CD163

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.70199407
2complement activation, alternative pathway (GO:0006957)5.56146710
3positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.46528046
4immunoglobulin mediated immune response (GO:0016064)5.43895936
5response to peptidoglycan (GO:0032494)5.18652907
6positive regulation of cholesterol efflux (GO:0010875)5.08444733
7negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.88030533
8pinocytosis (GO:0006907)4.86650015
9negative regulation of B cell apoptotic process (GO:0002903)4.84380060
10cellular extravasation (GO:0045123)4.81020466
11positive regulation of sterol transport (GO:0032373)4.70906507
12positive regulation of cholesterol transport (GO:0032376)4.70906507
13cellular response to thyroid hormone stimulus (GO:0097067)4.57690695
14negative regulation of granulocyte differentiation (GO:0030853)4.48868016
15regulation of complement activation (GO:0030449)4.39958491
16regulation of protein activation cascade (GO:2000257)4.36313679
17regulation of cholesterol storage (GO:0010885)4.27429826
18folic acid transport (GO:0015884)4.25311935
19macroautophagy (GO:0016236)4.23023825
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21618177
21complement activation (GO:0006956)4.20113453
22glycosphingolipid catabolic process (GO:0046479)4.15412087
23positive regulation of gamma-delta T cell activation (GO:0046645)4.13146204
24positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.05220483
25regulation of B cell apoptotic process (GO:0002902)4.01377124
26germinal center formation (GO:0002467)3.92617127
27lipopolysaccharide-mediated signaling pathway (GO:0031663)3.92037748
28positive regulation of triglyceride lipase activity (GO:0061365)3.89818699
29positive regulation of lipoprotein lipase activity (GO:0051006)3.89818699
30detection of molecule of bacterial origin (GO:0032490)3.87351372
31amino sugar catabolic process (GO:0046348)3.83560948
32regulation of interleukin-8 biosynthetic process (GO:0045414)3.82660823
33complement activation, classical pathway (GO:0006958)3.81826404
34regulation of macrophage chemotaxis (GO:0010758)3.81095310
35B cell mediated immunity (GO:0019724)3.78996364
36oligosaccharide catabolic process (GO:0009313)3.75356232
37glycolipid catabolic process (GO:0019377)3.71682886
38regulation of cholesterol homeostasis (GO:2000188)3.70596058
39T-helper 1 type immune response (GO:0042088)3.69924083
40basic amino acid transport (GO:0015802)3.69864198
41transcytosis (GO:0045056)3.64697445
42negative regulation of type 2 immune response (GO:0002829)3.61671033
43negative regulation of lipid storage (GO:0010888)3.60368020
44triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.59354674
45amyloid precursor protein catabolic process (GO:0042987)3.59076748
46regulation of macrophage derived foam cell differentiation (GO:0010743)3.58846256
47lymphocyte chemotaxis (GO:0048247)3.52527458
48apoptotic cell clearance (GO:0043277)3.49582853
49positive regulation of mast cell activation involved in immune response (GO:0033008)3.48758667
50positive regulation of mast cell degranulation (GO:0043306)3.48758667
51regulation of T-helper 2 cell differentiation (GO:0045628)3.48450500
52regulation of mast cell degranulation (GO:0043304)3.46526785
53N-acetylneuraminate metabolic process (GO:0006054)3.45932251
54negative regulation of digestive system process (GO:0060457)3.44860793
55protein activation cascade (GO:0072376)3.44734968
56mast cell degranulation (GO:0043303)3.44532907
57mast cell activation involved in immune response (GO:0002279)3.44532907
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41004457
59macrophage activation (GO:0042116)3.40401651
60regulation of vitamin D biosynthetic process (GO:0060556)3.39997864
61positive regulation of monocyte chemotaxis (GO:0090026)3.39973053
62positive regulation of chemokine biosynthetic process (GO:0045080)3.39234500
63macrophage activation involved in immune response (GO:0002281)3.36279523
64mast cell activation (GO:0045576)3.36268030
65regulation of cholesterol efflux (GO:0010874)3.35068013
66ceramide catabolic process (GO:0046514)3.32382595
67regulation of memory T cell differentiation (GO:0043380)3.32184485
68monocyte chemotaxis (GO:0002548)3.30551828
69granulocyte activation (GO:0036230)3.29371521
70negative regulation of cell killing (GO:0031342)3.29369974
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.29369974
72phospholipid efflux (GO:0033700)3.28695629
73negative regulation of cytokine production involved in immune response (GO:0002719)3.27690477
74positive regulation of mast cell activation (GO:0033005)3.27084327
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.25880905
76regulation of podosome assembly (GO:0071801)3.25751640
77detection of other organism (GO:0098543)3.24041859
78negative regulation of erythrocyte differentiation (GO:0045647)3.23956592
79positive regulation of leukocyte degranulation (GO:0043302)3.23758524
80interferon-gamma-mediated signaling pathway (GO:0060333)3.22956773
81regulation of mast cell activation involved in immune response (GO:0033006)3.22708656
82positive regulation of cellular amide metabolic process (GO:0034250)3.22658767
83detection of external biotic stimulus (GO:0098581)3.21316064
84alpha-linolenic acid metabolic process (GO:0036109)3.21149873
85respiratory burst (GO:0045730)3.21026817
86negative regulation of immunoglobulin mediated immune response (GO:0002890)3.20356862
87negative regulation of B cell mediated immunity (GO:0002713)3.20356862
88positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.19155506
89regulation of interferon-beta biosynthetic process (GO:0045357)3.16653109
90production of molecular mediator involved in inflammatory response (GO:0002532)3.15066380
91fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13936976
92T cell migration (GO:0072678)3.13408160
93neutrophil activation involved in immune response (GO:0002283)3.12453057
94L-phenylalanine catabolic process (GO:0006559)3.11909320
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.11909320
96urea metabolic process (GO:0019627)3.10853262
97urea cycle (GO:0000050)3.10853262
98regulation of cytokine secretion involved in immune response (GO:0002739)3.09827756
99plasma lipoprotein particle clearance (GO:0034381)3.09197091
100eosinophil chemotaxis (GO:0048245)3.08839994
101aromatic amino acid family catabolic process (GO:0009074)3.06990535
102negative regulation of macroautophagy (GO:0016242)3.05789693
103negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.05302738
104protein carboxylation (GO:0018214)3.05214862
105peptidyl-glutamic acid carboxylation (GO:0017187)3.05214862
106lipoxygenase pathway (GO:0019372)3.05076411
107negative regulation of myeloid cell apoptotic process (GO:0033033)3.03464390
108regulation of leukocyte degranulation (GO:0043300)3.02820118
109negative regulation of nitric oxide biosynthetic process (GO:0045019)3.02400972
110triglyceride homeostasis (GO:0070328)3.02353413
111acylglycerol homeostasis (GO:0055090)3.02353413
112myeloid dendritic cell differentiation (GO:0043011)3.01702050
113myeloid cell activation involved in immune response (GO:0002275)3.01700199
114tryptophan catabolic process (GO:0006569)3.01318950
115indole-containing compound catabolic process (GO:0042436)3.01318950
116indolalkylamine catabolic process (GO:0046218)3.01318950
117regulation of myeloid leukocyte mediated immunity (GO:0002886)3.00610669
118regulation of sterol transport (GO:0032371)2.99351235
119regulation of cholesterol transport (GO:0032374)2.99351235
120positive regulation of triglyceride biosynthetic process (GO:0010867)2.98514597
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.98130083
122adhesion of symbiont to host cell (GO:0044650)2.97975880
123virion attachment to host cell (GO:0019062)2.97975880
124regulation of mononuclear cell migration (GO:0071675)2.97759866
125membrane lipid catabolic process (GO:0046466)2.95997215
126regulation of mast cell activation (GO:0033003)2.95300576
127regulation of interferon-alpha production (GO:0032647)2.94452245
128positive regulation of antigen processing and presentation (GO:0002579)2.94168982
129positive regulation of heat generation (GO:0031652)2.92540290
130microglial cell activation (GO:0001774)2.92483792
131regulation of gamma-delta T cell activation (GO:0046643)2.92390699
132negative regulation of protein activation cascade (GO:2000258)2.91855008
133regulation of germinal center formation (GO:0002634)2.91453292
134regulation of antigen processing and presentation (GO:0002577)2.91171821
135regulation of chemokine biosynthetic process (GO:0045073)2.90372088
136regulation of cholesterol esterification (GO:0010872)2.89801785
137neutrophil activation (GO:0042119)2.89579039
138positive regulation of smooth muscle cell migration (GO:0014911)2.88867053
139barbed-end actin filament capping (GO:0051016)2.88702132
140positive regulation by symbiont of host defense response (GO:0052509)2.88478197
141modulation by symbiont of host defense response (GO:0052031)2.88478197
142modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88478197
143modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88478197
144positive regulation by organism of defense response of other organism involved in symbiotic interact2.88478197
145modulation by symbiont of host immune response (GO:0052553)2.88478197
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87267926
147positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86763745
148detection of bacterium (GO:0016045)2.86530233
149phospholipid homeostasis (GO:0055091)2.85900269
150detection of biotic stimulus (GO:0009595)2.85761892
151low-density lipoprotein particle clearance (GO:0034383)2.85657737
152low-density lipoprotein particle remodeling (GO:0034374)2.84237920
153erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.84043958
154L-phenylalanine metabolic process (GO:0006558)2.84043958
155response to muramyl dipeptide (GO:0032495)2.83994883
156regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.83125475
157NIK/NF-kappaB signaling (GO:0038061)2.82795662
158antigen processing and presentation of endogenous antigen (GO:0019883)2.81719225
159nitrogen cycle metabolic process (GO:0071941)2.81049289
160regulation of triglyceride biosynthetic process (GO:0010866)2.80719302
161hydrogen peroxide biosynthetic process (GO:0050665)2.79919203
162cellular response to lipopolysaccharide (GO:0071222)2.79579892
163regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79545157
164macrophage differentiation (GO:0030225)2.79255602
165eosinophil migration (GO:0072677)2.78841364
166sphingolipid catabolic process (GO:0030149)2.78650385
167response to thyroid hormone (GO:0097066)2.78565033
168tryptophan metabolic process (GO:0006568)2.78353386
169myeloid dendritic cell activation (GO:0001773)2.77437560
170cellular response to molecule of bacterial origin (GO:0071219)2.75341204
171positive regulation of type 2 immune response (GO:0002830)2.73842702
172defense response to protozoan (GO:0042832)2.72472630
173regulation of interleukin-12 production (GO:0032655)2.71739913
174response to host immune response (GO:0052572)2.70762679
175response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70762679
176regulation of membrane protein ectodomain proteolysis (GO:0051043)2.70171541
177regulation of T cell tolerance induction (GO:0002664)2.69805066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.38393096
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.32490900
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.08488172
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.97207884
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.93171975
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.80270008
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.76899232
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63410461
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.48461849
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.45348946
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.21825373
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.09298087
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.95253624
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88937522
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.66812389
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53127529
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.43069922
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36671052
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36017722
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34196075
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.29718214
22CLOCK_20551151_ChIP-Seq_293T_Human2.28088019
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24699933
24SCL_19346495_ChIP-Seq_HPC-7_Human2.24007715
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19227891
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08936928
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00413475
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.95705845
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95105913
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94629369
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94282648
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90096366
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86881653
34RUNX_20019798_ChIP-Seq_JUKART_Human1.83912838
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78038339
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77262205
37VDR_24787735_ChIP-Seq_THP-1_Human1.75360701
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72182942
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71674068
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70843511
41GATA1_22025678_ChIP-Seq_K562_Human1.69254692
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68941797
43SPI1_23127762_ChIP-Seq_K562_Human1.67462271
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60601464
45VDR_24763502_ChIP-Seq_THP-1_Human1.55242047
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.50053905
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47274608
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40427915
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39489306
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.38552570
51PU_27001747_Chip-Seq_BMDM_Mouse1.37079604
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36726751
53LXR_22292898_ChIP-Seq_THP-1_Human1.35049145
54GATA1_19941826_ChIP-Seq_K562_Human1.31579767
55VDR_21846776_ChIP-Seq_THP-1_Human1.31481515
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.31103285
57MAF_26560356_Chip-Seq_TH1_Human1.29525702
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.25369027
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22299994
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.21807969
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.21523863
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21330000
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19718779
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18427762
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18254946
66GATA2_19941826_ChIP-Seq_K562_Human1.16395071
67EGR1_19032775_ChIP-ChIP_M12_Human1.15593961
68* SPI1_23547873_ChIP-Seq_NB4_Human1.12503945
69MYB_26560356_Chip-Seq_TH2_Human1.11924836
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11393423
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11384292
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10810006
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10054805
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09470258
75STAT1_20625510_ChIP-Seq_HELA_Human1.08384993
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06975630
77TFEB_21752829_ChIP-Seq_HELA_Human1.05397390
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.01803688
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01705627
80KDM2B_26808549_Chip-Seq_DND41_Human1.01135150
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00801216
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99907282
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99367407
84EGR1_19374776_ChIP-ChIP_THP-1_Human0.97679504
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94239560
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93902498
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92710764
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92233732
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92060201
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.91973799
91GATA3_26560356_Chip-Seq_TH2_Human0.91317182
92NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91083322
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89865601
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89734338
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89592389
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89296063
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89296063
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88296175
99UTX_26944678_Chip-Seq_JUKART_Human0.88214705
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87813806
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87222739
102SPI1_20517297_ChIP-Seq_HL60_Human0.86949201
103TCF7_22412390_ChIP-Seq_EML_Mouse0.86736309
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86057037
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85707753
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85563668
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84262955
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83552886
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83104425
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82603504
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82533565
112GATA3_27048872_Chip-Seq_THYMUS_Human0.82116663
113CJUN_26792858_Chip-Seq_BT549_Human0.81798766
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81584011
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80518293
116BCOR_27268052_Chip-Seq_Bcells_Human0.80249467
117* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79931921
118BCL6_27268052_Chip-Seq_Bcells_Human0.79310106
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.78227900
120MYB_26560356_Chip-Seq_TH1_Human0.77707999
121TP53_16413492_ChIP-PET_HCT116_Human0.76678697
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75858972
123KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75639832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.41077484
2MP0003191_abnormal_cellular_cholesterol4.83462806
3MP0005365_abnormal_bile_salt3.47130838
4MP0005058_abnormal_lysosome_morphology2.94948934
5MP0003436_decreased_susceptibility_to2.94653887
6MP0009840_abnormal_foam_cell2.94351333
7MP0001835_abnormal_antigen_presentation2.86739492
8MP0003172_abnormal_lysosome_physiology2.83070167
9MP0005360_urolithiasis2.75061462
10MP0010329_abnormal_lipoprotein_level2.60779768
11MP0003724_increased_susceptibility_to2.50612120
12MP0002148_abnormal_hypersensitivity_rea2.45102430
13MP0000604_amyloidosis2.42636934
14MP0001853_heart_inflammation2.41879420
15MP0002419_abnormal_innate_immunity2.40333201
16MP0000685_abnormal_immune_system2.37805397
17MP0005085_abnormal_gallbladder_physiolo2.36514168
18MP0005670_abnormal_white_adipose2.17610222
19MP0009278_abnormal_bone_marrow2.06861025
20MP0003690_abnormal_glial_cell1.96886191
21MP0005025_abnormal_response_to1.92682688
22MP0001800_abnormal_humoral_immune1.89852936
23MP0003303_peritoneal_inflammation1.89445960
24MP0003329_amyloid_beta_deposits1.86496026
25MP0001790_abnormal_immune_system1.86333800
26MP0005387_immune_system_phenotype1.86333800
27MP0005000_abnormal_immune_tolerance1.83782025
28MP0005671_abnormal_response_to1.82167379
29MP0003828_pulmonary_edema1.80933252
30MP0000609_abnormal_liver_physiology1.79842536
31MP0008875_abnormal_xenobiotic_pharmacok1.79686138
32MP0001533_abnormal_skeleton_physiology1.77807154
33MP0009785_altered_susceptibility_to1.77055990
34MP0002254_reproductive_system_inflammat1.76704305
35MP0005464_abnormal_platelet_physiology1.73375566
36MP0002452_abnormal_antigen_presenting1.66295500
37MP0008469_abnormal_protein_level1.62463576
38MP0000343_altered_response_to1.60207914
39MP0008004_abnormal_stomach_pH1.51867359
40MP0003448_altered_tumor_morphology1.51421826
41MP0003075_altered_response_to1.50930940
42MP0005451_abnormal_body_composition1.50305617
43MP0003252_abnormal_bile_duct1.49256081
44MP0002723_abnormal_immune_serum1.48281256
45MP0008438_abnormal_cutaneous_collagen1.46288913
46MP0002118_abnormal_lipid_homeostasis1.44984956
47MP0010368_abnormal_lymphatic_system1.44588489
48MP0001845_abnormal_inflammatory_respons1.42978240
49MP0005319_abnormal_enzyme/_coenzyme1.40440645
50MP0001727_abnormal_embryo_implantation1.36064799
51MP0006054_spinal_hemorrhage1.34901741
52MP0002420_abnormal_adaptive_immunity1.33056537
53MP0001819_abnormal_immune_cell1.32486233
54MP0000858_altered_metastatic_potential1.31266659
55MP0002138_abnormal_hepatobiliary_system1.30000609
56MP0002405_respiratory_system_inflammati1.29425032
57MP0003453_abnormal_keratinocyte_physiol1.28776913
58MP0009763_increased_sensitivity_to1.23146482
59MP0005332_abnormal_amino_acid1.22489535
60MP0002876_abnormal_thyroid_physiology1.22044134
61MP0004130_abnormal_muscle_cell1.19131695
62MP0010155_abnormal_intestine_physiology1.19000245
63MP0003806_abnormal_nucleotide_metabolis1.15635808
64MP0009333_abnormal_splenocyte_physiolog1.15458444
65MP0003656_abnormal_erythrocyte_physiolo1.15337522
66MP0002837_dystrophic_cardiac_calcinosis1.10152715
67MP0003705_abnormal_hypodermis_morpholog1.08974156
68MP0008260_abnormal_autophagy1.07485049
69MP0005584_abnormal_enzyme/coenzyme_acti1.06108691
70MP0004019_abnormal_vitamin_homeostasis1.05338523
71MP0005083_abnormal_biliary_tract1.03696922
72MP0005666_abnormal_adipose_tissue1.01412098
73MP0001666_abnormal_nutrient_absorption0.98951299
74MP0004510_myositis0.97644180
75MP0002396_abnormal_hematopoietic_system0.97186537
76MP0005334_abnormal_fat_pad0.97059039
77MP0003183_abnormal_peptide_metabolism0.96264473
78MP0009764_decreased_sensitivity_to0.94357925
79MP0002166_altered_tumor_susceptibility0.93722183
80MP0005647_abnormal_sex_gland0.93633589
81MP0005166_decreased_susceptibility_to0.92793610
82MP0003279_aneurysm0.92229061
83MP0001542_abnormal_bone_strength0.90617851
84MP0000249_abnormal_blood_vessel0.88809316
85MP0003300_gastrointestinal_ulcer0.88561754
86MP0005165_increased_susceptibility_to0.87589845
87MP0000598_abnormal_liver_morphology0.87248393
88MP0005275_abnormal_skin_tensile0.87185970
89MP0001764_abnormal_homeostasis0.86068078
90MP0002332_abnormal_exercise_endurance0.84398567
91MP0000689_abnormal_spleen_morphology0.84276198
92MP0009643_abnormal_urine_homeostasis0.84197803
93MP0005167_abnormal_blood-brain_barrier0.81804579
94MP0003795_abnormal_bone_structure0.80653585
95MP0002295_abnormal_pulmonary_circulatio0.80425305
96MP0000716_abnormal_immune_system0.79590443
97MP0002998_abnormal_bone_remodeling0.79218382
98MP0003045_fibrosis0.79189540
99MP0005164_abnormal_response_to0.79152407
100MP0000920_abnormal_myelination0.77696268
101MP0003195_calcinosis0.77614447
102MP0009642_abnormal_blood_homeostasis0.76893079
103MP0004947_skin_inflammation0.76831966
104MP0005310_abnormal_salivary_gland0.76413790
105MP0003091_abnormal_cell_migration0.75837404
106MP0004883_abnormal_blood_vessel0.75029390
107MP0006082_CNS_inflammation0.73166466
108MP0002933_joint_inflammation0.72455255
109MP0005595_abnormal_vascular_smooth0.72447227
110MP0002398_abnormal_bone_marrow0.72294979
111MP0002060_abnormal_skin_morphology0.71720369
112MP0003632_abnormal_nervous_system0.71662487
113MP0001663_abnormal_digestive_system0.71110296
114MP0002277_abnormal_respiratory_mucosa0.70782606
115MP0005535_abnormal_body_temperature0.70681852
116MP0001545_abnormal_hematopoietic_system0.70524203
117MP0005397_hematopoietic_system_phenotyp0.70524203
118MP0005023_abnormal_wound_healing0.69358623
119MP0002136_abnormal_kidney_physiology0.68947799
120MP0000465_gastrointestinal_hemorrhage0.68784067
121MP0005390_skeleton_phenotype0.68124754
122MP0003186_abnormal_redox_activity0.67994373
123MP0009765_abnormal_xenobiotic_induced0.67967619
124MP0008874_decreased_physiological_sensi0.67263355
125MP0002722_abnormal_immune_system0.67054575
126MP0003634_abnormal_glial_cell0.66576114
127MP0002090_abnormal_vision0.65848139
128MP0002429_abnormal_blood_cell0.65779212
129MP0001851_eye_inflammation0.65254177
130MP0003633_abnormal_nervous_system0.61109503
131MP0000371_diluted_coat_color0.58027643
132MP0005257_abnormal_intraocular_pressure0.55819170
133MP0002877_abnormal_melanocyte_morpholog0.55792428
134MP0010307_abnormal_tumor_latency0.54590434

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)8.20405184
2Glomerulonephritis (HP:0000099)8.02837841
3Abnormality of complement system (HP:0005339)7.40902768
4Recurrent abscess formation (HP:0002722)5.25731890
5Recurrent bacterial skin infections (HP:0005406)5.14331170
6Nephritis (HP:0000123)4.67413089
7Recurrent gram-negative bacterial infections (HP:0005420)4.57710991
8Disinhibition (HP:0000734)4.54230057
9Mutism (HP:0002300)4.40099276
10Loss of speech (HP:0002371)4.32914341
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.32850875
12Joint hemorrhage (HP:0005261)4.32018984
13Vacuolated lymphocytes (HP:0001922)4.25709365
14Increased cerebral lipofuscin (HP:0011813)4.18163779
15Eczematoid dermatitis (HP:0000976)3.99070004
16Abnormality of polysaccharide metabolism (HP:0011012)3.86626440
17Abnormality of glycosaminoglycan metabolism (HP:0004371)3.86626440
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.86626440
19Abnormality of the common coagulation pathway (HP:0010990)3.67791844
20Urinary glycosaminoglycan excretion (HP:0003541)3.63239818
21Mucopolysacchariduria (HP:0008155)3.63239818
22Orchitis (HP:0100796)3.62393121
23Xanthomatosis (HP:0000991)3.54708177
24Thick nail (HP:0001805)3.54444849
25Neurofibrillary tangles (HP:0002185)3.53971738
26Myocardial infarction (HP:0001658)3.53198535
27Spontaneous hematomas (HP:0007420)3.53125331
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.53069725
29Optic neuritis (HP:0100653)3.43138078
30Retrobulbar optic neuritis (HP:0100654)3.43138078
31Hypoalphalipoproteinemia (HP:0003233)3.25116049
32Abnormality of the vasculature of the conjunctiva (HP:0008054)3.20576012
33Deep venous thrombosis (HP:0002625)3.18987508
34Autoimmune thrombocytopenia (HP:0001973)3.18694051
35Nuclear cataract (HP:0100018)3.17049884
36Osteolytic defects of the phalanges of the hand (HP:0009771)3.13746636
37Osteolytic defects of the hand bones (HP:0009699)3.13746636
38Mediastinal lymphadenopathy (HP:0100721)3.04727511
39Stomatitis (HP:0010280)3.04021081
40Prolonged partial thromboplastin time (HP:0003645)3.02473883
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.91126693
42Axonal loss (HP:0003447)2.83995573
43Recurrent skin infections (HP:0001581)2.82589378
44Gingivitis (HP:0000230)2.81594163
45Increased serum ferritin (HP:0003281)2.77501535
46Cellulitis (HP:0100658)2.74416834
47Petechiae (HP:0000967)2.73132647
48Amyloidosis (HP:0011034)2.69597203
49Pustule (HP:0200039)2.69362844
50Neuronal loss in central nervous system (HP:0002529)2.66841016
51Apathy (HP:0000741)2.65388175
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63626815
53Diminished motivation (HP:0000745)2.63529961
54Inappropriate behavior (HP:0000719)2.60946182
55Progressive visual loss (HP:0000529)2.60427442
56Agnosia (HP:0010524)2.58879905
57Hyperlipoproteinemia (HP:0010980)2.58654792
58Hypolipoproteinemia (HP:0010981)2.53466635
59Intrahepatic cholestasis (HP:0001406)2.51359563
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.50743893
61Retinal atrophy (HP:0001105)2.48682989
62Cerebral inclusion bodies (HP:0100314)2.48135418
63Colitis (HP:0002583)2.46681863
64Pulmonary infiltrates (HP:0002113)2.44303316
65Mitral stenosis (HP:0001718)2.42326999
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.39929761
67Keratoconjunctivitis sicca (HP:0001097)2.38161108
68Periodontitis (HP:0000704)2.37377927
69Skin nodule (HP:0200036)2.37315639
70Hemoptysis (HP:0002105)2.36128188
71Prostate neoplasm (HP:0100787)2.35014680
72Metaphyseal irregularity (HP:0003025)2.33417288
73Progressive neurologic deterioration (HP:0002344)2.31101830
74Abnormality of iron homeostasis (HP:0011031)2.29933592
75Epidermoid cyst (HP:0200040)2.23874167
76Asymmetric septal hypertrophy (HP:0001670)2.23851690
77Gingival bleeding (HP:0000225)2.16874388
78Keratoconjunctivitis (HP:0001096)2.15836552
79Polyneuropathy (HP:0001271)2.13467914
80Dementia (HP:0000726)2.12735996
81Epistaxis (HP:0000421)2.12453447
82Hepatosplenomegaly (HP:0001433)2.12280067
83Conjunctival telangiectasia (HP:0000524)2.11901877
84Hematochezia (HP:0002573)2.10899805
85Malnutrition (HP:0004395)2.08245233
86Personality changes (HP:0000751)2.07133906
87Abnormality of the prostate (HP:0008775)2.07038457
88Hypokinesia (HP:0002375)2.06959538
89Vasculitis (HP:0002633)2.05930623
90Abnormality of fatty-acid metabolism (HP:0004359)2.04151040
91Upper motor neuron abnormality (HP:0002127)2.03668179
92Purpura (HP:0000979)2.02808479
93Alopecia of scalp (HP:0002293)2.02722068
94Basal ganglia calcification (HP:0002135)2.02378921
95Hyperglycinuria (HP:0003108)2.00126889
96Systemic lupus erythematosus (HP:0002725)10.4509675
97Elevated erythrocyte sedimentation rate (HP:0003565)1.99373993
98Memory impairment (HP:0002354)1.97677180
99Abolished electroretinogram (ERG) (HP:0000550)1.96395280
100Hypercholesterolemia (HP:0003124)1.95910493
101Abnormality of the periventricular white matter (HP:0002518)1.93412386
102Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93031244
103Abnormality of serine family amino acid metabolism (HP:0010894)1.92457952
104Abnormality of glycine metabolism (HP:0010895)1.92457952
105Pulmonary embolism (HP:0002204)1.91874774
106Increased connective tissue (HP:0009025)1.91712337
107Dysostosis multiplex (HP:0000943)1.90833187
108Hypobetalipoproteinemia (HP:0003563)1.89751057
109Abnormality of the peritoneum (HP:0002585)1.88954948
110Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88103380
111Abnormality of transition element cation homeostasis (HP:0011030)1.87781235
112Peripheral demyelination (HP:0011096)1.86009426
113Global brain atrophy (HP:0002283)1.85230742
114Abnormality of the intrinsic pathway (HP:0010989)1.84134368
115Hypertriglyceridemia (HP:0002155)1.83397776
116Supranuclear gaze palsy (HP:0000605)1.82777868
117Thoracic kyphosis (HP:0002942)1.81378898
118Hyperammonemia (HP:0001987)1.81063111
119Increased CSF protein (HP:0002922)1.80947414
120Cardiomegaly (HP:0001640)1.79908001
121Meningitis (HP:0001287)1.78391372
122Premature loss of primary teeth (HP:0006323)1.77882634
123Abnormality of methionine metabolism (HP:0010901)1.76914060
124Bone pain (HP:0002653)1.74553249
125T lymphocytopenia (HP:0005403)1.74431934
126Prolonged bleeding time (HP:0003010)1.73760302
127Vertigo (HP:0002321)1.73110652
128Pathologic fracture (HP:0002756)1.73013708
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.72962633
130Prolonged neonatal jaundice (HP:0006579)1.72692482
131Facial diplegia (HP:0001349)1.71636087
132Hyperglycinemia (HP:0002154)1.70830185
133Gangrene (HP:0100758)1.70779841
134Inflammation of the large intestine (HP:0002037)1.70747513
135Progressive inability to walk (HP:0002505)1.70088394
136Recurrent fungal infections (HP:0002841)1.68736007
137Abnormality of macrophages (HP:0004311)1.67731483
138Arterial thrombosis (HP:0004420)1.67537336
139Urticaria (HP:0001025)1.67465044
140Distal lower limb muscle weakness (HP:0009053)1.67028574
141Parakeratosis (HP:0001036)1.66971997
142Restrictive lung disease (HP:0002091)1.66620524
143Ketosis (HP:0001946)1.65179695
144Panhypogammaglobulinemia (HP:0003139)1.64518050
145Spinal muscular atrophy (HP:0007269)1.64400396
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64289651
147Recurrent viral infections (HP:0004429)1.64205904
148Chronic obstructive pulmonary disease (HP:0006510)1.64064079
149Obstructive lung disease (HP:0006536)1.64064079
150Abnormality of the lumbar spine (HP:0100712)1.62293112
151Myositis (HP:0100614)1.61992408
152Interstitial pulmonary disease (HP:0006530)1.61133540
153Abnormality of glycosphingolipid metabolism (HP:0004343)1.60847498
154Abnormality of glycolipid metabolism (HP:0010969)1.60847498
155Abnormality of liposaccharide metabolism (HP:0010968)1.60847498
156Hypoglycemic coma (HP:0001325)1.58933364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.89967363
2MUSK3.48572068
3TYK23.33248759
4MAP3K143.30733674
5RIPK42.76542880
6TGFBR22.72653361
7NME22.67884373
8DDR22.48575907
9IKBKB2.46937482
10BTK2.28429340
11TAOK32.25719577
12FGR2.20793709
13IRAK42.19630142
14CAMK1D2.12193902
15JAK12.08346078
16EPHB12.05764061
17YES11.95013278
18TAOK21.93402846
19PRPF4B1.89950124
20CSK1.87151307
21CSF1R1.81146547
22MAP3K111.80255985
23TBK11.72065388
24GRK71.71959126
25TAOK11.71842833
26ACVR1B1.68058501
27ERN11.55872832
28CDC42BPA1.50685033
29TEC1.48264517
30HCK1.43013796
31IKBKE1.41962893
32JAK21.40699135
33FGFR41.40570449
34TTN1.34915857
35RIPK11.34316319
36ZAP701.34199777
37SCYL21.32876072
38IRAK31.31641251
39LYN1.29276614
40KIT1.25089821
41NEK91.23048012
42EPHA31.22980139
43CAMK1G1.20119472
44BCKDK1.17279054
45FES1.15631451
46MAPK151.15503755
47SIK11.13539817
48MAP4K11.13197013
49PIK3CG1.06106583
50CDK61.05366080
51MAP3K11.05183427
52PTK61.00002055
53PIM20.99215471
54LCK0.94971945
55CLK10.94052731
56PDGFRB0.93554399
57MAP2K30.93415726
58TRIB30.92126636
59FGFR30.91980077
60SYK0.90609580
61CHUK0.86679372
62ITK0.86473326
63MAP2K20.85407482
64IRAK20.82685573
65TGFBR10.82533545
66DAPK20.79027150
67MARK30.77088151
68TRPM70.75592351
69MAP3K50.75560868
70PRKAA20.74969576
71EIF2AK20.72760748
72MAPK120.70675176
73TNK20.70574447
74ADRBK20.69736206
75CAMKK10.69080075
76ABL20.69036815
77FLT30.67914926
78STK100.66899254
79INSRR0.63367322
80TESK20.62823903
81MAP2K60.62242475
82GSK3A0.61575502
83PDK20.60297365
84PDPK10.60291782
85MAPK40.59544506
86PKN20.59530603
87CAMKK20.59331901
88JAK30.59315774
89FRK0.59111472
90MATK0.58641120
91MST40.58306063
92TYRO30.55809624
93PKN10.54895305
94NUAK10.52823690
95EGFR0.51324779
96RPS6KL10.51230432
97RPS6KC10.51230432
98MAP3K30.51204318
99DMPK0.51056052
100PDGFRA0.51039992
101MOS0.50922210
102SIK30.49995388
103PDK10.49702726
104TXK0.49358093
105MAPKAPK20.49272933
106TESK10.49118413
107SGK10.47817897
108MAPK70.47552307
109IGF1R0.47002792
110ROCK10.45027600
111EPHB20.42451657
112RPS6KA60.41677767
113RPS6KA20.41463649
114PRKCD0.41183405
115BMPR20.40955286
116ARAF0.40631343
117MAPK110.39387760
118PAK40.39150214
119MARK20.38669591
120FYN0.38249330
121PAK20.37253459
122MST1R0.36173513
123ABL10.35676636
124HIPK20.34785993
125MAP3K60.31080891
126MAP3K130.30354585
127PIM10.28249476
128PRKACG0.27765029
129INSR0.27568476
130MAPK30.26244202
131PRKACB0.26222595
132SRC0.26023304
133PRKG10.25633567
134KSR20.25177904
135SGK30.24816878
136PRKG20.24595840
137IRAK10.23947798

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051506.40668087
2Complement and coagulation cascades_Homo sapiens_hsa046104.09359167
3Nitrogen metabolism_Homo sapiens_hsa009103.11328057
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.02075826
5Rheumatoid arthritis_Homo sapiens_hsa053232.75044504
6Asthma_Homo sapiens_hsa053102.60540097
7Allograft rejection_Homo sapiens_hsa053302.43022904
8PPAR signaling pathway_Homo sapiens_hsa033202.32274871
9Graft-versus-host disease_Homo sapiens_hsa053322.18505142
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05798587
11Autoimmune thyroid disease_Homo sapiens_hsa053202.04956732
12Pertussis_Homo sapiens_hsa051332.03028478
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00894179
14Caffeine metabolism_Homo sapiens_hsa002321.95392708
15Fatty acid degradation_Homo sapiens_hsa000711.88043739
16Arginine biosynthesis_Homo sapiens_hsa002201.87025924
17ABC transporters_Homo sapiens_hsa020101.83266036
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77904197
19Type I diabetes mellitus_Homo sapiens_hsa049401.67488742
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66229404
21Tryptophan metabolism_Homo sapiens_hsa003801.65241528
22Osteoclast differentiation_Homo sapiens_hsa043801.63187837
23Leishmaniasis_Homo sapiens_hsa051401.60406955
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58915301
25B cell receptor signaling pathway_Homo sapiens_hsa046621.58525160
26beta-Alanine metabolism_Homo sapiens_hsa004101.52001112
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46208518
28Propanoate metabolism_Homo sapiens_hsa006401.45908730
29Fatty acid metabolism_Homo sapiens_hsa012121.44767829
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43660600
31Prion diseases_Homo sapiens_hsa050201.42656634
32Lysosome_Homo sapiens_hsa041421.38400830
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37443917
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.36728007
35Peroxisome_Homo sapiens_hsa041461.32924951
36Retinol metabolism_Homo sapiens_hsa008301.32477590
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.28054882
38Tuberculosis_Homo sapiens_hsa051521.25884558
39Viral myocarditis_Homo sapiens_hsa054161.23582131
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21515171
41Collecting duct acid secretion_Homo sapiens_hsa049661.18719386
42Histidine metabolism_Homo sapiens_hsa003401.17156025
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16516352
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14386754
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10979151
46Starch and sucrose metabolism_Homo sapiens_hsa005001.10687314
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.09692334
48Vitamin digestion and absorption_Homo sapiens_hsa049771.09081430
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08788242
50Mineral absorption_Homo sapiens_hsa049781.08199644
51Legionellosis_Homo sapiens_hsa051341.05377839
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03254895
53African trypanosomiasis_Homo sapiens_hsa051431.02861229
54Fat digestion and absorption_Homo sapiens_hsa049751.01456923
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99181016
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.98161918
57Insulin resistance_Homo sapiens_hsa049310.96215916
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90605397
59Chemical carcinogenesis_Homo sapiens_hsa052040.90444038
60Toxoplasmosis_Homo sapiens_hsa051450.89502547
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87412540
62Chemokine signaling pathway_Homo sapiens_hsa040620.85980229
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85201292
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85033549
65Malaria_Homo sapiens_hsa051440.84784387
66Sphingolipid metabolism_Homo sapiens_hsa006000.83657823
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82790677
68Phagosome_Homo sapiens_hsa041450.81823542
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81216847
70Other glycan degradation_Homo sapiens_hsa005110.80826062
71Fatty acid biosynthesis_Homo sapiens_hsa000610.78065414
72Phenylalanine metabolism_Homo sapiens_hsa003600.76197166
73Shigellosis_Homo sapiens_hsa051310.74460166
74Measles_Homo sapiens_hsa051620.72638466
75Butanoate metabolism_Homo sapiens_hsa006500.72605026
76Bladder cancer_Homo sapiens_hsa052190.71575182
77Hepatitis B_Homo sapiens_hsa051610.69067248
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67245653
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.66146477
80Apoptosis_Homo sapiens_hsa042100.65206049
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63775220
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63693891
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63649019
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.63429251
85Influenza A_Homo sapiens_hsa051640.62943677
86Salmonella infection_Homo sapiens_hsa051320.61554315
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.60534887
88Fatty acid elongation_Homo sapiens_hsa000620.60463136
89Bile secretion_Homo sapiens_hsa049760.59375896
90Platelet activation_Homo sapiens_hsa046110.59212001
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58035516
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57349517
93Vibrio cholerae infection_Homo sapiens_hsa051100.56703243
94Amoebiasis_Homo sapiens_hsa051460.56262133
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54968253
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54194822
97Antigen processing and presentation_Homo sapiens_hsa046120.53123948
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.52805477
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52265904
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52104676
101Glycerolipid metabolism_Homo sapiens_hsa005610.49947426
102Acute myeloid leukemia_Homo sapiens_hsa052210.49822506
103Primary immunodeficiency_Homo sapiens_hsa053400.49707825
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49396393
105Hepatitis C_Homo sapiens_hsa051600.48724205
106Arachidonic acid metabolism_Homo sapiens_hsa005900.48711500
107Type II diabetes mellitus_Homo sapiens_hsa049300.47849585
108Hematopoietic cell lineage_Homo sapiens_hsa046400.47056307
109Tyrosine metabolism_Homo sapiens_hsa003500.46733080
110Prolactin signaling pathway_Homo sapiens_hsa049170.46443240
111Galactose metabolism_Homo sapiens_hsa000520.45269411
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.44116379
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42358197
114VEGF signaling pathway_Homo sapiens_hsa043700.42010548
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39974444
116Lysine degradation_Homo sapiens_hsa003100.39956061
117One carbon pool by folate_Homo sapiens_hsa006700.38539205
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38137211
119HIF-1 signaling pathway_Homo sapiens_hsa040660.36270769
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36203914
121Epstein-Barr virus infection_Homo sapiens_hsa051690.36120670
122Endocytosis_Homo sapiens_hsa041440.35048451
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.34961706
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34637670
125Systemic lupus erythematosus_Homo sapiens_hsa053220.34362032
126Carbon metabolism_Homo sapiens_hsa012000.33485788
127Pyruvate metabolism_Homo sapiens_hsa006200.32597058
128T cell receptor signaling pathway_Homo sapiens_hsa046600.32515520
129TNF signaling pathway_Homo sapiens_hsa046680.31849859
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29670597
131Sulfur metabolism_Homo sapiens_hsa009200.28604434
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28432515
133Renin-angiotensin system_Homo sapiens_hsa046140.27995101
134Steroid biosynthesis_Homo sapiens_hsa001000.27940403
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27769866
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.27041109
137Pentose phosphate pathway_Homo sapiens_hsa000300.26957434
138Herpes simplex infection_Homo sapiens_hsa051680.25485259
139GnRH signaling pathway_Homo sapiens_hsa049120.25189759
140Arginine and proline metabolism_Homo sapiens_hsa003300.25140370
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22435193
142Synaptic vesicle cycle_Homo sapiens_hsa047210.22070931
143HTLV-I infection_Homo sapiens_hsa051660.21361237
144Renal cell carcinoma_Homo sapiens_hsa052110.20514580
145Notch signaling pathway_Homo sapiens_hsa043300.20464041
146Dorso-ventral axis formation_Homo sapiens_hsa043200.19832272
147Pancreatic cancer_Homo sapiens_hsa052120.18151804
148Chronic myeloid leukemia_Homo sapiens_hsa052200.15437844
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12529156
150Fructose and mannose metabolism_Homo sapiens_hsa000510.11770533

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