CCT6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.92049848
2piRNA metabolic process (GO:0034587)9.55175179
3epithelial cilium movement (GO:0003351)9.41139511
4motile cilium assembly (GO:0044458)9.27426890
5reproduction (GO:0000003)9.06990638
6spermatid development (GO:0007286)9.05438391
7male meiosis (GO:0007140)8.54532482
8cilium movement (GO:0003341)8.12181430
9synaptonemal complex organization (GO:0070193)8.01113828
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.97829614
11regulation of cilium movement (GO:0003352)7.75083866
12synaptonemal complex assembly (GO:0007130)7.71973637
13single fertilization (GO:0007338)7.26780713
14sperm capacitation (GO:0048240)6.55489009
15fertilization (GO:0009566)6.23108923
16DNA methylation involved in gamete generation (GO:0043046)6.14218579
17negative regulation of inclusion body assembly (GO:0090084)6.08454577
18male meiosis I (GO:0007141)5.89966667
19* spermatogenesis (GO:0007283)5.86621109
20* male gamete generation (GO:0048232)5.84739435
21behavioral response to nicotine (GO:0035095)5.78592650
22microtubule depolymerization (GO:0007019)5.63066378
23chromosome organization involved in meiosis (GO:0070192)5.54147653
24* gamete generation (GO:0007276)5.37739390
25organic cation transport (GO:0015695)5.30536157
26meiotic nuclear division (GO:0007126)5.18852465
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.15946822
28germ cell development (GO:0007281)5.15677027
29ventricular system development (GO:0021591)5.10835900
30regulation of inclusion body assembly (GO:0090083)5.08474334
31meiosis I (GO:0007127)4.87383103
32seminiferous tubule development (GO:0072520)4.78269530
33calcium ion-dependent exocytosis (GO:0017156)4.65999088
34microtubule severing (GO:0051013)4.63079601
35cell recognition (GO:0008037)4.61972573
36regulation of microtubule-based movement (GO:0060632)4.52009062
37meiotic cell cycle (GO:0051321)4.36582745
38spermatid nucleus differentiation (GO:0007289)4.34028591
39* multicellular organismal reproductive process (GO:0048609)4.20551782
40left/right pattern formation (GO:0060972)4.03645255
41protein localization to cilium (GO:0061512)3.95582367
42monoubiquitinated protein deubiquitination (GO:0035520)3.89753200
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.84211202
44serotonin metabolic process (GO:0042428)3.76687034
45positive regulation of gastrulation (GO:2000543)3.70876047
46glycerol ether metabolic process (GO:0006662)3.66345668
47nonmotile primary cilium assembly (GO:0035058)3.65738440
48adaptation of signaling pathway (GO:0023058)3.64817438
49chromosome condensation (GO:0030261)3.63847692
50primary amino compound metabolic process (GO:1901160)3.59379035
51genitalia morphogenesis (GO:0035112)3.58867039
52neuronal action potential (GO:0019228)3.54671899
53DNA packaging (GO:0006323)3.54061134
54gene silencing by RNA (GO:0031047)3.53422414
55synapsis (GO:0007129)3.47332700
56meiotic cell cycle process (GO:1903046)3.45408159
57intraciliary transport (GO:0042073)3.43674927
58protein polyglutamylation (GO:0018095)3.40464706
59L-fucose catabolic process (GO:0042355)3.40453089
60fucose catabolic process (GO:0019317)3.40453089
61L-fucose metabolic process (GO:0042354)3.40453089
62multicellular organismal development (GO:0007275)3.39334275
63ether metabolic process (GO:0018904)3.37321720
64regulation of centriole replication (GO:0046599)3.31762096
65axoneme assembly (GO:0035082)3.31624939
66regulation of spindle checkpoint (GO:0090231)3.25227114
67nephron tubule morphogenesis (GO:0072078)3.22502720
68nephron epithelium morphogenesis (GO:0072088)3.22502720
69alditol metabolic process (GO:0019400)3.20429311
70dopamine transport (GO:0015872)3.17835356
71carnitine transport (GO:0015879)3.16838700
72amino-acid betaine transport (GO:0015838)3.16838700
73centriole assembly (GO:0098534)3.15489608
74cellular ketone body metabolic process (GO:0046950)3.12174201
75interferon-gamma secretion (GO:0072643)3.11731883
76centriole replication (GO:0007099)3.11133941
77carnitine transmembrane transport (GO:1902603)3.09886497
78nucleoside diphosphate phosphorylation (GO:0006165)3.07514525
79microtubule-based movement (GO:0007018)3.05954828
80synaptic transmission, cholinergic (GO:0007271)3.05312992
81detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02039017
82polyol catabolic process (GO:0046174)3.01101332
83protein refolding (GO:0042026)3.00664561
84somite rostral/caudal axis specification (GO:0032525)3.00421944
85single strand break repair (GO:0000012)3.00313451
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00125340
87tachykinin receptor signaling pathway (GO:0007217)2.99848114
88negative regulation of organelle assembly (GO:1902116)2.98279604
89indolalkylamine metabolic process (GO:0006586)2.98196665
90microtubule polymerization or depolymerization (GO:0031109)2.97775199
91protein K11-linked deubiquitination (GO:0035871)2.97601785
92indole-containing compound metabolic process (GO:0042430)2.97051773
93dopamine biosynthetic process (GO:0042416)2.96848387
94regulation of meiosis I (GO:0060631)2.96764617
95cilium organization (GO:0044782)2.96314845
96nuclear pore complex assembly (GO:0051292)2.95382860
97response to pheromone (GO:0019236)2.95134552
98kidney morphogenesis (GO:0060993)2.94508715
99spinal cord motor neuron differentiation (GO:0021522)2.93496591
100gamma-aminobutyric acid transport (GO:0015812)2.93375559
101mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89084721
102mitochondrial respiratory chain complex I assembly (GO:0032981)2.89084721
103NADH dehydrogenase complex assembly (GO:0010257)2.89084721
104nucleus organization (GO:0006997)2.87453896
105regulation of glucokinase activity (GO:0033131)2.85505495
106regulation of hexokinase activity (GO:1903299)2.85505495
107GTP biosynthetic process (GO:0006183)2.84990601
108detection of light stimulus involved in visual perception (GO:0050908)2.82826394
109detection of light stimulus involved in sensory perception (GO:0050962)2.82826394
110photoreceptor cell maintenance (GO:0045494)2.82555772
111cilium assembly (GO:0042384)2.82306496
112ketone body metabolic process (GO:1902224)2.82187066
113energy coupled proton transport, down electrochemical gradient (GO:0015985)2.82072387
114ATP synthesis coupled proton transport (GO:0015986)2.82072387
115behavioral response to ethanol (GO:0048149)2.80348282
116cilium morphogenesis (GO:0060271)2.80311506
117lactate metabolic process (GO:0006089)2.80250494
118protein complex biogenesis (GO:0070271)2.80044070
119cellular component assembly involved in morphogenesis (GO:0010927)2.76653961
120tryptophan catabolic process (GO:0006569)2.76401890
121indole-containing compound catabolic process (GO:0042436)2.76401890
122indolalkylamine catabolic process (GO:0046218)2.76401890
123hindbrain development (GO:0030902)2.75815166
124glutamate receptor signaling pathway (GO:0007215)2.75157931
125establishment of protein localization to mitochondrial membrane (GO:0090151)2.72103411
126transmission of nerve impulse (GO:0019226)2.70900646
127neural tube formation (GO:0001841)2.70595386
128mitotic sister chromatid cohesion (GO:0007064)2.69766740
129membrane depolarization during action potential (GO:0086010)2.66891183
130tryptophan metabolic process (GO:0006568)2.65656170
131histone exchange (GO:0043486)2.63731214
132retinal ganglion cell axon guidance (GO:0031290)2.63518884
133glycerol metabolic process (GO:0006071)2.61901542
134gene silencing (GO:0016458)2.61640795
135mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60855882
136platelet dense granule organization (GO:0060155)2.58392772
137presynaptic membrane assembly (GO:0097105)2.58109854
138retina layer formation (GO:0010842)2.58010012
139regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57904299
140neuron fate determination (GO:0048664)2.57704490
141cell differentiation in spinal cord (GO:0021515)2.56990995
142renal tubule morphogenesis (GO:0061333)2.55523678
143glycolytic process (GO:0006096)2.55292681
144protein-cofactor linkage (GO:0018065)2.55156081
145action potential (GO:0001508)2.54793975
146UTP biosynthetic process (GO:0006228)2.54634725
147reflex (GO:0060004)2.53230333
148mitochondrial respiratory chain complex assembly (GO:0033108)2.53070216
149auditory behavior (GO:0031223)2.52744713
150cornea development in camera-type eye (GO:0061303)2.52290266
151mechanosensory behavior (GO:0007638)2.51613653
152sequestering of actin monomers (GO:0042989)2.50896804
153sexual reproduction (GO:0019953)2.49957229
154negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49795813
155negative regulation of translation, ncRNA-mediated (GO:0040033)2.49795813
156regulation of translation, ncRNA-mediated (GO:0045974)2.49795813
157water-soluble vitamin biosynthetic process (GO:0042364)2.49580457
158startle response (GO:0001964)2.48810990
159negative regulation of systemic arterial blood pressure (GO:0003085)2.47242400
160pyrimidine nucleobase catabolic process (GO:0006208)2.47182148
161retinal cone cell development (GO:0046549)2.46162565
162central nervous system myelination (GO:0022010)2.46088672
163axon ensheathment in central nervous system (GO:0032291)2.46088672
164photoreceptor cell development (GO:0042461)2.46006628
165peptidyl-glutamic acid modification (GO:0018200)2.45450924
166kynurenine metabolic process (GO:0070189)2.44652787
167sulfation (GO:0051923)2.43943595
168fusion of sperm to egg plasma membrane (GO:0007342)13.5458567
169cilium or flagellum-dependent cell motility (GO:0001539)13.3818088
170sperm motility (GO:0030317)11.9988628
171acrosome assembly (GO:0001675)11.2855735
172cell wall macromolecule metabolic process (GO:0044036)11.2751976
173cell wall macromolecule catabolic process (GO:0016998)11.2751976
174sperm-egg recognition (GO:0035036)11.0775196
175multicellular organism reproduction (GO:0032504)10.9471446
176axonemal dynein complex assembly (GO:0070286)10.4173634
177plasma membrane fusion (GO:0045026)10.2425754
178acrosome reaction (GO:0007340)10.1900240
179binding of sperm to zona pellucida (GO:0007339)10.0337700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.69992579
2EZH2_22144423_ChIP-Seq_EOC_Human3.71782325
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.48907897
4GBX2_23144817_ChIP-Seq_PC3_Human3.15777203
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85154072
6* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.48280998
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40547601
8FUS_26573619_Chip-Seq_HEK293_Human2.37030499
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.36233057
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34513411
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32237300
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31071887
13TAF15_26573619_Chip-Seq_HEK293_Human2.29996497
14IGF1R_20145208_ChIP-Seq_DFB_Human2.26983655
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08154576
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06797879
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04996632
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.7564093
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99466654
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99153424
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97582741
22KAP1_22055183_ChIP-Seq_ESCs_Mouse1.96084207
23P300_19829295_ChIP-Seq_ESCs_Human1.95948665
24EWS_26573619_Chip-Seq_HEK293_Human1.95798516
25VDR_22108803_ChIP-Seq_LS180_Human1.95146032
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.94878081
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94436283
28ZNF274_21170338_ChIP-Seq_K562_Hela1.92132907
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83424312
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82979726
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.77689396
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.75916157
33ER_23166858_ChIP-Seq_MCF-7_Human1.70626078
34STAT1_17558387_ChIP-Seq_HELA_Human1.67330938
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.67191387
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.64093104
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61589981
38SMAD4_21799915_ChIP-Seq_A2780_Human1.60897957
39FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59606741
40RNF2_27304074_Chip-Seq_NSC_Mouse1.59065251
41* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56928020
42GATA3_21867929_ChIP-Seq_CD8_Mouse1.56775198
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56652295
44AR_21572438_ChIP-Seq_LNCaP_Human1.55485612
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55385383
46AR_25329375_ChIP-Seq_VCAP_Human1.55326586
47* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.55104721
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54251018
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53626394
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52671538
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.50771347
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50347518
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50285898
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48925453
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.47627621
56* STAT3_23295773_ChIP-Seq_U87_Human1.47166694
57* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47048687
58WDR5_24793694_ChIP-Seq_LNCAP_Human1.46689029
59* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45207631
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45089156
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.43135724
62* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41279703
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40507725
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40371853
65BCAT_22108803_ChIP-Seq_LS180_Human1.39487495
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.39449605
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38686826
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38649722
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36500140
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35882109
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35487709
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.33252699
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32594344
74* RUNX2_22187159_ChIP-Seq_PCA_Human1.31314596
75TCF4_23295773_ChIP-Seq_U87_Human1.30252311
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30133352
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29943159
78GATA3_21867929_ChIP-Seq_TH1_Mouse1.28373035
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25938915
80* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.25608412
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.24894363
82KDM2B_26808549_Chip-Seq_REH_Human1.24082353
83TP53_22573176_ChIP-Seq_HFKS_Human1.23345793
84P53_21459846_ChIP-Seq_SAOS-2_Human1.23043807
85FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21783299
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21203218
87SOX2_19829295_ChIP-Seq_ESCs_Human1.19740792
88NANOG_19829295_ChIP-Seq_ESCs_Human1.19740792
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18764742
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.18575693
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.17435695
92CBP_20019798_ChIP-Seq_JUKART_Human1.17067017
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17067017
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16666246
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.15787958
96FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14449279
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.14449279
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.14045061
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13292036
100MYC_18940864_ChIP-ChIP_HL60_Human1.12434864
101TCF4_22108803_ChIP-Seq_LS180_Human1.11625989
102* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11578263
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09167765
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08930625
105* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08606474
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08589340
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07382107
108GF1_26923725_Chip-Seq_HPCs_Mouse1.07164224
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.07022232
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06817972
111RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06735286
112OCT4_18555785_Chip-Seq_ESCs_Mouse1.06694310
113RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06203388
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06106902
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06030821
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05538486
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04966263
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.04960406
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04724798
120SPI1_26923725_Chip-Seq_HPCs_Mouse1.04724031
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.04124685
122RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03790227
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02757770
124NOTCH1_21737748_ChIP-Seq_TLL_Human1.02547430
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02181880
126RARA_24833708_ChIP-Seq_LIVER_Mouse1.01739762
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01708721
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01243233
129REST_18959480_ChIP-ChIP_MESCs_Mouse1.00261081
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.99838631
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99654547
132SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99101952
133ERG_20517297_ChIP-Seq_VCAP_Human0.98578425
134EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98277374
135LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98187134
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.97158996
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96077033
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.96000076
139FLI1_21867929_ChIP-Seq_CD8_Mouse0.95906182
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95601495
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95058377
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94832832
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94268232
144ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93923402
145P300_18555785_Chip-Seq_ESCs_Mouse0.93518888
146* ESET_19884257_ChIP-Seq_ESCs_Mouse0.93131578
147P53_22387025_ChIP-Seq_ESCs_Mouse0.91814329
148SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91688398
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91141414
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89514355
151NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87906203
152REST_21632747_ChIP-Seq_MESCs_Mouse0.87591530
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87512412
154SOX2_21211035_ChIP-Seq_LN229_Human0.87066519
155STAT3_18555785_Chip-Seq_ESCs_Mouse0.86647106
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.86602803
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85738952
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85137405
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84640054
160NANOG_20526341_ChIP-Seq_ESCs_Human0.84455342
161TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84423510
162CMYC_18555785_Chip-Seq_ESCs_Mouse0.83985062
163ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83922897
164* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83353086
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82954177
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81818729
167POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81818729
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81432873
169PHF8_20622854_ChIP-Seq_HELA_Human0.81246778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.88143544
2MP0001929_abnormal_gametogenesis5.53625771
3MP0008877_abnormal_DNA_methylation5.21395057
4MP0002210_abnormal_sex_determination3.85014147
5MP0001145_abnormal_male_reproductive3.24480876
6MP0002653_abnormal_ependyma_morphology3.24222547
7MP0002161_abnormal_fertility/fecundity3.21416602
8MP0003136_yellow_coat_color3.17972737
9MP0000653_abnormal_sex_gland2.82205969
10MP0001968_abnormal_touch/_nociception2.41888931
11MP0005670_abnormal_white_adipose2.23762981
12MP0003283_abnormal_digestive_organ2.18384345
13MP0009745_abnormal_behavioral_response2.13573362
14MP0004142_abnormal_muscle_tone2.09425845
15MP0002160_abnormal_reproductive_system2.02928073
16MP0004742_abnormal_vestibular_system2.01358555
17MP0008057_abnormal_DNA_replication2.00369725
18MP0005410_abnormal_fertilization14.9742711
19MP0002837_dystrophic_cardiac_calcinosis1.96827169
20MP0005623_abnormal_meninges_morphology1.95416071
21MP0002938_white_spotting1.93642481
22MP0004885_abnormal_endolymph1.93614678
23MP0003880_abnormal_central_pattern1.91323916
24MP0002736_abnormal_nociception_after1.91171422
25MP0003195_calcinosis1.90208546
26MP0002272_abnormal_nervous_system1.88828737
27MP0001485_abnormal_pinna_reflex1.88396430
28MP0001486_abnormal_startle_reflex1.86894928
29MP0006072_abnormal_retinal_apoptosis1.83652485
30MP0001529_abnormal_vocalization1.81961012
31MP0006292_abnormal_olfactory_placode1.78986316
32MP0002638_abnormal_pupillary_reflex1.72504676
33MP0003787_abnormal_imprinting1.69613999
34MP0002572_abnormal_emotion/affect_behav1.67373960
35MP0000631_abnormal_neuroendocrine_gland1.67274545
36MP0000372_irregular_coat_pigmentation1.66255894
37MP0008058_abnormal_DNA_repair1.61539224
38MP0003646_muscle_fatigue1.57859728
39MP0005646_abnormal_pituitary_gland1.57205068
40MP0002064_seizures1.56294961
41MP0005171_absent_coat_pigmentation1.56216989
42MP0002067_abnormal_sensory_capabilities1.55679069
43MP0002557_abnormal_social/conspecific_i1.51575351
44MP0010094_abnormal_chromosome_stability1.51423245
45MP0002735_abnormal_chemical_nociception1.49943026
46MP0009379_abnormal_foot_pigmentation1.49116637
47MP0002282_abnormal_trachea_morphology1.49103373
48MP0005423_abnormal_somatic_nervous1.48609043
49MP0003635_abnormal_synaptic_transmissio1.47814539
50MP0005386_behavior/neurological_phenoty1.46825296
51MP0004924_abnormal_behavior1.46825296
52MP0001986_abnormal_taste_sensitivity1.46450464
53MP0001905_abnormal_dopamine_level1.46174894
54MP0001501_abnormal_sleep_pattern1.39270407
55MP0000778_abnormal_nervous_system1.39162525
56MP0006276_abnormal_autonomic_nervous1.37289200
57MP0003122_maternal_imprinting1.35438024
58MP0002063_abnormal_learning/memory/cond1.34930096
59MP0002733_abnormal_thermal_nociception1.29277732
60MP0001970_abnormal_pain_threshold1.28413991
61MP0003121_genomic_imprinting1.28301533
62MP0000026_abnormal_inner_ear1.26549816
63MP0002734_abnormal_mechanical_nocicepti1.24934109
64MP0008872_abnormal_physiological_respon1.22571851
65MP0003111_abnormal_nucleus_morphology1.21284332
66MP0005645_abnormal_hypothalamus_physiol1.21029936
67MP0005195_abnormal_posterior_eye1.20661974
68MP0003786_premature_aging1.17896088
69MP0003693_abnormal_embryo_hatching1.14673081
70MP0005389_reproductive_system_phenotype1.13877300
71MP0002277_abnormal_respiratory_mucosa1.11756255
72MP0001440_abnormal_grooming_behavior1.10937115
73MP0005084_abnormal_gallbladder_morpholo1.09536598
74MP0004233_abnormal_muscle_weight1.09030412
75MP0001984_abnormal_olfaction1.08750235
76MP0002752_abnormal_somatic_nervous1.06954158
77MP0003119_abnormal_digestive_system1.06845288
78MP0005647_abnormal_sex_gland1.06529247
79MP0002751_abnormal_autonomic_nervous1.05804875
80MP0001963_abnormal_hearing_physiology1.04864875
81MP0000955_abnormal_spinal_cord1.04594225
82MP0000566_synostosis1.03161090
83MP0004147_increased_porphyrin_level1.02445686
84MP0002184_abnormal_innervation0.99385153
85MP0009046_muscle_twitch0.98608258
86MP0002876_abnormal_thyroid_physiology0.97764587
87MP0008007_abnormal_cellular_replicative0.96994676
88MP0005174_abnormal_tail_pigmentation0.96906805
89MP0002163_abnormal_gland_morphology0.96758842
90MP0000049_abnormal_middle_ear0.95679302
91MP0000383_abnormal_hair_follicle0.94356465
92MP0001765_abnormal_ion_homeostasis0.92973848
93MP0002882_abnormal_neuron_morphology0.92919122
94MP0003937_abnormal_limbs/digits/tail_de0.91153617
95MP0010386_abnormal_urinary_bladder0.88707923
96MP0008995_early_reproductive_senescence0.87595277
97MP0005377_hearing/vestibular/ear_phenot0.87507291
98MP0003878_abnormal_ear_physiology0.87507291
99MP0005379_endocrine/exocrine_gland_phen0.87023456
100MP0005187_abnormal_penis_morphology0.85921822
101MP0002229_neurodegeneration0.84540755
102MP0003011_delayed_dark_adaptation0.82675157
103MP0002095_abnormal_skin_pigmentation0.81635126
104MP0004215_abnormal_myocardial_fiber0.80911563
105MP0000358_abnormal_cell_content/0.74968947
106MP0001730_embryonic_growth_arrest0.71939102
107MP0003077_abnormal_cell_cycle0.71424000
108MP0002234_abnormal_pharynx_morphology0.63169689
109MP0004019_abnormal_vitamin_homeostasis0.61435228
110MP0001661_extended_life_span0.60051877
111MP0006036_abnormal_mitochondrial_physio0.59628029
112MP0003699_abnormal_female_reproductive0.58678132
113MP0001764_abnormal_homeostasis0.58540755
114MP0005636_abnormal_mineral_homeostasis0.58434033
115MP0001119_abnormal_female_reproductive0.56248420
116MP0002139_abnormal_hepatobiliary_system0.55319013
117MP0005397_hematopoietic_system_phenotyp0.54692290
118MP0001545_abnormal_hematopoietic_system0.54692290
119MP0004957_abnormal_blastocyst_morpholog0.53128335
120MP0003950_abnormal_plasma_membrane0.52287041
121MP0002928_abnormal_bile_duct0.49537703
122MP0010307_abnormal_tumor_latency0.49479350
123MP0004036_abnormal_muscle_relaxation0.48817419
124MP0004134_abnormal_chest_morphology0.47895421
125MP0008932_abnormal_embryonic_tissue0.47071777
126MP0003115_abnormal_respiratory_system0.46962527
127MP0002269_muscular_atrophy0.43975134
128MP0002102_abnormal_ear_morphology0.43526610
129MP0004808_abnormal_hematopoietic_stem0.41457236
130MP0006035_abnormal_mitochondrial_morpho0.41340534
131MP0000313_abnormal_cell_death0.40894301
132MP0001672_abnormal_embryogenesis/_devel0.39914382
133MP0005380_embryogenesis_phenotype0.39914382
134MP0001293_anophthalmia0.39211231
135MP0001697_abnormal_embryo_size0.39090704
136MP0005666_abnormal_adipose_tissue0.37834537
137MP0002084_abnormal_developmental_patter0.36112254
138MP0003315_abnormal_perineum_morphology0.35433883
139MP0003718_maternal_effect0.35101962
140MP0004084_abnormal_cardiac_muscle0.34126499
141MP0001727_abnormal_embryo_implantation0.34054596
142MP0001324_abnormal_eye_pigmentation0.33729980
143MP0003984_embryonic_growth_retardation0.33618807
144MP0004133_heterotaxia0.32909299
145MP0003329_amyloid_beta_deposits0.32882893
146MP0000427_abnormal_hair_cycle0.32869992
147MP0003806_abnormal_nucleotide_metabolis0.31956470
148MP0001919_abnormal_reproductive_system0.31787811
149MP0002088_abnormal_embryonic_growth/wei0.31450137
150MP0005365_abnormal_bile_salt0.31076585
151MP0002080_prenatal_lethality0.30149897
152MP0003936_abnormal_reproductive_system0.28167675
153MP0002971_abnormal_brown_adipose0.27294681
154MP0005391_vision/eye_phenotype0.24875548
155MP0004197_abnormal_fetal_growth/weight/0.23596876
156MP0002085_abnormal_embryonic_tissue0.23101828
157MP0009115_abnormal_fat_cell0.22504726
158MP0004145_abnormal_muscle_electrophysio0.21749854
159MP0003861_abnormal_nervous_system0.21603945
160MP0005319_abnormal_enzyme/_coenzyme0.20781357
161MP0005253_abnormal_eye_physiology0.20566226
162MP0000647_abnormal_sebaceous_gland0.20199793
163MP0000432_abnormal_head_morphology0.19842292
164MP0005551_abnormal_eye_electrophysiolog0.19529974
165MP0000569_abnormal_digit_pigmentation0.19464020
166MP0005395_other_phenotype0.18637512
167MP0008875_abnormal_xenobiotic_pharmacok0.18392394
168MP0000015_abnormal_ear_pigmentation0.18254131
169MP0002092_abnormal_eye_morphology0.17839176
170MP0003879_abnormal_hair_cell0.17697691
171MP0002132_abnormal_respiratory_system0.17461678
172MP0004043_abnormal_pH_regulation0.17353808
173MP0003890_abnormal_embryonic-extraembry0.15451086

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.42833310
2Abnormal respiratory motile cilium morphology (HP:0005938)8.94223104
3Abnormal respiratory epithelium morphology (HP:0012253)8.94223104
4Rhinitis (HP:0012384)8.07394234
5Abnormal ciliary motility (HP:0012262)7.58416814
6Chronic bronchitis (HP:0004469)7.31313801
7Nasal polyposis (HP:0100582)6.34260974
8Infertility (HP:0000789)6.23554735
9Abnormality of the nasal mucosa (HP:0000433)5.14803085
10Bronchiectasis (HP:0002110)4.61409655
11Bronchitis (HP:0012387)4.50167615
12Nephronophthisis (HP:0000090)4.34538485
13Pancreatic cysts (HP:0001737)4.15528238
14Male infertility (HP:0003251)3.65435836
15Recurrent sinusitis (HP:0011108)3.44002622
16Progressive cerebellar ataxia (HP:0002073)3.38647671
17Abnormal spermatogenesis (HP:0008669)3.36461008
18Recurrent otitis media (HP:0000403)3.35238088
19Abnormality of the renal medulla (HP:0100957)3.30288236
20Hyperventilation (HP:0002883)3.18632212
21Congenital stationary night blindness (HP:0007642)3.18544833
22Congenital, generalized hypertrichosis (HP:0004540)3.08627313
23Large for gestational age (HP:0001520)2.99757148
24Abnormality of the lower motor neuron (HP:0002366)2.92898196
25Type II lissencephaly (HP:0007260)2.89502468
26Tubulointerstitial nephritis (HP:0001970)2.86672843
27Impulsivity (HP:0100710)2.83015212
28Chronic hepatic failure (HP:0100626)2.78881443
29Medial flaring of the eyebrow (HP:0010747)2.74765080
30Focal motor seizures (HP:0011153)2.73587379
31Gonadotropin excess (HP:0000837)2.72950897
32Molar tooth sign on MRI (HP:0002419)2.66377643
33Abnormality of midbrain morphology (HP:0002418)2.66377643
34Azoospermia (HP:0000027)2.66283129
35Recurrent bronchitis (HP:0002837)2.62736825
36Fibular hypoplasia (HP:0003038)2.60338186
37Attenuation of retinal blood vessels (HP:0007843)2.55241281
38Tubular atrophy (HP:0000092)2.51649704
39Protruding tongue (HP:0010808)2.51552964
40Sclerocornea (HP:0000647)2.51271400
41Hypoplasia of the capital femoral epiphysis (HP:0003090)2.43972154
42Abolished electroretinogram (ERG) (HP:0000550)2.40996195
43Vaginal atresia (HP:0000148)2.40329638
44Limb dystonia (HP:0002451)2.38080010
45Febrile seizures (HP:0002373)2.38066516
46Genetic anticipation (HP:0003743)2.35599536
47Hemiparesis (HP:0001269)2.34190811
48Optic nerve hypoplasia (HP:0000609)2.34186294
49Abnormal rod and cone electroretinograms (HP:0008323)2.33324805
50Tubulointerstitial abnormality (HP:0001969)2.33163029
51Amyotrophic lateral sclerosis (HP:0007354)2.31308661
52Abnormality of alanine metabolism (HP:0010916)2.30455227
53Hyperalaninemia (HP:0003348)2.30455227
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30455227
55Septo-optic dysplasia (HP:0100842)2.29145748
56Furrowed tongue (HP:0000221)2.29113699
57Inability to walk (HP:0002540)2.28130340
58Abnormality of macular pigmentation (HP:0008002)2.28098840
59Oligodactyly (hands) (HP:0001180)2.27937520
60Hypothermia (HP:0002045)2.27051802
61Acute necrotizing encephalopathy (HP:0006965)2.26609377
62Anencephaly (HP:0002323)2.21765039
63Concave nail (HP:0001598)2.21195511
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.20585665
65Absent epiphyses (HP:0010577)2.15732687
66Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15732687
67Prominent supraorbital ridges (HP:0000336)2.12481503
68Renal cortical cysts (HP:0000803)2.11283444
69Optic disc pallor (HP:0000543)2.08733291
70Postaxial foot polydactyly (HP:0001830)2.08726018
713-Methylglutaconic aciduria (HP:0003535)2.08455376
72Gaze-evoked nystagmus (HP:0000640)2.06505745
73Abnormality of the anterior horn cell (HP:0006802)2.06127867
74Degeneration of anterior horn cells (HP:0002398)2.06127867
75Abnormality of the labia minora (HP:0012880)2.05461613
76Broad-based gait (HP:0002136)2.04931016
77Birth length less than 3rd percentile (HP:0003561)2.03867047
78Male pseudohermaphroditism (HP:0000037)2.03550291
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.02906695
80Increased corneal curvature (HP:0100692)2.01506888
81Keratoconus (HP:0000563)2.01506888
82Acute encephalopathy (HP:0006846)2.01292747
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6083589
84Dynein arm defect of respiratory motile cilia (HP:0012255)12.4402414
85Absent/shortened dynein arms (HP:0200106)12.4402414
86Progressive macrocephaly (HP:0004481)1.96164217
87Focal seizures (HP:0007359)1.94462330
88Short ribs (HP:0000773)1.93184871
89Dialeptic seizures (HP:0011146)1.92729979
90Bony spicule pigmentary retinopathy (HP:0007737)1.89842374
91Mitochondrial inheritance (HP:0001427)1.88648269
92Abnormality of the pons (HP:0007361)1.88399046
93Progressive inability to walk (HP:0002505)1.87766526
94Absent frontal sinuses (HP:0002688)1.86611038
95Facial cleft (HP:0002006)1.86322965
96Stage 5 chronic kidney disease (HP:0003774)1.85694676
97Lissencephaly (HP:0001339)1.85456520
98Impaired proprioception (HP:0010831)1.85217917
99Severe muscular hypotonia (HP:0006829)1.82823520
100Methylmalonic acidemia (HP:0002912)1.82150036
101Abnormality of the renal cortex (HP:0011035)1.82013198
102Patellar aplasia (HP:0006443)1.81626864
103Congenital hepatic fibrosis (HP:0002612)1.80170542
104Spastic tetraparesis (HP:0001285)1.80095628
105Microglossia (HP:0000171)1.77859004
106Tubulointerstitial fibrosis (HP:0005576)1.77264809
107Pendular nystagmus (HP:0012043)1.77000651
108Shawl scrotum (HP:0000049)1.76799107
109Rib fusion (HP:0000902)1.75863632
110Specific learning disability (HP:0001328)1.75684337
111Hypoplasia of the pons (HP:0012110)1.74482054
112Chronic sinusitis (HP:0011109)1.74128453
113Renal dysplasia (HP:0000110)1.74051442
114Oculomotor apraxia (HP:0000657)1.73896452
115Abnormal mitochondria in muscle tissue (HP:0008316)1.73697406
116Occipital encephalocele (HP:0002085)1.73432418
117Aplasia/Hypoplasia of the fibula (HP:0006492)1.72583263
118Congenital primary aphakia (HP:0007707)1.68075940
119Upper motor neuron abnormality (HP:0002127)1.67230489
120Gait imbalance (HP:0002141)1.65321163
121Abnormal drinking behavior (HP:0030082)1.61762337
122Polydipsia (HP:0001959)1.61762337
123Postaxial hand polydactyly (HP:0001162)1.61554651
124Abnormality of permanent molar morphology (HP:0011071)1.60561503
125Abnormality of the dental root (HP:0006486)1.60561503
126Taurodontia (HP:0000679)1.60561503
127Supernumerary spleens (HP:0009799)1.60182967
128Median cleft lip (HP:0000161)1.55415001
129Pancreatic fibrosis (HP:0100732)1.55285605
130Abnormality of dentin (HP:0010299)1.54627055
131J-shaped sella turcica (HP:0002680)1.49956147
132Abnormality of renal excretion (HP:0011036)1.48970388
133Abnormality of molar morphology (HP:0011070)1.48565707
134Abnormality of molar (HP:0011077)1.48565707
135Short femoral neck (HP:0100864)1.48541895
136Abnormal gallbladder physiology (HP:0012438)1.45384603
137Cholecystitis (HP:0001082)1.45384603
138Abnormal biliary tract physiology (HP:0012439)1.44823574
139Bile duct proliferation (HP:0001408)1.44823574
140Abnormality of the dental pulp (HP:0006479)1.43636172
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.43144351
142Bell-shaped thorax (HP:0001591)1.42537182
143Nephrogenic diabetes insipidus (HP:0009806)1.42083910
144Short thorax (HP:0010306)1.41471425
145Heterotopia (HP:0002282)1.39866272
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.39463572
147Breast carcinoma (HP:0003002)1.38889438
148Poor coordination (HP:0002370)1.36968338
14911 pairs of ribs (HP:0000878)1.36470121
150Dyschromatopsia (HP:0007641)1.36166101
151Cystic liver disease (HP:0006706)1.35680390
152Aplasia/Hypoplasia of the lens (HP:0008063)1.35210258
153Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.26528315
154Nephropathy (HP:0000112)1.26300884
155Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.25722932
156Selective tooth agenesis (HP:0001592)1.23553102
157Abnormality of ocular smooth pursuit (HP:0000617)1.23286012
158Irregular epiphyses (HP:0010582)1.21580097
159Short nail (HP:0001799)1.21115330
160Decreased central vision (HP:0007663)1.21100877
161Tongue fasciculations (HP:0001308)1.21028298
162Cerebellar dysplasia (HP:0007033)1.19456612
163True hermaphroditism (HP:0010459)1.19293578
164Genital tract atresia (HP:0001827)1.17190346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.90693637
2PDK48.90693637
3PDK25.89210135
4TESK14.58832314
5FRK3.92781615
6PRKD33.71099177
7ICK3.15659071
8ADRBK22.90578202
9CASK2.83978805
10INSRR2.75278132
11WNK42.41306517
12MAP3K42.35000472
13STK392.28588244
14PNCK2.27324004
15MAPK132.27278407
16MARK12.18780604
17PTK2B2.12660676
18ZAK2.11017874
19NEK22.06709673
20GRK12.01663548
21ACVR1B1.93445293
22MKNK21.92580075
23TNIK1.81459376
24OXSR11.46617728
25DAPK21.42084332
26MAP4K21.39843526
27WEE11.38935033
28MAP2K71.37086843
29STK381.35946138
30TAOK31.33872882
31NUAK11.29022027
32DYRK21.24200172
33NTRK31.20765786
34MKNK11.20177387
35VRK11.18335470
36TLK11.16785740
37PLK41.13219044
38ADRBK11.07672250
39CDK191.04675881
40STK31.00483999
41PRKCE0.99921267
42PLK20.99165754
43TGFBR10.98617012
44CSNK1G20.94429739
45MAP2K40.93437342
46PAK30.92605757
47DYRK1B0.92383694
48TTK0.92267386
49CCNB10.91361393
50WNK10.90022207
51PASK0.88487343
52PDK10.86035678
53DYRK30.85597263
54MAPK150.83884725
55NME10.81852050
56CDC70.81358746
57IRAK10.76726916
58PINK10.76689206
59STK38L0.76172754
60CAMK2A0.71442704
61CHEK20.71024369
62BUB10.69645069
63CSNK1G30.67070381
64CSNK1G10.66735904
65TSSK60.65507263
66BRSK20.63264628
67PKN10.63251049
68TAF10.63087676
69TYRO30.62809459
70PIK3CA0.61992123
71PHKG20.60212490
72PHKG10.60212490
73RPS6KA50.59854052
74EIF2AK10.59507827
75CHEK10.58814725
76TRIM280.58787612
77TESK20.58397614
78ERBB30.58153123
79SGK20.57556978
80CDK120.55582824
81OBSCN0.53444572
82ATR0.53211944
83SGK10.52895884
84PRKACA0.51979459
85DYRK1A0.51857517
86CAMK10.49857900
87PLK10.49225650
88TIE10.48740682
89MAP3K120.48315681
90CHUK0.48020751
91TXK0.47447271
92MST1R0.46667629
93EPHB20.45941672
94BCR0.45753627
95EPHA20.44197335
96ERBB20.44180914
97CAMK2B0.44124102
98SGK2230.41459947
99SGK4940.41459947
100BRAF0.40456054
101CAMKK20.39565430
102PAK10.37845816
103FGFR20.36481852
104ATM0.35756955
105MAP2K60.35583910
106LMTK20.35560297
107BCKDK0.35164062
108NEK60.34337682
109PDPK10.33977438
110RPS6KA60.32452531
111SRPK10.32061026
112CSNK1A10.31369532
113IRAK20.31262680
114UHMK10.31000570
115PRKCA0.30871274
116MINK10.30758271
117CAMK2D0.29932927
118BRSK10.26191308
119AKT30.24284396
120MTOR0.23481818
121EEF2K0.23241999
122AURKA0.20582947
123PRKAA10.20405069
124MUSK0.19777160
125PRKCG0.19334358
126RPS6KB10.17489103
127CSNK2A10.16456993
128MARK30.15040778
129WNK30.14910150
130CAMK1G0.14888987
131CAMKK10.14629507
132EIF2AK30.14560700
133STK100.14539463
134BMPR1B0.12923603
135AURKB0.11422390
136MAP3K30.11171906
137CDK20.11029760
138MET0.10982158
139PAK20.09648876
140STK160.09517321
141CDK70.08960256
142CDK10.08688550
143CSNK2A20.08413133
144CDK40.07303007
145MAPKAPK50.05578797
146PIM10.04511463
147PRKG20.04079884
148CDK30.03967677
149PAK40.03621039
150ZAP700.03617683
151PRKCZ0.03454391
152GSK3B0.02557394
153PLK30.01720128
154PRKACG0.01404429
155CSNK1D0.00361605
156CDK18-0.0372585
157STK11-0.0341975
158CDK6-0.0334289
159RPS6KA1-0.0322641
160CDK11A-0.0291926
161RIPK4-0.0242650
162NTRK2-0.0213190
163CDK15-0.0135307
164PIM2-0.0122789
165MARK2-0.0122743
166PRKCQ-0.0109802
167PRKG1-0.0074754
168PRKDC-0.0043559
169MAPK8-0.0001142

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.29420652
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.86762451
3Pyruvate metabolism_Homo sapiens_hsa006203.77840535
4Basal transcription factors_Homo sapiens_hsa030223.21112160
5Nicotine addiction_Homo sapiens_hsa050333.06694459
6Propanoate metabolism_Homo sapiens_hsa006403.04369463
7Pentose phosphate pathway_Homo sapiens_hsa000302.96497972
8Fatty acid biosynthesis_Homo sapiens_hsa000612.89715820
9Oxidative phosphorylation_Homo sapiens_hsa001902.75817287
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74713231
11Protein export_Homo sapiens_hsa030602.71652342
12Selenocompound metabolism_Homo sapiens_hsa004502.70473066
13Fanconi anemia pathway_Homo sapiens_hsa034602.63537048
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.52530891
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.48538879
16Linoleic acid metabolism_Homo sapiens_hsa005912.44822256
17Butanoate metabolism_Homo sapiens_hsa006502.44589400
18Phototransduction_Homo sapiens_hsa047442.37977858
19Glucagon signaling pathway_Homo sapiens_hsa049222.30035606
20Parkinsons disease_Homo sapiens_hsa050122.28989248
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02209399
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01598756
23Nitrogen metabolism_Homo sapiens_hsa009101.98655611
24RNA transport_Homo sapiens_hsa030131.98520663
25Glycerolipid metabolism_Homo sapiens_hsa005611.95904984
26Oocyte meiosis_Homo sapiens_hsa041141.91161074
27Taste transduction_Homo sapiens_hsa047421.88081695
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86319029
29Huntingtons disease_Homo sapiens_hsa050161.85806682
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83186391
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80042056
32Dorso-ventral axis formation_Homo sapiens_hsa043201.76908809
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75438979
34Fructose and mannose metabolism_Homo sapiens_hsa000511.73883383
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.70823661
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65031910
37Carbon metabolism_Homo sapiens_hsa012001.62774391
38Glutamatergic synapse_Homo sapiens_hsa047241.61777565
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61311736
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.60428966
41PPAR signaling pathway_Homo sapiens_hsa033201.55951679
42Alzheimers disease_Homo sapiens_hsa050101.49738232
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48623339
44Morphine addiction_Homo sapiens_hsa050321.46078058
45Olfactory transduction_Homo sapiens_hsa047401.45955217
46Proteasome_Homo sapiens_hsa030501.45692554
47Ribosome_Homo sapiens_hsa030101.45295141
48Caffeine metabolism_Homo sapiens_hsa002321.45227012
49Tryptophan metabolism_Homo sapiens_hsa003801.43917651
50mRNA surveillance pathway_Homo sapiens_hsa030151.42562142
51Purine metabolism_Homo sapiens_hsa002301.42018080
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40154189
53Circadian entrainment_Homo sapiens_hsa047131.34770283
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.32375997
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31447799
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.31346911
57GABAergic synapse_Homo sapiens_hsa047271.26354795
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25355235
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25135185
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24806990
61Fat digestion and absorption_Homo sapiens_hsa049751.21063705
62Serotonergic synapse_Homo sapiens_hsa047261.19670724
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18900915
64Pyrimidine metabolism_Homo sapiens_hsa002401.18347737
65Cocaine addiction_Homo sapiens_hsa050301.16614012
66Biosynthesis of amino acids_Homo sapiens_hsa012301.14008083
67Homologous recombination_Homo sapiens_hsa034401.13802004
68Glutathione metabolism_Homo sapiens_hsa004801.12625178
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12189623
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10775777
71Antigen processing and presentation_Homo sapiens_hsa046121.10222870
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03528339
73Ether lipid metabolism_Homo sapiens_hsa005651.02283304
74Insulin secretion_Homo sapiens_hsa049110.99883213
75Long-term depression_Homo sapiens_hsa047300.99476815
76Amphetamine addiction_Homo sapiens_hsa050310.97291826
77Fatty acid degradation_Homo sapiens_hsa000710.96092530
78Cardiac muscle contraction_Homo sapiens_hsa042600.95670498
79Dopaminergic synapse_Homo sapiens_hsa047280.93867500
80Ovarian steroidogenesis_Homo sapiens_hsa049130.92506830
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92299943
82Fatty acid metabolism_Homo sapiens_hsa012120.90749607
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90664803
84Mineral absorption_Homo sapiens_hsa049780.88743100
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87897051
86Peroxisome_Homo sapiens_hsa041460.86008407
87DNA replication_Homo sapiens_hsa030300.84128611
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83925060
89Arachidonic acid metabolism_Homo sapiens_hsa005900.81864334
90Basal cell carcinoma_Homo sapiens_hsa052170.78964332
91Renin-angiotensin system_Homo sapiens_hsa046140.75091965
92Cholinergic synapse_Homo sapiens_hsa047250.74367189
93Steroid biosynthesis_Homo sapiens_hsa001000.73434316
94Cell cycle_Homo sapiens_hsa041100.73067993
95Spliceosome_Homo sapiens_hsa030400.70561966
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69127285
97Chemical carcinogenesis_Homo sapiens_hsa052040.68479349
98beta-Alanine metabolism_Homo sapiens_hsa004100.67309840
99ABC transporters_Homo sapiens_hsa020100.65839702
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65589846
101Metabolic pathways_Homo sapiens_hsa011000.62921736
102Systemic lupus erythematosus_Homo sapiens_hsa053220.62778150
103RNA degradation_Homo sapiens_hsa030180.60079510
104Salivary secretion_Homo sapiens_hsa049700.59070640
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58536992
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57776860
107N-Glycan biosynthesis_Homo sapiens_hsa005100.55371947
108Regulation of autophagy_Homo sapiens_hsa041400.55298859
109Renin secretion_Homo sapiens_hsa049240.54030378
110Histidine metabolism_Homo sapiens_hsa003400.53720386
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53524974
112Oxytocin signaling pathway_Homo sapiens_hsa049210.50760813
113Collecting duct acid secretion_Homo sapiens_hsa049660.49825194
114Hedgehog signaling pathway_Homo sapiens_hsa043400.48071322
115Gastric acid secretion_Homo sapiens_hsa049710.47570863
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.46339499
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46010763
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45347761
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44679817
120Base excision repair_Homo sapiens_hsa034100.43400104
121Axon guidance_Homo sapiens_hsa043600.43361529
122Nucleotide excision repair_Homo sapiens_hsa034200.41687241
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.40480866
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39945865
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.39922169
126cAMP signaling pathway_Homo sapiens_hsa040240.39761339
127Sphingolipid metabolism_Homo sapiens_hsa006000.39031012
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39013258
129Asthma_Homo sapiens_hsa053100.38927535
130Sulfur relay system_Homo sapiens_hsa041220.38641931
131Legionellosis_Homo sapiens_hsa051340.38612003
132One carbon pool by folate_Homo sapiens_hsa006700.38253986
133Epstein-Barr virus infection_Homo sapiens_hsa051690.38085685
134Circadian rhythm_Homo sapiens_hsa047100.37536608
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36952867
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36662557
137AMPK signaling pathway_Homo sapiens_hsa041520.35390185
138Protein digestion and absorption_Homo sapiens_hsa049740.31910432
139Retinol metabolism_Homo sapiens_hsa008300.30104992
140Endocytosis_Homo sapiens_hsa041440.29347373
141Synaptic vesicle cycle_Homo sapiens_hsa047210.29128639
142Tyrosine metabolism_Homo sapiens_hsa003500.29057786
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29053249
144Long-term potentiation_Homo sapiens_hsa047200.27737025
145Inositol phosphate metabolism_Homo sapiens_hsa005620.26404821
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.26366876
147Estrogen signaling pathway_Homo sapiens_hsa049150.24710050
148Mismatch repair_Homo sapiens_hsa034300.24153045
149p53 signaling pathway_Homo sapiens_hsa041150.23581586
150Viral carcinogenesis_Homo sapiens_hsa052030.23525219
151Pancreatic secretion_Homo sapiens_hsa049720.21808176
152Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21058774
153Bile secretion_Homo sapiens_hsa049760.20191858
154cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20129611
155Thyroid hormone synthesis_Homo sapiens_hsa049180.18723633
156Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16895971
157RNA polymerase_Homo sapiens_hsa030200.16435298
158Sulfur metabolism_Homo sapiens_hsa009200.15443538
159Vitamin digestion and absorption_Homo sapiens_hsa049770.14829961
160Calcium signaling pathway_Homo sapiens_hsa040200.11147058
161Steroid hormone biosynthesis_Homo sapiens_hsa001400.10829042

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