pathway_Homo sapiens_hsa04912-0.0247302
98Renin-angiotensin system_Homo sapiens_hsa04614-0.0185979
99Regulation of autophagy_Homo sapiens_hsa04140-0.0112001
100Rap1 signaling pathway_Homo sapiens_hsa04015-0.0022027

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