CD164

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.80500580
2Golgi transport vesicle coating (GO:0048200)9.80500580
3definitive hemopoiesis (GO:0060216)6.82413407
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.59888790
5COPII vesicle coating (GO:0048208)6.30942739
6protein retention in ER lumen (GO:0006621)5.76204206
7negative regulation of neurotransmitter secretion (GO:0046929)5.67068824
8positive regulation of vasculogenesis (GO:2001214)5.53790143
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.50719662
10signal peptide processing (GO:0006465)5.21351193
11endocrine pancreas development (GO:0031018)5.17711856
12activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.07904502
13positive regulation of nuclease activity (GO:0032075)4.87099843
14protein maturation by protein folding (GO:0022417)4.78255150
15exocrine pancreas development (GO:0031017)4.61482169
16thrombin receptor signaling pathway (GO:0070493)4.52772593
17peptide hormone processing (GO:0016486)4.50058553
18endoplasmic reticulum unfolded protein response (GO:0030968)4.49997014
19positive regulation of B cell differentiation (GO:0045579)4.45959266
20regulation of nuclease activity (GO:0032069)4.45611111
21cellular response to unfolded protein (GO:0034620)4.39683310
22regulation of T-helper 1 cell differentiation (GO:0045625)4.35910935
23vesicle coating (GO:0006901)4.29318241
24negative regulation of granulocyte differentiation (GO:0030853)4.28758177
25sequestering of metal ion (GO:0051238)4.27188745
26regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.25134522
27positive regulation of granulocyte differentiation (GO:0030854)4.24815388
28ER-nucleus signaling pathway (GO:0006984)4.23664941
29nerve growth factor signaling pathway (GO:0038180)4.22453277
30cellular response to topologically incorrect protein (GO:0035967)4.21643927
31glandular epithelial cell differentiation (GO:0002067)4.15951478
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.09143095
33negative regulation of neurotransmitter transport (GO:0051589)4.07503855
34type B pancreatic cell development (GO:0003323)4.03720014
35regulation of type B pancreatic cell apoptotic process (GO:2000674)3.92002086
36Rap protein signal transduction (GO:0032486)3.88656376
374-hydroxyproline metabolic process (GO:0019471)3.83015086
38negative regulation of T-helper cell differentiation (GO:0045623)3.82446882
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.82446882
40negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.77878229
41glandular epithelial cell development (GO:0002068)3.77811645
42L-phenylalanine catabolic process (GO:0006559)3.71080916
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.71080916
44ER overload response (GO:0006983)3.69272498
45regulation of vasculogenesis (GO:2001212)3.68078031
46response to endoplasmic reticulum stress (GO:0034976)3.61135715
47positive regulation of gamma-delta T cell activation (GO:0046645)3.60948992
48regulation of B cell receptor signaling pathway (GO:0050855)3.55201252
49valine metabolic process (GO:0006573)3.50062826
50negative regulation of erythrocyte differentiation (GO:0045647)3.49331420
51tricarboxylic acid metabolic process (GO:0072350)3.49308163
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.48306117
53L-phenylalanine metabolic process (GO:0006558)3.48306117
54rRNA methylation (GO:0031167)3.47722847
55negative regulation of glycoprotein biosynthetic process (GO:0010561)3.46030381
56megakaryocyte development (GO:0035855)3.41431300
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40199687
58ER to Golgi vesicle-mediated transport (GO:0006888)3.37317370
59positive regulation of T-helper cell differentiation (GO:0045624)3.36899152
60response to unfolded protein (GO:0006986)3.36615067
61regulation of memory T cell differentiation (GO:0043380)3.34820342
62protein N-linked glycosylation via asparagine (GO:0018279)3.33817479
63peptidyl-asparagine modification (GO:0018196)3.33650287
64positive regulation of glycolytic process (GO:0045821)3.30987089
65response to topologically incorrect protein (GO:0035966)3.27628586
66macroautophagy (GO:0016236)3.26868555
67mature B cell differentiation involved in immune response (GO:0002313)3.25670436
68UDP-N-acetylglucosamine metabolic process (GO:0006047)3.25075040
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.24842495
70regulation of B cell differentiation (GO:0045577)3.24704856
71regulation of Golgi to plasma membrane protein transport (GO:0042996)3.21128171
72L-alpha-amino acid transmembrane transport (GO:1902475)3.20520412
73regulation of granulocyte differentiation (GO:0030852)3.19684213
74positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.19584364
75cellular response to vitamin D (GO:0071305)3.18769806
76endothelium development (GO:0003158)3.18375757
77negative regulation of bone resorption (GO:0045779)3.16855620
78mucosal-associated lymphoid tissue development (GO:0048537)3.16099737
79Peyers patch development (GO:0048541)3.16099737
80neutrophil activation involved in immune response (GO:0002283)3.13015801
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11321374
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.11273109
83antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11273109
84poly(A)+ mRNA export from nucleus (GO:0016973)3.09624014
85interkinetic nuclear migration (GO:0022027)3.08421973
86positive regulation of interleukin-17 production (GO:0032740)3.08164493
87columnar/cuboidal epithelial cell development (GO:0002066)3.06975833
88positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.04915699
89regulation of cholesterol homeostasis (GO:2000188)3.04781444
90protein N-linked glycosylation (GO:0006487)3.04121799
91regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.04117741
92regulation of platelet aggregation (GO:0090330)3.03328626
93toxin metabolic process (GO:0009404)3.01805117
94peptide catabolic process (GO:0043171)3.00964121
95establishment of endothelial barrier (GO:0061028)3.00867739
96regulation of female gonad development (GO:2000194)3.00670294
97positive regulation of insulin secretion (GO:0032024)3.00245273
98regulation of RIG-I signaling pathway (GO:0039535)2.96758383
99rRNA modification (GO:0000154)2.95786505
100negative regulation of glycoprotein metabolic process (GO:1903019)2.93025849
101phospholipid scrambling (GO:0017121)2.92058650
102regulation of gamma-delta T cell differentiation (GO:0045586)2.91756021
103positive regulation of alpha-beta T cell proliferation (GO:0046641)2.91366781
104regulation of regulatory T cell differentiation (GO:0045589)2.90658743
105Golgi organization (GO:0007030)2.88633452
106cellular zinc ion homeostasis (GO:0006882)2.88362411
107sulfur amino acid catabolic process (GO:0000098)2.87233437
108drug transmembrane transport (GO:0006855)2.85780934
109formation of translation preinitiation complex (GO:0001731)2.85766547
110regulation of interleukin-17 production (GO:0032660)2.85454669
111positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.81603160
112aggressive behavior (GO:0002118)2.81332532
113mature B cell differentiation (GO:0002335)2.75787795
114aromatic amino acid family catabolic process (GO:0009074)2.75221431
115regulation of T-helper cell differentiation (GO:0045622)2.72640256
116intestinal absorption (GO:0050892)2.72229849
117Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72134796
118B cell receptor signaling pathway (GO:0050853)2.71072929
119regulation of glucokinase activity (GO:0033131)2.69713625
120regulation of hexokinase activity (GO:1903299)2.69713625
121protein carboxylation (GO:0018214)2.69502613
122peptidyl-glutamic acid carboxylation (GO:0017187)2.69502613
123protein autoprocessing (GO:0016540)2.69456810
124positive regulation of Rap GTPase activity (GO:0032854)2.69452454
125intestinal cholesterol absorption (GO:0030299)2.68910711
126positive regulation of T cell cytokine production (GO:0002726)2.68819548
127response to peptidoglycan (GO:0032494)2.68248723
128regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.64749081
129regulation of establishment of cell polarity (GO:2000114)2.64709239
130positive regulation of hormone biosynthetic process (GO:0046886)2.64116409
131regulation of gamma-delta T cell activation (GO:0046643)2.63323840
132intra-Golgi vesicle-mediated transport (GO:0006891)2.63311406
133growth hormone receptor signaling pathway (GO:0060396)2.62536464
134hormone catabolic process (GO:0042447)2.61858930
135regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.61448855
136negative regulation of bone remodeling (GO:0046851)2.58914726
137cellular response to vitamin (GO:0071295)2.57749262
138alpha-linolenic acid metabolic process (GO:0036109)2.57075600
139positive regulation of transforming growth factor beta production (GO:0071636)2.57012225
140antigen processing and presentation of endogenous antigen (GO:0019883)2.56984505
141keratan sulfate catabolic process (GO:0042340)2.55120534
142lysine metabolic process (GO:0006553)2.54089433
143lysine catabolic process (GO:0006554)2.54089433
144regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.53148291
145insulin secretion (GO:0030073)2.52552879
146negative regulation of tissue remodeling (GO:0034104)2.51880742
147positive regulation of histone deacetylation (GO:0031065)2.51664586
148regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.49495889
149negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.48991591
150response to hexose (GO:0009746)2.48705839
151gland morphogenesis (GO:0022612)2.48371088
152regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.48270787
153regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.47723144
154folic acid-containing compound biosynthetic process (GO:0009396)2.47681956
155negative regulation of alpha-beta T cell differentiation (GO:0046639)2.47157858
156regulation of alpha-beta T cell proliferation (GO:0046640)2.46909607
157positive regulation of peptide hormone secretion (GO:0090277)2.46213756
158fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45430213
159regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.44218028
160apoptotic cell clearance (GO:0043277)2.43345179
161cysteine metabolic process (GO:0006534)2.43314478
162epithelial cell fate commitment (GO:0072148)2.42806824
163necroptotic process (GO:0070266)2.42340520
164regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.42172656
165response to monosaccharide (GO:0034284)2.41342967
166response to glucose (GO:0009749)2.41212782
167ribosome assembly (GO:0042255)2.40587423
168misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.39486426
169fatty acid homeostasis (GO:0055089)2.39438356
170negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.39385410
171regulation of T-helper 1 type immune response (GO:0002825)2.39221232
172negative regulation of interleukin-17 production (GO:0032700)2.38737881
173regulation of cholesterol biosynthetic process (GO:0045540)2.38103751
174parental behavior (GO:0060746)2.37920470
175regulation of T-helper 2 cell differentiation (GO:0045628)2.36397649
176positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34013710
177cellular response to thyroid hormone stimulus (GO:0097067)2.33926029
178actin nucleation (GO:0045010)2.31520257
179histamine secretion (GO:0001821)2.31472188
180positive regulation of lymphocyte differentiation (GO:0045621)2.31413401
181positive regulation of T cell differentiation (GO:0045582)2.31199247
182positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.30712116
183immunoglobulin mediated immune response (GO:0016064)2.30617456
184thyroid gland development (GO:0030878)2.30373166
185positive regulation of alpha-beta T cell activation (GO:0046635)2.30117792
186regulation of germinal center formation (GO:0002634)2.29250608
187programmed necrotic cell death (GO:0097300)2.28890420
188epithelial cell differentiation involved in kidney development (GO:0035850)2.28086522
189relaxation of smooth muscle (GO:0044557)2.27971050
190cellular response to nerve growth factor stimulus (GO:1990090)2.27872550
191response to nerve growth factor (GO:1990089)2.27872550
192negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.26415780
193negative regulation of cell killing (GO:0031342)2.26415780
194B cell mediated immunity (GO:0019724)2.26128254
195positive regulation of interleukin-2 production (GO:0032743)2.25352755
196positive regulation of alpha-beta T cell differentiation (GO:0046638)2.23843709
197embryonic process involved in female pregnancy (GO:0060136)2.23110551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.99874109
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.44436174
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.42952422
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.17863198
5SCL_19346495_ChIP-Seq_HPC-7_Human3.89895982
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.81053875
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.54914112
8CLOCK_20551151_ChIP-Seq_293T_Human3.35492198
9GATA1_22025678_ChIP-Seq_K562_Human3.27040475
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.05793304
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.64637066
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.57987702
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53053238
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.51224510
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50832182
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50528035
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.50370823
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.49328323
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.43123846
20RUNX_20019798_ChIP-Seq_JUKART_Human2.37594027
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.26676188
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.25834050
23SOX2_27498859_Chip-Seq_STOMACH_Mouse2.14971233
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.07981860
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.07745282
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05806362
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04388390
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.93054063
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92078152
30SPI1_23547873_ChIP-Seq_NB4_Human1.90451675
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81134544
32* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80765607
33* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75896030
34IGF1R_20145208_ChIP-Seq_DFB_Human1.75650579
35* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75393935
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75064375
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.74118208
38FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.69951114
39* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.61108084
40VDR_24787735_ChIP-Seq_THP-1_Human1.60671768
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57996612
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.54675584
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54415052
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54046416
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53890044
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49652798
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48258064
48GATA4_25053715_ChIP-Seq_YYC3_Human1.47993898
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43291931
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.43057515
51* TFEB_21752829_ChIP-Seq_HELA_Human1.41833005
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40415581
53SOX2_20726797_ChIP-Seq_SW620_Human1.37669795
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37335082
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36907490
56* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36631920
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36405280
58VDR_24763502_ChIP-Seq_THP-1_Human1.35138627
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.34711297
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31861065
61FUS_26573619_Chip-Seq_HEK293_Human1.31772921
62GATA6_25053715_ChIP-Seq_YYC3_Human1.31332481
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30857935
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29261785
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28145841
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27786210
67GATA3_27048872_Chip-Seq_THYMUS_Human1.27279027
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26996704
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.26925118
70* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25596308
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23762232
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23380375
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.22207936
74* GATA3_24758297_ChIP-Seq_MCF-7_Human1.21844062
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21538960
76GATA2_19941826_ChIP-Seq_K562_Human1.20398980
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.19308806
78CDX2_22108803_ChIP-Seq_LS180_Human1.18919443
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.18883509
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18246938
81* RUNX1_22412390_ChIP-Seq_EML_Mouse1.18236956
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17942020
83VDR_22108803_ChIP-Seq_LS180_Human1.17365478
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16803217
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.16746041
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16373058
87CHD1_26751641_Chip-Seq_LNCaP_Human1.15400378
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14727886
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13979649
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13565758
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12608574
92ZNF263_19887448_ChIP-Seq_K562_Human1.11976569
93* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11738399
94* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11738399
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11584687
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10136605
97* MYC_22102868_ChIP-Seq_BL_Human1.10099836
98* MYB_26560356_Chip-Seq_TH2_Human1.08749092
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08005633
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07516855
101FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07365330
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07336151
103SPI1_23127762_ChIP-Seq_K562_Human1.07253935
104ATF3_27146783_Chip-Seq_COLON_Human1.05342983
105* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04499800
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03329959
107ER_23166858_ChIP-Seq_MCF-7_Human1.03185506
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02386990
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01769242
110STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01501135
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01174275
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00843655
113EWS_26573619_Chip-Seq_HEK293_Human1.00284937
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99975797
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99045111
116* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98977626
117FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97936147
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.97936147
119* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97903173
120* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97336373
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.96676368
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.96676368
123GATA1_19941826_ChIP-Seq_K562_Human0.95843233
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95472028
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95236671
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94477103
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94244568
128MYB_26560356_Chip-Seq_TH1_Human0.93203089
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91673288
130MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91501248
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.90641797
132PU_27001747_Chip-Seq_BMDM_Mouse0.90230958
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.90101423
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88698097
135* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88641501
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88489005
137* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88182040
138* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87910694
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86482970
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85386313
141BRD4_25478319_ChIP-Seq_HGPS_Human0.85359140
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.84949089
143* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84596605
144ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84397320
145* IRF8_27001747_Chip-Seq_BMDM_Mouse0.84186215
146* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83843024
147GATA3_26560356_Chip-Seq_TH2_Human0.83636819
148SMRT_27268052_Chip-Seq_Bcells_Human0.82702439
149RUNX1_27514584_Chip-Seq_MCF-7_Human0.82489074
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82294232
151* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82102281
152RACK7_27058665_Chip-Seq_MCF-7_Human0.81320918
153TP63_23658742_ChIP-Seq_EP156T_Human0.81236504
154ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81059928
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80941312
156HNF4A_19822575_ChIP-Seq_HepG2_Human0.80676668
157GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80602478
158* AR_20517297_ChIP-Seq_VCAP_Human0.79478837
159SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.78832451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.04834922
2MP0002877_abnormal_melanocyte_morpholog3.85602595
3MP0003195_calcinosis3.43929829
4MP0002139_abnormal_hepatobiliary_system3.23985367
5MP0005464_abnormal_platelet_physiology3.20387075
6MP0005365_abnormal_bile_salt3.02310857
7MP0003283_abnormal_digestive_organ2.91213640
8MP0001835_abnormal_antigen_presentation2.90712523
9MP0004808_abnormal_hematopoietic_stem2.88443858
10MP0002693_abnormal_pancreas_physiology2.73367826
11MP0001944_abnormal_pancreas_morphology2.64591171
12MP0005220_abnormal_exocrine_pancreas2.61922603
13MP0000013_abnormal_adipose_tissue2.61908662
14MP0003300_gastrointestinal_ulcer2.61612943
15MP0004043_abnormal_pH_regulation2.59284910
16MP0003252_abnormal_bile_duct2.53355278
17MP0009780_abnormal_chondrocyte_physiolo2.43707256
18MP0004264_abnormal_extraembryonic_tissu2.33270152
19MP0003763_abnormal_thymus_physiology2.32726776
20MP0002909_abnormal_adrenal_gland2.24424388
21MP0000465_gastrointestinal_hemorrhage2.23781005
22MP0009697_abnormal_copulation2.19799932
23MP0003183_abnormal_peptide_metabolism2.17950735
24MP0005360_urolithiasis2.17806135
25MP0005085_abnormal_gallbladder_physiolo2.17134593
26MP0006054_spinal_hemorrhage2.04749037
27MP0005397_hematopoietic_system_phenotyp2.03041858
28MP0001545_abnormal_hematopoietic_system2.03041858
29MP0002138_abnormal_hepatobiliary_system1.99710770
30MP0002148_abnormal_hypersensitivity_rea1.97977827
31MP0010155_abnormal_intestine_physiology1.96931509
32MP0005058_abnormal_lysosome_morphology1.88039968
33MP0003656_abnormal_erythrocyte_physiolo1.85849432
34MP0009643_abnormal_urine_homeostasis1.85183666
35MP0000681_abnormal_thyroid_gland1.84359605
36MP0003303_peritoneal_inflammation1.83225115
37MP0000678_abnormal_parathyroid_gland1.77714020
38MP0005379_endocrine/exocrine_gland_phen1.77157014
39MP0009840_abnormal_foam_cell1.73748702
40MP0005000_abnormal_immune_tolerance1.70363297
41MP0002078_abnormal_glucose_homeostasis1.68266914
42MP0002928_abnormal_bile_duct1.65229100
43MP0001664_abnormal_digestion1.61166374
44MP0009785_altered_susceptibility_to1.59677385
45MP0001800_abnormal_humoral_immune1.59538196
46MP0002896_abnormal_bone_mineralization1.58761063
47MP0001666_abnormal_nutrient_absorption1.56507183
48MP0000003_abnormal_adipose_tissue1.55710160
49MP0001790_abnormal_immune_system1.53704074
50MP0005387_immune_system_phenotype1.53704074
51MP0002132_abnormal_respiratory_system1.53393987
52MP0002837_dystrophic_cardiac_calcinosis1.52151714
53MP0003191_abnormal_cellular_cholesterol1.51520584
54MP0008875_abnormal_xenobiotic_pharmacok1.49515963
55MP0002398_abnormal_bone_marrow1.49011207
56MP0002723_abnormal_immune_serum1.47498693
57MP0005084_abnormal_gallbladder_morpholo1.45640786
58MP0006082_CNS_inflammation1.45596652
59MP0000689_abnormal_spleen_morphology1.44059832
60MP0002452_abnormal_antigen_presenting1.43168238
61MP0003436_decreased_susceptibility_to1.41956853
62MP0009333_abnormal_splenocyte_physiolog1.41805179
63MP0002405_respiratory_system_inflammati1.41441274
64MP0010234_abnormal_vibrissa_follicle1.40970928
65MP0003705_abnormal_hypodermis_morpholog1.40741534
66MP0000609_abnormal_liver_physiology1.40702418
67MP0005025_abnormal_response_to1.40617317
68MP0001819_abnormal_immune_cell1.40087507
69MP0002420_abnormal_adaptive_immunity1.39753838
70MP0010386_abnormal_urinary_bladder1.39543223
71MP0002166_altered_tumor_susceptibility1.39315854
72MP0010329_abnormal_lipoprotein_level1.38736088
73MP0002419_abnormal_innate_immunity1.36581964
74MP0003828_pulmonary_edema1.30822752
75MP0001756_abnormal_urination1.29908469
76MP0005670_abnormal_white_adipose1.26837135
77MP0002722_abnormal_immune_system1.25262555
78MP0005075_abnormal_melanosome_morpholog1.21889047
79MP0000716_abnormal_immune_system1.21473268
80MP0005332_abnormal_amino_acid1.20222452
81MP0003806_abnormal_nucleotide_metabolis1.19697368
82MP0008961_abnormal_basal_metabolism1.19045814
83MP0003566_abnormal_cell_adhesion1.17745029
84MP0005165_increased_susceptibility_to1.15705752
85MP0003172_abnormal_lysosome_physiology1.14628066
86MP0001765_abnormal_ion_homeostasis1.14478826
87MP0002006_tumorigenesis1.14118299
88MP0002118_abnormal_lipid_homeostasis1.13596565
89MP0003868_abnormal_feces_composition1.13439564
90MP0005083_abnormal_biliary_tract1.11671149
91MP0009278_abnormal_bone_marrow1.10939439
92MP0000685_abnormal_immune_system1.10650207
93MP0002429_abnormal_blood_cell1.09488777
94MP0005409_darkened_coat_color1.08130127
95MP0005076_abnormal_cell_differentiation1.07854147
96MP0008438_abnormal_cutaneous_collagen1.06439321
97MP0005375_adipose_tissue_phenotype1.05859925
98MP0005636_abnormal_mineral_homeostasis1.05002175
99MP0000613_abnormal_salivary_gland1.02165269
100MP0001191_abnormal_skin_condition1.01789055
101MP0005166_decreased_susceptibility_to1.01438303
102MP0010352_gastrointestinal_tract_polyps1.01054290
103MP0005671_abnormal_response_to0.99334547
104MP0004019_abnormal_vitamin_homeostasis0.98721019
105MP0002254_reproductive_system_inflammat0.98628356
106MP0000703_abnormal_thymus_morphology0.98548004
107MP0001873_stomach_inflammation0.97559286
108MP0003279_aneurysm0.97437561
109MP0003075_altered_response_to0.95938818
110MP0003943_abnormal_hepatobiliary_system0.95403239
111MP0005319_abnormal_enzyme/_coenzyme0.94300769
112MP0004484_altered_response_of0.93742178
113MP0004947_skin_inflammation0.93150549
114MP0003724_increased_susceptibility_to0.91022497
115MP0003953_abnormal_hormone_level0.90994137
116MP0002168_other_aberrant_phenotype0.90377855
117MP0005310_abnormal_salivary_gland0.90105371
118MP0003795_abnormal_bone_structure0.90016861
119MP0001188_hyperpigmentation0.88496586
120MP0004147_increased_porphyrin_level0.87983162
121MP0001851_eye_inflammation0.87086919
122MP0000858_altered_metastatic_potential0.85816660
123MP0000598_abnormal_liver_morphology0.83940157
124MP0004084_abnormal_cardiac_muscle0.83689365
125MP0001661_extended_life_span0.83021721
126MP0003045_fibrosis0.82994645
127MP0000462_abnormal_digestive_system0.82828532
128MP0005666_abnormal_adipose_tissue0.82167426
129MP0009384_cardiac_valve_regurgitation0.81948294
130MP0003959_abnormal_lean_body0.81881300
131MP0005408_hypopigmentation0.79530582
132MP0002060_abnormal_skin_morphology0.78825630
133MP0009672_abnormal_birth_weight0.78036690
134MP0002019_abnormal_tumor_incidence0.77941768
135MP0000249_abnormal_blood_vessel0.77737684
136MP0004185_abnormal_adipocyte_glucose0.77580253
137MP0005334_abnormal_fat_pad0.76821143
138MP0005275_abnormal_skin_tensile0.75848247
139MP0001533_abnormal_skeleton_physiology0.75015698
140MP0002234_abnormal_pharynx_morphology0.74606206
141MP0002876_abnormal_thyroid_physiology0.73669137
142MP0009642_abnormal_blood_homeostasis0.73459426
143MP0002136_abnormal_kidney_physiology0.73132194
144MP0001270_distended_abdomen0.72949930
145MP0000230_abnormal_systemic_arterial0.72307870
146MP0008057_abnormal_DNA_replication0.71018001
147MP0004272_abnormal_basement_membrane0.69674245
148MP0005257_abnormal_intraocular_pressure0.68668755
149MP0001845_abnormal_inflammatory_respons0.66471898
150MP0003186_abnormal_redox_activity0.66012343
151MP0008469_abnormal_protein_level0.64787469
152MP0002098_abnormal_vibrissa_morphology0.63471016
153MP0001881_abnormal_mammary_gland0.62867179
154MP0010368_abnormal_lymphatic_system0.62807838
155MP0004782_abnormal_surfactant_physiolog0.62692086
156MP0000639_abnormal_adrenal_gland0.62336838
157MP0005023_abnormal_wound_healing0.62111248
158MP0003866_abnormal_defecation0.61850992
159MP0002933_joint_inflammation0.60628374
160MP0005535_abnormal_body_temperature0.58994452
161MP0002971_abnormal_brown_adipose0.58448636
162MP0002970_abnormal_white_adipose0.58080252
163MP0001764_abnormal_homeostasis0.56879186

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)6.56704077
2Hypoglycemic seizures (HP:0002173)6.20110206
3Hyperinsulinemic hypoglycemia (HP:0000825)6.19433958
4Symptomatic seizures (HP:0011145)5.31970051
5Hyperglycemia (HP:0003074)4.59873024
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.26744732
7Ketoacidosis (HP:0001993)4.22654260
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.20823186
9Insulin-resistant diabetes mellitus (HP:0000831)4.10764956
10Mucopolysacchariduria (HP:0008155)3.96035717
11Urinary glycosaminoglycan excretion (HP:0003541)3.96035717
12Late onset (HP:0003584)3.95276778
13Abnormality of the pancreatic islet cells (HP:0006476)3.83578606
14Abnormality of endocrine pancreas physiology (HP:0012093)3.83578606
15Acute lymphatic leukemia (HP:0006721)3.67435104
16Abnormality of the intrinsic pathway (HP:0010989)3.66011316
17Dysostosis multiplex (HP:0000943)3.63729588
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.58664099
19Abnormality of polysaccharide metabolism (HP:0011012)3.58664099
20Abnormality of glycosaminoglycan metabolism (HP:0004371)3.58664099
21Generalized aminoaciduria (HP:0002909)3.53001887
22Pancreatic islet-cell hyperplasia (HP:0004510)3.51270742
23Abnormality of macular pigmentation (HP:0008002)3.37260864
24Abnormality of the common coagulation pathway (HP:0010990)3.18689212
25Prolonged bleeding time (HP:0003010)3.17714986
26Metaphyseal dysplasia (HP:0100255)3.14726019
27Central scotoma (HP:0000603)3.13431817
28Ketosis (HP:0001946)3.11656422
29Insulin resistance (HP:0000855)3.09090512
30Dyschromatopsia (HP:0007641)3.06944215
31Acute myeloid leukemia (HP:0004808)3.05531792
32Dynein arm defect of respiratory motile cilia (HP:0012255)3.04820991
33Absent/shortened dynein arms (HP:0200106)3.04820991
34Intrahepatic cholestasis (HP:0001406)3.03555223
35Abnormal pancreas size (HP:0012094)3.02293141
36Autoimmune hemolytic anemia (HP:0001890)2.94522884
37Elevated erythrocyte sedimentation rate (HP:0003565)2.93088251
38Myositis (HP:0100614)2.92607589
39Abnormality of the prostate (HP:0008775)2.91771181
40Abnormality of B cell number (HP:0010975)2.87551337
41Large for gestational age (HP:0001520)2.85924599
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84339391
43Cone-rod dystrophy (HP:0000548)2.83263272
44Gout (HP:0001997)2.80854639
45Epistaxis (HP:0000421)2.77749115
46Abnormality of glycolipid metabolism (HP:0010969)2.76150560
47Abnormality of liposaccharide metabolism (HP:0010968)2.76150560
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.76150560
49Decreased central vision (HP:0007663)2.69526369
50Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67949466
51Conjugated hyperbilirubinemia (HP:0002908)2.67845130
52Vacuolated lymphocytes (HP:0001922)2.67482987
53Retinal atrophy (HP:0001105)2.64700946
54Abnormality of calcium-phosphate metabolism (HP:0100530)2.64075910
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.62733670
56B lymphocytopenia (HP:0010976)2.61592139
57Xanthomatosis (HP:0000991)2.59318126
58Thoracolumbar scoliosis (HP:0002944)2.58724074
59Abnormality of purine metabolism (HP:0004352)2.54771978
60Panhypogammaglobulinemia (HP:0003139)2.45833009
61Decreased circulating renin level (HP:0003351)2.45092795
62Hypokalemia (HP:0002900)2.42040833
63Thrombocytosis (HP:0001894)2.37716570
64Papilledema (HP:0001085)2.35566296
65Gingival bleeding (HP:0000225)2.34588323
66Encephalitis (HP:0002383)2.32979676
67Abnormal platelet function (HP:0011869)2.32291020
68Impaired platelet aggregation (HP:0003540)2.32291020
69Hyperactive renin-angiotensin system (HP:0000841)2.28732210
70Abdominal distention (HP:0003270)2.26867415
71Thickened calvaria (HP:0002684)2.26048503
72Thoracic kyphosis (HP:0002942)2.25083731
73Abnormal respiratory motile cilium morphology (HP:0005938)2.24773250
74Abnormal respiratory epithelium morphology (HP:0012253)2.24773250
75Chronic diarrhea (HP:0002028)2.24311062
76Abnormality of T cell number (HP:0011839)2.23220741
77Complement deficiency (HP:0004431)2.23068429
78Agammaglobulinemia (HP:0004432)2.22093885
79Stomatitis (HP:0010280)2.21599312
80Autoimmune thrombocytopenia (HP:0001973)2.18658525
81Deep venous thrombosis (HP:0002625)2.15031522
82Orchitis (HP:0100796)2.14235788
83Arterial thrombosis (HP:0004420)2.13343987
84Abnormal ciliary motility (HP:0012262)2.12985360
85Flat acetabular roof (HP:0003180)2.12899120
86Abnormality of T cells (HP:0002843)2.12520218
87Abnormal rod and cone electroretinograms (HP:0008323)2.12346770
88Chronic otitis media (HP:0000389)2.12335285
89Protuberant abdomen (HP:0001538)2.11174466
90Skin nodule (HP:0200036)2.11144555
91Pulmonary embolism (HP:0002204)2.10543389
92Prostate neoplasm (HP:0100787)2.10025209
93Vasculitis (HP:0002633)2.09953761
94Xerostomia (HP:0000217)2.09708184
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08837023
96Meningitis (HP:0001287)2.08183143
97Inflammation of the large intestine (HP:0002037)2.08096150
98T lymphocytopenia (HP:0005403)2.07891995
99Limb hypertonia (HP:0002509)2.06332235
100Progressive neurologic deterioration (HP:0002344)2.05769249
101Cervical subluxation (HP:0003308)2.05591044
102Exocrine pancreatic insufficiency (HP:0001738)2.04968474
103Abnormality of T cell physiology (HP:0011840)2.04874878
104Polygenic inheritance (HP:0010982)2.04649206
105Unilateral renal agenesis (HP:0000122)2.03856206
106Abolished electroretinogram (ERG) (HP:0000550)2.03811857
107Abnormality of chloride homeostasis (HP:0011422)2.02246692
108Abnormality of the periventricular white matter (HP:0002518)2.02220888
109Fat malabsorption (HP:0002630)2.02213448
110Spontaneous hematomas (HP:0007420)2.02087147
111Recurrent viral infections (HP:0004429)2.01719112
112Gastrointestinal infarctions (HP:0005244)2.01016442
113Joint swelling (HP:0001386)2.00421517
114Reduced antithrombin III activity (HP:0001976)1.99649100
115Abnormal biliary tract morphology (HP:0012440)1.99282590
116Pustule (HP:0200039)1.97959627
117Abnormal respiratory motile cilium physiology (HP:0012261)1.97805910
118Keratoconjunctivitis sicca (HP:0001097)1.94967129
119Alveolar cell carcinoma (HP:0006519)1.94087305
120Recurrent abscess formation (HP:0002722)1.92326166
121Abnormality of potassium homeostasis (HP:0011042)1.91227495
122Abnormality of fatty-acid metabolism (HP:0004359)1.90645058
123Abnormality of the distal phalanges of the toes (HP:0010182)1.90531990
124Eczematoid dermatitis (HP:0000976)1.90013384
125Abnormal enzyme/coenzyme activity (HP:0012379)1.88608468
126Menstrual irregularities (HP:0000858)1.88586142
127Recurrent skin infections (HP:0001581)1.87480323
128Gastrointestinal inflammation (HP:0004386)1.87141831
129Increased cerebral lipofuscin (HP:0011813)1.86862827
130Petechiae (HP:0000967)1.86158062
131Chronic obstructive pulmonary disease (HP:0006510)1.86013169
132Obstructive lung disease (HP:0006536)1.86013169
133Abnormality of alkaline phosphatase activity (HP:0004379)1.85214644
134Elevated alkaline phosphatase (HP:0003155)1.85031436
135Pulmonary infiltrates (HP:0002113)1.84963571
136Keratoconjunctivitis (HP:0001096)1.84927123
137Recurrent fungal infections (HP:0002841)1.84757358
138Hyperparathyroidism (HP:0000843)1.84708444
139Disinhibition (HP:0000734)1.84535027
140Retrobulbar optic neuritis (HP:0100654)1.84041430
141Optic neuritis (HP:0100653)1.84041430
142Beaking of vertebral bodies (HP:0004568)1.83812814
143Increased neuronal autofluorescent lipopigment (HP:0002074)1.83730823
144Abnormality of renin-angiotensin system (HP:0000847)1.82976290
145Osteomalacia (HP:0002749)1.80270475
146Hyperkalemia (HP:0002153)1.79903731
147Severe short stature (HP:0003510)1.79880960
148Neoplasm of the tracheobronchial system (HP:0100552)1.79682198
149Syringomyelia (HP:0003396)1.79362237
150Spinal cord lesions (HP:0100561)1.79362237
151Scotoma (HP:0000575)1.79287881
152Prolonged partial thromboplastin time (HP:0003645)1.78624153
153Aortic aneurysm (HP:0004942)1.78384942
154Urticaria (HP:0001025)1.78095044
155Hypophosphatemia (HP:0002148)1.77993637
156Macular degeneration (HP:0000608)1.77785818
157Chest pain (HP:0100749)1.77609382
158Prominent metopic ridge (HP:0005487)1.77483553
159Abnormality of the lumbar spine (HP:0100712)1.76612407
160Progressive visual loss (HP:0000529)1.76070893
161Growth hormone excess (HP:0000845)1.75155806
162Papillary thyroid carcinoma (HP:0002895)1.74438886
163Recurrent bronchitis (HP:0002837)1.73558617
164Abnormality of nucleobase metabolism (HP:0010932)1.73313808
165Pancreatitis (HP:0001733)1.73271946
166Increased CSF protein (HP:0002922)1.73232921
167Granulocytopenia (HP:0001913)1.72957771
168Cardiomegaly (HP:0001640)1.72553784
169Cerebral aneurysm (HP:0004944)1.72518571
170Thin bony cortex (HP:0002753)1.71918386
171Myoglobinuria (HP:0002913)1.70434628
172Hyperphosphatemia (HP:0002905)1.70174059
173Back pain (HP:0003418)1.68846688
174Right ventricular cardiomyopathy (HP:0011663)1.67867917
175Abnormality of glutamine family amino acid metabolism (HP:0010902)1.67799492
176Aneurysm (HP:0002617)1.67448620
177Macroorchidism (HP:0000053)1.67296797
178Irritability (HP:0000737)1.66666368
179Hypotension (HP:0002615)1.66206861
180Systemic lupus erythematosus (HP:0002725)1.65412369
181Hypokalemic alkalosis (HP:0001949)1.64767443
182Hypoplasia of the thymus (HP:0000778)1.63978276
183Acute hepatic failure (HP:0006554)1.62821906
184Agitation (HP:0000713)1.61915541
185Hyperbilirubinemia (HP:0002904)1.60704640
186Hyperuricemia (HP:0002149)1.59541098
187Increased purine levels (HP:0004368)1.59541098
188Asymmetric septal hypertrophy (HP:0001670)1.58451140
189Proximal tubulopathy (HP:0000114)1.58386255
190Mitral stenosis (HP:0001718)1.57871992
191Glomerulonephritis (HP:0000099)1.57499046
192Abnormal protein glycosylation (HP:0012346)1.57287861
193Abnormal glycosylation (HP:0012345)1.57287861
194Abnormal protein N-linked glycosylation (HP:0012347)1.57287861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.10180312
2PASK4.02362251
3ERN14.00960009
4MAPK153.37605322
5TAOK33.28470366
6KIT3.19217528
7TRIB32.73316661
8TXK2.68650413
9FRK2.63654888
10PBK2.45283904
11TAF12.30768825
12FLT32.24532024
13BCKDK2.16666636
14HIPK22.16261508
15FGFR42.11835817
16CSF1R2.05784548
17MAP3K22.05735065
18EPHA31.99167700
19SIK11.92963738
20MAP4K21.89238894
21PTK61.88964580
22MAP3K61.79142140
23MAP3K31.59967743
24IRAK31.59913010
25WNK41.56891037
26PDGFRA1.56454317
27PRKD31.54750741
28EPHA21.52470553
29TGFBR21.50956158
30PKN21.50425466
31BMPR21.49945165
32SCYL21.48890218
33MATK1.41584790
34NEK91.39586084
35PINK11.38516538
36WNK31.37216339
37RIPK41.36289457
38SYK1.34266016
39LATS11.28389251
40PTK21.28317908
41MAP3K131.28225388
42AKT31.27748153
43FGFR31.27186467
44PIK3CG1.26924607
45EPHB11.24714497
46FES1.13583514
47ZAP701.11809116
48JAK11.10828934
49JAK31.09705517
50RPS6KA41.09101916
51PRKCQ1.07150286
52ITK1.06927343
53IKBKE1.05127741
54RPS6KB21.02221544
55MAP2K61.01913326
56IRAK11.00904027
57GRK61.00396441
58DYRK1B0.99877348
59BRSK20.99661242
60IKBKB0.99150312
61MET0.99086906
62MAP3K10.97662588
63DAPK20.96190035
64TYK20.95304847
65NLK0.94706325
66JAK20.93196446
67EIF2AK20.91883820
68MKNK10.91748467
69FER0.91445343
70LCK0.90469114
71MAP3K100.89577408
72HCK0.88658613
73EIF2AK30.88077338
74CHUK0.86818767
75STK240.85586139
76TRPM70.82850555
77CLK10.80002772
78PIK3CA0.77295203
79STK100.76145433
80TESK10.75453457
81TBK10.73315700
82MAPKAPK30.72466664
83MAP2K20.71953823
84CDK190.71604862
85TEC0.69781621
86MTOR0.69292761
87MAPK70.67542121
88CDK60.66965352
89RET0.65561554
90RIPK10.64822921
91PRKCH0.64699064
92CDC42BPA0.64388224
93LYN0.64337253
94DAPK10.60117807
95MST1R0.59651648
96RPS6KL10.59430842
97RPS6KC10.59430842
98BTK0.58684526
99LRRK20.58590603
100CAMKK20.57386943
101MAP3K50.56503431
102PDK20.56376454
103GSK3A0.55880611
104CAMK1D0.53438167
105IGF1R0.53056706
106CSK0.52818296
107MAP3K70.52058962
108MAP2K30.51484761
109CDK120.51476240
110PAK30.50058115
111RPS6KA60.49862160
112ABL10.49799734
113TNK20.49737272
114STK30.48261970
115MAP4K10.46049596
116CDK90.45954318
117PDGFRB0.45566566
118STK390.45369314
119ACVR1B0.44266986
120TIE10.43602899
121PRKCD0.42789512
122RPS6KB10.41444380
123RAF10.40879122
124MST40.40772915
125KDR0.39832835
126MELK0.39818015
127TGFBR10.39800500
128PAK40.38583981
129MAP3K140.38052006
130PRKAA10.37950555
131ERBB30.37817712
132CDK30.37744915
133PRKG20.36856915
134PRKD20.36631743
135FGFR10.35761151
136STK38L0.35459355
137MAPK110.34895627
138BRD40.34640767
139NTRK10.33844694
140MAPK40.32596306
141GRK10.32197356
142MARK30.30619866
143MAPKAPK20.30172755
144IRAK40.29661902
145MAP2K10.29643189
146ERBB40.29342806
147PRKD10.27941678
148NUAK10.25958298
149PAK20.24840184

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.31230152
2Protein export_Homo sapiens_hsa030604.30457249
3Sulfur metabolism_Homo sapiens_hsa009203.31827756
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.18714194
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.66790495
6Allograft rejection_Homo sapiens_hsa053302.58560345
7Selenocompound metabolism_Homo sapiens_hsa004502.52495120
8Asthma_Homo sapiens_hsa053102.45226096
9Platelet activation_Homo sapiens_hsa046112.37308033
10Autoimmune thyroid disease_Homo sapiens_hsa053202.33721297
11Graft-versus-host disease_Homo sapiens_hsa053322.23431325
12Tryptophan metabolism_Homo sapiens_hsa003802.09624765
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96377294
14Leishmaniasis_Homo sapiens_hsa051401.87761361
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85858920
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.84873088
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79952157
18Folate biosynthesis_Homo sapiens_hsa007901.76352168
19Fatty acid degradation_Homo sapiens_hsa000711.72468691
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68278931
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68191641
22Other glycan degradation_Homo sapiens_hsa005111.65595406
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.59483978
24N-Glycan biosynthesis_Homo sapiens_hsa005101.58327236
25Renin secretion_Homo sapiens_hsa049241.58320936
26* Lysosome_Homo sapiens_hsa041421.57759912
27Hematopoietic cell lineage_Homo sapiens_hsa046401.57006256
28Nitrogen metabolism_Homo sapiens_hsa009101.53150094
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48354899
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48345763
31B cell receptor signaling pathway_Homo sapiens_hsa046621.47027290
32Starch and sucrose metabolism_Homo sapiens_hsa005001.38856610
33Measles_Homo sapiens_hsa051621.36638019
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34017939
35Primary immunodeficiency_Homo sapiens_hsa053401.30867741
36Salivary secretion_Homo sapiens_hsa049701.28897506
37Acute myeloid leukemia_Homo sapiens_hsa052211.27836267
38ABC transporters_Homo sapiens_hsa020101.26936807
39Insulin resistance_Homo sapiens_hsa049311.26870591
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26516076
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24168303
42Arachidonic acid metabolism_Homo sapiens_hsa005901.22925816
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21175915
44Complement and coagulation cascades_Homo sapiens_hsa046101.16740902
45Histidine metabolism_Homo sapiens_hsa003401.15651431
46Antigen processing and presentation_Homo sapiens_hsa046121.15560864
47African trypanosomiasis_Homo sapiens_hsa051431.15449056
48Herpes simplex infection_Homo sapiens_hsa051681.14272896
49Fatty acid metabolism_Homo sapiens_hsa012121.11924045
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11008132
51Peroxisome_Homo sapiens_hsa041461.09357204
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08392988
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.08344592
54Sphingolipid metabolism_Homo sapiens_hsa006001.08193083
55Type II diabetes mellitus_Homo sapiens_hsa049301.07857878
56Insulin secretion_Homo sapiens_hsa049111.07802356
57Rheumatoid arthritis_Homo sapiens_hsa053231.07655656
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07006200
59Phenylalanine metabolism_Homo sapiens_hsa003601.06536056
60Long-term depression_Homo sapiens_hsa047301.04844318
61Fat digestion and absorption_Homo sapiens_hsa049751.02389054
62Hepatitis C_Homo sapiens_hsa051601.02144083
63Butanoate metabolism_Homo sapiens_hsa006501.01185973
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.99709006
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98674447
66Tuberculosis_Homo sapiens_hsa051520.98290292
67Propanoate metabolism_Homo sapiens_hsa006400.97440937
68Galactose metabolism_Homo sapiens_hsa000520.97427259
69Lysine degradation_Homo sapiens_hsa003100.96622004
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.95824404
71Osteoclast differentiation_Homo sapiens_hsa043800.95350580
72Vibrio cholerae infection_Homo sapiens_hsa051100.93820930
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93544817
74Legionellosis_Homo sapiens_hsa051340.92491146
75Caffeine metabolism_Homo sapiens_hsa002320.92367831
76TNF signaling pathway_Homo sapiens_hsa046680.91643278
77Influenza A_Homo sapiens_hsa051640.90470529
78Type I diabetes mellitus_Homo sapiens_hsa049400.90214579
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89909974
80Ether lipid metabolism_Homo sapiens_hsa005650.87582638
81PPAR signaling pathway_Homo sapiens_hsa033200.86133525
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82656164
83T cell receptor signaling pathway_Homo sapiens_hsa046600.82540382
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82485314
85Staphylococcus aureus infection_Homo sapiens_hsa051500.80640663
86Tyrosine metabolism_Homo sapiens_hsa003500.76346503
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75081513
88Prion diseases_Homo sapiens_hsa050200.72240438
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71314798
90Circadian rhythm_Homo sapiens_hsa047100.69911953
91Glucagon signaling pathway_Homo sapiens_hsa049220.69249658
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68533468
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.65883642
94beta-Alanine metabolism_Homo sapiens_hsa004100.65815443
95Chemical carcinogenesis_Homo sapiens_hsa052040.65391501
96Thyroid hormone synthesis_Homo sapiens_hsa049180.65323446
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.64972089
98Prolactin signaling pathway_Homo sapiens_hsa049170.64832599
99Glutathione metabolism_Homo sapiens_hsa004800.63671705
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63022325
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63004643
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62992281
103Inositol phosphate metabolism_Homo sapiens_hsa005620.61922720
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.61670680
105Chemokine signaling pathway_Homo sapiens_hsa040620.60847584
106Pancreatic cancer_Homo sapiens_hsa052120.59967773
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59723210
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59517999
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59469057
110Arginine biosynthesis_Homo sapiens_hsa002200.59273288
111Amoebiasis_Homo sapiens_hsa051460.58544587
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58312671
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58070719
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57714218
115Ovarian steroidogenesis_Homo sapiens_hsa049130.53873453
116Pertussis_Homo sapiens_hsa051330.53396413
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.52848937
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52391111
119Protein digestion and absorption_Homo sapiens_hsa049740.51807321
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51198446
121Bile secretion_Homo sapiens_hsa049760.51060378
122Regulation of autophagy_Homo sapiens_hsa041400.51025431
123Pyruvate metabolism_Homo sapiens_hsa006200.49654467
124Adherens junction_Homo sapiens_hsa045200.48608055
125Malaria_Homo sapiens_hsa051440.48259892
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.46910623
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45567936
128Insulin signaling pathway_Homo sapiens_hsa049100.44750802
129AMPK signaling pathway_Homo sapiens_hsa041520.44049731
130Vitamin digestion and absorption_Homo sapiens_hsa049770.42230659
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41677854
132Thyroid cancer_Homo sapiens_hsa052160.41458757
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40730846
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39343381
135Fatty acid elongation_Homo sapiens_hsa000620.37922002
136Retinol metabolism_Homo sapiens_hsa008300.37087487
137Renin-angiotensin system_Homo sapiens_hsa046140.36756667
138Carbon metabolism_Homo sapiens_hsa012000.36165905
139Prostate cancer_Homo sapiens_hsa052150.35713119
140Pancreatic secretion_Homo sapiens_hsa049720.35571075
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32628805
142Arginine and proline metabolism_Homo sapiens_hsa003300.31740868
143Toxoplasmosis_Homo sapiens_hsa051450.31619896
144Glycerolipid metabolism_Homo sapiens_hsa005610.30816493
145Bladder cancer_Homo sapiens_hsa052190.29523304
146FoxO signaling pathway_Homo sapiens_hsa040680.28303526
147Fructose and mannose metabolism_Homo sapiens_hsa000510.25671576
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25372042
149Cocaine addiction_Homo sapiens_hsa050300.25100309
150Linoleic acid metabolism_Homo sapiens_hsa005910.25099751
151mTOR signaling pathway_Homo sapiens_hsa041500.23423015
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22588012
153Chronic myeloid leukemia_Homo sapiens_hsa052200.22393149
1542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22136166
155NF-kappa B signaling pathway_Homo sapiens_hsa040640.20291991
156Focal adhesion_Homo sapiens_hsa045100.20207466
157One carbon pool by folate_Homo sapiens_hsa006700.19630933

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