CD1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)8.77369593
2virion attachment to host cell (GO:0019062)8.77369593
3cellular extravasation (GO:0045123)7.91788647
4wound healing, spreading of epidermal cells (GO:0035313)7.82218183
5adhesion of symbiont to host (GO:0044406)7.66154407
6negative thymic T cell selection (GO:0045060)6.26024607
7long-chain fatty acid biosynthetic process (GO:0042759)6.05700311
8negative T cell selection (GO:0043383)5.84688099
9wound healing, spreading of cells (GO:0044319)5.59282222
10pinocytosis (GO:0006907)5.37350376
11activated T cell proliferation (GO:0050798)5.29165786
12regulation of apoptotic cell clearance (GO:2000425)5.23680520
13lipoxygenase pathway (GO:0019372)5.21204053
14regulation of hypersensitivity (GO:0002883)5.11358841
15negative regulation of inflammatory response to antigenic stimulus (GO:0002862)5.04720544
16positive regulation of gamma-delta T cell activation (GO:0046645)4.99485943
17positive regulation of mast cell activation (GO:0033005)4.77649280
18regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)4.73520925
19mannose metabolic process (GO:0006013)4.73361462
20immunoglobulin mediated immune response (GO:0016064)4.64287929
21glycosphingolipid catabolic process (GO:0046479)4.53152452
22positive regulation of B cell differentiation (GO:0045579)4.43672785
23response to muramyl dipeptide (GO:0032495)4.36908679
24response to peptidoglycan (GO:0032494)4.32608125
25apoptotic cell clearance (GO:0043277)4.30995226
26positive thymic T cell selection (GO:0045059)4.30127732
27leukocyte migration involved in inflammatory response (GO:0002523)4.29917547
28negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.29842463
29positive regulation of antigen processing and presentation (GO:0002579)4.29036503
30regulation of transforming growth factor beta1 production (GO:0032908)4.17640395
31regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.13979922
32positive regulation of mast cell degranulation (GO:0043306)4.11549378
33positive regulation of mast cell activation involved in immune response (GO:0033008)4.11549378
34glycolipid catabolic process (GO:0019377)4.06606528
35thymic T cell selection (GO:0045061)4.06485669
36homeostasis of number of cells within a tissue (GO:0048873)3.99395520
37negative regulation of adaptive immune response (GO:0002820)3.99335607
38receptor guanylyl cyclase signaling pathway (GO:0007168)3.86917558
39regulation of interleukin-2 biosynthetic process (GO:0045076)3.82109050
40T cell selection (GO:0045058)3.80127042
41positive regulation of cellular amide metabolic process (GO:0034250)3.80057462
42positive regulation of macrophage cytokine production (GO:0060907)3.79289932
43regulation of mast cell activation (GO:0033003)3.74131503
44chaperone mediated protein folding requiring cofactor (GO:0051085)3.67701015
45regulation of gamma-delta T cell differentiation (GO:0045586)3.67028666
46negative regulation of type 2 immune response (GO:0002829)3.64934293
47ceramide catabolic process (GO:0046514)3.63749403
48phosphatidylethanolamine biosynthetic process (GO:0006646)3.57520632
49regulation of T-helper 2 cell differentiation (GO:0045628)3.55297178
50positive regulation of chemokine secretion (GO:0090197)3.52318392
51regulation of type 2 immune response (GO:0002828)3.48178431
52negative regulation of T cell mediated immunity (GO:0002710)3.47400847
53positive regulation of type 2 immune response (GO:0002830)3.45271424
54negative regulation of granulocyte differentiation (GO:0030853)3.45265409
55regulation of mast cell degranulation (GO:0043304)3.45007669
56B cell mediated immunity (GO:0019724)3.42590161
57regulation of gamma-delta T cell activation (GO:0046643)3.41691236
58positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.39543470
59T-helper 1 type immune response (GO:0042088)3.39224300
60regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.37837228
61intracellular pH reduction (GO:0051452)3.36434436
62modulation by virus of host morphology or physiology (GO:0019048)3.36271863
63macrophage differentiation (GO:0030225)3.35939408
64regulation of dendritic cell antigen processing and presentation (GO:0002604)3.35610372
65positive T cell selection (GO:0043368)3.34702131
66detection of bacterium (GO:0016045)3.32409911
67signal peptide processing (GO:0006465)3.31136826
68T cell costimulation (GO:0031295)3.30418597
69phosphatidylethanolamine metabolic process (GO:0046337)3.29569022
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28442531
71membrane lipid catabolic process (GO:0046466)3.27702176
72lymphocyte costimulation (GO:0031294)3.25713663
73sphingolipid catabolic process (GO:0030149)3.23363667
74positive regulation of urine volume (GO:0035810)3.19526848
75regulation of mast cell activation involved in immune response (GO:0033006)3.18704202
76pH reduction (GO:0045851)3.16783587
77neutrophil activation involved in immune response (GO:0002283)3.16332639
78detection of other organism (GO:0098543)3.15524807
79nerve growth factor signaling pathway (GO:0038180)3.12941244
80barbed-end actin filament capping (GO:0051016)3.12522968
81leukocyte cell-cell adhesion (GO:0007159)3.11771968
82positive regulation of leukocyte degranulation (GO:0043302)3.09551687
83Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09313812
84antigen processing and presentation of endogenous antigen (GO:0019883)3.09164335
85myeloid dendritic cell differentiation (GO:0043011)3.06702482
86myeloid dendritic cell activation (GO:0001773)3.04921594
87regulation of antigen processing and presentation (GO:0002577)3.04378325
88regulation of leukocyte degranulation (GO:0043300)3.00489591
89protein localization to endosome (GO:0036010)2.99733138
90regulation of inflammatory response to antigenic stimulus (GO:0002861)2.95930424
91myeloid cell development (GO:0061515)2.95380352
92protein targeting to vacuole (GO:0006623)2.94421219
93protein targeting to lysosome (GO:0006622)2.94421219
94establishment of protein localization to vacuole (GO:0072666)2.94421219
95viral genome replication (GO:0019079)2.92109728
96interferon-gamma-mediated signaling pathway (GO:0060333)2.91310489
97regulation of chemokine secretion (GO:0090196)2.89975489
98regulation of myeloid leukocyte mediated immunity (GO:0002886)2.87317904
99fatty acid derivative biosynthetic process (GO:1901570)2.82549670
100icosanoid biosynthetic process (GO:0046456)2.82549670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.36988149
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.15699110
3IRF8_27001747_Chip-Seq_BMDM_Mouse4.20787973
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.15294816
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.55145428
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.47370840
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35133270
8SCL_19346495_ChIP-Seq_HPC-7_Human3.11457531
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.95314986
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91636904
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87207995
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.60413821
13SPI1_23127762_ChIP-Seq_K562_Human2.56099068
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.49092039
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47980414
16SPI1_23547873_ChIP-Seq_NB4_Human2.40496024
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20737414
18VDR_24763502_ChIP-Seq_THP-1_Human2.10461227
19VDR_24787735_ChIP-Seq_THP-1_Human2.04863785
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01369983
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00810904
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.98223078
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95177048
24VDR_21846776_ChIP-Seq_THP-1_Human1.94795804
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91083521
26* GATA3_27048872_Chip-Seq_THYMUS_Human1.83048134
27* MYB_26560356_Chip-Seq_TH2_Human1.77278862
28* RUNX_20019798_ChIP-Seq_JUKART_Human1.75650890
29GATA1_22025678_ChIP-Seq_K562_Human1.75495451
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.70046508
31EGR1_19032775_ChIP-ChIP_M12_Human1.66465106
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66301322
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.65091861
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65081482
35PU_27001747_Chip-Seq_BMDM_Mouse1.64817529
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63652391
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62285040
38MYC_22102868_ChIP-Seq_BL_Human1.61430606
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.58158198
40CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.56772444
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56081906
42GATA1_19941826_ChIP-Seq_K562_Human1.55691043
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52734769
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50802438
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50341170
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49243728
47PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48753108
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48706467
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44976435
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40847427
51LXR_22292898_ChIP-Seq_THP-1_Human1.38941392
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35188046
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34925134
54MAF_26560356_Chip-Seq_TH2_Human1.34065609
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32027290
56* UTX_26944678_Chip-Seq_JUKART_Human1.31958361
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30278996
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29049094
59MAF_26560356_Chip-Seq_TH1_Human1.28473116
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28014003
61MYB_26560356_Chip-Seq_TH1_Human1.27429304
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27352400
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27122284
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23519971
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21646229
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20239729
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17678242
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.15718844
69KDM2B_26808549_Chip-Seq_DND41_Human1.15494986
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12375488
71TCF7_22412390_ChIP-Seq_EML_Mouse1.11321546
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09768953
73* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04671431
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02877398
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.02529227
76GATA2_19941826_ChIP-Seq_K562_Human1.01146267
77KDM2B_26808549_Chip-Seq_K562_Human1.00356775
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99643442
79GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97790231
80ERG_21242973_ChIP-ChIP_JURKAT_Human0.96819440
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96767597
82TFEB_21752829_ChIP-Seq_HELA_Human0.95770711
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95335085
84SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92755667
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91773697
86AHR_22903824_ChIP-Seq_MCF-7_Human0.91538591
87KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90988783
88SPI1_20517297_ChIP-Seq_HL60_Human0.90128718
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90012488
90CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87829186
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87721817
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85544516
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85508434
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.84929608
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84749971
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83980076
97NCOR1_26117541_ChIP-Seq_K562_Human0.83906071
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81841951
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81691247
100TP63_17297297_ChIP-ChIP_HaCaT_Human0.80126952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.16067048
2MP0003279_aneurysm4.49831419
3MP0000569_abnormal_digit_pigmentation4.47614114
4MP0001958_emphysema3.78796224
5MP0003172_abnormal_lysosome_physiology3.53959434
6MP0008004_abnormal_stomach_pH3.18841329
7MP0002148_abnormal_hypersensitivity_rea2.96647222
8MP0001835_abnormal_antigen_presentation2.75113191
9MP0000015_abnormal_ear_pigmentation2.60676268
10MP0005058_abnormal_lysosome_morphology2.57485834
11MP0005387_immune_system_phenotype2.54573536
12MP0001790_abnormal_immune_system2.54573536
13MP0002419_abnormal_innate_immunity2.54198486
14MP0003705_abnormal_hypodermis_morpholog2.50908587
15MP0004947_skin_inflammation2.50664526
16MP0005647_abnormal_sex_gland2.31539695
17MP0005025_abnormal_response_to2.29552924
18MP0005174_abnormal_tail_pigmentation2.25159410
19MP0005166_decreased_susceptibility_to2.18323076
20MP0001853_heart_inflammation2.16822128
21MP0003300_gastrointestinal_ulcer1.98777842
22MP0004084_abnormal_cardiac_muscle1.95476245
23MP0002452_abnormal_antigen_presenting1.91981348
24MP0000343_altered_response_to1.90426947
25MP0002405_respiratory_system_inflammati1.88462828
26MP0005464_abnormal_platelet_physiology1.88452577
27MP0003075_altered_response_to1.79857998
28MP0006082_CNS_inflammation1.73146660
29MP0003436_decreased_susceptibility_to1.72029718
30MP0001819_abnormal_immune_cell1.66071761
31MP0002971_abnormal_brown_adipose1.64401643
32MP0002420_abnormal_adaptive_immunity1.63882937
33MP0003566_abnormal_cell_adhesion1.63584944
34MP0001849_ear_inflammation1.59735443
35MP0010234_abnormal_vibrissa_follicle1.54734031
36MP0009115_abnormal_fat_cell1.54349125
37MP0000685_abnormal_immune_system1.53883105
38MP0002723_abnormal_immune_serum1.53076344
39MP0001727_abnormal_embryo_implantation1.50692122
40MP0001800_abnormal_humoral_immune1.50461930
41MP0005000_abnormal_immune_tolerance1.50071643
42MP0003303_peritoneal_inflammation1.49701107
43MP0001986_abnormal_taste_sensitivity1.42614109
44MP0005670_abnormal_white_adipose1.42309535
45MP0003828_pulmonary_edema1.41010194
46MP0000371_diluted_coat_color1.40349607
47MP0000920_abnormal_myelination1.35880397
48MP0002998_abnormal_bone_remodeling1.29745921
49MP0005451_abnormal_body_composition1.28835507
50MP0000716_abnormal_immune_system1.24399776
51MP0005397_hematopoietic_system_phenotyp1.22663131
52MP0001545_abnormal_hematopoietic_system1.22663131
53MP0001533_abnormal_skeleton_physiology1.20438601
54MP0002398_abnormal_bone_marrow1.17003172
55MP0001845_abnormal_inflammatory_respons1.09772114
56MP0000604_amyloidosis1.09250519
57MP0002877_abnormal_melanocyte_morpholog1.05417018
58MP0001851_eye_inflammation1.04418088
59MP0002295_abnormal_pulmonary_circulatio1.04033702
60MP0002796_impaired_skin_barrier1.01491877
61MP0008874_decreased_physiological_sensi1.01382562
62MP0004036_abnormal_muscle_relaxation1.00452062
63MP0003448_altered_tumor_morphology0.99018550
64MP0003091_abnormal_cell_migration0.98914689
65MP0006138_congestive_heart_failure0.97379477
66MP0002722_abnormal_immune_system0.97348810
67MP0000689_abnormal_spleen_morphology0.96405506
68MP0002429_abnormal_blood_cell0.96383738
69MP0000858_altered_metastatic_potential0.95862127
70MP0009785_altered_susceptibility_to0.95112701
71MP0004381_abnormal_hair_follicle0.95057846
72MP0004185_abnormal_adipocyte_glucose0.93560314
73MP0008469_abnormal_protein_level0.88071553
74MP0003724_increased_susceptibility_to0.85156791
75MP0005075_abnormal_melanosome_morpholog0.83625643
76MP0002396_abnormal_hematopoietic_system0.83221958
77MP0004264_abnormal_extraembryonic_tissu0.83095854
78MP0003453_abnormal_keratinocyte_physiol0.81786414
79MP0005388_respiratory_system_phenotype0.80805068
80MP0002133_abnormal_respiratory_system0.80805068
81MP0000465_gastrointestinal_hemorrhage0.77423748
82MP0002075_abnormal_coat/hair_pigmentati0.74262438
83MP0005409_darkened_coat_color0.73426222
84MP0010329_abnormal_lipoprotein_level0.73170876
85MP0002166_altered_tumor_susceptibility0.71427216
86MP0000639_abnormal_adrenal_gland0.70632149
87MP0003763_abnormal_thymus_physiology0.70162174
88MP0009333_abnormal_splenocyte_physiolog0.69952026
89MP0008260_abnormal_autophagy0.69605059
90MP0010307_abnormal_tumor_latency0.68062310
91MP0004742_abnormal_vestibular_system0.67705245
92MP0010155_abnormal_intestine_physiology0.67438776
93MP0001542_abnormal_bone_strength0.63348177
94MP0005334_abnormal_fat_pad0.62877494
95MP0003634_abnormal_glial_cell0.61863101
96MP0002138_abnormal_hepatobiliary_system0.61790832
97MP0000249_abnormal_blood_vessel0.61326926
98MP0005310_abnormal_salivary_gland0.61077729
99MP0002970_abnormal_white_adipose0.58926906
100MP0005666_abnormal_adipose_tissue0.58727211

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.29641204
2Abnormality of macrophages (HP:0004311)5.96385246
3Recurrent cutaneous fungal infections (HP:0011370)5.71906654
4Chronic mucocutaneous candidiasis (HP:0002728)5.71906654
5Esophageal varix (HP:0002040)5.67093482
6Protuberant abdomen (HP:0001538)5.15110207
7Increased cerebral lipofuscin (HP:0011813)4.37877394
8Recurrent bacterial skin infections (HP:0005406)4.33441834
9Abnormality of liposaccharide metabolism (HP:0010968)4.26859240
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.26859240
11Abnormality of glycolipid metabolism (HP:0010969)4.26859240
12Recurrent skin infections (HP:0001581)4.21289348
13Steatorrhea (HP:0002570)4.20990293
14Increased neuronal autofluorescent lipopigment (HP:0002074)4.09156884
15Hypercholesterolemia (HP:0003124)3.95582211
16Recurrent abscess formation (HP:0002722)3.87474161
17Upper motor neuron abnormality (HP:0002127)3.73187048
18Hepatosplenomegaly (HP:0001433)3.72617152
19Loss of speech (HP:0002371)3.42318957
20Recurrent fungal infections (HP:0002841)3.41577758
21Axonal loss (HP:0003447)3.39746509
22Polygenic inheritance (HP:0010982)3.38029332
23Spontaneous hematomas (HP:0007420)3.33081665
24Multiple lipomas (HP:0001012)3.27889372
25Cheilitis (HP:0100825)3.22630762
26Dysostosis multiplex (HP:0000943)3.16590958
27Mutism (HP:0002300)3.09432628
28Fat malabsorption (HP:0002630)2.97071705
29Meningitis (HP:0001287)2.92417622
30Disinhibition (HP:0000734)2.90673003
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.86923394
32Segmental peripheral demyelination/remyelination (HP:0003481)2.76656443
33Amyloidosis (HP:0011034)2.76427214
34Thoracic kyphosis (HP:0002942)2.69204493
35Albinism (HP:0001022)2.64105135
36Abdominal distention (HP:0003270)2.63801254
37Agnosia (HP:0010524)2.58445205
38Xerostomia (HP:0000217)2.56900182
39Eczematoid dermatitis (HP:0000976)2.54789352
40Scanning speech (HP:0002168)2.54637381
41Flat cornea (HP:0007720)2.50507304
42Cortical dysplasia (HP:0002539)2.50454370
43Hemoptysis (HP:0002105)2.50308676
44Panhypogammaglobulinemia (HP:0003139)2.47809542
45Colitis (HP:0002583)2.41839125
46Distal lower limb muscle weakness (HP:0009053)2.38797709
47Mediastinal lymphadenopathy (HP:0100721)2.37658258
48Progressive visual loss (HP:0000529)2.35196740
49Thick nail (HP:0001805)2.27274193
50Obstructive lung disease (HP:0006536)2.26734309
51Chronic obstructive pulmonary disease (HP:0006510)2.26734309
52Premature loss of primary teeth (HP:0006323)2.26067403
53Abnormality of the lumbar spine (HP:0100712)2.23669670
54Viral hepatitis (HP:0006562)2.23666511
55Inflammation of the large intestine (HP:0002037)2.23538730
56Spondylolisthesis (HP:0003302)2.22099920
57Pustule (HP:0200039)2.18464781
58Recurrent gram-negative bacterial infections (HP:0005420)2.18362226
59Gastrointestinal inflammation (HP:0004386)2.15220049
60Ventricular fibrillation (HP:0001663)2.14923834
61Mucosal telangiectasiae (HP:0100579)2.13068870
62Adactyly (HP:0009776)2.13041744
63Peripheral hypomyelination (HP:0007182)2.12244765
64Pulmonary hypertension (HP:0002092)2.11539710
65Personality changes (HP:0000751)2.06730103
66Pruritus (HP:0000989)2.06160660
67Osteolytic defects of the hand bones (HP:0009699)2.05324041
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.05324041
69Agammaglobulinemia (HP:0004432)2.03304461
70Supernumerary nipples (HP:0002558)2.02524496
71Vacuolated lymphocytes (HP:0001922)12.8522721
72Abnormality of the peritoneum (HP:0002585)1.99496996
73Hypertensive crisis (HP:0100735)1.99471432
74Basal ganglia calcification (HP:0002135)1.99435049
75Diminished motivation (HP:0000745)1.99045041
76Hematochezia (HP:0002573)1.96921163
77Purpura (HP:0000979)1.96417255
78Apathy (HP:0000741)1.94675834
79Acrocyanosis (HP:0001063)1.94663716
80Increased IgE level (HP:0003212)1.94403366
81Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93204034
82Abnormality of polysaccharide metabolism (HP:0011012)1.93204034
83Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93204034
84Neuronal loss in central nervous system (HP:0002529)1.89736688
85Recurrent viral infections (HP:0004429)1.89469074
86Urinary glycosaminoglycan excretion (HP:0003541)1.88543502
87Mucopolysacchariduria (HP:0008155)1.88543502
88Cardiomegaly (HP:0001640)1.86688725
89Bulbar palsy (HP:0001283)1.85610483
90Abnormality of the thoracic spine (HP:0100711)1.85398100
91Onion bulb formation (HP:0003383)1.85279238
92Amaurosis fugax (HP:0100576)1.83071533
93Glomerulonephritis (HP:0000099)1.83021993
94Absent hand (HP:0004050)1.80455835
95Thin bony cortex (HP:0002753)1.79890176
96Abnormality of the periventricular white matter (HP:0002518)1.77008250
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76029730
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.70912752
99Femoral bowing (HP:0002980)1.70455276
100Global brain atrophy (HP:0002283)1.68944122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.55110479
2MAP3K133.36024886
3MAP3K143.12723348
4TYK23.00206316
5RIPK42.78974699
6NEK92.74478794
7TTN2.69178904
8CSF1R2.65338837
9JAK32.45351769
10FES2.27160951
11PRPF4B2.24756342
12GRK72.24087498
13CSK2.21472088
14ITK2.18562746
15CAMK1D2.10246003
16CDC42BPA2.08012163
17PIK3CG1.91417061
18CAMKK21.88045867
19CAMK1G1.87765347
20CDK61.74010108
21EEF2K1.71724424
22LIMK11.69573360
23CAMKK11.64606567
24BTK1.61995300
25KSR21.58156446
26MOS1.53004217
27RPS6KA21.51105356
28DAPK21.47216974
29SYK1.41435943
30STK241.40799420
31ZAP701.40739768
32TRIB31.37715823
33MAP4K11.37280078
34HCK1.33711889
35TRPM71.28341220
36PRKCQ1.23052833
37ARAF1.21028969
38TEC1.12726717
39JAK21.12719951
40MAPK121.09330619
41ADRBK21.03960812
42PIM21.03958111
43MAP3K61.00487148
44MAP3K20.99340907
45YES10.98561967
46SGK30.98020349
47PDPK10.93817262
48MAPK70.93711721
49SMG10.92491804
50PDK10.91011333
51LCK0.89737000
52JAK10.88223674
53LYN0.83737309
54FGR0.83289927
55RPS6KC10.81697843
56RPS6KL10.81697843
57MAP3K10.81565462
58MAPKAPK30.81406142
59CDK120.80528368
60MAP3K80.80115034
61MAP3K90.78144858
62SGK20.76984070
63RAF10.75447847
64TESK20.73605630
65TGFBR20.70195350
66MAP3K50.67370884
67RPS6KA60.65503180
68RET0.63614052
69PKN20.61198248
70TBK10.60010758
71DAPK30.58751271
72IKBKB0.58632833
73PTK2B0.58165262
74MAPKAPK20.55503122
75MAPKAPK50.55022139
76CAMK40.52940021
77KSR10.52748416
78MAP2K40.51341415
79NME20.49516097
80RPS6KB10.49148132
81ERN10.48482322
82DAPK10.47255063
83GSK3A0.42138904
84ABL10.42071572
85PRKACB0.40801555
86MAP2K10.37468107
87CDK40.35826678
88FYN0.35810339
89RPS6KA10.33966983
90ROCK10.33100864
91PDGFRB0.32997681
92PRKG20.32980868
93IGF1R0.32307778
94TAF10.31044669
95SRC0.30896197
96SGK4940.30305504
97SGK2230.30305504
98STK30.29886185
99MAP3K30.29881961
100PRKACG0.28855658

Predicted pathways (KEGG)

RankGene SetZ-score
1* Hematopoietic cell lineage_Homo sapiens_hsa046404.30005947
2Staphylococcus aureus infection_Homo sapiens_hsa051503.87383852
3Asthma_Homo sapiens_hsa053103.75150843
4Steroid biosynthesis_Homo sapiens_hsa001003.22238797
5Allograft rejection_Homo sapiens_hsa053303.19308918
6Autoimmune thyroid disease_Homo sapiens_hsa053203.01851399
7Leishmaniasis_Homo sapiens_hsa051402.80165088
8Graft-versus-host disease_Homo sapiens_hsa053322.79723069
9Tuberculosis_Homo sapiens_hsa051522.79383685
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.77524686
11Lysosome_Homo sapiens_hsa041422.66943196
12Other glycan degradation_Homo sapiens_hsa005112.41367009
13Type I diabetes mellitus_Homo sapiens_hsa049402.29489283
14Phagosome_Homo sapiens_hsa041452.23441126
15Viral myocarditis_Homo sapiens_hsa054162.17994475
16Antigen processing and presentation_Homo sapiens_hsa046121.94486891
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.88804151
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83007140
19Rheumatoid arthritis_Homo sapiens_hsa053231.77257650
20Osteoclast differentiation_Homo sapiens_hsa043801.72377944
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61140867
22Toxoplasmosis_Homo sapiens_hsa051451.49810685
23Chemokine signaling pathway_Homo sapiens_hsa040621.43791410
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.36340764
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32398178
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31488991
27B cell receptor signaling pathway_Homo sapiens_hsa046621.27247223
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26493045
29Linoleic acid metabolism_Homo sapiens_hsa005911.10643462
30Acute myeloid leukemia_Homo sapiens_hsa052211.10354674
31Influenza A_Homo sapiens_hsa051641.08122877
32Pentose phosphate pathway_Homo sapiens_hsa000301.06057435
33Pertussis_Homo sapiens_hsa051330.99548325
34Primary immunodeficiency_Homo sapiens_hsa053400.96541217
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86303833
36Amoebiasis_Homo sapiens_hsa051460.84536113
37Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82700843
38Leukocyte transendothelial migration_Homo sapiens_hsa046700.82101628
39Shigellosis_Homo sapiens_hsa051310.80985472
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79178264
41Platelet activation_Homo sapiens_hsa046110.78281975
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77980184
43Renin secretion_Homo sapiens_hsa049240.73939959
44Legionellosis_Homo sapiens_hsa051340.73525810
45Galactose metabolism_Homo sapiens_hsa000520.72250743
46Complement and coagulation cascades_Homo sapiens_hsa046100.71058660
47Renal cell carcinoma_Homo sapiens_hsa052110.68473745
48Salmonella infection_Homo sapiens_hsa051320.67046060
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65559574
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.65382479
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64524022
52Epstein-Barr virus infection_Homo sapiens_hsa051690.64433203
53Measles_Homo sapiens_hsa051620.63541567
54T cell receptor signaling pathway_Homo sapiens_hsa046600.62392928
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.60120134
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59952030
57Herpes simplex infection_Homo sapiens_hsa051680.59515481
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56641284
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55510537
60Apoptosis_Homo sapiens_hsa042100.52411930
61Prolactin signaling pathway_Homo sapiens_hsa049170.51548235
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51087068
63Arachidonic acid metabolism_Homo sapiens_hsa005900.49059439
64Vibrio cholerae infection_Homo sapiens_hsa051100.47885318
65HTLV-I infection_Homo sapiens_hsa051660.47568790
66Non-small cell lung cancer_Homo sapiens_hsa052230.46825537
67Endocytosis_Homo sapiens_hsa041440.45860127
68Fatty acid elongation_Homo sapiens_hsa000620.45422754
69Chronic myeloid leukemia_Homo sapiens_hsa052200.43468084
70Malaria_Homo sapiens_hsa051440.41829080
71Rap1 signaling pathway_Homo sapiens_hsa040150.41438048
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.40484121
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40051943
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38711354
75Thyroid cancer_Homo sapiens_hsa052160.38286142
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37879858
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.36000764
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.35929375
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34968104
80Insulin resistance_Homo sapiens_hsa049310.34930252
81GnRH signaling pathway_Homo sapiens_hsa049120.34572132
82Systemic lupus erythematosus_Homo sapiens_hsa053220.34376763
83Oxytocin signaling pathway_Homo sapiens_hsa049210.33022785
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32989837
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.32568836
86Renin-angiotensin system_Homo sapiens_hsa046140.32408369
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32009957
88Collecting duct acid secretion_Homo sapiens_hsa049660.31933741
89Inositol phosphate metabolism_Homo sapiens_hsa005620.31517460
90VEGF signaling pathway_Homo sapiens_hsa043700.31393480
91Hepatitis B_Homo sapiens_hsa051610.31030157
92Gastric acid secretion_Homo sapiens_hsa049710.30670066
93Endometrial cancer_Homo sapiens_hsa052130.30292105
94Pancreatic cancer_Homo sapiens_hsa052120.30227392
95Notch signaling pathway_Homo sapiens_hsa043300.29936981
96Estrogen signaling pathway_Homo sapiens_hsa049150.29694978
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28457022
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27784964
99Type II diabetes mellitus_Homo sapiens_hsa049300.26018698
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.23116644

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