CD160

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)9.70028462
2regulation of gene silencing by miRNA (GO:0060964)9.70028462
3regulation of gene silencing by RNA (GO:0060966)9.70028462
4fatty acid elongation (GO:0030497)9.15030862
5negative regulation of gene silencing (GO:0060969)7.67752173
6negative T cell selection (GO:0043383)7.01629361
7negative thymic T cell selection (GO:0045060)6.86690831
8cellular response to interleukin-15 (GO:0071350)6.76887247
9microglial cell activation (GO:0001774)6.66603920
10regulation of isotype switching to IgG isotypes (GO:0048302)6.57767648
11interferon-gamma production (GO:0032609)6.44613746
12positive regulation of gamma-delta T cell activation (GO:0046645)6.40174082
13positive thymic T cell selection (GO:0045059)6.31181999
14macrophage activation involved in immune response (GO:0002281)6.11529282
15membrane tubulation (GO:0097320)6.04594933
16behavioral response to nicotine (GO:0035095)5.93507609
17response to interleukin-15 (GO:0070672)5.88629166
18thymic T cell selection (GO:0045061)5.87101101
19intra-S DNA damage checkpoint (GO:0031573)5.80132645
20positive T cell selection (GO:0043368)5.55204486
21regulation of DNA damage checkpoint (GO:2000001)5.53161856
22regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.47330087
23negative regulation of cell killing (GO:0031342)5.44932065
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.44932065
25myoblast migration (GO:0051451)5.34367527
26regulation of natural killer cell mediated immunity (GO:0002715)5.25426787
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.25426787
28regulation of gamma-delta T cell differentiation (GO:0045586)5.23145715
29positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.19798912
30positive regulation of natural killer cell mediated immunity (GO:0002717)5.19798912
31regulation of T cell tolerance induction (GO:0002664)5.19212202
32response to pheromone (GO:0019236)5.18950141
33leukocyte aggregation (GO:0070486)5.18576327
34regulation of B cell receptor signaling pathway (GO:0050855)5.14172765
35T cell migration (GO:0072678)5.07912858
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.01913620
37skeletal muscle tissue regeneration (GO:0043403)4.98683019
38T cell costimulation (GO:0031295)4.98132247
39autophagic vacuole fusion (GO:0000046)4.95823890
40T cell selection (GO:0045058)4.93162841
41macrophage chemotaxis (GO:0048246)4.91594076
42lymphocyte costimulation (GO:0031294)4.89867061
43phagocytosis, engulfment (GO:0006911)4.81435583
44regulation of gamma-delta T cell activation (GO:0046643)4.78347039
45T cell receptor signaling pathway (GO:0050852)4.72748363
46activated T cell proliferation (GO:0050798)4.72679155
47positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.64083412
48positive regulation of alpha-beta T cell proliferation (GO:0046641)4.58257444
49positive regulation of B cell mediated immunity (GO:0002714)4.50555860
50positive regulation of immunoglobulin mediated immune response (GO:0002891)4.50555860
51heart trabecula morphogenesis (GO:0061384)4.48044709
52positive regulation of humoral immune response (GO:0002922)4.47780150
53positive regulation of isotype switching (GO:0045830)4.45639241
54positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.42920925
55regulation of alpha-beta T cell proliferation (GO:0046640)4.41650212
56inner cell mass cell proliferation (GO:0001833)4.35958567
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29051431
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29051431
59regulation of leukocyte mediated cytotoxicity (GO:0001910)4.28788535
60positive regulation of cell killing (GO:0031343)4.20943163
61positive regulation of immune response to tumor cell (GO:0002839)4.18815784
62regulation of immune response to tumor cell (GO:0002837)4.18815784
63regulation of response to tumor cell (GO:0002834)4.18815784
64positive regulation of response to tumor cell (GO:0002836)4.18815784
65regulation of immunoglobulin mediated immune response (GO:0002889)4.17355200
66cellular response to gamma radiation (GO:0071480)4.15634540
67organelle membrane fusion (GO:0090174)4.14340851
68regulation of T cell receptor signaling pathway (GO:0050856)4.13243706
69chemokine-mediated signaling pathway (GO:0070098)4.11900740
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.11541167
71positive regulation of tolerance induction (GO:0002645)4.09639335
72regulation of cell killing (GO:0031341)4.05418779
73regulation of interferon-gamma-mediated signaling pathway (GO:0060334)4.03993615
74regulation of B cell mediated immunity (GO:0002712)4.03392965
75antigen receptor-mediated signaling pathway (GO:0050851)4.01674115
76regulation of response to interferon-gamma (GO:0060330)3.99348685
77positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.96507780
78positive regulation of cell cycle G2/M phase transition (GO:1902751)3.96507780
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.93711550
80positive regulation of DNA recombination (GO:0045911)3.91682302
81regulation of interleukin-12 biosynthetic process (GO:0045075)3.82493620
82regulation of isotype switching (GO:0045191)3.77619848
83negative regulation of T cell receptor signaling pathway (GO:0050860)3.77039518
84negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.75766031
85positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.75593066
86regulation of regulatory T cell differentiation (GO:0045589)3.72315435
87myeloid cell activation involved in immune response (GO:0002275)3.69716999
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.69447184
89protein import into peroxisome matrix (GO:0016558)3.67041228
90regulation of histone H3-K27 methylation (GO:0061085)3.62188616
91negative regulation of striated muscle cell apoptotic process (GO:0010664)3.58107646
92regulation of tolerance induction (GO:0002643)3.55956071
93positive regulation of lymphocyte mediated immunity (GO:0002708)3.53832598
94antigen processing and presentation of endogenous antigen (GO:0019883)3.53458423
95nucleoside diphosphate catabolic process (GO:0009134)3.51927589
96sequestering of actin monomers (GO:0042989)3.51397042
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.44822699
98positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.41809162
99lymphocyte migration (GO:0072676)3.41380899
100long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.40110041
101negative regulation of lymphocyte mediated immunity (GO:0002707)3.39298152
102regulation of lymphocyte mediated immunity (GO:0002706)3.38758460
103NIK/NF-kappaB signaling (GO:0038061)3.35055369
104trabecula morphogenesis (GO:0061383)3.32064812
105macrophage activation (GO:0042116)3.31756380
106DNA deamination (GO:0045006)3.30311904
107* cellular defense response (GO:0006968)3.28013957
108negative regulation of T cell mediated immunity (GO:0002710)3.27655568
109positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26843980
110T cell differentiation (GO:0030217)3.25784326
111regulation of T cell mediated cytotoxicity (GO:0001914)3.23199119
112positive regulation of immunoglobulin production (GO:0002639)3.22142355
113mast cell activation (GO:0045576)3.22074253
114negative regulation of interleukin-12 production (GO:0032695)3.21445649
115regulation of gene silencing (GO:0060968)3.21310684
116T cell activation (GO:0042110)3.19915088
117positive regulation of skeletal muscle tissue development (GO:0048643)3.18481930
118regulation of interleukin-2 biosynthetic process (GO:0045076)3.18011112
119RNA methylation (GO:0001510)3.16961853
120hepatocyte apoptotic process (GO:0097284)3.15827773
121regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.15135556
122negative regulation of neurotransmitter secretion (GO:0046929)3.13877623
123natural killer cell activation (GO:0030101)3.13740439
124regulation of type I interferon-mediated signaling pathway (GO:0060338)3.12515189
125cellular extravasation (GO:0045123)3.11763668
126mast cell activation involved in immune response (GO:0002279)3.11212327
127mast cell degranulation (GO:0043303)3.11212327
128regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.09387746
129regulation of immunoglobulin production (GO:0002637)3.08809316
130positive regulation of defense response to virus by host (GO:0002230)3.07741429
131regulation of T cell chemotaxis (GO:0010819)3.07453580
132positive regulation of T cell chemotaxis (GO:0010820)3.07453580
133mitochondrial calcium ion transport (GO:0006851)3.07296305
134Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05330157
135fatty-acyl-CoA biosynthetic process (GO:0046949)3.02301827
136positive regulation of T cell activation (GO:0050870)3.00716045
137positive regulation of T-helper 1 type immune response (GO:0002827)2.99565920
138positive regulation of leukocyte mediated immunity (GO:0002705)2.99346219
139leukocyte cell-cell adhesion (GO:0007159)2.98919122
140positive regulation of interleukin-4 production (GO:0032753)2.98891707
141regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.98868707
142alpha-beta T cell differentiation involved in immune response (GO:0002293)2.92401674
143alpha-beta T cell activation involved in immune response (GO:0002287)2.92401674
144T cell differentiation involved in immune response (GO:0002292)2.92401674
145DNA damage response, detection of DNA damage (GO:0042769)2.91924737
146positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.90055261
147regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.88565773
148T cell homeostasis (GO:0043029)2.88505733
149positive regulation of interferon-gamma production (GO:0032729)2.87726406
150regulation of memory T cell differentiation (GO:0043380)2.82471459
151regulation of cell cycle checkpoint (GO:1901976)2.82018084
152response to nitrosative stress (GO:0051409)2.78962122
153negative regulation of neurotransmitter transport (GO:0051589)2.75902866
154regulation of lymphocyte chemotaxis (GO:1901623)2.74237207
155negative regulation of telomere maintenance (GO:0032205)2.71488323
156lymph node development (GO:0048535)2.70814642
157long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.68986838
158membrane invagination (GO:0010324)2.68733274
159regulation of mitotic spindle checkpoint (GO:1903504)2.68208055
160regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68208055
161cytidine metabolic process (GO:0046087)2.66256521
162cytidine catabolic process (GO:0006216)2.66256521
163cytidine deamination (GO:0009972)2.66256521
164neutrophil activation involved in immune response (GO:0002283)2.64118871
165regulation of striated muscle cell apoptotic process (GO:0010662)2.61468977
166response to xenobiotic stimulus (GO:0009410)2.61302474
167regulation of B cell differentiation (GO:0045577)2.60654995
168renal tubule morphogenesis (GO:0061333)2.59292219
169thioester biosynthetic process (GO:0035384)2.56869904
170histone H4-K12 acetylation (GO:0043983)11.4810970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.93360156
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.05984584
3E2F7_22180533_ChIP-Seq_HELA_Human4.25711037
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.98022953
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.92043395
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.91204662
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.86883465
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.82971905
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.54086404
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.45296130
11MYB_26560356_Chip-Seq_TH2_Human3.43129866
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.36069621
13RUNX_20019798_ChIP-Seq_JUKART_Human3.33312373
14MYC_22102868_ChIP-Seq_BL_Human3.07156349
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85567983
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.81992708
17MYB_26560356_Chip-Seq_TH1_Human2.80206317
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.72819320
19MAF_26560356_Chip-Seq_TH1_Human2.71721500
20UTX_26944678_Chip-Seq_JUKART_Human2.71321168
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.66392135
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63597384
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43989188
24GATA3_27048872_Chip-Seq_THYMUS_Human2.18640217
25VDR_22108803_ChIP-Seq_LS180_Human2.16640366
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12174681
27ZNF274_21170338_ChIP-Seq_K562_Hela2.05405732
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05356690
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03418499
30MAF_26560356_Chip-Seq_TH2_Human2.01239683
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96977591
32TAF15_26573619_Chip-Seq_HEK293_Human1.88604997
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85591423
34SPI1_23547873_ChIP-Seq_NB4_Human1.82982041
35GBX2_23144817_ChIP-Seq_PC3_Human1.81979582
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81734627
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.80875983
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78464586
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75211074
40ER_23166858_ChIP-Seq_MCF-7_Human1.73109085
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71215273
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68548815
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62537158
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62058023
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62002085
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61700093
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61438867
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59262426
49VDR_21846776_ChIP-Seq_THP-1_Human1.55692815
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54183501
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.53892247
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53328509
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51682981
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51676969
55VDR_23849224_ChIP-Seq_CD4+_Human1.45815152
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42019241
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.41858539
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41524524
59TCF7_22412390_ChIP-Seq_EML_Mouse1.37113062
60AR_20517297_ChIP-Seq_VCAP_Human1.35624724
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34981226
62HTT_18923047_ChIP-ChIP_STHdh_Human1.34671588
63CBP_20019798_ChIP-Seq_JUKART_Human1.32976728
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32976728
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32398051
66* GATA3_26560356_Chip-Seq_TH2_Human1.32395625
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31712409
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30005641
69IGF1R_20145208_ChIP-Seq_DFB_Human1.27889112
70VDR_24763502_ChIP-Seq_THP-1_Human1.27739483
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27211368
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27047397
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.23854087
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22518540
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.21822810
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21134939
77FOXP3_21729870_ChIP-Seq_TREG_Human1.20427562
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18647896
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18471210
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17999648
81P300_19829295_ChIP-Seq_ESCs_Human1.17922570
82TCF4_23295773_ChIP-Seq_U87_Human1.17174941
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17057061
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.16448283
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15436082
86SPI1_23127762_ChIP-Seq_K562_Human1.15130515
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.14804490
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14804490
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.14692910
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14137917
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13757459
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12405000
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12261740
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.12084752
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11479427
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11327513
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10894349
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10685419
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.10648066
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.09901191
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.09415098
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09122089
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08435874
104PU_27001747_Chip-Seq_BMDM_Mouse1.07934355
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07236704
106BCAT_22108803_ChIP-Seq_LS180_Human1.06696824
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06036645
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05647789
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05477334
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04648719
111EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04291928
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.03960210
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03773896
114STAT3_23295773_ChIP-Seq_U87_Human1.03279532
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99865971
116FUS_26573619_Chip-Seq_HEK293_Human0.99650232
117RUNX2_22187159_ChIP-Seq_PCA_Human0.99611500
118* SMAD4_21799915_ChIP-Seq_A2780_Human0.99074790
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98512001
120TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97509262
121ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97460797
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97447860
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96710242
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96582510
125TP53_22573176_ChIP-Seq_HFKS_Human0.95110549
126KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95102717
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.94839030
128KDM2B_26808549_Chip-Seq_DND41_Human0.94631366
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94454936
130FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93779569
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93644164
132ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93088464
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93013490
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92746761
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92243102
136STAT1_20625510_ChIP-Seq_HELA_Human0.92235985
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92089677
138PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91876129
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91795050
140REST_21632747_ChIP-Seq_MESCs_Mouse0.91307900
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89070024
142* MYC_18940864_ChIP-ChIP_HL60_Human0.88898926
143SCL_19346495_ChIP-Seq_HPC-7_Human0.87343584
144E2F1_21310950_ChIP-Seq_MCF-7_Human0.83114240
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82172050
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81702176
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.81431031
148VDR_24787735_ChIP-Seq_THP-1_Human0.81170829
149CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80775758
150FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79276703
151SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78916808
152CIITA_25753668_ChIP-Seq_RAJI_Human0.78815206
153RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76647077
154NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76398145
155EST1_17652178_ChIP-ChIP_JURKAT_Human0.75692973
156DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73149141
157RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70952578
158LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69708621
159TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69519153
160FLI1_21867929_ChIP-Seq_CD8_Mouse0.68951205
161LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.68905855
162EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.67977758
163AR_21909140_ChIP-Seq_LNCAP_Human0.66481403
164KDM2B_26808549_Chip-Seq_SUP-B15_Human0.66119996
165VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.64169832
166CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64153012
167SMRT_27268052_Chip-Seq_Bcells_Human0.62662854
168TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.62657782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.73812632
2MP0003763_abnormal_thymus_physiology5.41928679
3MP0008260_abnormal_autophagy3.46657915
4MP0001835_abnormal_antigen_presentation3.36587091
5MP0000685_abnormal_immune_system3.28875877
6MP0001800_abnormal_humoral_immune3.16175703
7MP0009785_altered_susceptibility_to3.14170453
8MP0001188_hyperpigmentation2.93561896
9MP0006082_CNS_inflammation2.91078469
10MP0009333_abnormal_splenocyte_physiolog2.89960622
11MP0005000_abnormal_immune_tolerance2.85569234
12MP0002420_abnormal_adaptive_immunity2.80894718
13MP0002398_abnormal_bone_marrow2.77469284
14MP0001819_abnormal_immune_cell2.76409824
15MP0002723_abnormal_immune_serum2.76096389
16MP0002166_altered_tumor_susceptibility2.74591774
17MP0002405_respiratory_system_inflammati2.73827725
18MP0002006_tumorigenesis2.68248718
19MP0005387_immune_system_phenotype2.62534291
20MP0001790_abnormal_immune_system2.62534291
21MP0000703_abnormal_thymus_morphology2.56756548
22MP0003567_abnormal_fetal_cardiomyocyte2.55674578
23MP0003724_increased_susceptibility_to2.50993310
24MP0002452_abnormal_antigen_presenting2.43364361
25MP0001873_stomach_inflammation2.38527434
26MP0000716_abnormal_immune_system2.38485757
27MP0004883_abnormal_blood_vessel2.38105684
28MP0005025_abnormal_response_to2.36434819
29MP0002722_abnormal_immune_system2.24389336
30MP0003690_abnormal_glial_cell2.22933196
31MP0002933_joint_inflammation2.16977514
32MP0000689_abnormal_spleen_morphology2.11339164
33MP0004510_myositis2.07145433
34MP0004185_abnormal_adipocyte_glucose1.99241291
35MP0004947_skin_inflammation1.93777109
36MP0003436_decreased_susceptibility_to1.93125695
37MP0002429_abnormal_blood_cell1.93120083
38MP0002638_abnormal_pupillary_reflex1.92141430
39MP0010155_abnormal_intestine_physiology1.86996245
40MP0005451_abnormal_body_composition1.86281085
41MP0002396_abnormal_hematopoietic_system1.77751761
42MP0005310_abnormal_salivary_gland1.74764857
43MP0002876_abnormal_thyroid_physiology1.73935820
44MP0003866_abnormal_defecation1.71106409
45MP0000858_altered_metastatic_potential1.69613251
46MP0003693_abnormal_embryo_hatching1.68256530
47MP0002419_abnormal_innate_immunity1.65894054
48MP0003300_gastrointestinal_ulcer1.65377007
49MP0003195_calcinosis1.64245614
50MP0003718_maternal_effect1.63071543
51MP0003183_abnormal_peptide_metabolism1.61746235
52MP0001845_abnormal_inflammatory_respons1.58496876
53MP0003448_altered_tumor_morphology1.57495038
54MP0010094_abnormal_chromosome_stability1.56013322
55MP0001986_abnormal_taste_sensitivity1.53105874
56MP0004381_abnormal_hair_follicle1.51320750
57MP0004043_abnormal_pH_regulation1.49522603
58MP0006072_abnormal_retinal_apoptosis1.48642194
59MP0005551_abnormal_eye_electrophysiolog1.48063115
60MP0004142_abnormal_muscle_tone1.45437254
61MP0004957_abnormal_blastocyst_morpholog1.44297178
62MP0002019_abnormal_tumor_incidence1.41973298
63MP0004885_abnormal_endolymph1.41194853
64MP0004019_abnormal_vitamin_homeostasis1.40596078
65MP0003077_abnormal_cell_cycle1.39843523
66MP0000750_abnormal_muscle_regeneration1.39765302
67MP0002837_dystrophic_cardiac_calcinosis1.39200100
68MP0005166_decreased_susceptibility_to1.39188115
69MP0002148_abnormal_hypersensitivity_rea1.35167279
70MP0005464_abnormal_platelet_physiology1.31830944
71MP0001915_intracranial_hemorrhage1.31197931
72MP0001851_eye_inflammation1.30271623
73MP0000465_gastrointestinal_hemorrhage1.23940562
74MP0005164_abnormal_response_to1.20755123
75MP0002009_preneoplasia1.18136072
76MP0000490_abnormal_crypts_of1.18043661
77MP0002254_reproductive_system_inflammat1.17053652
78MP0001119_abnormal_female_reproductive1.16222301
79MP0000427_abnormal_hair_cycle1.15417308
80MP0005083_abnormal_biliary_tract1.09472285
81MP0008872_abnormal_physiological_respon1.08733695
82MP0001243_abnormal_dermal_layer1.08687624
83MP0008877_abnormal_DNA_methylation1.07749134
84MP0005075_abnormal_melanosome_morpholog1.04776839
85MP0009745_abnormal_behavioral_response1.04311288
86MP0003111_abnormal_nucleus_morphology1.04254179
87MP0001853_heart_inflammation1.04214920
88MP0006054_spinal_hemorrhage1.04072527
89MP0008057_abnormal_DNA_replication1.02529184
90MP0001501_abnormal_sleep_pattern1.01749666
91MP0002102_abnormal_ear_morphology0.98202306
92MP0005408_hypopigmentation0.97796132
93MP0005645_abnormal_hypothalamus_physiol0.97705630
94MP0003252_abnormal_bile_duct0.95654009
95MP0001968_abnormal_touch/_nociception0.93732223
96MP0001533_abnormal_skeleton_physiology0.93588593
97MP0004130_abnormal_muscle_cell0.92640914
98MP0008875_abnormal_xenobiotic_pharmacok0.92570615
99MP0008007_abnormal_cellular_replicative0.91190625
100MP0002132_abnormal_respiratory_system0.90722854
101MP0004808_abnormal_hematopoietic_stem0.90146062
102MP0008873_increased_physiological_sensi0.89903628
103MP0008469_abnormal_protein_level0.89329039
104MP0002998_abnormal_bone_remodeling0.88375599
105MP0005448_abnormal_energy_balance0.87145981
106MP0009763_increased_sensitivity_to0.86905500
107MP0000372_irregular_coat_pigmentation0.81471678
108MP0001348_abnormal_lacrimal_gland0.79489455
109MP0003699_abnormal_female_reproductive0.79300575
110MP0010307_abnormal_tumor_latency0.78603556
111MP0005646_abnormal_pituitary_gland0.78074740
112MP0005395_other_phenotype0.78032391
113MP0000631_abnormal_neuroendocrine_gland0.77491620
114MP0003787_abnormal_imprinting0.74495978
115MP0005376_homeostasis/metabolism_phenot0.74137432
116MP0005389_reproductive_system_phenotype0.74034963
117MP0002693_abnormal_pancreas_physiology0.72580633
118MP0003453_abnormal_keratinocyte_physiol0.72153617
119MP0000604_amyloidosis0.71566501
120MP0010386_abnormal_urinary_bladder0.69070381
121MP0000230_abnormal_systemic_arterial0.69005574
122MP0002095_abnormal_skin_pigmentation0.68226482
123MP0008058_abnormal_DNA_repair0.67916334
124MP0005023_abnormal_wound_healing0.67776824
125MP0005253_abnormal_eye_physiology0.66006042
126MP0001881_abnormal_mammary_gland0.65489384
127MP0009765_abnormal_xenobiotic_induced0.65422567
128MP0005670_abnormal_white_adipose0.64040456
129MP0000920_abnormal_myelination0.62988910
130MP0001765_abnormal_ion_homeostasis0.62739101
131MP0005595_abnormal_vascular_smooth0.62412517
132MP0002735_abnormal_chemical_nociception0.62397518
133MP0002736_abnormal_nociception_after0.62260802
134MP0000613_abnormal_salivary_gland0.58805884
135MP0008932_abnormal_embryonic_tissue0.57674090
136MP0001929_abnormal_gametogenesis0.57257869
137MP0000015_abnormal_ear_pigmentation0.55650734
138MP0010234_abnormal_vibrissa_follicle0.55122595
139MP0001919_abnormal_reproductive_system0.54309809
140MP0009764_decreased_sensitivity_to0.52217165
141MP0002138_abnormal_hepatobiliary_system0.52141156
142MP0000350_abnormal_cell_proliferation0.51770351
143MP0000313_abnormal_cell_death0.51631270
144MP0003045_fibrosis0.50750922
145MP0000477_abnormal_intestine_morphology0.50660341
146MP0005174_abnormal_tail_pigmentation0.48177373
147MP0002136_abnormal_kidney_physiology0.47960403
148MP0003943_abnormal_hepatobiliary_system0.47231744
149MP0000653_abnormal_sex_gland0.46571994
150MP0003646_muscle_fatigue0.46253187
151MP0000627_abnormal_mammary_gland0.42060365
152MP0004782_abnormal_surfactant_physiolog0.41261678
153MP0000569_abnormal_digit_pigmentation0.41167151

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.22658988
2Severe combined immunodeficiency (HP:0004430)7.11447609
3Abnormality of T cell number (HP:0011839)7.00823914
4Combined immunodeficiency (HP:0005387)6.85201008
5Abnormality of T cells (HP:0002843)5.09929830
6Congenital stationary night blindness (HP:0007642)4.97541655
7Scotoma (HP:0000575)4.90654499
8Elevated erythrocyte sedimentation rate (HP:0003565)4.86541933
9Hyperlipoproteinemia (HP:0010980)4.86157248
10IgG deficiency (HP:0004315)4.85057409
11Deep palmar crease (HP:0006191)4.78873665
12Myositis (HP:0100614)4.77514554
13Severe visual impairment (HP:0001141)4.58687712
14Chronic mucocutaneous candidiasis (HP:0002728)4.56417430
15Recurrent cutaneous fungal infections (HP:0011370)4.56417430
16Thyroiditis (HP:0100646)4.51975010
17Recurrent bronchitis (HP:0002837)4.50765486
18Recurrent fungal infections (HP:0002841)4.49636490
19Stomatitis (HP:0010280)4.48115531
20Optic neuritis (HP:0100653)4.32465048
21Retrobulbar optic neuritis (HP:0100654)4.32465048
22Increased IgM level (HP:0003496)4.16805272
23Eczematoid dermatitis (HP:0000976)4.10480613
24Chronic diarrhea (HP:0002028)4.08795635
25Autoimmune hemolytic anemia (HP:0001890)4.06670607
26Abnormality of eosinophils (HP:0001879)4.01265970
27Epidermoid cyst (HP:0200040)3.92623442
28Nasal polyposis (HP:0100582)3.91832428
29IgM deficiency (HP:0002850)3.91365137
30Cortical dysplasia (HP:0002539)3.89135169
31Panhypogammaglobulinemia (HP:0003139)3.87916977
32Gastrointestinal infarctions (HP:0005244)3.87355052
33Orchitis (HP:0100796)3.83600342
34Lymphopenia (HP:0001888)3.68520730
35Central scotoma (HP:0000603)3.67032141
36Submucous cleft hard palate (HP:0000176)3.66976432
37Alveolar cell carcinoma (HP:0006519)3.64978162
38Leukocytosis (HP:0001974)3.61714075
39Abnormality of cells of the lymphoid lineage (HP:0012140)3.58157005
40Recurrent viral infections (HP:0004429)3.55684482
41Abnormality of the fingertips (HP:0001211)3.53411237
42Decreased electroretinogram (ERG) amplitude (HP:0000654)3.47489529
43Hypoplasia of the thymus (HP:0000778)3.44202041
44Joint swelling (HP:0001386)3.39177931
45Neoplasm of the tracheobronchial system (HP:0100552)3.36752600
46Abnormal delayed hypersensitivity skin test (HP:0002963)3.35784763
47Curly hair (HP:0002212)3.32834871
48Abnormal rod and cone electroretinograms (HP:0008323)3.25080764
49Pulmonary infiltrates (HP:0002113)3.20814065
50Abnormality of T cell physiology (HP:0011840)3.19068524
51Renal cortical cysts (HP:0000803)3.11428880
52Meningitis (HP:0001287)3.05708475
53Progressive microcephaly (HP:0000253)3.04751026
54Asplenia (HP:0001746)3.03249149
55Hemoptysis (HP:0002105)3.02973199
56Encephalitis (HP:0002383)3.02634603
57Abnormality of the nasal mucosa (HP:0000433)3.02425029
58Stomach cancer (HP:0012126)2.97692835
59Recurrent abscess formation (HP:0002722)2.97650335
60Chronic otitis media (HP:0000389)2.95882653
61Poor head control (HP:0002421)2.95407739
62Dyschromatopsia (HP:0007641)2.94478601
63Keratoconjunctivitis sicca (HP:0001097)2.93893965
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.92631127
65Mediastinal lymphadenopathy (HP:0100721)2.90213435
66Bronchitis (HP:0012387)2.88858010
67Recurrent skin infections (HP:0001581)2.88857514
68Pustule (HP:0200039)2.85933651
69Abnormality of the prostate (HP:0008775)2.85385032
70Abnormality of B cell number (HP:0010975)2.80917667
71B lymphocytopenia (HP:0010976)2.80917667
72Vasculitis (HP:0002633)2.80912474
73Hypoproteinemia (HP:0003075)2.77127970
74Bulbous nose (HP:0000414)2.75706194
75Arterial thrombosis (HP:0004420)2.74395224
76Pachygyria (HP:0001302)2.73562651
77Brushfield spots (HP:0001088)2.72910563
78Eosinophilia (HP:0001880)2.71980467
79Chronic obstructive pulmonary disease (HP:0006510)2.71286408
80Obstructive lung disease (HP:0006536)2.71286408
81Agammaglobulinemia (HP:0004432)2.69142178
82Pulmonary fibrosis (HP:0002206)2.66061251
83Keratoconjunctivitis (HP:0001096)2.63053592
84Lymphoma (HP:0002665)2.52957510
85Decreased circulating renin level (HP:0003351)2.51399350
86Attenuation of retinal blood vessels (HP:0007843)2.45198881
87Oligomenorrhea (HP:0000876)2.41474537
88Male infertility (HP:0003251)2.39614634
89Hypergammaglobulinemia (HP:0010702)2.39433758
90Abnormality of the renal cortex (HP:0011035)2.34680926
91Recurrent bacterial skin infections (HP:0005406)2.34578600
92Granulocytopenia (HP:0001913)2.33906161
93Type 2 muscle fiber atrophy (HP:0003554)2.32110225
94Recurrent otitis media (HP:0000403)2.31884725
95Gangrene (HP:0100758)2.28690673
96Hemiplegia (HP:0002301)2.28026513
97Short chin (HP:0000331)2.27969459
98Recurrent sinusitis (HP:0011108)2.27782708
99Xanthomatosis (HP:0000991)2.24987523
100Thickened nuchal skin fold (HP:0000474)2.22905332
101IgA deficiency (HP:0002720)2.19295230
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17641441
103Bronchiectasis (HP:0002110)2.16316685
104Large for gestational age (HP:0001520)2.13699664
105Bony spicule pigmentary retinopathy (HP:0007737)2.13554957
106Cheilitis (HP:0100825)2.13423980
107Anorexia (HP:0002039)2.09461888
108Amyotrophic lateral sclerosis (HP:0007354)2.09224423
109Hemiparesis (HP:0001269)2.08134195
110Pulmonary embolism (HP:0002204)2.07658533
111Thrombocytosis (HP:0001894)2.05923267
112Aplastic anemia (HP:0001915)2.04197856
113Hypochromic anemia (HP:0001931)2.03698693
114Birth length less than 3rd percentile (HP:0003561)2.03322525
115Autoimmune thrombocytopenia (HP:0001973)2.02004478
116Increased circulating renin level (HP:0000848)2.01847916
117Underdeveloped supraorbital ridges (HP:0009891)2.01262616
118Hypoalbuminemia (HP:0003073)2.01033560
119Abnormal albumin level (HP:0012116)2.01033560
120Spinal cord lesions (HP:0100561)1.98427319
121Syringomyelia (HP:0003396)1.98427319
122Amaurosis fugax (HP:0100576)1.98424850
123Absent eyebrow (HP:0002223)1.98262357
124Aplasia/Hypoplasia of the thymus (HP:0010515)1.98135573
125Increased density of long bones (HP:0006392)1.96291425
1263-Methylglutaconic aciduria (HP:0003535)1.95122189
127Abnormality of the endocardium (HP:0004306)1.94574395
128Increased IgE level (HP:0003212)1.94371271
129Acute myeloid leukemia (HP:0004808)1.93535002
130Chest pain (HP:0100749)1.92225092
131Premature ovarian failure (HP:0008209)1.90176149
132Prominent nose (HP:0000448)1.89176877
133Abnormality of macular pigmentation (HP:0008002)1.89071185
134Spondylolisthesis (HP:0003302)1.85945097
135Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.85866488
136Impulsivity (HP:0100710)1.84692494
137Trigonocephaly (HP:0000243)1.84671240
138Ureteral stenosis (HP:0000071)1.84027230
139Inflammation of the large intestine (HP:0002037)1.82048973
140Glucose intolerance (HP:0000833)1.81667959
141Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.80451174
142Thyroid-stimulating hormone excess (HP:0002925)1.79864873
143Abnormality of the pleura (HP:0002103)1.79605903
144Congenital, generalized hypertrichosis (HP:0004540)1.79587271
145Flared iliac wings (HP:0002869)1.79431665
146Constricted visual fields (HP:0001133)1.77583797
147Abnormality of vitamin metabolism (HP:0100508)1.76885292
148Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76801095
149Abnormal pupillary function (HP:0007686)1.75825045
150Spontaneous hematomas (HP:0007420)1.75779840
151Abnormality of small intestinal villus morphology (HP:0011472)1.75724528
152Villous atrophy (HP:0011473)1.75724528
153Keratitis (HP:0000491)1.75529869
154Hematochezia (HP:0002573)1.73000191
155Gastrointestinal inflammation (HP:0004386)1.71687232
156Progressive cerebellar ataxia (HP:0002073)1.71679612
157Genetic anticipation (HP:0003743)1.71086293
158Glomerulopathy (HP:0100820)1.68713116
159Polyneuropathy (HP:0001271)1.68243194
160Ureteral obstruction (HP:0006000)1.67750820
161Sparse lateral eyebrow (HP:0005338)1.65653629
162Muscle fiber atrophy (HP:0100295)1.63598494
163Hepatitis (HP:0012115)1.61328562
164Epistaxis (HP:0000421)1.57961327
165Premature graying of hair (HP:0002216)1.57604444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.43428232
2TXK6.96816067
3TAF15.83580394
4MAP4K15.03211497
5ZAP703.16148936
6KDR3.15513895
7PIK3CG3.03423456
8JAK33.01790174
9TESK23.01114481
10TAOK32.86699952
11MARK32.78497950
12ITK2.68795857
13IKBKE2.51537355
14FRK2.48253626
15STK102.36548288
16ILK2.32907385
17FGFR42.23632046
18JAK12.17472224
19TYK22.12526394
20KSR12.08744990
21SGK21.93820160
22LCK1.88526240
23MAP3K131.84519707
24EPHB11.81807967
25EEF2K1.67264986
26NLK1.66378799
27RIPK11.63190311
28CSK1.55626423
29TAOK11.53524554
30MAP3K141.51163312
31MAP4K21.50570327
32KIT1.45428065
33TBK11.42293321
34FGFR31.41914634
35PRKCI1.38471008
36CDC71.37078554
37GRK61.34348889
38BMPR21.32069541
39PLK41.30918196
40TEC1.30869978
41MAP3K121.28285443
42MAP3K61.28031252
43MAP2K31.26715772
44EIF2AK11.25581706
45SGK2231.25074197
46SGK4941.25074197
47PTK21.23984374
48ADRBK21.23522056
49PRKD21.22192114
50MOS1.20558228
51RAF11.20402005
52SYK1.17228224
53MST41.12813577
54SGK31.08596907
55MELK1.00133001
56BTK0.99854334
57ERBB30.97160480
58CDK90.96777045
59IKBKB0.96318388
60MAP3K110.93776153
61ERN10.91542808
62GRK10.88574254
63LYN0.88444348
64PRKCQ0.88050317
65ERBB40.87778046
66TNK20.87064699
67HCK0.86636709
68IRAK40.85998158
69MAPK130.85925960
70CHUK0.83645883
71PAK30.81804784
72PTK2B0.79445173
73PRKCH0.78792725
74NUAK10.78501771
75STK380.77410905
76RPS6KA40.75307147
77FGR0.74745532
78NEK20.73407890
79PIM10.72723087
80CASK0.72255606
81MAP2K40.71881845
82TTK0.71529577
83TSSK60.69380140
84FGFR10.69169805
85IRAK10.67454757
86TESK10.67413915
87BMPR1B0.63944667
88WNK40.63632838
89TLK10.62882947
90PASK0.61935959
91STK110.59944620
92CAMKK20.59600038
93INSRR0.59039519
94NEK90.58388095
95JAK20.57025300
96MUSK0.56601164
97MAP2K60.55563967
98MAPKAPK30.55067678
99ACVR1B0.54583783
100BLK0.54159154
101KSR20.53974742
102MAPK110.53589754
103FES0.52275927
104LRRK20.51632084
105WNK30.51466206
106DMPK0.51424158
107DAPK10.50833984
108TYRO30.50023484
109BUB10.49460753
110PRKCZ0.49310513
111PRKCE0.49034455
112CDK40.46285249
113PLK20.45261999
114MAP3K80.44899672
115GRK70.44342555
116HIPK20.44253959
117BRAF0.44111193
118PINK10.44048242
119CLK10.43277466
120AURKB0.43093549
121ABL10.41883876
122FYN0.40487323
123EPHA30.39822861
124MARK20.38456499
125LATS10.38181648
126CDK80.36953785
127ADRBK10.35631061
128OXSR10.34873047
129MAP3K40.33533266
130MAPK120.33501834
131SIK20.32454864
132INSR0.32310534
133IGF1R0.32005230
134SGK10.31944268
135STK240.31691369
136LIMK10.31302738
137PRKCG0.30321683
138PDGFRB0.29415269
139PLK10.28047852
140VRK10.27770519
141CAMKK10.27161210
142CSF1R0.26635791
143SIK30.25872143
144RIPK40.23690281
145GSK3A0.22717082
146STK390.22021943
147CHEK20.21747300
148SCYL20.21263649
149PRKACA0.20955747
150CSNK1G10.20908617
151PRKAA20.19973953
152CAMK40.19566526
153PRKCD0.18598473
154CAMK2A0.18099161
155MAP3K70.17940081
156PDK10.17027716
157RPS6KB20.16403450
158GRK50.16260490

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.21015392
2Graft-versus-host disease_Homo sapiens_hsa053324.91397404
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.72236188
4Fatty acid elongation_Homo sapiens_hsa000623.65102968
5T cell receptor signaling pathway_Homo sapiens_hsa046603.58951415
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.45132477
7Phototransduction_Homo sapiens_hsa047443.11154252
8Allograft rejection_Homo sapiens_hsa053303.09628314
9Antigen processing and presentation_Homo sapiens_hsa046123.06740011
10Measles_Homo sapiens_hsa051622.71818318
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.37064425
12Hematopoietic cell lineage_Homo sapiens_hsa046402.28576672
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.23018100
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.82860847
15Leishmaniasis_Homo sapiens_hsa051401.80567348
16Autoimmune thyroid disease_Homo sapiens_hsa053201.77203979
17Type I diabetes mellitus_Homo sapiens_hsa049401.73619326
18Nitrogen metabolism_Homo sapiens_hsa009101.72536300
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70783008
20Viral myocarditis_Homo sapiens_hsa054161.63041936
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54077290
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51900030
23Herpes simplex infection_Homo sapiens_hsa051681.47423917
24RNA degradation_Homo sapiens_hsa030181.45464063
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35243179
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35069709
27Osteoclast differentiation_Homo sapiens_hsa043801.33808141
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32580684
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26226182
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25074156
31Shigellosis_Homo sapiens_hsa051311.24005687
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22304300
33B cell receptor signaling pathway_Homo sapiens_hsa046621.22028498
34Pancreatic cancer_Homo sapiens_hsa052121.21968002
35Cell cycle_Homo sapiens_hsa041101.18245529
36Olfactory transduction_Homo sapiens_hsa047401.18213672
37HTLV-I infection_Homo sapiens_hsa051661.16591288
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15719093
39Apoptosis_Homo sapiens_hsa042101.14454987
40Basal transcription factors_Homo sapiens_hsa030221.12978921
41Chemokine signaling pathway_Homo sapiens_hsa040621.12731064
42Toxoplasmosis_Homo sapiens_hsa051451.12235837
43p53 signaling pathway_Homo sapiens_hsa041151.10774586
44Non-homologous end-joining_Homo sapiens_hsa034501.07287656
45Linoleic acid metabolism_Homo sapiens_hsa005911.05979161
46DNA replication_Homo sapiens_hsa030301.04991414
47Asthma_Homo sapiens_hsa053101.04481476
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02985614
49Colorectal cancer_Homo sapiens_hsa052100.99868390
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97954263
51Hepatitis B_Homo sapiens_hsa051610.96587201
52Butanoate metabolism_Homo sapiens_hsa006500.94457140
53Malaria_Homo sapiens_hsa051440.93774393
54VEGF signaling pathway_Homo sapiens_hsa043700.93083450
55TNF signaling pathway_Homo sapiens_hsa046680.92870877
56Homologous recombination_Homo sapiens_hsa034400.92135928
57Influenza A_Homo sapiens_hsa051640.91380970
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.90665185
59Sulfur relay system_Homo sapiens_hsa041220.90530323
60Nicotine addiction_Homo sapiens_hsa050330.88939173
61Prolactin signaling pathway_Homo sapiens_hsa049170.86211588
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82153686
63Base excision repair_Homo sapiens_hsa034100.81313002
64Serotonergic synapse_Homo sapiens_hsa047260.81030705
65Epstein-Barr virus infection_Homo sapiens_hsa051690.80101767
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79988735
67Dorso-ventral axis formation_Homo sapiens_hsa043200.79133098
68Taste transduction_Homo sapiens_hsa047420.78240379
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73082724
70Circadian rhythm_Homo sapiens_hsa047100.72968132
71Morphine addiction_Homo sapiens_hsa050320.72309859
72Salmonella infection_Homo sapiens_hsa051320.71149813
73RNA polymerase_Homo sapiens_hsa030200.68668188
74Renin secretion_Homo sapiens_hsa049240.67916349
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.67039614
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66635021
77Nucleotide excision repair_Homo sapiens_hsa034200.66486630
78Mismatch repair_Homo sapiens_hsa034300.66286538
79Chemical carcinogenesis_Homo sapiens_hsa052040.65756749
80Long-term potentiation_Homo sapiens_hsa047200.65362448
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65341976
82Circadian entrainment_Homo sapiens_hsa047130.64809895
83Sulfur metabolism_Homo sapiens_hsa009200.64565000
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63612020
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63513566
86Spliceosome_Homo sapiens_hsa030400.62621835
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.62109008
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59883494
89Long-term depression_Homo sapiens_hsa047300.58868528
90cAMP signaling pathway_Homo sapiens_hsa040240.58475975
91Glycerolipid metabolism_Homo sapiens_hsa005610.57573033
92Acute myeloid leukemia_Homo sapiens_hsa052210.55557472
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55463504
94Fanconi anemia pathway_Homo sapiens_hsa034600.54933469
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54023387
96Tuberculosis_Homo sapiens_hsa051520.53637791
97Viral carcinogenesis_Homo sapiens_hsa052030.53396021
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53321107
99Caffeine metabolism_Homo sapiens_hsa002320.52247292
100Non-small cell lung cancer_Homo sapiens_hsa052230.51946261
101ABC transporters_Homo sapiens_hsa020100.50631955
102RNA transport_Homo sapiens_hsa030130.50378865
103Adherens junction_Homo sapiens_hsa045200.49210556
104Thyroid cancer_Homo sapiens_hsa052160.47746611
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46749524
106Dopaminergic synapse_Homo sapiens_hsa047280.46588370
107Salivary secretion_Homo sapiens_hsa049700.46552836
108Amphetamine addiction_Homo sapiens_hsa050310.46550061
109Proteasome_Homo sapiens_hsa030500.46266979
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46071575
111Calcium signaling pathway_Homo sapiens_hsa040200.46035379
112Retinol metabolism_Homo sapiens_hsa008300.45600881
113Platelet activation_Homo sapiens_hsa046110.45251790
114Rheumatoid arthritis_Homo sapiens_hsa053230.45090033
115Hepatitis C_Homo sapiens_hsa051600.44326673
116Legionellosis_Homo sapiens_hsa051340.43891799
117Ribosome_Homo sapiens_hsa030100.42820808
118Peroxisome_Homo sapiens_hsa041460.42458906
119Small cell lung cancer_Homo sapiens_hsa052220.40861538
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40623601
121Cholinergic synapse_Homo sapiens_hsa047250.39757392
122Endocytosis_Homo sapiens_hsa041440.39450835
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.39274898
124Other glycan degradation_Homo sapiens_hsa005110.38963192
125Glioma_Homo sapiens_hsa052140.37229766
126Chronic myeloid leukemia_Homo sapiens_hsa052200.36967020
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.36793025
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36683115
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36681618
130MicroRNAs in cancer_Homo sapiens_hsa052060.36372261
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.36054285
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35606702
133Staphylococcus aureus infection_Homo sapiens_hsa051500.35565715
134Ovarian steroidogenesis_Homo sapiens_hsa049130.34828353
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34776200
136Notch signaling pathway_Homo sapiens_hsa043300.34634720
137Pyrimidine metabolism_Homo sapiens_hsa002400.33646989
138Regulation of autophagy_Homo sapiens_hsa041400.32480051
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31828858
140Glutamatergic synapse_Homo sapiens_hsa047240.31714468
141mRNA surveillance pathway_Homo sapiens_hsa030150.31431414
142GABAergic synapse_Homo sapiens_hsa047270.31106768
143FoxO signaling pathway_Homo sapiens_hsa040680.30991543
144Choline metabolism in cancer_Homo sapiens_hsa052310.30987801
145Oxidative phosphorylation_Homo sapiens_hsa001900.30153417
146Ether lipid metabolism_Homo sapiens_hsa005650.27305712
147Oocyte meiosis_Homo sapiens_hsa041140.26956849
148Protein export_Homo sapiens_hsa030600.26843465
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26779461
150MAPK signaling pathway_Homo sapiens_hsa040100.26773805
151Pertussis_Homo sapiens_hsa051330.26291319
152TGF-beta signaling pathway_Homo sapiens_hsa043500.23974398

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