CD14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.90252984
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.90252984
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.90252984
4modulation by symbiont of host immune response (GO:0052553)6.90252984
5positive regulation by symbiont of host defense response (GO:0052509)6.90252984
6modulation by symbiont of host defense response (GO:0052031)6.90252984
7response to peptidoglycan (GO:0032494)6.36479459
8neutrophil activation involved in immune response (GO:0002283)5.30804474
9macrophage activation involved in immune response (GO:0002281)5.19633669
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.06681887
11positive regulation of gamma-delta T cell activation (GO:0046645)4.76982821
12positive regulation of chemokine biosynthetic process (GO:0045080)4.70681787
13negative regulation of cell killing (GO:0031342)4.65310665
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.65310665
15microglial cell activation (GO:0001774)4.61207897
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.61164529
17response to host immune response (GO:0052572)4.61164529
18lipopolysaccharide-mediated signaling pathway (GO:0031663)4.59196766
19regulation of interferon-beta biosynthetic process (GO:0045357)4.52231083
20positive regulation of interferon-alpha production (GO:0032727)4.45302406
21immunoglobulin mediated immune response (GO:0016064)4.34822522
22respiratory burst (GO:0045730)4.32340245
23positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.29041426
24detection of other organism (GO:0098543)4.28838410
25regulation of interferon-alpha production (GO:0032647)4.27362741
26hydrogen peroxide biosynthetic process (GO:0050665)4.19149065
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.18942674
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.18632564
29response to host (GO:0075136)4.18632564
30response to host defenses (GO:0052200)4.18632564
31detection of bacterium (GO:0016045)4.05563231
32positive regulation of heat generation (GO:0031652)4.02895228
33positive regulation of cellular amide metabolic process (GO:0034250)3.95043305
34detection of molecule of bacterial origin (GO:0032490)3.94397564
35macrophage activation (GO:0042116)3.90597522
36regulation of chemokine biosynthetic process (GO:0045073)3.90208567
37regulation of mononuclear cell migration (GO:0071675)3.83938660
38regulation of fever generation (GO:0031620)3.83863761
39granulocyte activation (GO:0036230)3.82959808
40myeloid cell activation involved in immune response (GO:0002275)3.77029431
41superoxide anion generation (GO:0042554)3.76891276
42negative regulation of interleukin-17 production (GO:0032700)3.76221691
43cellular response to thyroid hormone stimulus (GO:0097067)3.70249349
44response to muramyl dipeptide (GO:0032495)3.70182165
45positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.70113473
46lymphocyte chemotaxis (GO:0048247)3.68919540
47reactive oxygen species biosynthetic process (GO:1903409)3.68909263
48positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.68640925
49regulation of myeloid leukocyte mediated immunity (GO:0002886)3.66701262
50production of molecular mediator involved in inflammatory response (GO:0002532)3.65503054
51amino sugar catabolic process (GO:0046348)3.63102380
52positive regulation of mast cell activation involved in immune response (GO:0033008)3.63066753
53positive regulation of mast cell degranulation (GO:0043306)3.63066753
54positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.61845231
55glycosphingolipid catabolic process (GO:0046479)3.57643749
56regulation of leukocyte degranulation (GO:0043300)3.55836487
57negative regulation of interleukin-12 production (GO:0032695)3.53502292
58neutrophil activation (GO:0042119)3.51676075
59detection of biotic stimulus (GO:0009595)3.51620130
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.50990073
61positive regulation of mast cell activation (GO:0033005)3.49478242
62cellular extravasation (GO:0045123)3.48489549
63regulation of macrophage chemotaxis (GO:0010758)3.46733118
64negative regulation of erythrocyte differentiation (GO:0045647)3.43291974
65positive regulation of interferon-beta production (GO:0032728)3.41815155
66regulation of gamma-delta T cell activation (GO:0046643)3.39059024
67N-acetylneuraminate metabolic process (GO:0006054)3.36302872
68positive regulation of macrophage cytokine production (GO:0060907)3.34543933
69positive regulation of NF-kappaB import into nucleus (GO:0042346)3.33836800
70antigen processing and presentation of endogenous antigen (GO:0019883)3.29309066
71positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.28678026
72positive regulation of antigen processing and presentation (GO:0002579)3.28000360
73positive regulation of chemokine production (GO:0032722)3.26553030
74regulation of mast cell degranulation (GO:0043304)3.26423821
75positive regulation of monocyte chemotaxis (GO:0090026)3.24560460
76eosinophil chemotaxis (GO:0048245)3.23035484
77regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.21775024
78negative regulation of cytokine production involved in immune response (GO:0002719)3.20400893
79glycolipid catabolic process (GO:0019377)3.19649270
80cellular response to zinc ion (GO:0071294)3.19012562
81I-kappaB phosphorylation (GO:0007252)3.18877644
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.18068804
83T-helper 1 type immune response (GO:0042088)3.17715628
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17701965
85leukocyte aggregation (GO:0070486)3.17630180
86positive regulation of leukocyte degranulation (GO:0043302)3.16742906
87regulation of interleukin-17 production (GO:0032660)3.15634583
88positive regulation of toll-like receptor signaling pathway (GO:0034123)3.13792944
89B cell mediated immunity (GO:0019724)3.12168247
90regulation of interleukin-8 biosynthetic process (GO:0045414)3.11664043
91regulation of dendritic cell antigen processing and presentation (GO:0002604)3.11191605
92monocyte chemotaxis (GO:0002548)3.09732405
93regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.09485178
94oligosaccharide catabolic process (GO:0009313)3.09119241
95cellular response to type I interferon (GO:0071357)3.08622983
96type I interferon signaling pathway (GO:0060337)3.08622983
97regulation of mast cell activation involved in immune response (GO:0033006)3.06194368
98regulation of heat generation (GO:0031650)3.05189455
99positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.04845170
100regulation of mast cell activation (GO:0033003)3.04160749
101positive regulation of interleukin-10 production (GO:0032733)3.03619366
102response to type I interferon (GO:0034340)3.03473055
103positive regulation of lymphocyte migration (GO:2000403)3.03300208
104regulation of antigen processing and presentation (GO:0002577)3.03118438
105positive regulation of interleukin-12 production (GO:0032735)3.03016809
106neutrophil chemotaxis (GO:0030593)3.02760258
107regulation of B cell receptor signaling pathway (GO:0050855)3.00019423
108interferon-gamma-mediated signaling pathway (GO:0060333)2.99557740
109positive regulation of interleukin-6 production (GO:0032755)2.99120044
110positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.98740487
111neutrophil migration (GO:1990266)2.94317387
112macrophage differentiation (GO:0030225)2.94226105
113cellular response to interferon-beta (GO:0035458)2.93719306
114response to thyroid hormone (GO:0097066)2.93284310
115regulation of T cell tolerance induction (GO:0002664)2.93169267
116regulation of heterotypic cell-cell adhesion (GO:0034114)2.93136457
117barbed-end actin filament capping (GO:0051016)2.92991565
118detection of external biotic stimulus (GO:0098581)2.92213983
119neutrophil mediated immunity (GO:0002446)2.92131993
120negative regulation of myeloid cell apoptotic process (GO:0033033)2.92054140
121* positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.92052330
122defense response to protozoan (GO:0042832)2.92030120
123NIK/NF-kappaB signaling (GO:0038061)2.91840446
124response to interferon-beta (GO:0035456)2.91298250
125myeloid dendritic cell differentiation (GO:0043011)2.90785170
126antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89921444
127leukocyte mediated cytotoxicity (GO:0001909)2.88825566
128regulation of regulated secretory pathway (GO:1903305)2.88584730
129positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.88288158
130regulation of T-helper 1 cell differentiation (GO:0045625)2.88073131
131eosinophil migration (GO:0072677)2.87444493
132germinal center formation (GO:0002467)2.86893593
133regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.86859341
134negative regulation of lymphocyte mediated immunity (GO:0002707)2.86475509
135negative regulation of leukocyte mediated immunity (GO:0002704)2.86095982
136ceramide catabolic process (GO:0046514)2.85182195
137myeloid leukocyte activation (GO:0002274)2.84419516
138phagosome maturation (GO:0090382)2.83427176
139regulation of T-helper 2 cell differentiation (GO:0045628)2.81959204
140myeloid dendritic cell activation (GO:0001773)2.78466689
141regulation of tolerance induction (GO:0002643)2.77237318
142leukocyte migration involved in inflammatory response (GO:0002523)2.72070560
143response to protozoan (GO:0001562)2.71415365
144regulation of superoxide anion generation (GO:0032928)2.70652652
145regulation of podosome assembly (GO:0071801)2.65985345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.86100105
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.19083767
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.24907402
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.66504907
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.41567463
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.90295283
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.86924156
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72328274
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.42880176
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.39691506
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15818812
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.12724150
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.99942995
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86379119
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65881928
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59686557
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.57996343
18* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44406775
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32622842
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24201427
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16122165
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11271819
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.05199039
24* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.99439384
25* SPI1_23547873_ChIP-Seq_NB4_Human1.96833523
26LXR_22292898_ChIP-Seq_THP-1_Human1.84817170
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.81103886
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78315589
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75561498
30* VDR_24787735_ChIP-Seq_THP-1_Human1.74501912
31PU_27001747_Chip-Seq_BMDM_Mouse1.73853449
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72203088
33CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66103720
34* VDR_24763502_ChIP-Seq_THP-1_Human1.60724347
35SPI1_23127762_ChIP-Seq_K562_Human1.60537343
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57062682
37RUNX_20019798_ChIP-Seq_JUKART_Human1.55841059
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55414996
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54853073
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.52694743
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48589013
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.45589749
43KDM2B_26808549_Chip-Seq_DND41_Human1.44928795
44CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44017675
45MYC_22102868_ChIP-Seq_BL_Human1.41290722
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.38640485
47MYB_26560356_Chip-Seq_TH2_Human1.38261363
48* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35064937
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34774978
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34585357
51SCL_19346495_ChIP-Seq_HPC-7_Human1.33921693
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32553290
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.29918988
54MAF_26560356_Chip-Seq_TH2_Human1.28261579
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25071119
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23231530
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22979238
58* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22271528
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22218179
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21738700
61MAF_26560356_Chip-Seq_TH1_Human1.21284338
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18670743
63BCL6_27268052_Chip-Seq_Bcells_Human1.17941653
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17911264
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17241234
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.13501063
67* BCOR_27268052_Chip-Seq_Bcells_Human1.13373347
68* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11521563
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10333836
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09184827
71GATA3_26560356_Chip-Seq_TH2_Human1.07016004
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06117767
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05275210
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04489855
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03970411
76TFEB_21752829_ChIP-Seq_HELA_Human1.02792110
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02408544
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02408544
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01673832
80EGR1_19032775_ChIP-ChIP_M12_Human1.01379127
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01263302
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01112195
83* SOX2_20726797_ChIP-Seq_SW620_Human0.99966439
84STAT1_20625510_ChIP-Seq_HELA_Human0.99941632
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98427453
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97765846
87* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97324020
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97225230
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96724218
90TRIM28_21343339_ChIP-Seq_HEK293_Human0.95954566
91MYB_26560356_Chip-Seq_TH1_Human0.95604520
92GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95017993
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94559208
94VDR_21846776_ChIP-Seq_THP-1_Human0.94289034
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94084868
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93583161
97GATA3_27048872_Chip-Seq_THYMUS_Human0.93017730
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90915712
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90867625
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90078757
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89960639
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89372669
103* ELF1_20517297_ChIP-Seq_JURKAT_Human0.88099763
104IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87628551
105GATA1_22025678_ChIP-Seq_K562_Human0.86185759
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85575749
107RACK7_27058665_Chip-Seq_MCF-7_Human0.85008429
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85008214
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85008214
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84014649
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81829985
112CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80579667
113CJUN_26792858_Chip-Seq_BT549_Human0.79871382
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.77740914
115UTX_26944678_Chip-Seq_JUKART_Human0.77357639
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.76135493
117* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75971120
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73743501
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71641224
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70643131
121* GATA2_19941826_ChIP-Seq_K562_Human0.70573031
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.69836598
123* SPI1_20517297_ChIP-Seq_HL60_Human0.69508053
124* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68524547
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.67362410
126TCF7_22412390_ChIP-Seq_EML_Mouse0.64045429
127GATA1_19941826_ChIP-Seq_K562_Human0.61506506
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.60294781
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.60083539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.23915554
2MP0001835_abnormal_antigen_presentation4.13198741
3* MP0009785_altered_susceptibility_to3.91933122
4MP0002148_abnormal_hypersensitivity_rea3.88507836
5MP0006082_CNS_inflammation3.72530571
6MP0003303_peritoneal_inflammation3.71975440
7MP0003724_increased_susceptibility_to3.44101698
8* MP0002419_abnormal_innate_immunity3.41088281
9MP0005058_abnormal_lysosome_morphology3.30082291
10MP0005000_abnormal_immune_tolerance3.29696820
11* MP0005025_abnormal_response_to2.96157769
12* MP0002452_abnormal_antigen_presenting2.52246216
13MP0005387_immune_system_phenotype2.50017507
14MP0001790_abnormal_immune_system2.50017507
15MP0004510_myositis2.45593974
16MP0001533_abnormal_skeleton_physiology2.40163828
17* MP0002723_abnormal_immune_serum2.36664864
18MP0001800_abnormal_humoral_immune2.33283480
19MP0009764_decreased_sensitivity_to2.24401906
20MP0003075_altered_response_to2.20003363
21MP0000343_altered_response_to2.17580015
22MP0005167_abnormal_blood-brain_barrier2.14729935
23MP0005671_abnormal_response_to2.13256688
24MP0000685_abnormal_immune_system2.12157399
25MP0005464_abnormal_platelet_physiology2.11757567
26* MP0001819_abnormal_immune_cell2.05596470
27* MP0002420_abnormal_adaptive_immunity2.02723590
28MP0004947_skin_inflammation2.01080691
29MP0002139_abnormal_hepatobiliary_system2.00614285
30MP0003448_altered_tumor_morphology1.97092993
31MP0003172_abnormal_lysosome_physiology1.95415962
32* MP0001845_abnormal_inflammatory_respons1.92114740
33MP0001853_heart_inflammation1.88928776
34MP0002405_respiratory_system_inflammati1.87740397
35MP0003806_abnormal_nucleotide_metabolis1.81719331
36MP0009278_abnormal_bone_marrow1.78812541
37* MP0008469_abnormal_protein_level1.76129921
38MP0003191_abnormal_cellular_cholesterol1.74057038
39MP0005166_decreased_susceptibility_to1.73571545
40MP0000604_amyloidosis1.73396528
41MP0010155_abnormal_intestine_physiology1.69194114
42MP0003690_abnormal_glial_cell1.66740474
43MP0002006_tumorigenesis1.61309265
44MP0002998_abnormal_bone_remodeling1.59226795
45MP0000858_altered_metastatic_potential1.53752392
46MP0009333_abnormal_splenocyte_physiolog1.50884804
47MP0005310_abnormal_salivary_gland1.47892780
48MP0009840_abnormal_foam_cell1.45519589
49MP0005164_abnormal_response_to1.42253515
50MP0003300_gastrointestinal_ulcer1.41152087
51MP0005451_abnormal_body_composition1.36513748
52MP0000716_abnormal_immune_system1.34750164
53MP0002277_abnormal_respiratory_mucosa1.28636135
54MP0003195_calcinosis1.24223938
55MP0002254_reproductive_system_inflammat1.23365647
56MP0005397_hematopoietic_system_phenotyp1.20214532
57MP0001545_abnormal_hematopoietic_system1.20214532
58MP0003329_amyloid_beta_deposits1.18452081
59MP0005390_skeleton_phenotype1.15922814
60MP0002398_abnormal_bone_marrow1.15859279
61MP0005365_abnormal_bile_salt1.14461705
62MP0005076_abnormal_cell_differentiation1.10548585
63MP0009763_increased_sensitivity_to1.06481388
64MP0003186_abnormal_redox_activity1.05611835
65MP0002429_abnormal_blood_cell1.05412004
66MP0000689_abnormal_spleen_morphology1.04248816
67MP0004782_abnormal_surfactant_physiolog1.04196292
68MP0002933_joint_inflammation1.00951222
69MP0003453_abnormal_keratinocyte_physiol1.00810967
70MP0004883_abnormal_blood_vessel0.95742559
71MP0000249_abnormal_blood_vessel0.94907934
72MP0002332_abnormal_exercise_endurance0.94763371
73MP0001851_eye_inflammation0.94676586
74MP0002722_abnormal_immune_system0.89101696
75MP0006054_spinal_hemorrhage0.88245612
76MP0003566_abnormal_cell_adhesion0.87340985
77MP0004858_abnormal_nervous_system0.80004086
78MP0010352_gastrointestinal_tract_polyps0.79681194
79MP0010307_abnormal_tumor_latency0.79625643
80MP0003183_abnormal_peptide_metabolism0.77471582
81MP0002837_dystrophic_cardiac_calcinosis0.77104301
82MP0003763_abnormal_thymus_physiology0.75066002
83MP0003656_abnormal_erythrocyte_physiolo0.74211155
84MP0008260_abnormal_autophagy0.74004310
85MP0002132_abnormal_respiratory_system0.73690713
86MP0008874_decreased_physiological_sensi0.72993737
87MP0001542_abnormal_bone_strength0.71297727
88MP0005257_abnormal_intraocular_pressure0.71292389
89MP0000465_gastrointestinal_hemorrhage0.70543718
90MP0005023_abnormal_wound_healing0.70018723
91MP0009765_abnormal_xenobiotic_induced0.69314607
92MP0002166_altered_tumor_susceptibility0.68557282
93MP0008004_abnormal_stomach_pH0.68475782
94MP0002138_abnormal_hepatobiliary_system0.67484592
95MP0000920_abnormal_myelination0.67379688
96MP0003279_aneurysm0.67124288
97MP0003866_abnormal_defecation0.66836036
98* MP0003795_abnormal_bone_structure0.66443231
99MP0008873_increased_physiological_sensi0.66169799
100MP0002136_abnormal_kidney_physiology0.65916934
101MP0003091_abnormal_cell_migration0.65916845
102MP0005165_increased_susceptibility_to0.60677273
103* MP0003828_pulmonary_edema0.60016645
104MP0002295_abnormal_pulmonary_circulatio0.59767697
105MP0003045_fibrosis0.59536612
106MP0005083_abnormal_biliary_tract0.58802432
107MP0000569_abnormal_digit_pigmentation0.58793339
108MP0001849_ear_inflammation0.57337044
109MP0005584_abnormal_enzyme/coenzyme_acti0.57038903
110MP0001881_abnormal_mammary_gland0.57019671
111MP0003634_abnormal_glial_cell0.56887200
112MP0000371_diluted_coat_color0.55723621
113MP0001873_stomach_inflammation0.53612354
114MP0001663_abnormal_digestive_system0.53200838
115MP0000767_abnormal_smooth_muscle0.52879753
116MP0000490_abnormal_crypts_of0.52671711
117MP0005319_abnormal_enzyme/_coenzyme0.51057490
118MP0000609_abnormal_liver_physiology0.50810366
119MP0005595_abnormal_vascular_smooth0.49329597

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.97618136
2Eczematoid dermatitis (HP:0000976)7.20877668
3Recurrent bacterial skin infections (HP:0005406)7.17220887
4Recurrent gram-negative bacterial infections (HP:0005420)6.33709080
5Systemic lupus erythematosus (HP:0002725)6.01978966
6Abnormality of macrophages (HP:0004311)5.31395641
7Mediastinal lymphadenopathy (HP:0100721)5.25162783
8Stomatitis (HP:0010280)5.20840663
9Increased cerebral lipofuscin (HP:0011813)5.01083188
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.90664485
11Vacuolated lymphocytes (HP:0001922)4.85203817
12Orchitis (HP:0100796)4.42333017
13Gingivitis (HP:0000230)4.39814891
14Elevated erythrocyte sedimentation rate (HP:0003565)4.26114479
15Myositis (HP:0100614)4.22832409
16Glomerulonephritis (HP:0000099)4.17476331
17Optic neuritis (HP:0100653)4.16662864
18Retrobulbar optic neuritis (HP:0100654)4.16662864
19Recurrent skin infections (HP:0001581)4.04002508
20Axonal loss (HP:0003447)4.00859058
21Obstructive lung disease (HP:0006536)3.90299369
22Chronic obstructive pulmonary disease (HP:0006510)3.90299369
23Autoimmune thrombocytopenia (HP:0001973)3.77276654
24Thick nail (HP:0001805)3.73514685
25Mutism (HP:0002300)3.70992170
26Pustule (HP:0200039)3.68465936
27Disinhibition (HP:0000734)3.54710415
28Prostate neoplasm (HP:0100787)3.51506858
29Dysostosis multiplex (HP:0000943)3.42636761
30Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.37799803
31Interstitial pulmonary disease (HP:0006530)3.32893265
32Recurrent fungal infections (HP:0002841)3.27945100
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.18934291
34Abnormality of glycosphingolipid metabolism (HP:0004343)3.15702164
35Abnormality of glycolipid metabolism (HP:0010969)3.15702164
36Abnormality of liposaccharide metabolism (HP:0010968)3.15702164
37Basal ganglia calcification (HP:0002135)3.14073051
38Vasculitis (HP:0002633)3.13025696
39Cellulitis (HP:0100658)3.02609844
40Neurofibrillary tangles (HP:0002185)2.99792131
41Urticaria (HP:0001025)2.98741862
42Increased serum ferritin (HP:0003281)2.92301577
43Agnosia (HP:0010524)2.88328454
44Periodontitis (HP:0000704)2.87425015
45Pulmonary infiltrates (HP:0002113)2.86348753
46Nephritis (HP:0000123)2.84333014
47Abnormality of complement system (HP:0005339)2.76264384
48Recurrent viral infections (HP:0004429)2.70851689
49Myocardial infarction (HP:0001658)2.61590035
50Increased IgM level (HP:0003496)2.58743847
51Hematochezia (HP:0002573)2.58121806
52Urinary glycosaminoglycan excretion (HP:0003541)2.58002697
53Mucopolysacchariduria (HP:0008155)2.58002697
54Osteolytic defects of the hand bones (HP:0009699)2.57621670
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.57621670
56Tetraparesis (HP:0002273)2.56324302
57Neuronal loss in central nervous system (HP:0002529)2.54959308
58Recurrent pneumonia (HP:0006532)2.54238932
59Complement deficiency (HP:0004431)2.50003293
60Osteomyelitis (HP:0002754)2.47445360
61Abnormality of iron homeostasis (HP:0011031)2.44179393
62Keratoconjunctivitis sicca (HP:0001097)2.43477721
63Progressive visual loss (HP:0000529)2.42610566
64Meningitis (HP:0001287)2.39069999
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38968465
66Abnormality of polysaccharide metabolism (HP:0011012)2.38968465
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38968465
68Petechiae (HP:0000967)2.38439881
69Nuclear cataract (HP:0100018)2.38212212
70Leukocytosis (HP:0001974)2.37344586
71Hepatosplenomegaly (HP:0001433)2.36420507
72Progressive neurologic deterioration (HP:0002344)2.32834099
73Malnutrition (HP:0004395)2.32507376
74Upper motor neuron abnormality (HP:0002127)2.29696803
75Arterial thrombosis (HP:0004420)2.27048004
76Premature loss of primary teeth (HP:0006323)2.22338414
77Keratoconjunctivitis (HP:0001096)2.19776804
78Encephalitis (HP:0002383)2.19361873
79Pulmonary embolism (HP:0002204)2.18920455
80Inappropriate behavior (HP:0000719)2.18576821
81Apathy (HP:0000741)2.16309183
82Bone pain (HP:0002653)2.15890485
83Increased IgE level (HP:0003212)2.15807623
84Retinal atrophy (HP:0001105)2.13453718
85Pathologic fracture (HP:0002756)2.12828705
86Cerebral inclusion bodies (HP:0100314)2.12247396
87Epistaxis (HP:0000421)2.11862660
88Joint hemorrhage (HP:0005261)2.11260649
89Chronic mucocutaneous candidiasis (HP:0002728)2.10900383
90Recurrent cutaneous fungal infections (HP:0011370)2.10900383
91Recurrent lower respiratory tract infections (HP:0002783)2.08278402
92Poor head control (HP:0002421)2.07737034
93Esophageal neoplasm (HP:0100751)2.06386247
94Neoplasm of head and neck (HP:0012288)2.06386247
95Spontaneous hematomas (HP:0007420)2.04032954
96Personality changes (HP:0000751)2.02866082
97Anorexia (HP:0002039)2.02698774
98Polyneuropathy (HP:0001271)2.00491199
99Abnormality of the pericardium (HP:0001697)2.00125324
100Hemoptysis (HP:0002105)2.00002526
101Nausea (HP:0002018)1.98565067
102Abnormality of transition element cation homeostasis (HP:0011030)1.96594468
103Episodic fever (HP:0001954)1.96045794
104Dementia (HP:0000726)1.95953442
105Abnormality of the prostate (HP:0008775)1.95584056
106Hypergammaglobulinemia (HP:0010702)1.94570286
107Loss of speech (HP:0002371)1.93457598
108Prolonged bleeding time (HP:0003010)1.92840284
109Metaphyseal irregularity (HP:0003025)1.92574826
110Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92480765
111Asymmetric septal hypertrophy (HP:0001670)1.91889228
112Amyloidosis (HP:0011034)1.89686359
113Abnormality of the pleura (HP:0002103)1.89598519
114Memory impairment (HP:0002354)1.89196738
115Conjunctival telangiectasia (HP:0000524)1.88664147
116Gastrointestinal infarctions (HP:0005244)1.88559364
117T lymphocytopenia (HP:0005403)1.88531592
118Purpura (HP:0000979)1.88053912
119Peritonitis (HP:0002586)1.85765622
120Arthralgia (HP:0002829)1.85064352
121Increased CSF protein (HP:0002922)1.85055358
122Gingival bleeding (HP:0000225)1.84372658
123Sepsis (HP:0100806)1.84223018
124Peripheral demyelination (HP:0011096)1.83885028
125Inflammation of the large intestine (HP:0002037)1.83070316
126Vertebral compression fractures (HP:0002953)1.82405841
127J-shaped sella turcica (HP:0002680)1.81080018
128Skin ulcer (HP:0200042)1.80265494
129Diminished motivation (HP:0000745)1.79295288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.60868208
2BLK4.50105092
3RIPK44.40411295
4TBK13.76285193
5IRAK33.72109766
6IRAK43.11519031
7TYK22.91141413
8PBK2.75651960
9IKBKE2.68822023
10IKBKB2.48172849
11TXK2.37777471
12ERN12.19128631
13PRPF4B2.15012322
14MAP4K12.13596898
15TAOK11.94866998
16TGFBR21.91163875
17KIT1.89840028
18JAK31.88845746
19FGR1.82124686
20CSK1.76419736
21PIM21.74494695
22JAK11.74086515
23TNK21.71104197
24GRK71.69472379
25TAOK21.62609574
26CHUK1.57228004
27EPHB11.55460962
28NEK91.49646504
29CSF1R1.40694673
30ZAP701.39193786
31HCK1.31926509
32CAMKK21.30198413
33LYN1.29074912
34MAP3K131.28185295
35MATK1.25805197
36DDR21.25509980
37NME21.20928848
38STK101.19225769
39SYK1.18431711
40BMX1.15791692
41CDC42BPA1.12631944
42ABL21.11252243
43JAK21.10550433
44BTK1.09772412
45BMPR21.09706404
46SIK31.04239613
47TESK21.03541836
48EIF2AK21.02257058
49RPS6KA41.00507849
50LCK1.00282238
51ACVR1B0.97645190
52MST40.92671499
53MAP3K110.91781199
54PIM10.91339132
55FES0.91031532
56PRKCD0.90670914
57GRK60.90295068
58MARK30.90139564
59YES10.84703769
60MAP3K30.82423134
61MST1R0.82319769
62EGFR0.81560406
63MOS0.80976605
64TAOK30.74852789
65TRIB30.74297424
66KSR20.73169813
67TEC0.72099045
68EPHA30.72062439
69MARK20.71096823
70MAP3K50.70811305
71IRAK10.70211675
72ABL10.69724014
73ADRBK20.67340172
74PRKD20.64521932
75RIPK10.63153377
76MAPK120.62765226
77SIK10.62285832
78FGFR40.61317635
79MAPK70.60475051
80MAP2K30.58127841
81SIK20.56688560
82MAP2K60.56639600
83RPS6KC10.56529156
84RPS6KL10.56529156
85DAPK20.56268139
86MAP3K10.56182031
87FGFR30.55751836
88TGFBR10.53352383
89TRPM70.53306122
90IRAK20.51840336
91CAMKK10.49852505
92CAMK1D0.49808359
93STK30.49718595
94PTK60.49607426
95MAP3K60.49603854
96MAP3K120.47807343
97ERBB40.47364454
98ARAF0.47102913
99LRRK20.46143820
100BMPR1B0.46080633
101ERBB30.45378485
102CLK10.44916909
103MAPKAPK20.42973892
104RPS6KA20.42312802
105FYN0.42259814
106ITK0.41837062
107PDGFRB0.40897992
108STK40.39958754
109CDK60.35715512
110TESK10.35676225
111PAK40.35378582
112CAMK1G0.32661862
113GSK3A0.32418454
114IGF1R0.32328745
115TTN0.30390473
116SGK30.29221634
117DAPK30.29202748
118PIK3CG0.27693791
119KSR10.27500783
120MAP2K40.25809256
121PRKCQ0.25620340
122INSR0.25361058
123MAP3K100.23197112
124RPS6KA60.22531676
125MAPK40.22523670
126PRKG20.21988004
127PDK10.21755647
128PDPK10.21532157
129MAP2K20.20951524
130PLK20.20362198
131SRC0.20253403

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.98249014
2Leishmaniasis_Homo sapiens_hsa051403.71160299
3Graft-versus-host disease_Homo sapiens_hsa053323.54904285
4* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.87847667
5* Legionellosis_Homo sapiens_hsa051342.75684983
6Malaria_Homo sapiens_hsa051442.66172716
7Rheumatoid arthritis_Homo sapiens_hsa053232.62454716
8Osteoclast differentiation_Homo sapiens_hsa043802.50923119
9* Pertussis_Homo sapiens_hsa051332.48072420
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.43006367
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38410728
12* NF-kappa B signaling pathway_Homo sapiens_hsa040642.37584792
13* Tuberculosis_Homo sapiens_hsa051522.33449269
14Allograft rejection_Homo sapiens_hsa053302.26894051
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23850717
16Lysosome_Homo sapiens_hsa041422.16380092
17Type I diabetes mellitus_Homo sapiens_hsa049402.15087993
18TNF signaling pathway_Homo sapiens_hsa046681.95424192
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94082880
20Measles_Homo sapiens_hsa051621.93291771
21Asthma_Homo sapiens_hsa053101.91004475
22* Salmonella infection_Homo sapiens_hsa051321.85949390
23African trypanosomiasis_Homo sapiens_hsa051431.83949419
24* Phagosome_Homo sapiens_hsa041451.81465181
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.76009373
26Influenza A_Homo sapiens_hsa051641.70589010
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.57230597
28Toxoplasmosis_Homo sapiens_hsa051451.51910192
29Other glycan degradation_Homo sapiens_hsa005111.49775403
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43528722
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.41401202
32B cell receptor signaling pathway_Homo sapiens_hsa046621.37592939
33* Hematopoietic cell lineage_Homo sapiens_hsa046401.37099520
34Herpes simplex infection_Homo sapiens_hsa051681.33564731
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26978481
36Prion diseases_Homo sapiens_hsa050201.26650100
37Chemokine signaling pathway_Homo sapiens_hsa040621.24816874
38Apoptosis_Homo sapiens_hsa042101.22375601
39Shigellosis_Homo sapiens_hsa051311.19269229
40Antigen processing and presentation_Homo sapiens_hsa046121.17899100
41Complement and coagulation cascades_Homo sapiens_hsa046101.13024287
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.10271841
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05326672
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03729364
45* Amoebiasis_Homo sapiens_hsa051461.02589208
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00106579
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99886896
48Hepatitis B_Homo sapiens_hsa051610.99107039
49Hepatitis C_Homo sapiens_hsa051600.93294844
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89333538
51Autoimmune thyroid disease_Homo sapiens_hsa053200.87742246
52Viral myocarditis_Homo sapiens_hsa054160.84790230
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.84749499
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83415196
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77588496
56Bladder cancer_Homo sapiens_hsa052190.67808573
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65336527
58Galactose metabolism_Homo sapiens_hsa000520.63770584
59Collecting duct acid secretion_Homo sapiens_hsa049660.61283808
60Mineral absorption_Homo sapiens_hsa049780.60847024
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.56709990
62T cell receptor signaling pathway_Homo sapiens_hsa046600.56228626
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55427002
64* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52928079
65PPAR signaling pathway_Homo sapiens_hsa033200.50818002
66Chronic myeloid leukemia_Homo sapiens_hsa052200.47796157
67HIF-1 signaling pathway_Homo sapiens_hsa040660.47252228
68Platelet activation_Homo sapiens_hsa046110.46726321
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.46397076
70Pancreatic cancer_Homo sapiens_hsa052120.45796837
71Acute myeloid leukemia_Homo sapiens_hsa052210.44629734
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.42173556
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42124650
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.40373962
75Epstein-Barr virus infection_Homo sapiens_hsa051690.40061100
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39792792
77Type II diabetes mellitus_Homo sapiens_hsa049300.39133196
78Prolactin signaling pathway_Homo sapiens_hsa049170.38789008
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.38667644
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38550455
81GnRH signaling pathway_Homo sapiens_hsa049120.36786880
82Primary immunodeficiency_Homo sapiens_hsa053400.36727950
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36347904
84Caffeine metabolism_Homo sapiens_hsa002320.34402492
85Endocytosis_Homo sapiens_hsa041440.34019199
86Proteoglycans in cancer_Homo sapiens_hsa052050.33919108
87Sphingolipid metabolism_Homo sapiens_hsa006000.31932758
88Small cell lung cancer_Homo sapiens_hsa052220.31906825
89Fructose and mannose metabolism_Homo sapiens_hsa000510.29989360
90Non-small cell lung cancer_Homo sapiens_hsa052230.29552053
91Synaptic vesicle cycle_Homo sapiens_hsa047210.26227502
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23444978
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22506846
94Viral carcinogenesis_Homo sapiens_hsa052030.22291397
95VEGF signaling pathway_Homo sapiens_hsa043700.22050874
96Vibrio cholerae infection_Homo sapiens_hsa051100.21115945
97Systemic lupus erythematosus_Homo sapiens_hsa053220.20358583
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20006591
99* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19844778
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.19060497
101Renin-angiotensin system_Homo sapiens_hsa046140.18744081
102Insulin resistance_Homo sapiens_hsa049310.18197872
103Steroid biosynthesis_Homo sapiens_hsa001000.17536718
104Dorso-ventral axis formation_Homo sapiens_hsa043200.17412390
105Estrogen signaling pathway_Homo sapiens_hsa049150.16990978
106Arachidonic acid metabolism_Homo sapiens_hsa005900.16594012
107Renal cell carcinoma_Homo sapiens_hsa052110.13961053
108* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13605231
109Ether lipid metabolism_Homo sapiens_hsa005650.13504781
110HTLV-I infection_Homo sapiens_hsa051660.13071482
111Notch signaling pathway_Homo sapiens_hsa043300.12885143
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11417712
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10816881
114FoxO signaling pathway_Homo sapiens_hsa040680.07446876

Most similar genes based on co-expression Upload to Enrichr

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