CCT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.84773947
2DNA unwinding involved in DNA replication (GO:0006268)4.81326409
3DNA replication initiation (GO:0006270)4.67983952
4nucleobase biosynthetic process (GO:0046112)4.67842824
5DNA strand elongation (GO:0022616)4.60791675
6formation of translation preinitiation complex (GO:0001731)4.60611257
7purine nucleobase biosynthetic process (GO:0009113)4.50332045
8telomere maintenance via semi-conservative replication (GO:0032201)4.41185806
9DNA replication checkpoint (GO:0000076)4.26270375
10maturation of SSU-rRNA (GO:0030490)4.21282970
11IMP biosynthetic process (GO:0006188)4.16371260
12sister chromatid segregation (GO:0000819)4.03428862
13telomere maintenance via recombination (GO:0000722)3.96876048
14mitotic metaphase plate congression (GO:0007080)3.95388269
15chromatin remodeling at centromere (GO:0031055)3.94088479
16DNA replication-dependent nucleosome organization (GO:0034723)3.93458603
17DNA replication-dependent nucleosome assembly (GO:0006335)3.93458603
18CENP-A containing nucleosome assembly (GO:0034080)3.92955745
19ribosome assembly (GO:0042255)3.91684764
20mitotic sister chromatid cohesion (GO:0007064)3.91449338
21ribosomal small subunit assembly (GO:0000028)3.89067840
22nuclear pore organization (GO:0006999)3.86124311
23ribosome biogenesis (GO:0042254)3.85469302
24mitotic recombination (GO:0006312)3.85030919
25protein localization to kinetochore (GO:0034501)3.79404823
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78673593
27mitotic nuclear envelope disassembly (GO:0007077)3.78045748
28mitotic chromosome condensation (GO:0007076)3.74211817
29proteasome assembly (GO:0043248)3.73231548
30folic acid-containing compound biosynthetic process (GO:0009396)3.73053162
31pore complex assembly (GO:0046931)3.70397170
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69088227
33IMP metabolic process (GO:0046040)3.67900909
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67729346
35non-recombinational repair (GO:0000726)3.66611770
36double-strand break repair via nonhomologous end joining (GO:0006303)3.66611770
37telomere maintenance via telomere lengthening (GO:0010833)3.66271781
38spliceosomal snRNP assembly (GO:0000387)3.65753385
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.65699650
40ribosomal large subunit biogenesis (GO:0042273)3.65263985
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.65258336
42cullin deneddylation (GO:0010388)3.63555234
43DNA replication-independent nucleosome organization (GO:0034724)3.62875847
44DNA replication-independent nucleosome assembly (GO:0006336)3.62875847
45ribonucleoprotein complex biogenesis (GO:0022613)3.61357205
46DNA ligation (GO:0006266)3.58952012
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.55275605
48nuclear pore complex assembly (GO:0051292)3.52028019
49membrane disassembly (GO:0030397)3.51515010
50nuclear envelope disassembly (GO:0051081)3.51515010
51establishment of viral latency (GO:0019043)3.50505981
52metaphase plate congression (GO:0051310)3.49861357
53establishment of integrated proviral latency (GO:0075713)3.47853972
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.45799080
55negative regulation of ligase activity (GO:0051352)3.45799080
56amino acid activation (GO:0043038)3.44280610
57tRNA aminoacylation (GO:0043039)3.44280610
58protein deneddylation (GO:0000338)3.43356880
59DNA deamination (GO:0045006)3.41024552
60rRNA processing (GO:0006364)3.40758954
61kinetochore organization (GO:0051383)3.38366668
62attachment of spindle microtubules to kinetochore (GO:0008608)3.37523839
63regulation of centriole replication (GO:0046599)3.37175814
64regulation of chromosome segregation (GO:0051983)3.35957993
65histone exchange (GO:0043486)3.35581647
66regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31268835
67regulation of mitotic metaphase/anaphase transition (GO:0030071)3.31268835
68transcription-coupled nucleotide-excision repair (GO:0006283)3.31007236
69DNA double-strand break processing (GO:0000729)3.29567817
70rRNA metabolic process (GO:0016072)3.29094976
71G1/S transition of mitotic cell cycle (GO:0000082)3.27003878
72cell cycle G1/S phase transition (GO:0044843)3.27003878
73regulation of translational fidelity (GO:0006450)3.26109670
74translational termination (GO:0006415)3.26089550
75DNA catabolic process, exonucleolytic (GO:0000738)3.25344556
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25007387
77DNA topological change (GO:0006265)3.24818663
78spliceosomal complex assembly (GO:0000245)3.23733002
79translational initiation (GO:0006413)3.23417509
80viral mRNA export from host cell nucleus (GO:0046784)3.23322663
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22890553
82viral transcription (GO:0019083)3.21606586
83pseudouridine synthesis (GO:0001522)3.21143500
84regulation of sister chromatid segregation (GO:0033045)3.20025363
85regulation of mitotic sister chromatid separation (GO:0010965)3.20025363
86regulation of mitotic sister chromatid segregation (GO:0033047)3.20025363
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20006640
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20006640
89negative regulation of sister chromatid segregation (GO:0033046)3.20006640
90negative regulation of mitotic sister chromatid separation (GO:2000816)3.20006640
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19231093
92protein localization to chromosome, centromeric region (GO:0071459)3.19182219
93negative regulation of chromosome segregation (GO:0051985)3.18032146
94establishment of chromosome localization (GO:0051303)3.17423470
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16533320
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.16533320
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16459149
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16459149
99mitotic spindle assembly checkpoint (GO:0007094)3.15553569
100spindle assembly checkpoint (GO:0071173)3.15197318
101signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14247340
102signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14247340
103signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14247340
104signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13902566
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.13902566
106mitotic sister chromatid segregation (GO:0000070)3.12499129
107DNA duplex unwinding (GO:0032508)3.12162128
108ribosomal small subunit biogenesis (GO:0042274)3.11919177
109postreplication repair (GO:0006301)3.11646974
110DNA geometric change (GO:0032392)3.11415133
111rRNA modification (GO:0000154)3.10562320
112signal transduction involved in cell cycle checkpoint (GO:0072395)3.09816824
113translational elongation (GO:0006414)3.09764270
114spindle checkpoint (GO:0031577)3.09721455
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09605587
116regulation of helicase activity (GO:0051095)3.09504078
117tRNA aminoacylation for protein translation (GO:0006418)3.07984703
118positive regulation of ligase activity (GO:0051351)3.07654532
119mitotic spindle checkpoint (GO:0071174)3.06196762
120peptidyl-arginine omega-N-methylation (GO:0035247)3.05199724
121regulation of cellular amino acid metabolic process (GO:0006521)3.05138839
122kinetochore assembly (GO:0051382)3.04987653
123maturation of 5.8S rRNA (GO:0000460)3.04765505
124chromosome segregation (GO:0007059)3.01036618
125regulation of ubiquitin-protein transferase activity (GO:0051438)3.00758552
126regulation of mitotic spindle checkpoint (GO:1903504)3.00227455
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00227455
128positive regulation of chromosome segregation (GO:0051984)2.97230294
129synapsis (GO:0007129)2.92838711
130DNA damage response, detection of DNA damage (GO:0042769)2.92670720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.45062699
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.75378055
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93797682
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65649753
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61146652
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.47392782
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.29206143
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.24401975
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18875166
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14117664
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.08655393
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.07536509
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05209699
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98843548
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95201731
16* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83144960
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.61363373
18XRN2_22483619_ChIP-Seq_HELA_Human2.53944949
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51347059
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43005677
21* VDR_23849224_ChIP-Seq_CD4+_Human2.40040145
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37067896
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23315968
24DCP1A_22483619_ChIP-Seq_HELA_Human2.22101929
25AR_21909140_ChIP-Seq_LNCAP_Human2.21544564
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13567976
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.11911763
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07533141
29GABP_19822575_ChIP-Seq_HepG2_Human2.06000521
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04211780
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04161786
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03472600
33* TTF2_22483619_ChIP-Seq_HELA_Human2.03029697
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02080875
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.99090283
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95484160
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92708592
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91154120
39ELK1_19687146_ChIP-ChIP_HELA_Human1.84372273
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79706753
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77606252
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76988514
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73979126
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70687170
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.66433414
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65320401
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63120280
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.61861664
49CIITA_25753668_ChIP-Seq_RAJI_Human1.61074850
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56678678
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55854515
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.54061412
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50399512
54KDM5A_27292631_Chip-Seq_BREAST_Human1.49693162
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49569524
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49478153
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43367618
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40773186
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39010883
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31637808
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27588896
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19954184
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19121595
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18647251
65TFEB_21752829_ChIP-Seq_HELA_Human1.18305490
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18019518
67MYC_22102868_ChIP-Seq_BL_Human1.17242028
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15055438
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13672212
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13360192
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12155567
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09127489
73* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08992968
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08784024
75MYC_18940864_ChIP-ChIP_HL60_Human1.08044168
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06692970
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05466177
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04962162
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.04631051
80EWS_26573619_Chip-Seq_HEK293_Human1.02124226
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01040369
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00662364
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96787176
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.95342333
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94884515
86* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94560585
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93305848
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.92852779
89ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88169406
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88048421
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.87183429
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86510479
93SALL1_21062744_ChIP-ChIP_HESCs_Human0.85159653
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84395587
95FUS_26573619_Chip-Seq_HEK293_Human0.83398893
96TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82653281
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82617789
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82262867
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82090230
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81841146
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.81611753
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.81590712
103* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80664155
104OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76886104
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76677154
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.76658688
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.73547354
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73225149
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73068790
110CHD1_26751641_Chip-Seq_LNCaP_Human0.71920521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.41054844
2MP0010094_abnormal_chromosome_stability5.09874355
3MP0004957_abnormal_blastocyst_morpholog5.00135618
4MP0003111_abnormal_nucleus_morphology4.55292698
5MP0003077_abnormal_cell_cycle4.20760838
6MP0008057_abnormal_DNA_replication4.19871804
7MP0008058_abnormal_DNA_repair3.95193947
8MP0008007_abnormal_cellular_replicative3.33076541
9MP0003123_paternal_imprinting3.32341430
10MP0008932_abnormal_embryonic_tissue3.14518307
11MP0008877_abnormal_DNA_methylation3.13907526
12MP0001730_embryonic_growth_arrest2.62059340
13MP0003786_premature_aging2.36865860
14MP0000350_abnormal_cell_proliferation2.34923622
15MP0010352_gastrointestinal_tract_polyps2.17266275
16MP0003121_genomic_imprinting1.98254488
17MP0002396_abnormal_hematopoietic_system1.94102733
18MP0001697_abnormal_embryo_size1.88393209
19MP0001672_abnormal_embryogenesis/_devel1.79270700
20MP0005380_embryogenesis_phenotype1.79270700
21MP0010030_abnormal_orbit_morphology1.73456210
22MP0002080_prenatal_lethality1.71802555
23MP0003984_embryonic_growth_retardation1.63827660
24MP0002085_abnormal_embryonic_tissue1.60963142
25MP0003806_abnormal_nucleotide_metabolis1.60781000
26MP0010307_abnormal_tumor_latency1.59911674
27MP0002088_abnormal_embryonic_growth/wei1.59798333
28MP0002084_abnormal_developmental_patter1.59158317
29MP0003718_maternal_effect1.56330709
30MP0000372_irregular_coat_pigmentation1.54785280
31MP0004197_abnormal_fetal_growth/weight/1.48499487
32MP0000537_abnormal_urethra_morphology1.47974093
33MP0002210_abnormal_sex_determination1.47864633
34MP0000313_abnormal_cell_death1.47385308
35MP0003567_abnormal_fetal_cardiomyocyte1.41753454
36MP0003890_abnormal_embryonic-extraembry1.37957440
37MP0000490_abnormal_crypts_of1.36828480
38MP0003315_abnormal_perineum_morphology1.35817819
39MP0002086_abnormal_extraembryonic_tissu1.30613614
40MP0001145_abnormal_male_reproductive1.29747161
41MP0002019_abnormal_tumor_incidence1.26929476
42MP0004808_abnormal_hematopoietic_stem1.26872232
43MP0000358_abnormal_cell_content/1.24113676
44MP0002160_abnormal_reproductive_system1.23394885
45MP0001293_anophthalmia1.19955083
46MP0004133_heterotaxia1.14602227
47MP0009053_abnormal_anal_canal1.14038754
48MP0006035_abnormal_mitochondrial_morpho1.13007965
49MP0001929_abnormal_gametogenesis1.11382598
50MP0003221_abnormal_cardiomyocyte_apopto1.11364991
51MP0009697_abnormal_copulation1.09233701
52MP0000653_abnormal_sex_gland1.08446498
53MP0004147_increased_porphyrin_level1.05743039
54MP0003119_abnormal_digestive_system1.04460629
55MP0006072_abnormal_retinal_apoptosis0.98515911
56MP0006054_spinal_hemorrhage0.96330971
57MP0008995_early_reproductive_senescence0.95196003
58MP0006292_abnormal_olfactory_placode0.93356206
59MP0005408_hypopigmentation0.92976781
60MP0006036_abnormal_mitochondrial_physio0.92687462
61MP0003122_maternal_imprinting0.92551066
62MP0002877_abnormal_melanocyte_morpholog0.92532811
63MP0009333_abnormal_splenocyte_physiolog0.89754733
64MP0002697_abnormal_eye_size0.89482779
65MP0001661_extended_life_span0.88735423
66MP0002111_abnormal_tail_morphology0.88560767
67MP0005389_reproductive_system_phenotype0.85766992
68MP0009672_abnormal_birth_weight0.85651907
69MP0005384_cellular_phenotype0.84470704
70MP0010234_abnormal_vibrissa_follicle0.83935205
71MP0002233_abnormal_nose_morphology0.82443178
72MP0003937_abnormal_limbs/digits/tail_de0.82295706
73MP0000703_abnormal_thymus_morphology0.82115567
74MP0000647_abnormal_sebaceous_gland0.80757507
75MP0002751_abnormal_autonomic_nervous0.80536745
76MP0003941_abnormal_skin_development0.79753997
77MP0003385_abnormal_body_wall0.77917300
78MP0002938_white_spotting0.76515606
79MP0001119_abnormal_female_reproductive0.75495287
80MP0004233_abnormal_muscle_weight0.75493005
81MP0003186_abnormal_redox_activity0.74363379
82MP0005075_abnormal_melanosome_morpholog0.74256999
83MP0005171_absent_coat_pigmentation0.73247648
84MP0001727_abnormal_embryo_implantation0.72820142
85MP0005501_abnormal_skin_physiology0.70964697
86MP0001545_abnormal_hematopoietic_system0.70533888
87MP0005397_hematopoietic_system_phenotyp0.70533888
88MP0005076_abnormal_cell_differentiation0.69815100
89MP0002102_abnormal_ear_morphology0.69661443
90MP0002090_abnormal_vision0.68332276
91MP0005266_abnormal_metabolism0.66678103
92MP0000428_abnormal_craniofacial_morphol0.65500773
93MP0003698_abnormal_male_reproductive0.64763561
94MP0005395_other_phenotype0.64680971
95MP0005499_abnormal_olfactory_system0.64380643
96MP0005394_taste/olfaction_phenotype0.64380643
97MP0001529_abnormal_vocalization0.64282430
98MP0005621_abnormal_cell_physiology0.64249354
99MP0002653_abnormal_ependyma_morphology0.64130276
100MP0009379_abnormal_foot_pigmentation0.63624047
101MP0001286_abnormal_eye_development0.63472873
102MP0009703_decreased_birth_body0.61889891
103MP0002722_abnormal_immune_system0.61476506
104MP0002269_muscular_atrophy0.59064053
105MP0002398_abnormal_bone_marrow0.58250068
106MP0003763_abnormal_thymus_physiology0.57172234
107MP0000689_abnormal_spleen_morphology0.56347955
108MP0002234_abnormal_pharynx_morphology0.56117535
109MP0000049_abnormal_middle_ear0.55689876
110MP0002009_preneoplasia0.54979492
111MP0001299_abnormal_eye_distance/0.54598877
112MP0002796_impaired_skin_barrier0.54502143
113MP0003861_abnormal_nervous_system0.54455868
114MP0003755_abnormal_palate_morphology0.54322537
115MP0003699_abnormal_female_reproductive0.53905464
116MP0005391_vision/eye_phenotype0.53731268
117MP0000858_altered_metastatic_potential0.53716677
118MP0002161_abnormal_fertility/fecundity0.53453095
119MP0003787_abnormal_imprinting0.53402381
120MP0003943_abnormal_hepatobiliary_system0.53085422
121MP0002114_abnormal_axial_skeleton0.52898114
122MP0001919_abnormal_reproductive_system0.51393100
123MP0002092_abnormal_eye_morphology0.51060570
124MP0001915_intracranial_hemorrhage0.50992984
125MP0003942_abnormal_urinary_system0.48770052
126MP0008789_abnormal_olfactory_epithelium0.48763671
127MP0000477_abnormal_intestine_morphology0.47935062
128MP0005023_abnormal_wound_healing0.46761568

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.15233291
2Reticulocytopenia (HP:0001896)3.88484116
3Breast hypoplasia (HP:0003187)3.83330691
4Colon cancer (HP:0003003)3.70817123
5Abnormality of cells of the erythroid lineage (HP:0012130)3.66245940
6Oral leukoplakia (HP:0002745)3.65308151
7Degeneration of anterior horn cells (HP:0002398)3.62512439
8Abnormality of the anterior horn cell (HP:0006802)3.62512439
9Abnormal number of erythroid precursors (HP:0012131)3.51120957
10Selective tooth agenesis (HP:0001592)3.44945110
11Medulloblastoma (HP:0002885)3.40527685
12Patellar aplasia (HP:0006443)3.24130192
13Carpal bone hypoplasia (HP:0001498)3.20407443
14Ependymoma (HP:0002888)3.20281985
15Chromsome breakage (HP:0040012)3.19011680
16Cerebral hypomyelination (HP:0006808)3.15947366
17Abnormality of the labia minora (HP:0012880)3.06184348
18Aplasia/Hypoplasia of the patella (HP:0006498)3.03556850
19Rough bone trabeculation (HP:0100670)3.02621649
20Aplastic anemia (HP:0001915)2.98902268
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93133072
2211 pairs of ribs (HP:0000878)2.91571147
23Cortical dysplasia (HP:0002539)2.90013891
24Volvulus (HP:0002580)2.89816008
25Embryonal renal neoplasm (HP:0011794)2.88246905
26Agnosia (HP:0010524)2.88112689
27Abnormality of chromosome stability (HP:0003220)2.85465725
28Meckel diverticulum (HP:0002245)2.84307168
29Abnormality of the preputium (HP:0100587)2.80315377
30Abnormality of methionine metabolism (HP:0010901)2.78559838
31Abnormality of the ileum (HP:0001549)2.71406264
32Absent thumb (HP:0009777)2.70143481
33Absent radius (HP:0003974)2.65181053
34Increased serum pyruvate (HP:0003542)2.62892331
35Abnormality of glycolysis (HP:0004366)2.62892331
36Neoplasm of the pancreas (HP:0002894)2.62798042
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.58108884
38Acute encephalopathy (HP:0006846)2.57197802
39Macrocytic anemia (HP:0001972)2.54828525
40Increased hepatocellular lipid droplets (HP:0006565)2.52814802
41Pallor (HP:0000980)2.50348955
42Premature graying of hair (HP:0002216)2.47259371
43Rhabdomyosarcoma (HP:0002859)2.47109164
44Aplasia involving forearm bones (HP:0009822)2.46001584
45Absent forearm bone (HP:0003953)2.46001584
46Horseshoe kidney (HP:0000085)2.45910706
47Duodenal stenosis (HP:0100867)2.43619852
48Small intestinal stenosis (HP:0012848)2.43619852
49Trismus (HP:0000211)2.42204777
50Cholecystitis (HP:0001082)2.41675820
51Abnormal gallbladder physiology (HP:0012438)2.41675820
52Microretrognathia (HP:0000308)2.40656294
53Abnormal lung lobation (HP:0002101)2.38933985
54Atrophy/Degeneration involving motor neurons (HP:0007373)2.34870943
55Myelodysplasia (HP:0002863)2.34093156
56Shoulder girdle muscle weakness (HP:0003547)2.31817651
57Abnormal number of incisors (HP:0011064)2.29949255
58Supernumerary spleens (HP:0009799)2.27035717
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24786614
60Sloping forehead (HP:0000340)2.22458598
61Type I transferrin isoform profile (HP:0003642)2.22324446
62Increased serum lactate (HP:0002151)2.20778480
63Irregular epiphyses (HP:0010582)2.20461130
64Cerebral edema (HP:0002181)2.19139181
65Lipid accumulation in hepatocytes (HP:0006561)2.19094895
66Missing ribs (HP:0000921)2.17161273
67Pelvic girdle muscle weakness (HP:0003749)2.15494802
68Abnormal trabecular bone morphology (HP:0100671)2.14847774
69Bone marrow hypocellularity (HP:0005528)2.13611958
70Atresia of the external auditory canal (HP:0000413)2.13203891
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13091977
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12907187
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12907187
74Neoplasm of the colon (HP:0100273)2.12009036
75Slender long bone (HP:0003100)2.11640303
76Glossoptosis (HP:0000162)2.11605468
77Proximal placement of thumb (HP:0009623)2.11464490
78Progressive external ophthalmoplegia (HP:0000590)2.09897230
79Impulsivity (HP:0100710)2.09566752
80Increased CSF lactate (HP:0002490)2.08416388
81Cellular immunodeficiency (HP:0005374)2.07503495
82Basal cell carcinoma (HP:0002671)2.06738151
83Deviation of the thumb (HP:0009603)2.05106123
84Abnormality of the duodenum (HP:0002246)2.04558871
85CNS hypomyelination (HP:0003429)2.04112044
86Triphalangeal thumb (HP:0001199)2.03053185
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02812326
88Postnatal microcephaly (HP:0005484)2.02064958
89Hypoplasia of the pons (HP:0012110)2.01574326
90Facial cleft (HP:0002006)2.01295262
91Single umbilical artery (HP:0001195)2.00973767
92Abnormality of the fetal cardiovascular system (HP:0010948)2.00973767
93Abnormal umbilical cord blood vessels (HP:0011403)2.00973767
94Pancreatic islet-cell hyperplasia (HP:0004510)2.00060273
95Acute necrotizing encephalopathy (HP:0006965)1.98585509
96Progressive macrocephaly (HP:0004481)1.98377594
97Reduced antithrombin III activity (HP:0001976)1.97586117
98Glioma (HP:0009733)1.97394243
99Abnormality of the carotid arteries (HP:0005344)1.96592694
100Secondary amenorrhea (HP:0000869)1.96223367
101Abnormality of serum amino acid levels (HP:0003112)1.96084309
102Abnormal mitochondria in muscle tissue (HP:0008316)1.93905225
103Cleft eyelid (HP:0000625)1.92794582
104Spastic diplegia (HP:0001264)1.92388320
105Multiple enchondromatosis (HP:0005701)1.92361945
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90477081
107Abnormality of alanine metabolism (HP:0010916)1.90477081
108Hyperalaninemia (HP:0003348)1.90477081
109Abnormality of the astrocytes (HP:0100707)1.89645658
110Astrocytoma (HP:0009592)1.89645658
111Choanal atresia (HP:0000453)1.89042487
112Tracheoesophageal fistula (HP:0002575)1.87863175
113Increased nuchal translucency (HP:0010880)1.86384073
114Nephroblastoma (Wilms tumor) (HP:0002667)1.86275777
115Cafe-au-lait spot (HP:0000957)1.85491696
116Ovarian neoplasm (HP:0100615)1.85472423
117Abnormality of the umbilical cord (HP:0010881)1.85319998
118Mitochondrial inheritance (HP:0001427)1.84335924
119Megaloblastic anemia (HP:0001889)1.83666805
120Microvesicular hepatic steatosis (HP:0001414)1.82238806
121Abnormality of the hip-girdle musculature (HP:0001445)1.81926254
122Abnormality of the musculature of the pelvis (HP:0001469)1.81926254
123Short middle phalanx of the 5th finger (HP:0004220)1.81779453
124Premature ovarian failure (HP:0008209)1.81586941
125Hepatic necrosis (HP:0002605)1.80665339
126Pancytopenia (HP:0001876)1.80447755
127Hepatocellular necrosis (HP:0001404)1.80404603
128Neoplasm of the adrenal gland (HP:0100631)1.79470708
129Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79178224
130Bifid tongue (HP:0010297)1.78234924
131Gonadotropin excess (HP:0000837)1.77998562
132Methylmalonic acidemia (HP:0002912)1.77514795
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77018456
134Abnormal protein N-linked glycosylation (HP:0012347)1.77018456
135Abnormal protein glycosylation (HP:0012346)1.77018456
136Abnormal glycosylation (HP:0012345)1.77018456
137Lactic acidosis (HP:0003128)1.76072959
138Ectopic kidney (HP:0000086)1.71486686
139Homocystinuria (HP:0002156)1.70525210
140Abnormality of homocysteine metabolism (HP:0010919)1.70525210
141Embryonal neoplasm (HP:0002898)1.69717768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.11409587
2WEE14.31707839
3CDC74.13604071
4EIF2AK13.64897468
5TSSK63.36873456
6NEK12.88684971
7STK162.74754519
8SRPK12.63893126
9ACVR1B2.60200593
10TRIM282.54778658
11BRSK22.36425294
12PASK2.23513924
13NEK22.18640294
14TTK2.13540667
15EIF2AK32.11155218
16MKNK12.08132201
17PLK11.98597153
18PLK41.98563408
19VRK21.91358295
20PLK31.91127327
21VRK11.70866439
22NME21.69481507
23ATR1.65818684
24TESK21.60055243
25BRSK11.59616300
26RPS6KB21.55636950
27AURKB1.54331911
28TGFBR11.50959541
29MKNK21.45140077
30SCYL21.43102950
31CDK71.41436869
32CCNB11.41428041
33TLK11.37237090
34DYRK31.28870068
35AURKA1.27779152
36TAF11.25389462
37CHEK21.21373693
38EPHA21.17171459
39RPS6KA41.16529723
40CHEK11.15941965
41PNCK1.11917640
42PAK41.11204043
43TESK11.09032200
44CDK81.06155511
45MAP3K81.05600505
46PBK1.03819571
47CDK40.97559916
48NUAK10.97429765
49PDK40.94405212
50PDK30.94405212
51NME10.87726539
52LIMK10.86127979
53CLK10.84971413
54TNIK0.84493103
55ATM0.82833924
56ZAK0.81522800
57CSNK2A20.77973636
58BMPR1B0.77022603
59CDK20.76900554
60MAP3K120.76744635
61BRAF0.75865775
62FLT30.74226304
63STK30.73539985
64CSNK2A10.72204576
65CDK120.71889179
66EEF2K0.70558353
67SIK30.70211431
68ERBB40.67967317
69EIF2AK20.65687713
70STK100.63781556
71BRD40.63562685
72ALK0.63336163
73PAK10.62315822
74CSNK1G10.62218586
75PIM20.60331467
76CDK10.59695113
77MAP4K20.55809704
78SMG10.55006072
79PRKCI0.54849170
80STK40.54656395
81CSNK1A1L0.53832583
82TAOK20.53091197
83PKN20.51213994
84DYRK20.47451203
85MST40.47020757
86KDR0.46409876
87ERBB30.46256375
88CSNK1G20.45885708
89STK38L0.44282081
90RAF10.43271268
91PIM10.43097021
92CSNK1E0.41637947
93KSR10.41518251
94LRRK20.41378519
95MAP3K110.39800978
96MELK0.38993962
97DAPK10.38764080
98FGFR10.38029640
99CDK60.37616820
100BCKDK0.37229356
101PDK20.36282878
102MAP3K40.36272131
103PRKDC0.35493254
104MAPKAPK30.33440427
105ILK0.32723906
106CDK190.32407786
107MINK10.31932285
108CSNK1G30.31594872
109PLK20.31378087
110CDK140.31269100
111RPS6KA50.29913389
112BCR0.29688979
113AKT20.28396703
114LATS10.28390128
115MET0.28044662
116CDK11A0.27684999
117CDK180.27078976
118MAP3K100.26638023
119CDK90.25576364
120RPS6KB10.24962807
121CDK150.24639415
122WNK30.21554962
123MAP3K30.16832206

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.98906020
2Mismatch repair_Homo sapiens_hsa034304.28914392
3Proteasome_Homo sapiens_hsa030504.22523769
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.89551622
5Spliceosome_Homo sapiens_hsa030403.47056380
6RNA polymerase_Homo sapiens_hsa030203.37428473
7RNA transport_Homo sapiens_hsa030133.27822934
8Ribosome_Homo sapiens_hsa030103.24375923
9Nucleotide excision repair_Homo sapiens_hsa034203.04345121
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.00415074
11Base excision repair_Homo sapiens_hsa034102.98380907
12Homologous recombination_Homo sapiens_hsa034402.96535843
13Cell cycle_Homo sapiens_hsa041102.71406102
14One carbon pool by folate_Homo sapiens_hsa006702.53612660
15Pyrimidine metabolism_Homo sapiens_hsa002402.51836547
16Non-homologous end-joining_Homo sapiens_hsa034502.15075877
17Fanconi anemia pathway_Homo sapiens_hsa034602.08467665
18Basal transcription factors_Homo sapiens_hsa030221.99785147
19RNA degradation_Homo sapiens_hsa030181.97190309
20mRNA surveillance pathway_Homo sapiens_hsa030151.77425541
21Propanoate metabolism_Homo sapiens_hsa006401.54870839
22Purine metabolism_Homo sapiens_hsa002301.41208006
23p53 signaling pathway_Homo sapiens_hsa041151.38531350
24Epstein-Barr virus infection_Homo sapiens_hsa051691.27277376
25Steroid biosynthesis_Homo sapiens_hsa001001.25833046
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24511357
27Protein export_Homo sapiens_hsa030601.12789023
28Fatty acid elongation_Homo sapiens_hsa000621.11037417
29Oocyte meiosis_Homo sapiens_hsa041141.10740996
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04910858
31Biosynthesis of amino acids_Homo sapiens_hsa012301.03784175
32Parkinsons disease_Homo sapiens_hsa050121.00758147
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.00216245
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98665339
35Huntingtons disease_Homo sapiens_hsa050160.98060700
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96703570
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91685709
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87215898
39Oxidative phosphorylation_Homo sapiens_hsa001900.85617611
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85086652
41Systemic lupus erythematosus_Homo sapiens_hsa053220.84961488
42Antigen processing and presentation_Homo sapiens_hsa046120.81844917
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81820509
44Selenocompound metabolism_Homo sapiens_hsa004500.81807307
45Viral carcinogenesis_Homo sapiens_hsa052030.80511067
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79028123
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.75737819
48Pentose phosphate pathway_Homo sapiens_hsa000300.75530516
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74423119
50Carbon metabolism_Homo sapiens_hsa012000.71575852
51Folate biosynthesis_Homo sapiens_hsa007900.70233433
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.65961189
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62357907
54Herpes simplex infection_Homo sapiens_hsa051680.61515256
55HTLV-I infection_Homo sapiens_hsa051660.59337282
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55845977
57Legionellosis_Homo sapiens_hsa051340.53814083
58Vitamin B6 metabolism_Homo sapiens_hsa007500.51655057
59Thyroid cancer_Homo sapiens_hsa052160.51075709
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50830439
61N-Glycan biosynthesis_Homo sapiens_hsa005100.50381952
62Sulfur metabolism_Homo sapiens_hsa009200.48444875
63Fatty acid metabolism_Homo sapiens_hsa012120.47333802
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45355049
65Sulfur relay system_Homo sapiens_hsa041220.44609414
66Glutathione metabolism_Homo sapiens_hsa004800.41021122
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40747108
68Fructose and mannose metabolism_Homo sapiens_hsa000510.40501842
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37588705
70Alcoholism_Homo sapiens_hsa050340.36782694
71Lysine degradation_Homo sapiens_hsa003100.32762592
72Pyruvate metabolism_Homo sapiens_hsa006200.32144702
73MicroRNAs in cancer_Homo sapiens_hsa052060.32138400
74Hippo signaling pathway_Homo sapiens_hsa043900.31639461
75Colorectal cancer_Homo sapiens_hsa052100.30495630
76TGF-beta signaling pathway_Homo sapiens_hsa043500.30128643
77Alzheimers disease_Homo sapiens_hsa050100.29800238
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28839171
79Metabolic pathways_Homo sapiens_hsa011000.28388855
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26615932
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.26472841
82Shigellosis_Homo sapiens_hsa051310.26266973
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24756107
84Small cell lung cancer_Homo sapiens_hsa052220.24109505
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23995645
86Butanoate metabolism_Homo sapiens_hsa006500.23320663
87Galactose metabolism_Homo sapiens_hsa000520.22755819
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22587858
89Basal cell carcinoma_Homo sapiens_hsa052170.22016994
90Apoptosis_Homo sapiens_hsa042100.18849740
91HIF-1 signaling pathway_Homo sapiens_hsa040660.18411318
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18301666
93Bladder cancer_Homo sapiens_hsa052190.17938888
94Peroxisome_Homo sapiens_hsa041460.16573314
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16343891
96Adherens junction_Homo sapiens_hsa045200.15144630
97Fatty acid degradation_Homo sapiens_hsa000710.14471268
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13525047
99Renin-angiotensin system_Homo sapiens_hsa046140.13326042
100Hedgehog signaling pathway_Homo sapiens_hsa043400.12856088
101Hepatitis B_Homo sapiens_hsa051610.11269493
102Arginine biosynthesis_Homo sapiens_hsa002200.10911527
103beta-Alanine metabolism_Homo sapiens_hsa004100.10766687
104Type I diabetes mellitus_Homo sapiens_hsa049400.08237178
105Pathways in cancer_Homo sapiens_hsa052000.07616626
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07110534
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06068496
108Vibrio cholerae infection_Homo sapiens_hsa051100.05892928
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04726851
110Primary immunodeficiency_Homo sapiens_hsa053400.04636144
111Wnt signaling pathway_Homo sapiens_hsa043100.02872109
112Measles_Homo sapiens_hsa051620.02590705
113Regulation of autophagy_Homo sapiens_hsa041400.02058515
114Viral myocarditis_Homo sapiens_hsa054160.02037660
115Tyrosine metabolism_Homo sapiens_hsa003500.00425003
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532-0.0201769
117Arginine and proline metabolism_Homo sapiens_hsa00330-0.0086347
118Tight junction_Homo sapiens_hsa04530-0.0005332

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