CCT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)4.78225681
2DNA unwinding involved in DNA replication (GO:0006268)4.63042498
3DNA strand elongation involved in DNA replication (GO:0006271)4.58375629
4purine nucleobase biosynthetic process (GO:0009113)4.56819062
5formation of translation preinitiation complex (GO:0001731)4.54102109
6DNA replication initiation (GO:0006270)4.44022969
7regulation of translational fidelity (GO:0006450)4.39421622
8DNA strand elongation (GO:0022616)4.34891233
9maturation of SSU-rRNA (GO:0030490)4.23513015
10telomere maintenance via semi-conservative replication (GO:0032201)4.07513648
11IMP biosynthetic process (GO:0006188)4.07359588
12mitotic chromosome condensation (GO:0007076)4.00766021
13establishment of viral latency (GO:0019043)3.99116605
14mitotic metaphase plate congression (GO:0007080)3.95662744
15DNA replication-dependent nucleosome assembly (GO:0006335)3.91547411
16DNA replication-dependent nucleosome organization (GO:0034723)3.91547411
17DNA replication checkpoint (GO:0000076)3.90258866
18protein localization to kinetochore (GO:0034501)3.89813900
19ribosome biogenesis (GO:0042254)3.86369795
20mitotic nuclear envelope disassembly (GO:0007077)3.85479189
21cullin deneddylation (GO:0010388)3.80454896
22ribosome assembly (GO:0042255)3.79287792
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78633598
24folic acid-containing compound biosynthetic process (GO:0009396)3.77458653
25sister chromatid segregation (GO:0000819)3.74843605
26anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.74640380
27ribosomal small subunit assembly (GO:0000028)3.73313717
28spliceosomal snRNP assembly (GO:0000387)3.72138810
29proline biosynthetic process (GO:0006561)3.70035754
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.69399833
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69315635
32pore complex assembly (GO:0046931)3.66594159
33telomere maintenance via recombination (GO:0000722)3.63449960
34ribosomal large subunit biogenesis (GO:0042273)3.62275207
35nucleobase-containing small molecule interconversion (GO:0015949)3.62068917
36nuclear envelope disassembly (GO:0051081)3.60487987
37membrane disassembly (GO:0030397)3.60487987
38COPI coating of Golgi vesicle (GO:0048205)3.56058017
39Golgi transport vesicle coating (GO:0048200)3.56058017
40protein deneddylation (GO:0000338)3.55813558
41ribonucleoprotein complex biogenesis (GO:0022613)3.55306215
42mitotic recombination (GO:0006312)3.53809154
43nuclear pore organization (GO:0006999)3.53466663
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.52071876
45IMP metabolic process (GO:0046040)3.49777438
46chromatin remodeling at centromere (GO:0031055)3.49529696
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48328057
48negative regulation of ligase activity (GO:0051352)3.48328057
49proteasome assembly (GO:0043248)3.46976079
50CENP-A containing nucleosome assembly (GO:0034080)3.46627807
51peptidyl-arginine omega-N-methylation (GO:0035247)3.45016249
52metaphase plate congression (GO:0051310)3.41645842
53telomere maintenance via telomere lengthening (GO:0010833)3.39456519
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38402034
55L-serine metabolic process (GO:0006563)3.38353813
56double-strand break repair via nonhomologous end joining (GO:0006303)3.37459918
57non-recombinational repair (GO:0000726)3.37459918
58establishment of integrated proviral latency (GO:0075713)3.35689979
59histone arginine methylation (GO:0034969)3.35271674
60protein localization to chromosome, centromeric region (GO:0071459)3.35087903
61DNA deamination (GO:0045006)3.34297990
62mitotic sister chromatid segregation (GO:0000070)3.34001174
63protein complex localization (GO:0031503)3.33693520
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.30615086
65peptidyl-arginine N-methylation (GO:0035246)3.30406998
66peptidyl-arginine methylation (GO:0018216)3.30406998
67rRNA processing (GO:0006364)3.29607357
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29046856
69protein maturation by protein folding (GO:0022417)3.27589259
70regulation of mitochondrial translation (GO:0070129)3.26382085
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23377816
72viral mRNA export from host cell nucleus (GO:0046784)3.23208122
73DNA replication-independent nucleosome assembly (GO:0006336)3.21043420
74DNA replication-independent nucleosome organization (GO:0034724)3.21043420
75regulation of translational termination (GO:0006449)3.20776757
76DNA ligation (GO:0006266)3.20692236
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19711639
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19711639
79cell cycle G1/S phase transition (GO:0044843)3.19631893
80G1/S transition of mitotic cell cycle (GO:0000082)3.19631893
81translational initiation (GO:0006413)3.18707039
82rRNA metabolic process (GO:0016072)3.18565807
83DNA topological change (GO:0006265)3.18365628
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18143975
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18143975
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18143975
87signal transduction involved in DNA integrity checkpoint (GO:0072401)3.18044063
88signal transduction involved in DNA damage checkpoint (GO:0072422)3.18044063
89histone H2A acetylation (GO:0043968)3.17699329
90spliceosomal tri-snRNP complex assembly (GO:0000244)3.17240914
91somatic hypermutation of immunoglobulin genes (GO:0016446)3.16355857
92somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16355857
93signal transduction involved in cell cycle checkpoint (GO:0072395)3.14386627
94transcription-coupled nucleotide-excision repair (GO:0006283)3.14182768
95tRNA aminoacylation for protein translation (GO:0006418)3.13178050
96DNA geometric change (GO:0032392)3.12489344
97negative regulation of chromosome segregation (GO:0051985)3.12401553
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.12307746
99negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12307746
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12307746
101negative regulation of sister chromatid segregation (GO:0033046)3.12307746
102nuclear pore complex assembly (GO:0051292)3.11569028
103postreplication repair (GO:0006301)3.10789225
104spliceosomal complex assembly (GO:0000245)3.10608226
105positive regulation of ligase activity (GO:0051351)3.10607136
106negative regulation of mRNA processing (GO:0050686)3.09463695
107translational termination (GO:0006415)3.09255038
108rRNA modification (GO:0000154)3.08918925
109establishment of chromosome localization (GO:0051303)3.08844230
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08752387
111viral transcription (GO:0019083)3.08025316
112regulation of spindle organization (GO:0090224)3.08015114
113histone exchange (GO:0043486)3.07865045
114amino acid activation (GO:0043038)3.07743101
115tRNA aminoacylation (GO:0043039)3.07743101
116translational elongation (GO:0006414)3.06174409
117mitotic spindle assembly checkpoint (GO:0007094)3.05687010
118regulation of cellular amino acid metabolic process (GO:0006521)3.03904173
119spindle assembly checkpoint (GO:0071173)3.03298667
120attachment of spindle microtubules to kinetochore (GO:0008608)3.03009825
121kinetochore organization (GO:0051383)3.02703706
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01762694
123regulation of ubiquitin-protein transferase activity (GO:0051438)3.01347771
124DNA duplex unwinding (GO:0032508)3.01268283
125regulation of centrosome cycle (GO:0046605)3.00966739
126heterochromatin organization (GO:0070828)2.97318448
127mitotic sister chromatid cohesion (GO:0007064)2.96340469
128regulation of mitotic spindle organization (GO:0060236)2.95878650
129regulation of translational elongation (GO:0006448)2.90079224
130negative regulation of mRNA metabolic process (GO:1903312)2.89875077
131cellular protein complex localization (GO:0034629)2.88299553
132regulation of chromosome segregation (GO:0051983)2.86162439
133spindle checkpoint (GO:0031577)2.82887818
134rRNA transcription (GO:0009303)2.82440796
135pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82051301
136DNA conformation change (GO:0071103)2.81574795
137mitotic spindle checkpoint (GO:0071174)2.81496184
138negative regulation of RNA splicing (GO:0033119)2.81477227
139pteridine-containing compound biosynthetic process (GO:0042559)2.81468074
140positive regulation of chromosome segregation (GO:0051984)2.80124580
141base-excision repair (GO:0006284)2.79117196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.75118160
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.57276765
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91252656
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.51108560
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46478538
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42369921
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.25986179
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.21530306
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20249679
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.10611061
11* GABP_17652178_ChIP-ChIP_JURKAT_Human3.09355339
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05954951
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02638304
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91607594
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88681722
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83595443
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83387271
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.57695262
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52672664
20* XRN2_22483619_ChIP-Seq_HELA_Human2.52232272
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47477126
22* VDR_23849224_ChIP-Seq_CD4+_Human2.27764407
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19886646
24* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14810516
25DCP1A_22483619_ChIP-Seq_HELA_Human2.13963875
26GABP_19822575_ChIP-Seq_HepG2_Human2.06571126
27AR_21909140_ChIP-Seq_LNCAP_Human2.05102913
28FOXP3_21729870_ChIP-Seq_TREG_Human2.04477252
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04167716
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02716580
31MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02127023
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01908847
33* TTF2_22483619_ChIP-Seq_HELA_Human1.98521416
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93777255
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.87012376
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85612412
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85337205
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84013826
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82323109
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81749130
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.80291545
42ZNF263_19887448_ChIP-Seq_K562_Human1.70836547
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70574717
44CIITA_25753668_ChIP-Seq_RAJI_Human1.67238484
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66975843
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65257983
47ELK1_19687146_ChIP-ChIP_HELA_Human1.64653429
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61617167
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60136960
50* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56815749
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55900446
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.51527037
53KDM5A_27292631_Chip-Seq_BREAST_Human1.48355645
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43535656
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43192628
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42649927
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39333030
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.39209096
59* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38723020
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38047004
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36829951
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35999433
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35323670
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34168273
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31564967
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28588874
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28081634
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24681102
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21817283
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19172156
71TFEB_21752829_ChIP-Seq_HELA_Human1.18656933
72MYC_22102868_ChIP-Seq_BL_Human1.18278369
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16970598
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14918471
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14787051
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11979059
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08675999
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08395045
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07249103
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06643562
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05904802
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05285084
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04723971
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03929392
85* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02349261
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01882142
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.00206959
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98063125
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97404685
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97055772
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96396783
92CLOCK_20551151_ChIP-Seq_293T_Human0.95867849
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.95600275
94MYC_18940864_ChIP-ChIP_HL60_Human0.95482337
95* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95443640
96TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94142848
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.94051578
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93944111
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92334644
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92177092
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90530311
102* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90436627
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89113542
104OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87852084
105CHD1_26751641_Chip-Seq_LNCaP_Human0.87694706
106* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87591491
107* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87254328
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84937840
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84745609
110TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84286401
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81677749
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81005746
113* SOX17_20123909_ChIP-Seq_XEN_Mouse0.80503671
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77844427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.49482494
2MP0010094_abnormal_chromosome_stability4.78826903
3MP0004957_abnormal_blastocyst_morpholog4.78164816
4MP0003111_abnormal_nucleus_morphology4.64656466
5MP0003077_abnormal_cell_cycle4.07994187
6MP0008058_abnormal_DNA_repair3.60526758
7MP0008057_abnormal_DNA_replication3.56161361
8MP0003123_paternal_imprinting3.24058554
9MP0008007_abnormal_cellular_replicative3.06804543
10MP0008932_abnormal_embryonic_tissue3.02163952
11MP0008877_abnormal_DNA_methylation2.97022285
12MP0001730_embryonic_growth_arrest2.64315906
13MP0000350_abnormal_cell_proliferation2.27722601
14MP0003786_premature_aging2.21668048
15MP0010352_gastrointestinal_tract_polyps2.03292750
16MP0002653_abnormal_ependyma_morphology2.02338754
17MP0002877_abnormal_melanocyte_morpholog1.98537601
18MP0009697_abnormal_copulation1.97574801
19MP0001697_abnormal_embryo_size1.89144066
20MP0003121_genomic_imprinting1.84341989
21MP0001672_abnormal_embryogenesis/_devel1.83001811
22MP0005380_embryogenesis_phenotype1.83001811
23MP0010030_abnormal_orbit_morphology1.81078384
24MP0002080_prenatal_lethality1.77902179
25MP0002085_abnormal_embryonic_tissue1.69863834
26MP0003984_embryonic_growth_retardation1.65043616
27MP0002084_abnormal_developmental_patter1.64098767
28MP0003806_abnormal_nucleotide_metabolis1.63667657
29MP0000537_abnormal_urethra_morphology1.62805020
30MP0003718_maternal_effect1.62643718
31MP0002088_abnormal_embryonic_growth/wei1.60837976
32MP0010307_abnormal_tumor_latency1.53056937
33MP0001661_extended_life_span1.52038012
34MP0010234_abnormal_vibrissa_follicle1.51886273
35MP0003315_abnormal_perineum_morphology1.51825509
36MP0002210_abnormal_sex_determination1.51609765
37MP0004197_abnormal_fetal_growth/weight/1.49039520
38MP0000313_abnormal_cell_death1.42813511
39MP0005451_abnormal_body_composition1.41228895
40MP0002160_abnormal_reproductive_system1.39356832
41MP0002396_abnormal_hematopoietic_system1.38750217
42MP0004133_heterotaxia1.37992886
43MP0003890_abnormal_embryonic-extraembry1.35750865
44MP0003567_abnormal_fetal_cardiomyocyte1.34649882
45MP0002086_abnormal_extraembryonic_tissu1.33398587
46MP0001293_anophthalmia1.33101222
47MP0001145_abnormal_male_reproductive1.32849189
48MP0003119_abnormal_digestive_system1.32723334
49MP0005501_abnormal_skin_physiology1.31765045
50MP0003705_abnormal_hypodermis_morpholog1.28718106
51MP0001929_abnormal_gametogenesis1.27088566
52MP0000358_abnormal_cell_content/1.25299670
53MP0000490_abnormal_crypts_of1.24959258
54MP0002019_abnormal_tumor_incidence1.13374847
55MP0004185_abnormal_adipocyte_glucose1.10847073
56MP0000653_abnormal_sex_gland1.09052121
57MP0003566_abnormal_cell_adhesion1.08351303
58MP0003122_maternal_imprinting1.05255103
59MP0005623_abnormal_meninges_morphology1.04505497
60MP0004808_abnormal_hematopoietic_stem1.03641011
61MP0002796_impaired_skin_barrier1.02669687
62MP0009053_abnormal_anal_canal1.01712586
63MP0003941_abnormal_skin_development0.99422440
64MP0000678_abnormal_parathyroid_gland0.98786015
65MP0003385_abnormal_body_wall0.97961211
66MP0005389_reproductive_system_phenotype0.97269934
67MP0009672_abnormal_birth_weight0.92646844
68MP0002111_abnormal_tail_morphology0.92161259
69MP0003698_abnormal_male_reproductive0.91677028
70MP0004233_abnormal_muscle_weight0.91249767
71MP0003221_abnormal_cardiomyocyte_apopto0.90816909
72MP0005384_cellular_phenotype0.89580311
73MP0009333_abnormal_splenocyte_physiolog0.88304489
74MP0006035_abnormal_mitochondrial_morpho0.88147196
75MP0002751_abnormal_autonomic_nervous0.87016186
76MP0004272_abnormal_basement_membrane0.86728888
77MP0008789_abnormal_olfactory_epithelium0.85273888
78MP0001346_abnormal_lacrimal_gland0.82751151
79MP0005330_cardiomyopathy0.82391838
80MP0001915_intracranial_hemorrhage0.81530948
81MP0006292_abnormal_olfactory_placode0.81523158
82MP0000762_abnormal_tongue_morphology0.79529026
83MP0002938_white_spotting0.78474306
84MP0003937_abnormal_limbs/digits/tail_de0.77423301
85MP0000747_muscle_weakness0.76430837
86MP0005076_abnormal_cell_differentiation0.74926283
87MP0003942_abnormal_urinary_system0.73816214
88MP0001529_abnormal_vocalization0.73022978
89MP0005621_abnormal_cell_physiology0.72856350
90MP0002060_abnormal_skin_morphology0.71966862
91MP0006054_spinal_hemorrhage0.71095582
92MP0006036_abnormal_mitochondrial_physio0.71026449
93MP0003861_abnormal_nervous_system0.70570321
94MP0001881_abnormal_mammary_gland0.69727506
95MP0002161_abnormal_fertility/fecundity0.69252592
96MP0002163_abnormal_gland_morphology0.68720083
97MP0001286_abnormal_eye_development0.66850313
98MP0009703_decreased_birth_body0.66745397
99MP0000703_abnormal_thymus_morphology0.66506041
100MP0000579_abnormal_nail_morphology0.65464241
101MP0001119_abnormal_female_reproductive0.65382342
102MP0002233_abnormal_nose_morphology0.64266734
103MP0001919_abnormal_reproductive_system0.63421241
104MP0005257_abnormal_intraocular_pressure0.63196331
105MP0000049_abnormal_middle_ear0.61812124
106MP0000428_abnormal_craniofacial_morphol0.61552535
107MP0002102_abnormal_ear_morphology0.60886388
108MP0003115_abnormal_respiratory_system0.60598561
109MP0005410_abnormal_fertilization0.60183297
110MP0005377_hearing/vestibular/ear_phenot0.59859048
111MP0003878_abnormal_ear_physiology0.59859048
112MP0003186_abnormal_redox_activity0.59849802
113MP0010630_abnormal_cardiac_muscle0.59820577
114MP0002269_muscular_atrophy0.59784147
115MP0008260_abnormal_autophagy0.59497299
116MP0002132_abnormal_respiratory_system0.58722455
117MP0004264_abnormal_extraembryonic_tissu0.57669240
118MP0002114_abnormal_axial_skeleton0.57495655
119MP0000751_myopathy0.57489421
120MP0001727_abnormal_embryo_implantation0.57426532
121MP0002697_abnormal_eye_size0.57170068
122MP0003283_abnormal_digestive_organ0.57118945
123MP0001545_abnormal_hematopoietic_system0.57043786
124MP0005397_hematopoietic_system_phenotyp0.57043786
125MP0001849_ear_inflammation0.56123105
126MP0005394_taste/olfaction_phenotype0.55959524
127MP0005499_abnormal_olfactory_system0.55959524
128MP0005266_abnormal_metabolism0.55682737
129MP0002092_abnormal_eye_morphology0.55266298

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.99289513
2Breast hypoplasia (HP:0003187)3.87713018
3Degeneration of anterior horn cells (HP:0002398)3.82381560
4Abnormality of the anterior horn cell (HP:0006802)3.82381560
5Cerebral hypomyelination (HP:0006808)3.75686160
6Oral leukoplakia (HP:0002745)3.56628097
7Reticulocytopenia (HP:0001896)3.55026940
8Ependymoma (HP:0002888)3.54537728
9Colon cancer (HP:0003003)3.46091091
10Selective tooth agenesis (HP:0001592)3.45188737
11Abnormality of cells of the erythroid lineage (HP:0012130)3.36243272
12Patellar aplasia (HP:0006443)3.35329287
13Cholecystitis (HP:0001082)3.32503875
14Abnormal gallbladder physiology (HP:0012438)3.32503875
15Abnormality of the labia minora (HP:0012880)3.30918421
16Progressive muscle weakness (HP:0003323)3.29344120
17Carpal bone hypoplasia (HP:0001498)3.28243898
18Abnormal number of erythroid precursors (HP:0012131)3.22350229
19Medulloblastoma (HP:0002885)3.19945815
20Aplasia/Hypoplasia of the patella (HP:0006498)3.19626503
21Rough bone trabeculation (HP:0100670)3.15881411
22Abnormality of glycolysis (HP:0004366)2.96005374
23Increased serum pyruvate (HP:0003542)2.96005374
24Aplastic anemia (HP:0001915)2.94520968
25Increased nuchal translucency (HP:0010880)2.85963927
2611 pairs of ribs (HP:0000878)2.82704079
27Agnosia (HP:0010524)2.76991889
28Meckel diverticulum (HP:0002245)2.74431853
29Chromsome breakage (HP:0040012)2.73239075
30Absent thumb (HP:0009777)2.67895049
31Ragged-red muscle fibers (HP:0003200)2.65878297
32Impulsivity (HP:0100710)2.65204936
33Abnormality of the ileum (HP:0001549)2.63339999
34Neoplasm of the pancreas (HP:0002894)2.63140637
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61743280
36Abnormality of the preputium (HP:0100587)2.61499812
37Hypoplasia of the capital femoral epiphysis (HP:0003090)2.60823152
38Absent radius (HP:0003974)2.55814891
39Premature graying of hair (HP:0002216)2.54837328
40Spastic diplegia (HP:0001264)2.52748236
41Trismus (HP:0000211)2.52318445
42Atrophy/Degeneration involving motor neurons (HP:0007373)2.48816416
43Horseshoe kidney (HP:0000085)2.45980892
44Progressive external ophthalmoplegia (HP:0000590)2.45254375
45Abnormality of the umbilical cord (HP:0010881)2.44516554
46Abnormality of chromosome stability (HP:0003220)2.44081532
47Facial cleft (HP:0002006)2.42776239
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.40125936
49Insomnia (HP:0100785)2.40049828
50Cortical dysplasia (HP:0002539)2.38700568
51Absent forearm bone (HP:0003953)2.37068938
52Aplasia involving forearm bones (HP:0009822)2.37068938
53Rhabdomyosarcoma (HP:0002859)2.35404121
54Macrocytic anemia (HP:0001972)2.34788805
55Supernumerary spleens (HP:0009799)2.33636946
56Small intestinal stenosis (HP:0012848)2.31986330
57Duodenal stenosis (HP:0100867)2.31986330
58Abnormal lung lobation (HP:0002101)2.30780889
59CNS hypomyelination (HP:0003429)2.28448494
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26073229
61Abnormal number of incisors (HP:0011064)2.24865287
62Microretrognathia (HP:0000308)2.24196248
63Missing ribs (HP:0000921)2.23721874
64Abnormal trabecular bone morphology (HP:0100671)2.22673718
65Hyperacusis (HP:0010780)2.21203567
66Shoulder girdle muscle weakness (HP:0003547)2.20525487
67Astrocytoma (HP:0009592)2.20157036
68Abnormality of the astrocytes (HP:0100707)2.20157036
69Postnatal microcephaly (HP:0005484)2.18344859
70Sloping forehead (HP:0000340)2.18316784
71Bone marrow hypocellularity (HP:0005528)2.18230252
72Premature ovarian failure (HP:0008209)2.16969726
73Cellular immunodeficiency (HP:0005374)2.12683238
74Myelodysplasia (HP:0002863)2.12466970
75Hypoplasia of the pons (HP:0012110)2.11483996
76Pallor (HP:0000980)2.10933671
77Increased serum lactate (HP:0002151)2.09124818
78Glioma (HP:0009733)2.07738798
79Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07360437
80Secondary amenorrhea (HP:0000869)2.06479372
81Abnormalities of placenta or umbilical cord (HP:0001194)2.06190336
82Nephroblastoma (Wilms tumor) (HP:0002667)2.04732743
83Slender long bone (HP:0003100)2.03958975
84Atresia of the external auditory canal (HP:0000413)2.03627012
85Abnormal umbilical cord blood vessels (HP:0011403)2.02329753
86Single umbilical artery (HP:0001195)2.02329753
87Abnormality of the fetal cardiovascular system (HP:0010948)2.02329753
88Glossoptosis (HP:0000162)2.01726079
89Basal cell carcinoma (HP:0002671)2.00726396
90Abdominal situs inversus (HP:0003363)2.00105006
91Abnormality of abdominal situs (HP:0011620)2.00105006
92Neoplasm of the colon (HP:0100273)1.99336936
93Overlapping toe (HP:0001845)1.99105432
94Angiofibromas (HP:0010615)1.98776932
95Adenoma sebaceum (HP:0009720)1.98776932
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.98679248
97Pelvic girdle muscle weakness (HP:0003749)1.98497893
98Proximal placement of thumb (HP:0009623)1.97363820
99Orthostatic hypotension (HP:0001278)1.97335456
100Absent epiphyses (HP:0010577)1.96630626
101Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96630626
102Type I transferrin isoform profile (HP:0003642)1.95333984
103Multiple enchondromatosis (HP:0005701)1.94491287
104Tracheoesophageal fistula (HP:0002575)1.93056780
105Abnormality of the duodenum (HP:0002246)1.92859645
106Overriding aorta (HP:0002623)1.91959980
107Unsteady gait (HP:0002317)1.89794072
108Deviation of the thumb (HP:0009603)1.89792210
109Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88935885
110Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88935885
111Megaloblastic anemia (HP:0001889)1.88361121
112Embryonal renal neoplasm (HP:0011794)1.87723175
113Tongue fasciculations (HP:0001308)1.86224660
114Entropion (HP:0000621)1.85346720
115Triphalangeal thumb (HP:0001199)1.85016325
116Increased CSF lactate (HP:0002490)1.84881388
117Abnormality of the pons (HP:0007361)1.83861646
118Abnormality of reticulocytes (HP:0004312)1.83453153
119High anterior hairline (HP:0009890)1.82695017
120Cleft eyelid (HP:0000625)1.82224431
121Gout (HP:0001997)1.81600579
122Squamous cell carcinoma (HP:0002860)1.80901820
123Ovarian neoplasm (HP:0100615)1.80481434
124Microvesicular hepatic steatosis (HP:0001414)1.79898203
125Freckling (HP:0001480)1.79835346
126Abnormality of methionine metabolism (HP:0010901)1.78820295
127Breech presentation (HP:0001623)1.78489367
128Microglossia (HP:0000171)1.78464261
129Abnormality of cochlea (HP:0000375)1.77181970
130Abnormal mitochondria in muscle tissue (HP:0008316)1.73158222
131Abnormality of pain sensation (HP:0010832)1.72775102
132Impaired pain sensation (HP:0007328)1.72775102
133Cholelithiasis (HP:0001081)1.71185481
134Testicular atrophy (HP:0000029)1.70515609
135Choanal atresia (HP:0000453)1.69406490
136Reduced antithrombin III activity (HP:0001976)1.68439830
137Abnormality of the calcaneus (HP:0008364)1.67585384
138Broad distal phalanx of finger (HP:0009836)1.67216675
139Poikiloderma (HP:0001029)1.66076555
140Abnormal protein glycosylation (HP:0012346)1.65940753
141Abnormal glycosylation (HP:0012345)1.65940753
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65940753
143Abnormal protein N-linked glycosylation (HP:0012347)1.65940753
144Asymmetry of the thorax (HP:0001555)1.64454924
145Abnormality of the carotid arteries (HP:0005344)1.63264145
146Upper limb muscle weakness (HP:0003484)1.62816754
147Exercise intolerance (HP:0003546)1.62757590
148Septate vagina (HP:0001153)1.62640920
149Acute encephalopathy (HP:0006846)1.61261386
150Prominent metopic ridge (HP:0005487)1.60260399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.11732550
2WEE14.39861197
3CDC73.82346523
4TSSK63.81501255
5EIF2AK13.46803038
6NEK12.79754829
7VRK22.79517744
8SMG12.77859908
9NEK22.40608836
10SRPK12.39536606
11STK162.33826090
12PASK2.23994501
13TTK2.12976188
14BRSK22.06932545
15TESK22.00353253
16PLK11.97626258
17CCNB11.95650514
18PLK41.93795974
19PLK31.92172486
20EIF2AK31.90662971
21ACVR1B1.86753877
22EPHA21.81116834
23TLK11.78687984
24TESK11.69157495
25MKNK11.65051269
26ATR1.57985068
27VRK11.57131277
28PDK41.55463145
29PDK31.55463145
30BRSK11.53285202
31RPS6KB21.51733029
32AURKA1.50295493
33AURKB1.48175561
34PNCK1.47256139
35NME21.42048192
36CDK71.39708766
37ICK1.37748910
38IRAK31.33444581
39PAK41.27806336
40CHEK21.26667772
41TRIB31.25403677
42MST1R1.23991414
43DYRK31.23745513
44TGFBR11.22555921
45CHEK11.14616604
46SCYL21.13741620
47EEF2K1.11953773
48MAP3K81.10243569
49RPS6KA41.05628056
50BRAF1.02386065
51TRIM281.01010641
52MKNK21.00349036
53MST41.00044655
54ZAK0.99452149
55LIMK10.98638172
56TAF10.95960548
57CLK10.90788312
58CDK40.87467232
59NME10.85262570
60PAK10.80186998
61PDK20.79810988
62CSNK1G30.77912258
63CDK80.76425975
64CDK20.75841047
65ATM0.74150187
66ERBB40.73777125
67CSNK2A20.72859010
68AKT30.72144545
69STK38L0.70091339
70PRKCI0.68931740
71CSNK2A10.67508251
72ARAF0.64400179
73CSNK1A1L0.63768912
74CDK10.59688448
75ALK0.59274845
76MET0.58940237
77CSNK1G10.58893104
78STK100.58685577
79BCKDK0.58569928
80DYRK20.57687663
81BRD40.56344030
82DAPK10.55779702
83MAPKAPK30.55334255
84PIM20.55201350
85CDK60.53319426
86MAP3K110.49957760
87FGFR40.49655700
88CDK90.49185701
89EIF2AK20.47562219
90RAF10.47280533
91TAOK20.46640512
92KDR0.46403556
93CDK120.45776013
94LATS20.45204022
95MAP3K120.45158274
96MAP3K100.44758448
97CSNK1E0.44292753
98STK40.43535310
99TTN0.40831597
100ILK0.39350481
101PIM10.39192596
102PKN20.37930462
103MAPKAPK50.35967231
104CSNK1G20.34668017
105PBK0.34438243
106ERBB30.34403889
107AKT20.33284016
108LRRK20.32708551
109PRKDC0.31011577
110FGFR10.30800665
111CDK180.30748194
112FLT30.30319768
113CDK140.30053171
114CDK11A0.29679410
115RPS6KA50.29089963
116CDK150.27970503
117MAP2K30.26599246
118RPS6KB10.25812849
119WNK30.25566301
120MTOR0.23624932
121BCR0.23098452
122MELK0.22173296
123PLK20.21397137
124DAPK30.15694709

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69422156
2Proteasome_Homo sapiens_hsa030504.30023161
3Mismatch repair_Homo sapiens_hsa034304.15857859
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.75914833
5Spliceosome_Homo sapiens_hsa030403.39212950
6RNA transport_Homo sapiens_hsa030133.32254923
7RNA polymerase_Homo sapiens_hsa030203.28701075
8Ribosome_Homo sapiens_hsa030103.15221455
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.14915326
10Base excision repair_Homo sapiens_hsa034102.97321856
11Nucleotide excision repair_Homo sapiens_hsa034202.90993018
12Homologous recombination_Homo sapiens_hsa034402.81665705
13Cell cycle_Homo sapiens_hsa041102.65281540
14One carbon pool by folate_Homo sapiens_hsa006702.56819745
15Pyrimidine metabolism_Homo sapiens_hsa002402.42426941
16Basal transcription factors_Homo sapiens_hsa030221.98696620
17Fanconi anemia pathway_Homo sapiens_hsa034601.98353643
18Non-homologous end-joining_Homo sapiens_hsa034501.97910411
19RNA degradation_Homo sapiens_hsa030181.81796045
20mRNA surveillance pathway_Homo sapiens_hsa030151.79257747
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56907850
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52799452
23p53 signaling pathway_Homo sapiens_hsa041151.41368243
24Purine metabolism_Homo sapiens_hsa002301.39101247
25Fatty acid elongation_Homo sapiens_hsa000621.34518594
26Epstein-Barr virus infection_Homo sapiens_hsa051691.28174780
27Oocyte meiosis_Homo sapiens_hsa041141.21662926
28Biosynthesis of amino acids_Homo sapiens_hsa012301.14281291
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.14079901
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11442493
31Steroid biosynthesis_Homo sapiens_hsa001001.09155473
32Huntingtons disease_Homo sapiens_hsa050161.08492564
33Parkinsons disease_Homo sapiens_hsa050121.02967936
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99509248
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96514832
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96149954
37Protein export_Homo sapiens_hsa030600.94713595
38Oxidative phosphorylation_Homo sapiens_hsa001900.88598094
39Pentose phosphate pathway_Homo sapiens_hsa000300.87376786
40Carbon metabolism_Homo sapiens_hsa012000.87134848
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85158181
42Selenocompound metabolism_Homo sapiens_hsa004500.83950959
43Systemic lupus erythematosus_Homo sapiens_hsa053220.83806032
44Viral carcinogenesis_Homo sapiens_hsa052030.83387967
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83337653
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81288881
47Antigen processing and presentation_Homo sapiens_hsa046120.76592815
48Fructose and mannose metabolism_Homo sapiens_hsa000510.74244645
49Vitamin B6 metabolism_Homo sapiens_hsa007500.74171012
50Propanoate metabolism_Homo sapiens_hsa006400.72484905
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.71303753
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70590676
53Folate biosynthesis_Homo sapiens_hsa007900.64411467
54Fatty acid metabolism_Homo sapiens_hsa012120.61916786
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61856351
56HTLV-I infection_Homo sapiens_hsa051660.60126996
57Arginine biosynthesis_Homo sapiens_hsa002200.60028390
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57755255
59N-Glycan biosynthesis_Homo sapiens_hsa005100.54146918
60Thyroid cancer_Homo sapiens_hsa052160.53467111
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.53368000
62Legionellosis_Homo sapiens_hsa051340.52987090
63Sulfur relay system_Homo sapiens_hsa041220.51521120
64Lysine degradation_Homo sapiens_hsa003100.49564867
65Herpes simplex infection_Homo sapiens_hsa051680.48540274
66Pyruvate metabolism_Homo sapiens_hsa006200.48409866
67Glutathione metabolism_Homo sapiens_hsa004800.47058445
68Hippo signaling pathway_Homo sapiens_hsa043900.45098215
69Alcoholism_Homo sapiens_hsa050340.44838265
70Galactose metabolism_Homo sapiens_hsa000520.43702202
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40031425
72Adherens junction_Homo sapiens_hsa045200.35281091
73Chronic myeloid leukemia_Homo sapiens_hsa052200.34829113
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.34392724
75Basal cell carcinoma_Homo sapiens_hsa052170.34373639
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33798286
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32385915
78Bladder cancer_Homo sapiens_hsa052190.31153356
79Alzheimers disease_Homo sapiens_hsa050100.30457221
80MicroRNAs in cancer_Homo sapiens_hsa052060.29762943
81HIF-1 signaling pathway_Homo sapiens_hsa040660.29414710
82Hedgehog signaling pathway_Homo sapiens_hsa043400.28719458
83Colorectal cancer_Homo sapiens_hsa052100.28630396
84Phenylalanine metabolism_Homo sapiens_hsa003600.28352611
85Metabolic pathways_Homo sapiens_hsa011000.28237613
86Small cell lung cancer_Homo sapiens_hsa052220.26624102
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26590344
88Regulation of autophagy_Homo sapiens_hsa041400.26015901
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25617734
90Vibrio cholerae infection_Homo sapiens_hsa051100.24848881
91TGF-beta signaling pathway_Homo sapiens_hsa043500.24426069
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22265112
93Sulfur metabolism_Homo sapiens_hsa009200.22072746
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21401839
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18770381
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18625464
97Apoptosis_Homo sapiens_hsa042100.18392450
98Pancreatic cancer_Homo sapiens_hsa052120.18269103
99Shigellosis_Homo sapiens_hsa051310.16779719
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15761822
101Tight junction_Homo sapiens_hsa045300.14682369
102Notch signaling pathway_Homo sapiens_hsa043300.14384377
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14143710
104Non-small cell lung cancer_Homo sapiens_hsa052230.13810076
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.11093462
106Renin-angiotensin system_Homo sapiens_hsa046140.10909147
107Pathways in cancer_Homo sapiens_hsa052000.09923544
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09406493
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09363625
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07788748
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.06492926
112Type I diabetes mellitus_Homo sapiens_hsa049400.05954000
113Wnt signaling pathway_Homo sapiens_hsa043100.05499015
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.04964705
115Melanoma_Homo sapiens_hsa052180.04406434
116mTOR signaling pathway_Homo sapiens_hsa041500.04055797
117Hepatitis B_Homo sapiens_hsa051610.03359861
118Arginine and proline metabolism_Homo sapiens_hsa003300.01029269

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